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Conserved domains on  [gi|1314859998|gb|AUG16812|]
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protein-tyrosine-phosphatase [Escherichia coli str. K-12 substr. MG1655]

Protein Classification

low molecular weight protein-tyrosine-phosphatase Wzb( domain architecture ID 10793344)

low molecular weight protein-tyrosine-phosphatase Wzb dephosphorylates Wzc is required for the extracellular polysaccharide colanic acid synthesis

CATH:  3.40.50.2300
EC:  3.1.3.48
Gene Ontology:  GO:0006470|GO:0000271|GO:0004725
SCOP:  4000436

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK10126 PRK10126
low molecular weight protein-tyrosine-phosphatase Wzb;
1-147 2.23e-109

low molecular weight protein-tyrosine-phosphatase Wzb;


:

Pssm-ID: 182256  Cd Length: 147  Bit Score: 306.84  E-value: 2.23e-109
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1314859998   1 MFNNILVVCVGNICRSPTAERLLQRYHPELKVESAGLGALVGKGADPTAISVAAEHQLSLEGHCARQISRRLCRNYDLIL 80
Cdd:PRK10126    1 MFNNILVVCVGNICRSPTAERLLQRYHPELKVESAGLGALVGKGADPTAISVAAEHQLSLEGHCARQISRRLCRNYDLIL 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1314859998  81 TMEKRHIERLCEMAPEMRGKVMLFGHWDNECEIPDPYRKSRETFAAVYTLLERSARQWAQALNAEQV 147
Cdd:PRK10126   81 TMEKRHIERLCEMAPEMRGKVMLFGHWDNECEIPDPYRKSREAFEAVYTLLERSARQWAQALNAEQV 147
 
Name Accession Description Interval E-value
PRK10126 PRK10126
low molecular weight protein-tyrosine-phosphatase Wzb;
1-147 2.23e-109

low molecular weight protein-tyrosine-phosphatase Wzb;


Pssm-ID: 182256  Cd Length: 147  Bit Score: 306.84  E-value: 2.23e-109
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1314859998   1 MFNNILVVCVGNICRSPTAERLLQRYHPELKVESAGLGALVGKGADPTAISVAAEHQLSLEGHCARQISRRLCRNYDLIL 80
Cdd:PRK10126    1 MFNNILVVCVGNICRSPTAERLLQRYHPELKVESAGLGALVGKGADPTAISVAAEHQLSLEGHCARQISRRLCRNYDLIL 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1314859998  81 TMEKRHIERLCEMAPEMRGKVMLFGHWDNECEIPDPYRKSRETFAAVYTLLERSARQWAQALNAEQV 147
Cdd:PRK10126   81 TMEKRHIERLCEMAPEMRGKVMLFGHWDNECEIPDPYRKSREAFEAVYTLLERSARQWAQALNAEQV 147
LMWPTP cd16343
Low molecular weight protein tyrosine phosphatase; Low molecular weight protein tyrosine ...
 3-140 1.47e-62

Low molecular weight protein tyrosine phosphatase; Low molecular weight protein tyrosine phosphatases (LMW-PTP) are a family of small soluble single-domain enzymes that are characterized by a highly conserved active site motif (V/I)CXGNXCRS and share no sequence similarity with other types of protein tyrosine phosphatases (PTPs). LMW-PTPs play important roles in many biological processes and are widely distributed in prokaryotes and eukaryotes.


Pssm-ID: 319971  Cd Length: 147  Bit Score: 188.42  E-value: 1.47e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1314859998   3 NNILVVCVGNICRSPTAERLLQRYHPE-----LKVESAGLGAL-VGKGADPTAISVAAEHQLSLEGHCARQISRRLCRNY 76
Cdd:cd16343     1 KKILFVCLGNICRSPMAEAVLRHLLPKaggddVEVDSAGTSAWhGGEPPDPRARAVLKEHGIDLSGHRARQLTAEDFDEF 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1314859998  77 DLILTMEKRHIERLCEMAPEM-RGKVMLFGHWDNEC--EIPDPYRKSRETFAAVYTLLERSARQWAQ 140
Cdd:cd16343    81 DLILAMDESNLRDLRRLAPAEaRGKVFLLGDFDPEGgkDVPDPYYGGREGFEEVYDLIERACEGLLE 147
LMWPc pfam01451
Low molecular weight phosphotyrosine protein phosphatase;
5-139 1.19e-59

Low molecular weight phosphotyrosine protein phosphatase;


Pssm-ID: 460216  Cd Length: 142  Bit Score: 181.03  E-value: 1.19e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1314859998   5 ILVVCVGNICRSPTAERLLQRYHPE------LKVESAGLGALVGKGADPTAISVAAEHQLSLEGHCARQISRRLCRNYDL 78
Cdd:pfam01451   1 ILFVCTGNICRSPMAEAIFRRELEKaglgdkVEVDSAGTGAWPGNPADPRAVEVLKEHGIDLSGHYARQLSTEDFASFDL 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1314859998  79 ILTMEKRHIERLCEMAPE-MRGKVMLFGHWDNECEIPDPYRKSRETFAAVYTLLERSARQWA 139
Cdd:pfam01451  81 ILAMDSEHKRDLCPLAPErYRAKVMLLGEYGEQLDIPDPYYGSIDAFEEVRDLIERRCRQLL 142
LMWPc smart00226
Low molecular weight phosphatase family;
5-141 2.46e-50

Low molecular weight phosphatase family;


Pssm-ID: 197586  Cd Length: 134  Bit Score: 157.25  E-value: 2.46e-50
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1314859998    5 ILVVCVGNICRSPTAERLLQRYHP-ELKVESAGLGALVGKGADPTAISVAAEHQLSLEgHCARQISRRLCRNYDLILTME 83
Cdd:smart00226   1 ILFVCTGNICRSPMAEALFKAYVGdRVKIDSAGTGAWVGGGADPRAVKVLKEHGIDLS-HHASQLTSSDFKNADLVLAMD 79

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1314859998   84 KRHIERLCEMAPEMRGKVMLFGHWDnecEIPDPYRKSRETFAAVYTLLERSARQWAQA 141
Cdd:smart00226  80 GSHLRNICRLKPPSRAKVELFGHYV---DVDDPYYGGIDGFERVYDELENALQEFLKQ 134
Wzb COG0394
Protein-tyrosine-phosphatase [Signal transduction mechanisms];
1-144 1.03e-48

Protein-tyrosine-phosphatase [Signal transduction mechanisms];


Pssm-ID: 440163  Cd Length: 137  Bit Score: 153.01  E-value: 1.03e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1314859998   1 MFNNILVVCVGNICRSPTAERLLQRYHPE-LKVESAGLGAlvGKGADPTAISVAAEHQLSLEGHCARQISRRLCRNYDLI 79
Cdd:COG0394     2 MPKRVLFVCTGNICRSPMAEALLRHLAGGrVEVDSAGTEP--GGPVDPRAVAVLAERGIDLSGHRSRQLDEEDLPEFDLV 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1314859998  80 LTMEKRHIERLCEMAPemrGKVMLFGHWDneceIPDPYRKSRETFAAVYTLLERSARQWAQALNA 144
Cdd:COG0394    80 ITMCDSAAEELCPLFP---GAAKLLLHWD----VPDPYYGGLEAFREVRDEIERRIEALLAKLRR 137
 
Name Accession Description Interval E-value
PRK10126 PRK10126
low molecular weight protein-tyrosine-phosphatase Wzb;
1-147 2.23e-109

low molecular weight protein-tyrosine-phosphatase Wzb;


Pssm-ID: 182256  Cd Length: 147  Bit Score: 306.84  E-value: 2.23e-109
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1314859998   1 MFNNILVVCVGNICRSPTAERLLQRYHPELKVESAGLGALVGKGADPTAISVAAEHQLSLEGHCARQISRRLCRNYDLIL 80
Cdd:PRK10126    1 MFNNILVVCVGNICRSPTAERLLQRYHPELKVESAGLGALVGKGADPTAISVAAEHQLSLEGHCARQISRRLCRNYDLIL 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1314859998  81 TMEKRHIERLCEMAPEMRGKVMLFGHWDNECEIPDPYRKSRETFAAVYTLLERSARQWAQALNAEQV 147
Cdd:PRK10126   81 TMEKRHIERLCEMAPEMRGKVMLFGHWDNECEIPDPYRKSREAFEAVYTLLERSARQWAQALNAEQV 147
LMWPTP cd16343
Low molecular weight protein tyrosine phosphatase; Low molecular weight protein tyrosine ...
 3-140 1.47e-62

Low molecular weight protein tyrosine phosphatase; Low molecular weight protein tyrosine phosphatases (LMW-PTP) are a family of small soluble single-domain enzymes that are characterized by a highly conserved active site motif (V/I)CXGNXCRS and share no sequence similarity with other types of protein tyrosine phosphatases (PTPs). LMW-PTPs play important roles in many biological processes and are widely distributed in prokaryotes and eukaryotes.


Pssm-ID: 319971  Cd Length: 147  Bit Score: 188.42  E-value: 1.47e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1314859998   3 NNILVVCVGNICRSPTAERLLQRYHPE-----LKVESAGLGAL-VGKGADPTAISVAAEHQLSLEGHCARQISRRLCRNY 76
Cdd:cd16343     1 KKILFVCLGNICRSPMAEAVLRHLLPKaggddVEVDSAGTSAWhGGEPPDPRARAVLKEHGIDLSGHRARQLTAEDFDEF 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1314859998  77 DLILTMEKRHIERLCEMAPEM-RGKVMLFGHWDNEC--EIPDPYRKSRETFAAVYTLLERSARQWAQ 140
Cdd:cd16343    81 DLILAMDESNLRDLRRLAPAEaRGKVFLLGDFDPEGgkDVPDPYYGGREGFEEVYDLIERACEGLLE 147
etp PRK11391
phosphotyrosine-protein phosphatase; Provisional
 1-143 1.56e-62

phosphotyrosine-protein phosphatase; Provisional


Pssm-ID: 138553  Cd Length: 144  Bit Score: 188.30  E-value: 1.56e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1314859998   1 MFNNILVVCVGNICRSPTAERLLQRYHPELKVESAGLGALVGKGADPTAISVAAEHQLSLEGHCARQISRRLCRNYDLIL 80
Cdd:PRK11391    1 KFNSILVVCTGNICRSPIGERLLRKRLPGVKVKSAGVHGLVKHPADATAADVAANHGVSLEGHAGRKLTAEMARNYDLIL 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1314859998  81 TMEKRHIERLCEMAPEMRGKVMLFGHWDNECEIPDPYRKSRETFAAVYTLLERSARQWAQALN 143
Cdd:PRK11391   81 AMESEHIAQVTAIAPEVRGKTMLFGQWLEQKEIPDPYRKSQDAFEHVYGMLERASQEWAKRLS 143
LMWPc pfam01451
Low molecular weight phosphotyrosine protein phosphatase;
5-139 1.19e-59

Low molecular weight phosphotyrosine protein phosphatase;


Pssm-ID: 460216  Cd Length: 142  Bit Score: 181.03  E-value: 1.19e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1314859998   5 ILVVCVGNICRSPTAERLLQRYHPE------LKVESAGLGALVGKGADPTAISVAAEHQLSLEGHCARQISRRLCRNYDL 78
Cdd:pfam01451   1 ILFVCTGNICRSPMAEAIFRRELEKaglgdkVEVDSAGTGAWPGNPADPRAVEVLKEHGIDLSGHYARQLSTEDFASFDL 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1314859998  79 ILTMEKRHIERLCEMAPE-MRGKVMLFGHWDNECEIPDPYRKSRETFAAVYTLLERSARQWA 139
Cdd:pfam01451  81 ILAMDSEHKRDLCPLAPErYRAKVMLLGEYGEQLDIPDPYYGSIDAFEEVRDLIERRCRQLL 142
LMWPc smart00226
Low molecular weight phosphatase family;
5-141 2.46e-50

Low molecular weight phosphatase family;


Pssm-ID: 197586  Cd Length: 134  Bit Score: 157.25  E-value: 2.46e-50
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1314859998    5 ILVVCVGNICRSPTAERLLQRYHP-ELKVESAGLGALVGKGADPTAISVAAEHQLSLEgHCARQISRRLCRNYDLILTME 83
Cdd:smart00226   1 ILFVCTGNICRSPMAEALFKAYVGdRVKIDSAGTGAWVGGGADPRAVKVLKEHGIDLS-HHASQLTSSDFKNADLVLAMD 79

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1314859998   84 KRHIERLCEMAPEMRGKVMLFGHWDnecEIPDPYRKSRETFAAVYTLLERSARQWAQA 141
Cdd:smart00226  80 GSHLRNICRLKPPSRAKVELFGHYV---DVDDPYYGGIDGFERVYDELENALQEFLKQ 134
Wzb COG0394
Protein-tyrosine-phosphatase [Signal transduction mechanisms];
1-144 1.03e-48

Protein-tyrosine-phosphatase [Signal transduction mechanisms];


Pssm-ID: 440163  Cd Length: 137  Bit Score: 153.01  E-value: 1.03e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1314859998   1 MFNNILVVCVGNICRSPTAERLLQRYHPE-LKVESAGLGAlvGKGADPTAISVAAEHQLSLEGHCARQISRRLCRNYDLI 79
Cdd:COG0394     2 MPKRVLFVCTGNICRSPMAEALLRHLAGGrVEVDSAGTEP--GGPVDPRAVAVLAERGIDLSGHRSRQLDEEDLPEFDLV 79

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1314859998  80 LTMEKRHIERLCEMAPemrGKVMLFGHWDneceIPDPYRKSRETFAAVYTLLERSARQWAQALNA 144
Cdd:COG0394    80 ITMCDSAAEELCPLFP---GAAKLLLHWD----VPDPYYGGLEAFREVRDEIERRIEALLAKLRR 137
LMWP cd00115
Low molecular weight phosphatase family; Low molecular weight phosphatases (LMWPs) are a group ...
 5-140 5.63e-44

Low molecular weight phosphatase family; Low molecular weight phosphatases (LMWPs) are a group of small soluble enzymes that are characterized by a highly conserved active site motif (V/I)CXGNXCRS and share no sequence similarity with other types of protein tyrosine phosphatases (PTPs). This family includes protein tyrosine phosphatases, arginine phosphatases and arsenate reductases.


Pssm-ID: 319970  Cd Length: 137  Bit Score: 141.09  E-value: 5.63e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1314859998   5 ILVVCVGNICRSPTAERLLQRY-HPELKVESAGLGALVGKGADPTAISVAAEHQLSLEgHCARQISRRLCRNYDLILTME 83
Cdd:cd00115     2 ILFICTGNICRSPMAEAIFKQLlGDEWKVDSAGTGAHHGEGADPRAVRVLKEVGIDIS-HRSDQIKSEHLDNYDLVLVMD 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1314859998  84 KRHIERLCEMAPEMRGKVMLFGHWDNECEIPDPYRKSRETFAAVYTLLERSARQWAQ 140
Cdd:cd00115    81 GSNLDKIPRIFPEARGKTWLPHVKLEHGEIDDPYRGDIEDFRRVRDELENASKRFAE 137
LMWPAP cd16344
low molecular weight protein arginine phosphatase; Low molecular weight protein arginine ...
 4-133 1.01e-33

low molecular weight protein arginine phosphatase; Low molecular weight protein arginine phosphatases are part of the low molecular weight phosphatase (LMWP) family. They share a highly conserved active site motif (V/I)CXGNTCRS. It has been shown that the conserved threonine, which in many LMWPTPs is an isoleucine, confers specificity to phosphoarginine over phosphotyrosine.


Pssm-ID: 319972  Cd Length: 142  Bit Score: 115.22  E-value: 1.01e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1314859998   4 NILVVCVGNICRSPTAERLLQRYHPELKVE--SAGLGALVGKGADPTAISVAAEHQLSLEGHCARQISRRLCRNYDLILT 81
Cdd:cd16344     2 KILFVCTGNTCRSPMAEAILKKLLEELDVEvkSAGIFAVDGSPASPNAVEVLKEKGIDLSGHRSQQLTEELLEWADLILT 81

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1314859998  82 MEKRHIERLCEMAPEMRGKVMLFGHW--DNECEIPDPYRKSRETFAAVYTLLER 133
Cdd:cd16344    82 MTESHKQALLSLYPEAADKVFTLKEYvgGEDGDISDPFGGSLEVYRQTAEELEE 135
LMWP_ArsC cd16345
Arsenate reductase of the LMWP family; Arsenate reductase plays an important role in the ...
 4-133 5.24e-11

Arsenate reductase of the LMWP family; Arsenate reductase plays an important role in the reduction of intracellular arsenate to arsenite, an important step in arsenic detoxification. The reduction involves three different thiolate nucleophiles. In arsenate reductases of the LMWP family, reduction can be coupled with thioredoxin (Trx)/thioredoxin reductase (TrxR) or glutathione (GSH)/glutaredoxin (Grx).


Pssm-ID: 319973  Cd Length: 132  Bit Score: 56.30  E-value: 5.24e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1314859998   4 NILVVCVGNICRSPTAERLLQRYHPE-LKVESAGLGAlvgKGADPTAISVAAEHQLSLEGHCARQISRRLCRNYDLILTM 82
Cdd:cd16345     1 KVLFLCTGNSARSQMAEALLRHLGGDrFEAYSAGSEP---AGVNPLAIEVMKEIGIDISGQRSKSLDEFLGQEFDYVITV 77

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1314859998  83 ekrhierlCEMAPE-----MRGKVMLfgHWDneceIPDPYRKS------RETFAAVYTLLER 133
Cdd:cd16345    78 --------CDNAAEvcpvfPGAVKRL--HWG----FPDPAAAEgseeekLEAFRRVRDEIKE 125
PRK13530 PRK13530
arsenate reductase (thioredoxin);
5-127 6.51e-06

arsenate reductase (thioredoxin);


Pssm-ID: 237415  Cd Length: 133  Bit Score: 42.81  E-value: 6.51e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1314859998   5 ILVVCVGNICRSPTAERLLQRY-HPELKVESAGLGAlvgKGADPTAISVAAEHQLSLEGHCARQISRRLCRNYDLILTME 83
Cdd:PRK13530    6 IYFLCTGNSCRSQMAEGWGKQYlGDKWNVYSAGIEA---HGVNPNAIKAMKEVGIDISNQTSDIIDNDILNNADLVVTLC 82

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1314859998  84 KrHIERLCEMAPEMRGKVmlfgHWDNEceipDPYRKSRETFAAV 127
Cdd:PRK13530   83 S-HADDVCPSTPPHVKRV----HWGFD----DPAGKEWSEFQRV 117
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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