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Conserved domains on  [gi|1314866290|gb|AUG23103|]
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two-component system response regulator [Burkholderia pseudomallei]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
BetR pfam08667
BetR domain; This family includes an N-terminal helix-turn-helix domain.
 37-179 6.86e-76

BetR domain; This family includes an N-terminal helix-turn-helix domain.


:

Pssm-ID: 400827  Cd Length: 148  Bit Score: 229.34  E-value: 6.86e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1314866290  37 NADLITATRVRDLLTRTGIAPRSHNTTIANILGLSFSVVTRKMKGQIPWNLSQLQDIASYFGVPPAILLD---DKGVPP- 112
Cdd:pfam08667   1 DAKLIFAVRVRQLLDRTGIAERQQTTWLRDILGLSFSQANRKLKGSIPWNLAQLAKVAKYFGCPAAYLLGlteNSGCNPg 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1314866290 113 HPGVDMHDATLVIEARRFRCRAAIATKASSQADSDFVALQWQDSWVVYEKKHAPEGRTYAVDMIELR 179
Cdd:pfam08667  81 IQTTLLCDALLAQEAMAVAARAWISCLADAQAAPQFVAWKEHGGWWVGGRTEAPEQRVYAVLRLEIR 147
OmpR COG0745
DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain ...
 188-315 1.62e-12

DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain [Signal transduction mechanisms, Transcription];


:

Pssm-ID: 440508 [Multi-domain]  Cd Length: 204  Bit Score: 65.36  E-value: 1.62e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1314866290 188 ARIAVVDDSPDVAETICEYFAEKGVAAIAYYDSVSFRKALEVEDFDGYILDWLLGEETAAPLVRGIRAsENADAPIFLLT 267
Cdd:COG0745     2 PRILVVEDDPDIRELLADALEREGYEVDTAADGEEALELLEEERPDLILLDLMLPGMDGLEVCRRLRA-RPSDIPIIMLT 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1314866290 268 GKistgeaseDEIADIVSSFNARCEE---KPVRLPILFAEVARALKIAYPP 315
Cdd:COG0745    81 AR--------DDEEDRVRGLEAGADDyltKPFDPEELLARIRALLRRRAAE 123
 
Name Accession Description Interval E-value
BetR pfam08667
BetR domain; This family includes an N-terminal helix-turn-helix domain.
 37-179 6.86e-76

BetR domain; This family includes an N-terminal helix-turn-helix domain.


Pssm-ID: 400827  Cd Length: 148  Bit Score: 229.34  E-value: 6.86e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1314866290  37 NADLITATRVRDLLTRTGIAPRSHNTTIANILGLSFSVVTRKMKGQIPWNLSQLQDIASYFGVPPAILLD---DKGVPP- 112
Cdd:pfam08667   1 DAKLIFAVRVRQLLDRTGIAERQQTTWLRDILGLSFSQANRKLKGSIPWNLAQLAKVAKYFGCPAAYLLGlteNSGCNPg 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1314866290 113 HPGVDMHDATLVIEARRFRCRAAIATKASSQADSDFVALQWQDSWVVYEKKHAPEGRTYAVDMIELR 179
Cdd:pfam08667  81 IQTTLLCDALLAQEAMAVAARAWISCLADAQAAPQFVAWKEHGGWWVGGRTEAPEQRVYAVLRLEIR 147
OmpR COG0745
DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain ...
 188-315 1.62e-12

DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain [Signal transduction mechanisms, Transcription];


Pssm-ID: 440508 [Multi-domain]  Cd Length: 204  Bit Score: 65.36  E-value: 1.62e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1314866290 188 ARIAVVDDSPDVAETICEYFAEKGVAAIAYYDSVSFRKALEVEDFDGYILDWLLGEETAAPLVRGIRAsENADAPIFLLT 267
Cdd:COG0745     2 PRILVVEDDPDIRELLADALEREGYEVDTAADGEEALELLEEERPDLILLDLMLPGMDGLEVCRRLRA-RPSDIPIIMLT 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1314866290 268 GKistgeaseDEIADIVSSFNARCEE---KPVRLPILFAEVARALKIAYPP 315
Cdd:COG0745    81 AR--------DDEEDRVRGLEAGADDyltKPFDPEELLARIRALLRRRAAE 123
REC_OmpR_PhoB cd17618
phosphoacceptor receiver (REC) domain of PhoB response regulator from the OmpR family; The ...
 188-289 1.63e-05

phosphoacceptor receiver (REC) domain of PhoB response regulator from the OmpR family; The transcription factor PhoB is a component of the PhoR/PhoB two-component system, a key regulatory protein network that facilitates response to inorganic phosphate (Pi) starvation conditions by turning on the phosphate (pho) regulon whose products are involved in phosphorus uptake and metabolism. PhoB is a member of the OmpR family of DNA-binding response regulators that contains REC and winged helix-turn-helix (wHTH) DNA-binding output effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381133 [Multi-domain]  Cd Length: 118  Bit Score: 43.39  E-value: 1.63e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1314866290 188 ARIAVVDDSPDVAETICEYFAEKGVAAIAYYDSVSFRKALEVEDFDGYILDWLLGEETAAPLVRGIRASEN-ADAPIFLL 266
Cdd:cd17618     1 RTILIVEDEPAIREMIAFNLERAGFDVVEAEDAESAVNLIVEPRPDLILLDWMLPGGSGIQFIRRLKRDEMtRDIPIIML 80

                          90       100
                  ....*....|....*....|...
gi 1314866290 267 TGKistgeASEDeiaDIVSSFNA 289
Cdd:cd17618    81 TAR-----GEEE---DKVRGLEA 95
ompR PRK09468
osmolarity response regulator; Provisional
 189-269 2.08e-05

osmolarity response regulator; Provisional


Pssm-ID: 181883 [Multi-domain]  Cd Length: 239  Bit Score: 44.96  E-value: 2.08e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1314866290 189 RIAVVDDSPDVAETICEYFAEKGVAAIAYYDSVSFRKALEVEDFDGYILDWLLGEETAAPLVRGIRASENaDAPIFLLTG 268
Cdd:PRK09468    7 KILVVDDDMRLRALLERYLTEQGFQVRSAANAEQMDRLLTRESFHLMVLDLMLPGEDGLSICRRLRSQNN-PTPIIMLTA 85


                  .
gi 1314866290 269 K 269
Cdd:PRK09468   86 K 86
Response_reg pfam00072
Response regulator receiver domain; This domain receives the signal from the sensor partner in ...
 190-269 1.56e-03

Response regulator receiver domain; This domain receives the signal from the sensor partner in bacterial two-component systems. It is usually found N-terminal to a DNA binding effector domain.


Pssm-ID: 395025 [Multi-domain]  Cd Length: 111  Bit Score: 37.52  E-value: 1.56e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1314866290 190 IAVVDDSPDVAETICEYFAEKGVAAIAYYDSVSFRKALEVEDFDGYILDWLLGEETAAPLVRGIRAsENADAPIFLLTGK 269
Cdd:pfam00072   1 VLIVDDDPLIRELLRQLLEKEGYVVAEADDGKEALELLKEERPDLILLDINMPGMDGLELLKRIRR-RDPTTPVIILTAH 79
 
Name Accession Description Interval E-value
BetR pfam08667
BetR domain; This family includes an N-terminal helix-turn-helix domain.
 37-179 6.86e-76

BetR domain; This family includes an N-terminal helix-turn-helix domain.


Pssm-ID: 400827  Cd Length: 148  Bit Score: 229.34  E-value: 6.86e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1314866290  37 NADLITATRVRDLLTRTGIAPRSHNTTIANILGLSFSVVTRKMKGQIPWNLSQLQDIASYFGVPPAILLD---DKGVPP- 112
Cdd:pfam08667   1 DAKLIFAVRVRQLLDRTGIAERQQTTWLRDILGLSFSQANRKLKGSIPWNLAQLAKVAKYFGCPAAYLLGlteNSGCNPg 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1314866290 113 HPGVDMHDATLVIEARRFRCRAAIATKASSQADSDFVALQWQDSWVVYEKKHAPEGRTYAVDMIELR 179
Cdd:pfam08667  81 IQTTLLCDALLAQEAMAVAARAWISCLADAQAAPQFVAWKEHGGWWVGGRTEAPEQRVYAVLRLEIR 147
OmpR COG0745
DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain ...
 188-315 1.62e-12

DNA-binding response regulator, OmpR family, contains REC and winged-helix (wHTH) domain [Signal transduction mechanisms, Transcription];


Pssm-ID: 440508 [Multi-domain]  Cd Length: 204  Bit Score: 65.36  E-value: 1.62e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1314866290 188 ARIAVVDDSPDVAETICEYFAEKGVAAIAYYDSVSFRKALEVEDFDGYILDWLLGEETAAPLVRGIRAsENADAPIFLLT 267
Cdd:COG0745     2 PRILVVEDDPDIRELLADALEREGYEVDTAADGEEALELLEEERPDLILLDLMLPGMDGLEVCRRLRA-RPSDIPIIMLT 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1314866290 268 GKistgeaseDEIADIVSSFNARCEE---KPVRLPILFAEVARALKIAYPP 315
Cdd:COG0745    81 AR--------DDEEDRVRGLEAGADDyltKPFDPEELLARIRALLRRRAAE 123
CheY COG0784
CheY-like REC (receiver) domain, includes chemotaxis protein CheY and sporulation regulator ...
 188-310 7.31e-09

CheY-like REC (receiver) domain, includes chemotaxis protein CheY and sporulation regulator Spo0F [Signal transduction mechanisms];


Pssm-ID: 440547 [Multi-domain]  Cd Length: 128  Bit Score: 53.32  E-value: 7.31e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1314866290 188 ARIAVVDDSPDVAETICEYFAEKGVAAIAYYDSVSFRKALEVEDFDGYILDWLLGEETAAPLVRGIRASE-NADAPIFLL 266
Cdd:COG0784     6 KRILVVDDNPDNRELLRRLLERLGYEVTTAEDGAEALELLRAGPPDLILLDINMPGMDGLELLRRIRALPrLPDIPIIAL 85

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1314866290 267 TGKISTG---EASEDEIADIVSsfnarceeKPVRLPILFAEVARALK 310
Cdd:COG0784    86 TAYADEEdreRALEAGADDYLT--------KPVDPEELLEALRRLLA 124
AtoC COG2204
DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, ...
 188-310 8.15e-09

DNA-binding transcriptional response regulator, NtrC family, contains REC, AAA-type ATPase, and a Fis-type DNA-binding domains [Signal transduction mechanisms];


Pssm-ID: 441806 [Multi-domain]  Cd Length: 418  Bit Score: 56.13  E-value: 8.15e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1314866290 188 ARIAVVDDSPDVAETICEYFAEKGVAAIAYYDSVSFRKALEVEDFDGYILDWLLGEETAAPLVRGIRAsENADAPIFLLT 267
Cdd:COG2204     3 ARILVVDDDPDIRRLLKELLERAGYEVETAASGEEALALLREEPPDLVLLDLRMPGMDGLELLRELRA-LDPDLPVILLT 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1314866290 268 GKISTG---EASEDEIADIVssfnarceEKPVRLPILFAEVARALK 310
Cdd:COG2204    82 GYGDVEtavEAIKAGAFDYL--------TKPFDLEELLAAVERALE 119
PleD COG3706
Two-component response regulator, PleD family, consists of two REC domains and a diguanylate ...
 188-305 2.07e-07

Two-component response regulator, PleD family, consists of two REC domains and a diguanylate cyclase (GGDEF) domain [Signal transduction mechanisms, Transcription];


Pssm-ID: 442920 [Multi-domain]  Cd Length: 179  Bit Score: 50.29  E-value: 2.07e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1314866290 188 ARIAVVDDSPDVAETICEYFAEKGVAAIAYYDSVSFRKALEVEDFDGYILDWLLGEETAAPLVRGIRASEN-ADAPIFLL 266
Cdd:COG3706     2 ARILVVDDDPTNRKLLRRLLEAAGYEVVEAADGEEALELLQEHRPDLILLDLEMPDMDGLELCRRLRADPRtADIPIIFL 81

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1314866290 267 TGkistgeasEDEIADIVSSFNARCEE---KPVRLPILFAEV 305
Cdd:COG3706    82 TA--------LDDEEDRARALEAGADDyltKPFDPEELLARV 115
RpfG COG3437
Response regulator c-di-GMP phosphodiesterase, RpfG family, contains REC and HD-GYP domains ...
 188-311 1.16e-06

Response regulator c-di-GMP phosphodiesterase, RpfG family, contains REC and HD-GYP domains [Signal transduction mechanisms];


Pssm-ID: 442663 [Multi-domain]  Cd Length: 224  Bit Score: 48.62  E-value: 1.16e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1314866290 188 ARIAVVDDSPDVAETICEYFAEKGVAAIAYYDSvsfRKALEV---EDFDGYILDWLLGEETAAPLVRGIRASEN-ADAPI 263
Cdd:COG3437     7 PTVLIVDDDPENLELLRQLLRTLGYDVVTAESG---EEALELlleAPPDLILLDVRMPGMDGFELLRLLRADPStRDIPV 83

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1314866290 264 FLLTGkistgeasEDEIADIVSSFNARCEE---KPVRLPILFAEVARALKI 311
Cdd:COG3437    84 IFLTA--------LADPEDRERALEAGADDyltKPFDPEELLARVRNALEL 126
CitB COG4565
DNA-binding response regulator DpiB of citrate/malate metabolism [Transcription, Signal ...
 189-310 4.35e-06

DNA-binding response regulator DpiB of citrate/malate metabolism [Transcription, Signal transduction mechanisms];


Pssm-ID: 443622 [Multi-domain]  Cd Length: 138  Bit Score: 45.73  E-value: 4.35e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1314866290 189 RIAVVDDSPDVAETICEYFAE-KGVAAIAYYDSV-SFRKALEVEDFDGYILDWLLGEETAAPLVRGIRAsENADAPIFLL 266
Cdd:COG4565     5 RVLIVEDDPMVAELLRRYLERlPGFEVVGVASSGeEALALLAEHRPDLILLDIYLPDGDGLELLRELRA-RGPDVDVIVI 83

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1314866290 267 TgkistgeaSEDEIADIVSSFNARCE---EKPVRLPILFAEVARALK 310
Cdd:COG4565    84 T--------AARDPETVREALRAGVVdylIKPFTFERLREALERYLE 122
REC_OmpR_PhoB cd17618
phosphoacceptor receiver (REC) domain of PhoB response regulator from the OmpR family; The ...
 188-289 1.63e-05

phosphoacceptor receiver (REC) domain of PhoB response regulator from the OmpR family; The transcription factor PhoB is a component of the PhoR/PhoB two-component system, a key regulatory protein network that facilitates response to inorganic phosphate (Pi) starvation conditions by turning on the phosphate (pho) regulon whose products are involved in phosphorus uptake and metabolism. PhoB is a member of the OmpR family of DNA-binding response regulators that contains REC and winged helix-turn-helix (wHTH) DNA-binding output effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381133 [Multi-domain]  Cd Length: 118  Bit Score: 43.39  E-value: 1.63e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1314866290 188 ARIAVVDDSPDVAETICEYFAEKGVAAIAYYDSVSFRKALEVEDFDGYILDWLLGEETAAPLVRGIRASEN-ADAPIFLL 266
Cdd:cd17618     1 RTILIVEDEPAIREMIAFNLERAGFDVVEAEDAESAVNLIVEPRPDLILLDWMLPGGSGIQFIRRLKRDEMtRDIPIIML 80

                          90       100
                  ....*....|....*....|...
gi 1314866290 267 TGKistgeASEDeiaDIVSSFNA 289
Cdd:cd17618    81 TAR-----GEEE---DKVRGLEA 95
REC_OmpR_VirG cd17594
phosphoacceptor receiver (REC) domain of VirG-like OmpR family response regulators; VirG is ...
 190-268 1.78e-05

phosphoacceptor receiver (REC) domain of VirG-like OmpR family response regulators; VirG is part of the VirA/VirG two-component system that regulates the expression of virulence (vir) genes. The histidine kinase VirA senses a phenolic wound response signal, undergoes autophosphorylation, and phosphorelays to the VirG response regulator, which induces transcription of the vir regulon. VirG belongs to the OmpR family of DNA-binding response regulators that contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381125 [Multi-domain]  Cd Length: 113  Bit Score: 43.20  E-value: 1.78e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1314866290 190 IAVVDDSPDVAETICEYFAEKGVAAIAYYDSVSFRKALEVEDFDGYILDWLLGEETAAPLVRGIRASenADAPIFLLTG 268
Cdd:cd17594     2 VLVVDDDAAMRHLLILYLRERGFDVTAAADGAEEARLMLHRRVDLVLLDLRLGQESGLDLLRTIRAR--SDVPIIIISG 78
ompR PRK09468
osmolarity response regulator; Provisional
 189-269 2.08e-05

osmolarity response regulator; Provisional


Pssm-ID: 181883 [Multi-domain]  Cd Length: 239  Bit Score: 44.96  E-value: 2.08e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1314866290 189 RIAVVDDSPDVAETICEYFAEKGVAAIAYYDSVSFRKALEVEDFDGYILDWLLGEETAAPLVRGIRASENaDAPIFLLTG 268
Cdd:PRK09468    7 KILVVDDDMRLRALLERYLTEQGFQVRSAANAEQMDRLLTRESFHLMVLDLMLPGEDGLSICRRLRSQNN-PTPIIMLTA 85


                  .
gi 1314866290 269 K 269
Cdd:PRK09468   86 K 86
REC cd00156
phosphoacceptor receiver (REC) domain of response regulators (RRs) and pseudo response ...
 192-269 4.89e-05

phosphoacceptor receiver (REC) domain of response regulators (RRs) and pseudo response regulators (PRRs); Two-component systems (TCSs) involving a sensor and a response regulator are used by bacteria to adapt to changing environments. Processes regulated by two-component systems in bacteria include sporulation, pathogenicity, virulence, chemotaxis, and membrane transport. Response regulators (RRs) share the common phosphoacceptor REC domain and different effector/output domains such as DNA, RNA, ligand-binding, protein-binding, or enzymatic domains. Response regulators regulate transcription, post-transcription or post-translation, or have functions such as methylesterases, adenylate or diguanylate cyclase, c-di-GMP-specific phosphodiesterases, histidine kinases, serine/threonine protein kinases, and protein phosphatases, depending on their output domains. The function of some output domains are still unknown. TCSs are found in all three domains of life - bacteria, archaea, and eukaryotes, however, the presence and abundance of particular RRs vary between the lineages. Archaea encode very few RRs with DNA-binding output domains; most are stand-alone REC domains. Among eukaryotes, TCSs are found primarily in protozoa, fungi, algae, and green plants. REC domains function as phosphorylation-mediated switches within RRs, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381085 [Multi-domain]  Cd Length: 99  Bit Score: 41.44  E-value: 4.89e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1314866290 192 VVDDSPDVAETICEYFAEKGVAAIAYYDSVSFRKALEVEDFDGYILDWLLGEETAAPLVRGIRAsENADAPIFLLTGK 269
Cdd:cd00156     2 IVDDDPAIRELLKSLLEREGYEVDTAADGEEALELLREERPDLVLLDLMMPGMDGLELLRKLRE-LPPDIPVIVLTAK 78
COG4567 COG4567
DNA-binding response regulator, ActR/RegA family, consists of REC and Fis-type HTH domains ...
 184-277 9.71e-05

DNA-binding response regulator, ActR/RegA family, consists of REC and Fis-type HTH domains [Signal transduction mechanisms, Transcription];


Pssm-ID: 443624 [Multi-domain]  Cd Length: 177  Bit Score: 42.21  E-value: 9.71e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1314866290 184 SAYEARIAVVDDSPDVAETICEYFAEKGVAAIAYYDSVSFRKALEVEDFDGYILDWLLGEETAAPLVRGIRASeNADAPI 263
Cdd:COG4567     1 SAEDRSLLLVDDDEAFARVLARALERRGFEVTTAASVEEALALLEQAPPDYAVLDLRLGDGSGLDLIEALRER-DPDARI 79

                          90
                  ....*....|....
gi 1314866290 264 FLLTGKISTGEASE 277
Cdd:COG4567    80 VVLTGYASIATAVE 93
REC_OmpR_BsPhoP-like cd19937
phosphoacceptor receiver (REC) domain of BsPhoP-like OmpR family response regulators; Bacillus ...
 192-269 9.93e-05

phosphoacceptor receiver (REC) domain of BsPhoP-like OmpR family response regulators; Bacillus subtilis PhoP (BsPhoP) is part of the PhoPR two-component system that participates in a signal transduction network that controls adaptation of the bacteria to phosphate deficiency by regulating (activating or repressing) genes of the Pho regulon upon phosphorylation by PhoR. When activated, PhoPR directs expression of phosphate scavenging enzymes, lowers synthesis of the phosphate-rich wall teichoic acid (WTA) and initiates synthesis of teichuronic acid, a non-phosphate containing replacement anionic polymer. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381164 [Multi-domain]  Cd Length: 116  Bit Score: 41.10  E-value: 9.93e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1314866290 192 VVDDSPDVAETICEYFAEKGVAAIAYYDSVSFRKALEVEDFDGYILDWLLGEETAAPLVRGIRASEN-ADAPIFLLTGK 269
Cdd:cd19937     2 VVDDEEDIVELLKYNLEKEGYEVVTAYDGEEALKRAKDEKPDLIILDLMLPGIDGLEVCRILRSDPKtSSIPIIMLTAK 80
REC_OmpR_CusR-like cd19935
phosphoacceptor receiver (REC) domain of CusR-like OmpR family response regulators; ...
 190-289 1.83e-04

phosphoacceptor receiver (REC) domain of CusR-like OmpR family response regulators; Escherichia coli CusR is part of the CusS/CusR two-component system (TCS) that is involved in response to copper and silver. Other members of this subfamily include Escherichia coli PcoR, Pseudomonas syringae CopR, and Streptomyces coelicolor CutR, which are all transcriptional regulatory proteins and components of TCSs that regulate genes involved in copper resistance and/or metabolism. member of the subfamily is Escherichia coli HprR (hydrogen peroxide response regulator), previously called YdeW, which is part of the HprSR (or YedVW) TCS involved in stress response to hydrogen peroxide, as well as Cupriavidus metallidurans CzcR, which is part of the CzcS/CzcR TCS involved in the control of cobalt, zinc, and cadmium homeostasis. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which contain N-terminal receiver (REC) and C-terminal DNA-binding winged helix-turn-helix effector domains. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381162 [Multi-domain]  Cd Length: 100  Bit Score: 40.12  E-value: 1.83e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1314866290 190 IAVVDDSPDVAETICEYFAEKGVAAIAYYDSVSFRKALEVEDFDGYILDWLLGEETAAPLVRGIRASENaDAPIFLLTGK 269
Cdd:cd19935     1 ILVVEDEKKLAEYLKKGLTEEGYAVDVAYDGEDGLHLALTNEYDLIILDVMLPGLDGLEVLRRLRAAGK-QTPVLMLTAR 79

                          90       100
                  ....*....|....*....|
gi 1314866290 270 istgeaseDEIADIVSSFNA 289
Cdd:cd19935    80 --------DSVEDRVKGLDL 91
REC_OmpR_ArcA_TorR-like cd17619
phosphoacceptor receiver (REC) domain of ArcA- and TorR-like OmpR family response regulators; ...
 188-284 1.53e-03

phosphoacceptor receiver (REC) domain of ArcA- and TorR-like OmpR family response regulators; This subfamily includes Escherichia coli TorR and ArcA, both OmpR family response regulators that mediate adaptation to changes in various respiratory growth conditions. The TorS-TorR two-component system (TCS) is responsible for the tight regulation of the torCAD operon, which encodes the trimethylamine N-oxide (TMAO) reductase respiratory system in response to anaerobic conditions and the presence of TMAO. The ArcA-ArcB TCS is involved in cell growth during anaerobiosis. ArcA is a global regulator that controls more than 30 operons involved in redox regulation (the Arc modulon). OmpR family DNA-binding response regulators are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381134 [Multi-domain]  Cd Length: 113  Bit Score: 37.75  E-value: 1.53e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1314866290 188 ARIAVVDDSPDVAETICEYFAEKGVAAIAYYDSVSFRKALEVEDFDGYILDWLLGEETAAPLVRGIRasENADAPIFLLT 267
Cdd:cd17619     1 PHILIVEDEPVTRATLKSYFEQEGYDVSEAGDGEEMRQILARQDIDLVLLDINLPGKDGLSLTRELR--EQSEVGIILVT 78

                          90
                  ....*....|....*..
gi 1314866290 268 GKistgeasEDEIADIV 284
Cdd:cd17619    79 GR-------DDEVDRIV 88
Response_reg pfam00072
Response regulator receiver domain; This domain receives the signal from the sensor partner in ...
 190-269 1.56e-03

Response regulator receiver domain; This domain receives the signal from the sensor partner in bacterial two-component systems. It is usually found N-terminal to a DNA binding effector domain.


Pssm-ID: 395025 [Multi-domain]  Cd Length: 111  Bit Score: 37.52  E-value: 1.56e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1314866290 190 IAVVDDSPDVAETICEYFAEKGVAAIAYYDSVSFRKALEVEDFDGYILDWLLGEETAAPLVRGIRAsENADAPIFLLTGK 269
Cdd:pfam00072   1 VLIVDDDPLIRELLRQLLEKEGYVVAEADDGKEALELLKEERPDLILLDINMPGMDGLELLKRIRR-RDPTTPVIILTAH 79
REC_OmpR_BaeR-like cd19938
phosphoacceptor receiver (REC) domain of BaeR-like OmpR family response regulators; BaeR is ...
 189-270 2.66e-03

phosphoacceptor receiver (REC) domain of BaeR-like OmpR family response regulators; BaeR is part of the BaeSR two-component system that is involved in regulating genes that confer multidrug and metal resistance. In Salmonella, BaeSR induces AcrD and MdtABC drug efflux systems, increasing multidrug and metal resistance. In Escherichia coli, BaeR stimulates multidrug resistance via mdtABC (multidrug transporter ABC, formerly known as yegMNO) genes, which encode a resistance-nodulation-cell division (RND) drug efflux system. Members of this subfamily belong to the OmpR family of DNA-binding response regulators, which are characterized by a REC domain and a winged helix-turn-helix (wHTH) DNA-binding output effector domain. REC domains function as phosphorylation-mediated switches within response regulators, but some also transfer phosphoryl groups in multistep phosphorelays.


Pssm-ID: 381165 [Multi-domain]  Cd Length: 114  Bit Score: 36.97  E-value: 2.66e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1314866290 189 RIAVVDDSPDVAETICEYFAEKGVAAIAYYDSVSFRKALEVEDFDGYILDWLLGEETAAPLVRGIRASenADAPIFLLTG 268
Cdd:cd19938     1 RILIVEDEPKLAQLLIDYLRAAGYAPTLLAHGDQVLPYVRHTPPDLILLDLMLPGTDGLTLCREIRRF--SDVPIIMVTA 78


                  ..
gi 1314866290 269 KI 270
Cdd:cd19938    79 RV 80
PRK13856 PRK13856
two-component response regulator VirG; Provisional
 190-268 5.39e-03

two-component response regulator VirG; Provisional


Pssm-ID: 172377 [Multi-domain]  Cd Length: 241  Bit Score: 37.87  E-value: 5.39e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1314866290 190 IAVVDDSPDVAETICEYFAEKGVAAIAYYDSVSFRKALEVEDFDGYILDWLLGEETAAPLVRGIraSENADAPIFLLTG 268
Cdd:PRK13856    4 VLVIDDDVAMRHLIVEYLTIHAFKVTAVADSQQFNRVLASETVDVVVVDLNLGREDGLEIVRSL--ATKSDVPIIIISG 80
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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