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Conserved domains on  [gi|1280004483|gb|ATY05732|]
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serine dehydratase subunit alpha family protein [Klebsiella aerogenes]

Protein Classification

serine dehydratase subunit alpha family protein( domain architecture ID 10007829)

serine dehydratase subunit alpha family protein such as L-cysteine desulfidase, which catalyzes the cleavage of L-cysteine to form 2-aminoprop-2-enoate and sulfide

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CdsB COG3681
L-cysteine desulfidase YhaM [Amino acid transport and metabolism];
1-425 0e+00

L-cysteine desulfidase YhaM [Amino acid transport and metabolism];


:

Pssm-ID: 442897  Cd Length: 429  Bit Score: 553.60  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1280004483   1 MNTDNASLYVKWLKQEVAPALGCTEPVAISFTAAYAAQYLDQPCTKISGFISANLYKNAMGVTIPGTTVCGVALAAAIGA 80
Cdd:COG3681     1 MDTELYQTLIEILKEEVVPALGCTEPIAVALAAAKAREVLGGEPEKIEVKVSGNIYKNGMGVGIPGTGMKGLEIAAALGA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1280004483  81 FGGNPQKGLKTLEDITPLHVEMAQQLIANNAVDIAVKETPDFIHLDLTLSAGENICRVVVKGTHTNVVELYINGQP--QP 158
Cdd:COG3681    81 VGGDPEKGLEVLKDVTPEDVEKAKELLDEGRVTVELKETDEGLYIEATVKTGDHSARVVIEGSHTNIVLIEKNGEVlfEK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1280004483 159 LSAKQNASARHETLPTFSLQQAYEFINSADFNDIRFILEAARLNSALAAEGKTKKYGLNINGTFADAVKNGLMSNDLLSK 238
Cdd:COG3681   161 ESSAASEESLLEDLKKLSIKDIYDFAEEVDLEDIAFILEGIEMNMAIAEEGLKGKYGLGIGKTLLKQIEKGLLGDDLLSR 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1280004483 239 VIINTVAASDARMGGAPVVAMSNFGSGNQGITATMPVVVVAEHLGADEETLARALSLSHLTAISIHSRYTRLSALCAAST 318
Cdd:COG3681   241 ARALTAAASDARMSGCPLPVMSNSGSGNQGITATLPVVVYAEHLGASEEKLARALALSHLVTIYIKSYIGRLSALCGAVV 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1280004483 319 AAMGAAAGMAWLFTRDINTINTAIINMVSDITGMICDGASNSCAMKVSSVVSSAFKAVLMAMQNSCAGANDGIVCADVEQ 398
Cdd:COG3681   321 AGAGAAAGIAYLLGGDYEQIEGAIKNMLANLSGMICDGAKPSCALKVSTAVSAAILAALMALDGIVVTGGDGIVGEDVEE 400

                         410       420
                  ....*....|....*....|....*..
gi 1280004483 399 TINNLCRLVIKPMALTDKEIISIMVAK 425
Cdd:COG3681   401 TIRNLGRLASEGMKETDKEILEIMLKK 427
 
Name Accession Description Interval E-value
CdsB COG3681
L-cysteine desulfidase YhaM [Amino acid transport and metabolism];
1-425 0e+00

L-cysteine desulfidase YhaM [Amino acid transport and metabolism];


Pssm-ID: 442897  Cd Length: 429  Bit Score: 553.60  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1280004483   1 MNTDNASLYVKWLKQEVAPALGCTEPVAISFTAAYAAQYLDQPCTKISGFISANLYKNAMGVTIPGTTVCGVALAAAIGA 80
Cdd:COG3681     1 MDTELYQTLIEILKEEVVPALGCTEPIAVALAAAKAREVLGGEPEKIEVKVSGNIYKNGMGVGIPGTGMKGLEIAAALGA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1280004483  81 FGGNPQKGLKTLEDITPLHVEMAQQLIANNAVDIAVKETPDFIHLDLTLSAGENICRVVVKGTHTNVVELYINGQP--QP 158
Cdd:COG3681    81 VGGDPEKGLEVLKDVTPEDVEKAKELLDEGRVTVELKETDEGLYIEATVKTGDHSARVVIEGSHTNIVLIEKNGEVlfEK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1280004483 159 LSAKQNASARHETLPTFSLQQAYEFINSADFNDIRFILEAARLNSALAAEGKTKKYGLNINGTFADAVKNGLMSNDLLSK 238
Cdd:COG3681   161 ESSAASEESLLEDLKKLSIKDIYDFAEEVDLEDIAFILEGIEMNMAIAEEGLKGKYGLGIGKTLLKQIEKGLLGDDLLSR 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1280004483 239 VIINTVAASDARMGGAPVVAMSNFGSGNQGITATMPVVVVAEHLGADEETLARALSLSHLTAISIHSRYTRLSALCAAST 318
Cdd:COG3681   241 ARALTAAASDARMSGCPLPVMSNSGSGNQGITATLPVVVYAEHLGASEEKLARALALSHLVTIYIKSYIGRLSALCGAVV 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1280004483 319 AAMGAAAGMAWLFTRDINTINTAIINMVSDITGMICDGASNSCAMKVSSVVSSAFKAVLMAMQNSCAGANDGIVCADVEQ 398
Cdd:COG3681   321 AGAGAAAGIAYLLGGDYEQIEGAIKNMLANLSGMICDGAKPSCALKVSTAVSAAILAALMALDGIVVTGGDGIVGEDVEE 400

                         410       420
                  ....*....|....*....|....*..
gi 1280004483 399 TINNLCRLVIKPMALTDKEIISIMVAK 425
Cdd:COG3681   401 TIRNLGRLASEGMKETDKEILEIMLKK 427
SDH_alpha pfam03313
Serine dehydratase alpha chain; L-serine dehydratase (EC:4.2.1.13) is a found as a heterodimer ...
 193-419 1.79e-47

Serine dehydratase alpha chain; L-serine dehydratase (EC:4.2.1.13) is a found as a heterodimer of alpha and beta chain or as a fusion of the two chains in a single protein. This enzyme catalyzes the deamination of serine to form pyruvate. This enzyme is part of the gluconeogenesis pathway.


Pssm-ID: 427238  Cd Length: 259  Bit Score: 163.35  E-value: 1.79e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1280004483 193 RFILEAARLNSALAAEG--------KTKKYGLNINGTFADavknglmsndllskvIINTVAASDARMGGAPVVAMSNFGS 264
Cdd:pfam03313  36 EFMLEAIEMNLAISEEGllpgglkvRRRNYGLGLGGTLLD---------------KALAAAAADARMNGAMGPVVTAPTS 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1280004483 265 GNQGItatMPVVVVAEHLGADEETLARALSLSHLTAISIHSRYTRLSALC----AASTAAMGAAAGMAWLFTRDINTINT 340
Cdd:pfam03313 101 GNQGI---LPAVLYAEELGASEEKLIRALLLSALIGIYIKKNAGILSAECgcqaEVGSASAMAAAGLAYLLGGTPEQIEN 177

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1280004483 341 AIINMVSDITGMICDG----ASNSCAMKVSSVVSSAFKAVLMAMQNScagANDGIVCAD-VEQTINNLCRLVIKPMALTD 415
Cdd:pfam03313 178 AAENALENLLGLICDPvaglVKVPCAEKNATGAVAAILAALMALAGD---GIDGIVPLDeVIETMRNVGRLMPEGMKETD 254


                  ....
gi 1280004483 416 KEII 419
Cdd:pfam03313 255 LGGL 258
 
Name Accession Description Interval E-value
CdsB COG3681
L-cysteine desulfidase YhaM [Amino acid transport and metabolism];
1-425 0e+00

L-cysteine desulfidase YhaM [Amino acid transport and metabolism];


Pssm-ID: 442897  Cd Length: 429  Bit Score: 553.60  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1280004483   1 MNTDNASLYVKWLKQEVAPALGCTEPVAISFTAAYAAQYLDQPCTKISGFISANLYKNAMGVTIPGTTVCGVALAAAIGA 80
Cdd:COG3681     1 MDTELYQTLIEILKEEVVPALGCTEPIAVALAAAKAREVLGGEPEKIEVKVSGNIYKNGMGVGIPGTGMKGLEIAAALGA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1280004483  81 FGGNPQKGLKTLEDITPLHVEMAQQLIANNAVDIAVKETPDFIHLDLTLSAGENICRVVVKGTHTNVVELYINGQP--QP 158
Cdd:COG3681    81 VGGDPEKGLEVLKDVTPEDVEKAKELLDEGRVTVELKETDEGLYIEATVKTGDHSARVVIEGSHTNIVLIEKNGEVlfEK 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1280004483 159 LSAKQNASARHETLPTFSLQQAYEFINSADFNDIRFILEAARLNSALAAEGKTKKYGLNINGTFADAVKNGLMSNDLLSK 238
Cdd:COG3681   161 ESSAASEESLLEDLKKLSIKDIYDFAEEVDLEDIAFILEGIEMNMAIAEEGLKGKYGLGIGKTLLKQIEKGLLGDDLLSR 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1280004483 239 VIINTVAASDARMGGAPVVAMSNFGSGNQGITATMPVVVVAEHLGADEETLARALSLSHLTAISIHSRYTRLSALCAAST 318
Cdd:COG3681   241 ARALTAAASDARMSGCPLPVMSNSGSGNQGITATLPVVVYAEHLGASEEKLARALALSHLVTIYIKSYIGRLSALCGAVV 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1280004483 319 AAMGAAAGMAWLFTRDINTINTAIINMVSDITGMICDGASNSCAMKVSSVVSSAFKAVLMAMQNSCAGANDGIVCADVEQ 398
Cdd:COG3681   321 AGAGAAAGIAYLLGGDYEQIEGAIKNMLANLSGMICDGAKPSCALKVSTAVSAAILAALMALDGIVVTGGDGIVGEDVEE 400

                         410       420
                  ....*....|....*....|....*..
gi 1280004483 399 TINNLCRLVIKPMALTDKEIISIMVAK 425
Cdd:COG3681   401 TIRNLGRLASEGMKETDKEILEIMLKK 427
SDH_alpha pfam03313
Serine dehydratase alpha chain; L-serine dehydratase (EC:4.2.1.13) is a found as a heterodimer ...
 193-419 1.79e-47

Serine dehydratase alpha chain; L-serine dehydratase (EC:4.2.1.13) is a found as a heterodimer of alpha and beta chain or as a fusion of the two chains in a single protein. This enzyme catalyzes the deamination of serine to form pyruvate. This enzyme is part of the gluconeogenesis pathway.


Pssm-ID: 427238  Cd Length: 259  Bit Score: 163.35  E-value: 1.79e-47
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1280004483 193 RFILEAARLNSALAAEG--------KTKKYGLNINGTFADavknglmsndllskvIINTVAASDARMGGAPVVAMSNFGS 264
Cdd:pfam03313  36 EFMLEAIEMNLAISEEGllpgglkvRRRNYGLGLGGTLLD---------------KALAAAAADARMNGAMGPVVTAPTS 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1280004483 265 GNQGItatMPVVVVAEHLGADEETLARALSLSHLTAISIHSRYTRLSALC----AASTAAMGAAAGMAWLFTRDINTINT 340
Cdd:pfam03313 101 GNQGI---LPAVLYAEELGASEEKLIRALLLSALIGIYIKKNAGILSAECgcqaEVGSASAMAAAGLAYLLGGTPEQIEN 177

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1280004483 341 AIINMVSDITGMICDG----ASNSCAMKVSSVVSSAFKAVLMAMQNScagANDGIVCAD-VEQTINNLCRLVIKPMALTD 415
Cdd:pfam03313 178 AAENALENLLGLICDPvaglVKVPCAEKNATGAVAAILAALMALAGD---GIDGIVPLDeVIETMRNVGRLMPEGMKETD 254


                  ....
gi 1280004483 416 KEII 419
Cdd:pfam03313 255 LGGL 258
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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