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Conserved domains on  [gi|1340274858|gb|AUZ84078|]
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hypothetical protein CDW43_05600 [Methylophaga nitratireducenticrescens]

Protein Classification

YfgM family protein( domain architecture ID 11459477)

YfgM family protein is a tetratricopeptide repeat protein similar to Escherichia coli Ancillary SecYEG translocon subunit that may mediate protein transfer from the SecYEG translocon to the periplasmic chaperone network via its periplasmic C-terminal region

CATH:  1.25.40.10
Gene Ontology:  GO:0005515|GO:0044877
PubMed:  22404999|21153002|10517866|30708253
SCOP:  4001344
TCDB:  3.A.5

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
YfgM COG2976
Putative negative regulator of RcsB-dependent stress response, UPF0070 family [Signal ...
 1-206 9.86e-68

Putative negative regulator of RcsB-dependent stress response, UPF0070 family [Signal transduction mechanisms];


:

Pssm-ID: 442215 [Multi-domain]  Cd Length: 207  Bit Score: 206.63  E-value: 9.86e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1340274858   1 MDIYASDDEKGEAIKSWWRENGRSVITGVILGGAVIFGGRYWINFQQAKTENAAAMYQQVQMTISQADLTAAEDMTQELM 80
Cdd:COG2976     1 MAYYLTEEEQLEAIKKWWKENGKAIIVGVVLGLAAVFGWRYWQSYQESQAEEASALYEQLLEALAAGDAAAAAAAAEKLI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1340274858  81 QSYPSTPYAAFATLELAAEQLRNDQAEAALEYLSWTADKAKLSAQKDLARLRMARVLMDQGKYDQAFELTQQTVSDGFVS 160
Cdd:COG2976    81 DDYGGTAYAALAALLLAKAAVDAGDLDKAAAQLQWVLDNAKDPALKALARLRLARVLLAQKKYDEALATLDAVKPEAFAA 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 1340274858 161 LFAEVQGDIYLAQEKQTQAYEAYVEAISTMNMDDPRKTLLEMKRDD 206
Cdd:COG2976   161 LYAELRGDILLAQGDKAEARAAYQKALAALPEDAPLRQLLQMKLDD 206
 
Name Accession Description Interval E-value
YfgM COG2976
Putative negative regulator of RcsB-dependent stress response, UPF0070 family [Signal ...
 1-206 9.86e-68

Putative negative regulator of RcsB-dependent stress response, UPF0070 family [Signal transduction mechanisms];


Pssm-ID: 442215 [Multi-domain]  Cd Length: 207  Bit Score: 206.63  E-value: 9.86e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1340274858   1 MDIYASDDEKGEAIKSWWRENGRSVITGVILGGAVIFGGRYWINFQQAKTENAAAMYQQVQMTISQADLTAAEDMTQELM 80
Cdd:COG2976     1 MAYYLTEEEQLEAIKKWWKENGKAIIVGVVLGLAAVFGWRYWQSYQESQAEEASALYEQLLEALAAGDAAAAAAAAEKLI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1340274858  81 QSYPSTPYAAFATLELAAEQLRNDQAEAALEYLSWTADKAKLSAQKDLARLRMARVLMDQGKYDQAFELTQQTVSDGFVS 160
Cdd:COG2976    81 DDYGGTAYAALAALLLAKAAVDAGDLDKAAAQLQWVLDNAKDPALKALARLRLARVLLAQKKYDEALATLDAVKPEAFAA 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 1340274858 161 LFAEVQGDIYLAQEKQTQAYEAYVEAISTMNMDDPRKTLLEMKRDD 206
Cdd:COG2976   161 LYAELRGDILLAQGDKAEARAAYQKALAALPEDAPLRQLLQMKLDD 206
TPR_21 pfam09976
Tetratricopeptide repeat-like domain; This family resembles a single unit of a TPR repeat.
 15-209 1.91e-55

Tetratricopeptide repeat-like domain; This family resembles a single unit of a TPR repeat.


Pssm-ID: 430959 [Multi-domain]  Cd Length: 194  Bit Score: 174.70  E-value: 1.91e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1340274858  15 KSWWRENGRSVITGVILGGAVIFGGRYWINFQQAKTENAAAMYQQVQMTISQADLTAAEDMTQELMQSYPSTPYAAFATL 94
Cdd:pfam09976   1 KAWWKENGKLIIIGVVIGLGGLFGWNGWQYYQRSQAEEASALYQQLLEAVAAGDAAKAQAAAAQLKDEYGGTGYAALAAL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1340274858  95 ELAAEQLRNDQAEAALEYLSWTADKAKLSAQKDLARLRMARVLMDQGKYDQAFELTQQTVSDGFVSLFAEVQGDIYLAQE 174
Cdd:pfam09976  81 LLAKAAVEAGDLAAAKAQLEWVADNAKDEALKALARLRLARVLLAQGKYDEALKTLDAVTPAAFAALYAELRGDILVAQG 160

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1340274858 175 KQTQAYEAYVEAISTMNMDDPRKtLLEMKRDDVAV 209
Cdd:pfam09976 161 KTDEARAAYQAALDALDAGAPRP-LLQMKLDDLGG 194
PRK11788 PRK11788
tetratricopeptide repeat protein; Provisional
 95-181 9.16e-04

tetratricopeptide repeat protein; Provisional


Pssm-ID: 236983 [Multi-domain]  Cd Length: 389  Bit Score: 39.41  E-value: 9.16e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1340274858  95 ELAAEQLRNDQAEAALEYLswtaDKAkLSAQKDLAR--LRMARVLMDQGKYDQAFELTQQ--TVSDGFVSLFAEVQGDIY 170
Cdd:PRK11788  185 ELAQQALARGDLDAARALL----KKA-LAADPQCVRasILLGDLALAQGDYAAAIEALERveEQDPEYLSEVLPKLMECY 259

                          90
                  ....*....|.
gi 1340274858 171 LAQEKQTQAYE 181
Cdd:PRK11788  260 QALGDEAEGLE 270
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 44-187 1.55e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 38.91  E-value: 1.55e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1340274858  44 NFQQAKTENAAAMYQQVQMTISQADLTAAE-DMTQELMQSYPST---PYAAFA---------TLELAAEQ--LRNDQAEA 108
Cdd:TIGR02917  47 NALQKDPNDAEARFLLGKIYLALGDYAAAEkELRKALSLGYPKNqvlPLLARAyllqgkfqqVLDELPGKtlLDDEGAAE 126

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1340274858 109 ALEYLSWTA------DKAK---LSAQKD-----LARLRMARVLMDQGKYDQAFELTQQ--TVSDGFVSLFAeVQGDIYLA 172
Cdd:TIGR02917 127 LLALRGLAYlglgqlELAQksyEQALAIdprslYAKLGLAQLALAENRFDEARALIDEvlTADPGNVDALL-LKGDLLLS 205

                         170
                  ....*....|....*
gi 1340274858 173 QEKQTQAYEAYVEAI 187
Cdd:TIGR02917 206 LGNIELALAAYRKAI 220
 
Name Accession Description Interval E-value
YfgM COG2976
Putative negative regulator of RcsB-dependent stress response, UPF0070 family [Signal ...
 1-206 9.86e-68

Putative negative regulator of RcsB-dependent stress response, UPF0070 family [Signal transduction mechanisms];


Pssm-ID: 442215 [Multi-domain]  Cd Length: 207  Bit Score: 206.63  E-value: 9.86e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1340274858   1 MDIYASDDEKGEAIKSWWRENGRSVITGVILGGAVIFGGRYWINFQQAKTENAAAMYQQVQMTISQADLTAAEDMTQELM 80
Cdd:COG2976     1 MAYYLTEEEQLEAIKKWWKENGKAIIVGVVLGLAAVFGWRYWQSYQESQAEEASALYEQLLEALAAGDAAAAAAAAEKLI 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1340274858  81 QSYPSTPYAAFATLELAAEQLRNDQAEAALEYLSWTADKAKLSAQKDLARLRMARVLMDQGKYDQAFELTQQTVSDGFVS 160
Cdd:COG2976    81 DDYGGTAYAALAALLLAKAAVDAGDLDKAAAQLQWVLDNAKDPALKALARLRLARVLLAQKKYDEALATLDAVKPEAFAA 160

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 1340274858 161 LFAEVQGDIYLAQEKQTQAYEAYVEAISTMNMDDPRKTLLEMKRDD 206
Cdd:COG2976   161 LYAELRGDILLAQGDKAEARAAYQKALAALPEDAPLRQLLQMKLDD 206
TPR_21 pfam09976
Tetratricopeptide repeat-like domain; This family resembles a single unit of a TPR repeat.
 15-209 1.91e-55

Tetratricopeptide repeat-like domain; This family resembles a single unit of a TPR repeat.


Pssm-ID: 430959 [Multi-domain]  Cd Length: 194  Bit Score: 174.70  E-value: 1.91e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1340274858  15 KSWWRENGRSVITGVILGGAVIFGGRYWINFQQAKTENAAAMYQQVQMTISQADLTAAEDMTQELMQSYPSTPYAAFATL 94
Cdd:pfam09976   1 KAWWKENGKLIIIGVVIGLGGLFGWNGWQYYQRSQAEEASALYQQLLEAVAAGDAAKAQAAAAQLKDEYGGTGYAALAAL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1340274858  95 ELAAEQLRNDQAEAALEYLSWTADKAKLSAQKDLARLRMARVLMDQGKYDQAFELTQQTVSDGFVSLFAEVQGDIYLAQE 174
Cdd:pfam09976  81 LLAKAAVEAGDLAAAKAQLEWVADNAKDEALKALARLRLARVLLAQGKYDEALKTLDAVTPAAFAALYAELRGDILVAQG 160

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1340274858 175 KQTQAYEAYVEAISTMNMDDPRKtLLEMKRDDVAV 209
Cdd:pfam09976 161 KTDEARAAYQAALDALDAGAPRP-LLQMKLDDLGG 194
TPR1 COG4649
TPR-like repeat domain [Function unknown];
12-145 1.87e-10

TPR-like repeat domain [Function unknown];


Pssm-ID: 443687 [Multi-domain]  Cd Length: 222  Bit Score: 58.34  E-value: 1.87e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1340274858  12 EAIKSWWRENGRSVITGVILGGAVIFGGRYWINFQQAKTENAAAMYQQVQMTISQADLTAAEDMTQELMQSYPStPYAAF 91
Cdd:COG4649    18 DRLRALWRRYGPWIIGAAVLVVVGVAGWRGWRYWQEAQAEAAGDAYLAALELAEAGDAAEAAAALAALAADGPG-GYAAL 96

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1340274858  92 ATLELAAEQLRNDQAEAALEYLSWTADKAKLSAQ-KDLARLRMARVLMDQGKYDQ 145
Cdd:COG4649    97 ARLRAAALLAQAGDTAAAVAAYDAVAADASAPPLlRDLARLRAALLLVDTGDPAD 151
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 51-187 1.22e-06

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 47.80  E-value: 1.22e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1340274858  51 ENAAAMYQQVQMTISQADLTAAEDMTQELMQSYPSTPYAAFATLELAAEQLRNDQAEAALEYLswtadkAKLSAQKDLAR 130
Cdd:COG2956    74 DRAEALLELAQDYLKAGLLDRAEELLEKLLELDPDDAEALRLLAEIYEQEGDWEKAIEVLERL------LKLGPENAHAY 147

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1340274858 131 LRMARVLMDQGKYDQAFELTQQ--TVSDGFVSLFAEvQGDIYLAQEKQTQAYEAYVEAI 187
Cdd:COG2956   148 CELAELYLEQGDYDEAIEALEKalKLDPDCARALLL-LAELYLEQGDYEEAIAALERAL 205
CpoB COG1729
Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane ...
 66-156 4.54e-05

Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441335 [Multi-domain]  Cd Length: 113  Bit Score: 41.13  E-value: 4.54e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1340274858  66 QADLTAAEDMTQELMQSYPSTPYAAFATLELAAEQLRNDQAEAALEYLSWTADKAKLSAQKDLARLRMARVLMDQGKYDQ 145
Cdd:COG1729     6 AGDYDEAIAAFKAFLKRYPNSPLAPDALYWLGEAYYALGDYDEAAEAFEKLLKRYPDSPKAPDALLKLGLSYLELGDYDK 85

                          90
                  ....*....|.
gi 1340274858 146 AFELTQQTVSD 156
Cdd:COG1729    86 ARATLEELIKK 96
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 50-188 7.25e-05

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 41.33  E-value: 7.25e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1340274858  50 TENAAAMYQQVQMTISQADLTAAEDMTQELMQSYPSTPYAAFATLELAAEQLRNDQAEAALEYLswtadkAKLSAQKDLA 129
Cdd:COG4783     1 AACAEALYALAQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEA------LELDPDEPEA 74

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1340274858 130 RLRMARVLMDQGKYDQAFELTQQTVSDGFVSLFAEVQ-GDIYLAQEKQTQAYEAYVEAIS 188
Cdd:COG4783    75 RLNLGLALLKAGDYDEALALLEKALKLDPEHPEAYLRlARAYRALGRPDEAIAALEKALE 134
PRK11788 PRK11788
tetratricopeptide repeat protein; Provisional
 95-181 9.16e-04

tetratricopeptide repeat protein; Provisional


Pssm-ID: 236983 [Multi-domain]  Cd Length: 389  Bit Score: 39.41  E-value: 9.16e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1340274858  95 ELAAEQLRNDQAEAALEYLswtaDKAkLSAQKDLAR--LRMARVLMDQGKYDQAFELTQQ--TVSDGFVSLFAEVQGDIY 170
Cdd:PRK11788  185 ELAQQALARGDLDAARALL----KKA-LAADPQCVRasILLGDLALAQGDYAAAIEALERveEQDPEYLSEVLPKLMECY 259

                          90
                  ....*....|.
gi 1340274858 171 LAQEKQTQAYE 181
Cdd:PRK11788  260 QALGDEAEGLE 270
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 47-187 1.00e-03

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 38.94  E-value: 1.00e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1340274858  47 QAKTENAAAMYQQVQMTISQADLTAAEDMTQELMQSYPSTPYAAFATLELAAEQLRNDQAEAALEylswtaDKAKLSAQK 126
Cdd:COG2956   138 KLGPENAHAYCELAELYLEQGDYDEAIEALEKALKLDPDCARALLLLAELYLEQGDYEEAIAALE------RALEQDPDY 211

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1340274858 127 DLARLRMARVLMDQGKYDQAFELTQQTVSDGFVSLFAEVQGDIYLAQEKQTQAYEAYVEAI 187
Cdd:COG2956   212 LPALPRLAELYEKLGDPEEALELLRKALELDPSDDLLLALADLLERKEGLEAALALLERQL 272
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 40-202 1.40e-03

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 38.56  E-value: 1.40e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1340274858  40 RYWINFQQAKTENAAAMYQQVQMTISQADLTAAEDMTQELMQSYPSTPYAAFATLELAAEQLRNDQAEAALEYLswtadk 119
Cdd:COG2956    97 ELLEKLLELDPDDAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPENAHAYCELAELYLEQGDYDEAIEALEKA------ 170

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1340274858 120 akLSAQKDLARLRM--ARVLMDQGKYDQAFELTQQTV--SDGFVSLFAEVqGDIYLAQEKQTQAYEAYVEAISTMNMDDP 195
Cdd:COG2956   171 --LKLDPDCARALLllAELYLEQGDYEEAIAALERALeqDPDYLPALPRL-AELYEKLGDPEEALELLRKALELDPSDDL 247


                  ....*..
gi 1340274858 196 RKTLLEM 202
Cdd:COG2956   248 LLALADL 254
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 44-187 1.55e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 38.91  E-value: 1.55e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1340274858  44 NFQQAKTENAAAMYQQVQMTISQADLTAAE-DMTQELMQSYPST---PYAAFA---------TLELAAEQ--LRNDQAEA 108
Cdd:TIGR02917  47 NALQKDPNDAEARFLLGKIYLALGDYAAAEkELRKALSLGYPKNqvlPLLARAyllqgkfqqVLDELPGKtlLDDEGAAE 126

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1340274858 109 ALEYLSWTA------DKAK---LSAQKD-----LARLRMARVLMDQGKYDQAFELTQQ--TVSDGFVSLFAeVQGDIYLA 172
Cdd:TIGR02917 127 LLALRGLAYlglgqlELAQksyEQALAIdprslYAKLGLAQLALAENRFDEARALIDEvlTADPGNVDALL-LKGDLLLS 205

                         170
                  ....*....|....*
gi 1340274858 173 QEKQTQAYEAYVEAI 187
Cdd:TIGR02917 206 LGNIELALAAYRKAI 220
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 71-187 2.10e-03

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 38.17  E-value: 2.10e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1340274858  71 AAEDMTQELMQSYPSTPYAAFATLELAAEQLRNDQAEAALEYLswtadkAKLSAQKDLARLRMARVLMDQGKYDQAFELT 150
Cdd:COG2956    26 KAIDLLEEALELDPETVEAHLALGNLYRRRGEYDRAIRIHQKL------LERDPDRAEALLELAQDYLKAGLLDRAEELL 99

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1340274858 151 QQTVS-DGFVSLFAEVQGDIYLAQEKQTQAYEAYVEAI 187
Cdd:COG2956   100 EKLLElDPDDAEALRLLAEIYEQEGDWEKAIEVLERLL 137
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 87-189 2.26e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 38.53  E-value: 2.26e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1340274858  87 PYAAFATLELAAEQLRNDQAEAALEYLswtadKAKLSAQKDL--ARLRMARVLMDQGKYDQAF----ELTQQTVSDGFVS 160
Cdd:TIGR02917 632 PDSALALLLLADAYAVMKNYAKAITSL-----KRALELKPDNteAQIGLAQLLLAAKRTESAKkiakSLQKQHPKAALGF 706

                          90       100
                  ....*....|....*....|....*....
gi 1340274858 161 lfaEVQGDIYLAQEKQTQAYEAYVEAIST 189
Cdd:TIGR02917 707 ---ELEGDLYLRQKDYPAAIQAYRKALKR 732
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 41-188 4.26e-03

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 37.40  E-value: 4.26e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1340274858  41 YWINFQQAKTENAAAMYQQVQMTISQADLTAAEDMTQELMQSYPSTPYAAFATLELAAEQLRNDQAEAALEYLswtadkA 120
Cdd:COG2956    30 LLEEALELDPETVEAHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAEALLELAQDYLKAGLLDRAEELLEKL------L 103

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1340274858 121 KLSAQKDLARLRMARVLMDQGKYDQAFELTQQTVSDGFVSLFAEVQ-GDIYLAQEKQTQAYEAYVEAIS 188
Cdd:COG2956   104 ELDPDDAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPENAHAYCElAELYLEQGDYDEAIEALEKALK 172
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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