|
Name |
Accession |
Description |
Interval |
E-value |
| dnaE |
PRK05673 |
DNA polymerase III subunit alpha; Validated |
4-1164 |
0e+00 |
|
DNA polymerase III subunit alpha; Validated
Pssm-ID: 235554 [Multi-domain] Cd Length: 1135 Bit Score: 1945.28 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 4 SFVHLRLHTEYSLVDGLVRIKPLVKALAGMGMPAVAVTDQNNMCSLVKFYKTSMGAGIKPICGADLWLSNKDPDN----- 78
Cdd:PRK05673 1 RFVHLHVHSEYSLLDGAAKIKPLVKKAAELGMPAVALTDHGNLFGAVEFYKAAKGAGIKPIIGCEAYVAPEKKDDvsggg 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 79 PLSRISLLVMNAVGYRNLTELISRGFIDGQRNGQIIIEREWVAEAAEGLIMLSAAKEGEIGMALIAGDLEVAETLAREWM 158
Cdd:PRK05673 81 AYTHLTLLAKNETGYRNLFKLSSRAYLEGQYGYKPRIDREWLAEHSEGLIALSGCPSGEVGTALLAGQYDEAEEAAAEYQ 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 159 AVFPERFYLEVQRTNRPNDEEQLHAAVALADKIGAPLVATNDVRFIKQEDFEAHETRVCIGEGRALDDPRRSKNYSDQQY 238
Cdd:PRK05673 161 EIFGDRFYLELMRHGLPIERRVEHALLELAKELGLPLVATNDVHYLTPEDAEAHEALLCIAEGKTLDDPDRFRFYSPEQY 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 239 LKSAEEMAELFSDLPEALENTVEIAKRCNIEVKLGKHFLPDYPIPDGMTIDEYFRKVSFDGLEERLSVLLPkdttedyEA 318
Cdd:PRK05673 241 LKSAEEMRELFADLPEALDNTVEIAERCNVEVRLGKPFLPRFPTPDGETEEDYLRKEAKEGLEERLAFLFP-------DE 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 319 KRQVYVDRLNFELDIIIQMGFPGYFLIVMDFIQWAKSNGVPVGPGRGSGAGSLVAYVQKITDLDPLEYDLLFERFLNPER 398
Cdd:PRK05673 314 ERPEYVERLEYELDVIIQMGFPGYFLIVADFIQWAKDNGIPVGPGRGSGAGSLVAYALGITDLDPLRFGLLFERFLNPER 393
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 399 VSMPDFDVDFCMDGRDRVIDYVAEKYGRNAVSQIITFGSMAAKAVVRDVARVQGKSYGLADRLSKMIPFEVGMTLEKAYE 478
Cdd:PRK05673 394 VSMPDFDIDFCQDRRDEVIRYVAEKYGRDAVAQIITFGTMKAKAVIRDVGRVLGMPYGFVDRITKLIPPDPGITLAKAYE 473
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 479 QEEILRDFIKVDEEAAEIWEMARKLEGVVRNVGKHAGGVVIAPTKLTDFSPIYCDEEGGGLVTQFDKDDVEAAGLVKFDF 558
Cdd:PRK05673 474 EEPELRELYESDPEVKRLIDMARKLEGLTRNAGVHAAGVVISPTPLTDFVPLYRDPDSGMPVTQFDMKDVEAAGLVKFDF 553
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 559 LGLRTLTIIDWALKTINRDRAkvgeEPLDIAFIPLDDKPTYSLLQKAETTAVFQLESRGMKELIKKLKPDCLEDLIALVA 638
Cdd:PRK05673 554 LGLRTLTIIDDALKLIKKRRG----IDVDLEAIPLDDPKTYELLQRGETLGVFQLESRGMRDLLKRLKPDCFEDIIALVA 629
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 639 LFRPGPLQSGMVDDFINRKHGRAELAYPHPDyqydgLQPVLAPTYGIILYQEQVMQIAQVMAGYTLGGADMLRRAMGKKK 718
Cdd:PRK05673 630 LYRPGPMESGMIPNFIDRKHGREEIEYPHPE-----LEPILKETYGIIVYQEQVMQIAQVLAGYSLGGADLLRRAMGKKK 704
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 719 PEEMAKQRGGFIEGCASNNIDADLAGNIFDLVEKFAGYGFNKSHSAAYGLVSYQTAWLKAHYPAPFMAAVLSADMHNTDK 798
Cdd:PRK05673 705 PEEMAKQREIFVEGAKKNGIDEEAADAIFDLLEKFAGYGFNKSHAAAYALVSYQTAYLKAHYPAEFMAALLTSDMDNTDK 784
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 799 VVTLIEEVRIMKLRLDAPDVNTSEFKFTVnDEGRIVYGLGAIKGVGEGPVEAITEAREA-GPFKDLFDFCARVDLKRINK 877
Cdd:PRK05673 785 VAVYLDECRRMGIKVLPPDVNESLYDFTV-VDGDIRYGLGAIKGVGEGAVEAIVEAREEgGPFKDLFDFCARVDLKKVNK 863
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 878 RTLDGLIRSGALDRLGPhffdepkayqanidqNRAVLLAAMEEAIKAAEQTARTHDSGHADLFGGvFVDEDADVYANHRK 957
Cdd:PRK05673 864 RVLESLIKAGAFDSLGP---------------NRAALLASLEDAVDAADQHKKAEASGQFDLFGG-LGEEPEDVEVSVPD 927
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 958 AKELTLKERLKGEKDTLGLYLTGHPIDEYEGEIRRFARQRIIDLKPARDTQ--TVAGMIIALRVMKNKKGDKMGFITLDD 1035
Cdd:PRK05673 928 VEEWDKKEKLAGERETLGLYLSGHPLDGYEDELRRLRDTRLADLEPTEGGSvvTVAGLVVSVRRRVTKRGNKMAIVTLED 1007
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 1036 RSGRIEASLFADAFHSAQSLLQTDAMVVVEGEVSNDDfsGGLRLRVKRVMSMEDARTNLAESLRLKIHSDALKGDQLRWL 1115
Cdd:PRK05673 1008 LSGRIEVMLFSEALEKYRDLLEEDRIVVVKGQVSFDD--GGLRLTAREVMDLEEARAKYARPLRISLPDRQLTPQLLERL 1085
|
1130 1140 1150 1160
....*....|....*....|....*....|....*....|....*....
gi 1238823117 1116 GDLFKRHRGACPITMEYTRDDAKALLQFGENWRIDPADSLIQALRDQFG 1164
Cdd:PRK05673 1086 KQVLEPHRGTSPVHLYLQDPDAEAELRLGDRWRVTPSDALLGDLKALLG 1134
|
|
| DnaE |
COG0587 |
DNA polymerase III, alpha subunit [Replication, recombination and repair]; |
1-1085 |
0e+00 |
|
DNA polymerase III, alpha subunit [Replication, recombination and repair];
Pssm-ID: 440352 [Multi-domain] Cd Length: 1050 Bit Score: 1657.51 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 1 MPASFVHLRLHTEYSLVDGLVRIKPLVKALAGMGMPAVAVTDQNNMCSLVKFYKTSMGAGIKPICGADLWLSNKDPDNPL 80
Cdd:COG0587 1 MSPSFVHLHVHSEYSLLDGASRPEELVARAAELGMPALAITDHGNLFGAVRFYKAAKKAGIKPIIGCELYVAPGSRDDAG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 81 SRISLLVMNAVGYRNLTELISRGFIDGQRNGQIIIEREWVAEAAEGLIMLSAAKEGEIGMALIAGDLEVAETLAREWMAV 160
Cdd:COG0587 81 YHLVLLAKNREGYRNLCRLLSRAYLEGFYKGKPRIDLEDLAEHSEGLIALSGCLAGEVGQALLAGQYDEAEAALARLKDI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 161 FPERFYLEVQRTNRPNDEEQLHAAVALADKIGAPLVATNDVRFIKQEDFEAHETRVCIGEGRALDDPRRSKNYSDQQYLK 240
Cdd:COG0587 161 FGDRFYLELQRHGLPEDRRVNAALLELARELGLPLVATNDVHYLNPEDAEAHDVLLCIRTGKTLDDPGRRRFANAERYLK 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 241 SAEEMAELFSDLPEALENTVEIAKRCNIEVKLGKHFLPDYPIPDGMTIDEYFRKVSFDGLEERLSVLLPKDttedyeakr 320
Cdd:COG0587 241 SPEEMAELFADLPEALANTLEIAERCNFSLDLGKYQLPKFPVPEGETEEEYLRKLAEEGLERRYPEGIPEE--------- 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 321 qvYVDRLNFELDIIIQMGFPGYFLIVMDFIQWAKSNGVPVGPGRGSGAGSLVAYVQKITDLDPLEYDLLFERFLNPERVS 400
Cdd:COG0587 312 --YRERLEYELDVIEKMGFPGYFLIVWDFIRWARSNGIPVGPGRGSAAGSLVAYALGITDVDPIRYDLLFERFLNPERVS 389
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 401 MPDFDVDFCMDGRDRVIDYVAEKYGRNAVSQIITFGSMAAKAVVRDVARVQGKSYGLADRLSKMIPFEVGMTLEKAYEQE 480
Cdd:COG0587 390 MPDIDIDFCHERREEVIQYVYEKYGRDRVAQIATFGTMRARAAIRDVGRVLGLPYGEVDRLAKLIPNDPGITLEKALEEE 469
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 481 EILRDFIKVDEEAAEIWEMARKLEGVVRNVGKHAGGVVIAPTKLTDFSPIYCDEEGGGLVTQFDKDDVEAAGLVKFDFLG 560
Cdd:COG0587 470 PELRELYDSDPEVRRLLDLARKLEGLPRHLSTHAGGVVISDDPLTDLVPLERAAMGGRPVTQFDKDDVEALGLLKFDFLG 549
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 561 LRTLTIIDWALKTINRDRakvgEEPLDIAFIPLDDKPTYSLLQKAETTAVFQLESRGMKELIKKLKPDCLEDLIALVALF 640
Cdd:COG0587 550 LRTLTVIRDALDLIKENR----GIDIDLADIPLDDPKTYELLQRGDTIGVFQLESRGMRSLLKRLKPDCFEDLVALVALY 625
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 641 RPGPLQSGMVDDFINRKHGRAELAYPHPDyqydgLQPVLAPTYGIILYQEQVMQIAQVMAGYTLGGADMLRRAMGKKKPE 720
Cdd:COG0587 626 RPGPMQGGMVPPYIRRKHGREPVEYPHPE-----LEPILKETYGVIVYQEQVMQIAQVLAGFSLGEADLLRRAMGKKKKE 700
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 721 EMAKQRGGFIEGCASNNIDADLAGNIFDLVEKFAGYGFNKSHSAAYGLVSYQTAWLKAHYPAPFMAAVLSADMHNTDKVV 800
Cdd:COG0587 701 EMAKQREKFVEGAVANGYDEEFAEEIFDQIEKFAGYGFNKSHAAAYALLAYQTAYLKAHYPAEFMAALLNSQPMGFYKPA 780
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 801 TLIEEVRIMKLRLDAPDVNTSEFKFTVNDEGRIVYGLGAIKGVGEGPVEAITEAREA-GPFKDLFDFCARVDLKRINKRT 879
Cdd:COG0587 781 QYVQEARRHGIEVLPPDVNESDWDFTVEPGGAIRLGLGAIKGVGEAAAEAIVAAREEnGPFTSLFDFCRRVDLRKLNKRV 860
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 880 LDGLIRSGALDRLGPHffdepkayqanidqnRAVLLAAMEEAIKAAEQTARTHDSGHADLFGGvfVDEDADVYANHRKAK 959
Cdd:COG0587 861 LEALIKAGAFDSLGPN---------------RRQLLWALEAALDAAQQAQKDKASGQLSLFGG--AGDEEVAEPALPELP 923
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 960 ELTLKERLKGEKDTLGLYLTGHPIDEYEGEIRRFARQRIIDLKPARD--TQTVAGMIIALRVMKNKKGDKMGFITLDDRS 1037
Cdd:COG0587 924 EWSEKEKLAAEKEALGLYLSGHPLDLYREELRRLGVTPAADLAELRDgrRVRVAGLVTSRQRPGTKKGKRMAFVTLEDET 1003
|
1050 1060 1070 1080
....*....|....*....|....*....|....*....|....*...
gi 1238823117 1038 GRIEASLFADAFHSAQSLLQTDAMVVVEGEVSNDDfsGGLRLRVKRVM 1085
Cdd:COG0587 1004 GSIEVVVFPEVYERYRRLLLEDRLLLVRGKVQRRD--GVVHLIAERIE 1049
|
|
| polc |
TIGR00594 |
DNA-directed DNA polymerase III (polc); All proteins in this family for which functions are ... |
5-1045 |
0e+00 |
|
DNA-directed DNA polymerase III (polc); All proteins in this family for which functions are known are DNA polymerases. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273161 [Multi-domain] Cd Length: 1022 Bit Score: 1348.97 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 5 FVHLRLHTEYSLVDGLVRIKPLVKALAGMGMPAVAVTDQNNMCSLVKFYKTSMGAGIKPICGADLWLSNKDP-DNPLSRI 83
Cdd:TIGR00594 1 FVHLHVHSDYSLLDGAAKIKPLVKKAKELGMPALALTDHGNMFGAVEFYKACKKAGIKPIIGCEAYVAPGSRfDKKRISK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 84 S-------LLVMNAVGYRNLTELISRGFIDGQRNGQIIiEREWVAEAAEGLIMLSAAKEGEIGMALIAGDLEVAETLARE 156
Cdd:TIGR00594 81 GkeayhliLLAKNNTGYRNLMKLSSLAYLEGFYYKPRI-DKELLEEHSEGLIALSACLSGEVPYLLLLGEERLAEEAALK 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 157 WMAVFPERFYLEVQRTNRPNDEEQLHAAVALADKIGAPLVATNDVRFIKQEDFEAHETRVCIGEGRALDDPRRSKNYSDQ 236
Cdd:TIGR00594 160 YQEIFGDDYYLELQDHGIPEQRVVNEALLEISEELGIPLVATNDVHYINPEDAHAHEILLCIQTGKTLSDPKRLKFYSDE 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 237 QYLKSAEEMAELFSDLPEALENTVEIAKRCN-IEVKLGKHFLPDYPIP-DGMTIDEYFRKVSFDGLEERLSVLLPKdtte 314
Cdd:TIGR00594 240 FYLKSPEEMAELFADIPEALANTVEIAERCNlVDVKLGPPRLPSYQIPpDFTSQEDYLRHLADEGLRERLAAGPPG---- 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 315 dyEAKRQVYVDRLNFELDIIIQMGFPGYFLIVMDFIQWAKSNGVPVGPGRGSGAGSLVAYVQKITDLDPLEYDLLFERFL 394
Cdd:TIGR00594 316 --YKRRAQYKERLEYELDVINSMGFPGYFLIVWDFIKWAKDHGIPVGPGRGSAAGSLVAYALKITDIDPIKHGLLFERFL 393
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 395 NPERVSMPDFDVDFCMDGRDRVIDYVAEKYGRNAVSQIITFGSMAAKAVVRDVARVQGKSYGLADRLSKMIPFEVGMTLE 474
Cdd:TIGR00594 394 NPERISMPDIDIDFCDERRDEVIEYVADKYGHDNVAQIITFGTMKAKAALRDVARVLDIPYAEADRIAKLIPPRPGKTLK 473
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 475 KAYEQEEILRDFIKVDEEAAEIWEMARKLEGVVRNVGKHAGGVVIAPTKLTDFSPIYCDEEGGGLVTQFDKDDVEAAGLV 554
Cdd:TIGR00594 474 EALEASPQLRQLYEEDPEVKQLIDMARKLEGLNRNAGVHAAGVVISSEPLTDYVPLYKDKEGGAISTQYDMDDLEAVGLL 553
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 555 KFDFLGLRTLTIIDWALKTINrdraKVGEEPLDIAFIPLDDKPTYSLLQKAETTAVFQLESRGMKELIKKLKPDCLEDLI 634
Cdd:TIGR00594 554 KMDFLGLKTLTLIQDATELIR----KRRGIDLDIASIPLDDKKTFSLLQEGDTTGVFQLESRGMQDLLKRLKPDGFEDII 629
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 635 ALVALFRPGPLQSGMVDDFINRKHGRAELAYPHPDyqydgLQPVLAPTYGIILYQEQVMQIAQVMAGYTLGGADMLRRAM 714
Cdd:TIGR00594 630 AVNALYRPGPMESGMIPDFIDRKHGREPIEYPHPL-----LEPILKETYGVIVYQEQVMQIAQRLAGFSLGEADLLRRAM 704
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 715 GKKKPEEMAKQRGGFIEGCASNNIDADLAGNIFDLVEKFAGYGFNKSHSAAYGLVSYQTAWLKAHYPAPFMAAVLSADMH 794
Cdd:TIGR00594 705 GKKKAEEMAKEREKFVEGAEKNGYDPEIAENLFDLIEKFAGYGFNKSHAAAYGMISYQTAYLKANYPAEFMAALLTSEIN 784
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 795 NTDKVVTLIEEVRIMKLRLDAPDVNTSEFKFTVNDeGRIVYGLGAIKGVGEGPVEAITEAREA-GPFKDLFDFCARVDLK 873
Cdd:TIGR00594 785 DIEKVAVYIAEAKKMGIEVLPPDINESGQDFAVED-KGIRYGLGAIKGVGESVVKSIIEERNKnGPFKSLFDFINRVDFK 863
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 874 RINKRTLDGLIRSGALDRLGPhffdepkayqanidqNRAVLLAAMEEAIKAAEQTARTHDSGHADLFgGVFVDEDADVYA 953
Cdd:TIGR00594 864 KLNKKVLEALIKAGAFDSLGP---------------NRKTLLASLDDALDAVSRKKKAEALGQNSLF-GALSEGTKPEYV 927
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 954 NHRKAKELTLKERLKGEKDTLGLYLTGHPIDEYEGEIRRFAR-QRIIDLKPARDTQ--TVAGMIIALRVMKNKKGDKMGF 1030
Cdd:TIGR00594 928 FFPPDEEWPDKKLLALEKETLGLYVSGHPLDAYEKALKNTATpAAIEDLEAPNDSQvrTLGGLNSVKKKITTKNGKPMAF 1007
|
1050
....*....|....*
gi 1238823117 1031 ITLDDRSGRIEASLF 1045
Cdd:TIGR00594 1008 LQLEDETGSIEVVVF 1022
|
|
| PHP_PolIIIA_DnaE1 |
cd07433 |
Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III ... |
4-280 |
1.96e-163 |
|
Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; PolIIIAs that contain an N-terminal PHP domain have been classified into four basic groups based on genome composition, phylogenetic, and domain structural analysis: polC, dnaE1, dnaE2, and dnaE3. The PHP (also called histidinol phosphatase-2/HIS2) domain is associated with several types of DNA polymerases, such as PolIIIA and family X DNA polymerases, stand alone histidinol phosphate phosphatases (HisPPases), and a number of uncharacterized protein families. DNA polymerase III holoenzyme is one of the five eubacterial DNA polymerases that are responsible for the replication of the DNA duplex. PolIIIA core enzyme catalyzes the reaction for polymerizing both DNA strands. dnaE1 is the longest compared to dnaE2 and dnaE3. A unique motif was also identified in dnaE1 and dnaE3 genes.
Pssm-ID: 213988 [Multi-domain] Cd Length: 277 Bit Score: 485.44 E-value: 1.96e-163
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 4 SFVHLRLHTEYSLVDGLVRIKPLVKALAGMGMPAVAVTDQNNMCSLVKFYKTSMGAGIKPICGADLWLSNKDPDNPLSRI 83
Cdd:cd07433 1 SFVHLRVHSEYSLLDGAVRIKKLVKLAKEDGMPALAITDLSNLFGAVKFYKAASKAGIKPIIGADLNVANPDDADEPFRL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 84 SLLVMNAVGYRNLTELISRGFIDGQRNGQIIIEREWVAEAAEGLIMLSAAKEGEIGMALIAGDLEVAETLAREWMAVFPE 163
Cdd:cd07433 81 TLLAQNEQGYKNLTELISRAYLEGQRNGGPHIKLEWLAEYSEGLIALSGGRDGDIGQLLLEGNPDLAEALLQFLKKIFPD 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 164 RFYLEVQRTNRPNDEEQLHAAVALADKIGAPLVATNDVRFIKQEDFEAHETRVCIGEGRALDDPRRSKNYSDQQYLKSAE 243
Cdd:cd07433 161 RFYLELQRHGRPEEEAYEHALIDLAYELGLPLVATNDVRFLKPEDFEAHEARVCIAEGRTLDDPRRPRRYSPQQYFKSAE 240
|
250 260 270
....*....|....*....|....*....|....*..
gi 1238823117 244 EMAELFSDLPEALENTVEIAKRCNIEVKLGKHFLPDY 280
Cdd:cd07433 241 EMAELFADLPEAIENTVEIAKRCNVRIELGKPFLPDF 277
|
|
| DNA_pol3_alpha |
pfam07733 |
Bacterial DNA polymerase III alpha NTPase domain; |
290-560 |
2.26e-137 |
|
Bacterial DNA polymerase III alpha NTPase domain;
Pssm-ID: 400196 [Multi-domain] Cd Length: 259 Bit Score: 416.52 E-value: 2.26e-137
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 290 EYFRKVSFDGLEERLSVLLPKDttedyeakrqvYVDRLNFELDIIIQMGFPGYFLIVMDFIQWAKSNGVPVGPGRGSGAG 369
Cdd:pfam07733 1 EYLRKLVEEGLKERYGEGLPEE-----------YQERLEYELNVIIKMGFAGYFLIVWDLVKWAKDNGILVGPGRGSAAG 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 370 SLVAYVQKITDLDPLEYDLLFERFLNPERVSMPDFDVDFCMDGRDRVIDYVAEKYGRNAVSQIITFGSMAAKAVVRDVAR 449
Cdd:pfam07733 70 SLVAYLLGITEVDPLKHDLLFERFLNPERVSMPDIDIDFEDERREEVIDYVKEKYGRDRVAQIATFGTYAAKSAIRDVGR 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 450 VQGKSYGLADRLSKMIPFEVGMtLEKAYEQEEILRDFIKVDEEAAEIWEMARKLEGVVRNVGKHAGGVVIAPTKLTDFSP 529
Cdd:pfam07733 150 ALGLPYDEIDRLAKLIPFELGI-LEKALEEEPELKELIESDPEVKRLIELAKKLEGLPRHTGQHAGGVVISPDPLTDFVP 228
|
250 260 270
....*....|....*....|....*....|.
gi 1238823117 530 IYCDEEGGGLVTQFDKDDVEAAGLVKFDFLG 560
Cdd:pfam07733 229 LYKADDDDRPVTQFDKDDLEDLGLLKMDFLG 259
|
|
| POLIIIAc |
smart00481 |
DNA polymerase alpha chain like domain; DNA polymerase alpha chain like domain, incl. family ... |
7-71 |
2.67e-20 |
|
DNA polymerase alpha chain like domain; DNA polymerase alpha chain like domain, incl. family of hypothetical proteins
Pssm-ID: 197753 [Multi-domain] Cd Length: 67 Bit Score: 85.78 E-value: 2.67e-20
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1238823117 7 HLRLHTEYSLVDGLVRIKPLVKALAGMGMPAVAVTDQNNMCSLVKFYKTSMGAGIKPICGADLWL 71
Cdd:smart00481 1 DLHVHSDYSLLDGALSPEELVKRAKELGLKAIAITDHGNLFGAVEFYKAAKKAGIKPIIGLEANI 65
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| dnaE |
PRK05673 |
DNA polymerase III subunit alpha; Validated |
4-1164 |
0e+00 |
|
DNA polymerase III subunit alpha; Validated
Pssm-ID: 235554 [Multi-domain] Cd Length: 1135 Bit Score: 1945.28 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 4 SFVHLRLHTEYSLVDGLVRIKPLVKALAGMGMPAVAVTDQNNMCSLVKFYKTSMGAGIKPICGADLWLSNKDPDN----- 78
Cdd:PRK05673 1 RFVHLHVHSEYSLLDGAAKIKPLVKKAAELGMPAVALTDHGNLFGAVEFYKAAKGAGIKPIIGCEAYVAPEKKDDvsggg 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 79 PLSRISLLVMNAVGYRNLTELISRGFIDGQRNGQIIIEREWVAEAAEGLIMLSAAKEGEIGMALIAGDLEVAETLAREWM 158
Cdd:PRK05673 81 AYTHLTLLAKNETGYRNLFKLSSRAYLEGQYGYKPRIDREWLAEHSEGLIALSGCPSGEVGTALLAGQYDEAEEAAAEYQ 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 159 AVFPERFYLEVQRTNRPNDEEQLHAAVALADKIGAPLVATNDVRFIKQEDFEAHETRVCIGEGRALDDPRRSKNYSDQQY 238
Cdd:PRK05673 161 EIFGDRFYLELMRHGLPIERRVEHALLELAKELGLPLVATNDVHYLTPEDAEAHEALLCIAEGKTLDDPDRFRFYSPEQY 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 239 LKSAEEMAELFSDLPEALENTVEIAKRCNIEVKLGKHFLPDYPIPDGMTIDEYFRKVSFDGLEERLSVLLPkdttedyEA 318
Cdd:PRK05673 241 LKSAEEMRELFADLPEALDNTVEIAERCNVEVRLGKPFLPRFPTPDGETEEDYLRKEAKEGLEERLAFLFP-------DE 313
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 319 KRQVYVDRLNFELDIIIQMGFPGYFLIVMDFIQWAKSNGVPVGPGRGSGAGSLVAYVQKITDLDPLEYDLLFERFLNPER 398
Cdd:PRK05673 314 ERPEYVERLEYELDVIIQMGFPGYFLIVADFIQWAKDNGIPVGPGRGSGAGSLVAYALGITDLDPLRFGLLFERFLNPER 393
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 399 VSMPDFDVDFCMDGRDRVIDYVAEKYGRNAVSQIITFGSMAAKAVVRDVARVQGKSYGLADRLSKMIPFEVGMTLEKAYE 478
Cdd:PRK05673 394 VSMPDFDIDFCQDRRDEVIRYVAEKYGRDAVAQIITFGTMKAKAVIRDVGRVLGMPYGFVDRITKLIPPDPGITLAKAYE 473
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 479 QEEILRDFIKVDEEAAEIWEMARKLEGVVRNVGKHAGGVVIAPTKLTDFSPIYCDEEGGGLVTQFDKDDVEAAGLVKFDF 558
Cdd:PRK05673 474 EEPELRELYESDPEVKRLIDMARKLEGLTRNAGVHAAGVVISPTPLTDFVPLYRDPDSGMPVTQFDMKDVEAAGLVKFDF 553
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 559 LGLRTLTIIDWALKTINRDRAkvgeEPLDIAFIPLDDKPTYSLLQKAETTAVFQLESRGMKELIKKLKPDCLEDLIALVA 638
Cdd:PRK05673 554 LGLRTLTIIDDALKLIKKRRG----IDVDLEAIPLDDPKTYELLQRGETLGVFQLESRGMRDLLKRLKPDCFEDIIALVA 629
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 639 LFRPGPLQSGMVDDFINRKHGRAELAYPHPDyqydgLQPVLAPTYGIILYQEQVMQIAQVMAGYTLGGADMLRRAMGKKK 718
Cdd:PRK05673 630 LYRPGPMESGMIPNFIDRKHGREEIEYPHPE-----LEPILKETYGIIVYQEQVMQIAQVLAGYSLGGADLLRRAMGKKK 704
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 719 PEEMAKQRGGFIEGCASNNIDADLAGNIFDLVEKFAGYGFNKSHSAAYGLVSYQTAWLKAHYPAPFMAAVLSADMHNTDK 798
Cdd:PRK05673 705 PEEMAKQREIFVEGAKKNGIDEEAADAIFDLLEKFAGYGFNKSHAAAYALVSYQTAYLKAHYPAEFMAALLTSDMDNTDK 784
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 799 VVTLIEEVRIMKLRLDAPDVNTSEFKFTVnDEGRIVYGLGAIKGVGEGPVEAITEAREA-GPFKDLFDFCARVDLKRINK 877
Cdd:PRK05673 785 VAVYLDECRRMGIKVLPPDVNESLYDFTV-VDGDIRYGLGAIKGVGEGAVEAIVEAREEgGPFKDLFDFCARVDLKKVNK 863
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 878 RTLDGLIRSGALDRLGPhffdepkayqanidqNRAVLLAAMEEAIKAAEQTARTHDSGHADLFGGvFVDEDADVYANHRK 957
Cdd:PRK05673 864 RVLESLIKAGAFDSLGP---------------NRAALLASLEDAVDAADQHKKAEASGQFDLFGG-LGEEPEDVEVSVPD 927
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 958 AKELTLKERLKGEKDTLGLYLTGHPIDEYEGEIRRFARQRIIDLKPARDTQ--TVAGMIIALRVMKNKKGDKMGFITLDD 1035
Cdd:PRK05673 928 VEEWDKKEKLAGERETLGLYLSGHPLDGYEDELRRLRDTRLADLEPTEGGSvvTVAGLVVSVRRRVTKRGNKMAIVTLED 1007
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 1036 RSGRIEASLFADAFHSAQSLLQTDAMVVVEGEVSNDDfsGGLRLRVKRVMSMEDARTNLAESLRLKIHSDALKGDQLRWL 1115
Cdd:PRK05673 1008 LSGRIEVMLFSEALEKYRDLLEEDRIVVVKGQVSFDD--GGLRLTAREVMDLEEARAKYARPLRISLPDRQLTPQLLERL 1085
|
1130 1140 1150 1160
....*....|....*....|....*....|....*....|....*....
gi 1238823117 1116 GDLFKRHRGACPITMEYTRDDAKALLQFGENWRIDPADSLIQALRDQFG 1164
Cdd:PRK05673 1086 KQVLEPHRGTSPVHLYLQDPDAEAELRLGDRWRVTPSDALLGDLKALLG 1134
|
|
| DnaE |
COG0587 |
DNA polymerase III, alpha subunit [Replication, recombination and repair]; |
1-1085 |
0e+00 |
|
DNA polymerase III, alpha subunit [Replication, recombination and repair];
Pssm-ID: 440352 [Multi-domain] Cd Length: 1050 Bit Score: 1657.51 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 1 MPASFVHLRLHTEYSLVDGLVRIKPLVKALAGMGMPAVAVTDQNNMCSLVKFYKTSMGAGIKPICGADLWLSNKDPDNPL 80
Cdd:COG0587 1 MSPSFVHLHVHSEYSLLDGASRPEELVARAAELGMPALAITDHGNLFGAVRFYKAAKKAGIKPIIGCELYVAPGSRDDAG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 81 SRISLLVMNAVGYRNLTELISRGFIDGQRNGQIIIEREWVAEAAEGLIMLSAAKEGEIGMALIAGDLEVAETLAREWMAV 160
Cdd:COG0587 81 YHLVLLAKNREGYRNLCRLLSRAYLEGFYKGKPRIDLEDLAEHSEGLIALSGCLAGEVGQALLAGQYDEAEAALARLKDI 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 161 FPERFYLEVQRTNRPNDEEQLHAAVALADKIGAPLVATNDVRFIKQEDFEAHETRVCIGEGRALDDPRRSKNYSDQQYLK 240
Cdd:COG0587 161 FGDRFYLELQRHGLPEDRRVNAALLELARELGLPLVATNDVHYLNPEDAEAHDVLLCIRTGKTLDDPGRRRFANAERYLK 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 241 SAEEMAELFSDLPEALENTVEIAKRCNIEVKLGKHFLPDYPIPDGMTIDEYFRKVSFDGLEERLSVLLPKDttedyeakr 320
Cdd:COG0587 241 SPEEMAELFADLPEALANTLEIAERCNFSLDLGKYQLPKFPVPEGETEEEYLRKLAEEGLERRYPEGIPEE--------- 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 321 qvYVDRLNFELDIIIQMGFPGYFLIVMDFIQWAKSNGVPVGPGRGSGAGSLVAYVQKITDLDPLEYDLLFERFLNPERVS 400
Cdd:COG0587 312 --YRERLEYELDVIEKMGFPGYFLIVWDFIRWARSNGIPVGPGRGSAAGSLVAYALGITDVDPIRYDLLFERFLNPERVS 389
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 401 MPDFDVDFCMDGRDRVIDYVAEKYGRNAVSQIITFGSMAAKAVVRDVARVQGKSYGLADRLSKMIPFEVGMTLEKAYEQE 480
Cdd:COG0587 390 MPDIDIDFCHERREEVIQYVYEKYGRDRVAQIATFGTMRARAAIRDVGRVLGLPYGEVDRLAKLIPNDPGITLEKALEEE 469
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 481 EILRDFIKVDEEAAEIWEMARKLEGVVRNVGKHAGGVVIAPTKLTDFSPIYCDEEGGGLVTQFDKDDVEAAGLVKFDFLG 560
Cdd:COG0587 470 PELRELYDSDPEVRRLLDLARKLEGLPRHLSTHAGGVVISDDPLTDLVPLERAAMGGRPVTQFDKDDVEALGLLKFDFLG 549
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 561 LRTLTIIDWALKTINRDRakvgEEPLDIAFIPLDDKPTYSLLQKAETTAVFQLESRGMKELIKKLKPDCLEDLIALVALF 640
Cdd:COG0587 550 LRTLTVIRDALDLIKENR----GIDIDLADIPLDDPKTYELLQRGDTIGVFQLESRGMRSLLKRLKPDCFEDLVALVALY 625
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 641 RPGPLQSGMVDDFINRKHGRAELAYPHPDyqydgLQPVLAPTYGIILYQEQVMQIAQVMAGYTLGGADMLRRAMGKKKPE 720
Cdd:COG0587 626 RPGPMQGGMVPPYIRRKHGREPVEYPHPE-----LEPILKETYGVIVYQEQVMQIAQVLAGFSLGEADLLRRAMGKKKKE 700
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 721 EMAKQRGGFIEGCASNNIDADLAGNIFDLVEKFAGYGFNKSHSAAYGLVSYQTAWLKAHYPAPFMAAVLSADMHNTDKVV 800
Cdd:COG0587 701 EMAKQREKFVEGAVANGYDEEFAEEIFDQIEKFAGYGFNKSHAAAYALLAYQTAYLKAHYPAEFMAALLNSQPMGFYKPA 780
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 801 TLIEEVRIMKLRLDAPDVNTSEFKFTVNDEGRIVYGLGAIKGVGEGPVEAITEAREA-GPFKDLFDFCARVDLKRINKRT 879
Cdd:COG0587 781 QYVQEARRHGIEVLPPDVNESDWDFTVEPGGAIRLGLGAIKGVGEAAAEAIVAAREEnGPFTSLFDFCRRVDLRKLNKRV 860
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 880 LDGLIRSGALDRLGPHffdepkayqanidqnRAVLLAAMEEAIKAAEQTARTHDSGHADLFGGvfVDEDADVYANHRKAK 959
Cdd:COG0587 861 LEALIKAGAFDSLGPN---------------RRQLLWALEAALDAAQQAQKDKASGQLSLFGG--AGDEEVAEPALPELP 923
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 960 ELTLKERLKGEKDTLGLYLTGHPIDEYEGEIRRFARQRIIDLKPARD--TQTVAGMIIALRVMKNKKGDKMGFITLDDRS 1037
Cdd:COG0587 924 EWSEKEKLAAEKEALGLYLSGHPLDLYREELRRLGVTPAADLAELRDgrRVRVAGLVTSRQRPGTKKGKRMAFVTLEDET 1003
|
1050 1060 1070 1080
....*....|....*....|....*....|....*....|....*...
gi 1238823117 1038 GRIEASLFADAFHSAQSLLQTDAMVVVEGEVSNDDfsGGLRLRVKRVM 1085
Cdd:COG0587 1004 GSIEVVVFPEVYERYRRLLLEDRLLLVRGKVQRRD--GVVHLIAERIE 1049
|
|
| polc |
TIGR00594 |
DNA-directed DNA polymerase III (polc); All proteins in this family for which functions are ... |
5-1045 |
0e+00 |
|
DNA-directed DNA polymerase III (polc); All proteins in this family for which functions are known are DNA polymerases. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273161 [Multi-domain] Cd Length: 1022 Bit Score: 1348.97 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 5 FVHLRLHTEYSLVDGLVRIKPLVKALAGMGMPAVAVTDQNNMCSLVKFYKTSMGAGIKPICGADLWLSNKDP-DNPLSRI 83
Cdd:TIGR00594 1 FVHLHVHSDYSLLDGAAKIKPLVKKAKELGMPALALTDHGNMFGAVEFYKACKKAGIKPIIGCEAYVAPGSRfDKKRISK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 84 S-------LLVMNAVGYRNLTELISRGFIDGQRNGQIIiEREWVAEAAEGLIMLSAAKEGEIGMALIAGDLEVAETLARE 156
Cdd:TIGR00594 81 GkeayhliLLAKNNTGYRNLMKLSSLAYLEGFYYKPRI-DKELLEEHSEGLIALSACLSGEVPYLLLLGEERLAEEAALK 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 157 WMAVFPERFYLEVQRTNRPNDEEQLHAAVALADKIGAPLVATNDVRFIKQEDFEAHETRVCIGEGRALDDPRRSKNYSDQ 236
Cdd:TIGR00594 160 YQEIFGDDYYLELQDHGIPEQRVVNEALLEISEELGIPLVATNDVHYINPEDAHAHEILLCIQTGKTLSDPKRLKFYSDE 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 237 QYLKSAEEMAELFSDLPEALENTVEIAKRCN-IEVKLGKHFLPDYPIP-DGMTIDEYFRKVSFDGLEERLSVLLPKdtte 314
Cdd:TIGR00594 240 FYLKSPEEMAELFADIPEALANTVEIAERCNlVDVKLGPPRLPSYQIPpDFTSQEDYLRHLADEGLRERLAAGPPG---- 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 315 dyEAKRQVYVDRLNFELDIIIQMGFPGYFLIVMDFIQWAKSNGVPVGPGRGSGAGSLVAYVQKITDLDPLEYDLLFERFL 394
Cdd:TIGR00594 316 --YKRRAQYKERLEYELDVINSMGFPGYFLIVWDFIKWAKDHGIPVGPGRGSAAGSLVAYALKITDIDPIKHGLLFERFL 393
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 395 NPERVSMPDFDVDFCMDGRDRVIDYVAEKYGRNAVSQIITFGSMAAKAVVRDVARVQGKSYGLADRLSKMIPFEVGMTLE 474
Cdd:TIGR00594 394 NPERISMPDIDIDFCDERRDEVIEYVADKYGHDNVAQIITFGTMKAKAALRDVARVLDIPYAEADRIAKLIPPRPGKTLK 473
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 475 KAYEQEEILRDFIKVDEEAAEIWEMARKLEGVVRNVGKHAGGVVIAPTKLTDFSPIYCDEEGGGLVTQFDKDDVEAAGLV 554
Cdd:TIGR00594 474 EALEASPQLRQLYEEDPEVKQLIDMARKLEGLNRNAGVHAAGVVISSEPLTDYVPLYKDKEGGAISTQYDMDDLEAVGLL 553
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 555 KFDFLGLRTLTIIDWALKTINrdraKVGEEPLDIAFIPLDDKPTYSLLQKAETTAVFQLESRGMKELIKKLKPDCLEDLI 634
Cdd:TIGR00594 554 KMDFLGLKTLTLIQDATELIR----KRRGIDLDIASIPLDDKKTFSLLQEGDTTGVFQLESRGMQDLLKRLKPDGFEDII 629
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 635 ALVALFRPGPLQSGMVDDFINRKHGRAELAYPHPDyqydgLQPVLAPTYGIILYQEQVMQIAQVMAGYTLGGADMLRRAM 714
Cdd:TIGR00594 630 AVNALYRPGPMESGMIPDFIDRKHGREPIEYPHPL-----LEPILKETYGVIVYQEQVMQIAQRLAGFSLGEADLLRRAM 704
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 715 GKKKPEEMAKQRGGFIEGCASNNIDADLAGNIFDLVEKFAGYGFNKSHSAAYGLVSYQTAWLKAHYPAPFMAAVLSADMH 794
Cdd:TIGR00594 705 GKKKAEEMAKEREKFVEGAEKNGYDPEIAENLFDLIEKFAGYGFNKSHAAAYGMISYQTAYLKANYPAEFMAALLTSEIN 784
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 795 NTDKVVTLIEEVRIMKLRLDAPDVNTSEFKFTVNDeGRIVYGLGAIKGVGEGPVEAITEAREA-GPFKDLFDFCARVDLK 873
Cdd:TIGR00594 785 DIEKVAVYIAEAKKMGIEVLPPDINESGQDFAVED-KGIRYGLGAIKGVGESVVKSIIEERNKnGPFKSLFDFINRVDFK 863
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 874 RINKRTLDGLIRSGALDRLGPhffdepkayqanidqNRAVLLAAMEEAIKAAEQTARTHDSGHADLFgGVFVDEDADVYA 953
Cdd:TIGR00594 864 KLNKKVLEALIKAGAFDSLGP---------------NRKTLLASLDDALDAVSRKKKAEALGQNSLF-GALSEGTKPEYV 927
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 954 NHRKAKELTLKERLKGEKDTLGLYLTGHPIDEYEGEIRRFAR-QRIIDLKPARDTQ--TVAGMIIALRVMKNKKGDKMGF 1030
Cdd:TIGR00594 928 FFPPDEEWPDKKLLALEKETLGLYVSGHPLDAYEKALKNTATpAAIEDLEAPNDSQvrTLGGLNSVKKKITTKNGKPMAF 1007
|
1050
....*....|....*
gi 1238823117 1031 ITLDDRSGRIEASLF 1045
Cdd:TIGR00594 1008 LQLEDETGSIEVVVF 1022
|
|
| dnaE |
PRK06826 |
DNA polymerase III DnaE; Reviewed |
1-1168 |
0e+00 |
|
DNA polymerase III DnaE; Reviewed
Pssm-ID: 235868 [Multi-domain] Cd Length: 1151 Bit Score: 1240.93 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 1 MPASFVHLRLHTEYSLVDGLVRIKPLVKALAGMGMPAVAVTDQNNMCSLVKFYKTSMGAGIKPICGADLWLSNK------ 74
Cdd:PRK06826 1 MKMSFVHLHVHTEYSLLDGSARIKDLIKRAKELGMDSIAITDHGVMYGVVDFYKAAKKQGIKPIIGCEVYVAPRsrfdke 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 75 -DPDNPLSRISLLVMNAVGYRNLTELISRGFIDG----QRngqiiIEREWVAEAAEGLIMLSAAKEGEIGMALIAGDLEV 149
Cdd:PRK06826 81 pDIDNETYHLVLLAKNETGYKNLMKIVSKAFTEGfyykPR-----VDHELLKEHSEGLIALSACLAGEVPRYILKGNYEK 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 150 AETLAREWMAVF-PERFYLEVQRTNRPNDEEQLHAAVALADKIGAPLVATNDVRFIKQEDFEAHETRVCIGEGRALDDPR 228
Cdd:PRK06826 156 AKEAALFYKDIFgKENFYLELQDHGIPEQRKVNEELIKLSKELGIPLVATNDVHYIRKEDAKAHDVLLCIQTGKTVDDEN 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 229 RSKNYSDQQYLKSAEEMAELFSDLPEALENTVEIAKRCNIEVKLGKHFLPDYPIPDGMTIDEYFRKVSFDGLEERlsvll 308
Cdd:PRK06826 236 RMRFPSDEFYLKSPEEMYELFSYVPEALENTVKIAERCNVEFEFGKSKLPKFPLPEGYDPYEYLRELCYEGLKKR----- 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 309 pkdttedYEAKRQVYVDRLNFELDIIIQMGFPGYFLIVMDFIQWAKSNGVPVGPGRGSGAGSLVAYVQKITDLDPLEYDL 388
Cdd:PRK06826 311 -------YPNPSEELIERLEYELSVIKQMGYVDYFLIVWDFIRFARENGIMVGPGRGSAAGSLVAYTLGITKIDPIKYNL 383
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 389 LFERFLNPERVSMPDFDVDFCMDGRDRVIDYVAEKYGRNAVSQIITFGSMAAKAVVRDVARVQGKSYGLADRLSKMIPFE 468
Cdd:PRK06826 384 LFERFLNPERVSMPDIDIDFCYERRQEVIDYVVEKYGKDRVAQIITFGTMAARAAIRDVGRALNYPYAEVDRIAKMIPTE 463
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 469 VGMTLEKAYEQEEILRDFIKVDEEAAEIWEMARKLEGVVRNVGKHAGGVVIAPTKLTDFSPIYCDEegGGLVTQFDKDDV 548
Cdd:PRK06826 464 LGITIDKALELNPELKEAYENDERVRELIDTARALEGLPRHASTHAAGVVISSEPLVEYVPLQKND--GSIVTQFTMTTL 541
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 549 EAAGLVKFDFLGLRTLTIIDWALKTINRDRakvgEEPLDIAFIPLDDKPTYSLLQKAETTAVFQLESRGMKELIKKLKPD 628
Cdd:PRK06826 542 EELGLLKMDFLGLRTLTVIRDAVDLIKKNR----GIEIDLDKIDYDDKKVYKMIGEGKTVGVFQLESAGMRSFMKELKPD 617
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 629 CLEDLIALVALFRPGPLQSgmVDDFINRKHGRAELAYPHPDyqydgLQPVLAPTYGIILYQEQVMQIAQVMAGYTLGGAD 708
Cdd:PRK06826 618 SLEDIIAGISLYRPGPMDS--IPRYIKNKNNPEKIEYLHPK-----LEPILKVTYGCIVYQEQVMQIVRDLAGYSMGRSD 690
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 709 MLRRAMGKKKPEEMAKQRGGFIEG--------CASNNIDADLAGNIFDLVEKFAGYGFNKSHSAAYGLVSYQTAWLKAHY 780
Cdd:PRK06826 691 LVRRAMSKKKHDVMEEERKNFIYGivdeggpgCIRNGIDEETANKIFDSMMDFASYAFNKSHAAAYAVVAYQTAYLKRYY 770
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 781 PAPFMAAVLSADMHNTDKVVTLIEEVRIMKLRLDAPDVNTSEFKFTVNDeGRIVYGLGAIKGVGEGPVEAITEAREA-GP 859
Cdd:PRK06826 771 PVEFMAALLNSVMGNSDKVAFYIEECRRLGIEVLPPDINESYSKFTVEG-DKIRFGLAAVKNVGENAIDSIVEEREKkGK 849
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 860 FKDLFDFCARVDLKRINKRTLDGLIRSGALDRLGPhffdepkayqanidqNRAVLLAAMEEAIKAAEQTARTHDSGHADL 939
Cdd:PRK06826 850 FKSLVDFCERVDTSQINKRAVESLIKAGAFDSLGV---------------YRSQLLAVYEKILDSISKQRKKNIEGQISL 914
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 940 FGGVFVDEDADVYANHRKAKELTLKERLKGEKDTLGLYLTGHPIDEYEGEIRRFARQRIIDLKPAR-----------DTQ 1008
Cdd:PRK06826 915 FDLIGEEEESSLEIKYPDIKEFDKKELLAMEKEMLGLYISGHPLEEYEETLKKQTSATISDIISDEeedgesklkdgDKV 994
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 1009 TVAGMIIALRVMKNKKGDKMGFITLDDRSGRIEASLFADAFHSAQSLLQTDAMVVVEGEVSNDDfSGGLRLRVKRVMSME 1088
Cdd:PRK06826 995 IIGGIITEVKRKTTRNNEMMAFLTLEDLYGTVEVIVFPKVYEKYRSLLNEDNIVLIKGRVSLRE-DEEPKLICEEIEPLV 1073
|
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 1089 DartNLAESLRLKIHSDALKGDQLRWLGDLFKRHRGACPITMeYTRDDaKALLQFGENWRIDPADSLIQALRDQFGRDNV 1168
Cdd:PRK06826 1074 I---NSEKKLYLRVEDKKDIKLKLKELKEILKQYPGNTPVYL-YTEKE-RKKFKLDRELWVNLSPELINELKELLGEENV 1148
|
|
| dnaE |
PRK07374 |
DNA polymerase III subunit alpha; Validated |
4-1162 |
0e+00 |
|
DNA polymerase III subunit alpha; Validated
Pssm-ID: 168927 [Multi-domain] Cd Length: 1170 Bit Score: 965.34 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 4 SFVHLRLHTEYSLVDGLVRIKPLVKALAGMGMPAVAVTDQNNMCSLVKFYKTSMGAGIKPICGADLWLSNKDPDNPLSR- 82
Cdd:PRK07374 2 AFVPLHNHSDYSLLDGASQLPKMVERAKELGMPAIALTDHGVMYGAIELLKLCKGKGIKPIIGNEMYVINGSIDDPQPKk 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 83 -----ISLLVMNAVGYRNLTELISRGFIDGQRNGQII----IEREWVAEAAEGLIMLSAAKEGEIGMALIAGDLEVAETL 153
Cdd:PRK07374 82 ekryhLVVLAKNATGYKNLVKLTTISHLNGMRGRGIFsrpcIDKELLKQYSEGLIVSTACLGGEIPQAILRGRPDVARDV 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 154 AREWMAVFPERFYLEVQRTNRPNDEEQLHAAVALADKIGAPLVATNDVRFIKQEDFEAHETRVCIGEGRALDDPRRSKnY 233
Cdd:PRK07374 162 AAWYKEVFGDDFYLEIQDHGSIEDRIVNVELVRIAKELGIKLIATNDAHYLSKNDVEAHDALLCVLTGKLISDEKRLR-Y 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 234 SDQQYLKSAEEMAELFSD------LPEALENTVEIAKRCNIEVKLGKHFLPDYPIPDGMTIDEYFRKVSFDGLEERLSVL 307
Cdd:PRK07374 241 TGTEYIKSEEEMLRLFRDhldpevIQEAIANTVEVAEKVEEYDILGTYRMPRFPIPEGHTAVSYLTEVTEQGLLKRLKLN 320
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 308 LPKDTTEDYEakrqvyvDRLNFELDIIIQMGFPGYFLIVMDFIQWAKSNGVPVGPGRGSGAGSLVAYVQKITDLDPLEYD 387
Cdd:PRK07374 321 SLDEIDENYK-------ERLSYELKIIEQMGFPTYFLVVWDYIRFAREQGIPVGPGRGSAAGSLVAYALGITNIDPVKNG 393
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 388 LLFERFLNPERVSMPDFDVDFCMDGRDRVIDYVAEKYGRNAVSQIITFGSMAAKAVVRDVARVQGKSYGLADRLSKMIPF 467
Cdd:PRK07374 394 LLFERFLNPERKSMPDIDTDFCIERRGEVIDYVTRRYGEDKVAQIITFNRMTSKAVLKDVARVLDIPYGEADRLAKLIPV 473
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 468 EVG-------MTLEKAYEQEeiLRDFIKVDEEAAEIWEMARKLEGVVRNVGKHAGGVVIAPTKLTDFSPIYCDEEgGGLV 540
Cdd:PRK07374 474 VRGkpaklkaMIGKESPSPE--FREKYEKDPRVKKWVDMAMRIEGTNKTFGVHAAGVVIASDPLDELVPLQRNND-GQVI 550
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 541 TQFDKDDVEAAGLVKFDFLGLRTLTIIDWALKTINRDRAkvgeEPLDIAFIPLDDKPTYSLLQKAETTAVFQLESRGMKE 620
Cdd:PRK07374 551 TQYFMEDIESLGLLKMDFLGLKNLTMIEKTLELVEQSTG----ERIDPDNLPLDDEKTFELLARGDLEGIFQLESSGMRQ 626
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 621 LIKKLKPDCLEDLIALVALFRPGPLQSGMVDDFINRKHGRAELAYPHPDyqydgLQPVLAPTYGIILYQEQVMQIAQVMA 700
Cdd:PRK07374 627 VVRDLKPSSLEDISSILALYRPGPLDAGLIPKFINRKHGREAIDFAHPL-----LEPILTETYGIMVYQEQIMKIAQDLA 701
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 701 GYTLGGADMLRRAMGKKKPEEMAKQRGGFIEGCASNNIDADLAGNIFDLVEKFAGYGFNKSHSAAYGLVSYQTAWLKAHY 780
Cdd:PRK07374 702 GYSLGQADLLRRAMGKKKVSEMQKHRGIFVEGASKRGVDEKVADELFDQMVLFAEYCFNKSHSTAYGAVTYQTAYLKAHY 781
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 781 PAPFMAAVLSADMHNTDKVVTLIEEVRIMKLRLDAPDVNTSEFKFTVNDEgRIVYGLGAIKGVGEGPVEAITEAREA-GP 859
Cdd:PRK07374 782 PVAYMAALLTVNAGSSDKVQRYISNCNSMGIEVMPPDINRSGIDFTPKGN-RILFGLSAVKNLGDGAIRNIIAARDSdGP 860
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 860 FKDLFDFCARVDLKRINKRTLDGLIRSGALDRLGPhffdepkayqaniDQNRAVLLAAMEEAIKAAEQTARTHDSGHADL 939
Cdd:PRK07374 861 FKSLADLCDRLPSNVLNRRSLESLIHCGALDAFSP-------------NANRAQLIADLDLVLDWASSRARDRASGQGNL 927
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 940 F---GGVFVDEDADVYANHRKA--KELTLKERLKGEKDTLGLYLTGHPIDEYEGEIRRFARQRIIDLKPARDTQTVA--G 1012
Cdd:PRK07374 928 FdllAGSEEEASNDLSSAPKAApvPDYPPTEKLKLEKELLGFYLSDHPLKQLTEPAKLLAPISLSSLEEQPDKAKVSaiA 1007
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 1013 MIIALRVMKNKKGDKMGFITLDDRSGRIEASLFADAFHSAQSLLQTDAMVVVEGEVsnDDFSGGLRLRVKRVMSMEDART 1092
Cdd:PRK07374 1008 MIPEMKQVTTRKGDRMAILQLEDLTGSCEAVVFPKSYERLSDHLMTDTRLLVWAKV--DRRDDRVQLIIDDCREIDDLRL 1085
|
1130 1140 1150 1160 1170 1180 1190
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1238823117 1093 NLAEsLRLKIHSDALKGDQLRwlgDLFKRHRGA-------CPITMEYTRDDAKALLQFGENWRIDPADSLIQALRDQ 1162
Cdd:PRK07374 1086 LLVE-LDPDQASDIRVQHKLR---ECLQKHRPErdelgvkIPVVAAVRNGNSVRYVRLGHQFCVKDAQAAVKALQQK 1158
|
|
| dnaE |
PRK06920 |
DNA polymerase III subunit alpha; |
4-1171 |
0e+00 |
|
DNA polymerase III subunit alpha;
Pssm-ID: 180749 [Multi-domain] Cd Length: 1107 Bit Score: 931.90 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 4 SFVHLRLHTEYSLVDGLVRIKPLVKALAGMGMPAVAVTDQNNMCSLVKFYKTSMGAGIKPICG--ADLWLSNKDPDNPLS 81
Cdd:PRK06920 2 KFVHLQCQTVFSLLKSACKIDELVVRAKELGYSSLAITDENVMYGVIPFYKACKKHGIHPIIGltASIFSEEEEKSYPLV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 82 risLLVMNAVGYRNLTElISRGFIDGQRNGqiiIEREWVAEAAEGLIMLSAAKEGEIGMALIAGDLEVAETLAREWMAVF 161
Cdd:PRK06920 82 ---LLAENEIGYQNLLK-ISSSIMTKSKEG---IPKKWLAHYAKGLIAISPGKDGEIEQLLLEDKESQAEEVARAYQNMF 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 162 PE-RFYLEVQRTNrpnDEEQLHAAV-ALADKIGAPLVATNDVRFIKQEDFEAHETRVCIGEGRALDDPRRSKNYSDQQYL 239
Cdd:PRK06920 155 GNfYMSLQHHAIQ---DELLLQEKLpEFSNRVNIPVVATNDVRYINQSDALVHECLLSVESGTKMTDPDRPRLKTDQYYL 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 240 KSAEEMAELFSDLPEALENTVEIAKRCNIEVKLGKHFLPDYPIPDGMTIDEYFRKVSFDGLEERlsvllpkdttedYEAK 319
Cdd:PRK06920 232 KSSDEMEALFSHVPEAIYNTVEIAERCRVEIPFHVNQLPKFPVPSNETADMYLRRVCEEGLQKR------------YGTP 299
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 320 RQVYVDRLNFELDIIIQMGFPGYFLIVMDFIQWAKSNGVPVGPGRGSGAGSLVAYVQKITDLDPLEYDLLFERFLNPERV 399
Cdd:PRK06920 300 KEVHINRLNHELNVISRMGFSDYFLIVWDFMKYAHENHILTGPGRGSAAGSLVSYVLEITDIDPIEYDLLFERFLNPERV 379
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 400 SMPDFDVDFCMDGRDRVIDYVAEKYGRNAVSQIITFGSMAAKAVVRDVARVQGKSYGLADRLSKMIPFEVGMTLEKAYEQ 479
Cdd:PRK06920 380 TLPDIDIDFPDTRRDEMIRYVKDKYGQLRVAQIVTFGTLAAKAAIRDIARVMGLPPRDIDIFSKLIPSKLGITLKDAYEE 459
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 480 EEILRDFIKVDEEAAEIWEMARKLEGVVRNVGKHAGGVVIAPTKLTDFSPIYcDEEGGGLVTQFDKDDVEAAGLVKFDFL 559
Cdd:PRK06920 460 SQSLREFIQGNLLHERVFEIAKRVEGLPRHTSIHAAGVIMSQEPLTGSVAIQ-EGHNDVYVTQYPADALEELGLLKMDFL 538
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 560 GLRTLTIIDWALKTINRDRAKvgeePLDIAFIPLDDKPTYSLLQKAETTAVFQLESRGMKELIKKLKPDCLEDLIALVAL 639
Cdd:PRK06920 539 GLRNLTLLENIIKFIEQKTGK----EIDIRNLPLQDEKTFQLLGRGDTTGVFQLESSGMRNVLRGLKPNEFEDIVAVNSL 614
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 640 FRPGPLQSgmVDDFINRKHGRAELAYPHPDyqydgLQPVLAPTYGIILYQEQVMQIAQVMAGYTLGGADMLRRAMGKKKP 719
Cdd:PRK06920 615 YRPGPMEQ--IPTFIESKHGKRKIEYLHPD-----LKPILERTYGVIVYQEQIMQIASKLAGFSLGEADLLRRAVSKKNR 687
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 720 EEMAKQRGGFIEGCASNNIDADLAGNIFDLVEKFAGYGFNKSHSAAYGLVSYQTAWLKAHYPAPFMAAVLSADMHNTDKV 799
Cdd:PRK06920 688 DILDQERKHFVQGCLQNGYDETSAEKIYDLIVRFANYGFNRSHAVAYSMIGYQLAYLKANYTLEFMTALLSSAIGNEDKI 767
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 800 VTLIEEVRIMKLRLDAPDVNTSEFKFTVNDeGRIVYGLGAIKGVGEGPVEAITEAREAGPFKDLFDFCARVDLKRINKRT 879
Cdd:PRK06920 768 VQYIRETKRKGFHVLPPSLQRSGYNFQIEG-NAIRYSLLSIRNIGMATVTALYEEREKKMFEDLFEFCLRMPSKFVTERN 846
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 880 LDGLIRSGALDRLGphffdepkayqanidQNRAVLLAAMEEAIKaaeqtarthdsgHADLFGGvfvDEDADVYANHRKAK 959
Cdd:PRK06920 847 LEAFVWSGCFDDFG---------------VSRTNLWKSLKGALE------------YANLARD---LGDAVPKSKYVQGE 896
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 960 ELTLKERLKGEKDTLGLYLTGHPIDEYEGEIRRFARQRIIDLKPA-RDTQTVAGMIIALRVMKNKKGDKMGFITLDDRSG 1038
Cdd:PRK06920 897 ELSFIEQLNKEKEVLGFYLSSYPTAQYVKLAKELEIPSLAQAMRHkKKVQRAIVYITSVKVIRTKKGQKMAFITFCDQND 976
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 1039 RIEASLFADAFHSAQSLLQTDAMVVVEG--EVSNDDfsggLRLRVKRVMSMEDARTNL---AESLRLKIHSDALKgDQLR 1113
Cdd:PRK06920 977 EMEAVVFPETYIHFSDKLQEGAIVLVDGtiELRNHK----LQWIVNGLYPLEEMDAYEekkDASVYVKLPSQYEK-KLLN 1051
|
1130 1140 1150 1160 1170
....*....|....*....|....*....|....*....|....*....|....*...
gi 1238823117 1114 WLGDLFKRHRGACPITMEYTRDdaKALLQFGENWRIDPADSLIQALRDQFGRDNVFLQ 1171
Cdd:PRK06920 1052 QVTKILFDYSGFAKVLIYYEKE--HKMVQLSRSLSIHPSEECLGALREIVGEENVVVK 1107
|
|
| PRK09532 |
PRK09532 |
DNA polymerase III subunit alpha; Reviewed |
4-756 |
0e+00 |
|
DNA polymerase III subunit alpha; Reviewed
Pssm-ID: 181933 [Multi-domain] Cd Length: 874 Bit Score: 639.48 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 4 SFVHLRLHTEYSLVDGLVRIKPLVKALAGMGMPAVAVTDQNNMCSLVKFYKTSMGAGIKPICGADLWLSNKDPDNPLSRI 83
Cdd:PRK09532 2 SFVGLHIHSDYSLLDGASQLPALVDRAIELGMPAIALTDHGVMYGAIELLKVCRNKGIKPIIGNEMYVINGDIEKQKRRR 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 84 S----LLVMNAVGYRNLTELISRGFIDGQRNGQII----IEREWVAEAAEGLIMLSAAKEGEIGMALIAGDLEVAETLAR 155
Cdd:PRK09532 82 KyhqvVLAKNTQGYKNLVKLTTISHLQGVQGKGIFarpcINKELLEQYHEGLIVTSACLGGEIPQAILSGRPDAARKVAK 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 156 EWMAVFPERFYLEVQRTNRPNDEEQLHAAVALADKIGAPLVATNDVRFIKQEDFEAHETRVCIGEGRALDDPRRSKnYSD 235
Cdd:PRK09532 162 WYKKLFGDDFYLEIQDHGSQEDRIVNVEIVKIARELGIKIIATNDSHFISCYDVEAHDALLCIQTGKLITEDKRLR-YSG 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 236 QQYLKSAEEMAELFSD-LP-----EALENTVEIAKRCNIEVKLGKHFLPDYPIPDGMTIDEYFRKVSFDGLEERLSVllp 309
Cdd:PRK09532 241 TEYLKSAEEMRLLFRDhLPddviaEAIANTLEVADKIEPYNILGEPRIPNYPVPSGHTPDTYVEEVAWQGLLERLNC--- 317
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 310 kdttEDYEAKRQVYVDRLNFELDIIIQMGFPGYFLIVMDFIQWAKSNGVPVGPGRGSGAGSLVAYVQKITDLDPLEYDLL 389
Cdd:PRK09532 318 ----KSRSEVEPVYKERLEYELKMLQQMGFSTYFLVVWDYIKYARDNNIPVGPGRGSAAGSLVAYCLKITNIDPVHHGLL 393
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 390 FERFLNPERVSMPDFDVDFCMDGRDRVIDYVAEKYGRNAVSQIITFGSMAAKAVVRDVARVQGKSYGLADRLSKMIPFEV 469
Cdd:PRK09532 394 FERFLNPERKSMPDIDTDFCIERRDEMIKYVTEKYGEDRVAQIITFNRMTSKAVLKDVARVLDIPYGEADKMAKLIPVSR 473
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 470 G-------MTLEKA--------YEQEEILRDFIkvdeeaaeiwEMARKLEGVVRNVGKHAGGVVIAPTKLTDFSPIYCDE 534
Cdd:PRK09532 474 GkptklkvMISDETpepefkekYDNDPRVRRWL----------DMAIRIEGTNKTFGVHAAGVVISSEPLDEIVPLQKNN 543
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 535 EgGGLVTQFDKDDVEAAGLVKFDFLGLRTLTIIDWALKTINRDRA---KVGEEPLD------------IAFIPLDDKPTY 599
Cdd:PRK09532 544 D-GAVITQYFMEDLESLGLLKMDFLGLRNLTTIQKTADLIKENRGveiDLDQLPLDerkalkilakgeAKKLPKDVQKTH 622
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 600 SLLQKAETTAVFQLESRGMKELIKKLKPDCLEDLIALVALFRPGPLQSGMVDDFINRKHGRAELayphpDYQYDGLQPVL 679
Cdd:PRK09532 623 KLLERGDLEGIFQLESSGMKQIVRDLKPSNIEDISSILALYRPGPLDAGLIPKFINRKHGREPI-----DYEHQLLEPIL 697
|
730 740 750 760 770 780 790
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1238823117 680 APTYGIILYQEQVMQIAQVMAGYTLGGADMLRRAMGKKKPEEMAKQRGGFIEGCASNNIDADLAGNIFDLVEKFAGY 756
Cdd:PRK09532 698 NETYGVLVYQEQIMKMAQDLAGYSLGEADLLRRAMGKKKISEMQKHREKFIDGAAKNGVSKKVAENLFDQMVKFAEY 774
|
|
| dnaE |
PRK07135 |
DNA polymerase III DnaE; Validated |
5-1045 |
0e+00 |
|
DNA polymerase III DnaE; Validated
Pssm-ID: 235944 [Multi-domain] Cd Length: 973 Bit Score: 592.05 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 5 FVHLRLHTEYSLVDGLVRIKPLVKALAGMGMPAVAVTDQNNMCSLVKFYKTSMGAGIKPICGADLWLSNKdpdnplsRIS 84
Cdd:PRK07135 3 LINLHTNTEYSFLSSTIKLDSLIKYAKENNLKTLVLTDHNNMFGVPKFYKLCKKNNIKPIIGLDLEVENF-------RFI 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 85 LLVMNAVGYRNLTELISRgfidgQRNGQIIierEWVAEAAEGLIMLSAAKEGeigmaLIAGDLEVAEtlarewmavFPER 164
Cdd:PRK07135 76 LLAKNYSGYKLLNELSSK-----KSKNKEI---ELNDLDSDNIIIIDHPKNG-----FYAKNKEQLE---------LKNY 133
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 165 FYLEvqrtNRPNDEEQLHAAValadkigaplvatndVRFIKQEDFEAHETRVCIGEGRALDdprrsKNYSDQQYLKSAEE 244
Cdd:PRK07135 134 YINS----NDPKIENAVYVQE---------------RKLLFAEDNEYLKILNKIGNNKEEN-----SNFKFFDFEKWFED 189
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 245 MAELFsdlpeaLENTVEIAKRCNIEVKLGKHFLPDYPIPDGMTIDEYFRKVsFDGLEERLSVLLPKDTTedyeakrqvYV 324
Cdd:PRK07135 190 IDEKI------LKRTNYLVENINIEFPKKEFNLPDFDNNLGLESDLFLKKI-LKESVINKKAELKYYPN---------VK 253
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 325 DRLNFELDIIIQMGFPGYFLIVMDFIQWAKSNGVPVGPGRGSGAGSLVAYVQKITDLDPLEYDLLFERFLNPERVSMPDF 404
Cdd:PRK07135 254 ERINYEYSVIKKLKFSNYFLIIWDFIKWARKNKISIGPGRGSASGSLVSYLLNITSVNPLKYDLLFERFLNPDRITMPDI 333
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 405 DVDFCMDGRDRVIDYVAEKYGRNAVSQIITFGSMAAKAVVRDVARVQGKSYGLADRLSKMIPFevGMTLEKAYEQEEILR 484
Cdd:PRK07135 334 DIDIQDDRRDEVIDYIFEKYGYEHCATISTFQTLGAKSAIRDVGRMLGIPESDVNAISKLIPN--NQSLEEAYDKNKSFF 411
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 485 DFI--KVDEEAAEIWEMARKLEGVVRNVGKHAGGVVIAPTKLTDFSPIYCDEEgGGLVTQFDKDDVEAAGLVKFDFLGLR 562
Cdd:PRK07135 412 RELisKGDPIYKKLYKIAKKLEGLPRQSGTHAAGIIISNKPITNYVPTFESKD-NYNQVQYSMEFLEDFGLLKIDLLGLK 490
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 563 TLTIIDWALKTINRDraKVGEEPLDIAFIPLDDKPTYSLLQKAETTAVFQLESRGMKELIKKLKPDCLEDLIALVALFRP 642
Cdd:PRK07135 491 NLTIIKNIEEKINKE--LLFDHLINFNDLPIIDKKTNNLLSNGKTEGIFQLESPGMKSTIKKVGIDSFEDIVAIISLYRP 568
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 643 GPLQsgMVDDFINRKHGRAELAYPHPDYqydglQPVLAPTYGIILYQEQVMQIAQVMAGYTLGGADMLRRAMGKKKPEEM 722
Cdd:PRK07135 569 GPIQ--YIPIYAKNKKNPKNIEKIHPEY-----DEIVAPTYGIIIYQEQIMQIAQKVAGFSFAQADLLRRAISKKDETKL 641
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 723 AKQRGGFIEGCASNNIDADLAGNIFDLVEKFAGYGFNKSHSAAYGLVSYQTAWLKAHYPAPFMAAVLSADMHNTDKVVTL 802
Cdd:PRK07135 642 DKIKDKFIEGGIKNGYSKKVLEKIYSLIEKFADYGFNKSHAVAYATLAYKMAYYKANYPLVFYSALISNSNGSQENIKKY 721
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 803 IEEVRIMKLRLDAPDVNTSEFKfTVNDEGRIVYGLGAIKGVGEGPVEAITEAR-EAGPFKDLFDFCARVDLKRINKRTLD 881
Cdd:PRK07135 722 VKEAKNNGIKVYSPDINFSTEN-AVFDNGKIFLPLIMIKGLGSVAIKKIIDERnKNGKYKNFFDFILRLKFIGISKSIIE 800
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 882 GLIRSGALDRLGphffdepkayqaNIDQnravLLAAMEEAIKAAEQTARthdsghaDLFGGVFVDEDADVYA--NHRKAK 959
Cdd:PRK07135 801 KLIKANTLRSFG------------NQDT----LLNNLELAKNYAETILS-------KVAKNLYDDYKNFGLDleFILEEI 857
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 960 ELTLKERLKGEKDTLGLYLTGHPIDEYEGEirrfaRQRIIDLKPARDTQTVAGMIIALRVMKNKKGDKMgfITLDDRSGR 1039
Cdd:PRK07135 858 ERDLEEESKNEIEYLGMSFNAFDTNKLEKN-----QIRLKDLRINTEYRLAIEVKNVKRLRKANKEYKK--VILSDDSVE 930
|
....*.
gi 1238823117 1040 IEASLF 1045
Cdd:PRK07135 931 ITIFVN 936
|
|
| dnaE2 |
PRK05672 |
error-prone DNA polymerase; Validated |
5-1011 |
0e+00 |
|
error-prone DNA polymerase; Validated
Pssm-ID: 235553 [Multi-domain] Cd Length: 1046 Bit Score: 590.29 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 5 FVHLRLHTEYSLVDGLVRIKPLVKALAGMGMPAVAVTDQNNMCSLVKFYKTSMGAGIKPICGADLWLSNkDPDNPLSRIS 84
Cdd:PRK05672 5 YAELHCHSNFSFLDGASHPEELVERAARLGLRALAITDECGLAGVVRAAEAAKELGLRLVIGAELSLGP-DPDPGGPHLL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 85 LLVMNAVGYRNLTELISRGFIDGQRnGQIIIEREWVAEAAEG--LIMLSAAKEGEIGMALIAGDLEVAETLAREWMAVFP 162
Cdd:PRK05672 84 VLARDREGYGRLSRLITRARLRAGK-GEYRLDLDDLAEPAGGhwAILTGCRKGFVILALPYGGDAAALAALAALLDAFFA 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 163 ERFYLEVQRTNRPNDEEQLHAAVALADKIGAPLVATNDVRFIKQEDFEAHETRVCIGEGRALDDPRRSKNYSDQQYLKSA 242
Cdd:PRK05672 163 DRVWLELTLHGRPDDDRRNARLAALAARAGVPLVATGDVHMHHRSRRRLQDAMTAIRARRSLAEAGGWLAPNGERHLRSG 242
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 243 EEMAELFSDLPEALENTVEIAKRCNIEVKLGKHFLPDYPIPDGMTIDEYFRKVSFDGLEERLsvllPKDTTEdyEAKRQv 322
Cdd:PRK05672 243 AEMARLFPDYPEALAETVELAERCAFDLDLLAYEYPDEPVPAGHTPASWLRQLTEAGAARRY----GPGIPP--KARAQ- 315
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 323 yvdrLNFELDIIIQMGFPGYFLIVMDFIQWAKSNGVpVGPGRGSGAGSLVAYVQKITDLDPLEYDLLFERFLNPERVSMP 402
Cdd:PRK05672 316 ----IEHELALIAELGYEGYFLTVHDIVRFARSQGI-LCQGRGSAANSAVCYALGITEVDPVQSGLLFERFLSPERDEPP 390
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 403 DFDVDFCMDGRDRVIDYVAEKYGRNAVSQIITFGSMAAKAVVRDVARVQGKSYGLADRLSKMIPFEVGMTLEKAYEQEEI 482
Cdd:PRK05672 391 DIDVDFEHDRREEVIQYVYRRYGRDRAAQVANVITYRPRSAVRDVAKALGLSPGQVDAWAKQVSRWSGSADDLQRLRQAG 470
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 483 LRDFIKVDEEAAeiwEMARKLEGVVRNVGKHAGGVVIAPTKLTDFSPIYCDEEGGGLVTQFDKDDVEAAGLVKFDFLGLR 562
Cdd:PRK05672 471 LDPESPIPRRVV---ELAAQLIGFPRHLSQHSGGFVICDRPLARLVPVENAAMEGRSVIQWDKDDCAAVGLVKVDVLALG 547
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 563 TLTIIDWALKTINRDRAKvgeePLDIAFIPLDDKPTYSLLQKAETTAVFQLESRGMKELIKKLKPDCLEDLIALVALFRP 642
Cdd:PRK05672 548 MLSALHRAFDLIAEHRGR----RLTLASIPLDDPAVYDMLCRADSVGVFQVESRAQMAMLPRLRPRTFYDLVVEVAIVRP 623
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 643 GPLQSGMVDDFINRKHGRAELAYPHPDyqydgLQPVLAPTYGIILYQEQVMQIAQVMAGYTLGGADMLRRAMG-KKKPEE 721
Cdd:PRK05672 624 GPIQGGMVHPYLRRRNGQEPVTYPHPE-----LEKVLERTLGVPLFQEQVMQIAIDAAGFTPGEADQLRRAMAaWRRKGR 698
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 722 MAKQRGGFIEGCASNNIDADLAGNIFDLVEKFAGYGFNKSHSAAYGLVSYQTAWLKAHYPAPFMAAVL-SADM--HNTDk 798
Cdd:PRK05672 699 LERLRERLYDGMLARGYTGEFADRIFEQIKGFGEYGFPESHAASFAKLVYASSWLKCHHPAAFCAALLnSQPMgfYSPQ- 777
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 799 vvTLIEEVRIMKLRLDAPDVNTSEFKFTV----NDEGRIVYGLGAIKGVGEGPVEAITEAREAGPFKDLFDFCARVDLkr 874
Cdd:PRK05672 778 --QLVQDARRHGVEVLPVDVNASGWDATLeplpDGGPAVRLGLRLVRGLGEEAAERIVAARARGPFTSVEDLARRAGL-- 853
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 875 iNKRTLDGLIRSGALDRLGPHffdepkayqanidqNRAVLLAAmeeaikAAEQTARthdsghADLFGGVFVDEDAdvyan 954
Cdd:PRK05672 854 -DRRQLEALADAGALRSLGGD--------------RRQALWAA------GAAATER------LDLLPGAPASEAA----- 901
|
970 980 990 1000 1010
....*....|....*....|....*....|....*....|....*....|....*...
gi 1238823117 955 hRKAKELTLKERLKGEKDTLGLYLTGHPIdEYegeIR-RFARQRIIdlkPARDTQTVA 1011
Cdd:PRK05672 902 -PALPGMSEGELVAADYWTTGLSLDSHPL-AL---LRpRLDARGVV---SAAELLDVE 951
|
|
| dnaE |
PRK07279 |
DNA polymerase III DnaE; Reviewed |
5-1072 |
5.89e-177 |
|
DNA polymerase III DnaE; Reviewed
Pssm-ID: 180917 [Multi-domain] Cd Length: 1034 Bit Score: 548.09 E-value: 5.89e-177
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 5 FVHLRLHTEYSLVDGLVRIKPLVKALAGMGMPAVAVTDQNNMCSLVKFYKTSMGAGIKPICGADLWLSNKDPDNPLSris 84
Cdd:PRK07279 2 FAQLDTKTVYSFMDSLIDLEKYVERAKELGYQTIGIMDKDNLYGAYHFIEGAQKNGLQPILGLELNIFVEEQEVTLR--- 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 85 LLVMNAVGYRNLTElISRGFIDGQRNgqiiierewvaeaaeglimLSAAKEGEIGMALIAGDLEVAETLArewmavFPER 164
Cdd:PRK07279 79 LIAKNTQGYKNLLK-ISTAKMSGKKQ-------------------FSDLSQYLEGIAVIVPYFDWSETLE------LPFD 132
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 165 FYLEVqrtnrpnDEEQLHAavaladKIGAPLVATNDVRFIKQEDFEAHETRVCIGEGRALDD-PRRSKNysdqQYLKSAE 243
Cdd:PRK07279 133 YYIGV-------DQETPGS------DFKRPILPLRTVRYFESADRETLQMLHAIRDNLSLREvPLVSSD----QELISCQ 195
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 244 EMAELFSD-LPEALEN----TVEIAKRCNIEVKLgKHFLPDYPIPdgmtidEYFRKVSFDGLEERLsvlLPKDttedyea 318
Cdd:PRK07279 196 SLETLFQErFPQALDNleklVSGISYDFDTDLKL-PRFNRDRPAV------EELRELAELGLKEKG---LWSS------- 258
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 319 krqVYVDRLNFELDIIIQMGFPGYFLIVMDFIQWAKSNGVPVGPGRGSGAGSLVAYVQKITDLDPLEYDLLFERFLNPER 398
Cdd:PRK07279 259 ---PYQERLDKELSVIHDMGFDDYFLIVWDLLRFGRSQGYYMGMGRGSAAGSLVAYALDITGIDPVKHNLLFERFLNKER 335
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 399 VSMPDFDVDFCMDGRDRVIDYVAEKYGRNAVSQIITFGSMAAKAVVRDVarvqGKSYGLAD----RLSKMIPFevGMTLE 474
Cdd:PRK07279 336 YSMPDIDIDLPDIYRSEFLRYVRNRYGSDHSAQIVTFSTFGAKQAIRDV----FKRFGVPEyelsNLTKKISF--RDSLA 409
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 475 KAYEQEEILRDFIKVDEEAAEIWEMARKLEGVVRNVGKHAGGVVIAPTKLTDFSPIYCDEEGggLVTQFDKDDVEAAGLV 554
Cdd:PRK07279 410 SVYEKNISFRQIINSKLEYQKAFEIAKRIEGNPRQTSIHAAGVVMSDDDLTNHIPLKYGDDM--MITQYDAHAVEANGLL 487
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 555 KFDFLGLRTLTIIdwalktiNRDRAKVGEE---PLDIAFIPLDDKPTYSLLQKAETTAVFQLESRGMKELIKKLKPDCLE 631
Cdd:PRK07279 488 KMDFLGLRNLTFV-------QKMQEKVAKDygiHIDIEAIDLEDKETLALFAAGDTKGIFQFEQPGAINLLKRIKPVCFE 560
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 632 DLIALVALFRPGPlqSGMVDDFINRKHGRAELayphpDYQYDGLQPVLAPTYGIILYQEQVMQIAQVMAGYTLGGADMLR 711
Cdd:PRK07279 561 DIVATTSLNRPGA--SDYTDNFVKRRHGQEKV-----DLIDPVIAPILEPTYGIMLYQEQVMQIAQVFAGFSLGKADLLR 633
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 712 RAMGKKKPEEMAKQRGGFIEGCASNNIDADLAGNIFDLVEKFAGYGFNKSHSAAYGLVSYQTAWLKAHYPAPFMAAVL-- 789
Cdd:PRK07279 634 RAMSKKNASEMQKMEEDFLQGALELGHSEEKARELFDRMEKFAGYGFNRSHAFAYSALAFQLAYFKAHYPAVFYDIMLny 713
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 790 -SADMhntdkvvtlIEEVRIMKLRLDAPDVNTSEFKFTVNDeGRIVYGLGAIKGVGEGPVEAITEAReagPFKDLFDFCA 868
Cdd:PRK07279 714 sSSDY---------ITDALEFGFEVAKLSINTIPYHDKIEN-KKIYLGLKNIKGLPRDLAYWIIENR---PFSSIEDFLT 780
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 869 RVDLKRINKRTLDGLIRSGALDRLgphffdepkayqaniDQNRAVLLAAMEeaikaaeqtarthdsghaDLFggVFVDE- 947
Cdd:PRK07279 781 RLPENYQKKEFLEPLIKIGLFDSF---------------EKNRQKIINNLD------------------NLF--VFVNEl 825
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 948 ---DADVYANHRKAKELTLKERLKGEKDTLGLYLTGHPIDEyegeirrFARQRIIDLKPARDTQ-----TVAGMIIALRV 1019
Cdd:PRK07279 826 gslFADSSYSWVEAEDYSETEKYSLEQELLGVGVSKHPLQA-------IAEKSSRPFTPISQLVknseaTILVQIQSIRV 898
|
1050 1060 1070 1080 1090
....*....|....*....|....*....|....*....|....*....|....
gi 1238823117 1020 MKNK-KGDKMGFITLDDRSGRIEASLFADAFHSAQSLLQTDAMVVVEGEVSNDD 1072
Cdd:PRK07279 899 IRTKtKGQQMAFLSVTDTKKKLDVTLFPETYRQYKDELKEGKFYYLKGKIQERD 952
|
|
| dnaE |
PRK05898 |
DNA polymerase III subunit alpha; |
5-1035 |
9.91e-168 |
|
DNA polymerase III subunit alpha;
Pssm-ID: 135648 [Multi-domain] Cd Length: 971 Bit Score: 522.09 E-value: 9.91e-168
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 5 FVHLRLHTEYSLVDGLVRIKPLVKALAGMGMPAVAVTDQNNMCSLVKFYKTSMGAGIKPICGADLwlsNKDPDNplSRIS 84
Cdd:PRK05898 2 FINLNTHSHYSLLSSTLSIDDIIKFALDNNQPYVCLTDLNNLYGCIEFYDKAKAHNLIPIIGLEI---EYQSTN--ATLV 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 85 LLVMNAVGYRNLTELISrgFIdgQRNGQIIIEREWvaeaaEGLIMLsaAKEGEIgmaliagdlevaetlarewmaVFPER 164
Cdd:PRK05898 77 LYAKNYNGYLNLIKISS--FI--MTNKEFEIQDYL-----DDLFIV--CKKGTF---------------------VFKSP 124
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 165 FYLEVQRTNRPNdeeqlhaAVALadkigaplvatNDVRFIKQEDFEAHETRVCIGEGRALDDPRRSKNYSDQQYLkSAEE 244
Cdd:PRK05898 125 NFYQTHNQNAPN-------AIAF-----------NSVFYANKNDKIVFNAMLAIKNDLKIDELKNCQDFDNNHFL-NDNE 185
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 245 MAELFSDLpeALENTVEIAKRCNIEVKLGKHFLPDYPIPDGMTIDEYFRKVSFDGLEERLSvllpkdttEDYEAKRQVYV 324
Cdd:PRK05898 186 AQSLFSPI--QLDNLNKVLNELKVEIHDLPINIIKYDKQNSIISSEILKQLCISGLNKRLN--------ANDGQVKKIYV 255
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 325 DRLNFELDIIIQMGFPGYFLIVMDFIQWAKSNGVPVGPGRGSGAGSLVAYVQKITDLDPLEYDLLFERFLNPERVSMPDF 404
Cdd:PRK05898 256 KRLKYELDIINEKQFDDYFLIVYDFINFAKSNGIIIGPGRGSAAGSLIAYLLHITDIDPIKYNLIFERFLNPTRKSMPDI 335
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 405 DVDFCMDGRDRVIDYVAEKYGRNAVSQIITFGSMAAKAVVRDVARVQGKSYGLADRLSKMIPFEVGMTLEKAYEQEEILR 484
Cdd:PRK05898 336 DTDIMDERRDEVVEYLFEKYGNDHVAHIITFQRIKAKMAIRDVGRILGIDLKVIDKICKNIKPDYEEDLDLAIKKNTILK 415
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 485 DFIKVDEeaaEIWEMARKLEGVVRNVGKHAGGVVIAPTKLTDFSPIYCDEEgGGLVTQFDKDDVEAAGLVKFDFLGLRTL 564
Cdd:PRK05898 416 EMYVLHK---ELFDLAKKIINAPRQIGTHAAGVVLSNSLLTNIIPIQLGIN-DRPLSQYSMEYLERFGLIKMDLLGLKNL 491
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 565 TIIDWALKTINRDRAKvgeePLDIAFIPLDDKPTYSLLQKAETTAVFQLESRGMKELIKKLKPDCLEDLIALVALFRPGP 644
Cdd:PRK05898 492 TIIDNVLKLIKENQNK----KIDLFNINLNDKNVFEDLAKGRTNGIFQLESPGMKKVLKKVKPQNIEDISIVSALFRPGP 567
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 645 LQSgmVDDFINRKHGRAELAYPHPDyqydgLQPVLAPTYGIILYQEQVMQIAQVMAGYTLGGADMLRRAMGKKKPEEMAK 724
Cdd:PRK05898 568 QQN--IKTFVERRFKREEFSYWNEA-----TKKILEPTHGIIVYQEQVINLVKTIANFDIATADNFRRAISKKDEKILIQ 640
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 725 QRGGFIEGCASNNIDADLAGNIFDLVEKFAGYGFNKSHSAAYGLVSYQTAWLKAHYPAPFMAAVLSADMHNTDKVVTLIE 804
Cdd:PRK05898 641 LKKDFIEGALKNNYKQPLVNQIFEYIFSFADYGFNHSHSLAYSYISYWMAYLKHYYPLEFLSILLSHTSASKDKLLSYLN 720
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 805 EVRIMKLRLDAPDVNTSEFKFTV-NDEGRIVYGLGAIKGVGEGPVEAITEAREAGPFKDLFDFCARVDLKRINKRTLDGL 883
Cdd:PRK05898 721 EAKEFNISIKKPDINYSSNSFVLdTQKQIIRFGFNTIKGFGDELLKKIKSALQNKTFSDFISYIDALKKNNVSLSNIEIL 800
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 884 IRSGALDRLGphffdepkayqanidQNRAVLLAAMEEAIKAaeqtarTHDSGHadLFGGVFVDEDAdvyanhrkAKELTL 963
Cdd:PRK05898 801 INVGTFDSFK---------------LSRLFLLNNLPEIFEK------TSLNGH--FFELNLVGLEY--------AKDMSV 849
|
970 980 990 1000 1010 1020 1030
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1238823117 964 KER-LKGEKDTLGLYLTGHPIDEYEGEI-RRFARQRIIDLKPARDTQTVAGMII---ALRVMKNKKGDKMGFITLDD 1035
Cdd:PRK05898 850 KERfLKKEIQYLGIDLNSLNYANYKNEIdYNELKYTIKDIKEIELKNTNYETNIfaqVYEIKQSKTKNGNLSFYLET 926
|
|
| PHP_PolIIIA_DnaE1 |
cd07433 |
Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III ... |
4-280 |
1.96e-163 |
|
Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; PolIIIAs that contain an N-terminal PHP domain have been classified into four basic groups based on genome composition, phylogenetic, and domain structural analysis: polC, dnaE1, dnaE2, and dnaE3. The PHP (also called histidinol phosphatase-2/HIS2) domain is associated with several types of DNA polymerases, such as PolIIIA and family X DNA polymerases, stand alone histidinol phosphate phosphatases (HisPPases), and a number of uncharacterized protein families. DNA polymerase III holoenzyme is one of the five eubacterial DNA polymerases that are responsible for the replication of the DNA duplex. PolIIIA core enzyme catalyzes the reaction for polymerizing both DNA strands. dnaE1 is the longest compared to dnaE2 and dnaE3. A unique motif was also identified in dnaE1 and dnaE3 genes.
Pssm-ID: 213988 [Multi-domain] Cd Length: 277 Bit Score: 485.44 E-value: 1.96e-163
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 4 SFVHLRLHTEYSLVDGLVRIKPLVKALAGMGMPAVAVTDQNNMCSLVKFYKTSMGAGIKPICGADLWLSNKDPDNPLSRI 83
Cdd:cd07433 1 SFVHLRVHSEYSLLDGAVRIKKLVKLAKEDGMPALAITDLSNLFGAVKFYKAASKAGIKPIIGADLNVANPDDADEPFRL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 84 SLLVMNAVGYRNLTELISRGFIDGQRNGQIIIEREWVAEAAEGLIMLSAAKEGEIGMALIAGDLEVAETLAREWMAVFPE 163
Cdd:cd07433 81 TLLAQNEQGYKNLTELISRAYLEGQRNGGPHIKLEWLAEYSEGLIALSGGRDGDIGQLLLEGNPDLAEALLQFLKKIFPD 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 164 RFYLEVQRTNRPNDEEQLHAAVALADKIGAPLVATNDVRFIKQEDFEAHETRVCIGEGRALDDPRRSKNYSDQQYLKSAE 243
Cdd:cd07433 161 RFYLELQRHGRPEEEAYEHALIDLAYELGLPLVATNDVRFLKPEDFEAHEARVCIAEGRTLDDPRRPRRYSPQQYFKSAE 240
|
250 260 270
....*....|....*....|....*....|....*..
gi 1238823117 244 EMAELFSDLPEALENTVEIAKRCNIEVKLGKHFLPDY 280
Cdd:cd07433 241 EMAELFADLPEAIENTVEIAKRCNVRIELGKPFLPDF 277
|
|
| DNA_pol3_alpha |
pfam07733 |
Bacterial DNA polymerase III alpha NTPase domain; |
290-560 |
2.26e-137 |
|
Bacterial DNA polymerase III alpha NTPase domain;
Pssm-ID: 400196 [Multi-domain] Cd Length: 259 Bit Score: 416.52 E-value: 2.26e-137
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 290 EYFRKVSFDGLEERLSVLLPKDttedyeakrqvYVDRLNFELDIIIQMGFPGYFLIVMDFIQWAKSNGVPVGPGRGSGAG 369
Cdd:pfam07733 1 EYLRKLVEEGLKERYGEGLPEE-----------YQERLEYELNVIIKMGFAGYFLIVWDLVKWAKDNGILVGPGRGSAAG 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 370 SLVAYVQKITDLDPLEYDLLFERFLNPERVSMPDFDVDFCMDGRDRVIDYVAEKYGRNAVSQIITFGSMAAKAVVRDVAR 449
Cdd:pfam07733 70 SLVAYLLGITEVDPLKHDLLFERFLNPERVSMPDIDIDFEDERREEVIDYVKEKYGRDRVAQIATFGTYAAKSAIRDVGR 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 450 VQGKSYGLADRLSKMIPFEVGMtLEKAYEQEEILRDFIKVDEEAAEIWEMARKLEGVVRNVGKHAGGVVIAPTKLTDFSP 529
Cdd:pfam07733 150 ALGLPYDEIDRLAKLIPFELGI-LEKALEEEPELKELIESDPEVKRLIELAKKLEGLPRHTGQHAGGVVISPDPLTDFVP 228
|
250 260 270
....*....|....*....|....*....|.
gi 1238823117 530 IYCDEEGGGLVTQFDKDDVEAAGLVKFDFLG 560
Cdd:pfam07733 229 LYKADDDDRPVTQFDKDDLEDLGLLKMDFLG 259
|
|
| PHP_PolIIIA_DnaE3 |
cd12113 |
Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III ... |
4-278 |
2.74e-97 |
|
Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; PolIIIAs that contain an N-terminal PHP domain have been classified into four basic groups based on genome composition, phylogenetic, and domain structural analysis: polC, dnaE1, dnaE2, and dnaE3. The PHP (also called histidinol phosphatase-2/HIS2) domain is associated with several types of DNA polymerases, such as PolIIIA and family X DNA polymerases, stand alone histidinol phosphate phosphatases (HisPPases), and a number of uncharacterized protein families. DNA polymerase III holoenzyme is one of the five eubacterial DNA polymerases that is responsible for the replication of the DNA duplex. The alpha subunit of DNA polymerase III core enzyme catalyzes the reaction for polymerizing both DNA strands. The PolIIIA PHP domain has four conserved sequence motifs and contains an invariant histidine that is involved in metal ion coordination, and like other PHP structures, the PolIIIA PHP exhibits a distorted (beta/alpha) 7 barrel and coordinates up to 3 metals. Initially, it was proposed that PHP region might be involved in pyrophosphate hydrolysis, but such an activity has not been found. It has been shown that the PHP of PolIIIA has a trinuclear metal complex and is capable of proofreading activity. Bacterial genome replication and DNA repair mechanisms is related to the GC content of its genomes. There is a correlation between GC content variations and the dimeric combinations of PolIIIA subunits. Eubacteria can be grouped into different GC variable groups: the full-spectrum or dnaE1 group, the high-GC or dnaE2-dnaE1 group, and the low GC or polC-dnaE3 group.
Pssm-ID: 213997 [Multi-domain] Cd Length: 283 Bit Score: 310.91 E-value: 2.74e-97
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 4 SFVHLRLHTEYSLVDGLVRIKPLVKALAGMGMPAVAVTDQNNMCSLVKFYKTSMGAGIKPICGADLWLSNKD-------- 75
Cdd:cd12113 1 DFVHLHVHTEYSLLDGAIRIKDLVKRAKELGMPALAITDHGNMFGAIEFYKAAKKAGIKPIIGCEVYVAPGSrfdkkdkk 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 76 PDNPLSRISLLVMNAVGYRNLTELISRGFIDGQ----RngqiiIEREWVAEAAEGLIMLSAAKEGEIGMALIAGDLEVAE 151
Cdd:cd12113 81 GDKRYYHLVLLAKNEEGYRNLMKLVSLAYLEGFyykpR-----IDKELLAKYSEGLIALSACLAGEIPQLLLNGDEEEAR 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 152 TLAREWMAVF-PERFYLEVQRTNRPNDEEQLHAAVALADKIGAPLVATNDVRFIKQEDFEAHETRVCIGEGRALDDPRRS 230
Cdd:cd12113 156 EAALEYRDIFgKDNFYLELQDHGLPEQKKVNEGLIELAKELGIPLVATNDVHYLNKEDAEAHDVLLCIQTGKTLDDPNRM 235
|
250 260 270 280
....*....|....*....|....*....|....*....|....*...
gi 1238823117 231 KNYSDQQYLKSAEEMAELFSDLPEALENTVEIAKRCNIEVKLGKHFLP 278
Cdd:cd12113 236 RFDTDEFYLKSPEEMRELFPDVPEALENTLEIAERCNVELDFGKLHLP 283
|
|
| DNA_pol3_finger |
pfam17657 |
Bacterial DNA polymerase III alpha subunit finger domain; |
563-737 |
4.44e-84 |
|
Bacterial DNA polymerase III alpha subunit finger domain;
Pssm-ID: 407553 [Multi-domain] Cd Length: 166 Bit Score: 270.17 E-value: 4.44e-84
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 563 TLTIIDWALKTINRDRAKvgeePLDIAFIPLDDKPTYSLLQKAETTAVFQLESRGMKELIKKLKPDCLEDLIALVALFRP 642
Cdd:pfam17657 1 TLTIIRDALDLIKENRGI----GIDLATIPLDDPKTYKLLSSGDTLGVFQFESRGMRQMLKRLKPDTFEDLVALSALYRP 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 643 GPLQSGMVDDFINRKHGRAELAYPHPDyqydgLQPVLAPTYGIILYQEQVMQIAQVMAGYTLGGADMLRRAMGKKKPEEM 722
Cdd:pfam17657 77 GPMQGGNVDDYIKRKHGKEKIEYPHPD-----LEPILKETYGVIVYQEQVMQIAQILAGFSLGEADLLRRAMGKKKPEEM 151
|
170
....*....|....*
gi 1238823117 723 AKQRGGFIEGCASNN 737
Cdd:pfam17657 152 EKLREKFIEGAKENG 166
|
|
| PRK07373 |
PRK07373 |
DNA polymerase III subunit alpha; Reviewed |
758-1160 |
4.13e-70 |
|
DNA polymerase III subunit alpha; Reviewed
Pssm-ID: 236003 [Multi-domain] Cd Length: 449 Bit Score: 242.28 E-value: 4.13e-70
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 758 FNKSHSAAYGLVSYQTAWLKAHYPAPFMAAVLSADMHNTDKVVTLIEEVRIMKLRLDAPDVNTSEFKFTVNDEgRIVYGL 837
Cdd:PRK07373 38 FNKSHSTAYAYVTYQTAYLKANYPVEYMAALLTANSGNQDKVQKYRENCQKMGIEVEPPDINRSGKDFTPVGE-KILFGL 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 838 GAIKGVGEGPVEAITEAR-EAGPFKDLFDFCARVDLKRINKRTLDGLIRSGALDRlgphffdepkayqanIDQNRAVLLA 916
Cdd:PRK07373 117 SAVRNLGEGAIESILKAReEGGEFKSLADFCDRVDLRVVNRRALETLIYCGAFDK---------------IEPNRQQLIN 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 917 AMEEAIKAAEQTARTHDSGHADLFGGVFVDEDADVYANHR-----KAK---ELTLKERLKGEKDTLGLYLTGHPIDEYEG 988
Cdd:PRK07373 182 DLELVIDWAQKRAKEKASGQGNLFDLLGGNTSNSSAANNAfeqapSAPpvaDFSLQEKLKLEKELLGFYVSEHPLKSIRR 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 989 EIRRFARQRIIDLKPARDTQTVAG--MIIALRVMKNKKGDKMGFITLDDRSGRIEASLFADAFHSAQSLLQTDAMVVVEG 1066
Cdd:PRK07373 262 PARLLSPINLSELEEQKEKTKVSAvvMLNEVKKIVTKKGDPMAFLQLEDLSGQSEAVVFPKSYERISELLQVDARLIIWG 341
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 1067 EVS-NDDfsgglrlRVKRVmsMEDARTnlAESLRLKI----HSDALKGDQLRWLGDLFKRH-----RGACPITMEYTRDD 1136
Cdd:PRK07373 342 KVDrRDD-------QVQLI--VEDAEP--IEEVRMVMvelsPQQAGNIVSQHRLKEILQEQagdknKAKVPVIAIIQSGG 410
|
410 420
....*....|....*....|....
gi 1238823117 1137 AKALLQFGENWRIDPADSLIQALR 1160
Cdd:PRK07373 411 NRQLVRLGQQYWVQDEHSAVQALQ 434
|
|
| PHP |
pfam02811 |
PHP domain; The PHP (Polymerase and Histidinol Phosphatase) domain is a putative ... |
7-172 |
5.88e-49 |
|
PHP domain; The PHP (Polymerase and Histidinol Phosphatase) domain is a putative phosphoesterase domain.
Pssm-ID: 460705 [Multi-domain] Cd Length: 171 Bit Score: 171.57 E-value: 5.88e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 7 HLRLHTEYSLVDGLVRIKPLVKALAGMGMPAVAVTDQNNMCSLVKFYKTSMGAGIKPICGADLWLSNKDPD------NPL 80
Cdd:pfam02811 1 HLHVHSEYSLLDGAARIEELVKRAKELGMPAIAITDHGNLFGAVEFYKAAKKAGIKPIIGCEVYVAPGSREetekllAKY 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 81 SRISLLVMNAVGYRNLTELISRGFIDGQRNGqiiIEREWVAEAAEGLIMLSAAKEGEIGMALIA-GDLEVAETLAREWMA 159
Cdd:pfam02811 81 FDLVLLAVHEVGYKNLIKLSSRAYLEGFKPR---IDKELLEEYFEGLIALSGCVLGHLDLILLApGDYEEAEELAEEYLE 157
|
170
....*....|....
gi 1238823117 160 VFPE-RFYLEVQRT 172
Cdd:pfam02811 158 IFGEdGFYLEINTH 171
|
|
| PHP_PolIIIA_DnaE2 |
cd07434 |
Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at ... |
26-267 |
9.93e-35 |
|
Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; PolIIIA DnaE2 plays a role in SOS mutagenesis/translesion synthesis and has dominant effects in determining GC variability in the bacterial genome. PolIIIAs that contain an N-terminal PHP domain have been classified into four basic groups based on genome composition, phylogenetic, and domain structural analysis: polC, dnaE1, dnaE2, and dnaE3. The PHP (also called histidinol phosphatase-2/HIS2) domain is associated with several types of DNA polymerases, such as PolIIIA and family X DNA polymerases, stand alone histidinol phosphate phosphatases (HisPPases), and a number of uncharacterized protein families. DNA polymerase III holoenzyme is one of the five eubacterial DNA polymerases that are responsible for the replication of the DNA duplex. PolIIIA core enzyme catalyzes the reaction for polymerizing both DNA strands. PolC PHP is located in a different location compared to dnaE1, 2, and 3. dnaE1 is the longest compared to dnaE2 and dnaE3. A unique motif was also identified in dnaE1 and dnaE3 genes. The PHP domain has four conserved sequence motifs and contains an invariant histidine that is involved in metal ion coordination. PHP domains found in DnaEs of thermophilic origin exhibit 3'-5' exonuclease activity.
Pssm-ID: 213989 [Multi-domain] Cd Length: 260 Bit Score: 133.74 E-value: 9.93e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 26 LVKALAGMGMPAVAVTDQNNMCSLVKFYKTSMGAGIKPICGADLWLsnkdpdNPLSRISLLVMNAVGYRNLTELISRGfi 105
Cdd:cd07434 22 LVARAAELGYRALAITDECSLAGVVRAHAAAKELGLKLIVGSELVL------ADGTRLVLLARDRAGYGRLCRLITLG-- 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 106 dgqRN----GQIIIEREWVAEAAEGLIMLSAAKEGEigmALIAGDLEVAETLARewmaVFPERFYLEVQRTNRPNDEEQL 181
Cdd:cd07434 94 ---RRraekGEYRLTLADLLAHAEGLLLILLPPDRL---PAAAALLAQLRWLAR----AFPGRLWLALELHLGGDDARRL 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 182 HAAVALADKIGAPLVATNDVRFIKQEDFEAHETRVCIGEGRALDD--PRRSKNysDQQYLKSAEEMAELFSDLPEALENT 259
Cdd:cd07434 164 ARLAALAAALGLPLVATGDVLMHSPSRRPLQDVLTAIRLGTTVAEagRRLAAN--AERHLRSPAELARLFLYPPEALAET 241
|
....*...
gi 1238823117 260 VEIAKRCN 267
Cdd:cd07434 242 LEIAARCT 249
|
|
| PHP_PolIIIA |
cd07431 |
Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; ... |
6-270 |
2.83e-34 |
|
Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; PolIIIAs that contain an N-terminal PHP domain have been classified into four basic groups based on genome composition, phylogenetic, and domain structural analysis: polC, dnaE1, dnaE2, and dnaE3. The PHP (also called histidinol phosphatase-2/HIS2) domain is associated with several types of DNA polymerases, such as PolIIIA and family X DNA polymerases, stand alone histidinol phosphate phosphatases (HisPPases), and a number of uncharacterized protein families. DNA polymerase III holoenzyme is one of the five eubacterial DNA polymerases that is responsible for the replication of the DNA duplex. The alpha subunit of DNA polymerase III core enzyme catalyzes the reaction for polymerizing both DNA strands. The PolIIIA PHP domain has four conserved sequence motifs and contains an invariant histidine that is involved in metal ion coordination, and like other PHP structures, exhibits a distorted (beta/alpha) 7 barrel and coordinates up to 3 metals. Initially, it was proposed that PHP region might be involved in pyrophosphate hydrolysis, but such activity has not been found. It has been shown that the PHP domain of PolIIIA has a trinuclear metal complex and is capable of proofreading activity.
Pssm-ID: 213986 [Multi-domain] Cd Length: 179 Bit Score: 129.63 E-value: 2.83e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 6 VHLRLHTEYSLVDGLVRIKPLVKALAGMGMPAVAVTDQNNMCSLVKFYKTSMGAGIKPICGADLWLsnkDPDNPLSRISL 85
Cdd:cd07431 1 AHLHVHSSYSLLDSAIRPEDLVARAKELGYSALALTDRNVLYGAVRFYKACKKAGIKPIIGLELTV---EGDGEPYPLLL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 86 LVMNAVGYRNLTELISRGFIDGQRNGQIIIEREWVAEAAEGLImlsaakegeigmALIAGdlevaetlarewmavfperf 165
Cdd:cd07431 78 LAKNNEGYQNLLRLSTAAMLGEEKDGVPYLDLEELAEAASGLL------------VVLLG-------------------- 125
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 166 ylevqrtnrpndeeqlHAAVALADKIGAPLVATNDVRFIKQEDFEAHETRVCigegralddprrsknysdqqylksaeem 245
Cdd:cd07431 126 ----------------PLLLLLAAEQGLPLVATNDVHYLNPEDAFAADVLTA---------------------------- 161
|
250 260
....*....|....*....|....*
gi 1238823117 246 aelfsdlPEALENTVEIAKRCNIEV 270
Cdd:cd07431 162 -------FLAVANTVRIAKECAVEL 179
|
|
| polC |
PRK00448 |
DNA polymerase III PolC; Validated |
83-892 |
3.65e-31 |
|
DNA polymerase III PolC; Validated
Pssm-ID: 234767 [Multi-domain] Cd Length: 1437 Bit Score: 133.42 E-value: 3.65e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 83 ISLLVMNAVGYRNLTELISRG----FIDGQRngqiiIEREWVAEAAEGLIMLSAAKEGEIGMALIAGDLEVAETLARewm 158
Cdd:PRK00448 613 ATILVKNQVGLKNLFKLVSLSntkyFYRVPR-----IPRSLLDKYREGLLIGSACEEGEVFDAVLQKGDEELEEIAK--- 684
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 159 avfperFY--LEVQ--RTNRP-------NDEEQLHAA----VALADKIGAPLVATNDVRFIKQEDFEAHETRVCigeGRA 223
Cdd:PRK00448 685 ------FYdyIEIQppANYQHlierelvKDEEELKEIiknlIELGKKLNKPVVATGDVHYLDPEDKIYRKILVA---SQG 755
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 224 LDDPRRSKNYSDqQYLKSAEEMAELFSDLPEAL------ENTVEIAKRCNiEVKlgkhflpdyPIPDGMtideYFRKvsF 297
Cdd:PRK00448 756 GGNPLNRHPLPE-LHFRTTDEMLDEFAFLGEELakeivvENTNKIADLIE-EIE---------PIKDKL----YTPK--I 818
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 298 DGLEERLsvllpKDTTedYEAKRQVY--------VDRLNFELDIIIQMGFPGYFLIVMDFIQWAKSNGVPVGPgRGSGAG 369
Cdd:PRK00448 819 EGAEEEI-----RELT--YKKAHEIYgeplpeivEKRIEKELNSIIGNGFAVIYLISQKLVKKSLEDGYLVGS-RGSVGS 890
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 370 SLVAYVQKITDLDPLE----------------------YDLL-------------------FERFLNPERVSMPDFDVDF 408
Cdd:PRK00448 891 SFVATMIGITEVNPLPphyvcpnckysefftdgsvgsgFDLPdkdcpkcgtklkkdghdipFETFLGFKGDKVPDIDLNF 970
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 409 CMDGRDRVIDYVAEKYGRNAVSQIITFGSMAAKavvrdvarvqgKSYGLAdrlskmipfevgmtleKAYEQE--EILRDf 486
Cdd:PRK00448 971 SGEYQPVAHNYTKVLFGEDHVFRAGTIGTVAEK-----------TAYGYV----------------KKYEEDtgKFYRN- 1022
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 487 ikvdeeaAEIWEMARKLEGVVRNVGKHAGGVVIAPTKLT--DFSPIycdeeggglvtQFDKDDVEAA------------- 551
Cdd:PRK00448 1023 -------AEIDRLAQGCTGVKRTTGQHPGGIIVVPKYMDiyDFTPI-----------QYPADDVNSEwktthfdfhsihd 1084
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 552 GLVKFDFLG---------LRTLTIIDwalktinrdrakvgeePLDiafIPLDDKPTYSLLQKAETTAVF--QLES----- 615
Cdd:PRK00448 1085 NLLKLDILGhddptmirmLQDLTGID----------------PKT---IPMDDPKVMKLFSSTEALGVTpeQIGCetgtl 1145
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 616 ----------RGMkelIKKLKPDCLEDLIALvalfrpgplqSGM----------VDDFInrKHGRAELA----------- 664
Cdd:PRK00448 1146 gipefgtkfvRQM---LEETKPKTFAELVQI----------SGLshgtdvwlgnAQELI--KEGIATLSdvigcrddimv 1210
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 665 YphpdYQYDGLQPVLAPTygiILyqEQVmqiaqvmagytlggadmlRRamGKKKPEEMAK--QRGG----FIEGCasNNI 738
Cdd:PRK00448 1211 Y----LIHKGLEPKLAFK---IM--ESV------------------RK--GKGLTEEEEElmKENNvpdwYIESC--KKI 1259
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 739 dadlagnifdlvekfaGYGFNKSHSAAYGLVSYQTAWLKAHYPAPFMAAVLS--AD-------MHNTDKVVTLIEEVRIM 809
Cdd:PRK00448 1260 ----------------KYMFPKAHAAAYVLMAWRIAYFKVHYPLAYYAAYFSvrADdfdletmSKGKEAIKAKMKEIKSK 1323
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 810 KLRLDA------------------------PDVNTSE-FKFTVNDEGRIVyGLGAIKGVGEGPVEAITEAREAGPFKDLF 864
Cdd:PRK00448 1324 GNDASNkekdlltvleialemlergfkfqkVDLYKSDaTEFIIEGDSLIP-PFNALPGLGENVAKSIVEAREEGEFLSKE 1402
|
970 980
....*....|....*....|....*...
gi 1238823117 865 DFCARvdlKRINKRTLDGLIRSGALDRL 892
Cdd:PRK00448 1403 DLRKR---TKVSKTLIEKLDELGVLDDL 1427
|
|
| HHH_6 |
pfam14579 |
Helix-hairpin-helix motif; The HHH domain is a short DNA-binding domain. |
816-895 |
3.77e-30 |
|
Helix-hairpin-helix motif; The HHH domain is a short DNA-binding domain.
Pssm-ID: 434050 [Multi-domain] Cd Length: 88 Bit Score: 114.49 E-value: 3.77e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 816 PDVNTSEFKFTVNDeGRIVYGLGAIKGVGEGPVEAITEAREAGPFKDLFDFCARVDLKrINKRTLDGLIRSGALDRLGPH 895
Cdd:pfam14579 7 PDINRSDWDFTVEG-GGIRLGLGAIKGLGEAAAERIVEERENGPFKSLEDFARRVDLK-LNKRVLEALIKAGAFDSLGGN 84
|
|
| PHP_PolIIIA_POLC |
cd07435 |
Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at ... |
6-263 |
5.52e-27 |
|
Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; DNA polymerase III alphas (PolIIIAs) that contain a PHP domain have been classified into four basic groups based on phylogenetic and domain structural analyses: polC, dnaE1, dnaE2, and dnaE3. The PolC group is distinct from the other three and is clustered together. The PHP (also called histidinol phosphatase-2/HIS2) domain is associated with several types of DNA polymerases, such as PolIIIA and family X DNA polymerases, stand alone histidinol phosphate phosphatases (HisPPases), and a number of uncharacterized protein families. DNA polymerase III holoenzyme is one of the five eubacterial DNA polymerases that are responsible for the replication of the DNA duplex. The alpha subunit of DNA polymerase III core enzyme catalyzes the reaction for polymerizing both DNA strands. PolC PHP is located in different location compare to dnaE1, 2, and 3. The PHP domain has four conserved sequence motifs and and contains an invariant histidine that is involved in metal ion coordination.The PHP domain of PolC is structurally homologous to other members of the PHP family that have a distorted (beta/alpha)7 barrel fold with a trinuclear metal site on the C-terminal side of the barrel. PHP domains found in dnaEs of thermophilic origin exhibit 3'-5' exonuclease activity. In contrast, PolC PHP lacks detectable nuclease activity.
Pssm-ID: 213990 [Multi-domain] Cd Length: 268 Bit Score: 111.80 E-value: 5.52e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 6 VHLRLHTEYSLVDGLVRIKPLVKALAGMGMPAVAVTDQNNMCSLVKFYKTSMGAGIKPICGADLWLSNKdpdnplSRISL 85
Cdd:cd07435 2 VELHAHTKMSAMDGVTSVKELVKRAAEWGHKAIAITDHGVVQAFPEAYEAAKKNGIKVIYGVEAYLVDP------YHITI 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 86 LVMNAVGYRNLTELISRGFIDGqRNGQIIIEREWVAEAAEGLIMLSAAKEGEIGMALIAGDLEVAetlAREWMavfpeRF 165
Cdd:cd07435 76 LVKNQTGLKNLYKLVSLSHTKY-FYRVPRIPKSELEKYREGLLIGSACENGELFEAALNKKSDEE---LEEIA-----SF 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 166 Y--LEVQ---------RTNRPNDEEQLHAA----VALADKIGAPLVATNDVRFIKQEDfeaHETRVCIGEGRALDDPRRs 230
Cdd:cd07435 147 YdyIEIQpldnyqfliEKGLIKSEEELKEInkriIKLGKKLNKPVVATGDVHYLDPED---KIYREILLAGQGGGDGRA- 222
|
250 260 270
....*....|....*....|....*....|....*....
gi 1238823117 231 KNYSDqQYLKSAEEMAELFSDLPEAL------ENTVEIA 263
Cdd:cd07435 223 DEQPD-LYFRTTDEMLDEFSYLGEEKayevvvTNTNKIA 260
|
|
| DnaE_OBF |
cd04485 |
DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding ... |
1009-1094 |
1.55e-24 |
|
DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains two copies of this replicative polymerase, each of which copies a different DNA strand. This group also contains Bacillus subtilis DnaE. Replication in B. subtilis and Staphylococcus aureus requires two different type C polymerases, polC and DnaE, both of which are thought to be included in the DNA polymerase holoenzyme. At the B. subtilis replication fork, polC appears to be involved in leading strand synthesis and DnaE in lagging strand synthesis.
Pssm-ID: 239931 [Multi-domain] Cd Length: 84 Bit Score: 98.35 E-value: 1.55e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1238823117 1009 TVAGMIIALRVMKNKKGDKMGFITLDDRSGRIEASLFADAFHSAQSLLQTDAMVVVEGEVSNDDfsGGLRLRVKRVMSME 1088
Cdd:cd04485 1 TVAGLVTSVRRRRTKKGKRMAFVTLEDLTGSIEVVVFPETYEKYRDLLKEDALLLVEGKVERRD--GGLRLIAERIEDLE 78
|
....*.
gi 1238823117 1089 DARTNL 1094
Cdd:cd04485 79 DARERL 84
|
|
| POLIIIAc |
smart00481 |
DNA polymerase alpha chain like domain; DNA polymerase alpha chain like domain, incl. family ... |
7-71 |
2.67e-20 |
|
DNA polymerase alpha chain like domain; DNA polymerase alpha chain like domain, incl. family of hypothetical proteins
Pssm-ID: 197753 [Multi-domain] Cd Length: 67 Bit Score: 85.78 E-value: 2.67e-20
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1238823117 7 HLRLHTEYSLVDGLVRIKPLVKALAGMGMPAVAVTDQNNMCSLVKFYKTSMGAGIKPICGADLWL 71
Cdd:smart00481 1 DLHVHSDYSLLDGALSPEELVKRAKELGLKAIAITDHGNLFGAVEFYKAAKKAGIKPIIGLEANI 65
|
|
| tRNA_anti-codon |
pfam01336 |
OB-fold nucleic acid binding domain; This family contains OB-fold domains that bind to nucleic ... |
1009-1084 |
8.50e-11 |
|
OB-fold nucleic acid binding domain; This family contains OB-fold domains that bind to nucleic acids. The family includes the anti-codon binding domain of lysyl, aspartyl, and asparaginyl -tRNA synthetases (See pfam00152). Aminoacyl-tRNA synthetases catalyze the addition of an amino acid to the appropriate tRNA molecule EC:6.1.1.-. This family also includes part of RecG helicase involved in DNA repair. Replication factor A is a hetero-trimeric complex, that contains a subunit in this family. This domain is also found at the C-terminus of bacterial DNA polymerase III alpha chain.
Pssm-ID: 460164 [Multi-domain] Cd Length: 75 Bit Score: 58.79 E-value: 8.50e-11
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1238823117 1009 TVAGMIIALRvmknKKGDKMGFITLDDRSGRIEASLFADAFHSAQSLLQTDAMVVVEGEVSNDDFsGGLRLRVKRV 1084
Cdd:pfam01336 2 TVAGRVTSIR----RSGGKLLFLTLRDGTGSIQVVVFKEEAEKLAKKLKEGDVVRVTGKVKKRKG-GELELVVEEI 72
|
|
| PHP |
cd07309 |
Polymerase and Histidinol Phosphatase domain; The PHP (also called histidinol phosphatase-2 ... |
6-68 |
1.77e-06 |
|
Polymerase and Histidinol Phosphatase domain; The PHP (also called histidinol phosphatase-2/HIS2) domain is associated with several types of DNA polymerases, such as PolIIIA and family X DNA polymerases, stand alone histidinol phosphate phosphatases (HisPPases), and a number of uncharacterized protein families. The PHP domain has four conserved sequence motifs and contains an invariant histidine that is involved in metal ion coordination. PHP in polymerases has trinuclear zinc/magnesium dependent proofreading activity. It has also been shown that the PHP domain functions in DNA repair. The PHP structures have a distorted (beta/alpha)7 barrel fold with a trinuclear metal site on the C-terminal side of the barrel.
Pssm-ID: 213985 [Multi-domain] Cd Length: 88 Bit Score: 47.04 E-value: 1.77e-06
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1238823117 6 VHLRLHTEYSLVDgLVRIKPLVKALAGMGMPAVAVTDQNNMCSLVKF--------YKTSMGAGIKPICGAD 68
Cdd:cd07309 1 VDLHTHTVFSDGD-HAKLTELVDKAKELGPDALAITDHGNLRGLAEFntagk*nhIKAAEAAGIKIIIGSE 70
|
|
| |
