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Conserved domains on  [gi|1342388664|gb|AVB05042|]
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Secreted effector protein SseI [Salmonella enterica]

Protein Classification

SPI-2 type III secretion system effector E3 ubiquitin transferase SspH2( domain architecture ID 11487764)

SPI-2 type III secretion system effector E3 ubiquitin transferase SspH2 is an E3 ubiquitin ligase that interferes with host's ubiquitination pathway

CATH:  3.80.10.10
EC:  2.3.2.27
Gene Ontology:  GO:0016567|GO:0004842|GO:0030254|GO:0061630
SCOP:  4003209

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
1-788 0e+00

type III secretion system effector E3 ubiquitin transferase SspH2;


:

Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 1607.52  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1342388664   1 MPFHIGSGCLPATISNRRIYRIAWSDTPPEMSSWEKMKEFFCSTHQTEALECIWTICHPPAGTTREDVVSRFELLRTLAY 80
Cdd:PRK15387    1 MPFHIGSGCLPATISNRRIYRIAWSDTPPEMSSWEKMKEFFCSTHQTEALECIWTICHPPAGTTREDVINRFELLRTLAY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1342388664  81 AGWEESIHSGQHGENYFCILDEDSQEILSVTLDDAGNYTVNCQGYSETHRLTLDTAQGEEGTGHAEGASGTFRTSFLPAT 160
Cdd:PRK15387   81 AGWEESIHSGQHGENYFCILDEDSQEILSVTLDDAGNYTVNCQGYSETHRLTLDTAQGEEGTGHAEGASGTFRTSFLPAT 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1342388664 161 TAPQTPAEYDAVWSAWRRAAPAEESRGRAAVVQKMRACLNNGNAVLNVGESGLTTLPDCLPAHITTLVIPDNNLTSLPAL 240
Cdd:PRK15387  161 TAPQTPAEYDAVWSAWRRAAPAEESRGRAAVVQKMRACLNNGNAVLNVGESGLTTLPDCLPAHITTLVIPDNNLTSLPAL 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1342388664 241 PPELRTLEVSGNQLTSLPVLPPGLLELSIFSNPLTHLPALPSGLCKLWIFGNQLTSLPVLPPGLQELSVSDNQLASLPAL 320
Cdd:PRK15387  241 PPELRTLEVSGNQLTSLPVLPPGLLELSIFSNPLTHLPALPSGLCKLWIFGNQLTSLPVLPPGLQELSVSDNQLASLPAL 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1342388664 321 PSELCKLWAYNNQLTSLPTLPSGLQELSVSDNQLASLPTLPSELYKLWAYNNRLTSLPALPSGLKELIVSGNRLTSLPVL 400
Cdd:PRK15387  321 PSELCKLWAYNNQLTSLPTLPSGLQELSVSDNQLASLPTLPSELYKLWAYNNRLTSLPALPSGLKELIVSGNRLTSLPVL 400

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1342388664 401 PSELKELMVSGNRLTSLPMLPSGLLSLSVYRNQLTRLPESLIHLSSETTVNLEGNPLSERTLQALREITSAPGYSGPIIQ 480
Cdd:PRK15387  401 PSELKELMVSGNRLTSLPMLPSGLLSLSVYRNQLTRLPESLIHLSSETTVNLEGNPLSERTLQALREITSAPGYSGPIIR 480

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1342388664 481 FDMAGASAPRETRALHLAAADWLVPAREGEPAPADRWHMFGQEDNADAFSLFLDRLSETENFIKDAGFKAQISSWLAQLA 560
Cdd:PRK15387  481 FDMAGASAPRETRALHLAAADWLVPAREGEPAPADRWHMFGQEDNADAFSLFLDRLSETENFIKDAGFKAQISSWLAQLA 560

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1342388664 561 EDEALRANTFAMATEATSSCEDRVTFFLHQMKNVQLVHNAEKGQYDNDLAALVATGREMFRLGKLEQIAREKVRTLALVD 640
Cdd:PRK15387  561 EDEALRANTFAMATEATSSCEDRVTFFLHQMKNVQLVHNAEKGQYDNDLAALVATGREMFRLGKLEQIAREKVRTLALVD 640

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1342388664 641 EIEVWLAYQNKLKKSLGLTSVTAEMRFFDVSGVTVTDLQDAELQVKAAEKSEFREWILQWGPLHRVLERKAPERVNALRE 720
Cdd:PRK15387  641 EIEVWLAYQNKLKKSLGLTSVTSEMRFFDVSGVTVTDLQDAELQVKAAEKSEFREWILQWGPLHRVLERKAPERVNALRE 720

                         730       740       750       760       770       780
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1342388664 721 KQISDYEETYRMLSDTELRPSGLVGNTDAERTIGARAMESAKKTFLDGLRPLVEEMLGSYLNVQWRRN 788
Cdd:PRK15387  721 KQISDYEETYRMLSDTELRPSGLVGNTDAERTIGARAMESAKKTFLDGLRPLVEEMLGSYLNVQWRRN 788
 
Name Accession Description Interval E-value
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
1-788 0e+00

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 1607.52  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1342388664   1 MPFHIGSGCLPATISNRRIYRIAWSDTPPEMSSWEKMKEFFCSTHQTEALECIWTICHPPAGTTREDVVSRFELLRTLAY 80
Cdd:PRK15387    1 MPFHIGSGCLPATISNRRIYRIAWSDTPPEMSSWEKMKEFFCSTHQTEALECIWTICHPPAGTTREDVINRFELLRTLAY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1342388664  81 AGWEESIHSGQHGENYFCILDEDSQEILSVTLDDAGNYTVNCQGYSETHRLTLDTAQGEEGTGHAEGASGTFRTSFLPAT 160
Cdd:PRK15387   81 AGWEESIHSGQHGENYFCILDEDSQEILSVTLDDAGNYTVNCQGYSETHRLTLDTAQGEEGTGHAEGASGTFRTSFLPAT 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1342388664 161 TAPQTPAEYDAVWSAWRRAAPAEESRGRAAVVQKMRACLNNGNAVLNVGESGLTTLPDCLPAHITTLVIPDNNLTSLPAL 240
Cdd:PRK15387  161 TAPQTPAEYDAVWSAWRRAAPAEESRGRAAVVQKMRACLNNGNAVLNVGESGLTTLPDCLPAHITTLVIPDNNLTSLPAL 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1342388664 241 PPELRTLEVSGNQLTSLPVLPPGLLELSIFSNPLTHLPALPSGLCKLWIFGNQLTSLPVLPPGLQELSVSDNQLASLPAL 320
Cdd:PRK15387  241 PPELRTLEVSGNQLTSLPVLPPGLLELSIFSNPLTHLPALPSGLCKLWIFGNQLTSLPVLPPGLQELSVSDNQLASLPAL 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1342388664 321 PSELCKLWAYNNQLTSLPTLPSGLQELSVSDNQLASLPTLPSELYKLWAYNNRLTSLPALPSGLKELIVSGNRLTSLPVL 400
Cdd:PRK15387  321 PSELCKLWAYNNQLTSLPTLPSGLQELSVSDNQLASLPTLPSELYKLWAYNNRLTSLPALPSGLKELIVSGNRLTSLPVL 400

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1342388664 401 PSELKELMVSGNRLTSLPMLPSGLLSLSVYRNQLTRLPESLIHLSSETTVNLEGNPLSERTLQALREITSAPGYSGPIIQ 480
Cdd:PRK15387  401 PSELKELMVSGNRLTSLPMLPSGLLSLSVYRNQLTRLPESLIHLSSETTVNLEGNPLSERTLQALREITSAPGYSGPIIR 480

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1342388664 481 FDMAGASAPRETRALHLAAADWLVPAREGEPAPADRWHMFGQEDNADAFSLFLDRLSETENFIKDAGFKAQISSWLAQLA 560
Cdd:PRK15387  481 FDMAGASAPRETRALHLAAADWLVPAREGEPAPADRWHMFGQEDNADAFSLFLDRLSETENFIKDAGFKAQISSWLAQLA 560

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1342388664 561 EDEALRANTFAMATEATSSCEDRVTFFLHQMKNVQLVHNAEKGQYDNDLAALVATGREMFRLGKLEQIAREKVRTLALVD 640
Cdd:PRK15387  561 EDEALRANTFAMATEATSSCEDRVTFFLHQMKNVQLVHNAEKGQYDNDLAALVATGREMFRLGKLEQIAREKVRTLALVD 640

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1342388664 641 EIEVWLAYQNKLKKSLGLTSVTAEMRFFDVSGVTVTDLQDAELQVKAAEKSEFREWILQWGPLHRVLERKAPERVNALRE 720
Cdd:PRK15387  641 EIEVWLAYQNKLKKSLGLTSVTSEMRFFDVSGVTVTDLQDAELQVKAAEKSEFREWILQWGPLHRVLERKAPERVNALRE 720

                         730       740       750       760       770       780
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1342388664 721 KQISDYEETYRMLSDTELRPSGLVGNTDAERTIGARAMESAKKTFLDGLRPLVEEMLGSYLNVQWRRN 788
Cdd:PRK15387  721 KQISDYEETYRMLSDTELRPSGLVGNTDAERTIGARAMESAKKTFLDGLRPLVEEMLGSYLNVQWRRN 788
NEL pfam14496
C-terminal novel E3 ligase, LRR-interacting; This NEL or novel E3 ligase domain is found at ...
 502-714 9.20e-85

C-terminal novel E3 ligase, LRR-interacting; This NEL or novel E3 ligase domain is found at the C-terminus of bacterial virulence factors. Its sequence is different from those of the eukaryotic HECT and RING-finger E3 ligases, and it subverts the host ubiquitination process. At the N-terminus of the family-members there is a series of LRR repeats, and the NEL domain interacts with the most N-terminal repeat. The key residue for the ligation step is the cysteine, eg found at position 386 in UniProtKB:E7K2H2. The LRR section sequesters this active site until invasion has occurred.


Pssm-ID: 433992 [Multi-domain]  Cd Length: 216  Bit Score: 268.05  E-value: 9.20e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1342388664 502 WLVPAREGEPAPADRWHMFGQEDNADAFSLFLDRLSETENFIKDA-GFKAQISSWLAQLAEDEALRANTFAMATEATSSC 580
Cdd:pfam14496   1 WLQACAELRPERLAAWRALEAEEGAAAFFRFLARLRETASFRNDAeALRERVWAVLQAAAHDPALRAQLFAIAGDAPASC 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1342388664 581 EDRVTFFLHQMKNVQLVHNAEKGQYDND-LAALVATGREMFRLGKLEQIAREKVRTLALVDEIEVWLAYQNKLKKSLGLT 659
Cdd:pfam14496  81 EDRVTLTFNNLELAVLVHQAEDGAYDGNrLAALLSLGRRLFRLDQLEDIAREKVARRRRVDEIEVRLAYRVRLRESLDLP 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1342388664 660 SVTAEMRFFDVSGVTVTDLQDAELQVKAAE-KSEFREWILQWGPLHRVLERKAPER 714
Cdd:pfam14496 161 NQPPEMRFFNISGVTDADLDRAEARVRAAEtPEAFARWLAQRPFWRQYLERIHPER 216
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
222-501 1.90e-25

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 109.64  E-value: 1.90e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1342388664 222 AHITTLVIPDNNLTSLPAL---PPELRTLEVSGNQLTSLPvlppgllelsifsNPLTHLPALPSglckLWIFGNQLTSLP 298
Cdd:COG4886   113 TNLESLDLSGNQLTDLPEElanLTNLKELDLSNNQLTDLP-------------EPLGNLTNLKS----LDLSNNQLTDLP 175

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1342388664 299 V----LPpGLQELSVSDNQLASLPALPSELC---KLWAYNNQLTSLP----TLPSgLQELSVSDNQLASLPTLP--SELY 365
Cdd:COG4886   176 EelgnLT-NLKELDLSNNQITDLPEPLGNLTnleELDLSGNQLTDLPeplaNLTN-LETLDLSNNQLTDLPELGnlTNLE 253

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1342388664 366 KLWAYNNRLTSLPALP--SGLKELIVSGNRLTSLPVLPSELKELMVSGNRLTSLPMLPSGLLSLSVYRNQLTRLPESLIH 443
Cdd:COG4886   254 ELDLSNNQLTDLPPLAnlTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGL 333

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1342388664 444 LSSETTVNLEGNPLSERTLQALREITSAPGYSGPIIQFDMAGASAPRETRALHLAAAD 501
Cdd:COG4886   334 LVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLL 391
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 284-458 5.20e-09

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 57.10  E-value: 5.20e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1342388664 284 LCKLWIFGNQLTSLPVLP--PGLQELSVSDNQLASLP---ALPSeLCKLWAYNNQLTSLPTL--PSGLQELSVSDNQLAS 356
Cdd:cd21340    26 LKVLYLYDNKITKIENLEflTNLTHLYLQNNQIEKIEnleNLVN-LKKLYLGGNRISVVEGLenLTNLEELHIENQRLPP 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1342388664 357 lptlpselyklwayNNRLT----SLPALPSGLKELIVSGNRLTSLPVLP--SELKELMVSGNRLTSLpmlpsgllslsvy 430
Cdd:cd21340   105 --------------GEKLTfdprSLAALSNSLRVLNISGNNIDSLEPLAplRNLEQLDASNNQISDL------------- 157

                         170       180
                  ....*....|....*....|....*...
gi 1342388664 431 rNQLTRLPESLIHLsseTTVNLEGNPLS 458
Cdd:cd21340   158 -EELLDLLSSWPSL---RELDLTGNPVC 181
 
Name Accession Description Interval E-value
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
1-788 0e+00

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 1607.52  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1342388664   1 MPFHIGSGCLPATISNRRIYRIAWSDTPPEMSSWEKMKEFFCSTHQTEALECIWTICHPPAGTTREDVVSRFELLRTLAY 80
Cdd:PRK15387    1 MPFHIGSGCLPATISNRRIYRIAWSDTPPEMSSWEKMKEFFCSTHQTEALECIWTICHPPAGTTREDVINRFELLRTLAY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1342388664  81 AGWEESIHSGQHGENYFCILDEDSQEILSVTLDDAGNYTVNCQGYSETHRLTLDTAQGEEGTGHAEGASGTFRTSFLPAT 160
Cdd:PRK15387   81 AGWEESIHSGQHGENYFCILDEDSQEILSVTLDDAGNYTVNCQGYSETHRLTLDTAQGEEGTGHAEGASGTFRTSFLPAT 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1342388664 161 TAPQTPAEYDAVWSAWRRAAPAEESRGRAAVVQKMRACLNNGNAVLNVGESGLTTLPDCLPAHITTLVIPDNNLTSLPAL 240
Cdd:PRK15387  161 TAPQTPAEYDAVWSAWRRAAPAEESRGRAAVVQKMRACLNNGNAVLNVGESGLTTLPDCLPAHITTLVIPDNNLTSLPAL 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1342388664 241 PPELRTLEVSGNQLTSLPVLPPGLLELSIFSNPLTHLPALPSGLCKLWIFGNQLTSLPVLPPGLQELSVSDNQLASLPAL 320
Cdd:PRK15387  241 PPELRTLEVSGNQLTSLPVLPPGLLELSIFSNPLTHLPALPSGLCKLWIFGNQLTSLPVLPPGLQELSVSDNQLASLPAL 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1342388664 321 PSELCKLWAYNNQLTSLPTLPSGLQELSVSDNQLASLPTLPSELYKLWAYNNRLTSLPALPSGLKELIVSGNRLTSLPVL 400
Cdd:PRK15387  321 PSELCKLWAYNNQLTSLPTLPSGLQELSVSDNQLASLPTLPSELYKLWAYNNRLTSLPALPSGLKELIVSGNRLTSLPVL 400

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1342388664 401 PSELKELMVSGNRLTSLPMLPSGLLSLSVYRNQLTRLPESLIHLSSETTVNLEGNPLSERTLQALREITSAPGYSGPIIQ 480
Cdd:PRK15387  401 PSELKELMVSGNRLTSLPMLPSGLLSLSVYRNQLTRLPESLIHLSSETTVNLEGNPLSERTLQALREITSAPGYSGPIIR 480

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1342388664 481 FDMAGASAPRETRALHLAAADWLVPAREGEPAPADRWHMFGQEDNADAFSLFLDRLSETENFIKDAGFKAQISSWLAQLA 560
Cdd:PRK15387  481 FDMAGASAPRETRALHLAAADWLVPAREGEPAPADRWHMFGQEDNADAFSLFLDRLSETENFIKDAGFKAQISSWLAQLA 560

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1342388664 561 EDEALRANTFAMATEATSSCEDRVTFFLHQMKNVQLVHNAEKGQYDNDLAALVATGREMFRLGKLEQIAREKVRTLALVD 640
Cdd:PRK15387  561 EDEALRANTFAMATEATSSCEDRVTFFLHQMKNVQLVHNAEKGQYDNDLAALVATGREMFRLGKLEQIAREKVRTLALVD 640

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1342388664 641 EIEVWLAYQNKLKKSLGLTSVTAEMRFFDVSGVTVTDLQDAELQVKAAEKSEFREWILQWGPLHRVLERKAPERVNALRE 720
Cdd:PRK15387  641 EIEVWLAYQNKLKKSLGLTSVTSEMRFFDVSGVTVTDLQDAELQVKAAEKSEFREWILQWGPLHRVLERKAPERVNALRE 720

                         730       740       750       760       770       780
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1342388664 721 KQISDYEETYRMLSDTELRPSGLVGNTDAERTIGARAMESAKKTFLDGLRPLVEEMLGSYLNVQWRRN 788
Cdd:PRK15387  721 KQISDYEETYRMLSDTELRPSGLVGNTDAERTIGARAMESAKKTFLDGLRPLVEEMLGSYLNVQWRRN 788
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
12-785 0e+00

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 651.76  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1342388664  12 ATISNRRIYRIAWSDTPPEMSSWEKMKEFFCSTHQTEALECIWTICHPPAGTTREDVVSRFELLRTLAYAGWEESIHSGQ 91
Cdd:PRK15370    9 STARHQSISNEASTEVPLKEEIWNKISAFFSSEHQVEAQNCIAYLCHPPETASPEEIKSKFECLRMLAFPAYADNIQYSR 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1342388664  92 HGENYFCILDEDSQEILSVTLDDAGnYTVNCQGYSETHrlTLDTAqGEEgtghAEGASGTfrtsflpattapQTPAEYDA 171
Cdd:PRK15370   89 GGADQYCILSENSQEILSIVFNTEG-YTVEGGGKSVTY--TRVTE-SEQ----ASSASGS------------KDAVNYEL 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1342388664 172 VWSAWRRAAPAEESRGRAAVVQKMRACLNNGNAVLNVGESGLTTLPDCLPAHITTLVIPDNNLTSLPA-LPPELRTLEVS 250
Cdd:PRK15370  149 IWSEWVKEAPAKEAANREEAVQRMRDCLKNNKTELRLKILGLTTIPACIPEQITTLILDNNELKSLPEnLQGNIKTLYAN 228

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1342388664 251 GNQLTSLP-VLPPGLLELSIFSNPLTHLPA-LPSGLCKLWIFGNQLTSLP-VLPPGLQELSVSDNQLASLPA-LPSELCK 326
Cdd:PRK15370  229 SNQLTSIPaTLPDTIQEMELSINRITELPErLPSALQSLDLFHNKISCLPeNLPEELRYLSVYDNSIRTLPAhLPSGITH 308

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1342388664 327 LWAYNNQLTSLP-TLPSGLQELSVSDNQLASLPTlpselyklwaynnrltslpALPSGLKELIVSGNRLTSLP-VLPSEL 404
Cdd:PRK15370  309 LNVQSNSLTALPeTLPPGLKTLEAGENALTSLPA-------------------SLPPELQVLDVSKNQITVLPeTLPPTI 369

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1342388664 405 KELMVSGNRLTSLPM-LPSGLLSLSVYRNQLTRLPESLIHLSSE----TTVNLEGNPLSERTLQALREITSAPGYSGPII 479
Cdd:PRK15370  370 TTLDVSRNALTNLPEnLPAALQIMQASRNNLVRLPESLPHFRGEgpqpTRIIVEYNPFSERTIQNMQRLMSSVGYQGPRV 449

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1342388664 480 QFDMAGASAPRETRALHLAAADWLVPAREGEpapADRWHMFGQEDNADAFSLFLDRLSETENfIKDAGFKAQISSWLAQL 559
Cdd:PRK15370  450 LFAMGDFSIVRVTRPLHQAVQGWLTNLEEED---VNQWRAFETEVNAAAFSMFLDRLSDTQN-TRHPDFKEQVSAWLMRL 525

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1342388664 560 AEDEALRANTFAMATEATSSCEDRVTFFLHQMKNVQLVHNAEKGQYDNDLAALVATGREMFRLGKLEQIAREKVRTLALV 639
Cdd:PRK15370  526 AEDSALRETAFIIAMDATISCEDRVTLAYHQMQEATLVHDAERGAFDSHLAELIMAGREIFRLEQIESLAREKVKRLFFI 605

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1342388664 640 DEIEVWLAYQNKLKKSLGLTSVTAEMRFFDVSGVTVTDLQDAELQVKAAEKSEFREWILQWGPLHRVLERKAPERVNALR 719
Cdd:PRK15370  606 DEIEVFLGFQNQLRESLSLTTMTQDMRFYNVSGITESDLDEAEIRIKIAENRDFHKWFALWGPWHKVLERIAPEEWREMM 685

                         730       740       750       760       770       780       790
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1342388664 720 EKQIsDYEET--YRMLSDTELRPSGLVGNTDAERTIGARAMESAKKTFLDGL--RPLVEEMLGSYLNVQW 785
Cdd:PRK15370  686 AKRA-ECIETdeYQSRVNAELEALGIAGDPDAERMAGMRIMEEINQTLFTEImeNILLKKEVSSLMSAYW 754
NEL pfam14496
C-terminal novel E3 ligase, LRR-interacting; This NEL or novel E3 ligase domain is found at ...
 502-714 9.20e-85

C-terminal novel E3 ligase, LRR-interacting; This NEL or novel E3 ligase domain is found at the C-terminus of bacterial virulence factors. Its sequence is different from those of the eukaryotic HECT and RING-finger E3 ligases, and it subverts the host ubiquitination process. At the N-terminus of the family-members there is a series of LRR repeats, and the NEL domain interacts with the most N-terminal repeat. The key residue for the ligation step is the cysteine, eg found at position 386 in UniProtKB:E7K2H2. The LRR section sequesters this active site until invasion has occurred.


Pssm-ID: 433992 [Multi-domain]  Cd Length: 216  Bit Score: 268.05  E-value: 9.20e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1342388664 502 WLVPAREGEPAPADRWHMFGQEDNADAFSLFLDRLSETENFIKDA-GFKAQISSWLAQLAEDEALRANTFAMATEATSSC 580
Cdd:pfam14496   1 WLQACAELRPERLAAWRALEAEEGAAAFFRFLARLRETASFRNDAeALRERVWAVLQAAAHDPALRAQLFAIAGDAPASC 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1342388664 581 EDRVTFFLHQMKNVQLVHNAEKGQYDND-LAALVATGREMFRLGKLEQIAREKVRTLALVDEIEVWLAYQNKLKKSLGLT 659
Cdd:pfam14496  81 EDRVTLTFNNLELAVLVHQAEDGAYDGNrLAALLSLGRRLFRLDQLEDIAREKVARRRRVDEIEVRLAYRVRLRESLDLP 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1342388664 660 SVTAEMRFFDVSGVTVTDLQDAELQVKAAE-KSEFREWILQWGPLHRVLERKAPER 714
Cdd:pfam14496 161 NQPPEMRFFNISGVTDADLDRAEARVRAAEtPEAFARWLAQRPFWRQYLERIHPER 216
PRK15372 PRK15372
type III secretion system effector SseI;
31-142 2.82e-68

type III secretion system effector SseI;


Pssm-ID: 185270  Cd Length: 292  Bit Score: 227.31  E-value: 2.82e-68
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1342388664  31 MSSWEKMKEFFCSTHQTEALECIWTICHPPAGTTREDVVSRFELLRTLAYAGWEESIHSGQHGENYFCILDEDSQEILSV 110
Cdd:PRK15372    1 MSSWEKMKEFFCSTHQTEALECIWTICHPPAGTTREDVVSRFELLRTLAYDGWEENIHSGLHGENYFCILDEDSQEILSV 80

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1342388664 111 TLDDAGNYTVNCQGYSETHRLTLDTAQGEEGT 142
Cdd:PRK15372   81 TLDDVGNYTVNCQGYSETHHLTMATEPGVERT 112
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
222-501 1.90e-25

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 109.64  E-value: 1.90e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1342388664 222 AHITTLVIPDNNLTSLPAL---PPELRTLEVSGNQLTSLPvlppgllelsifsNPLTHLPALPSglckLWIFGNQLTSLP 298
Cdd:COG4886   113 TNLESLDLSGNQLTDLPEElanLTNLKELDLSNNQLTDLP-------------EPLGNLTNLKS----LDLSNNQLTDLP 175

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1342388664 299 V----LPpGLQELSVSDNQLASLPALPSELC---KLWAYNNQLTSLP----TLPSgLQELSVSDNQLASLPTLP--SELY 365
Cdd:COG4886   176 EelgnLT-NLKELDLSNNQITDLPEPLGNLTnleELDLSGNQLTDLPeplaNLTN-LETLDLSNNQLTDLPELGnlTNLE 253

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1342388664 366 KLWAYNNRLTSLPALP--SGLKELIVSGNRLTSLPVLPSELKELMVSGNRLTSLPMLPSGLLSLSVYRNQLTRLPESLIH 443
Cdd:COG4886   254 ELDLSNNQLTDLPPLAnlTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGL 333

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1342388664 444 LSSETTVNLEGNPLSERTLQALREITSAPGYSGPIIQFDMAGASAPRETRALHLAAAD 501
Cdd:COG4886   334 LVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLL 391
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
205-469 3.92e-23

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 102.70  E-value: 3.92e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1342388664 205 VLNVGESGLTTLPDCLPA--HITTLVIPDNNLTSLPA-LP--PELRTLEVSGNQLTSLPV----LPpGLLELSIFSNPLT 275
Cdd:COG4886   117 SLDLSGNQLTDLPEELANltNLKELDLSNNQLTDLPEpLGnlTNLKSLDLSNNQLTDLPEelgnLT-NLKELDLSNNQIT 195

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1342388664 276 HLPALPSGLC---KLWIFGNQLTSLPV-LP--PGLQELSVSDNQLASLPALP--SELCKLWAYNNQLTSLPTLP--SGLQ 345
Cdd:COG4886   196 DLPEPLGNLTnleELDLSGNQLTDLPEpLAnlTNLETLDLSNNQLTDLPELGnlTNLEELDLSNNQLTDLPPLAnlTNLK 275

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1342388664 346 ELSVSDNQLASLPTLPSELYKLWAYNNRLTSLPALPSGLKELIVSGNRLTSLPVLPSELKELMVSGNRLTSLPMLPSGLL 425
Cdd:COG4886   276 TLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLL 355

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....
gi 1342388664 426 SLSVYRNQLTRLPESLIHLSSETTVNLEGNPLSERTLQALREIT 469
Cdd:COG4886   356 LNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAG 399
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
207-459 8.87e-18

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 86.53  E-value: 8.87e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1342388664 207 NVGESGLTTLPDCLPAHITTLVIPDNNLTSLPALPPELRTLEVSGNQLTSLPVLPPGLLELSIFSNPLTHLPALPSGLCK 286
Cdd:COG4886     1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1342388664 287 LWIFGNQLTSLPVLPPGLQELSVSDNQ-LASLPALPSelckLWAYNNQLTSLPT----LPSgLQELSVSDNQLASLPT-- 359
Cdd:COG4886    81 LLSLLLLGLTDLGDLTNLTELDLSGNEeLSNLTNLES----LDLSGNQLTDLPEelanLTN-LKELDLSNNQLTDLPEpl 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1342388664 360 --LPSeLYKLWAYNNRLTSLPA----LPSgLKELIVSGNRLTSLPvlpSELKELmvsgnrltslpmlpSGLLSLSVYRNQ 433
Cdd:COG4886   156 gnLTN-LKSLDLSNNQLTDLPEelgnLTN-LKELDLSNNQITDLP---EPLGNL--------------TNLEELDLSGNQ 216

                         250       260
                  ....*....|....*....|....*.
gi 1342388664 434 LTRLPESLIHLSSETTVNLEGNPLSE 459
Cdd:COG4886   217 LTDLPEPLANLTNLETLDLSNNQLTD 242
PRK15381 PRK15381
type III secretion system effector;
1-113 6.50e-14

type III secretion system effector;


Pssm-ID: 185279  Cd Length: 408  Bit Score: 74.31  E-value: 6.50e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1342388664   1 MPFHIGSGCLPATISNRRIYRIAWSDTPPEMSSWEKMKEFFCSTHQTEALECIWTICH-PPAGTTREDVVSRFELLRTLA 79
Cdd:PRK15381    1 MPLSVGQGYFTSSISSEKFNAIKESARLPELSLWEKIKAYFFTTHHAEALECIFNLYHhQELNLTPVQVRGAYIKLRALA 80

                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 1342388664  80 YAGWEES--IHSGQHGENyFCILDEDSQEILSVTLD 113
Cdd:PRK15381   81 SQGCKEQfiIESQEHADK-LIIKDDNGENILSIEVE 115
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 284-458 5.20e-09

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 57.10  E-value: 5.20e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1342388664 284 LCKLWIFGNQLTSLPVLP--PGLQELSVSDNQLASLP---ALPSeLCKLWAYNNQLTSLPTL--PSGLQELSVSDNQLAS 356
Cdd:cd21340    26 LKVLYLYDNKITKIENLEflTNLTHLYLQNNQIEKIEnleNLVN-LKKLYLGGNRISVVEGLenLTNLEELHIENQRLPP 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1342388664 357 lptlpselyklwayNNRLT----SLPALPSGLKELIVSGNRLTSLPVLP--SELKELMVSGNRLTSLpmlpsgllslsvy 430
Cdd:cd21340   105 --------------GEKLTfdprSLAALSNSLRVLNISGNNIDSLEPLAplRNLEQLDASNNQISDL------------- 157

                         170       180
                  ....*....|....*....|....*...
gi 1342388664 431 rNQLTRLPESLIHLsseTTVNLEGNPLS 458
Cdd:cd21340   158 -EELLDLLSSWPSL---RELDLTGNPVC 181
PRK15386 PRK15386
type III secretion effector GogB;
347-429 1.37e-07

type III secretion effector GogB;


Pssm-ID: 237954 [Multi-domain]  Cd Length: 426  Bit Score: 54.88  E-value: 1.37e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1342388664 347 LSVSDNQLASLPTLPSELYKLWAYN-NRLTSLP-ALPSGLKELIVSgnRLTSLPVLPSELKELMVSGNRLTSLPMLPSGL 424
Cdd:PRK15386   57 LYIKDCDIESLPVLPNELTEITIENcNNLTTLPgSIPEGLEKLTVC--HCPEISGLPESVRSLEIKGSATDSIKNVPNGL 134


                  ....*
gi 1342388664 425 LSLSV 429
Cdd:PRK15386  135 TSLSI 139
PRK15386 PRK15386
type III secretion effector GogB;
227-353 6.00e-07

type III secretion effector GogB;


Pssm-ID: 237954 [Multi-domain]  Cd Length: 426  Bit Score: 52.56  E-value: 6.00e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1342388664 227 LVIPDNNLTSLPALPPELRTLEVSG-NQLTSLP-VLPPGLLELSIFSNPltHLPALPSGLCKLWIFGNQLTSLPVLPPGL 304
Cdd:PRK15386   57 LYIKDCDIESLPVLPNELTEITIENcNNLTTLPgSIPEGLEKLTVCHCP--EISGLPESVRSLEIKGSATDSIKNVPNGL 134

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1342388664 305 QELSVSD----NQLASLPALPSELCKLWAYNNQLTSLPT-LPSGLQELSVSDNQ 353
Cdd:PRK15386  135 TSLSINSynpeNQARIDNLISPSLKTLSLTGCSNIILPEkLPESLQSITLHIEQ 188
PRK15386 PRK15386
type III secretion effector GogB;
287-469 3.10e-05

type III secretion effector GogB;


Pssm-ID: 237954 [Multi-domain]  Cd Length: 426  Bit Score: 47.17  E-value: 3.10e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1342388664 287 LWIFGNQLTSLPVLPPGLQELSVSD-NQLASLP-ALPSELCKLWAynNQLTSLPTLPSGLQELSVSDNQLASLPTLPSEL 364
Cdd:PRK15386   57 LYIKDCDIESLPVLPNELTEITIENcNNLTTLPgSIPEGLEKLTV--CHCPEISGLPESVRSLEIKGSATDSIKNVPNGL 134

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1342388664 365 YKLwaynnrltSLpalpsglkELIVSGNRLTSLPVLPSELKELMVSGNRLTSLPM-LPSGLLSLSVYRNQLTRLPESLIH 443
Cdd:PRK15386  135 TSL--------SI--------NSYNPENQARIDNLISPSLKTLSLTGCSNIILPEkLPESLQSITLHIEQKTTWNISFEG 198

                         170       180
                  ....*....|....*....|....*.
gi 1342388664 444 LSSETTVNLEGNPLSERTLQALREIT 469
Cdd:PRK15386  199 FPDGLDIDLQNSVLLSPDVFKDKNIT 224
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
206-382 3.22e-05

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 47.24  E-value: 3.22e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1342388664 206 LNVGESGLTTLPD--CLPaHITTLVIPDNNLTSLPALP--PELRTLEVSGNQLTSLPVLPPGLLELSIFSNPLTHLPALP 281
Cdd:COG4886   233 LDLSNNQLTDLPElgNLT-NLEELDLSNNQLTDLPPLAnlTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLL 311

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1342388664 282 SGLCKLWIFGNQLTSLPVLPPGLQELSVSDNQLASLPALPSELCKLWAYNNQLTSLPTLPSGLQELSVSDNQLASLPTLP 361
Cdd:COG4886   312 ELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLL 391

                         170       180
                  ....*....|....*....|.
gi 1342388664 362 SELYKLWAYNNRLTSLPALPS 382
Cdd:COG4886   392 LLLTTTAGVLLLTLALLDAVN 412
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 301-472 3.56e-05

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 46.58  E-value: 3.56e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1342388664 301 PPGLQELSVSDNQLASLP-ALPSELCKLwaynnqltslpTLPSGLQELSVSDNQL--ASLPTLPS--------ELYKLwa 369
Cdd:cd00116    50 QPSLKELCLSLNETGRIPrGLQSLLQGL-----------TKGCGLQELDLSDNALgpDGCGVLESllrssslqELKLN-- 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1342388664 370 yNNRL---------TSLPALPSGLKELIVSGNRLTS---------LPVLPSeLKELMVSGNRLT---------SLPMLpS 422
Cdd:cd00116   117 -NNGLgdrglrllaKGLKDLPPALEKLVLGRNRLEGascealakaLRANRD-LKELNLANNGIGdagiralaeGLKAN-C 193

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1342388664 423 GLLSLSVYRNQLTR-----LPESLIHLSSETTVNLEGNPLSERTLQALREITSAP 472
Cdd:cd00116   194 NLEVLDLNNNGLTDegasaLAETLASLKSLEVLNLGDNNLTDAGAAALASALLSP 248
LRR_8 pfam13855
Leucine rich repeat;
402-457 4.80e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 41.74  E-value: 4.80e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1342388664 402 SELKELMVSGNRLTSLPM-----LPSgLLSLSVYRNQLTRL-PESLIHLSSETTVNLEGNPL 457
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDgafkgLSN-LKVLDLSNNLLTTLsPGAFSGLPSLRYLDLSGNRL 61
PRK15386 PRK15386
type III secretion effector GogB;
213-313 4.90e-05

type III secretion effector GogB;


Pssm-ID: 237954 [Multi-domain]  Cd Length: 426  Bit Score: 46.40  E-value: 4.90e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1342388664 213 LTTLPDCLPAHITTLVIpdNNLTSLPALPPELRTLEVSGNQLTSLPVLPPGLLELSIFS-NPLTHL---PALPSGLCKLW 288
Cdd:PRK15386   85 LTTLPGSIPEGLEKLTV--CHCPEISGLPESVRSLEIKGSATDSIKNVPNGLTSLSINSyNPENQAridNLISPSLKTLS 162

                          90       100
                  ....*....|....*....|....*.
gi 1342388664 289 IFGNQLTSLPV-LPPGLQELSVSDNQ 313
Cdd:PRK15386  163 LTGCSNIILPEkLPESLQSITLHIEQ 188
sifA PRK09498
type III secretion system effector SifA;
1-111 4.70e-04

type III secretion system effector SifA;


Pssm-ID: 181911  Cd Length: 336  Bit Score: 43.08  E-value: 4.70e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1342388664   1 MPFHIGSGCLPATI--SNRRIYRIAWSDTppemsSWEKMKEFFCSTHQTEALECIWTICHPPAGTTREDVVSRFELLRTL 78
Cdd:PRK09498    1 MPITIGNGFLKSEIltNSPRNTKEAWWKV-----LWEKIKDFFFSTGKAKADRCLHEMLFADRAPTRERLTEIFFELKEL 75

                          90       100       110
                  ....*....|....*....|....*....|....*...
gi 1342388664  79 AYAGWEESIHSGQHGEN----YFCILDEDSQ-EILSVT 111
Cdd:PRK09498   76 ACASQRDRFQVHNPHENdatiILRIMDQNEEnELLRIT 113
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 277-395 5.61e-04

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 42.73  E-value: 5.61e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1342388664 277 LPALPSGLCKLWIFGNQLTSLP------VLP--PGLQELSVSDNQL------ASLPALP--SELCKLWAYNNQLTS---- 336
Cdd:cd00116   132 LKDLPPALEKLVLGRNRLEGAScealakALRanRDLKELNLANNGIgdagirALAEGLKanCNLEVLDLNNNGLTDegas 211

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1342388664 337 -----LPTLPSgLQELSVSDNQLAS---------LPTLPSELYKLWAYNNRLT---------SLPALPSgLKELIVSGNR 393
Cdd:cd00116   212 alaetLASLKS-LEVLNLGDNNLTDagaaalasaLLSPNISLLTLSLSCNDITddgakdlaeVLAEKES-LLELDLRGNK 289


                  ..
gi 1342388664 394 LT 395
Cdd:cd00116   290 FG 291
PLN03210 PLN03210
Resistant to P. syringae 6; Provisional
 260-456 1.35e-03

Resistant to P. syringae 6; Provisional


Pssm-ID: 215633 [Multi-domain]  Cd Length: 1153  Bit Score: 42.55  E-value: 1.35e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1342388664  260 LPPGLLELSIFSNPLTHLPA--LPSGLCKLWIFGNQLTSL--PVLP-PGLQELSV--SDNqLASLP--ALPSELCKLwaY 330
Cdd:PLN03210   587 LPPKLRLLRWDKYPLRCMPSnfRPENLVKLQMQGSKLEKLwdGVHSlTGLRNIDLrgSKN-LKEIPdlSMATNLETL--K 663

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1342388664  331 NNQLTSLPTLPSGLQELsvsdNQLAS--------LPTLPS--ELYKLWAYN----NRLTSLPALPSGLKELIVSGnrlTS 396
Cdd:PLN03210   664 LSDCSSLVELPSSIQYL----NKLEDldmsrcenLEILPTgiNLKSLYRLNlsgcSRLKSFPDISTNISWLDLDE---TA 736

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1342388664  397 LPVLPSELK-----EL----MVSGNR------LTSL-PMLPSGLLSLSVYRNQ-LTRLPES------LIHLSSETTVNLE 453
Cdd:PLN03210   737 IEEFPSNLRlenldELilceMKSEKLwervqpLTPLmTMLSPSLTRLFLSDIPsLVELPSSiqnlhkLEHLEIENCINLE 816


                   ...
gi 1342388664  454 GNP 456
Cdd:PLN03210   817 TLP 819
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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