NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1352183597|gb|AVI54613|]
View 

3-isopropylmalate dehydrogenase [Escherichia coli str. K-12 substr. MG1655]

Protein Classification

3-isopropylmalate dehydrogenase( domain architecture ID 10011514)

3-isopropylmalate dehydrogenase catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate

CATH:  3.40.718.10
EC:  1.1.1.85
Gene Symbol:  leuB
Gene Ontology:  GO:0003862|GO:0046872|GO:0051287
SCOP:  4000791

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
PRK00772 PRK00772
3-isopropylmalate dehydrogenase; Provisional
 3-362 0e+00

3-isopropylmalate dehydrogenase; Provisional


:

Pssm-ID: 234832  Cd Length: 358  Bit Score: 698.39  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352183597   3 KNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEGCEQADAVLFGSVGGPKWE 82
Cdd:PRK00772    1 MTYKIAVLPGDGIGPEVMAEAVKVLDAVAEKFGFDFEFEEALVGGAAIDAHGVPLPEETLEACRAADAVLLGAVGGPKWD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352183597  83 HLPPDQQPERGaLLPLRKHFKLFSNLRPAKLYQGLEAFCPLRADIAAnGFDILCVRELTGGIYFGQPKGREGSGQYEKAF 162
Cdd:PRK00772   81 NLPPDVRPERG-LLALRKELGLFANLRPAKLYPGLADASPLKPEIVA-GLDILIVRELTGGIYFGEPRGREGLGGEERAF 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352183597 163 DTEVYHRFEIERIARIAFESARKRRHKVTSIDKANVLQSSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFDV 242
Cdd:PRK00772  159 DTMVYTREEIERIARVAFELARKRRKKVTSVDKANVLESSRLWREVVTEVAKEYPDVELSHMYVDNAAMQLVRNPKQFDV 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352183597 243 LLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQILSLALLLRYSLDADDAACAI 322
Cdd:PRK00772  239 IVTENLFGDILSDEAAMLTGSLGMLPSASLGESGPGLYEPIHGSAPDIAGKGIANPIATILSAAMMLRYSLGLEEAADAI 318

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|
gi 1352183597 323 ERAINRALEEGIRTGDLARGAAAVSTDEMGDIIARYVAEG 362
Cdd:PRK00772  319 EAAVEKVLAQGYRTADIAEGGGKVSTSEMGDAILAALAEG 358
 
Name Accession Description Interval E-value
PRK00772 PRK00772
3-isopropylmalate dehydrogenase; Provisional
 3-362 0e+00

3-isopropylmalate dehydrogenase; Provisional


Pssm-ID: 234832  Cd Length: 358  Bit Score: 698.39  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352183597   3 KNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEGCEQADAVLFGSVGGPKWE 82
Cdd:PRK00772    1 MTYKIAVLPGDGIGPEVMAEAVKVLDAVAEKFGFDFEFEEALVGGAAIDAHGVPLPEETLEACRAADAVLLGAVGGPKWD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352183597  83 HLPPDQQPERGaLLPLRKHFKLFSNLRPAKLYQGLEAFCPLRADIAAnGFDILCVRELTGGIYFGQPKGREGSGQYEKAF 162
Cdd:PRK00772   81 NLPPDVRPERG-LLALRKELGLFANLRPAKLYPGLADASPLKPEIVA-GLDILIVRELTGGIYFGEPRGREGLGGEERAF 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352183597 163 DTEVYHRFEIERIARIAFESARKRRHKVTSIDKANVLQSSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFDV 242
Cdd:PRK00772  159 DTMVYTREEIERIARVAFELARKRRKKVTSVDKANVLESSRLWREVVTEVAKEYPDVELSHMYVDNAAMQLVRNPKQFDV 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352183597 243 LLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQILSLALLLRYSLDADDAACAI 322
Cdd:PRK00772  239 IVTENLFGDILSDEAAMLTGSLGMLPSASLGESGPGLYEPIHGSAPDIAGKGIANPIATILSAAMMLRYSLGLEEAADAI 318

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|
gi 1352183597 323 ERAINRALEEGIRTGDLARGAAAVSTDEMGDIIARYVAEG 362
Cdd:PRK00772  319 EAAVEKVLAQGYRTADIAEGGGKVSTSEMGDAILAALAEG 358
leuB TIGR00169
3-isopropylmalate dehydrogenase; Several NAD- or NADP-dependent dehydrogenases, including ...
 6-355 0e+00

3-isopropylmalate dehydrogenase; Several NAD- or NADP-dependent dehydrogenases, including 3-isopropylmalate dehydrogenase, tartrate dehydrogenase, and the dimeric forms of isocitrate dehydrogenase, share a nucleotide binding domain unrelated to that of lactate dehydrogenase and its homologs. These enzymes dehydrogenate their substates at a H-C-OH site adjacent to a H-C-COOH site; the latter carbon, now adjacent to a carbonyl group, readily decarboxylates.Among these decarboxylating dehydrogenases of hydroxyacids, overall sequence homology indicates evolutionary history rather than actual substrate or cofactor specifity, which may be toggled experimentally by replacement of just a few amino acids. 3-isopropylmalate dehydrogenase is an NAD-dependent enzyme and should have a sequence resembling HGSAPDI around residue 340. The subtrate binding loop should include a sequence resembling E[KQR]X(0,1)LLXXR around residue 115. Other contacts of importance are known from crystallography but not detailed here.This model will not find all isopropylmalate dehydrogenases; the enzyme from Sulfolobus sp. strain 7 is more similar to mitochondrial NAD-dependent isocitrate dehydrogenases than to other known isopropylmalate dehydrogenases and was omitted to improve the specificity of the model. It scores below the cutoff and below some enzymes known not to be isopropylmalate dehydrogenase. [Amino acid biosynthesis, Pyruvate family]


Pssm-ID: 272939  Cd Length: 346  Bit Score: 632.51  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352183597   6 HIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEGCEQADAVLFGSVGGPKWEHLP 85
Cdd:TIGR00169   1 KIAVLPGDGIGPEVMAQALKVLKAVAERFGLKFEFEEHLIGGAAIDATGQPLPEETLKGCKEADAVLLGAVGGPKWDNLP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352183597  86 PDQQPERGaLLPLRKHFKLFSNLRPAKLYQGLEAFCPLRADIAaNGFDILCVRELTGGIYFGQPKGREGSGqyeKAFDTE 165
Cdd:TIGR00169  81 RDQRPEQG-LLKLRKSLDLFANLRPAKVFPGLEDLSPLKEEIA-KGVDFVVVRELTGGIYFGEPKGREGEG---EAWDTE 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352183597 166 VYHRFEIERIARIAFESARKRRHKVTSIDKANVLQSSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFDVLLC 245
Cdd:TIGR00169 156 VYTVPEIERIARVAFEMARKRRKKVTSVDKANVLESSRLWRKTVEEIAKEYPDVELEHQYIDNAAMQLVKSPTQFDVVVT 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352183597 246 SNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQILSLALLLRYSLDADDAACAIERA 325
Cdd:TIGR00169 236 SNLFGDILSDEASVITGSLGMLPSASLGSDGFGLFEPVHGSAPDIAGKGIANPIAQILSAAMLLRYSFNLEEAADAIEAA 315

                         330       340       350
                  ....*....|....*....|....*....|.
gi 1352183597 326 INRALEEGIRTGDLARGA-AAVSTDEMGDII 355
Cdd:TIGR00169 316 VKKVLAEGYRTPDLGSSAtTAVGTAEMGEEL 346
LeuB COG0473
Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid ...
 4-359 0e+00

Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid transport and metabolism]; Isocitrate/isopropylmalate dehydrogenase is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 440241  Cd Length: 346  Bit Score: 575.42  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352183597   4 NYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEGCEQADAVLFGSVGGPKWeh 83
Cdd:COG0473     1 TYKIAVLPGDGIGPEVVAAALKVLEAAAERFGLDFEFEEADIGGAAYDKTGTPLPDETLEALRKADAILLGAVGGPKW-- 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352183597  84 lPPDQQPERGaLLPLRKHFKLFSNLRPAKLYQGLEafCPLRADIAAnGFDILCVRELTGGIYFGQPKGREGSGQYEKAFD 163
Cdd:COG0473    79 -DDGVRPESG-LLALRKELDLYANLRPAKLYPGLP--SPLKPEIVE-GIDLVIVRENTEGLYFGIGGRIGTGTGEEVAID 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352183597 164 TEVYHRFEIERIARIAFESARKRRHKVTSIDKANVL-QSSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFDV 242
Cdd:COG0473   154 TRVYTRKGIERIARYAFELARKRRKKVTSVDKANVLkLTSGLWREVVREVAKEYPDVELDHMYVDAAAMQLVRNPEQFDV 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352183597 243 LLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQILSLALLLRYsLDADDAACAI 322
Cdd:COG0473   234 IVTENLFGDILSDLAAGLTGSLGLAPSANIGDEGKALFEPVHGSAPDIAGKGIANPIATILSAAMMLRH-LGEEEAADAI 312

                         330       340       350
                  ....*....|....*....|....*....|....*..
gi 1352183597 323 ERAINRALEEGIRTGDLargAAAVSTDEMGDIIARYV 359
Cdd:COG0473   313 EAAVEKVLAEGVRTPDL---GGKAGTSEMGDAIIAAL 346
Iso_dh pfam00180
Isocitrate/isopropylmalate dehydrogenase;
6-355 0e+00

Isocitrate/isopropylmalate dehydrogenase;


Pssm-ID: 425507  Cd Length: 346  Bit Score: 550.36  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352183597   6 HIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEGCEQADAVLFGSVGGPKWEhlP 85
Cdd:pfam00180   1 KIAVLPGDGIGPEVMAAALKVLKAALEKAPLEFEFEERDVGGAAIDETGEPLPDETLEACKKADAVLLGAVGGPKWD--P 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352183597  86 PDQQPERGaLLPLRKHFKLFSNLRPAKLYQGLEAFCPLRADIAanGFDILCVRELTGGIYFGQPKGREGSGQyEKAFDTE 165
Cdd:pfam00180  79 AGVRPENG-LLALRKELGLFANLRPAKVFPPLGDASPLKNEVE--GVDIVIVRELTGGIYFGIEKGIKGSGN-EVAVDTK 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352183597 166 VYHRFEIERIARIAFESARKR-RHKVTSIDKANVLQSSILWREIVNEIAT-EYPDVELAHMYIDNATMQLIKDPSQFDVL 243
Cdd:pfam00180 155 LYSRDEIERIARVAFELARKRgRKKVTSVDKANVLKSSDLWRKIVTEVAKaEYPDVELEHQLVDNAAMQLVKNPSQFDVI 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352183597 244 LCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQILSLALLLRYSLDADDAACAIE 323
Cdd:pfam00180 235 VTPNLFGDILSDEASMLTGSLGLLPSASLGANGFGIFEPVHGSAPDIAGKGIANPIATILSAAMMLRYSLGLEDAADKIE 314

                         330       340       350
                  ....*....|....*....|....*....|..
gi 1352183597 324 RAINRALEEGIRTGDLARGAAAVSTDEMGDII 355
Cdd:pfam00180 315 AAVLKVLESGIRTGDLAGSATYVSTSEFGEAV 346
 
Name Accession Description Interval E-value
PRK00772 PRK00772
3-isopropylmalate dehydrogenase; Provisional
 3-362 0e+00

3-isopropylmalate dehydrogenase; Provisional


Pssm-ID: 234832  Cd Length: 358  Bit Score: 698.39  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352183597   3 KNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEGCEQADAVLFGSVGGPKWE 82
Cdd:PRK00772    1 MTYKIAVLPGDGIGPEVMAEAVKVLDAVAEKFGFDFEFEEALVGGAAIDAHGVPLPEETLEACRAADAVLLGAVGGPKWD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352183597  83 HLPPDQQPERGaLLPLRKHFKLFSNLRPAKLYQGLEAFCPLRADIAAnGFDILCVRELTGGIYFGQPKGREGSGQYEKAF 162
Cdd:PRK00772   81 NLPPDVRPERG-LLALRKELGLFANLRPAKLYPGLADASPLKPEIVA-GLDILIVRELTGGIYFGEPRGREGLGGEERAF 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352183597 163 DTEVYHRFEIERIARIAFESARKRRHKVTSIDKANVLQSSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFDV 242
Cdd:PRK00772  159 DTMVYTREEIERIARVAFELARKRRKKVTSVDKANVLESSRLWREVVTEVAKEYPDVELSHMYVDNAAMQLVRNPKQFDV 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352183597 243 LLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQILSLALLLRYSLDADDAACAI 322
Cdd:PRK00772  239 IVTENLFGDILSDEAAMLTGSLGMLPSASLGESGPGLYEPIHGSAPDIAGKGIANPIATILSAAMMLRYSLGLEEAADAI 318

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|
gi 1352183597 323 ERAINRALEEGIRTGDLARGAAAVSTDEMGDIIARYVAEG 362
Cdd:PRK00772  319 EAAVEKVLAQGYRTADIAEGGGKVSTSEMGDAILAALAEG 358
leuB TIGR00169
3-isopropylmalate dehydrogenase; Several NAD- or NADP-dependent dehydrogenases, including ...
 6-355 0e+00

3-isopropylmalate dehydrogenase; Several NAD- or NADP-dependent dehydrogenases, including 3-isopropylmalate dehydrogenase, tartrate dehydrogenase, and the dimeric forms of isocitrate dehydrogenase, share a nucleotide binding domain unrelated to that of lactate dehydrogenase and its homologs. These enzymes dehydrogenate their substates at a H-C-OH site adjacent to a H-C-COOH site; the latter carbon, now adjacent to a carbonyl group, readily decarboxylates.Among these decarboxylating dehydrogenases of hydroxyacids, overall sequence homology indicates evolutionary history rather than actual substrate or cofactor specifity, which may be toggled experimentally by replacement of just a few amino acids. 3-isopropylmalate dehydrogenase is an NAD-dependent enzyme and should have a sequence resembling HGSAPDI around residue 340. The subtrate binding loop should include a sequence resembling E[KQR]X(0,1)LLXXR around residue 115. Other contacts of importance are known from crystallography but not detailed here.This model will not find all isopropylmalate dehydrogenases; the enzyme from Sulfolobus sp. strain 7 is more similar to mitochondrial NAD-dependent isocitrate dehydrogenases than to other known isopropylmalate dehydrogenases and was omitted to improve the specificity of the model. It scores below the cutoff and below some enzymes known not to be isopropylmalate dehydrogenase. [Amino acid biosynthesis, Pyruvate family]


Pssm-ID: 272939  Cd Length: 346  Bit Score: 632.51  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352183597   6 HIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEGCEQADAVLFGSVGGPKWEHLP 85
Cdd:TIGR00169   1 KIAVLPGDGIGPEVMAQALKVLKAVAERFGLKFEFEEHLIGGAAIDATGQPLPEETLKGCKEADAVLLGAVGGPKWDNLP 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352183597  86 PDQQPERGaLLPLRKHFKLFSNLRPAKLYQGLEAFCPLRADIAaNGFDILCVRELTGGIYFGQPKGREGSGqyeKAFDTE 165
Cdd:TIGR00169  81 RDQRPEQG-LLKLRKSLDLFANLRPAKVFPGLEDLSPLKEEIA-KGVDFVVVRELTGGIYFGEPKGREGEG---EAWDTE 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352183597 166 VYHRFEIERIARIAFESARKRRHKVTSIDKANVLQSSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFDVLLC 245
Cdd:TIGR00169 156 VYTVPEIERIARVAFEMARKRRKKVTSVDKANVLESSRLWRKTVEEIAKEYPDVELEHQYIDNAAMQLVKSPTQFDVVVT 235

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352183597 246 SNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQILSLALLLRYSLDADDAACAIERA 325
Cdd:TIGR00169 236 SNLFGDILSDEASVITGSLGMLPSASLGSDGFGLFEPVHGSAPDIAGKGIANPIAQILSAAMLLRYSFNLEEAADAIEAA 315

                         330       340       350
                  ....*....|....*....|....*....|.
gi 1352183597 326 INRALEEGIRTGDLARGA-AAVSTDEMGDII 355
Cdd:TIGR00169 316 VKKVLAEGYRTPDLGSSAtTAVGTAEMGEEL 346
LeuB COG0473
Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid ...
 4-359 0e+00

Isocitrate/isopropylmalate dehydrogenase [Energy production and conversion, Amino acid transport and metabolism]; Isocitrate/isopropylmalate dehydrogenase is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 440241  Cd Length: 346  Bit Score: 575.42  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352183597   4 NYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEGCEQADAVLFGSVGGPKWeh 83
Cdd:COG0473     1 TYKIAVLPGDGIGPEVVAAALKVLEAAAERFGLDFEFEEADIGGAAYDKTGTPLPDETLEALRKADAILLGAVGGPKW-- 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352183597  84 lPPDQQPERGaLLPLRKHFKLFSNLRPAKLYQGLEafCPLRADIAAnGFDILCVRELTGGIYFGQPKGREGSGQYEKAFD 163
Cdd:COG0473    79 -DDGVRPESG-LLALRKELDLYANLRPAKLYPGLP--SPLKPEIVE-GIDLVIVRENTEGLYFGIGGRIGTGTGEEVAID 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352183597 164 TEVYHRFEIERIARIAFESARKRRHKVTSIDKANVL-QSSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFDV 242
Cdd:COG0473   154 TRVYTRKGIERIARYAFELARKRRKKVTSVDKANVLkLTSGLWREVVREVAKEYPDVELDHMYVDAAAMQLVRNPEQFDV 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352183597 243 LLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQILSLALLLRYsLDADDAACAI 322
Cdd:COG0473   234 IVTENLFGDILSDLAAGLTGSLGLAPSANIGDEGKALFEPVHGSAPDIAGKGIANPIATILSAAMMLRH-LGEEEAADAI 312

                         330       340       350
                  ....*....|....*....|....*....|....*..
gi 1352183597 323 ERAINRALEEGIRTGDLargAAAVSTDEMGDIIARYV 359
Cdd:COG0473   313 EAAVEKVLAEGVRTPDL---GGKAGTSEMGDAIIAAL 346
Iso_dh pfam00180
Isocitrate/isopropylmalate dehydrogenase;
6-355 0e+00

Isocitrate/isopropylmalate dehydrogenase;


Pssm-ID: 425507  Cd Length: 346  Bit Score: 550.36  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352183597   6 HIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEGCEQADAVLFGSVGGPKWEhlP 85
Cdd:pfam00180   1 KIAVLPGDGIGPEVMAAALKVLKAALEKAPLEFEFEERDVGGAAIDETGEPLPDETLEACKKADAVLLGAVGGPKWD--P 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352183597  86 PDQQPERGaLLPLRKHFKLFSNLRPAKLYQGLEAFCPLRADIAanGFDILCVRELTGGIYFGQPKGREGSGQyEKAFDTE 165
Cdd:pfam00180  79 AGVRPENG-LLALRKELGLFANLRPAKVFPPLGDASPLKNEVE--GVDIVIVRELTGGIYFGIEKGIKGSGN-EVAVDTK 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352183597 166 VYHRFEIERIARIAFESARKR-RHKVTSIDKANVLQSSILWREIVNEIAT-EYPDVELAHMYIDNATMQLIKDPSQFDVL 243
Cdd:pfam00180 155 LYSRDEIERIARVAFELARKRgRKKVTSVDKANVLKSSDLWRKIVTEVAKaEYPDVELEHQLVDNAAMQLVKNPSQFDVI 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352183597 244 LCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQILSLALLLRYSLDADDAACAIE 323
Cdd:pfam00180 235 VTPNLFGDILSDEASMLTGSLGLLPSASLGANGFGIFEPVHGSAPDIAGKGIANPIATILSAAMMLRYSLGLEDAADKIE 314

                         330       340       350
                  ....*....|....*....|....*....|..
gi 1352183597 324 RAINRALEEGIRTGDLARGAAAVSTDEMGDII 355
Cdd:pfam00180 315 AAVLKVLESGIRTGDLAGSATYVSTSEFGEAV 346
PLN02329 PLN02329
3-isopropylmalate dehydrogenase
 3-363 2.45e-119

3-isopropylmalate dehydrogenase


Pssm-ID: 215188  Cd Length: 409  Bit Score: 351.30  E-value: 2.45e-119
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352183597   3 KNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEGCEQADAVLFGSVGGPKWE 82
Cdd:PLN02329   45 KRYNIALLPGDGIGPEVISVAKNVLQKAGSLEGLEFDFQEMPVGGAALDLVGVPLPEETFTAAKQSDAILLGAIGGYKWD 124

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352183597  83 HLPPDQQPERGaLLPLRKHFKLFSNLRPAKLYQGLEAFCPLRADIAaNGFDILCVRELTGGIYFGQPKG-REGSGQYEKA 161
Cdd:PLN02329  125 KNEKHLRPEMA-LFYLRRDLKVFANLRPATVLPQLVDASTLKKEVA-EGVDMMIVRELTGGIYFGEPRGiTINENGEEVG 202

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352183597 162 FDTEVYHRFEIERIARIAFESARKRRHKVTSIDKANVLQSSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFD 241
Cdd:PLN02329  203 VSTEIYAAHEIDRIARVAFETARKRRGKLCSVDKANVLDASILWRKRVTALASEYPDVELSHMYVDNAAMQLIRDPKQFD 282

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352183597 242 VLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQILSLALLLRYSLDADDAACA 321
Cdd:PLN02329  283 TIVTNNIFGDILSDEASMITGSIGMLPSASLGESGPGLFEPIHGSAPDIAGQDKANPLATILSAAMLLKYGLGEEKAAKR 362

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|...
gi 1352183597 322 IERAINRALEEGIRTGDL-ARGAAAVSTDEMGDIIARYVAEGV 363
Cdd:PLN02329  363 IEDAVVDALNKGFRTGDIySPGNKLVGCKEMGEEVLKSVDSKV 405
PRK03437 PRK03437
3-isopropylmalate dehydrogenase; Provisional
 1-359 5.93e-105

3-isopropylmalate dehydrogenase; Provisional


Pssm-ID: 179579  Cd Length: 344  Bit Score: 312.25  E-value: 5.93e-105
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352183597   1 MSKNYHIAVLPGDGIGPEVMTQALKVLDAVRNRfAMRITTSHYDVGGAAIDNHGQPLPPATVEGCEQADAVLFGSVGGPK 80
Cdd:PRK03437    1 MAKTMKLAVIPGDGIGPEVVAEALKVLDAVAAG-GPGVETTEYDLGARRYLRTGETLPDSVLAELRQHDAILLGAIGDPS 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352183597  81 wehLPPDQQpERGALLPLRKHFKLFSNLRPAKLYQGLEafCPLradiAANG-FDILCVRELTGGIYFGQpkG---REGSG 156
Cdd:PRK03437   80 ---VPSGVL-ERGLLLKLRFALDHYVNLRPSKLYPGVT--SPL----AGPGdIDFVVVREGTEGPYTGN--GgalRVGTP 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352183597 157 QyEKAFDTEVYHRFEIERIARIAFESARKR-RHKVTSIDKANVL-QSSILWREIVNEIATEYPDVELAHMYIDNATMQLI 234
Cdd:PRK03437  148 H-EVATEVSVNTAFGVERVVRDAFERAQKRpRKHLTLVHKTNVLtFAGDLWQRTVDEVAAEYPDVTVDYQHVDAATIFMV 226

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352183597 235 KDPSQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFG--LYEPAGGSAPDIAGKNIANPIAQILSLALLLRYs 312
Cdd:PRK03437  227 TDPSRFDVIVTDNLFGDIITDLAAAVTGGIGLAASGNINPTGTNpsMFEPVHGSAPDIAGQGIADPTAAILSVALLLDH- 305

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*..
gi 1352183597 313 LDADDAACAIERAINRALEEgirtgdlaRGAAAVSTDEMGDIIARYV 359
Cdd:PRK03437  306 LGEEDAAARIEAAVEADLAE--------RGKMGRSTAEVGDRIAARL 344
TTC TIGR02089
tartrate dehydrogenase; Tartrate dehydrogenase catalyzes the oxidation of both meso- and (+) ...
 3-356 3.06e-92

tartrate dehydrogenase; Tartrate dehydrogenase catalyzes the oxidation of both meso- and (+)-tartrate as well as a D-malate. These enzymes are closely related to the 3-isopropylmalate and isohomocitrate dehydrogenases found in TIGR00169 and TIGR02088, respectively. [Energy metabolism, Other]


Pssm-ID: 273963  Cd Length: 352  Bit Score: 279.80  E-value: 3.06e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352183597   3 KNYHIAVLPGDGIGPEVMTQALKVLDAVRNRFA-MRITTSHYDVGGAAIDNHGQPLPPATVEGCEQADAVLFGSVGGPKw 81
Cdd:TIGR02089   2 KQYRIAAIPGDGIGKEVVAAALQVLEAAAKRHGgFSLHFTEFPWSCDYYKEHGKMMPEDGLEKLKKFDAIFLGAVGWPA- 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352183597  82 ehLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAfcPLRADiAANGFDILCVRELTGGIYFGQpKGREGSG-QYEK 160
Cdd:TIGR02089  81 --LVPDHISLWGLLLKIRREFDQYANVRPAKLLPGVTS--PLRNC-GPGDFDFVVVRENSEGEYSGV-GGRIHRGtDEEV 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352183597 161 AFDTEVYHRFEIERIARIAFESARKRRHKVTSIDKANVLQSSI-LWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQ 239
Cdd:TIGR02089 155 ATQNAIFTRKGVERIMRFAFELAQKRRKHLTSATKSNGIRHSMpFWDEVFAEVAAEYPDVEWDSYHIDALAARFVLKPET 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352183597 240 FDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGF--GLYEPAGGSAPDIAGKNIANPIAQILSLALLLRYsLDADD 317
Cdd:TIGR02089 235 FDVIVASNLFGDILSDLGAALMGSLGVAPSANINPEGKfpSMFEPVHGSAPDIAGKGIANPIGAIWTAAMMLEH-LGEKE 313

                         330       340       350
                  ....*....|....*....|....*....|....*....
gi 1352183597 318 AACAIERAINRALEEGIRTGDLARGAaavSTDEMGDIIA 356
Cdd:TIGR02089 314 AGAKIMDAIERVTAAGILTPDVGGKA---TTSEVTEAVC 349
PRK14025 PRK14025
multifunctional 3-isopropylmalate dehydrogenase/D-malate dehydrogenase; Provisional
 5-359 8.00e-85

multifunctional 3-isopropylmalate dehydrogenase/D-malate dehydrogenase; Provisional


Pssm-ID: 184462  Cd Length: 330  Bit Score: 260.07  E-value: 8.00e-85
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352183597   5 YHIAVLPGDGIGPEVMTQALKVLDAVRNRFAMrittSHYDVGGAAIDNHGQPLPPATVEGCEQADAVLFGSVGgpkweHL 84
Cdd:PRK14025    2 HKICVIEGDGIGKEVVPAALHVLEATGLPFEF----VYAEAGDEVFEKTGKALPEETIEAAKEADAVLFGAAG-----ET 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352183597  85 PPDqqpergALLPLRKHFKLFSNLRPAKLYQGLEAFCPlradiaanGFDILCVRELTGGIYfgqpKGREGSGQYEKAFDT 164
Cdd:PRK14025   73 AAD------VIVKLRRILDTYANVRPVKSYKGVKCLYP--------DIDYVIVRENTEGLY----KGIEAEIADGVTVAT 134

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352183597 165 EVYHRFEIERIARIAFESARKR-----RHKVTSIDKANVLQSSI-LWREIVNEIATEYPDVELAHMYIDNATMQLIKDPS 238
Cdd:PRK14025  135 RVITRKASERIFRFAFEMAKRRkkmgkEGKVTCAHKANVLKKTDgLFKKTFYEVAKEYPDIKAEDYYVDAMNMYIITRPQ 214

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352183597 239 QFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQgFGLYEPAGGSAPDIAGKNIANPIAQILSLALLLRYsLDADDA 318
Cdd:PRK14025  215 TFDVVVTSNLFGDILSDGAAGLVGGLGLAPSANIGDK-YGLFEPVHGSAPDIAGKGIANPTATILTAVLMLRH-LGENEE 292

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|.
gi 1352183597 319 ACAIERAINRALEEGIRTGDLargAAAVSTDEMGDIIARYV 359
Cdd:PRK14025  293 ADKVEKALEEVLALGLTTPDL---GGNLSTMEMAEEVAKRV 330
PRK08194 PRK08194
tartrate dehydrogenase; Provisional
 3-357 1.41e-83

tartrate dehydrogenase; Provisional


Pssm-ID: 181281  Cd Length: 352  Bit Score: 257.73  E-value: 1.41e-83
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352183597   3 KNYHIAVLPGDGIGPEVMTQALKVLDAV-RNRFAMRITTSHYDVGGAAIDNHGQPLPPATVEGCEQADAVLFGSVGGPKw 81
Cdd:PRK08194    2 KQFKIAVIPGDGVGKEVVPAAVRVLKAVaEVHGGLKFEFTEFPWSCEYYLEHGEMMPEDGLEQLKQFDAIFLGAVGNPK- 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352183597  82 ehLPPDQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAfcPLRAdiaANGFDILCVRELTGGIYfGQPKGREGSGQYEKA 161
Cdd:PRK08194   81 --LVPDHISLWGLLIKIRREFEQVINIRPAKQLRGIKS--PLAN---PKDFDLLVVRENSEGEY-SEVGGRIHRGEDEIA 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352183597 162 FDTEVYHRFEIERIARIAFESARKRRHKVTSIDKAN-VLQSSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQF 240
Cdd:PRK08194  153 IQNAVFTRKGTERAMRYAFELAAKRRKHVTSATKSNgIVHSMPFWDEVFQEVGKDYPEIETDSQHIDALAAFFVTRPEEF 232

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352183597 241 DVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGF--GLYEPAGGSAPDIAGKNIANPIAQILSLALLLRYsLDADDA 318
Cdd:PRK08194  233 DVIVASNLFGDILTDIGAAIMGSIGIAPAANINVNGKypSMFEPVHGSAPDIAGKGIANPIGQIWTAKLMLDH-FGEEEL 311

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|
gi 1352183597 319 ACAIERAINRALEEGIRTGDLArGAAavSTDEMGD-IIAR 357
Cdd:PRK08194  312 GSHLLDVIEDVTEDGIKTPDIG-GRA--TTDEVTDeIISR 348
PRK08997 PRK08997
isocitrate dehydrogenase; Provisional
 7-357 1.75e-80

isocitrate dehydrogenase; Provisional


Pssm-ID: 181606  Cd Length: 334  Bit Score: 249.25  E-value: 1.75e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352183597   7 IAVLPGDGIGPEVMTQALKVLDAVRNRFAMRITtshyDVGGAAIDNHGQPLPPATVEGCEQADAVLFGSVGGPKWEHLPP 86
Cdd:PRK08997    5 ITVIPGDGIGPSIIDATLKILDKLGCDFEYEFA----DAGLTALEKHGELLPQRTLDLIEKNKIALKGPLTTPVGEGFTS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352183597  87 DQqpergalLPLRKHFKLFSNLRPAKLYQGLEAfcplRADiaanGFDILCVRELTGGIYFGQpkGREGSGQYEKAFDTEV 166
Cdd:PRK08997   81 IN-------VTLRKKFDLYANVRPVLSFPGTKA----RYD----NIDIITVRENTEGMYSGE--GQTVSEDGETAEATSI 143

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352183597 167 YHRFEIERIARIAFESARKR-RHKVTSIDKANVLQS-SILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFDVLL 244
Cdd:PRK08997  144 ITRKGAERIVRFAYELARKEgRKKVTAVHKANIMKStSGLFLKVAREVALRYPDIEFEEMIVDATCMQLVMNPEQFDVIV 223

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352183597 245 CSNLFGDILSDECAMITGSMGMLPSASLNEQGfGLYEPAGGSAPDIAGKNIANPIAQILSLALLLRYsLDADDAACAIER 324
Cdd:PRK08997  224 TTNLFGDILSDLCAGLVGGLGMAPGANIGRDA-AIFEAVHGSAPDIAGKNLANPTSVILAAIQMLEY-LGMPDKAERIRK 301

                         330       340       350
                  ....*....|....*....|....*....|....
gi 1352183597 325 AINRALEEGIR-TGDLarGAAAVSTDEMGDIIAR 357
Cdd:PRK08997  302 AIVAVIEAGDRtTRDL--GGTHGTTDFTQAVIDR 333
PRK09222 PRK09222
NADP-dependent isocitrate dehydrogenase;
1-357 1.05e-59

NADP-dependent isocitrate dehydrogenase;


Pssm-ID: 236416 [Multi-domain]  Cd Length: 482  Bit Score: 199.73  E-value: 1.05e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352183597   1 MSKNYHIAVLPGDGIGPEVMTQALKVLDAVRNRfaMRITTSHYdvgGAAIDNHGQP--LPPATVEGCEQADAVLFGSV-- 76
Cdd:PRK09222    1 MAEKTPITVAYGDGIGPEIMEAVLKILEAAGAP--LEIETIEI---GEKVYKKGWTsgISPSAWESIRRTKVLLKAPItt 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352183597  77 ---GGPKwehlppdqqperGALLPLRKHFKLFSNLRPAKLYqglEAFCPLRADiaanGFDILCVRE----LTGGIYFGQp 149
Cdd:PRK09222   76 pqgGGYK------------SLNVTLRKTLGLYANVRPCVSY---HPFVETKHP----NLDVVIIREneedLYAGIEHRQ- 135

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352183597 150 kgregsgqyekafDTEVYHRFEI------ERIARIAFESARKR-RHKVTSIDKANVL-QSSILWREIVNEIATEYPDVEL 221
Cdd:PRK09222  136 -------------TPDVYQCLKLisrpgsEKIIRYAFEYARANgRKKVTCLTKDNIMkLTDGLFHKVFDEIAKEYPDIEA 202

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352183597 222 AHMYIDNATMQLIKDPSQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGfGLYEPAGGSAPDIAGKNIANPIAQ 301
Cdd:PRK09222  203 EHYIVDIGAARLATNPENFDVIVTPNLYGDILSDIAAEISGSVGLAGSANIGEEY-AMFEAVHGSAPDIAGKNIANPSGL 281

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352183597 302 ILSLALLLRYsLDADDAACAIERAINRALEEGIRTGDL---ARGAAAVSTDEMGD-IIAR 357
Cdd:PRK09222  282 LNAAVMMLVH-IGQFDIAELIENAWLKTLEDGIHTADIyneGVSKKKVGTKEFAEaVIEN 340
PLN00118 PLN00118
isocitrate dehydrogenase (NAD+)
 9-349 7.16e-49

isocitrate dehydrogenase (NAD+)


Pssm-ID: 215062  Cd Length: 372  Bit Score: 168.52  E-value: 7.16e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352183597   9 VLPGDGIGPEVMTQALKVLDAVRNRFAMRittSHYDvgGAAIDNHGQplppaTVEGCEQADAVLFGSVG--GPKwehLPP 86
Cdd:PLN00118   46 LFPGDGIGPEIAESVKQVFTAAGVPIEWE---EHYV--GTTVDPRTG-----SFLTWESLESVRRNKVGlkGPM---ATP 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352183597  87 DQQPERGALLPLRKHFKLFSNLRPAKLYQGLEAfcplRADiaanGFDILCVRELTGGIYFGQpKGREGSGQYEKafdTEV 166
Cdd:PLN00118  113 IGKGHRSLNLTLRKELGLYANVRPCYSLPGYKT----RYD----DVDLVTIRENTEGEYSGL-EHQVVRGVVES---LKI 180

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352183597 167 YHRFEIERIARIAFESARKR-RHKVTSIDKANVLQSSI-LWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQFDVLL 244
Cdd:PLN00118  181 ITRQASLRVAEYAFHYAKTHgRKRVSAIHKANIMKKTDgLFLKCCREVAEKYPEIVYEEVIIDNCCMMLVKNPALFDVLV 260

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352183597 245 CSNLFGDILSDECAMITGSMGMLPSASLNEQGFGLYEPAGGSAPDIAGKNIANPIAQILSLALLLRYsLDADDAACAIER 324
Cdd:PLN00118  261 MPNLYGDIISDLCAGLIGGLGLTPSCNIGENGLALAEAVHGSAPDIAGKNLANPTALLLSAVMMLRH-LKLNEQAEQIHN 339

                         330       340
                  ....*....|....*....|....*.
gi 1352183597 325 AINRALEEG-IRTGDLarGAAAVSTD 349
Cdd:PLN00118  340 AILNTIAEGkYRTADL--GGSSTTTD 363
Icd COG0538
Isocitrate dehydrogenase [Energy production and conversion]; Isocitrate dehydrogenase is part ...
 12-357 7.91e-44

Isocitrate dehydrogenase [Energy production and conversion]; Isocitrate dehydrogenase is part of the Pathway/BioSystem: TCA cycle


Pssm-ID: 440304  Cd Length: 409  Bit Score: 156.04  E-value: 7.91e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352183597  12 GDGIGPEVMTQALKVLD-AVRNRFAM--RITTSHYDVGGAAIDNHGQPLPPATVEGCEQadavlFG-SVGGPkwehL-PP 86
Cdd:COG0538    26 GDGIGPEITRAIWKVIDaAVEKAYGGkrDIEWKEVDAGEKARDETGDWLPDETAEAIKE-----YGvGIKGP----LtTP 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352183597  87 DQQPER---GALlplRKHFKLFSNLRPAKLYQGLEAfcPLRAdiaANGFDILCVRELTGGIY------FGQPK------- 150
Cdd:COG0538    97 VGGGWRslnVTI---RQILDLYVCRRPVRYFKGVPS--PVKH---PEKVDIVIFRENTEDIYagiewkAGSPEalkliff 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352183597 151 GREGSGQYEKAFDTEV------YHRFEIERIARIAFESA--RKRRHkVTSIDKANvlqssIL------WREIVNEIA-TE 215
Cdd:COG0538   169 LEDEMGVTVIRFPEDSgigikpVSDEGTERLVRAAIQYAldNKRKS-VTLVHKGN-----IMkftegaFKDWGYEVAeEE 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352183597 216 YPDVELA-------------------HMYIDNATMQLIKDPSQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQG 276
Cdd:COG0538   243 FGDKFITegpwekykgpkpagkivykDRIADDMLQQILLRPGEYDVIATKNLNGDYISDALAAQVGGLGIAPGANIGDDG 322

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352183597 277 FGLYEPAGGSAPDIAGKNIANPIAQILSLALLLRYsLDADDAACAIERAINRALEEGIRTGDLAR---GAAAVSTDEMGD 353
Cdd:COG0538   323 GAEFEATHGTAPKYAGKDSTNPGSLILSGTMMLRH-RGWLEAADLIEKAVEKTIESGKVTYDLARlmeGATELSTSEFGD 401


                  ....*
gi 1352183597 354 -IIAR 357
Cdd:COG0538   402 aIIEN 406
PRK06451 PRK06451
NADP-dependent isocitrate dehydrogenase;
12-353 1.82e-40

NADP-dependent isocitrate dehydrogenase;


Pssm-ID: 235803  Cd Length: 412  Bit Score: 147.29  E-value: 1.82e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352183597  12 GDGIGPEVMTQALKVLD-AVRNRFAMRITTSHYDV--GGAAIDNHGQPLPPATVEGCEQADAVLFGSVGGP---KWehlp 85
Cdd:PRK06451   31 GDGIGPEITHAAMKVINkAVEKAYGSDREIKWVEVlaGDKAEKLTGNRFPKESEELIEKYRVLLKGPLETPigkGW---- 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352183597  86 pdqqpeRGALLPLRKHFKLFSNLRPAKLYQGLEAfcPLRAdiaANGFDILCVRELTGGIYFGqpkgregsgqYEKAFDTE 165
Cdd:PRK06451  107 ------KSINVAIRLMLDLYANIRPVKYIPGIES--PLKN---PEKIDLIIFRENTDDLYRG----------IEYPYDSE 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352183597 166 --------------------------VYHRFEIERIARIAFESA-RKRRHKVTSIDKANVLQ-SSILWREIVNEIAT-EY 216
Cdd:PRK06451  166 eakkirdflrkelgveveddtgigikLISKFKTQRIARMAIKYAiDHKRKKVTIMHKGNVMKyTEGAFREWAYEVALkEF 245

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352183597 217 PDV-----ELAHMYI---------------DNATMQLIKDPSQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQG 276
Cdd:PRK06451  246 RDYvvteeEVTKNYNgvppsgkviindriaDNMFQQIIIRPDEYDIILAPNVNGDYISDAAGALVGNIGMLGGANIGDTG 325

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1352183597 277 fGLYEPAGGSAPDIAGKNIANPIAQILSLALLLRYsLDADDAACAIERAINRALEEGIRTGDLAR--GAAAVSTDEMGD 353
Cdd:PRK06451  326 -GMFEAIHGTAPKYAGKNVANPTGIIKGGELMLRF-MGWDKAADLIDKAIMESIKQKKVTQDLARfmGVRALSTTEYTD 402
PLN00123 PLN00123
isocitrate dehydrogenase (NAD+)
 7-339 5.80e-33

isocitrate dehydrogenase (NAD+)


Pssm-ID: 215065  Cd Length: 360  Bit Score: 126.13  E-value: 5.80e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352183597   7 IAVLPGDGIGPEVMTQALKVLDAVRnrfaMRITTSHYDVGGAAIDnhgqpLPPATVEGCEQADAVLFGSVggpkwehlpp 86
Cdd:PLN00123   33 VTLIPGDGIGPLVTGAVEQVMEAMH----APVYFERYEVHGDMKK-----VPEEVLESIRRNKVCLKGGL---------- 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352183597  87 dQQPERGAL----LPLRKHFKLFSNLRPAKLYQGLeafcPLRADiaanGFDILCVRELTGGIYFG-QPKGREGSGQYEKa 161
Cdd:PLN00123   94 -ATPVGGGVsslnVQLRKELDLFASLVNCFNLPGL----PTRHE----NVDIVVIRENTEGEYSGlEHEVVPGVVESLK- 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352183597 162 fdteVYHRFEIERIARIAFESAR-KRRHKVTSIDKANVL-QSSILWREIVNEIATEYPDVELAHMYIDNATMQLIKDPSQ 239
Cdd:PLN00123  164 ----VITKFCSERIAKYAFEYAYlNNRKKVTAVHKANIMkLADGLFLESCREVAKKYPGIKYNEIIVDNCCMQLVSKPEQ 239

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352183597 240 FDVLLCSNLFGDILSDECAMITGSMGMLPSASLNeQGFGLYEpAGGSAPDIAGKNI-----ANPIAQILSLALLLRYsLD 314
Cdd:PLN00123  240 FDVMVTPNLYGNLVANTAAGIAGGTGVMPGGNVG-ADHAVFE-QGASAGNVGNEKLveqkkANPVALLLSSAMMLRH-LQ 316

                         330       340
                  ....*....|....*....|....*.
gi 1352183597 315 ADDAACAIERAINRALEEG-IRTGDL 339
Cdd:PLN00123  317 FPSFADRLETAVKRVIAEGkYRTKDL 342
PRK07006 PRK07006
isocitrate dehydrogenase; Reviewed
 7-355 7.40e-20

isocitrate dehydrogenase; Reviewed


Pssm-ID: 180792  Cd Length: 409  Bit Score: 90.12  E-value: 7.40e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352183597   7 IAVLPGDGIGPEVMTQALKVLDA-VRNRFAMRITTSHYDV--GGAAIDNHGQP--LPPATVEGCEQADAVLFGS----VG 77
Cdd:PRK07006   22 IPFIEGDGIGPDITPAMLKVVDAaVEKAYKGERKISWMEIyaGEKATKVYGEDvwLPEETLDLIREYRVAIKGPlttpVG 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352183597  78 GPKwehlppdqqpeRGALLPLRKHFKLFSNLRPAKLYQGLEAfcPLRAdiaANGFDILCVRELTGGIYFGQpKGREGSGQ 157
Cdd:PRK07006  102 GGI-----------RSLNVALRQELDLYVCLRPVRYFKGVPS--PVKR---PEDTDMVIFRENSEDIYAGI-EWKAGSAE 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352183597 158 YEKAFD--------TEVyhRFE--------------IERIARIAFESA-RKRRHKVTSIDKANVLQSS----------IL 204
Cdd:PRK07006  165 AKKVIKflqeemgvKKI--RFPetsgigikpvseegTERLVRAAIEYAiDNDRKSVTLVHKGNIMKFTegafkdwgyqLA 242

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352183597 205 WREIVNEIATEYPdvelaHMYIDNATMQ---LIKD-------------PSQFDVLLCSNLFGDILSDECAMITGSMGMLP 268
Cdd:PRK07006  243 EEEFGDELIDGGP-----WDKIKNPETGkeiIVKDsiadaflqqillrPAEYDVIATMNLNGDYISDALAAQVGGIGIAP 317

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352183597 269 SASLNEqGFGLYEPAGGSAPDIAGKNIANPIAQILSLALLLRYsLDADDAACAIERAINRALEEGIRTGDLAR---GAAA 345
Cdd:PRK07006  318 GANIND-GHAIFEATHGTAPKYAGLDKVNPGSVILSAEMMLRH-MGWTEAADLIIKSMEKTIASKTVTYDFARlmeGATE 395

                         410
                  ....*....|
gi 1352183597 346 VSTDEMGDII 355
Cdd:PRK07006  396 VKCSEFGDAL 405
PRK07362 PRK07362
NADP-dependent isocitrate dehydrogenase;
227-341 2.64e-11

NADP-dependent isocitrate dehydrogenase;


Pssm-ID: 180944  Cd Length: 474  Bit Score: 64.73  E-value: 2.64e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352183597 227 DNATMQLIKDPSQFDVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGfGLYEPAGGSAPDIAGKNIANPIAQILSLA 306
Cdd:PRK07362  340 DSIFQQIQTRPQEYSILATLNLNGDYISDAAAAIVGGLGMAPGANIGDNA-AIFEATHGTAPKHAGLDRINPGSVILSGV 418

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1352183597 307 LLLRYsLDADDAACAIERAINRALEEGIRTGDLAR 341
Cdd:PRK07362  419 MMLEY-LGWQEAADLITKGLSAAIANKQVTYDLAR 452
PTZ00435 PTZ00435
isocitrate dehydrogenase; Provisional
 223-357 6.77e-06

isocitrate dehydrogenase; Provisional


Pssm-ID: 240417  Cd Length: 413  Bit Score: 47.68  E-value: 6.77e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352183597 223 HMYIDNATMQLIKDPSQFdVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFG-LYEPAGGS------APDIAGKNI 295
Cdd:PTZ00435  249 HRLIDDMVAQAIKSEGGF-VWACKNYDGDVQSDIVAQGYGSLGLMTSVLVCPDGKTvEAEAAHGTvtrhyrQHQKGKETS 327

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1352183597 296 ANPIAQIL--SLALLLRYSLDADDA----ACAIERAINRALEEGIRTGDLA---RGAAAVS------TDEMGDIIAR 357
Cdd:PTZ00435  328 TNSIASIFawTRGLAHRAKLDNNQElvkfCQALERSCIETIEAGFMTKDLAicvHGSSKVTrsdylnTEEFIDKVAE 404
PLN00096 PLN00096
isocitrate dehydrogenase (NADP+); Provisional
 217-356 1.37e-04

isocitrate dehydrogenase (NADP+); Provisional


Pssm-ID: 177715  Cd Length: 393  Bit Score: 43.48  E-value: 1.37e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352183597 217 PDVELAHMYIDNATMQLIKDPSQFDVLLCSNLFGDILSDECAMITGSMGMLPS--ASLNEQGFGL--YEPAGGSAPD--- 289
Cdd:PLN00096  235 SGDELVHLLSDAATMKLVVWTDGGFGMAAHNYDGDVLTDELAQVHKSPGFITSnlVGVDENGTLIkeFEASHGTVTDmde 314

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1352183597 290 --IAGKNIA-NPIAQILSLALLLRYSLDADDAACAIE------RA-INRALEEGIRTGDLArGAAAVSTDEMGDIIA 356
Cdd:PLN00096  315 arLRGEETSlNPLGMVEGLIGAMNHAADVHGGKERVHpftaklRAvIHKLFREGRGTRDLC-GAGGLTTEQFIDAVA 390
PRK08299 PRK08299
NADP-dependent isocitrate dehydrogenase;
206-340 2.30e-04

NADP-dependent isocitrate dehydrogenase;


Pssm-ID: 236226  Cd Length: 402  Bit Score: 42.92  E-value: 2.30e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1352183597 206 REIVNEI-ATEYPD------VELAHMYIDNATMQLIKDPSQFdVLLCSNLFGDILSDECAMITGSMGMLPSASLNEQGFG 278
Cdd:PRK08299  222 KDIFQEVyEAEFKEkfeaagITYEHRLIDDMVASALKWEGGY-VWACKNYDGDVQSDTVAQGFGSLGLMTSVLMTPDGKT 300

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1352183597 279 L-YEPAGGSAPD-----IAGKNIA-NPIAQIL--SLALLLRYSLDADDA----ACAIERAINRALEEGIRTGDLA 340
Cdd:PRK08299  301 VeAEAAHGTVTRhyrqhQKGEETStNPIASIFawTRGLAHRGKLDGNPElvkfADTLEKVCIETVESGFMTKDLA 375
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH