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Conserved domains on  [gi|1314860065|gb|AUG16879|]
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ABC transporter substrate-binding protein [Escherichia coli str. K-12 substr. MG1655]

Protein Classification

ABC transporter substrate-binding protein( domain architecture ID 10194472)

ABC transporter substrate-binding protein similar to OsmF (YehZ), which is part of the YehZYXW complex, a non-osmoregulatory betaine-specific ABC transporter

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PBP2_OsmF cd13616
Substrate-binding domain OsmF of an osmoregulated ABC-type transporter; the type 2 ...
26-299 1.50e-178

Substrate-binding domain OsmF of an osmoregulated ABC-type transporter; the type 2 periplasmic-binding protein fold; Osmoprotectant binding lipoprotein OsmF of an ABC transporter (YehZYXW) from Escherichia coli is predicted to be involved in uptake of compatible solutes such as choline, L-proline and glycine betaine, but the relative substrate preference is not known. To counteract the efflux of water, microorganisms accumulate the compatible solutes for a sustained adjustment to high osmolarity surroundings. OsmF belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.


:

Pssm-ID: 270334  Cd Length: 274  Bit Score: 493.77  E-value: 1.50e-178
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1314860065  26 PVKVGSKIDTEGALLGNIILQVLESHGVPTVNKVQLGTTPVVRGAITSGELDIYPEYTGNGAFFFKDENDAAWKNAQQGY 105
Cdd:cd13616     1 PVVVGSKIDTEGALLGNMIVLALEAHGFPVEDKTGLGTTPVVRKALLSGEIDLYPEYTGNGAFFFPEADDPVWKDARKGY 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1314860065 106 EKVKKLDSEHNKLIWLTPAPANNTWTIAVRQDVAEKNKLTSLADLSRYLQEGGTFKLAASAEFIERADALPAFEKAYGFK 185
Cdd:cd13616    81 ETVKELDAKNNGLVWLDPAPANNTWAIAVRRDLAEKNNLKTLADLAAYVNEGGAFKLAASAEFVERPDALPAFEKAYGFK 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1314860065 186 LGQDQLLSLAGGDTAVTIKAAAQQTSGVNAAMAYGTDGPVAALGLQTLSDPQGVQPIYAPAPVVRESVLREYPQMAQWLQ 265
Cdd:cd13616   161 LSKDQLVILSGGNTAQTEQAAAQGTSGVNAAMAYGTDGAIAALGLVVLEDPKGAQPVYAPAPVVRQEVLEAYPEIAEILK 240
                         250       260       270
                  ....*....|....*....|....*....|....
gi 1314860065 266 PVFASLDAKTLQQLNASIAVEGLDAKKVAADYLK 299
Cdd:cd13616   241 PVFATLDLKTLQELNARIAVEGESAEDVARDYLK 274
 
Name Accession Description Interval E-value
PBP2_OsmF cd13616
Substrate-binding domain OsmF of an osmoregulated ABC-type transporter; the type 2 ...
26-299 1.50e-178

Substrate-binding domain OsmF of an osmoregulated ABC-type transporter; the type 2 periplasmic-binding protein fold; Osmoprotectant binding lipoprotein OsmF of an ABC transporter (YehZYXW) from Escherichia coli is predicted to be involved in uptake of compatible solutes such as choline, L-proline and glycine betaine, but the relative substrate preference is not known. To counteract the efflux of water, microorganisms accumulate the compatible solutes for a sustained adjustment to high osmolarity surroundings. OsmF belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.


Pssm-ID: 270334  Cd Length: 274  Bit Score: 493.77  E-value: 1.50e-178
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1314860065  26 PVKVGSKIDTEGALLGNIILQVLESHGVPTVNKVQLGTTPVVRGAITSGELDIYPEYTGNGAFFFKDENDAAWKNAQQGY 105
Cdd:cd13616     1 PVVVGSKIDTEGALLGNMIVLALEAHGFPVEDKTGLGTTPVVRKALLSGEIDLYPEYTGNGAFFFPEADDPVWKDARKGY 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1314860065 106 EKVKKLDSEHNKLIWLTPAPANNTWTIAVRQDVAEKNKLTSLADLSRYLQEGGTFKLAASAEFIERADALPAFEKAYGFK 185
Cdd:cd13616    81 ETVKELDAKNNGLVWLDPAPANNTWAIAVRRDLAEKNNLKTLADLAAYVNEGGAFKLAASAEFVERPDALPAFEKAYGFK 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1314860065 186 LGQDQLLSLAGGDTAVTIKAAAQQTSGVNAAMAYGTDGPVAALGLQTLSDPQGVQPIYAPAPVVRESVLREYPQMAQWLQ 265
Cdd:cd13616   161 LSKDQLVILSGGNTAQTEQAAAQGTSGVNAAMAYGTDGAIAALGLVVLEDPKGAQPVYAPAPVVRQEVLEAYPEIAEILK 240
                         250       260       270
                  ....*....|....*....|....*....|....
gi 1314860065 266 PVFASLDAKTLQQLNASIAVEGLDAKKVAADYLK 299
Cdd:cd13616   241 PVFATLDLKTLQELNARIAVEGESAEDVARDYLK 274
OsmF COG1732
Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system ...
3-301 3.85e-112

Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441338 [Multi-domain]  Cd Length: 294  Bit Score: 326.33  E-value: 3.85e-112
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1314860065   3 LLKLWAGSLVMLAAVSLPLQAAS--PVKVGSKIDTEGALLGNIILQVLESHGVPTVNKVQLGTTPVVRGAITSGELDIYP 80
Cdd:COG1732     6 LLALALAAALALAGCGLASAAAAgdTIVVGSKNFTEQEILAEIYAQALEAAGLKVERKLNLGGTEVVRQALKSGEIDLYP 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1314860065  81 EYTGNGAFFFKDENDAawKNAQQGYEKVKKLDSEHNKLIWLTPAPANNTWTIAVRQDVAEKNKLTSLADLSRYLqegGTF 160
Cdd:COG1732    86 EYTGTALTTYLKEDPI--TDPEEVYEAVKEALPEKNGLTWLDPAGFNNTYALAVTKETAEKYGLKTISDLAKVA---GEL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1314860065 161 KLAASAEFIERADALPAFEKAYGFKLGQdqLLSLAGGdtavtIKAAAQQTSGVNAAMAYGTDGPVAALGLQTLSDPQGVQ 240
Cdd:COG1732   161 TLGADPEFAERPDGLPGLKKAYGFEFKE--VKPMDTG-----LTYTALANGQVDVADAYTTDGRIAALDLVVLEDDKNFF 233
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1314860065 241 PIYAPAPVVRESVLREYPQMAQWLQPVFASLDAKTLQQLNASIAVEGLDAKKVAADYLKQK 301
Cdd:COG1732   234 PPYNAAPLVRKEVLEKYPELAEVLNKLSGKLTTETMQELNYQVDVDGEDPADVAREFLKEK 294
OpuAC pfam04069
Substrate binding domain of ABC-type glycine betaine transport system; Part of a high affinity ...
26-300 1.59e-56

Substrate binding domain of ABC-type glycine betaine transport system; Part of a high affinity multicomponent binding-protein-dependent transport system involved in bacterial osmoregulation. This domain is often fused to the permease component of the transporter complex. Family members are often integral membrane proteins or predicted to be attached to the membrane by a lipid anchor. Glycine betaine is involved in protection from high osmolarity environments for example in Bacillus subtilis. The family member OpuBC is closely related, and involved in choline transport. Choline is necessary for the biosynthesis of glycine betaine. L-carnitine is important for osmoregulation in Listeria monocytogenes. Family also contains proteins binding l-proline (ProX), histidine (HisX) and taurine (TauA).


Pssm-ID: 397954 [Multi-domain]  Cd Length: 257  Bit Score: 182.91  E-value: 1.59e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1314860065  26 PVKVGSKIDTEGALLGNIILQVLESHGVpTVNKVQLGTTPVVRGAITSGELDIYP-EYTGNGafffkdendaawknaqqg 104
Cdd:pfam04069   2 TIVIGSKNWTEQEILANIAAQLLEALGY-VVELVGLGSSAVLFAALASGDIDLYPeEWTGTT------------------ 62
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1314860065 105 YEKVKKLDSEHNKLIWLTPAPANNTWTIAVRQDVAEKNKLTSLADLSRYlqeGGTFKLAASAEFIERADALP------AF 178
Cdd:pfam04069  63 YEAYKKAVEEKLGLLVLGPLGAGNTYGLAVPKYVAEKPGIKSISDLAKP---ADDLELGFKGEFIGRPDGWGcmrsteGL 139
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1314860065 179 EKAYGFKLGQDQLLSLAGGDTAvtIKAAAQQTSgVNAAMAYGTDGPVAALGLQTLSDPQGVQ-PIYAPAPVVRESVLREY 257
Cdd:pfam04069 140 LKAYGLDKYELVEGSEAAMDAL--IYAAYKRGE-PDVVYAWTPDWMIKKYDLVVLEDPKGLFpPAYNVVPVVRKGFAEKH 216
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 1314860065 258 PQMAQWLQPVfaSLDAKTLQQLNASIAVEGLDAKKVAADYLKQ 300
Cdd:pfam04069 217 PEVAAFLNKL--SLDTEDLNELNAQVDVEGKDPEEVAKDWLAE 257
 
Name Accession Description Interval E-value
PBP2_OsmF cd13616
Substrate-binding domain OsmF of an osmoregulated ABC-type transporter; the type 2 ...
26-299 1.50e-178

Substrate-binding domain OsmF of an osmoregulated ABC-type transporter; the type 2 periplasmic-binding protein fold; Osmoprotectant binding lipoprotein OsmF of an ABC transporter (YehZYXW) from Escherichia coli is predicted to be involved in uptake of compatible solutes such as choline, L-proline and glycine betaine, but the relative substrate preference is not known. To counteract the efflux of water, microorganisms accumulate the compatible solutes for a sustained adjustment to high osmolarity surroundings. OsmF belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.


Pssm-ID: 270334  Cd Length: 274  Bit Score: 493.77  E-value: 1.50e-178
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1314860065  26 PVKVGSKIDTEGALLGNIILQVLESHGVPTVNKVQLGTTPVVRGAITSGELDIYPEYTGNGAFFFKDENDAAWKNAQQGY 105
Cdd:cd13616     1 PVVVGSKIDTEGALLGNMIVLALEAHGFPVEDKTGLGTTPVVRKALLSGEIDLYPEYTGNGAFFFPEADDPVWKDARKGY 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1314860065 106 EKVKKLDSEHNKLIWLTPAPANNTWTIAVRQDVAEKNKLTSLADLSRYLQEGGTFKLAASAEFIERADALPAFEKAYGFK 185
Cdd:cd13616    81 ETVKELDAKNNGLVWLDPAPANNTWAIAVRRDLAEKNNLKTLADLAAYVNEGGAFKLAASAEFVERPDALPAFEKAYGFK 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1314860065 186 LGQDQLLSLAGGDTAVTIKAAAQQTSGVNAAMAYGTDGPVAALGLQTLSDPQGVQPIYAPAPVVRESVLREYPQMAQWLQ 265
Cdd:cd13616   161 LSKDQLVILSGGNTAQTEQAAAQGTSGVNAAMAYGTDGAIAALGLVVLEDPKGAQPVYAPAPVVRQEVLEAYPEIAEILK 240
                         250       260       270
                  ....*....|....*....|....*....|....
gi 1314860065 266 PVFASLDAKTLQQLNASIAVEGLDAKKVAADYLK 299
Cdd:cd13616   241 PVFATLDLKTLQELNARIAVEGESAEDVARDYLK 274
OsmF COG1732
Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system ...
3-301 3.85e-112

Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 441338 [Multi-domain]  Cd Length: 294  Bit Score: 326.33  E-value: 3.85e-112
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1314860065   3 LLKLWAGSLVMLAAVSLPLQAAS--PVKVGSKIDTEGALLGNIILQVLESHGVPTVNKVQLGTTPVVRGAITSGELDIYP 80
Cdd:COG1732     6 LLALALAAALALAGCGLASAAAAgdTIVVGSKNFTEQEILAEIYAQALEAAGLKVERKLNLGGTEVVRQALKSGEIDLYP 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1314860065  81 EYTGNGAFFFKDENDAawKNAQQGYEKVKKLDSEHNKLIWLTPAPANNTWTIAVRQDVAEKNKLTSLADLSRYLqegGTF 160
Cdd:COG1732    86 EYTGTALTTYLKEDPI--TDPEEVYEAVKEALPEKNGLTWLDPAGFNNTYALAVTKETAEKYGLKTISDLAKVA---GEL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1314860065 161 KLAASAEFIERADALPAFEKAYGFKLGQdqLLSLAGGdtavtIKAAAQQTSGVNAAMAYGTDGPVAALGLQTLSDPQGVQ 240
Cdd:COG1732   161 TLGADPEFAERPDGLPGLKKAYGFEFKE--VKPMDTG-----LTYTALANGQVDVADAYTTDGRIAALDLVVLEDDKNFF 233
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1314860065 241 PIYAPAPVVRESVLREYPQMAQWLQPVFASLDAKTLQQLNASIAVEGLDAKKVAADYLKQK 301
Cdd:COG1732   234 PPYNAAPLVRKEVLEKYPELAEVLNKLSGKLTTETMQELNYQVDVDGEDPADVAREFLKEK 294
PBP2_osmoprotectants cd13528
Substrate-binding domain of osmoregulatory ABC-type transporters; the type 2 ...
26-299 1.34e-99

Substrate-binding domain of osmoregulatory ABC-type transporters; the type 2 periplasmic-binding protein fold; This family represents the periplasmic substrate-binding component of ABC transport systems that are involved in uptake of osmoprotectants (also termed compatible solutes) such as betaine, choline, proline betaine, carnitine, and L-proline. To counteract the efflux of water, bacteria and archaea accumulate the compatible solutes for a sustained adjustment to high osmolarity surroundings. This substrate-binding domain belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.


Pssm-ID: 270246 [Multi-domain]  Cd Length: 264  Bit Score: 293.35  E-value: 1.34e-99
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1314860065  26 PVKVGSKIDTEGALLGNIILQVLESHGVPTVN-KVQLGTTPVVRGAITSGELDIYPEYTGNGAFFFKDEnDAAWKNAQQG 104
Cdd:cd13528     1 TIVVGSKNFTEQYILGEMLAQLLEANTDLTVErKLNLGGTEVAFNALKNGDIDLYVEYTGTALLTILKE-DAPITDPEEV 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1314860065 105 YEKVKKLDSEHNKLIWLTPAPANNTWTIAVRQDVAEKNKLTSLADLSRYlqeGGTFKLAASAEFIERADALPAFEKAYGF 184
Cdd:cd13528    80 YEKVKKEYEEKFGLTWLDPLGFNNTYALAVRKDTAEKYGLKTISDLAPH---SDQLVFGADPEFYERSDGLPGLKKTYGF 156
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1314860065 185 KLGQDQLLslaggDTAVTIKAAAQQTsgVNAAMAYGTDGPVAALGLQTLSDPQGVQPIYAPAPVVRESVLREYPQMAQWL 264
Cdd:cd13528   157 DFKEVKTM-----DPGLTYEALDNGE--VDVIDAFSTDGRIKAFDLVVLEDDKNFFPPYNAAPVVREDVLKKHPELEEVL 229
                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1314860065 265 QPVFASLDAKTLQQLNASIAVEGLDAKKVAADYLK 299
Cdd:cd13528   230 NKLSGKLTDETMQQLNYQVDVEGKDPEEVARDFLK 264
PBP2_YehZ cd13611
Substrate-binding domain YehZ of an osmoregulated ABC-type transporter; the type 2 ...
26-299 4.51e-79

Substrate-binding domain YehZ of an osmoregulated ABC-type transporter; the type 2 periplasmic-binding protein fold; Osmoprotectant binding lipoprotein YehZ of Clostridium sticklandii is predicted to be involved in uptake of compatible solutes such as choline, L-proline and glycine betaine, but the relative substrate preference is not known. To counteract the efflux of water, microorganisms accumulate the compatible solutes for a sustained adjustment to high osmolarity surroundings. YehZ belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.


Pssm-ID: 270329  Cd Length: 267  Bit Score: 240.95  E-value: 4.51e-79
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1314860065  26 PVKVGSKIDTEGALLGNIILQVLESHGVPTVNKVQLGTTPVVRGAITSGELDIYPEYTGNGAFFFKDENDAAwKNAQQGY 105
Cdd:cd13611     1 TITVGSKDFTEQLILGKITVQALQAAGADVTDKTNLGGSASARQALENGQVDVYWEYTGTAWITYLGHTEPI-LDPQEQY 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1314860065 106 EKVKKLDSEhNKLIWLTPAPANNTWTIAVRQDVAEKNKLTSLADLSRYLQEGGTFKLAASAEFIERADALPAFEKAYGFK 185
Cdd:cd13611    80 EAVKDLDAE-KGLVWLDPAPLNNTYALAMREATAEELGITTLSDLALAKLPPGDRTFCVDAEFASRPDGLPPLLEAYGFE 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1314860065 186 LGQDQLLSLaggDTAVTIKAAAQQTsgVNAAMAYGTDGPVAALGLQTLSDPQGVQPIYAPAPVVRESVLREYPQMAQWLQ 265
Cdd:cd13611   159 FPRANVRQM---DTGLVYTATANGQ--CDFGEVFTTDGRIKALDLVVLEDDKGFFPAYNAAPVVRTEVLDAHPELAEILN 233
                         250       260       270
                  ....*....|....*....|....*....|....
gi 1314860065 266 PVFASLDAKTLQQLNASIAVEGLDAKKVAADYLK 299
Cdd:cd13611   234 PISAKLDNDTMQELNARVDVDGEDPADVARDWLV 267
PBP2_QAT_like cd13614
Substrate-binding domain of quaternary amine ABC-type transporter; the type 2 ...
26-299 3.35e-64

Substrate-binding domain of quaternary amine ABC-type transporter; the type 2 periplasmic-binding protein fold; This group includes the periplasmic substrate-binding component of a putative quaternary amine ABC transport system that is predicted to be involved in uptake of osmoprotectants (also termed compatible solutes) such as betaine, choline, proline betaine, carnitine, and L-proline. The relative substrate preference of this group is not known. To counteract the efflux of water, many microorganisms accumulate the compatible solutes for a sustained adjustment to high osmolarity surroundings. This substrate-binding domain belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.


Pssm-ID: 270332  Cd Length: 264  Bit Score: 203.00  E-value: 3.35e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1314860065  26 PVKVGSKIDTEGALLGNIILQVLESHGVPTVNKVQLGTTPVVRGAITSGELDIYPEYTGNG-AFFFKDENDAawkNAQQG 104
Cdd:cd13614     1 AIRVGSKNFTEQFILGEMYALALEDAGIKVERKLNLGGTLIAHQALVNGEIDLYPEYTGTAlLTVLKGEPSS---DAKQV 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1314860065 105 YEKVKKLDSEHNKLIWLTPAPANNTWTIAVRQDVAEKNKLTSLADLSRylqEGGTFKLAASAEFIERADALPAFEKAYG- 183
Cdd:cd13614    78 YKTVKDAYAEQFQLTWLEPAPFNNTYALVMTRETAEKYGIKTLSDLAK---AAGELVFGGGPEFQDREDGLPGLKAKYGa 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1314860065 184 FKLGQDQLLSLAGgdtaVTIKAAAQQTSGVnaAMAYGTDGPVAALGLQTLSDPQGVQPIYAPAPVVRESVLREYPQMAQW 263
Cdd:cd13614   155 FDFKEFVQVDPLG----LRYQALAQGQIDV--AVGFGTDGQIAAYGLVVLEDDKNLFPPYQVAPVVRQDVLDANPKIAEV 228
                         250       260       270
                  ....*....|....*....|....*....|....*.
gi 1314860065 264 LQPVFASLDAKTLQQLNASIAVEGLDAKKVAADYLK 299
Cdd:cd13614   229 LNKLSALLDNETMQRLNYEVDGNKREPKDVAREFLK 264
OpuAC pfam04069
Substrate binding domain of ABC-type glycine betaine transport system; Part of a high affinity ...
26-300 1.59e-56

Substrate binding domain of ABC-type glycine betaine transport system; Part of a high affinity multicomponent binding-protein-dependent transport system involved in bacterial osmoregulation. This domain is often fused to the permease component of the transporter complex. Family members are often integral membrane proteins or predicted to be attached to the membrane by a lipid anchor. Glycine betaine is involved in protection from high osmolarity environments for example in Bacillus subtilis. The family member OpuBC is closely related, and involved in choline transport. Choline is necessary for the biosynthesis of glycine betaine. L-carnitine is important for osmoregulation in Listeria monocytogenes. Family also contains proteins binding l-proline (ProX), histidine (HisX) and taurine (TauA).


Pssm-ID: 397954 [Multi-domain]  Cd Length: 257  Bit Score: 182.91  E-value: 1.59e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1314860065  26 PVKVGSKIDTEGALLGNIILQVLESHGVpTVNKVQLGTTPVVRGAITSGELDIYP-EYTGNGafffkdendaawknaqqg 104
Cdd:pfam04069   2 TIVIGSKNWTEQEILANIAAQLLEALGY-VVELVGLGSSAVLFAALASGDIDLYPeEWTGTT------------------ 62
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1314860065 105 YEKVKKLDSEHNKLIWLTPAPANNTWTIAVRQDVAEKNKLTSLADLSRYlqeGGTFKLAASAEFIERADALP------AF 178
Cdd:pfam04069  63 YEAYKKAVEEKLGLLVLGPLGAGNTYGLAVPKYVAEKPGIKSISDLAKP---ADDLELGFKGEFIGRPDGWGcmrsteGL 139
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1314860065 179 EKAYGFKLGQDQLLSLAGGDTAvtIKAAAQQTSgVNAAMAYGTDGPVAALGLQTLSDPQGVQ-PIYAPAPVVRESVLREY 257
Cdd:pfam04069 140 LKAYGLDKYELVEGSEAAMDAL--IYAAYKRGE-PDVVYAWTPDWMIKKYDLVVLEDPKGLFpPAYNVVPVVRKGFAEKH 216
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 1314860065 258 PQMAQWLQPVfaSLDAKTLQQLNASIAVEGLDAKKVAADYLKQ 300
Cdd:pfam04069 217 PEVAAFLNKL--SLDTEDLNELNAQVDVEGKDPEEVAKDWLAE 257
PBP2_ProWY cd13615
Substrate-binding domain of ABC-type osmoregulated transporter; the type 2 periplasmic-binding ...
26-299 2.39e-53

Substrate-binding domain of ABC-type osmoregulated transporter; the type 2 periplasmic-binding protein fold; Osmoprotectant binding lipoprotein ProWY of Streptococcus thermophilus is predicted to be involved in uptake of compatible solutes such as choline, L-proline and glycine betaine, but the relative substrate preference is not known. To counteract the efflux of water, microorganisms accumulate the compatible solutes for a sustained adjustment to high osmolarity surroundings. ProWY belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.


Pssm-ID: 270333  Cd Length: 262  Bit Score: 174.94  E-value: 2.39e-53
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1314860065  26 PVKVGSKIDTEGALLGNIILQVLESHGVPTVNKVQLGTTpVVRGAITSGELDIYPEYTGNGAFFFKDEndAAWKNAQQGY 105
Cdd:cd13615     1 AIRVGSKDFTENLIVAEIYALALEDAGYKVKRKPNISSS-VVHQALTSGQIDLYPEYTGTGLLAVLKK--EAITDPQKVY 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1314860065 106 EKVKKLDSEHNKLIWLTPAPANNTWTIAVRQDVAEKNKLTSLADLSRYLQEggtFKLAASAEFIERADALPAFEKAYG-- 183
Cdd:cd13615    78 ATVKDGYAKKFNLVWLDYAPANDGQGLVIRTSVAKKYGIKTISDLQKNASQ---IRFASQGEFDQREDGLPGLEKVYGkf 154
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1314860065 184 -FKLGQDQllslaggDTAVTIKAAAQQTSgvNAAMAYGTDGPVAALGLQTLSDPQGVQPIYAPAPVVRESVLREYPQMAQ 262
Cdd:cd13615   155 sFKSTKVY-------DNGLKYQVLANDKA--DITPAYTTEGQLDTSKFTLLKDDKHVWPPYNLAPVVRKDVLKANPKIAS 225
                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1314860065 263 WLQPVFASLDAKTLQQLNASIAVEGLDAKKVAADYLK 299
Cdd:cd13615   226 ALNKVSAKLTTKTLTQLNAKVDVDKQEYADVAKDFYL 262
PBP2_Opu_like_1 cd13609
Substrate-binding domain of putative ABC-type osmoprotectant uptake system; the type 2 ...
27-299 1.21e-52

Substrate-binding domain of putative ABC-type osmoprotectant uptake system; the type 2 periplasmic-binding protein fold; This group includes the periplasmic substrate-binding component of a putative ABC transport system that is predicted to be involved in uptake of osmoprotectants (also termed compatible solutes) such as betaine, choline, proline betaine, carnitine, and L-proline. The relative substrate preference of this group is not known. To counteract the efflux of water, many microorganisms accumulate the compatible solutes for a sustained adjustment to high osmolarity surroundings. This substrate-binding domain belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.


Pssm-ID: 270327  Cd Length: 263  Bit Score: 173.17  E-value: 1.21e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1314860065  27 VKVGSKIDTEGALLGNIILQVLESHGVPTVN-KVQLGTTPVVRGAITSGELDIYPEYTGNG-AFFFKDENDaawKNAQQG 104
Cdd:cd13609     2 IVIGSKNFTEQLILGNMYADLIEANTDIKVErKLNLGGSSVCFSALKNGDIDMYVDYTGTIlVNILKEPPI---SDPDEV 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1314860065 105 YEKVKKLDSEHNKLIWLTPAPANNTWTIAVRQDVAEKNKLTSLADLSRYlqeGGTFKLAASAEFIERADALPAFEKAYGF 184
Cdd:cd13609    79 YNTVKELMKEKYNLEVLKPLGFNNTYTLAVRKETAEKYNLKTISDLAKV---SDELTLGCTLEFLNREDGLPGLEKTYGL 155
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1314860065 185 KLGQdqLLSLAGGdtavtIKAAAQQTSGVNAAMAYGTDGPVAALGLQTLSDPQGVQPIYAPAPVVRESVLREYPQmaqwL 264
Cdd:cd13609   156 NFKD--VKGLDGS-----LRYTALENGEVDVIDAFSTDGLLKKFDLVVLEDDKNFFPPYYAVPLVREETLEKYPE----L 224
                         250       260       270
                  ....*....|....*....|....*....|....*....
gi 1314860065 265 QPVFASLDAK----TLQQLNASIAVEGLDAKKVAADYLK 299
Cdd:cd13609   225 EDVLNKLAGKiseeTMRELNYKVDELGKDPEDVAHEFLV 263
PBP2_Opu_like_2 cd13613
Substrate-binding domain of putative ABC-type osmoprotectant uptake system; the type 2 ...
26-299 2.40e-49

Substrate-binding domain of putative ABC-type osmoprotectant uptake system; the type 2 periplasmic-binding protein fold; This group includes the periplasmic substrate-binding component of a putative ABC transport system that is predicted to be involved in uptake of osmoprotectants (also termed compatible solutes) such as betaine, choline, proline betaine, carnitine, and L-proline. The relative substrate preference of this group is not known. To counteract the efflux of water, many microorganisms accumulate the compatible solutes for a sustained adjustment to high osmolarity surroundings. This substrate-binding domain belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.


Pssm-ID: 270331  Cd Length: 264  Bit Score: 164.82  E-value: 2.40e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1314860065  26 PVKVGSKIDTEGALLGNIILQVLESHGVPTVN-KVQLGTTPVVRGAITSGELDIYPEYTGNG--AFFFKDENdaawKNAQ 102
Cdd:cd13613     1 RIIIGSKNFTEQVILGELLAQQIEARTDLKVErRFNLGGTFICHQALLSGAIDAYVEYTGTAltAILKQPPI----RDPQ 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1314860065 103 QGYEKVKKLDSEHNKLIWLTPAPANNTWTIAVRQDVAEKNKLTSLADLSRYLQeggTFKLAASAEFIERADALPAFEKAY 182
Cdd:cd13613    77 RVYEQVKQLYADRFGLEVMPPLGFENTFAILVRGEDARKLGLKTLSDAAPYTP---GWRAGFGYEFLERADGYPGLAKTY 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1314860065 183 GFKLGQD-QLLslaggDTAVTIKAAAQQTsgVNAAMAYGTDGPVAALGLQTLSDPQGVQPIYAPAPVVRESVLREYPQma 261
Cdd:cd13613   154 GLKFAKTpRVM-----DLGLLYRALAQKQ--VDLIAGNSTDGLIAALDLVILEDDRHYFPPYQAVPVVRQATLAKYPE-- 224
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1314860065 262 qwLQPVFASLDAK----TLQQLNASIAVEGLDAKKVAADYLK 299
Cdd:cd13613   225 --LRTAIAELAGKisaeTMQQMNYQVDGEHRDVAEVAREFLK 264
PBP2_ProWX cd13612
Substrate-binding protein ProWX of ABC-type osmoregulated transporter and its related proteins; ...
26-302 4.20e-44

Substrate-binding protein ProWX of ABC-type osmoregulated transporter and its related proteins; the type 2 periplasmic-binding protein fold; Osmoprotectant binding lipoprotein ProWX of Helicobacter pylori is predicted to be involved in uptake of compatible solutes such as choline, L-proline and glycine betaine, but the relative substrate preference is not known. To counteract the efflux of water, microorganisms accumulate the compatible solutes for a sustained adjustment to high osmolarity surroundings. ProWX belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.


Pssm-ID: 270330  Cd Length: 267  Bit Score: 151.24  E-value: 4.20e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1314860065  26 PVKVGSKIDTEGALLGNIILQVLESHGVPTVNKVQL--GTTPVVRGAITSGELDIYPEYTGNG-AFFFKDEN---DAAWK 99
Cdd:cd13612     1 TIHIATKPMTEQYILGEMLKQLIEQDTDLKVELTKGvgGGTSNIHPAMVKGEFDLYPEYTGTGwLFVLKKDGtysEELFD 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1314860065 100 NAQQGYEKvkkldsEHNkLIWLTPAPANNTWTIAVRQDVAEKNKLTSLADLSRYlqeGGTFKLAASAEFIERADALPAFE 179
Cdd:cd13612    81 QLQKEYEE------KYN-LTWLGLYGFNNTYGLAVRKELAEKYNLKTYSDLAKV---SNQLVFGAEYDFFEREDGYDALQ 150
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1314860065 180 KAYGFKLGQDQllslaggDTAVTIKAAAQQTSGVNAAMAYGTDGPVAALGLQTLSDPQGVQPIYAPAPVVRESVLREYPQ 259
Cdd:cd13612   151 KAYGFNFKKTV-------DMDIGLKYQAIESGKVDVINVFTTDGQLSDADIVVLEDDKGFFPSYYAGTVVREETLEKYPE 223
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|...
gi 1314860065 260 MAQWLQPVFASLDAKTLQQLNASIAVEGLDAKKVAADYLKQKG 302
Cdd:cd13612   224 LEDVLEKLTGLISDEDMAEMNYQVEIEKKDPKDVAKEFLEEKG 266
PBP2_AfProX_like cd13607
Substrate-binding protein ProX of ABC-type osmoregulatory transporter from Archaeoglobus ...
26-299 1.90e-43

Substrate-binding protein ProX of ABC-type osmoregulatory transporter from Archaeoglobus fulgidus and its related proteins; the type 2 periplasmic-binding protein fold; This subfamily includes the periplasmic substrate-binding protein ProX from the hyperthermophilic archaeon Archaeoglobus fulgidus and its related proteins. AfProX is involved in uptake of compatible solutes such as the trimethylammonium compound glycine betaine and the dimethylammonium compound proline betaine, but the relative substrate preference is not known. To counteract the efflux of water, many microorganisms accumulate the compatible solutes for a sustained adjustment to high osmolarity surroundings. AfProX belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.


Pssm-ID: 270325  Cd Length: 261  Bit Score: 149.27  E-value: 1.90e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1314860065  26 PVKVGSKIDTEGALLGNIILQVLESHGVPTVNKVQLGTTPVVRGAITSGELDIYPEYTG---NGAFFFKDENDAAwknaq 102
Cdd:cd13607     1 TVVIGSKTFTEQYILAEMIAQLLEEAGYPAEHREGLGGTRVLFEALKSGEIDVYVEYTGtlyAEILKRPETWDPA----- 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1314860065 103 QGYEKVKKLDSEHNKLIwLTPAPANNTWTIAVRQDVAEKNKLTSLADLSRYLQEggtFKLAASAEFIERADALPAFEKAY 182
Cdd:cd13607    76 AVLAELKEALAERGIVV-AGPLGFENTYALAMREDRAEALGIRTISDLLARAPD---LRFGFDPEFLDRPDGWPALRRVY 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1314860065 183 GfkLGQDQLLSLaggDTAVTIKAAAQQTsgVNAAMAYGTDGPVAALGLQTLSDPQGVQPIYAPAPVVRESVLREYPQMAQ 262
Cdd:cd13607   152 G--LPFKEVRGL---DHTLAYRALKSGQ--VDVIDAYTTDARIDAYDLRVLEDDRGAFPPYDAVLLYRADLAERAPKAVA 224
                         250       260       270
                  ....*....|....*....|....*....|....*..
gi 1314860065 263 WLQPVFASLDAKTLQQLNASIAVEGLDAKKVAADYLK 299
Cdd:cd13607   225 ALRRLEGRIDADTMRALNAQVDLEKRSEAEVAAEFLA 261
PBP2_ChoS cd13610
Substrate-binding domain ChoS of an osmoregulated ABC-type transporter and related proteins; ...
29-299 6.55e-40

Substrate-binding domain ChoS of an osmoregulated ABC-type transporter and related proteins; type 2 periplasmic-binding protein fold; Osmoprotectant binding lipoprotein ChoS of Lactococcus lactis is predicted to be involved in uptake of compatible solutes such as choline and glycine betaine, but the relative substrate preference is not known. To counteract the efflux of water, microorganisms accumulate the compatible solutes for a sustained adjustment to high osmolarity surroundings. ChoS belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.


Pssm-ID: 270328  Cd Length: 264  Bit Score: 140.42  E-value: 6.55e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1314860065  29 VGSKIDTEGALLGNIILQVLESHGVP-TVN-KVQLGTTPVVRGAITSGELDIYPEYTGnGAFFFKDENDAAWKNAQQGYE 106
Cdd:cd13610     4 IAGKLGSEPDILINMYKLLIEEETPDlQVTlKPNFGKTSFLFNALKSGDIDIYPEFTG-TVLETLLKEPPKSNDPMEVYE 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1314860065 107 KVKKLDSEHNKLIWLTPAPANNTWTIAVRQDVAEKNKLTSLADLSRYLQEggtFKLAASAEFIERADALPAFEKAYGFKL 186
Cdd:cd13610    83 QARDGLAKQYQLTYLKPMAYNNTYALAVKKEFAKQHNLKTISDLQKVQDK---LKAGFTLEFMDREDGYKGLQKAYGLNF 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1314860065 187 gqdQLLSLaggDTAVTIKAAAQQTsgVNAAMAYGTDGPVAALGLQTLSDPQGVQPIYAPAPVVRESVLREYPQMAQWLQP 266
Cdd:cd13610   160 ---NVKSM---EPALRYQAINNGQ--VNVIDAYSTDSEIKQYDLVVLKDDKHLFPPYQGAPLMREEFLKKHPELVKALNK 231
                         250       260       270
                  ....*....|....*....|....*....|...
gi 1314860065 267 VFASLDAKTLQQLNASIAVEGLDAKKVAADYLK 299
Cdd:cd13610   232 LAGKITDEEMQEMNYRVDVKHKSAAKVAKEYLQ 264
PBP2_OpuCC_like cd13608
Substrate-binding protein OpuCC of ABC-type osmoregulatory transporter and related proteins; ...
26-299 3.63e-38

Substrate-binding protein OpuCC of ABC-type osmoregulatory transporter and related proteins; the type 2 periplasmic-binding protein fold; This subfamily includes the periplasmic substrate-binding protein OpuCC of the ABC transporter OpuC (where Opu is osmoprotectant uptake), which can recognize a broad spectrum of compatible solutes, and its paralog OpuBC that can solely bind choline. To counteract the efflux of water, many microorganisms accumulate the compatible solutes for a sustained adjustment to high osmolarity surroundings. This substrate-binding domain belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.


Pssm-ID: 270326  Cd Length: 265  Bit Score: 135.83  E-value: 3.63e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1314860065  26 PVKVGSKIDTEGALLGNIILQVLESHGVPTVNKV-QLGTTPVVRGAITSGELDI-YPEYTG---NGAFFFKDEND--AAW 98
Cdd:cd13608     1 TIRIGSQSTTESQILAEMVKQLIEHYTDLKVELInNLGSSTVQHQAMLNGDANIsAARYTGtdlTGELGMEPIKDpeKAL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1314860065  99 KNAQQGYEKvkKLDsehnkLIWLTPAPANNTWTIAVRQDVAEKNKLTSLADLSRYLQEggtFKLAASAEFIER-ADALPA 177
Cdd:cd13608    81 KVVQKEFQK--RFD-----QTWFDSYGFANTYAFMVTKEFAEKYNLKKVSDLKKVADN---LKLGVDTSWLNRkGDGYPG 150
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1314860065 178 FEKAYGFKLGQdqllsLAGGDTAVTIKAAAQQTsgVNAAMAYGTDGPVAALGLQTLSDPQGVQPIYAPAPVVRESVLREY 257
Cdd:cd13608   151 FKETYGFDFGT-----VYPMQIGLVYDAVASGK--MDVVLGYSTDGRIKSYDLVVLEDDKQFFPPYDASPVATNEILKKY 223
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|..
gi 1314860065 258 PQMAQWLQPVFASLDAKTLQQLNASIAVEGLDAKKVAADYLK 299
Cdd:cd13608   224 PELEEILEKLEGKISTETMQELNYQVDNDLKEPSVVAKEFLE 265
PBP2_ProX_like cd13606
Bacterial substrate-binding protein ProX of ABC-type osmoregulated transporter and its related ...
26-299 1.25e-36

Bacterial substrate-binding protein ProX of ABC-type osmoregulated transporter and its related proteins; the type 2 periplasmic-binding protein fold; This group includes periplasmic substrate-binding component of ABC transport systems from gram-negative and -positive bacteria that are involved in uptake of osmoprotectants (also termed compatible solutes) such as betaine, choline, proline betaine, carnitine, and L-proline. To counteract the efflux of water, many microorganisms accumulate the compatible solutes for a sustained adjustment to high osmolarity surroundings. This substrate-binding domain belongs to the type 2 periplasmic binding fold protein superfamily (PBP2). The PBP2 proteins are typically comprised of two globular subdomains connected by a flexible hinge and bind their ligand in the cleft between these domains in a manner resembling a Venus flytrap.


Pssm-ID: 270324  Cd Length: 260  Bit Score: 131.53  E-value: 1.25e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1314860065  26 PVKVGSKIDTEGALLGNIILQVLESHGVPTVNKVQLGTTPVVRGAITSGELDIYPEYTGNGAFFFKDENDAAwkNAQQGY 105
Cdd:cd13606     1 TVVVGSADFPESEILAEIYAQALEAAGVKVTRKLNIGSREVYLPALEDGSIDLVPEYTGNLLQYLDKDATAT--DPEEVY 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1314860065 106 EKVKKLDSEhnKLIWLTPAPANNTWTIAVRQDVAEKNKLTSLADLSRYlqeGGTFKLAASAEFIERADALPAFEKAYGFK 185
Cdd:cd13606    79 AALKAALPE--GLEVLDPSPAEDKDALVVTKETAEKYGLKSIADLAPV---AGELTLGGPPEFKTRPYGLPGLKEVYGVT 153
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1314860065 186 LGQDQLLSLAGgdtAVTIKAAAQQTsgVNAAMAYGTDGPVAALGLQTLSDPQGVQPIYAPAPVVRESVLReyPQMAQWLQ 265
Cdd:cd13606   154 FKEFKPLDAGG---PLTVKALKDGT--VQVANIFTTDPAIADNGLVVLEDPKNLFPAQNVVPLVRKAKLD--DKAADALN 226
                         250       260       270
                  ....*....|....*....|....*....|....
gi 1314860065 266 PVFASLDAKTLQQLNASIAVEGLDAKKVAADYLK 299
Cdd:cd13606   227 AVSAKLTTEDLTELNKQVVGDKADPADVAKEWLK 260
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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