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Conserved domains on  [gi|1280007621|gb|ATY08870|]
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GNAT family N-acetyltransferase [Klebsiella aerogenes]

Protein Classification

GNAT family N-acetyltransferase( domain architecture ID 10013485)

GNAT family N-acetyltransferase catalyzes the transfer of an acetyl group from acetyl-CoA to a substrate, similar to Escherichia coli putative N-acetyltransferase ElaA

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK10314 PRK10314
GNAT family N-acetyltransferase;
28-177 2.56e-99

GNAT family N-acetyltransferase;


:

Pssm-ID: 182373 [Multi-domain]  Cd Length: 153  Bit Score: 283.27  E-value: 2.56e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1280007621  28 MMTWQDLHHSELTVAQLYALLKLRSAVFVVEQRCVYQDIDGDDLVGENRHLLGWRDGELVAYARILKSEEEFEPVVIGRV 107
Cdd:PRK10314    1 MIEWQDLHHSELSVSQLYALLQLRCAVFVVEQNCPYQDIDGDDLTGDNRHILGWKNDELVAYARILKSDDDLEPVVIGRV 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1280007621 108 IVSPSVRGEKLGYQLMEQALASCRQNWPQKAIYLGAQAHLQKFYASFGFVPVTEVYDEDGIAHIGMARDI 177
Cdd:PRK10314   81 IVSEALRGEKVGQQLMSKTLESCTRHWPDKPVYLGAQAHLQNFYQSFGFIPVTEVYEEDGIPHIGMAREV 150
 
Name Accession Description Interval E-value
PRK10314 PRK10314
GNAT family N-acetyltransferase;
28-177 2.56e-99

GNAT family N-acetyltransferase;


Pssm-ID: 182373 [Multi-domain]  Cd Length: 153  Bit Score: 283.27  E-value: 2.56e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1280007621  28 MMTWQDLHHSELTVAQLYALLKLRSAVFVVEQRCVYQDIDGDDLVGENRHLLGWRDGELVAYARILKSEEEFEPVVIGRV 107
Cdd:PRK10314    1 MIEWQDLHHSELSVSQLYALLQLRCAVFVVEQNCPYQDIDGDDLTGDNRHILGWKNDELVAYARILKSDDDLEPVVIGRV 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1280007621 108 IVSPSVRGEKLGYQLMEQALASCRQNWPQKAIYLGAQAHLQKFYASFGFVPVTEVYDEDGIAHIGMARDI 177
Cdd:PRK10314   81 IVSEALRGEKVGQQLMSKTLESCTRHWPDKPVYLGAQAHLQNFYQSFGFIPVTEVYEEDGIPHIGMAREV 150
ElaA COG2153
Predicted N-acyltransferase, GNAT family [General function prediction only];
42-178 2.86e-55

Predicted N-acyltransferase, GNAT family [General function prediction only];


Pssm-ID: 441756 [Multi-domain]  Cd Length: 134  Bit Score: 171.14  E-value: 2.86e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1280007621  42 AQLYALLKLRSAVFVVEQR-CVYQDIDGDDLvgENRHLLGWRDGELVAYARILKSEEEFepVVIGRVIVSPSVRGEKLGY 120
Cdd:COG2153     2 EELYDALALRREVFVVEQGvPPYLELDGKDE--DARHLLAYDDGELVATARLLPPGDGE--AKIGRVAVLPEYRGQGLGR 77

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1280007621 121 QLMEQALASCRQNwPQKAIYLGAQAHLQKFYASFGFVPVTEVYDEDGIAHIGMARDIT 178
Cdd:COG2153    78 ALMEAAIEEARER-GARRIVLSAQAHAVGFYEKLGFVPVGEEFLEAGIPHIDMRKPLS 134
Acetyltransf_10 pfam13673
Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase ...
 73-177 3.58e-13

Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 463953 [Multi-domain]  Cd Length: 128  Bit Score: 63.06  E-value: 3.58e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1280007621  73 GENRHLLGWRDGELVAYARILkseeefEPVVIGRVIVSPSVRGEKLGYQLMEQALASCRQNWPQK-AIYLGAQAHLQKFY 151
Cdd:pfam13673  29 GEYFFFVAFEGGQIVGVIALR------DRGHISLLFVDPDYQGQGIGKALLEAVEDYAEKDGIKLsELTVNASPYAVPFY 102

                          90       100
                  ....*....|....*....|....*.
gi 1280007621 152 ASFGFVPVTEVYDEDGIAHIGMARDI 177
Cdd:pfam13673 103 EKLGFRATGPEQEFNGIRFVPMEKEL 128
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 77-132 6.90e-06

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 41.88  E-value: 6.90e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1280007621  77 HLLGWRDGELVAYARILKSEEEFEPVVIGRVIVSPSVRGEKLGYQLMEQALASCRQ 132
Cdd:cd04301     1 FLVAEDDGEIVGFASLSPDGSGGDTAYIGDLAVLPEYRGKGIGSALLEAAEEEARE 56
 
Name Accession Description Interval E-value
PRK10314 PRK10314
GNAT family N-acetyltransferase;
28-177 2.56e-99

GNAT family N-acetyltransferase;


Pssm-ID: 182373 [Multi-domain]  Cd Length: 153  Bit Score: 283.27  E-value: 2.56e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1280007621  28 MMTWQDLHHSELTVAQLYALLKLRSAVFVVEQRCVYQDIDGDDLVGENRHLLGWRDGELVAYARILKSEEEFEPVVIGRV 107
Cdd:PRK10314    1 MIEWQDLHHSELSVSQLYALLQLRCAVFVVEQNCPYQDIDGDDLTGDNRHILGWKNDELVAYARILKSDDDLEPVVIGRV 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1280007621 108 IVSPSVRGEKLGYQLMEQALASCRQNWPQKAIYLGAQAHLQKFYASFGFVPVTEVYDEDGIAHIGMARDI 177
Cdd:PRK10314   81 IVSEALRGEKVGQQLMSKTLESCTRHWPDKPVYLGAQAHLQNFYQSFGFIPVTEVYEEDGIPHIGMAREV 150
ElaA COG2153
Predicted N-acyltransferase, GNAT family [General function prediction only];
42-178 2.86e-55

Predicted N-acyltransferase, GNAT family [General function prediction only];


Pssm-ID: 441756 [Multi-domain]  Cd Length: 134  Bit Score: 171.14  E-value: 2.86e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1280007621  42 AQLYALLKLRSAVFVVEQR-CVYQDIDGDDLvgENRHLLGWRDGELVAYARILKSEEEFepVVIGRVIVSPSVRGEKLGY 120
Cdd:COG2153     2 EELYDALALRREVFVVEQGvPPYLELDGKDE--DARHLLAYDDGELVATARLLPPGDGE--AKIGRVAVLPEYRGQGLGR 77

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1280007621 121 QLMEQALASCRQNwPQKAIYLGAQAHLQKFYASFGFVPVTEVYDEDGIAHIGMARDIT 178
Cdd:COG2153    78 ALMEAAIEEARER-GARRIVLSAQAHAVGFYEKLGFVPVGEEFLEAGIPHIDMRKPLS 134
yhbS COG3153
Predicted N-acetyltransferase YhbS [General function prediction only];
81-177 1.50e-13

Predicted N-acetyltransferase YhbS [General function prediction only];


Pssm-ID: 442387 [Multi-domain]  Cd Length: 142  Bit Score: 64.34  E-value: 1.50e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1280007621  81 WRDGELVAYARILKSEEEFEP--VVIGRVIVSPSVRGEKLGYQLMEQALASCRQnWPQKAIYLGAQAHLQKFYASFGFVP 158
Cdd:COG3153    45 EDDGEIVGHVALSPVDIDGEGpaLLLGPLAVDPEYRGQGIGRALMRAALEAARE-RGARAVVLLGDPSLLPFYERFGFRP 123

                          90
                  ....*....|....*....
gi 1280007621 159 VTEVYDEDGIAHIGMARDI 177
Cdd:COG3153   124 AGELGLTLGPDEVFLAKEL 142
Acetyltransf_10 pfam13673
Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase ...
 73-177 3.58e-13

Acetyltransferase (GNAT) domain; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 463953 [Multi-domain]  Cd Length: 128  Bit Score: 63.06  E-value: 3.58e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1280007621  73 GENRHLLGWRDGELVAYARILkseeefEPVVIGRVIVSPSVRGEKLGYQLMEQALASCRQNWPQK-AIYLGAQAHLQKFY 151
Cdd:pfam13673  29 GEYFFFVAFEGGQIVGVIALR------DRGHISLLFVDPDYQGQGIGKALLEAVEDYAEKDGIKLsELTVNASPYAVPFY 102

                          90       100
                  ....*....|....*....|....*.
gi 1280007621 152 ASFGFVPVTEVYDEDGIAHIGMARDI 177
Cdd:pfam13673 103 EKLGFRATGPEQEFNGIRFVPMEKEL 128
Acetyltransf_1 pfam00583
Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase ...
 44-156 4.00e-11

Acetyltransferase (GNAT) family; This family contains proteins with N-acetyltransferase functions such as Elp3-related proteins.


Pssm-ID: 395465 [Multi-domain]  Cd Length: 116  Bit Score: 57.14  E-value: 4.00e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1280007621  44 LYALLKLRSAVF-VVEQRCVYQDIDGDDLVGENRHLLGWRDGELVAYARILKSEEEFEPVVIGRVIVSPSVRGEKLGYQL 122
Cdd:pfam00583   1 LEALYELLSEEFpEPWPDEPLDLLEDWDEDASEGFFVAEEDGELVGFASLSIIDDEPPVGEIEGLAVAPEYRGKGIGTAL 80

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1280007621 123 MEQALASCRQnWPQKAIYLGAQAH---LQKFYASFGF 156
Cdd:pfam00583  81 LQALLEWARE-RGCERIFLEVAADnlaAIALYEKLGF 116
Acetyltransf_7 pfam13508
Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.
 74-158 1.02e-09

Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.


Pssm-ID: 463905 [Multi-domain]  Cd Length: 84  Bit Score: 52.84  E-value: 1.02e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1280007621  74 ENRHLLGWRDGELVAYARILKSEEEFEPVVIgRVIVSPSVRGEKLGYQLMEQALAsCRQNWPQKAIYLGAQAHLQKFYAS 153
Cdd:pfam13508   2 GGRFFVAEDDGKIVGFAALLPLDDEGALAEL-RLAVHPEYRGQGIGRALLEAAEA-AAKEGGIKLLELETTNRAAAFYEK 79


                  ....*
gi 1280007621 154 FGFVP 158
Cdd:pfam13508  80 LGFEE 84
ArgA COG1246
N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and ...
 81-161 1.57e-09

N-acetylglutamate synthase or related acetyltransferase, GNAT family [Amino acid transport and metabolism]; N-acetylglutamate synthase or related acetyltransferase, GNAT family is part of the Pathway/BioSystem: Arginine biosynthesis


Pssm-ID: 440859 [Multi-domain]  Cd Length: 132  Bit Score: 53.46  E-value: 1.57e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1280007621  81 WRDGELVAYARILKSEEEFepVVIGRVIVSPSVRGEKLGYQLMEQALASCRQNwPQKAIYLGAQAHLQKFYASFGFVPVT 160
Cdd:COG1246    34 EEDGEIVGCAALHPLDEDL--AELRSLAVHPDYRGRGIGRRLLEALLAEAREL-GLKRLFLLTTSAAIHFYEKLGFEEID 110


                  .
gi 1280007621 161 E 161
Cdd:COG1246   111 K 111
RimI COG0456
Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal ...
 104-178 3.89e-07

Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis];


Pssm-ID: 440224 [Multi-domain]  Cd Length: 92  Bit Score: 46.19  E-value: 3.89e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1280007621 104 IGRVIVSPSVRGEKLGYQLMEQALASCRQNWPQKaIYLGAQAH---LQKFYASFGFVPVTEVYDEDGIAHIGMARDIT 178
Cdd:COG0456    16 IEDLAVDPEYRGRGIGRALLEAALERARERGARR-LRLEVREDneaAIALYEKLGFEEVGERPNYYGDDALVMEKELA 92
NAT_SF cd04301
N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer ...
 77-132 6.90e-06

N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; NAT (N-Acyltransferase) is a large superfamily of enzymes that mostly catalyze the transfer of an acyl group to a substrate and are implicated in a variety of functions, ranging from bacterial antibiotic resistance to circadian rhythms in mammals. Members include GCN5-related N-Acetyltransferases (GNAT) such as Aminoglycoside N-acetyltransferases, Histone N-acetyltransferase (HAT) enzymes, and Serotonin N-acetyltransferase, which catalyze the transfer of an acetyl group to a substrate. The kinetic mechanism of most GNATs involves the ordered formation of a ternary complex: the reaction begins with Acetyl Coenzyme A (AcCoA) binding, followed by binding of substrate, then direct transfer of the acetyl group from AcCoA to the substrate, followed by product and subsequent CoA release. Other family members include Arginine/ornithine N-succinyltransferase, Myristoyl-CoA: protein N-myristoyltransferase, and Acyl-homoserinelactone synthase which have a similar catalytic mechanism but differ in types of acyl groups transferred. Leucyl/phenylalanyl-tRNA-protein transferase and FemXAB nonribosomal peptidyltransferases which catalyze similar peptidyltransferase reactions are also included.


Pssm-ID: 173926 [Multi-domain]  Cd Length: 65  Bit Score: 41.88  E-value: 6.90e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1280007621  77 HLLGWRDGELVAYARILKSEEEFEPVVIGRVIVSPSVRGEKLGYQLMEQALASCRQ 132
Cdd:cd04301     1 FLVAEDDGEIVGFASLSPDGSGGDTAYIGDLAVLPEYRGKGIGSALLEAAEEEARE 56
MnaT COG1247
L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];
82-178 1.43e-04

L-amino acid N-acyltransferase MnaT [Amino acid transport and metabolism];


Pssm-ID: 440860 [Multi-domain]  Cd Length: 163  Bit Score: 40.36  E-value: 1.43e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1280007621  82 RDGELV--AYARILKSEEEFEPVVIGRVIVSPSVRGEKLGYQLMEQALASCRQNwPQKAIYLGAQAHLQ---KFYASFGF 156
Cdd:COG1247    59 EDGEVVgfASLGPFRPRPAYRGTAEESIYVDPDARGRGIGRALLEALIERARAR-GYRRLVAVVLADNEasiALYEKLGF 137

                          90       100
                  ....*....|....*....|..
gi 1280007621 157 VPVTEVydEDGIAHIGMARDIT 178
Cdd:COG1247   138 EEVGTL--PEVGFKFGRWLDLV 157
PhnO COG0454
N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, ...
 83-179 5.94e-04

N-acetyltransferase, GNAT superfamily (includes histone acetyltransferase HPA2) [Transcription, General function prediction only];


Pssm-ID: 440222 [Multi-domain]  Cd Length: 136  Bit Score: 38.11  E-value: 5.94e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1280007621  83 DGELVAYARI-LKSEEEFEpvvIGRVIVSPSVRGEKLGYQLMEQALASCRQNWPqKAIYLG---AQAHLQKFYASFGFVP 158
Cdd:COG0454    42 KGEPIGFAGLrRLDDKVLE---LKRLYVLPEYRGKGIGKALLEALLEWARERGC-TALELDtldGNPAAIRFYERLGFKE 117

                          90       100
                  ....*....|....*....|.
gi 1280007621 159 VTEVYDEDGiahIGMARDITT 179
Cdd:COG0454   118 IERYVAYVG---GEFEKELSL 135
COG3393 COG3393
Predicted acetyltransferase, GNAT family [General function prediction only];
85-161 3.59e-03

Predicted acetyltransferase, GNAT family [General function prediction only];


Pssm-ID: 442620 [Multi-domain]  Cd Length: 86  Bit Score: 34.88  E-value: 3.59e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1280007621  85 ELVAYARILKSEEEFepVVIGRVIVSPSVRGEKLGYQLMEQALASCRQNWPQKAIY--LGAQAHLQKFYASFGFVPVTE 161
Cdd:COG3393     1 ELVAMAGVRAESPGV--AEISGVYTHPEYRGRGLASALVAALAREALARGARTPFLyvDADNPAARRLYERLGFRPVGE 77
Acetyltransf_9 pfam13527
Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.
 48-156 8.48e-03

Acetyltransferase (GNAT) domain; This domain catalyzes N-acetyltransferase reactions.


Pssm-ID: 404421 [Multi-domain]  Cd Length: 124  Bit Score: 34.85  E-value: 8.48e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1280007621  48 LKLRSAVFVVEqRCVYQDIDGDDLVGENRHLLGWRDGELVAYARILKSE-----EEFEPVVIGRVIVSPSVRGEKLGYQL 122
Cdd:pfam13527  13 LRLLEYAFQDE-DSPELREYFRPLLEEGRVLGAFDDGELVSTLALYPFElnvpgKTLPAAGITGVATYPEYRGRGVMSRL 91

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1280007621 123 MEQALASCRQNwPQKAIYL-GAQAHlqkFYASFGF 156
Cdd:pfam13527  92 LRRSLEEMRER-GVPLSFLyPSSYP---IYRRFGY 122
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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