|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_UhpC |
cd17488 |
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane ... |
30-424 |
4.20e-171 |
|
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane sensor protein UhpC acts as both a sensor and a transport protein. It is part of the UhpABC signaling cascade that controls the expression of the hexose phosphate transporter UhpT. UhpC recognizes external glucose-6-phosphate (Glc6P) and induces transport by UhpT. It can also transport and sense Glc6P, and interacts with the histidine kinase UhpB, leading to the stimulation of the autokinase activity of UhpB. This group also includes the hexose phosphate transport protein UhpT from Chlamydia pneumoniae; it is a transport protein for sugar phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The UhpC group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341041 [Multi-domain] Cd Length: 364 Bit Score: 484.22 E-value: 4.20e-171
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1321042082 30 RFEIIDSVFISYAVFYLTRKNFSAAMPAMLTQTSLTAEDFAIMSSIFYILYGAMKFVGGMLVDKINPKAMTGPVLIGVGI 109
Cdd:cd17488 1 RIHILASMFIGYAVFYLTRKSFNAAMPAMLADLGLDKSDIGILGSLFYITYGVSKFVSGLMSDRSNPRYFMGIGLIATGI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1321042082 110 VNILFGFSDSVAAFYVLYSLNAILQGTSFPPMAKIMASWFSKNERGRWWAIVEAAHNIGGSLAPLLTSFAIAFSGsWKMG 189
Cdd:cd17488 81 INILFGFSSSLWAFAVLWTLNAFFQGWGWPPCARLLTHWYSRNERGFWWSIWNTSHNIGGALIPILTGFAALTYG-WRAG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1321042082 190 FYVPGAISLLMGIVALFTIKDRPgtlglpnvgqwrndptelaqvkaspvnlsfwqifvkyiltnPLVWIIIIGDMSVYIA 269
Cdd:cd17488 160 MYVPGIIAILMGIVLCWRLRDRP-----------------------------------------PYIWLLAFCYVLVYVV 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1321042082 270 RTILNDWPQIYYSQVHGWSLIKANSIISWFEAGGLAGGLLAGYLSDFMFKSNRWMTGLIFALALCICIVLVPLVQDTSYT 349
Cdd:cd17488 199 RTAINDWGNLYLSETHGYSLVKANSAVSLFEVGGLIGALVAGWGSDKLFKGNRGPMNLIFALGLLVSVGALWLVPVHSYW 278
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1321042082 350 LTAILFTIMGFALYGPHMLFAVGCLDVTHKDAAGSITGFRGLFSYVGAAMAGVPVIMVKNSWAWSGVYIYALIAI 424
Cdd:cd17488 279 LLATCFFTIGFFVFGPQMLIGMAAAECSHKDAAGSATGFVGLFAYLGAALAGYPLAKVIESWGWSGFFIVISIAA 353
|
|
| PRK11663 |
PRK11663 |
glucose-6-phosphate receptor/MFS transporter UhpC; |
11-423 |
2.29e-126 |
|
glucose-6-phosphate receptor/MFS transporter UhpC;
Pssm-ID: 183266 [Multi-domain] Cd Length: 434 Bit Score: 372.89 E-value: 2.29e-126
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1321042082 11 PDKPIVKEKKKIDQTYKKFRFEIIDSVFISYAVFYLTRKNFSAAMPAMLTQTSLTAEDFAIMSSIFYILYGAMKFVGGML 90
Cdd:PRK11663 2 ADAPLITDKHEIDARYRYWRRHILITMYLGYALFYFTRKSFNAAMPEMLADLGLSRSDIGLLATLFYITYGVSKFVSGIV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1321042082 91 VDKINPKAMTGPVLIGVGIVNILFGFSDSVAAFYVLYSLNAILQGTSFPPMAKIMASWFSKNERGRWWAIVEAAHNIGGS 170
Cdd:PRK11663 82 SDRSNARYFMGIGLIATGIINILFGFSSSLWAFALLWVLNAFFQGWGWPVCAKLLTAWYSRTERGGWWAIWNTAHNVGGA 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1321042082 171 LAPLLTSFaIAFSGSWKMGFYVPGAISLLMGIVALFTIKDRPGTLGLPNVGQWRNDPTELAQVKASPvNLSFWQIFVKYI 250
Cdd:PRK11663 162 LIPLVVGA-IALHYGWRYGMMIAGIIAIVVGLFLCWRLRDKPQAMGLPSVGEWRHDALELAQQQEGA-GLSRKEILTKYV 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1321042082 251 LTNPLVWIIIIGDMSVYIARTILNDWPQIYYSQVHGWSLIKANSIISWFEAGGLAGGLLAGYLSDFMFKSNRWMTGLIFA 330
Cdd:PRK11663 240 LLNPYIWLLSFSYVLVYVVRAAINDWGNLYMSETLGVDLVTANSAVSMFELGGFIGALVAGWGSDKLFNGNRGPMNLIFA 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1321042082 331 LALCICIVLVPLVQDTSYTLTAILFTIMGFALYGPHMLFAVGCLDVTHKDAAGSITGFRGLFSYVGAAMAGVPVIMVKNS 410
Cdd:PRK11663 320 AGILLSVGSLWLMPFASYVMQAACFFTIGFFVFGPQMLIGMAAAECSHKEAAGAATGFVGLFAYLGAALSGYPLAKVLEI 399
|
410
....*....|...
gi 1321042082 411 WAWSGVYIYALIA 423
Cdd:PRK11663 400 WHWTGFFVVISIA 412
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
30-423 |
8.02e-92 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 283.75 E-value: 8.02e-92
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1321042082 30 RFEIIDSVFISYAVFYLTRKNFSAAMPAMLTQTSLTAEDFAIMSSIFYILYGAMKFVGGMLVDKINPKAMTGPVLIGVGI 109
Cdd:cd17345 1 RWQVFLGIFIGYAGYYLVRNNFSLAQPYLIEQYGLSKTEIGLIGSALSIAYGLSKFVMGNLSDRSNPKRFLAIGLILSAI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1321042082 110 VNILFGFSD----SVAAFYVLYSLNAILQGTSFPPMAKIMASWFSKNERGRWWAIVEAAHNIGGSLAPLLT--SFAIAFS 183
Cdd:cd17345 81 INILIGFVPsatsSVGLMFILLFLNGWFQGMGWPPSGRTMVHWFSKKERGTWTSIWNISHNVGGGLVGPLAglGLAIFGD 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1321042082 184 GSWKMGFYVPGAISLLMGIVALFTIKDRPGTLGLPNVGQWRNDPTELAQVKASPVNLSFWQIFVKYILTNPLVWIIIIGD 263
Cdd:cd17345 161 GWWRGAFIFPAIIAIIVAVIVLFLGKDTPESEGLPPIEEYKGDYPEEADGEEEEQELSAWEIFVKYVLKNKLLWYIAIAN 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1321042082 264 MSVYIARTILNDWPQIYYSQVHGWSLIKANSIISWFEAGGLAGGLLAGYLSDFMFKSNRWMTGLIFaLALCICIVLVpLV 343
Cdd:cd17345 241 VFVYLVRYGILDWAPTYLSEVKGFSKAQAMWAFSLFEWAAIPGTLLAGWLSDKLFKGRRAPTGIIF-MILVIVALIV-YW 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1321042082 344 QDTSYTLTAILFTIMGFALYGPHMLFAVGCLDVTHKDAAGSITGFRGLFSYV-GAAMAGVPVIMVKNSWAWSGVYIYALI 422
Cdd:cd17345 319 LAPNVLVDLIALIALGFLIYGPVMLIGLQALELVPKKAAGTAAGLTGLFGYLgGSVLATALIGIIVDHFGWNGGFIVLLA 398
|
.
gi 1321042082 423 A 423
Cdd:cd17345 399 S 399
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
38-415 |
8.13e-92 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 282.73 E-value: 8.13e-92
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1321042082 38 FISYAVFYLTRKNFSAAMPAMLTQTSLTAEDFAIMSSIFYILYGAMKFVGGMLVDKINPKAMTGPVLIGVGIVNILFGFS 117
Cdd:TIGR00881 1 FIGYAAYYLVRKNFALAMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1321042082 118 DSVAAFYVLYSLNAILQGTSFPPMAKIMASWFSKNERGRWWAIVEAAHNIGGSLAPLLTSFAIAFSGSWKMGFYVPGAIS 197
Cdd:TIGR00881 81 TSLWVMAALWALNGIFQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLVLFGIAELYSWHWVFIVPGIIA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1321042082 198 LLMGIVALFTIKDRPGTLGLPNVGQWRNDPTELAQVKAsPVNLSFWQIFVKYILTNPLVWIIIIGDMSVYIARTILNDWP 277
Cdd:TIGR00881 161 IIVSLICFLLLRDSPQSCGLPPAEEMPNEEPDGDAEKK-EEELTKKQIFLQYVLLNKVLWYISLGYVFVYVVRTGILDWS 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1321042082 278 QIYYSQVHGWSLIKANSIISWFEAGGLAGGLLAGYLSDFMFKSNRWMTGLIFALALCICIVLVPLVQDTSYTLTAILFTI 357
Cdd:TIGR00881 240 PLYLTQEKGFSKEKASWAFTLYELGGLVGTLLAGWLSDKLFNGRRGPLAVFFMALIIVSLLVYWLNPAANPLMDLICLFA 319
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 1321042082 358 MGFALYGPHMLFAVGCLDVTHKDAAGSITGFRGLFSYVGAAMAGVPVIMVKNSWAWSG 415
Cdd:TIGR00881 320 LGFLVYGPQMLIGVIASELAPKKAAGTAAGFVGFFAYLGGILAGLPLGYLADGFGWAG 377
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
30-423 |
8.44e-71 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 227.93 E-value: 8.44e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1321042082 30 RFEIIDSVFISYAVFYLTRKNFSAAMPAMLTQTSLTAEDFAIMSSIFYILYGAMKFVGGMLVDKINPKAMTGPVLIGVGI 109
Cdd:cd17312 1 RWRIFLGVFLGYAAYYVCRKNFSVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1321042082 110 VNILFGFSDSVAAFYVLYSLNAILQGTSFPPMAKIMASWFSKNERGRWWAIVEAAHNIGGSLAPLLTSFAIAfSGSWKMG 189
Cdd:cd17312 81 ANIFMGFSTSLWFFAVLWGLNGLFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLAS-YYGWRAA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1321042082 190 FYVPGAISLLMGIVALFTIKDRPgtlglpnvgqwrndptelaqvkaspvnlsfwqifvkyiltnPLVWIIIIGDMSVYIA 269
Cdd:cd17312 160 FLVPGIVGLVVAIILFFFLRDSP-----------------------------------------PYVWVLSLAYAFVYIV 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1321042082 270 RTILNDWPQIYYSQVHGWSLIKANSIISWFEAGGLAGGLLAGYLSDFMFKSNRWMTGLIFALALCICIVLVPLVQDtSYT 349
Cdd:cd17312 199 RYACLDWGPLYLYEVKGYSLIDAGWFSSLYEVGGIAGTILAGLLSDKLFGGRRAPIAVIYMLLMTLSLALFWFFPH-NKL 277
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1321042082 350 LTAILFTIMGFALYGPHMLFAVGCL-DVTHKDAAGSITGFRGLFSYVGAAMAGVPVIMVKNSWAWSGVYIYALIA 423
Cdd:cd17312 278 LSIVLLFLIGFFVGGPINLIGGAAAqDIGRKEAAGTATGFVGLFGYLGASLAGLPLGYIIDHYGWSTVFYFLISA 352
|
|
| glpT |
PRK11273 |
glycerol-3-phosphate transporter; |
21-400 |
9.65e-66 |
|
glycerol-3-phosphate transporter;
Pssm-ID: 236889 [Multi-domain] Cd Length: 452 Bit Score: 217.27 E-value: 9.65e-66
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1321042082 21 KIDQTYKKFRFEIIDSVFISYAVFYLTRKNFSAAMPAMLTQtSLTAEDFAIMSSIFYILYGAMKFVGGMLVDKINPKAMT 100
Cdd:PRK11273 18 EIDPTYRRLRWQIFLGIFFGYAAYYLVRKNFALAMPYLVEQ-GFSRGDLGFALSGISIAYGFSKFIMGSVSDRSNPRVFL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1321042082 101 GPVLIGVGIVNILFGF----SDSVAAFYVLYSLNAILQGTSFPPMAKIMASWFSKNERGRWWAIVEAAHNIGGSLAPLLT 176
Cdd:PRK11273 97 PAGLILAAAVMLFMGFvpwaTSSIAVMFVLLFLCGWFQGMGWPPCGRTMVHWWSQKERGGIVSVWNCAHNVGGGLPPLLF 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1321042082 177 SFAIAFSGSWKMGFYVPGAISLLMGIVALFTIKDRPGTLGLPNVGQWRNDPTELAQVKASPvNLSFWQIFVKYILTNPLV 256
Cdd:PRK11273 177 LLGMAWFNDWHAALYMPAFAAILVALFAFAMMRDTPQSCGLPPIEEYKNDYPDDYNEKHEQ-ELTAKQIFMQYVLPNKLL 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1321042082 257 WIIIIGDMSVYIARTILNDWPQIYYSQVHGWSLIKANSIISWFEAGGLAGGLLAGYLSDFMFKSNRWMTGLIFALALCIC 336
Cdd:PRK11273 256 WYIAIANVFVYLLRYGILDWSPTYLKEVKHFALDKSSWAYFLYEYAGIPGTLLCGWMSDKVFRGNRGATGVFFMTLVTIA 335
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1321042082 337 IVLVPLVQDTSYTLTAILFTIMGFALYGPHMLFAVGCLDVTHKDAAGSITGFRGLFSYVGAAMA 400
Cdd:PRK11273 336 TIVYWLNPAGNPTVDMACMIVIGFLIYGPVMLIGLHALELAPKKAAGTAAGFTGLFGYLGGSVA 399
|
|
| MFS_SLC37A4 |
cd17343 |
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute ... |
33-423 |
2.29e-61 |
|
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 4 (SLC37A4), one of four SLC37 family proteins in vertebrates, is better known as glucose-6-phosphate transporter (G6PT). It is also called sugar phosphate exchanger 4 (SPX4), G6P translocase, or transformation-related gene 19 protein (TRG-19). G6PT is a phosphate (Pi)-linked G6P antiporter, catalyzing G6P:Pi and Pi:Pi exchanges. Deficiencies in human G6PT lead to glycogen storage disease type Ib (GSD-Ib), which is a metabolic and immune disorder. G6PT is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340901 [Multi-domain] Cd Length: 409 Bit Score: 204.49 E-value: 2.29e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1321042082 33 IIDSVFISYAVFYLTRKNFSAAMPAMLTQTSLTAEDFAIMSSIFYILYGAMKFVGGMLVDKINPKAMTGPVLIGVGIVNI 112
Cdd:cd17343 4 IFASMFVGYTLYYFNRKSFSFVLPSLMNELGLDKSDLGLITSSQSLAYAISKFIGGVLSDQISARWLFSSGLVLSGLTTV 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1321042082 113 LFGFSDSVAAFYVLYSLNAILQGTSFPPMAKIMASWFSKNERGRWWAIVEAAHNIGGSLAPLLTSFaIAFSGSWKMGFYV 192
Cdd:cd17343 84 AFSGSSSVWVFSILWFLNGLAQGLGWPPCAKILRKWFSPSQFGTWWSVLSTSMNLAGSLGPILATL-LALSYGWRSTLSI 162
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1321042082 193 PGAISLLMGIVALFTIKDRPGTLGLPNVGQWRNDPTElaqvKASPVNLSFWqifvKYILTNPLVWIIIIGDMSVYIARTI 272
Cdd:cd17343 163 SGTVAVVMSVVCLLFIKNEPSDVGLNNIEEEESKGKK----KKSPRGESTL----KELLLSPFLWLLSLGYLVVFGVKTA 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1321042082 273 LNDWPQIYYSQVHGWSLIKANSIISWFEAGGLAGGLLAGYLSDFMFKSN--------RWMTGLIFALALCICIVL--VPL 342
Cdd:cd17343 235 VTDWGQLFLIQDKGQSALTGSSFMSSLEVGGFVGSIAAGYLSDWAVAKHgsssrgnpRMPLALVFMAGLTVSLHLfrVHI 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1321042082 343 VQDTSYTLTAILFTIMGFALYGPHMLFAVGCLDVTHKDAAGSITGFRGLFSYVGAAMAGVPVIMVKNSWAWSGVYIYALI 422
Cdd:cd17343 315 TSDSSELFILLLGFLIGFSLYGPIAIFGVIANESAPSHLCGTSHAIVALAANVGGVLAGLPFSYIAKHYDWRTAFLLLEI 394
|
.
gi 1321042082 423 A 423
Cdd:cd17343 395 L 395
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
23-423 |
2.47e-48 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 168.90 E-value: 2.47e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1321042082 23 DQTYKKFRFEIIDSVFISYAVFYLTRKNFSAAMPAMLTQTSLTAEDFAIMSSIFYILYGAMKFVGGMLVDKINPKAMTGP 102
Cdd:COG2271 1 ARAPSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1321042082 103 VLIGVGIVNILFGFSDSVAAFYVLYSLNAILQGTSFPPMAKIMASWFSKNERGRWWAIVEAAHNIGGSLAPLLTSFAIAF 182
Cdd:COG2271 81 GLLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGWLLAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1321042082 183 SGsWKMGFYVPGAISLLMGIVAlftikdrpgtlglpnvgqwrndptelaqvkaspvnlsfwqifvkyiltnplVWIIIIG 262
Cdd:COG2271 161 FG-WRAAFLILGLPGLLLALLR---------------------------------------------------FWLLALA 188
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1321042082 263 DMSVYIARTILNDWPQIYYSQVHGWSLIKANSIISWFEAGGLAGGLLAGYLSDFMFKSNRWMTGLIFALALcICIVLVPL 342
Cdd:COG2271 189 YFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAA-LALLLLAL 267
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1321042082 343 VqdTSYTLTAILFTIMGFALYGPHMLFAVGCLDVTHKDAAGSITGFRGLFSYVGAAMAGVPVIMVKNSWAWSGVYIYALI 422
Cdd:COG2271 268 L--PSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAA 345
|
.
gi 1321042082 423 A 423
Cdd:COG2271 346 L 346
|
|
| uhpT |
PRK09556 |
hexose-6-phosphate:phosphate antiporter; |
37-402 |
8.64e-47 |
|
hexose-6-phosphate:phosphate antiporter;
Pssm-ID: 236564 [Multi-domain] Cd Length: 467 Bit Score: 167.53 E-value: 8.64e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1321042082 37 VFISYAVFYLTRKNFSAAMPAMLTQTSLTAEDFAIMSSIFYILYGAMKFVGGMLVDKINPKAMTGPVLIGVGIVNILFGF 116
Cdd:PRK09556 34 VFIGYLTMYLIRKNFKAAQNDMISTYGLSTTELGMIGLGFSITYGVGKTLVGYYADGKNTKQFLPFLLILSAICMLGFGA 113
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1321042082 117 S-----DSVAAFYVLYSLNAILQGTSFPPMAKIMASWFSKNERGRWWAIVEAAHNIGGSLAPLLTSFA--IAFSGSWKMG 189
Cdd:PRK09556 114 SlgsgsVSLGLMIALWALSGFFQSTGGPCSYSTITRWTPRRKRGRFLGFWNISHNLGGAGAGGVALWGanYFFDGHVIGM 193
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1321042082 190 FYVPGAISLLMGIVALFTIKDRPGTLGLPNVGQWRNDPTELAQVKASPVNLSFWQIFVKYILTNPLVWIIIIGDMSVYIA 269
Cdd:PRK09556 194 FIFPSIIALIIGFIGLRYGSDSPEELGWGKAEEIFGEPISEEDKETESTDMTKWQIFVEYVLKNPVIWLLCFANIFLYIV 273
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1321042082 270 RTILNDWPQIYYSQVHGWSLIKANSIISWFEAGGLAGGLLAGYLSDFMfKSNRWMTGlIFALALCICIVLVPLVQDTSYT 349
Cdd:PRK09556 274 RIGIDNWSPVYAFQELGFSKEDAINTFTLFEIGALVGSLLWGWLSDLA-NGRRALVA-CIALALIIFTLGVYQHATSEYM 351
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....
gi 1321042082 350 LTAILFtIMGFALYGPHMLFAVGCLDVTHKDAAGSITGFRGLFSYV-GAAMAGV 402
Cdd:PRK09556 352 YLASLF-ALGFLVFGPQLLIGVAAVGFVPKKAIGVANGIKGTFAYLfGDSFAKV 404
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
30-406 |
6.55e-30 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 119.21 E-value: 6.55e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1321042082 30 RFEIIDSVFISYAVFYLTRKNFSAAMPAMLTQTSLTAEDFAIMSSIFYILYGAMKFVGGMLVDKINPKAMTGPVLIGVGI 109
Cdd:cd17319 1 RWRIIPLLFLAYVINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1321042082 110 VNILFGFSDSVAAFYVLYSLNAILQGTSFPPMAKIMASWFSKNERGRWWAIVEAAHNIGGSLAPLLTSFaIAFSGSWKMG 189
Cdd:cd17319 81 FTALTGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGW-LLLLFGWRWA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1321042082 190 FYVPGAISLLMGIVALFTIKdrpgtlglpnvgqwrndptelaqvkaspvnlSFWQIFVKYILTNPLVWIIIIgdmsvyia 269
Cdd:cd17319 160 FIIEGLLGLLLAVLWWFYLR-------------------------------QVWGLALGYFGINYALYGLLT-------- 200
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1321042082 270 rtilndWPQIYYSQVHGWSLIKANSIISWFEAGGLAGGLLAGYLSDFMFKSNR-WMTGLIFALAlCICIVLVPLVQDTsy 348
Cdd:cd17319 201 ------WLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLLRGARrLVIIIGLLLA-AVGLLLAYLTTSP-- 271
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 1321042082 349 TLTAILFTIMGFALYGPHMLFAVGCLDVTHKDAAGSITGFRGLFSYVGAAMAgvPVIM 406
Cdd:cd17319 272 VVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVA--PLLI 327
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
37-400 |
5.30e-26 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 107.89 E-value: 5.30e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1321042082 37 VFISYAVFYLTRKNFSAAMPAMLTQT-SLTAEDFAIMSSIFYILYGAMKFVGGMLVDKINPKAMTGPVLIGVGIVNILFG 115
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDlGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1321042082 116 FSDSVAAFYVLYSLNAILQGTSFPPMAKIMASWFSKNERGRWWAIVEAAHNIGGSLAPLLTSFaIAFSGSWKMGFYVPGA 195
Cdd:pfam07690 81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGL-LASLFGWRAAFLILAI 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1321042082 196 ISLLMGIVALFTIKDRPGTLGLPNVGQWRNDPTELAQVKASPVNLSFWqifvkYILTNPLVWIIIIGDMSVYIartilnd 275
Cdd:pfam07690 160 LSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKALLRDPVLWLLL-----ALLLFGFAFFGLLTYLPLYQ------- 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1321042082 276 wpqiyysQVHGWSLIKANSIISWFEAGGLAGGLLAGYLSDFMFKSNRWMTGLIFALALCICIVLVPLVQDTSYTLTAILF 355
Cdd:pfam07690 228 -------EVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLL 300
|
330 340 350 360
....*....|....*....|....*....|....*....|....*
gi 1321042082 356 TIMGFALYGPHMLFAVgcLDVTHKDAAGSITGFRGLFSYVGAAMA 400
Cdd:pfam07690 301 LGFGFGLVFPALNALV--SDLAPKEERGTASGLYNTAGSLGGALG 343
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
37-423 |
1.87e-23 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 101.35 E-value: 1.87e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1321042082 37 VFISYAVFYLTRKNFSAAMPAMLTQTSLTAEDFAIMSSIFYILYGAMKFVGGMLVDKINPKAMTGPVLIGVGIVNILFGF 116
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1321042082 117 SDSVAAFYVLYSLNAILQGTSFPPMAKIMASWFSKNERGRWWAIVEAAHNIGGSLAPLLTSFAI-AFSGSWKMGFYVPGA 195
Cdd:cd06174 81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILAsSLGFGWRAVFLIAAA 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1321042082 196 ISLLMGIVALFTIKDRPgtlglpnvgqwrndptELAQVKASPVNLSFWQIFVKYILTNPLVWIIIIGDMSVYIARTILND 275
Cdd:cd06174 161 LALLAAILLLLVVPDPP----------------ESARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFST 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1321042082 276 WPQIYYSQVHGWSLIKANSIISWFEAGGLAGGLLAGYLSDFMFKSNRWMTGLIFALALCICIVLVPlvqdTSYTLTAILF 355
Cdd:cd06174 225 LLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLA----PSLLLLLLLL 300
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1321042082 356 TIMGFALYGPHMLFAVGCLDVTHKDAAGSITGFRGLFSYVGAAMAGVPVIMVKNS-WAWSGVYIYALIA 423
Cdd:cd06174 301 LLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAAtFGLTGAFLVLAVL 369
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
36-424 |
5.39e-21 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 94.18 E-value: 5.39e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1321042082 36 SVFISYAVFYLtrknFSAAMPAMLTQTSLTAEDFAIMSSIFYILYGAMKFVGGMLVDKINPKAMTGPVLIGVGIVNILFG 115
Cdd:COG2223 13 AFFLAFGVWYL----WSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLA 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1321042082 116 FSDSVAAFYVLYSLNAILQGTSFPPMAKIMASWFSKNERGRWWAIVEAAHNIGGSLAPLLTSFAIAFSGsWKMGFYVPGA 195
Cdd:COG2223 89 LAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFG-WRNAFLILGI 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1321042082 196 ISLLMGIVALFTIKDRPgtlglpnVGQWRNDPTELAQVKAspvnlsfwqifvkyILTNPLVWIIIIGDMSVYIARTILND 275
Cdd:COG2223 168 LLLVVAVLAWLFLRDPP-------AGAAAAAKASLRDQLE--------------ALRDPRFWLLSLLYFGTFGSFIGFSS 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1321042082 276 WPQIYYSQVHGWSLIKANSIISWFEAGGLAGGLLAGYLSDfmfKSNRWMTGLIFALALCICIVLVPLVQDTSYTLTAILF 355
Cdd:COG2223 227 WLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSD---RIGGRRVLLIVFALMALGLLLLALALGSLWLFLVLFL 303
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1321042082 356 TIMGFALYGPHMLFAVgCLDVTHKDAAGSITGFRGLfsyVGAAMAGVPVIMVKNSWAWSGVYIYALIAI 424
Cdd:COG2223 304 LLGLALGGGNGAVFAL-VPDIFPTKNAGAVYGLVGA---AGGLGGFLGPLLFGALLDATGSYTAAFLVF 368
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
24-400 |
2.76e-18 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 85.80 E-value: 2.76e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1321042082 24 QTYKKFRFEIIDSVFISYAVFYLTRKNFSAAMPAMLTQTSLTAEDFAIMSSIFYILYGAMKFVGGMLVDKINPKAMTGPV 103
Cdd:COG2814 2 PATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1321042082 104 LIGVGIVNILFGFSDSVAAFYVLYSLNAILQGTSFPPMAKIMASWFSKNERGRWWAIVEAAHNIGGSLAPLLTSFAIAFS 183
Cdd:COG2814 82 LLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLF 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1321042082 184 GsWKMGFYVPGAISLLMGIVALFTIKDRPGTLGLPNVGQWRNdptelaqvkaspvnlsfwqifvkyILTNPLVWIIIIGD 263
Cdd:COG2814 162 G-WRWVFLVNAVLALLALLLLLRLLPESRPAARARLRGSLRE------------------------LLRRPRLLLLLLLA 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1321042082 264 MSVYIARTILNDWPQIYYSQVHGWSLIKANSIISWFEAGGLAGGLLAGYLSDfmfKSNRWMTGLIFALALCICIVLVPLV 343
Cdd:COG2814 217 FLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLAD---RFGRRRLLLIGLLLLALGLLLLALA 293
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*..
gi 1321042082 344 qdTSYTLTAILFTIMGFALYGPHMLFAVGCLDVTHKDAAGSITGFRGLFSYVGAAMA 400
Cdd:COG2814 294 --GSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPLA 348
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
38-418 |
1.03e-13 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 72.27 E-value: 1.03e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1321042082 38 FISYAVFYLTRKNFSAAMPAMLTQTSLTAEDFAIMSSIFYILYGAMKFVGGMLVDKINPKAMTGPVLIGVGIVNILFGFS 117
Cdd:cd17475 2 TLAQAAASLVAQGIPALAPFLQEDLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1321042082 118 DSVAAFYVLYSLNAILQGTSFPPMAKIMASWFSKNERGRWWAIVEAAHNIGGSLAPLLTSFaIAFSGSWKMGFYVPGAIS 197
Cdd:cd17475 82 GSYPVLLVLLFLVGAGYGSVQPGGGRAIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPP-LALHYGWRAAFVVAGLVS 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1321042082 198 LLMGIVALFTIKDRPGtlglpnvgqwrndPTELAQVKASPVNLsfwqifVKYILTNPLVWIIIIGDMSVYIARTILNDWP 277
Cdd:cd17475 161 ILAAVLFWLFYREPPA-------------ASAATESASTLLRS------LKEVLRNRDVWLIAIAGALLVAPQFALLTFL 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1321042082 278 QIYYSQVHGWSLIKANSIISWFEAGGLAGGLLAGYLSDFMFKSNRwMTGLIFALALCIC--IVLVPLVQDTSYTLTAILF 355
Cdd:cd17475 222 LLFLHDHLGLSVVAAGALLAVAQLGGALGRIGLGRVSDRVFGGRR-RPVLVITAAIAAAalLVLSLLSPGTPLWLLVLLL 300
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1321042082 356 TIMGFALYGPHMLFAVGCLDVTHKDAAGSITGFRGLFSYVGAAMAgvPVI---MVKNSWAWSGVYI 418
Cdd:cd17475 301 ILLGLFAIGWNGLYLTLVAESAGPEQAGTALGLANTINFIGIAIG--PPLfglLVDATHSYAPAWL 364
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
71-422 |
3.86e-13 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 70.30 E-value: 3.86e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1321042082 71 IMSSIFYILYGAMKFVGGMLVDKINPKAMTGPVLIGVGIVNILFGFSDSVAAFYVLYSLNAILQGTSFPPMAKIMASWFS 150
Cdd:cd17325 35 LIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFLQGLASAAVWPAAMALIADIAP 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1321042082 151 KNERGRWWAIVEAAHNIGGSLAPLLTSFAIAFSGsWKMGFYVPGAISLLMGIVALFTIKDRPgtlglpnvgqwrndptel 230
Cdd:cd17325 115 PEERGRAMGIFSSAIGLGFLIGPLLGGLLADALG-YRAPFLVCAALALLALVLALLLLPEPR------------------ 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1321042082 231 AQVKASPVNLSFWQIFVKYILTNPLVWIIIIGDMSVYIARTILNDWPQIYYSQVHGWSLIKANSIISWFEAGGLAGGLLA 310
Cdd:cd17325 176 PPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPA 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1321042082 311 GYLSDfmfKSNRWMTGLIFALALCICIVLVPLVQDTSYTLTAILFTIMGFALYGPHMLFAVGclDVTHKDAAGSITGFRG 390
Cdd:cd17325 256 GKLSD---RIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLA--DIVPPEGRGTAMGLFN 330
|
330 340 350
....*....|....*....|....*....|..
gi 1321042082 391 LFSYVGAAMAGVPVIMVKNSWAWSGVYIYALI 422
Cdd:cd17325 331 TAFSLGMVLGPLLGGFLYDAFGFATPFLAAAA 362
|
|
| MFS_SLC37A3 |
cd17342 |
Solute carrier family 37 member 3 of the Major Facilitator Superfamily of transporters; Solute ... |
38-424 |
5.94e-13 |
|
Solute carrier family 37 member 3 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 3 (SLC37A3) is also called sugar phosphate exchanger 3 (SPX3), and is one of four SLC37 family proteins in vertebrates. It's function and activity is unknown. The best characterized SLC37 family member is SLC37A4, also called the glucose-6-phosphate transporter (G6PT), a phosphate (Pi)-linked G6P antiporter. SLC37A3 is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340900 [Multi-domain] Cd Length: 399 Bit Score: 70.04 E-value: 5.94e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1321042082 38 FISYAVFYLTRKNFSAAMPAM---LTQTSLTAEDFA----------------------IMSSIFYILYGAMKFVGGMLVD 92
Cdd:cd17342 9 FFSYALLHATRKTFSNVKPSIsaeWTPSNSNTSIELheetwnanplfpsqddaalflgVLDTIFLFSYAIGLFISGWLGD 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1321042082 93 KINPKAMTGPVLIGVGIVNILFGFSDSVAAFY------VLYSLNAILQGTSFPPMAKIMASWFSKNERGRWWAIVEAAHN 166
Cdd:cd17342 89 RLNLRLVLAFGMCSSAITVFLFGVLTEWLHFYnkylycILWVLNGLLQSTGWPCVVAIMGNWFGKSSRGFVLGLWSACAS 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1321042082 167 IGGSLAPLLTSFAIAFSGSWkmGFYVPGAISLLMGIVALFTIKDRPgtlglPNVgqwrnDPTELAQVKASPVNLSFWqiF 246
Cdd:cd17342 169 VGNIIGALLASSVLDYGYEY--AFLVTSSLLFAGAIVVFFGLLSSP-----PGV-----IPYSLAYACLKLVNYSFF--F 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1321042082 247 vkyiltnplvwiiiigdmsvyiartilndWPQIYYSQVHGWSLIKANSIISWFEAGGLAGGLLAGYLSDFMFKSNrWMTG 326
Cdd:cd17342 235 -----------------------------WLPFYLSNNFHWKESEADQLSIWYDVGGIIGGIVAGYISDRMGSRS-PVVV 284
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1321042082 327 LIfaLALCICIVLVPLVQDTSYTLTAILFTIMGFALYGP-HMLFAVGCLDV-------THKDAAGSITGFRGLFSYVGAA 398
Cdd:cd17342 285 VM--LLLAIPSLFVYSHSPSDKVLNAFVMTITGFFIGGPaNLISSAISADLgrqpqlrGSSEALATVTGIIDGTGSIGAA 362
|
410 420
....*....|....*....|....*.
gi 1321042082 399 MAGVPVIMVKNSWAWSGVYIYALIAI 424
Cdd:cd17342 363 IGQVLVPLIQNRLGWMWVFYFFIIMT 388
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
28-212 |
8.94e-13 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 69.59 E-value: 8.94e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1321042082 28 KFRFEIIDSVFISYAVFYLTRKNFS-AAMPAMLTQTSLTAEDFAIMSSIFYILYGAMKFVGGMLVDKINPKAMTGPVLIG 106
Cdd:cd17327 1 KLDLFILPLLCILYFLQYLDKSNISnAAVMGMKEDLKLVGNQYNWGNTVFYVGYIIFELPGNLLLQRFPPSKWLSVFIVL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1321042082 107 VGIVNILFGFSDSVAAFYVLYSLNAILQGTSFPPMAKIMASWFSKNERGRWWAIVEAAHNIGGSLAPLLTS--FAIAFSG 184
Cdd:cd17327 81 WGLLTLLTAAVKNFGGLIALRFFLGLFESGVFPGFILYLGMWYKREEQAKRIAFFYAAAGLGSIFGGLLAYgvFKILGVG 160
|
170 180 190
....*....|....*....|....*....|.
gi 1321042082 185 S---WKMGFYVPGAISLLMGIVALFTIKDRP 212
Cdd:cd17327 161 GlagWRWLFIIEGLITIIIGLVIFFWLPDNP 191
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
37-243 |
3.61e-11 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 64.56 E-value: 3.61e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1321042082 37 VFISYAVFYLTRKNFSAAMPAMLTQTSLTAEDFAIMSSIFYILYGAMKFVGGMLVDKINPKAMtgpVLIGV---GIVNIL 113
Cdd:cd17328 4 LFLINLLNYMDRFTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWI---LAVGIliwSAATLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1321042082 114 FGFSDSVAAFYVLYSLNAILQGTSFPPMAKIMASWFSKNERGRWWAIVEAAHNIGGSLAPLLTSFAIAFSGSWKMGFYVP 193
Cdd:cd17328 81 SSFAPNFWQLLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQATGGWRWAFRVT 160
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 1321042082 194 GAISLLMGIVALFTIKDRPGTLGLPNVGQWRNDPTELAQVKASPVNLSFW 243
Cdd:cd17328 161 GVLGVLLAILLLLFVREPPRGAAEGGVMAKSTATSFLADLKALAKNPSFI 210
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
64-206 |
1.31e-09 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 59.51 E-value: 1.31e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1321042082 64 LTAEDFAIMSSIFYILYGAMKFVGGMLVDKINPKAMTGPVLIGVGIVNILFGFSDSVAAFYVLYSLNAILQGTSFPPMAK 143
Cdd:cd17325 232 LSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLA 311
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1321042082 144 IMASWFSKNERGRWWAIVEAAHNIGGSLAPLLTSFaIAFSGSWKMGFYVPGAISLLMGIVALF 206
Cdd:cd17325 312 LLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGF-LYDAFGFATPFLAAAALLLLAAVLFLL 373
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
38-199 |
2.77e-09 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 58.33 E-value: 2.77e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1321042082 38 FISYAVFYLTRKNFSAAMPAMLTQTSLTAEDFAIMSSIFYILYGAMKFVGGMLVDKINPKAMTGPVLIGVGIVNIL--FG 115
Cdd:cd17380 5 FLATCICYADRVNMPIAIVPMAKEFGWSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLATLLtpLL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1321042082 116 FSDSVAAFYVLYSLNAILQGTSFPPMAKIMASWFSKNERGRWWAIVEAAHNIGGSLAPLLTSFAIAFSGsWKMGFYVPGA 195
Cdd:cd17380 85 AYSSLPLLILSRILLGLGEGVHFPSMTSLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLEYYG-WPSVFYFFGL 163
|
....
gi 1321042082 196 ISLL 199
Cdd:cd17380 164 LGLL 167
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
37-212 |
2.86e-09 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 58.34 E-value: 2.86e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1321042082 37 VFISYAVFYLTRKNFSAAMPAMLTQT-SLTAEDFAIMSSIFYILYGAMKFVGGMLVDKIN--PKAMTGPVLIGVGIVNIL 113
Cdd:COG2271 185 LALAYFLVYFALYGFLTWLPTYLVEVrGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGrrRKLVLAIGLLLAALALLL 264
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1321042082 114 FGFSDSVAAFYVLYSLNAILQGTSFPPMAKIMASWFSKNERGRWWAIVEAAHNIGGSLAPLLTSFAIAFSGsWKMGFYVP 193
Cdd:COG2271 265 LALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATG-YQAAFLLL 343
|
170
....*....|....*....
gi 1321042082 194 GAISLLMGIVALFTIKDRP 212
Cdd:COG2271 344 AALALLAALLALLLLRETR 362
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
51-252 |
5.43e-09 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 57.67 E-value: 5.43e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1321042082 51 FSAAMPAMLTQTSLTAEDFAIMSSIFYILYGAMKFVGGMLVDKINPKA--MTGPVLIGVGIVniLFGFSDSVAAFYVLYS 128
Cdd:cd17355 22 FGVFIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRvmLLGLLLLAAGLV--LLALATSLWQLYLLWG 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1321042082 129 LNAILQ-GTSFPPMAKIMASWFSKNERGRWWAIVEAAHNIGGSLAPLLTSFAIAFSGsWKMGFYVPGAISLLMGIVALFT 207
Cdd:cd17355 100 LLGGGGaGTLAAVAFATVAAWWFERRRGLALGILTAGGGLGSLVFLPLGAALIEAFG-WRTALLVLALLALLVLVPVLLL 178
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 1321042082 208 IKDRPGTLGLPNVGQWRnDPTELAQVKASPVNLSFWQIFVKYILT 252
Cdd:cd17355 179 LRRRPADLALRAYDDAS-PASPGSTLKEALRSASFWLLALAFFLC 222
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
37-362 |
1.29e-08 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 56.40 E-value: 1.29e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1321042082 37 VFISYAVFYLTRKNFSAAMPAMLTQTSLTAEDFAIMSSIFYILYGAMKFVGGMLVDKINPKAMTGPVLIGVGIVNILFGF 116
Cdd:COG0738 13 IYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFAL 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1321042082 117 SDS----VAAFYVLYSLNAILQGTSFPpmakiMASWFSKNERGRWWAIVEAAHNIGGSLAPLLTSFAIA--FSGSWKMGF 190
Cdd:COG0738 93 APSypllLLALFLLGLGLGLLDVAANP-----YVAALGPETAASRLNLLHAFFSLGALLGPLLGGLLILlgLSLSWHLPY 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1321042082 191 YVPGAISLLMGIVALFTikdrpgtlglpNVGQWRNDPTELAQVKASPvnlsfwqifvKYILTNPLVWIIIIGDMSVYIAR 270
Cdd:COG0738 168 LILAVLLLLLALLFLRS-----------KLPEIEEEEEEAAGSAASL----------KSLLKNPRLLLGGLAIFLYVGAE 226
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1321042082 271 TILNDWPQIYYSQVHGWSLIKANSIISWFEAGGLAGGLLAGYLSDFmFKSNRWM-TGLIFALALCICIVLVPlvqdtSYT 349
Cdd:COG0738 227 GAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKR-FGPVRLLrLSALLAAVGLLLALLAP-----GPW 300
|
330
....*....|...
gi 1321042082 350 LTAILFTIMGFAL 362
Cdd:COG0738 301 LALIGLALVGLGL 313
|
|
| MFS_SLC37A1_2 |
cd17344 |
Solute carrier family 37 members 1 and 2 of the Major Facilitator Superfamily of transporters; ... |
30-213 |
1.38e-08 |
|
Solute carrier family 37 members 1 and 2 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 members 1 (SLC37A1) and 2 (SLC37A2) are also called sugar phosphate exchangers 1 (SPX1) and 2 (SPX2). SLC37A1 and SLC37A2 are ER-associated, Pi-linked antiporters that can transport glucose-6-phosphate (G6P) but are insensitive to chlorogenic acid, a competitive inhibitor of physiological ER G6P transport, unlike SLC37A4, the best characterized SLC37 family member and is the physiological G6P transporter (G6PT). SLC37A1 and SLC37A2 belong to the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340902 [Multi-domain] Cd Length: 400 Bit Score: 56.56 E-value: 1.38e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1321042082 30 RFEIIDSVFISYAVFYLTRK-----------NFSAAMPAMLTQTSLTA-------------EDFAIMSSIFYILYGAMKF 85
Cdd:cd17344 1 RGFILVLTFLAYACYHLSRKpisivksvlhpNCSALIPPPNIVLNNTTwcgwapfdgkngtELLGALDSAFLFAYAIGMF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1321042082 86 VGGMLVDKINPKAMTGPVLIGVGIVNILFGFS-----DSVAAFYVLYSLNAILQGTSFPPMAKIMASWFSKNERGRWWAI 160
Cdd:cd17344 81 FSGHIGERLPLRYFLSFGMLLSGLFTALFGLGyywniHSLWYFVVVQILAGLFQSTGWPSVVACVGNWFGKGKRGLIMGI 160
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....
gi 1321042082 161 VEAAHNIGGSLAPLLTsfAIAFSGSWKMGFYVPGAISLLMGIVA-LFTIKDRPG 213
Cdd:cd17344 161 WNSHTSVGNILGSLIA--GIFVSSAWGLSFIVPGIIIAAMGVLVfLFLVEHPPG 212
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
51-217 |
6.75e-08 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 53.66 E-value: 6.75e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1321042082 51 FSAAMPAMLTQTSLTAEDFAIMSSIFYILYGAMKFVGGMLVDKINPKAMTGPVLIGVGIVNILFGFSDSVAAFYVLYSLN 130
Cdd:COG0477 33 VNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLAPSPELLIAARALQ 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1321042082 131 AILQGTSFPPMAKIMASWFSKNERGRWWAIVEAAHNIGGSLAPLLTSFAIAFSGsWKMGFYVPGAISLLMGIVALFTIKD 210
Cdd:COG0477 113 GIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAALG-WRWIFLINAPLGLLALVLRLRLPES 191
|
....*..
gi 1321042082 211 RPGTLGL 217
Cdd:COG0477 192 RGLLLAL 198
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
37-206 |
8.01e-08 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 54.11 E-value: 8.01e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1321042082 37 VFISYAVFYLTRKNFSAAMPAMLTQT-SLTAEDFAIMSSIFYILYGAMKFVGGMLVDKINPKAMTGPVLIG--VGIVNIL 113
Cdd:cd17319 184 LALGYFGINYALYGLLTWLPTYLKQArGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLLRGARRLVIIIGllLAAVGLL 263
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1321042082 114 F-GFSDSVAAFYVLYSLNAILQGTSFPPMAKIMASWFSKNERGRWWAIVEAAHNIGGSLAPLLTSFAIAFSGSWKMGFYV 192
Cdd:cd17319 264 LaYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDATGSYTAAFLF 343
|
170
....*....|....
gi 1321042082 193 PGAISLLMGIVALF 206
Cdd:cd17319 344 LAAVALLAALLVLL 357
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
37-199 |
1.06e-07 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 53.78 E-value: 1.06e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1321042082 37 VFISYAVFYLTRKNFSAAMPAMLTQTSLTAEDFA-----------------------IMSSIFYiLYGAMKFVGGMLVDK 93
Cdd:cd17318 4 LFLGFAVVYAMRVNLSVAIVAMVNSTATHDNNNTstdkdtlpveapefdwsektqgiILSSFFY-GYILTQIPGGYLAEK 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1321042082 94 INPKAMTGPVLIGVGIVNIL--FGFSDSVAAFYVLYSLNAILQGTSFPPMAKIMASWFSKNERGRWWAIVEAAHNIGGSL 171
Cdd:cd17318 83 YGAKRVLGYSILITALLTLLtpLAARGGYGALIVLRILQGLAQGVTFPAMHALWAKWAPPLERSRLTSIAYSGSQFGTVI 162
|
170 180
....*....|....*....|....*...
gi 1321042082 172 APLLTSFaIAFSGSWKMGFYVPGAISLL 199
Cdd:cd17318 163 AMPLSGF-LCESLGWPSIFYIFGGLGLL 189
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
51-366 |
1.64e-07 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 52.94 E-value: 1.64e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1321042082 51 FSAAMPAMLTQTSLTAEDFAIMSSIFYILYGAMKFVGGMLVDKINPKAMT--GPVLIGVGIvnILFGFSDSVAAFYVLYS 128
Cdd:cd17478 15 LPALLPLLIAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLplGPLLTGLGL--SLLGFAPNYWLLLLLVA 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1321042082 129 LNAIlqGTS-FPPMAKIMASWFSKNERGRWWAIVEAAHNIGGSLAPLLTSFAIAFSGSwkMGFYVPGAISLLMGIVALFt 207
Cdd:cd17478 93 LAGI--GSAaFHPEGARLASQAAGGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGG--LGLLILLIIPGLAVALLLL- 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1321042082 208 ikdrpgtlglpnvgQWRNDPTELAQVKASPVNLSFWQIFVKYILTnpLVWIIIIGDMSVYIARTILndwpQIYYSQVHGW 287
Cdd:cd17478 168 --------------RLRPLKKPEAKKAAAKSSARSTLKGVWRALL--LLLIIVFLRSWVLSSLTTF----LPFYLVQRGY 227
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1321042082 288 SLIKANSIISWFEAGGLAGGLLAGYLSDfmfksnRWMTGLIFALALCICIVLVPLVQDTSYTLTAILFTIMGFALYGPH 366
Cdd:cd17478 228 SLVFAGLLLSLFLFAGAIGTLIGGPLSD------RFGRRRVIIASLLLAAPFLLLFLLTPGIWSYILLVLAGFLLFASF 300
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
51-424 |
3.64e-07 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 52.18 E-value: 3.64e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1321042082 51 FSAAMPAMLTQTSLTAEDFAIMSSIFYILYGAMKFVGGMLVDKINPK--AMTGPVLIGVGIVniLFGFSDSVAAFYVLYS 128
Cdd:COG2807 37 VGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRFGLErtLLLALLLLAAGLL--LRSLAPSVALLLAGTA 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1321042082 129 LNAILQGTSFPPMAKIMASWFSKNeRGRWWAIVEAAHNIGGSLAPLLTSFAIAfSGSWKMGFYVPGAISLLMGIVALFTI 208
Cdd:COG2807 115 LIGAGIAVGNVLLPGLIKRWFPDR-VGLMTGLYTAAMGLGAALAAGLTVPLAA-ALGWRGALAVWALLALLALLLWLPLL 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1321042082 209 KDRPGtlglpnvgqwrndPTELAQVKASPVNLsfwqifvkyiLTNPLVWIIIIGDMSVYIARTILNDW-PQIYYSqvHGW 287
Cdd:COG2807 193 RRRPA-------------AAAAAPAAASLRSL----------WRSPLAWLLTLFFGLQSLLYYAVVAWlPPILRD--AGL 247
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1321042082 288 SLIKANSIISWFEAGGLAGGLLAGYLSDFMfkSNRWMTGLIFALALCICIVLVPLVQDTSYTLTAILFTIMGFALYGPHM 367
Cdd:COG2807 248 SAATAGLLLSLFQLAGIPGSLLVPLLADRL--GDRRPLLLLLGLLGLAGLLGLLLAPGSLPWLWAVLLGLGQGGLFPLAL 325
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1321042082 368 LFAVgcLDVTHKDAAGSITGFRGLFSYVGAAMAgvPVIM-----VKNSWAWSGVYIYALIAI 424
Cdd:COG2807 326 TLIG--LRARTPAEAAALSGMAQSVGYLLAALG--PLLVgalhdATGSWTAALLLLAALAVL 383
|
|
| MFS_YjiJ |
cd06180 |
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of ... |
55-299 |
2.09e-06 |
|
Uncharacterized protein YjiJ and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Escherichia coli YjiJ and other uncharacterized proteins. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340869 [Multi-domain] Cd Length: 371 Bit Score: 49.61 E-value: 2.09e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1321042082 55 MPAMLTQTSLTAEDFAIMSSIFYILYGAMKFVGGMLVDKINPKAMtgpVLIGVGIVNILF---GFSDSVAAFYVLYSLNA 131
Cdd:cd06180 22 LPLMLAELGLSYAQAGWIATANYAGYLVGALLASFLRRRGRARRL---IRGGLLLTVLLLaamALTSGFAALLALRFLAG 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1321042082 132 ILQGTSFPPMAKIMASWFSKNERGRWWAIVEAAHNIGGSLAPLLTSFAIAFSGSWKMGFYVPGAISLLMGIVALFTIKDR 211
Cdd:cd06180 99 AASAFVFVFGSNLVLHHATAAGRGHLIGLLFAGVGLGIALSGLLVPAGLGGGLSWRAGWLALALLSAVLLLLSFLLLRRG 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1321042082 212 PGTLglpnvgqwrndPTELAQVKASPVNLSFWQIFVKYILTNpLVWIIIIGDMSVYIARTILNDWpqiyySQVHGWSLIK 291
Cdd:cd06180 179 PSAP-----------TEASAAESAPGLNRPLWRLALAYGLFG-FGYIITATFLPLIARETGAGSL-----LAGLLWSLFG 241
|
....*...
gi 1321042082 292 ANSIISWF 299
Cdd:cd06180 242 LAAVPSCF 249
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
56-207 |
1.18e-05 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 47.27 E-value: 1.18e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1321042082 56 PAMLTQTSLTAEDFAIMSSIFyilyGAMKFVG----GMLVDKINPKAMTGPVLIGVGIVNILFGFSDSVAAFYVLYS-LN 130
Cdd:cd17355 234 VPYLADRGISPAAAAVALALI----GLFNIVGrllsGWLGDRYSPRRLLAASYALRALGLALLLLLPFPPLALLLFAaLF 309
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1321042082 131 AILQGTSFPPMAKIMASWFSKNERGRWWAIVEAAHNIGGSLAPLLTSFAIAFSGSWKMGFYVPGAISLLMGIVALFT 207
Cdd:cd17355 310 GLGWGATVPLTAALAARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTGSYTAAWALAVALGLIAALLVLPI 386
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
36-212 |
1.86e-05 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 46.48 E-value: 1.86e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1321042082 36 SVFISYAVFYLtrknFSAAMPAMLTQTSLTAEDFAIMSSIFYILYGAMKFVGGMLVDKINPKAMTGPVLIGVGIVNILFG 115
Cdd:cd17341 7 SFFLGFMVWFL----FAPLGPVIRDDLGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRRVFIASLLLLLIPLLALA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1321042082 116 FSDSVAAFYVLYSLNAILQGTSFPPMAKIMASWFSKNERGRWWAIVEAAHNIGGSLAPLLT---SFAIAFSGS---WKMG 189
Cdd:cd17341 83 LAVSSYWGLLVLGFLLGFAGANFASGQPWASFWFPKEKIGGAAGGIAGAGNMGVAVSQLLApliAGAIVFDGGfvgWRNA 162
|
170 180
....*....|....*....|...
gi 1321042082 190 FYVPGAISLLMGIVALFTIKDRP 212
Cdd:cd17341 163 FFVPGILLAIAAVLVLLFGDDLP 185
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
9-205 |
7.26e-05 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 44.72 E-value: 7.26e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1321042082 9 SQPDKPIVKEKKKIDQTYKKFRFEIIDSVFISYAVFYLTRKNFSAAMPAMLTQT-SLTAEDFAIMSSIFYILYGAMKFVG 87
Cdd:cd06174 180 ARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLgGLSVAVAGLLLSLFGLAGALGSLLL 259
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1321042082 88 GMLVDK-INPKAMTGPVLIGVGIVNILFGFSDSVAAFYVLYSLNAILQGTSFPPMAKIMASWFSKNERGRWWAIVEAAHN 166
Cdd:cd06174 260 GLLSDRlIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGF 339
|
170 180 190
....*....|....*....|....*....|....*....
gi 1321042082 167 IGGSLAPLLTSFAIAFSGSWKMGFYVPGAISLLMGIVAL 205
Cdd:cd06174 340 LGGAIGPLLAGFLLAATFGLTGAFLVLAVLLLLAAILLL 378
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
55-206 |
1.06e-04 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 44.09 E-value: 1.06e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1321042082 55 MPAMLTQTSLTAEDFAIMSSIFYILYGAMKFVGGMLVDKINPK---AMTGPVLIGVGIVNILFGFSDSVAAFYVLYSlna 131
Cdd:COG2807 238 LPPILRDAGLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDRrplLLLLGLLGLAGLLGLLLAPGSLPWLWAVLLG--- 314
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1321042082 132 ILQGTSFPpMAKIMASWFSKNER--GRWWAIVEAAHNIGGSLAPLLTSFAIAFSGSWKMGFYVPGAISLLMGIVALF 206
Cdd:COG2807 315 LGQGGLFP-LALTLIGLRARTPAeaAALSGMAQSVGYLLAALGPLLVGALHDATGSWTAALLLLAALAVLMLVAGLL 390
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
37-207 |
1.45e-04 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 43.85 E-value: 1.45e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1321042082 37 VFISYAVFYLTRKNFSAAMPAMLTQTSLTAEDFAIMSSIFYILYGAMKFVGGMLVDKINPKAM--TGPVLIGVGIvnILF 114
Cdd:cd17333 1 LYISFFSNGLTDALLGILGPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTliLGLLLISLAL--ALI 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1321042082 115 GFSDSVAAFYVLYSLNAILQGTSFPPMAKIMASWFSKNeRGRWWAIVEAAHNIGGSLAPLLTSFAIAFSGSWKMGFYVPG 194
Cdd:cd17333 79 FATPSIYLFVVLMFLAGLGAGILDTGANTFVGALFEES-SATRLNVLHGFFGLGALIGPLIATSLLTSELSWSWAYLIIG 157
|
170
....*....|...
gi 1321042082 195 AISLLMGIVALFT 207
Cdd:cd17333 158 LIYLLLAILILLT 170
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
3-207 |
1.78e-04 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 43.33 E-value: 1.78e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1321042082 3 IKTFIFSQPDKPIVKEKKKIDQTYKKFRFEIIDSVFISYAVFYLTRKNFSAAMPAMLTQTSLTAED-----FAIMSsiFY 77
Cdd:cd17474 169 ILFLLPEPKEKAKSSSATKLRDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIiigllFAGWS--VL 246
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1321042082 78 ILYGAMkFVGGMLVDKINPKAMTGPVLIGVGIVNILFGFSDSVAAFYVLYSLNAILQGTSFPPMAKIMASWFSKNERGRW 157
Cdd:cd17474 247 LALGSL-FVGRLLKKRFGARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTA 325
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 1321042082 158 WAIVEAAHNIGGSLAPLLTSFaIAFSGSWKMGFYVPGAISLLMGIVALFT 207
Cdd:cd17474 326 SSLYNFVRFLGQAVGPLLFGL-LLEIFGLSAPFLVGAAIALAAAVLLALL 374
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
85-214 |
1.97e-04 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 43.37 E-value: 1.97e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1321042082 85 FVGGMLVDKINPKAM--TGPVLIGVGIvnILFGFSDSVAAFYVLYSLNAILQGTSFPPMAKIMASWFSKNERGRWWAIVE 162
Cdd:cd17329 53 LIGGRLADRFGRKPVmlAGLLLRALGF--ALLGFAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLY 130
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 1321042082 163 AAHNIGGSLAPLLTSFAIAFSGSWkmGFYVPGAISLLMGIVALFTIKDRPGT 214
Cdd:cd17329 131 WAINLGVAIGPLLGGLLLLYSFRL--LFLAAAVLFLLAALVLLFLLPETRPK 180
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
11-173 |
3.21e-04 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 42.79 E-value: 3.21e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1321042082 11 PDKPIVKEKKKIDQTYKKFRFEIIDSVFISYAVFYLTRKNFSAAMPAMLTQTSLTAEDFAIMSSIFYILYGAMKFVGGML 90
Cdd:pfam07690 179 RPKPAEEARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRL 258
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1321042082 91 VDKINPK---AMTGPVLIGVGIVNILFGFSDSVAAFYVLYSLNAILQGTSFPPMAKIMASWFSKNERGRWWAIVEAAHNI 167
Cdd:pfam07690 259 SDRLGRRrrlLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSL 338
|
....*.
gi 1321042082 168 GGSLAP 173
Cdd:pfam07690 339 GGALGP 344
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
152-402 |
5.22e-04 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 42.20 E-value: 5.22e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1321042082 152 NERGRWWAIVEAAHNIGGSLAPLLTSFAIAFSGS-----WKMGFYVPGAISLLMGIVALFTIKDRPgtlglpnvgqwrnd 226
Cdd:COG2211 143 EERTRLSSWRFAFAGLGGLLASVLPPPLVAAFGGdaalgYRLTALIFAVLGLLAFLLTFFGTKERP-------------- 208
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1321042082 227 ptelaqvKASPVNLSFWQIFvKYILTNPLVWIIIIGDMSVYIARTILNDWPQIYYSQVHGWSLIKANSIISWFEAGGLAG 306
Cdd:COG2211 209 -------VPEEEKVSLKESL-KALLKNRPFLLLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLG 280
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1321042082 307 GLLAGYLSDFMFKSNRWMTGLIFALALCICIVLVPLVQDTSYTLTAILFTI-MGFALYGPHMLFAvGCLDV----THKDA 381
Cdd:COG2211 281 APLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGPGNLWLLLVLAALAGIgLGAILVLPWAMLA-DVVDYdewkTGRRR 359
|
250 260
....*....|....*....|.
gi 1321042082 382 AGSITGFRGLFSYVGAAMAGV 402
Cdd:COG2211 360 EGLYFGIFTFAIKLGQALAGA 380
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
37-205 |
5.69e-04 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 41.82 E-value: 5.69e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1321042082 37 VFISYAVFYLtrknFSAAMPAMLTQT-SLTAEDFAIMSSIFYILYGAMKFVGGMLVDKINPKAMTGPVLIGVGIVNILFG 115
Cdd:cd17316 186 WFFISFGYYG----LTTFLPTYLQTVlGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLF 261
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1321042082 116 FSDSVAAFYVLYS--LNAILQGTSFPPMAKIMASWFSKNERGRWWAIVEAAHNIGGSLAPLLTSFAIAFSGSWKMGFYVP 193
Cdd:cd17316 262 YLLSGSPTLLLLLlfILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGVPALIL 341
|
170
....*....|..
gi 1321042082 194 GAISLLMGIVAL 205
Cdd:cd17316 342 ALLAIVALIVAL 353
|
|
| MFS_SLC17A5 |
cd17381 |
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of ... |
38-199 |
5.93e-04 |
|
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of transporters; Solute carrier family 17 member 5 (SLC17A5) is also called sialin, H(+)/nitrate cotransporter, H(+)/sialic acid cotransporter (AST), membrane glycoprotein HP59, or vesicular H(+)/aspartate-glutamate cotransporter. It transports glucuronic acid and free sialic acid out of the lysosome after its cleavage from sialoglycoconjugates, which is required for normal CNS myelination. It also mediates the membrane potential-dependent uptake of aspartate and glutamate into synaptic vesicles and synaptic-like microvesicles. In the plasma membrane, it functions as a nitrate transporter. Recessive mutations in the SLC17A5 gene cause the allelic disorders, Infantile sialic acid storage disease (ISSD) and Salla disease (a predominantly neurological disorder). SLC17A5 belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340939 [Multi-domain] Cd Length: 397 Bit Score: 42.07 E-value: 5.93e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1321042082 38 FISYAVFYLTRKNFSAAMPAMLTQTSLTAEDFA-------------------------------IMSSIFYiLYGAMKFV 86
Cdd:cd17381 6 FFGFFVVYALRVNLSVALVDMVNSNSTLPSNNSsnacpehssspsvehnetgkkydwdaetqgwILGSFFY-GYIITQIP 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1321042082 87 GGMLVDKINPKAMTGPVLIGVGIVNILFGFSDSVAAFY--VLYSLNAILQGTSFPPMAKIMASWFSKNERGRWWAIVEAA 164
Cdd:cd17381 85 GGYLASKIGGKLLLGFGILGTAVFTLLTPLAADLGAGYliAVRALEGLGEGVTFPAMHAMWASWAPPLERSRLLTISYAG 164
|
170 180 190
....*....|....*....|....*....|....*
gi 1321042082 165 HNIGGSLAPLLTSFaIAFSGSWKMGFYVPGAISLL 199
Cdd:cd17381 165 AQLGTVVSLPLSGL-ICYYLDWTYVFYIFGAVGLL 198
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
71-208 |
6.67e-04 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 41.57 E-value: 6.67e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1321042082 71 IMSS-IFYILYGAmkFVGGMLVDKINPKAMTGPVLIGVGIVNILFGFSDSVAAFYVLYSLNAILQGTSFPPMAKIMASWF 149
Cdd:TIGR00895 57 LFSAgLIGMAFGA--LFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLILRFLAGLGLGGLMPNLNALVSEYA 134
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 1321042082 150 SKNERGRWWAIVEAAHNIGGSLAPLLTSFAIAFSGsWKMGFYVPGAISLLMGIVALFTI 208
Cdd:TIGR00895 135 PKRFRGTAVGLMFCGYPIGAAVGGFLAGWLIPVFG-WRSLFYVGGIAPLLLLLLLMRFL 192
|
|
| 2A0108 |
TIGR00886 |
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions] |
38-212 |
1.02e-03 |
|
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions]
Pssm-ID: 273322 [Multi-domain] Cd Length: 354 Bit Score: 41.13 E-value: 1.02e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1321042082 38 FISYAVFYLtrknFSAAMPAMLTQT-SLTAEDFAIMSSIFYILYGAMKFVGGMLVDKINPKAMTGPVLIGVGIVNILFGF 116
Cdd:TIGR00886 11 FLSFLVWFA----FSPLAVFLIKDDlGLSTAQLGNLVAVPVLAGAVLRIILGFLVDIFGPRYTTALSLLLLAIPCLWAGL 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1321042082 117 SDSVAAFYVLYSLNAILQGTSFPPMAKIMASWFSKNERGRWWAIVEAAHNIGGSLA----PLLTSFAIAFSG-----SWK 187
Cdd:TIGR00886 87 AVQSYSVLLLIRLFIGIAGGSFASCMPWISFFFPKKIQGTALGLAAGWGNMGGGVAqfvmPPIIGSLIFGGGqpahlAWG 166
|
170 180
....*....|....*....|....*.
gi 1321042082 188 MGFY-VPGAISLLMGIVALFTIKDRP 212
Cdd:TIGR00886 167 WAFViVPAGILLLPALLIFFVGADTP 192
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
51-212 |
1.13e-03 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 41.06 E-value: 1.13e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1321042082 51 FSAAMPAMLTQTSLTAEDFAIMSSIFYILYGAMKFVGGMLVDKINPK--AMTGPVLIGVGIvnILFGFSDSVAAFYVLYS 128
Cdd:cd17353 22 WSVFNPPLSSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRkaILIGGILFGLGF--ILSAFAISLPLLFLGYG 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1321042082 129 L-----NAILQGTSFPPMAKimasWFSKNeRGRWWAIVEAAHNIGGSLAPLLTSFAIAFSGSWKMgFYVPGAISLLMGIV 203
Cdd:cd17353 100 VlggigAGIGYITPVSTAVK----WFPDK-RGLATGIVIAGFGLGSLIFSPLIAYLINTVGVPTT-FLILGIIFLIIIVI 173
|
....*....
gi 1321042082 204 ALFTIKDRP 212
Cdd:cd17353 174 GAFLIRDPP 182
|
|
| 2A0114euk |
TIGR00894 |
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions] |
71-401 |
2.11e-03 |
|
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
Pssm-ID: 129972 [Multi-domain] Cd Length: 465 Bit Score: 40.11 E-value: 2.11e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1321042082 71 IMSSIFYiLYGAMKFVGGMLVDKINPKAMTGPVLIGVGIVNILFGFS--DSVAAFYVLYSLNAILQGTSFPPMAKIMASW 148
Cdd:TIGR00894 81 ILSSHFY-GQIIIQIPVGYLAGKYVFKWSIGIGMFLSSVISIVIPWAagGGIALVVFCRVIQGLAQGSVSPATHKIIVKW 159
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1321042082 149 FSKNERGRWWAIVEAAHNIGGSLAPLLTSFAIAFSGSWKMGFYVPGAISLLMGIVALFTIKDRPgtlglpnvgqwRNDPT 228
Cdd:TIGR00894 160 APPKERSRLLGMSTSGFQLGTFIFLPISGWLCESWGGWPMIFYVFGIVGCAWSLLWFVFPADDP-----------SIHPC 228
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1321042082 229 ELAQVKASpVNLSFWQ--------IFVKYILTNPLVWIIIIGDMSVYIARTILNDWPQIYYSQVHGWSlIKANSIISWFE 300
Cdd:TIGR00894 229 ISKFEKKY-INSSLQGqkgstrqsLPIKAIPKSLPVWAIWFAIFGHFWLYTILPTYLPTFISWVLRVS-GKENGLLSSLP 306
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1321042082 301 AGGL-AGGLLAGYLSDFMFKSNRWMTGLI-----FALALCICIVLVPLVQDTSYTLTAILFTIMGFALYGphmlFAVGCL 374
Cdd:TIGR00894 307 YLFAwLCSIFAGYLADFLKSSKTLSLTAArkifnGIGGLGPGIFAYALPYLSAAFYLTIIILTLANAVSS----GPLAGV 382
|
330 340
....*....|....*....|....*..
gi 1321042082 375 DVTHKDAAGSITGFRGLFSYVGAAMAG 401
Cdd:TIGR00894 383 LINSLDLAPRFLGFIKGITGLPGFIGG 409
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
36-212 |
4.10e-03 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 39.11 E-value: 4.10e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1321042082 36 SVFISYAVFYLtrknFSAAMPAMLTQTSLTAEDFAIMSSIFYILYGAMKFVGGMLVDKINPKAMTGPVLIGVGIVNILFG 115
Cdd:cd17489 4 ANFFFFLSFYL----LLPVLPLYAHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1321042082 116 FSDSVAAFYVLYSLNAILQGTSFPPMAKIMASWFSKNERGRWWAIVEAAHNIGGSLAPLLTSFAIAFSGSWkMGFYVPGA 195
Cdd:cd17489 80 LATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFA-VLFIVAAV 158
|
170
....*....|....*..
gi 1321042082 196 ISLLmGIVALFTIKDRP 212
Cdd:cd17489 159 LALL-ALLLVFLVKDPP 174
|
|
| MFS_ShiA_like |
cd17369 |
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This ... |
37-206 |
8.04e-03 |
|
Shikimate transporter and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli shikimate transporter (ShiA), inner membrane metabolite transport protein YhjE, and other putative metabolite transporters. ShiA is involved in the uptake of shikimate, an aromatic compound involved in siderophore biosynthesis. It has been suggested that YhjE may mediate the uptake of osmoprotectants. The ShiA-like subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340927 [Multi-domain] Cd Length: 408 Bit Score: 38.28 E-value: 8.04e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1321042082 37 VFISYAVFYLTrknfsaampamlTQTSLTAEDFAIMSSIFYILYGAMKFVGGMLVDKINPKamtgPVLIGVGIVNILFGF 116
Cdd:cd17369 246 LFTTFALSYAT------------QTLGVDRSTVLLAVLIASVVAAITIPLFGWLSDRVGRR----PVYLAGALLAALFAF 309
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1321042082 117 --------SDSVAAFYVLYSLNAILQGTSFPPMAKIMASWFSKNERGRWWAIV-EAAHNIGGSLAPLLTSFAIAFSGSWK 187
Cdd:cd17369 310 pffwlldtGSTWLIVLAAVVVLGVLHGMMYGPQAAFLAELFPTRVRYTGASLGyQLGAILGGGFAPLIATALVAATGSWW 389
|
170
....*....|....*....
gi 1321042082 188 MGFYVPGAISLLMGIVALF 206
Cdd:cd17369 390 PVALYLAALAVISLVAALF 408
|
|
| |
