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Conserved domains on  [gi|1314859496|gb|AUG16310|]
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transcriptional regulator [Escherichia coli str. K-12 substr. MG1655]

Protein Classification

GntR family transcriptional regulator( domain architecture ID 11448455)

GntR-family transcriptional regulator is one of a group of transcriptional regulators with a conserved N-terminal helix-turn-helix DNA-binding domain and a diverse C-terminal effector-binding and oligomerization domain; controls the expression of genes with diverse biological functions

CATH:  1.10.10.10
Gene Ontology:  GO:0003700|GO:0003677
PubMed:  33509775
SCOP:  4000155

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
GntR COG1802
DNA-binding transcriptional regulator, GntR family [Transcription];
1-223 3.13e-59

DNA-binding transcriptional regulator, GntR family [Transcription];


:

Pssm-ID: 441407 [Multi-domain]  Cd Length: 222  Bit Score: 185.90  E-value: 3.13e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1314859496   1 MTvETQLNPTQPVNQQIYRILRRDIVHCLIAPGTPLSEKEVSVRFNVSRQPVREAFIKLAENGLIQIRPQRGSYVNKISM 80
Cdd:COG1802     1 MT-SPSPLRRESLAEQVYEALREAILSGELPPGERLSEAELAERLGVSRTPVREALRRLEAEGLVEIRPNRGARVAPLSP 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1314859496  81 AQVRNGSFIRQAIECAVARRAASMITESQCYQLEQNLHQQRIAIERKQLDDFFELDDNFHQLLTQIADCQLAWDTIENLK 160
Cdd:COG1802    80 EEIRELYEVRAALEGLAARLAAERATPADLARLRALLEELEAAAAAGDVAAYLELDREFHRALVEAAGNPRLAELLRRLR 159
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1314859496 161 ATVDRVRYMSFDHVSPPEMLLRQHLDIFSALQKRDGDAVERAMTQHLQEISESVRQIRQENSD 223
Cdd:COG1802   160 ARLRRYRRLSLRSPGRLEESLAEHRAILDALEAGDAEAAAAALRAHLERARERLLEALAAAAA 222
 
Name Accession Description Interval E-value
GntR COG1802
DNA-binding transcriptional regulator, GntR family [Transcription];
1-223 3.13e-59

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441407 [Multi-domain]  Cd Length: 222  Bit Score: 185.90  E-value: 3.13e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1314859496   1 MTvETQLNPTQPVNQQIYRILRRDIVHCLIAPGTPLSEKEVSVRFNVSRQPVREAFIKLAENGLIQIRPQRGSYVNKISM 80
Cdd:COG1802     1 MT-SPSPLRRESLAEQVYEALREAILSGELPPGERLSEAELAERLGVSRTPVREALRRLEAEGLVEIRPNRGARVAPLSP 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1314859496  81 AQVRNGSFIRQAIECAVARRAASMITESQCYQLEQNLHQQRIAIERKQLDDFFELDDNFHQLLTQIADCQLAWDTIENLK 160
Cdd:COG1802    80 EEIRELYEVRAALEGLAARLAAERATPADLARLRALLEELEAAAAAGDVAAYLELDREFHRALVEAAGNPRLAELLRRLR 159
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1314859496 161 ATVDRVRYMSFDHVSPPEMLLRQHLDIFSALQKRDGDAVERAMTQHLQEISESVRQIRQENSD 223
Cdd:COG1802   160 ARLRRYRRLSLRSPGRLEESLAEHRAILDALEAGDAEAAAAALRAHLERARERLLEALAAAAA 222
FCD pfam07729
FCD domain; This domain is the C-terminal ligand binding domain of many members of the GntR ...
89-205 6.83e-24

FCD domain; This domain is the C-terminal ligand binding domain of many members of the GntR family. This domain binds to a range of effector molecules, including Lactate, Zn(II), Ni(II), Ca(II), Mg(II), citrate, sugar acids, sialic acid and N-acetylglucosamine-6-P, that regulate the transcription of genes through the action of the N-terminal DNA-binding domain pfam00392 (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043). This domain is found in Swiss:P45427 and Swiss:P31460 that are regulators of sugar biosynthesis operons. It is also in the known structure of FadR where it binds to acyl-coA, the domain is alpha helical. This family has been named as FCD for (FadR C-terminal Domain).


Pssm-ID: 429623 [Multi-domain]  Cd Length: 121  Bit Score: 92.05  E-value: 6.83e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1314859496  89 IRQAIECAVARRAASMITESQCYQLEQNLHQQRIAIERKQLDDFFELDDNFHQLLTQIADCQLAWDTIENLKATVDRVRY 168
Cdd:pfam07729   5 LRAALEPLAARLAAERATDEDLAELEALLEALEAAADAGDLEAFAEADREFHLALAEAAGNPVLARMLESLWDRLRRLRR 84
                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1314859496 169 MSFDHVSPPEMLLRQHLDIFSALQKRDGDAVERAMTQ 205
Cdd:pfam07729  85 LLLSSPGRLRASLEEHRAILDAIRARDPEAARAAMRR 121
FCD smart00895
This entry represents the C-terminal ligand binding domain of many members of the GntR family; ...
89-209 1.57e-21

This entry represents the C-terminal ligand binding domain of many members of the GntR family; This domain probably binds to a range of effector molecules that regulate the transcription of genes through the action of the N-terminal DNA-binding domain. This domain is found in and that are regulators of sugar biosynthesis operons. Many bacterial transcription regulation proteins bind DNA through a helix-turn-helix (HTH) motif, which can be classified into subfamilies on the basis of sequence similarities. The HTH GntR family has many members distributed among diverse bacterial groups that regulate various biological processes. It was named GntR after the Bacillus subtilis repressor of the gluconate operon. In general, these proteins contain a DNA-binding HTH domain at the N terminus, and an effector binding or oligomerisation domain at the C terminus. The winged-helix DNA-binding domain is well conserved in structure for the whole of the GntR family, and is similar in structure to other transcriptional regulator families. The C-terminal effector-binding and oligomerisation domains are more variable and are consequently used to define the subfamilies. Based on the sequence and structure of the C-terminal domains, the GtnR family can be divided into four major groups, as represented by FadR, HutC, MocR and YtrA, as well as some minor groups such as those represented by AraR and PlmA.


Pssm-ID: 214892 [Multi-domain]  Cd Length: 123  Bit Score: 85.87  E-value: 1.57e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1314859496   89 IRQAIECAVARRAASMITESQCYQLEQNLHQQRIAIERK-QLDDFFELDDNFHQLLTQIADCQLAWDTIENLKATVDRVR 167
Cdd:smart00895   5 VRRALEPLAARLAAERATDEDLAALEALLDAMEAAAAAGdDLEEFAELDREFHRALAEAAGNPVLLELLESLRARLRRLR 84
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|..
gi 1314859496  168 YMsfdHVSPPEMLLRQHLDIFSALQKRDGDAVERAMTQHLQE 209
Cdd:smart00895  85 RL---SLEAARRALDEHRAILDAIRARDAEAARAAMREHLEA 123
PRK03837 PRK03837
transcriptional regulator NanR; Provisional
30-222 6.78e-16

transcriptional regulator NanR; Provisional


Pssm-ID: 235166 [Multi-domain]  Cd Length: 241  Bit Score: 73.90  E-value: 6.78e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1314859496  30 IAPGTPL-SEKEVSVRFNVSRQPVREAFIKLAENGLIQI---------RPQRGSYVNKIS-MAQ---------VRNGSFI 89
Cdd:PRK03837   31 FGPGDQLpSERELMAFFGVGRPAVREALQALKRKGLVQIshgerarvsRPSADTIIGQLSgMAKdflsqspdgLAHLKQA 110
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1314859496  90 RQAIECAVARRAASMITESQCYQLEQNLHQQRIAIERkqLDDFFELDDNFHQLLTQIA---------DCQLAWdtienLK 160
Cdd:PRK03837  111 RLFFESSLARYAAEHATDEQIALLRKALERNSQSLGD--NAAFIRSDMEFHRVIAEIPgnpifmaihEALLDW-----LI 183
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1314859496 161 -ATVDRVRYMSFDHVSppemlLRQHLDIFSALQKRDGDAVERAMTQHLQEISESVRQIRQENS 222
Cdd:PRK03837  184 eARPEVVILHGHENVT-----LQEHIAIVDAIRAHDPDEADRALQSHLNRVSALYHALGQTTN 241
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
15-76 1.75e-15

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 68.24  E-value: 1.75e-15
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1314859496  15 QQIYRILRRDIVHCLIAPGTPL-SEKEVSVRFNVSRQPVREAFIKLAENGLIQIRPQRGSYVN 76
Cdd:cd07377     4 EQIADQLREAILSGELKPGDRLpSERELAEELGVSRTTVREALRELEAEGLVERRPGRGTFVA 66
 
Name Accession Description Interval E-value
GntR COG1802
DNA-binding transcriptional regulator, GntR family [Transcription];
1-223 3.13e-59

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441407 [Multi-domain]  Cd Length: 222  Bit Score: 185.90  E-value: 3.13e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1314859496   1 MTvETQLNPTQPVNQQIYRILRRDIVHCLIAPGTPLSEKEVSVRFNVSRQPVREAFIKLAENGLIQIRPQRGSYVNKISM 80
Cdd:COG1802     1 MT-SPSPLRRESLAEQVYEALREAILSGELPPGERLSEAELAERLGVSRTPVREALRRLEAEGLVEIRPNRGARVAPLSP 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1314859496  81 AQVRNGSFIRQAIECAVARRAASMITESQCYQLEQNLHQQRIAIERKQLDDFFELDDNFHQLLTQIADCQLAWDTIENLK 160
Cdd:COG1802    80 EEIRELYEVRAALEGLAARLAAERATPADLARLRALLEELEAAAAAGDVAAYLELDREFHRALVEAAGNPRLAELLRRLR 159
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1314859496 161 ATVDRVRYMSFDHVSPPEMLLRQHLDIFSALQKRDGDAVERAMTQHLQEISESVRQIRQENSD 223
Cdd:COG1802   160 ARLRRYRRLSLRSPGRLEESLAEHRAILDALEAGDAEAAAAALRAHLERARERLLEALAAAAA 222
FadR COG2186
DNA-binding transcriptional regulator, FadR family [Transcription];
15-223 6.35e-37

DNA-binding transcriptional regulator, FadR family [Transcription];


Pssm-ID: 441789 [Multi-domain]  Cd Length: 232  Bit Score: 129.28  E-value: 6.35e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1314859496  15 QQIYRILRRDIVHCLIAPGTPL-SEKEVSVRFNVSRQPVREAFIKLAENGLIQIRPQRGSYVNKIS----------MAQV 83
Cdd:COG2186    10 EQVAEQLRELILSGELKPGDRLpSERELAEQLGVSRTTVREALRALEALGLVEVRQGGGTFVREPSpwalldplalLLAL 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1314859496  84 RNGSF-----IRQAIECAVARRAASMITESQCYQLEQNLHQQRIAIERkqLDDFFELDDNFHQLLTQIADCQLAWDTIEN 158
Cdd:COG2186    90 DDASLrdlleARLALEPEAARLAAERATDEDLARLEAALAEMEAAADD--GEAFAEADLAFHRAIAEASGNPLLALLLES 167
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1314859496 159 LKATVDRVRYMSFDHVSPPEMLLRQHLDIFSALQKRDGDAVERAMTQHLQEISESVRQIRQENSD 223
Cdd:COG2186   168 LRELLRRSVRLTLRSPEARERSLAEHRAILDAIRAGDPEAARAAMRAHLEAVRERLREALAERAR 232
FCD pfam07729
FCD domain; This domain is the C-terminal ligand binding domain of many members of the GntR ...
89-205 6.83e-24

FCD domain; This domain is the C-terminal ligand binding domain of many members of the GntR family. This domain binds to a range of effector molecules, including Lactate, Zn(II), Ni(II), Ca(II), Mg(II), citrate, sugar acids, sialic acid and N-acetylglucosamine-6-P, that regulate the transcription of genes through the action of the N-terminal DNA-binding domain pfam00392 (Matilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043). This domain is found in Swiss:P45427 and Swiss:P31460 that are regulators of sugar biosynthesis operons. It is also in the known structure of FadR where it binds to acyl-coA, the domain is alpha helical. This family has been named as FCD for (FadR C-terminal Domain).


Pssm-ID: 429623 [Multi-domain]  Cd Length: 121  Bit Score: 92.05  E-value: 6.83e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1314859496  89 IRQAIECAVARRAASMITESQCYQLEQNLHQQRIAIERKQLDDFFELDDNFHQLLTQIADCQLAWDTIENLKATVDRVRY 168
Cdd:pfam07729   5 LRAALEPLAARLAAERATDEDLAELEALLEALEAAADAGDLEAFAEADREFHLALAEAAGNPVLARMLESLWDRLRRLRR 84
                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1314859496 169 MSFDHVSPPEMLLRQHLDIFSALQKRDGDAVERAMTQ 205
Cdd:pfam07729  85 LLLSSPGRLRASLEEHRAILDAIRARDPEAARAAMRR 121
FCD smart00895
This entry represents the C-terminal ligand binding domain of many members of the GntR family; ...
89-209 1.57e-21

This entry represents the C-terminal ligand binding domain of many members of the GntR family; This domain probably binds to a range of effector molecules that regulate the transcription of genes through the action of the N-terminal DNA-binding domain. This domain is found in and that are regulators of sugar biosynthesis operons. Many bacterial transcription regulation proteins bind DNA through a helix-turn-helix (HTH) motif, which can be classified into subfamilies on the basis of sequence similarities. The HTH GntR family has many members distributed among diverse bacterial groups that regulate various biological processes. It was named GntR after the Bacillus subtilis repressor of the gluconate operon. In general, these proteins contain a DNA-binding HTH domain at the N terminus, and an effector binding or oligomerisation domain at the C terminus. The winged-helix DNA-binding domain is well conserved in structure for the whole of the GntR family, and is similar in structure to other transcriptional regulator families. The C-terminal effector-binding and oligomerisation domains are more variable and are consequently used to define the subfamilies. Based on the sequence and structure of the C-terminal domains, the GtnR family can be divided into four major groups, as represented by FadR, HutC, MocR and YtrA, as well as some minor groups such as those represented by AraR and PlmA.


Pssm-ID: 214892 [Multi-domain]  Cd Length: 123  Bit Score: 85.87  E-value: 1.57e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1314859496   89 IRQAIECAVARRAASMITESQCYQLEQNLHQQRIAIERK-QLDDFFELDDNFHQLLTQIADCQLAWDTIENLKATVDRVR 167
Cdd:smart00895   5 VRRALEPLAARLAAERATDEDLAALEALLDAMEAAAAAGdDLEEFAELDREFHRALAEAAGNPVLLELLESLRARLRRLR 84
                           90       100       110       120
                   ....*....|....*....|....*....|....*....|..
gi 1314859496  168 YMsfdHVSPPEMLLRQHLDIFSALQKRDGDAVERAMTQHLQE 209
Cdd:smart00895  85 RL---SLEAARRALDEHRAILDAIRARDAEAARAAMREHLEA 123
HTH_GNTR smart00345
helix_turn_helix gluconate operon transcriptional repressor;
17-75 2.28e-17

helix_turn_helix gluconate operon transcriptional repressor;


Pssm-ID: 197669 [Multi-domain]  Cd Length: 60  Bit Score: 73.38  E-value: 2.28e-17
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1314859496   17 IYRILRRDIVHCLIAPGTPL-SEKEVSVRFNVSRQPVREAFIKLAENGLIQIRPQRGSYV 75
Cdd:smart00345   1 VAERLREDIVSGELRPGDKLpSERELAAQLGVSRTTVREALSRLEAEGLVQRRPGSGTFV 60
PRK03837 PRK03837
transcriptional regulator NanR; Provisional
30-222 6.78e-16

transcriptional regulator NanR; Provisional


Pssm-ID: 235166 [Multi-domain]  Cd Length: 241  Bit Score: 73.90  E-value: 6.78e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1314859496  30 IAPGTPL-SEKEVSVRFNVSRQPVREAFIKLAENGLIQI---------RPQRGSYVNKIS-MAQ---------VRNGSFI 89
Cdd:PRK03837   31 FGPGDQLpSERELMAFFGVGRPAVREALQALKRKGLVQIshgerarvsRPSADTIIGQLSgMAKdflsqspdgLAHLKQA 110
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1314859496  90 RQAIECAVARRAASMITESQCYQLEQNLHQQRIAIERkqLDDFFELDDNFHQLLTQIA---------DCQLAWdtienLK 160
Cdd:PRK03837  111 RLFFESSLARYAAEHATDEQIALLRKALERNSQSLGD--NAAFIRSDMEFHRVIAEIPgnpifmaihEALLDW-----LI 183
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1314859496 161 -ATVDRVRYMSFDHVSppemlLRQHLDIFSALQKRDGDAVERAMTQHLQEISESVRQIRQENS 222
Cdd:PRK03837  184 eARPEVVILHGHENVT-----LQEHIAIVDAIRAHDPDEADRALQSHLNRVSALYHALGQTTN 241
WHTH_GntR cd07377
Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional ...
15-76 1.75e-15

Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; This CD represents the winged HTH DNA-binding domain of the GntR (named after the gluconate operon repressor in Bacillus subtilis) family of bacterial transcriptional regulators and their putative homologs found in eukaryota and archaea. The GntR family has over 6000 members distributed among almost all bacterial species, which is comprised of FadR, HutC, MocR, YtrA, AraR, PlmA, and other subfamilies for the regulation of the most varied biological process. The monomeric proteins of the GntR family are characterized by two function domains: a small highly conserved winged helix-turn-helix prokaryotic DNA binding domain in the N-terminus, and a very diverse regulatory ligand-binding domain in the C-terminus for effector-binding/oligomerization, which provides the basis for the subfamily classifications. Binding of the effector to GntR-like transcriptional regulators is presumed to result in a conformational change that regulates the DNA-binding affinity of the repressor. The GntR-like proteins bind as dimers, where each monomer recognizes a half-site of 2-fold symmetric DNA sequences.


Pssm-ID: 153418 [Multi-domain]  Cd Length: 66  Bit Score: 68.24  E-value: 1.75e-15
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1314859496  15 QQIYRILRRDIVHCLIAPGTPL-SEKEVSVRFNVSRQPVREAFIKLAENGLIQIRPQRGSYVN 76
Cdd:cd07377     4 EQIADQLREAILSGELKPGDRLpSERELAEELGVSRTTVREALRELEAEGLVERRPGRGTFVA 66
GntR pfam00392
Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the ...
15-75 4.95e-15

Bacterial regulatory proteins, gntR family; This family of regulatory proteins consists of the N-terminal HTH region of GntR-like bacterial transcription factors. At the C-terminus there is usually an effector-binding/oligomerization domain. The GntR-like proteins include the following sub-families: MocR, YtrR, FadR, AraR, HutC and PlmA, DevA, DasR. Many of these proteins have been shown experimentally to be autoregulatory, enabling the prediction of operator sites and the discovery of cis/trans relationships. The DasR regulator has been shown to be a global regulator of primary metabolism and development in Streptomyces coelicolor.


Pssm-ID: 306822 [Multi-domain]  Cd Length: 64  Bit Score: 67.25  E-value: 4.95e-15
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1314859496  15 QQIYRILRRDIVHCLIAPGTPL-SEKEVSVRFNVSRQPVREAFIKLAENGLIQIRPQRGSYV 75
Cdd:pfam00392   3 EQVYARLREDILSGRLRPGDKLpSERELAAEFGVSRTTVREALRRLEAEGLVERRQGRGTFV 64
MngR COG2188
DNA-binding transcriptional regulator, GntR family [Transcription];
8-77 1.40e-11

DNA-binding transcriptional regulator, GntR family [Transcription];


Pssm-ID: 441791 [Multi-domain]  Cd Length: 238  Bit Score: 61.80  E-value: 1.40e-11
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1314859496   8 NPTQPVNQQIYRILRRDIVHCLIAPGTPL-SEKEVSVRFNVSRQPVREAFIKLAENGLIQIRPQRGSYVNK 77
Cdd:COG2188     1 SSPVPLYLQIADALRERIESGELPPGDRLpSERELAEEFGVSRMTVRKALDELVEEGLLERRQGRGTFVAE 71
PRK10225 PRK10225
Uxu operon transcriptional regulator;
15-212 3.47e-10

Uxu operon transcriptional regulator;


Pssm-ID: 182318 [Multi-domain]  Cd Length: 257  Bit Score: 58.11  E-value: 3.47e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1314859496  15 QQIYRILRRDIVHCLIAPGTPLS-EKEVSVRFNVSRQPVREAFIKLAENGLIQIRPQRGSYV------NKISMAQVRN-- 85
Cdd:PRK10225   12 QEVGAMIRDLIIKTPYNPGERLPpEREIAEMLDVTRTVVREALIMLEIKGLVEVRRGAGIYVldssgsHNTDSPDANVcn 91
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1314859496  86 --GSF----IRQAIECAVARRAASMITESQCYQLEQNLHQQRIAIERKQLDDFFELDDNFHQLLTQIADCQL-------A 152
Cdd:PRK10225   92 daGPFellqARQLLESNIAEFAALQATREDIVKMRQALQLEERELASSAPGSSESGDMQFHLAIAEATHNSMlvelfrqS 171
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1314859496 153 WDTIENLKATVDRVRYMSFDHVSppEMLLRQHLDIFSALQKRDGDAVERAMTQHLQEISE 212
Cdd:PRK10225  172 WQWRENNPMWIQLHSHLDDSLYR--KEWLGDHKQILAALIKKDARAAKLAMWQHLENVKQ 229
ARO8 COG1167
DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain ...
1-76 1.97e-09

DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain [Transcription, Amino acid transport and metabolism]; DNA-binding transcriptional regulator, MocR family, contains an aminotransferase domain is part of the Pathway/BioSystem: Lysine biosynthesis


Pssm-ID: 440781 [Multi-domain]  Cd Length: 471  Bit Score: 56.76  E-value: 1.97e-09
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1314859496   1 MTVETQLNPTQPVNQQIYRILRRDIVHCLIAPGTPL-SEKEVSVRFNVSRQPVREAFIKLAENGLIQIRPQRGSYVN 76
Cdd:COG1167     1 MLIRLDRDSSGPLYLQLADALREAILSGRLPPGDRLpSSRELAAQLGVSRSTVVRAYEELEAEGLIESRPGSGTFVA 77
PRK11414 PRK11414
GntR family transcriptional regulator;
32-216 5.17e-05

GntR family transcriptional regulator;


Pssm-ID: 183126 [Multi-domain]  Cd Length: 221  Bit Score: 42.94  E-value: 5.17e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1314859496  32 PGTPLSEKEVSVRFNVSRQPVREAFIKLAENGLIQIRPQRGSYVNKISMAQVRNGSFIRQAIECAVARRAASMITESQCY 111
Cdd:PRK11414   31 PGARLITKNLAEQLGMSITPVREALLRLVSVNALSVAPAQAFTVPEVSKRQLDEINRIRYELELMAVALAVENLTPQDLA 110
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1314859496 112 QLEQNLHQQRIAIERKQLDDFFELDDNFHQLLTQIADCQLAWDTIENLKATVDRVRYMSFDHVSPPEmlLRQHLD----I 187
Cdd:PRK11414  111 ELQELLEKLQQAQEKGDMEQIINANRLFRLAIYHRSNMPILCEMIEQLWVRMGPSLHYLYEAINPAE--LREHIEnyrlL 188
                         170       180
                  ....*....|....*....|....*....
gi 1314859496 188 FSALQKRDGDAVERAMTQHLQEISESVRQ 216
Cdd:PRK11414  189 LAALKAKDKEGCRHCLAEIMQQNVAILYQ 217
PRK11523 PRK11523
transcriptional regulator ExuR;
15-208 1.54e-04

transcriptional regulator ExuR;


Pssm-ID: 183176 [Multi-domain]  Cd Length: 253  Bit Score: 41.75  E-value: 1.54e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1314859496  15 QQIYRILRRDIVHCLIAPGTPL-SEKEVSVRFNVSRQPVREAFIKLAENGLIQIRpqRGSYVNKISMAQ----------- 82
Cdd:PRK11523   11 QQLAAELKERIEQGVYLVGDKLpAERFIADEKNVSRTVVREAIIMLEVEGYVEVR--KGSGIHVVSNQPrhqqaadnnme 88
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1314859496  83 -VRNGSF----IRQAIECAVARRAASMITESQCYQLeqnlhqqrIAI-ERKQLDDFF---ELDDNFHqlltqiadCQLAW 153
Cdd:PRK11523   89 fANYGPFellqARQLIESNIAEFAATQVTKQDIMKL--------MAIqEQARGEDCFrdsEWDLQFH--------VQVAL 152
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1314859496 154 DTIENLKATVdrVRYMSFDHVSPPEML-LRQHLD-------------IFSALQKRDGDAVERAMTQHLQ 208
Cdd:PRK11523  153 ATQNSALAAI--VEKMWTQRSHNPYWKkLHEHIDdrtvdnwcddhdqILKALIRKDPHAAKLAMWQHLE 219
PRK10421 PRK10421
DNA-binding transcriptional repressor LldR; Provisional
12-226 1.20e-03

DNA-binding transcriptional repressor LldR; Provisional


Pssm-ID: 236690 [Multi-domain]  Cd Length: 253  Bit Score: 38.98  E-value: 1.20e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1314859496  12 PVNQQIYRILRRDIVHCLIAPGTPL-SEKEVSVRFNVSRQPVREAFIKLAENGLIQIRPQRGSY-------------VNK 77
Cdd:PRK10421    2 RLSDEVADRVRALIEEKNLEAGMKLpAERQLAMQLGVSRNSLREALAKLVSEGVLLSRRGGGTFirwrhetwseqniVQP 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1314859496  78 IS--MAQVRNGSF----IRQAIECAVARRAASMITESQcyqlEQNLHQQRIAIERKQLDDFFELDDNFHqllTQIADC-- 149
Cdd:PRK10421   82 LKtlMADDPDYSFdileARHAIEASTAWHAAMRATPGD----KEKIQLCFEATLSEDPDLASQADVRFH---LAIAEAsh 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1314859496 150 -----QLAWDTIENLKATVDRVRYMSFDHVSPPEMLLRQHLDIFSALQKRDGDAVERAMTQHLQEISESVR-----QIRQ 219
Cdd:PRK10421  155 nvvllQTMRGFFDVLQSSVKQSRQRMYLVPPVFSQLTEQHQAVMDAILAGDAEGARKAMMAHLSFVHTTIKrfdedQARQ 234

                  ....*..
gi 1314859496 220 ENSDWFS 226
Cdd:PRK10421  235 ARITRLP 241
PRK11534 PRK11534
DNA-binding transcriptional regulator CsiR; Provisional
9-221 2.16e-03

DNA-binding transcriptional regulator CsiR; Provisional


Pssm-ID: 183181 [Multi-domain]  Cd Length: 224  Bit Score: 37.95  E-value: 2.16e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1314859496   9 PTQPVNQQIYRILRRDIVHCLIAPGTPLSEKEVSVRFNVSRQPVREAFIKLAENGLIQIRPQRGSYVNKISMAQVRN--- 85
Cdd:PRK11534    4 PMQITALDGYRWLKNDIIRGNFQPDEKLRMSLLTSRYALGVGPLREALSQLVAERLVTVVNQKGYRVASMSEQELLDifd 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1314859496  86 ------GSFIRQAIECAVARRAASMITESQCYQLEQNLHQQriaieRKQLDDFFELDDNFHQLLTQIADCQLAWDTIENL 159
Cdd:PRK11534   84 aranmeAMLVSLAIARGGDEWEADVLAKAHLLSKLEACDAS-----EKMLDEWDLRHQAFHTAIVAGCGSHYLLQMRERL 158
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1314859496 160 KATVDRVRYMSFDH-VSPPEML---LRQHLDIFSALQKRDGDAVERAMTQHLQEISESVRQIRQEN 221
Cdd:PRK11534  159 FDLAARYRFIWLRRtVLSVEMLedkHDQHQTLTAAILARDTARASELMRQHLLTPIPIIQQAMAGN 224
pdhR PRK09464
pyruvate dehydrogenase complex transcriptional repressor PdhR;
9-77 4.92e-03

pyruvate dehydrogenase complex transcriptional repressor PdhR;


Pssm-ID: 181879 [Multi-domain]  Cd Length: 254  Bit Score: 37.31  E-value: 4.92e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1314859496   9 PTQPVNQQ-----IYRILRRDIVHCLIAPGTPL-SEKEVSVRFNVSRQPVREAFIKLAENGLIQIRPQRGSYVNK 77
Cdd:PRK09464    2 AYSKIRQPklsdvIEQQLEFLILEGTLRPGEKLpPERELAKQFDVSRPSLREAIQRLEAKGLLLRRQGGGTFVQS 76
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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