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Conserved domains on  [gi|1278971888|gb|ATW66971|]
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NADH dehydrogenase subunit 6 (mitochondrion) [Castor canadensis]

Protein Classification

NADH dehydrogenase subunit 6( domain architecture ID 10009569)

NADH dehydrogenase subunit 6 is the core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that functions in the transfer of electrons from NADH to the respiratory chain

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ND6 MTH00109
NADH dehydrogenase subunit 6; Provisional
 1-174 4.74e-82

NADH dehydrogenase subunit 6; Provisional


:

Pssm-ID: 214421  Cd Length: 175  Bit Score: 240.09  E-value: 4.74e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278971888   1 MTYSMYLLSIMFVLGFVGFSSKPSPIYGGLGLIVSGGVGCGLILSFGGSFLGLMVFLVYLGGMMVVFGYTTAMAIEDYPE 80
Cdd:MTH00109    2 MMYIVFILSVLFVLGFVGFSSKPSPIYGGLGLIVSGGVGCGIVLSFGGSFLGLMVFLIYLGGMLVVFGYTTAMATEEYPE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278971888  81 TWGSNVAIWSALVFGLFVELIFLALLVKNDEVDVLGGVYNTSDWVVYSGEGVECINKDVMGVAAVYSYGCWLMVLAGWSL 160
Cdd:MTH00109   82 TWVSNKVVLGALLLGLLMELLLVLYVLKDDEVEVVFNFNGLGDWVIYDTGGSGFFSEDAMGVAALYSYGTWLVVVTGWSL 161

                         170
                  ....*....|....
gi 1278971888 161 FVSIFIVLEITRGR 174
Cdd:MTH00109  162 FIGVFVIIEITRGN 175
 
Name Accession Description Interval E-value
ND6 MTH00109
NADH dehydrogenase subunit 6; Provisional
 1-174 4.74e-82

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214421  Cd Length: 175  Bit Score: 240.09  E-value: 4.74e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278971888   1 MTYSMYLLSIMFVLGFVGFSSKPSPIYGGLGLIVSGGVGCGLILSFGGSFLGLMVFLVYLGGMMVVFGYTTAMAIEDYPE 80
Cdd:MTH00109    2 MMYIVFILSVLFVLGFVGFSSKPSPIYGGLGLIVSGGVGCGIVLSFGGSFLGLMVFLIYLGGMLVVFGYTTAMATEEYPE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278971888  81 TWGSNVAIWSALVFGLFVELIFLALLVKNDEVDVLGGVYNTSDWVVYSGEGVECINKDVMGVAAVYSYGCWLMVLAGWSL 160
Cdd:MTH00109   82 TWVSNKVVLGALLLGLLMELLLVLYVLKDDEVEVVFNFNGLGDWVIYDTGGSGFFSEDAMGVAALYSYGTWLVVVTGWSL 161

                         170
                  ....*....|....
gi 1278971888 161 FVSIFIVLEITRGR 174
Cdd:MTH00109  162 FIGVFVIIEITRGN 175
Oxidored_q3 pfam00499
NADH-ubiquinone/plastoquinone oxidoreductase chain 6;
17-170 2.72e-13

NADH-ubiquinone/plastoquinone oxidoreductase chain 6;


Pssm-ID: 459832 [Multi-domain]  Cd Length: 141  Bit Score: 63.29  E-value: 2.72e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278971888  17 VGFSSKPSPIYGGLGLIVSGGVGCGLILSFGGSFLGLMVFLVYLGGMMVVFGYTTAM-AIEDYPETWGSNVAIWSALVFG 95
Cdd:pfam00499   1 LGVVTSRNPVHSALFLVLTFFGVAGLYLLLGAEFLAAVQVLVYVGAIMVLFLFVIMLlLAEEEPEKLRSGLPLAALLLGL 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1278971888  96 LFVELIFLALLVKNDEVDVLGGVYNTSdwvvysgegveciNKDVMGVAAVYSYGcWLMVLAGWSLFVSIFIVLEI 170
Cdd:pfam00499  81 LLLALLLLVLLSASLTPAAAAAAPDVG-------------NIEAIGELLFTDYL-LPFELASVLLLVALVGAIVL 141
NuoJ COG0839
NADH:ubiquinone oxidoreductase subunit 6 (chain J) [Energy production and conversion]; NADH: ...
 6-105 7.38e-04

NADH:ubiquinone oxidoreductase subunit 6 (chain J) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 6 (chain J) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440601 [Multi-domain]  Cd Length: 162  Bit Score: 38.17  E-value: 7.38e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278971888   6 YLLSIMFVLGFVGFSSKPSPIYGGLGLIVSGGVGCGLILSFGGSFLGLMVFLVYLGGMMVVFGYTTAM---AIEDYPETW 82
Cdd:COG0839     6 YIFAALAVASALGVVTSRNPVHAALYLVLTFLSVAGLYLLLGAEFLAAVQVIVYVGAVMVLFLFVVMLldlDKEELREGF 85

                          90       100
                  ....*....|....*....|...
gi 1278971888  83 GSNVAIWSALVFGLFVELIFLAL 105
Cdd:COG0839    86 RKYRPLAALVGLLLLAELAYVLL 108
 
Name Accession Description Interval E-value
ND6 MTH00109
NADH dehydrogenase subunit 6; Provisional
 1-174 4.74e-82

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214421  Cd Length: 175  Bit Score: 240.09  E-value: 4.74e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278971888   1 MTYSMYLLSIMFVLGFVGFSSKPSPIYGGLGLIVSGGVGCGLILSFGGSFLGLMVFLVYLGGMMVVFGYTTAMAIEDYPE 80
Cdd:MTH00109    2 MMYIVFILSVLFVLGFVGFSSKPSPIYGGLGLIVSGGVGCGIVLSFGGSFLGLMVFLIYLGGMLVVFGYTTAMATEEYPE 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278971888  81 TWGSNVAIWSALVFGLFVELIFLALLVKNDEVDVLGGVYNTSDWVVYSGEGVECINKDVMGVAAVYSYGCWLMVLAGWSL 160
Cdd:MTH00109   82 TWVSNKVVLGALLLGLLMELLLVLYVLKDDEVEVVFNFNGLGDWVIYDTGGSGFFSEDAMGVAALYSYGTWLVVVTGWSL 161

                         170
                  ....*....|....
gi 1278971888 161 FVSIFIVLEITRGR 174
Cdd:MTH00109  162 FIGVFVIIEITRGN 175
ND6 MTH00138
NADH dehydrogenase subunit 6; Provisional
 1-174 4.46e-41

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 177196  Cd Length: 173  Bit Score: 136.04  E-value: 4.46e-41
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278971888   1 MTYSMYLLSIMFVLGFVGFSSKPSPIYGGLGLIVSGGVGCGLILSFGGSFLGLMVFLVYLGGMMVVFGYTTAMAIEDYPE 80
Cdd:MTH00138    1 MTYLMSLFLLGLVLGLVAVASNPSPYFAALGLVVVAGVGCGVLVGHGGSFLSLVLFLIYLGGMLVVFAYSAALAAEPYPE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278971888  81 TWGSNVAIWSALVFGLFVELIFLALlvkndevdvLGGVYNTSDWVVYSGEGVECINKDVMGVAAVYSYGCWLMVLAGWSL 160
Cdd:MTH00138   81 SWGSWSVLGYVVGYLVGVVLAAGLF---------WGGWYEGSWVVVDELKEFSVLRGDVGGVALMYSSGGGMLVICAWVL 151

                         170
                  ....*....|....
gi 1278971888 161 FVSIFIVLEITRGR 174
Cdd:MTH00138  152 LLTLFVVLELTRGL 165
ND6 MTH00065
NADH dehydrogenase subunit 6; Provisional
 1-173 1.20e-33

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214415  Cd Length: 172  Bit Score: 116.87  E-value: 1.20e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278971888   1 MTYSMYLLSIMFVLGFVGFSSKPSPIYGGLGLIVSGGVGCGLILSFGGSFLGLMVFLVYLGGMMVVFGYTTAMAIEDYPE 80
Cdd:MTH00065    1 MMYLGFLGMLGLVVGLVAVASNPSPYFAALGLVLGAVCGCLVLVELGVSFLSLVLFLIYLGGMLVVFAYSAALAAEPYPE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278971888  81 TWGSNVAIWSALVFGLFVELIFLallvkndevdVLGGVYNTSDWVVYSGEGVECINKDVMGVAAVYSYGCWLMVLAGWSL 160
Cdd:MTH00065   81 AWGSWSVLVYVLFYLLLLIVGYI----------LFGCNFSLEFLFTNYDTEFSVVGYDWGGVGLMYSSGGWFLMISGWVL 150

                         170
                  ....*....|...
gi 1278971888 161 FVSIFIVLEITRG 173
Cdd:MTH00065  151 LLTLFVVLEVTRG 163
ND6 MTH00115
NADH dehydrogenase subunit 6; Provisional
 1-173 4.13e-27

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214424  Cd Length: 174  Bit Score: 100.21  E-value: 4.13e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278971888   1 MTYSMYLLSIMFVLGFVGFSSKPSPIYGGLGLIVSGGVGCGLILSFGGSFLGLMVFLVYLGGMMVVFGYTTAMAIEDYPE 80
Cdd:MTH00115    1 MMYFVFLLGVCFVLGVVGVASNPSPYYGVVSLVLASVFGCGVLVSLGGSFVSLVLFLVYLGGMLVVFAYSVSLAADPYPE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278971888  81 TWGSnvaiWSALVFGL-FVELIFLALLVKNDEVDVLGGVYNTSDWVvysgeGVECINKDVMGVAAVYSYGCWLMVLAGWS 159
Cdd:MTH00115   81 AWGD----WGVVGYVVgFVLVVVVVGVVVGGLWGMEGVGVVTVDSG-----GLFVVRLDFSGVSLFYSSGGGGLLVCGWG 151

                         170
                  ....*....|....
gi 1278971888 160 LFVSIFIVLEITRG 173
Cdd:MTH00115  152 LLLTLFVVLELVRG 165
ND6 MTH00214
NADH dehydrogenase subunit 6; Provisional
 1-174 7.88e-18

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214461  Cd Length: 168  Bit Score: 76.18  E-value: 7.88e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278971888   1 MTYSMYLLSIMFVLGFVGFSSKPSPIYGGLGLIVSGGVGCGLILSFGGSFLGLMVFLVYLGGMMVVFGYTTAMAIEDYPE 80
Cdd:MTH00214    1 MLYFVFLLMFGFLLGLMMVASSPSPYFGALGLVLLALLGCFLLLSHGNSFLGLILFLIYLGGMLVVFSYSAALAADPYPE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278971888  81 TWGSNVAIWSALVFGLFVELIFLALLVKNDEVDVLGGVYNtsdwvvysgegvecINKDVMGVAAVYSYGCWLMVLAGWSL 160
Cdd:MTH00214   81 SWGGWSVLLFFLFYLLGLGFVGFYFYGGWEMLSWMGVDEA--------------NNLDLSGVSDLYSRGFFLLLLGGVVL 146

                         170
                  ....*....|....
gi 1278971888 161 FVSIFIVLEITRGR 174
Cdd:MTH00214  147 FLVLFVVLELVRGL 160
Oxidored_q3 pfam00499
NADH-ubiquinone/plastoquinone oxidoreductase chain 6;
17-170 2.72e-13

NADH-ubiquinone/plastoquinone oxidoreductase chain 6;


Pssm-ID: 459832 [Multi-domain]  Cd Length: 141  Bit Score: 63.29  E-value: 2.72e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278971888  17 VGFSSKPSPIYGGLGLIVSGGVGCGLILSFGGSFLGLMVFLVYLGGMMVVFGYTTAM-AIEDYPETWGSNVAIWSALVFG 95
Cdd:pfam00499   1 LGVVTSRNPVHSALFLVLTFFGVAGLYLLLGAEFLAAVQVLVYVGAIMVLFLFVIMLlLAEEEPEKLRSGLPLAALLLGL 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1278971888  96 LFVELIFLALLVKNDEVDVLGGVYNTSdwvvysgegveciNKDVMGVAAVYSYGcWLMVLAGWSLFVSIFIVLEI 170
Cdd:pfam00499  81 LLLALLLLVLLSASLTPAAAAAAPDVG-------------NIEAIGELLFTDYL-LPFELASVLLLVALVGAIVL 141
ND6 MTH00045
NADH dehydrogenase subunit 6; Validated
 1-173 2.26e-12

NADH dehydrogenase subunit 6; Validated


Pssm-ID: 177120  Cd Length: 162  Bit Score: 61.46  E-value: 2.26e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278971888   1 MTYSMYLLSIMFVLGFVGFSSkpSPIYGGLGLIVSGGVGCGLILSFGGSFLGLMVFLVYLGGMMVVFGYTTAMAIEDYPE 80
Cdd:MTH00045    1 MVFYLFLILMLFGSTLVFYSL--SPYYSALGLVLVSLSGCLLLSLLGLSFLALLLLLIYMGGMLVVFVYSSALSAERYPS 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278971888  81 TWGSNVAIWSALVFGLFVELIFlallvkndevdvlggvYNTSDWVVYSGEGVEciNKDVMGVAAVYSYGCWLMVLAGWSL 160
Cdd:MTH00045   79 VSNLGEVLVLSLLLSLWVFISF----------------DNFLELSNNNWSLVS--LSDLVGSSELYNSGGLYLLLGGFIL 140

                         170
                  ....*....|...
gi 1278971888 161 FVSIFIVLEITRG 173
Cdd:MTH00045  141 LVALVVALVISFG 153
ND6 MTH00152
NADH dehydrogenase subunit 6; Provisional
 4-133 4.36e-04

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214437  Cd Length: 163  Bit Score: 38.71  E-value: 4.36e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278971888   4 SMYLLSIMFVLGFVGFSSKPSPIYGGLGLIVSGGVGCGLILSFGGSFLGLMVFLVYLGGMMVVFGYtTAMAIEDYPETWG 83
Cdd:MTH00152    2 SLMILLSVCFSLFLLLPLSKQPLSLGLVLLLLSLFVCVEIGLTLSSWYGYLLFLVYVGGLLVMFAY-VVSLSPNPLFGSN 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1278971888  84 SNVAIWSALVFGLFVELIFLALLVKNDEVDVLGGVYNTSDWVVYSGEGVE 133
Cdd:MTH00152   81 FKFVFFSLTLFGFLGLFFFFLYLYSSGGLSLSSLFDGSSGSLSFGGGLYS 130
NuoJ COG0839
NADH:ubiquinone oxidoreductase subunit 6 (chain J) [Energy production and conversion]; NADH: ...
 6-105 7.38e-04

NADH:ubiquinone oxidoreductase subunit 6 (chain J) [Energy production and conversion]; NADH:ubiquinone oxidoreductase subunit 6 (chain J) is part of the Pathway/BioSystem: NADH dehydrogenase


Pssm-ID: 440601 [Multi-domain]  Cd Length: 162  Bit Score: 38.17  E-value: 7.38e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1278971888   6 YLLSIMFVLGFVGFSSKPSPIYGGLGLIVSGGVGCGLILSFGGSFLGLMVFLVYLGGMMVVFGYTTAM---AIEDYPETW 82
Cdd:COG0839     6 YIFAALAVASALGVVTSRNPVHAALYLVLTFLSVAGLYLLLGAEFLAAVQVIVYVGAVMVLFLFVVMLldlDKEELREGF 85

                          90       100
                  ....*....|....*....|...
gi 1278971888  83 GSNVAIWSALVFGLFVELIFLAL 105
Cdd:COG0839    86 RKYRPLAALVGLLLLAELAYVLL 108
ND6 MTH00212
NADH dehydrogenase subunit 6; Provisional
 4-74 1.92e-03

NADH dehydrogenase subunit 6; Provisional


Pssm-ID: 214460  Cd Length: 160  Bit Score: 36.91  E-value: 1.92e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1278971888   4 SMYLLSIMFVLGFVgFSSKPSPIYGGLGLIVSGGVGCGLILSFGGSFLGLMVFLVYLGGMMVVFGYTTAMA 74
Cdd:MTH00212    3 LSLLLSLLLLLMLL-FPLSAHPLTLGVSLLLSSLLSCLIITMESNSWYGYILFLIYIGGLLVLFGYMVALS 72
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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