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Conserved domains on  [gi|1230885081|gb|AST60328|]
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16S rRNA (cytosine(1402)-N(4))-methyltransferase [Staphylococcus lugdunensis]

Protein Classification

class I SAM-dependent methyltransferase( domain architecture ID 13392866)

class I SAM-dependent methyltransferase catalyzes the methylation of one or more specific substrates using S-adenosyl-L-methionine (SAM or AdoMet) as the methyl donor

CATH:  3.40.50.150
EC:  2.1.1.-
Gene Ontology:  GO:1904047|GO:0008168|GO:0032259|GO:0008757
PubMed:  12504684|12826405
SCOP:  3000118

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
rRNA_methylase pfam06962
Putative rRNA methylase; This family contains a number of putative rRNA methylases. Note that ...
 47-184 6.07e-69

Putative rRNA methylase; This family contains a number of putative rRNA methylases. Note that many family members are hypothetical proteins.


:

Pssm-ID: 429214  Cd Length: 137  Bit Score: 206.10  E-value: 6.07e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1230885081  47 VYGFDIQQQAIDNTAKKIKSF---KNVSLIHDSHEYISDHLisahKNKITAAIFNLGYLPKGDKSIVTQPESTIRAIDAI 123
Cdd:pfam06962   1 VYAFDIQEEALENTRERLEEEgleERVELILDGHENLDEYV----PGPVDAAMFNLGYLPGGDKSITTKPETTLKALEAA 76

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1230885081 124 FEQLTIEGIIVVVIYHGHFQGKLERDALLDYFSNIDQTKAQVLQYQFINQRNDAPFICAIE 184
Cdd:pfam06962  77 LELLKPGGIISLVVYPGHPGGKEEKEAVLEYLSSLDQKKYNVLKYEFLNQPNNPPFLVLIE 137
Gcd14 super family cl34476
tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 ...
 1-74 3.28e-07

tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 N-methylase Trm61 is part of the Pathway/BioSystem: tRNA modification


The actual alignment was detected with superfamily member COG2519:

Pssm-ID: 442009 [Multi-domain]  Cd Length: 249  Bit Score: 48.62  E-value: 3.28e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1230885081   1 MKLER----ILPFAKSLITSH--IQSDSIVIDATCGNGFDTLFLAQHV-PKGHVYGFDIQQQAIDNTAKKIKSF---KNV 70
Cdd:COG2519    66 LSMKRgtqiIYPKDAGYIIARldIFPGARVLEAGTGSGALTLALARAVgPEGKVYSYERREDFAEIARKNLERFglpDNV 145


                  ....
gi 1230885081  71 SLIH 74
Cdd:COG2519   146 ELKL 149
 
Name Accession Description Interval E-value
rRNA_methylase pfam06962
Putative rRNA methylase; This family contains a number of putative rRNA methylases. Note that ...
 47-184 6.07e-69

Putative rRNA methylase; This family contains a number of putative rRNA methylases. Note that many family members are hypothetical proteins.


Pssm-ID: 429214  Cd Length: 137  Bit Score: 206.10  E-value: 6.07e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1230885081  47 VYGFDIQQQAIDNTAKKIKSF---KNVSLIHDSHEYISDHLisahKNKITAAIFNLGYLPKGDKSIVTQPESTIRAIDAI 123
Cdd:pfam06962   1 VYAFDIQEEALENTRERLEEEgleERVELILDGHENLDEYV----PGPVDAAMFNLGYLPGGDKSITTKPETTLKALEAA 76

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1230885081 124 FEQLTIEGIIVVVIYHGHFQGKLERDALLDYFSNIDQTKAQVLQYQFINQRNDAPFICAIE 184
Cdd:pfam06962  77 LELLKPGGIISLVVYPGHPGGKEEKEAVLEYLSSLDQKKYNVLKYEFLNQPNNPPFLVLIE 137
RmsH COG0275
16S rRNA C1402 N4-methylase RsmH [Translation, ribosomal structure and biogenesis]; 16S rRNA ...
 18-100 2.57e-09

16S rRNA C1402 N4-methylase RsmH [Translation, ribosomal structure and biogenesis]; 16S rRNA C1402 N4-methylase RsmH is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 440044  Cd Length: 312  Bit Score: 55.07  E-value: 2.57e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1230885081  18 IQSDSIVIDATCGNGFDT-LFLAQHVPKGHVYGFDIQQQAIDNTAKKIKSFK-NVSLIHDSHEYISDHLISAHKNKITAA 95
Cdd:COG0275    21 PKPGGVYVDGTLGGGGHSrAILERLGPGGRLIGIDRDPDAIAAAKERLAEFGdRFTLVHGNFSELDEVLAELGIEKVDGI 100


                  ....*
gi 1230885081  96 IFNLG 100
Cdd:COG0275   101 LLDLG 105
Gcd14 COG2519
tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 ...
 1-74 3.28e-07

tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 N-methylase Trm61 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 442009 [Multi-domain]  Cd Length: 249  Bit Score: 48.62  E-value: 3.28e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1230885081   1 MKLER----ILPFAKSLITSH--IQSDSIVIDATCGNGFDTLFLAQHV-PKGHVYGFDIQQQAIDNTAKKIKSF---KNV 70
Cdd:COG2519    66 LSMKRgtqiIYPKDAGYIIARldIFPGARVLEAGTGSGALTLALARAVgPEGKVYSYERREDFAEIARKNLERFglpDNV 145


                  ....
gi 1230885081  71 SLIH 74
Cdd:COG2519   146 ELKL 149
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 18-74 1.44e-05

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 43.17  E-value: 1.44e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1230885081  18 IQSDSIVIDATCGNGFDTLFLAQHV-PKGHVYGFDIQQQAIDNtAKKIKS---FKNVSLIH 74
Cdd:pfam13847   1 IDKGMRVLDLGCGTGHLSFELAEELgPNAEVVGIDISEEAIEK-ARENAQklgFDNVEFEQ 60
fkbM_fam TIGR01444
methyltransferase, FkbM family; Members of this family are characterized by two well-conserved ...
 23-137 2.98e-03

methyltransferase, FkbM family; Members of this family are characterized by two well-conserved short regions separated by a variable in both sequence and length. The first of the two regions is found in a large number of proteins outside this subfamily, a number of which have been characterized as methyltransferases. One member of the present family, FkbM, was shown to be required for a specific methylation in the biosynthesis of the immunosuppressant FK506 in Streptomyces strain MA6548.


Pssm-ID: 273628  Cd Length: 143  Bit Score: 36.52  E-value: 2.98e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1230885081  23 IVIDATCGNGFDTLFLAQHVPKGHVYGF----DIQQQAIDNtaKKIKSFKNVSLIHdsheyisdHLISAHKNKITAAIFN 98
Cdd:TIGR01444   1 VVIDVGANIGDTSLYFARKGAEGRVIAFeplpDAYEILEEN--VKLNNLPNVVLLN--------AAVGDRDGELEFNVSD 70

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1230885081  99 LG-----YLPKGDKSIVTQPESTIRAIDAIFEQLTIEGIIVVVI 137
Cdd:TIGR01444  71 DDtgnssLLPTPDADRESEIEVEVVTLDDLVEEFGLDKVDLLKI 114
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 24-140 3.77e-03

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 35.48  E-value: 3.77e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1230885081  24 VIDATCGNGFDTLFLAQHvPKGHVYGFDIQQQAIdNTAKKI---KSFKNVSLIHDSheyiSDHLISAHKNKITAAIFNLG 100
Cdd:cd02440     2 VLDLGCGTGALALALASG-PGARVTGVDISPVAL-ELARKAaaaLLADNVEVLKGD----AEELPPEADESFDVIISDPP 75

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1230885081 101 YLPkgdksivtQPESTIRAIDAIFEQLTIEGIIVVVIYHG 140
Cdd:cd02440    76 LHH--------LVEDLARFLEEARRLLKPGGVLVLTLVLA 107
 
Name Accession Description Interval E-value
rRNA_methylase pfam06962
Putative rRNA methylase; This family contains a number of putative rRNA methylases. Note that ...
 47-184 6.07e-69

Putative rRNA methylase; This family contains a number of putative rRNA methylases. Note that many family members are hypothetical proteins.


Pssm-ID: 429214  Cd Length: 137  Bit Score: 206.10  E-value: 6.07e-69
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1230885081  47 VYGFDIQQQAIDNTAKKIKSF---KNVSLIHDSHEYISDHLisahKNKITAAIFNLGYLPKGDKSIVTQPESTIRAIDAI 123
Cdd:pfam06962   1 VYAFDIQEEALENTRERLEEEgleERVELILDGHENLDEYV----PGPVDAAMFNLGYLPGGDKSITTKPETTLKALEAA 76

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1230885081 124 FEQLTIEGIIVVVIYHGHFQGKLERDALLDYFSNIDQTKAQVLQYQFINQRNDAPFICAIE 184
Cdd:pfam06962  77 LELLKPGGIISLVVYPGHPGGKEEKEAVLEYLSSLDQKKYNVLKYEFLNQPNNPPFLVLIE 137
RmsH COG0275
16S rRNA C1402 N4-methylase RsmH [Translation, ribosomal structure and biogenesis]; 16S rRNA ...
 18-100 2.57e-09

16S rRNA C1402 N4-methylase RsmH [Translation, ribosomal structure and biogenesis]; 16S rRNA C1402 N4-methylase RsmH is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 440044  Cd Length: 312  Bit Score: 55.07  E-value: 2.57e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1230885081  18 IQSDSIVIDATCGNGFDT-LFLAQHVPKGHVYGFDIQQQAIDNTAKKIKSFK-NVSLIHDSHEYISDHLISAHKNKITAA 95
Cdd:COG0275    21 PKPGGVYVDGTLGGGGHSrAILERLGPGGRLIGIDRDPDAIAAAKERLAEFGdRFTLVHGNFSELDEVLAELGIEKVDGI 100


                  ....*
gi 1230885081  96 IFNLG 100
Cdd:COG0275   101 LLDLG 105
Methyltransf_5 pfam01795
MraW methylase family; Members of this family are probably SAM dependent methyltransferases ...
 18-100 5.57e-08

MraW methylase family; Members of this family are probably SAM dependent methyltransferases based on Swiss:P18595. This family appears to be related to pfam01596.


Pssm-ID: 396387  Cd Length: 309  Bit Score: 51.18  E-value: 5.57e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1230885081  18 IQSDSIVIDATCGNGFDTLFLAQHVPKGHVYGFDIQQQAIDNTAKKIKSFKN-VSLIHDSHEYISDHLISAHKNKITAAI 96
Cdd:pfam01795  18 PKPDGVYIDCTLGGGGHSEAILEQLPELRLIGIDRDPQAIARAKERLKPFEDrVTLVHGNFRFFKEALAELGVTKVDGIL 97


                  ....
gi 1230885081  97 FNLG 100
Cdd:pfam01795  98 LDLG 101
Gcd14 COG2519
tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 ...
 1-74 3.28e-07

tRNA A58 N-methylase Trm61 [Translation, ribosomal structure and biogenesis]; tRNA A58 N-methylase Trm61 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 442009 [Multi-domain]  Cd Length: 249  Bit Score: 48.62  E-value: 3.28e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1230885081   1 MKLER----ILPFAKSLITSH--IQSDSIVIDATCGNGFDTLFLAQHV-PKGHVYGFDIQQQAIDNTAKKIKSF---KNV 70
Cdd:COG2519    66 LSMKRgtqiIYPKDAGYIIARldIFPGARVLEAGTGSGALTLALARAVgPEGKVYSYERREDFAEIARKNLERFglpDNV 145


                  ....
gi 1230885081  71 SLIH 74
Cdd:COG2519   146 ELKL 149
Methyltransf_31 pfam13847
Methyltransferase domain; This family appears to have methyltransferase activity.
 18-74 1.44e-05

Methyltransferase domain; This family appears to have methyltransferase activity.


Pssm-ID: 463998 [Multi-domain]  Cd Length: 150  Bit Score: 43.17  E-value: 1.44e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1230885081  18 IQSDSIVIDATCGNGFDTLFLAQHV-PKGHVYGFDIQQQAIDNtAKKIKS---FKNVSLIH 74
Cdd:pfam13847   1 IDKGMRVLDLGCGTGHLSFELAEELgPNAEVVGIDISEEAIEK-ARENAQklgFDNVEFEQ 60
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 24-161 3.06e-05

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 42.60  E-value: 3.06e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1230885081  24 VIDATCGNGFDTLFLAQHvPKGHVYGFDIQQQAIDNTAKKIKSFK--NVSLIHDSheyisdhlisahknkitaaIFNLGY 101
Cdd:COG0500    30 VLDLGCGTGRNLLALAAR-FGGRVIGIDLSPEAIALARARAAKAGlgNVEFLVAD-------------------LAELDP 89

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1230885081 102 LPKGDKSIVT--------QPESTIRAIDAIFEQLTIEGIIVVVIYHGHFQGKLERDALLDYFSNIDQT 161
Cdd:COG0500    90 LPAESFDLVVafgvlhhlPPEEREALLRELARALKPGGVLLLSASDAAAALSLARLLLLATASLLELL 157
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 24-74 3.99e-05

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 40.62  E-value: 3.99e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1230885081  24 VIDATCGNGFDTLFLAQHVpKGHVYGFDIQQQAIDNTAKKIKSFK-NVSLIH 74
Cdd:pfam13649   1 VLDLGCGTGRLTLALARRG-GARVTGVDLSPEMLERARERAAEAGlNVEFVQ 51
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 18-74 4.35e-05

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 41.52  E-value: 4.35e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1230885081  18 IQSDSIVIDATCGNGFDTLFLAQHVpkGHVYGFDIQQQAIDNTAKKIKSFK-NVSLIH 74
Cdd:COG2226    20 LRPGARVLDLGCGTGRLALALAERG--ARVTGVDISPEMLELARERAAEAGlNVEFVV 75
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 12-78 7.44e-04

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 37.69  E-value: 7.44e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1230885081  12 SLITSHIQSDSIVIDATCGNGFDTLFLAQHvpkGH-VYGFDIQQQAIDnTAKKIKSFKNVSLIHDSHE 78
Cdd:COG2227    16 ALLARLLPAGGRVLDVGCGTGRLALALARR---GAdVTGVDISPEALE-IARERAAELNVDFVQGDLE 79
Tam COG4106
Trans-aconitate methyltransferase [Energy production and conversion];
24-58 1.41e-03

Trans-aconitate methyltransferase [Energy production and conversion];


Pssm-ID: 443282 [Multi-domain]  Cd Length: 100  Bit Score: 36.73  E-value: 1.41e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1230885081  24 VIDATCGNGFDTLFLAQHVPKGHVYGFDIQQQAID 58
Cdd:COG4106     5 VLDLGCGTGRLTALLAERFPGARVTGVDLSPEMLA 39
fkbM_fam TIGR01444
methyltransferase, FkbM family; Members of this family are characterized by two well-conserved ...
 23-137 2.98e-03

methyltransferase, FkbM family; Members of this family are characterized by two well-conserved short regions separated by a variable in both sequence and length. The first of the two regions is found in a large number of proteins outside this subfamily, a number of which have been characterized as methyltransferases. One member of the present family, FkbM, was shown to be required for a specific methylation in the biosynthesis of the immunosuppressant FK506 in Streptomyces strain MA6548.


Pssm-ID: 273628  Cd Length: 143  Bit Score: 36.52  E-value: 2.98e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1230885081  23 IVIDATCGNGFDTLFLAQHVPKGHVYGF----DIQQQAIDNtaKKIKSFKNVSLIHdsheyisdHLISAHKNKITAAIFN 98
Cdd:TIGR01444   1 VVIDVGANIGDTSLYFARKGAEGRVIAFeplpDAYEILEEN--VKLNNLPNVVLLN--------AAVGDRDGELEFNVSD 70

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1230885081  99 LG-----YLPKGDKSIVTQPESTIRAIDAIFEQLTIEGIIVVVI 137
Cdd:TIGR01444  71 DDtgnssLLPTPDADRESEIEVEVVTLDDLVEEFGLDKVDLLKI 114
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 24-140 3.77e-03

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 35.48  E-value: 3.77e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1230885081  24 VIDATCGNGFDTLFLAQHvPKGHVYGFDIQQQAIdNTAKKI---KSFKNVSLIHDSheyiSDHLISAHKNKITAAIFNLG 100
Cdd:cd02440     2 VLDLGCGTGALALALASG-PGARVTGVDISPVAL-ELARKAaaaLLADNVEVLKGD----AEELPPEADESFDVIISDPP 75

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1230885081 101 YLPkgdksivtQPESTIRAIDAIFEQLTIEGIIVVVIYHG 140
Cdd:cd02440    76 LHH--------LVEDLARFLEEARRLLKPGGVLVLTLVLA 107
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 29-68 4.29e-03

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 35.04  E-value: 4.29e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1230885081  29 CGNGFDTLFLAQHVPKGHVYGFDIQQQAIDNTAKKIKSFK 68
Cdd:pfam08242   5 CGTGTLLRALLEALPGLEYTGLDISPAALEAARERLAALG 44
TrmA COG2265
tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure ...
 19-92 4.31e-03

tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family [Translation, ribosomal structure and biogenesis]; tRNA/tmRNA/rRNA uracil-C5-methylase, TrmA/RlmC/RlmD family is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 441866 [Multi-domain]  Cd Length: 377  Bit Score: 37.08  E-value: 4.31e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1230885081  19 QSDSIVIDATCGNGFDTLFLAQHVpkGHVYGFDIQQQAIDNtAK---KIKSFKNVSLIH-DSHEYISDHLISAHKNKI 92
Cdd:COG2265   232 TGGERVLDLYCGVGTFALPLARRA--KKVIGVEIVPEAVED-ARenaRLNGLKNVEFVAgDLEEVLPELLWGGRPDVV 306
TrmN6 COG4123
tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) ...
 24-58 5.22e-03

tRNA1(Val) A37 N6-methylase TrmN6 [Translation, ribosomal structure and biogenesis]; tRNA1(Val) A37 N6-methylase TrmN6 is part of the Pathway/BioSystem: tRNA modification


Pssm-ID: 443299 [Multi-domain]  Cd Length: 238  Bit Score: 36.28  E-value: 5.22e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1230885081  24 VIDATCGNGFDTLFLAQHVPKGHVYGFDIQQQAID 58
Cdd:COG4123    41 VLDLGTGTGVIALMLAQRSPGARITGVEIQPEAAE 75
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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