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Conserved domains on  [gi|1388234245|gb|AWJ36126|]
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IS66 family insertion sequence hypothetical protein (plasmid) [Escherichia coli O103 str. RM8385]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
IS66_access_TnpA NF038385
IS66-like element accessory protein TnpA;
12-206 1.58e-105

IS66-like element accessory protein TnpA;


:

Pssm-ID: 439678 [Multi-domain]  Cd Length: 190  Bit Score: 302.02  E-value: 1.58e-105
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388234245  12 FRSYLPDALRLRFEDKLTIRAIAQRLGLSHSTIHTLFQRFIASGIAWPLPDSVSLAQLDAILYANRKKELT-EPQISEGT 90
Cdd:NF038385    1 YRTLLLDALRLRFDESLSYRAIGRQLGVSKSTIHSLFQRFLRAGLSWPLPDSMSADQLDAALYPNRKKPPSaPTVTRPVV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388234245  91 WRKERRASYSREFKVRLAKQALQPGAVVARIAREHGINDNLLFKWKSQYEDGLLSDDDIQECMPVPVALTDTPEPTRPVT 170
Cdd:NF038385   81 WKKIRRPNFSREFKIRLVEQTLQPGACVAQIARENGINDNLLFNWRHLYRNGLLQPDNEQETALLPVTLTPEPDPTIPVP 160

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 1388234245 171 NpfwrnkPDECPESDPGNVPRCELHLKSGVVKLFDP 206
Cdd:NF038385  161 A------QDPEQQNTTADSLCCELVLPAGTLRLFGP 190
 
Name Accession Description Interval E-value
IS66_access_TnpA NF038385
IS66-like element accessory protein TnpA;
12-206 1.58e-105

IS66-like element accessory protein TnpA;


Pssm-ID: 439678 [Multi-domain]  Cd Length: 190  Bit Score: 302.02  E-value: 1.58e-105
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388234245  12 FRSYLPDALRLRFEDKLTIRAIAQRLGLSHSTIHTLFQRFIASGIAWPLPDSVSLAQLDAILYANRKKELT-EPQISEGT 90
Cdd:NF038385    1 YRTLLLDALRLRFDESLSYRAIGRQLGVSKSTIHSLFQRFLRAGLSWPLPDSMSADQLDAALYPNRKKPPSaPTVTRPVV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388234245  91 WRKERRASYSREFKVRLAKQALQPGAVVARIAREHGINDNLLFKWKSQYEDGLLSDDDIQECMPVPVALTDTPEPTRPVT 170
Cdd:NF038385   81 WKKIRRPNFSREFKIRLVEQTLQPGACVAQIARENGINDNLLFNWRHLYRNGLLQPDNEQETALLPVTLTPEPDPTIPVP 160

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 1388234245 171 NpfwrnkPDECPESDPGNVPRCELHLKSGVVKLFDP 206
Cdd:NF038385  161 A------QDPEQQNTTADSLCCELVLPAGTLRLFGP 190
HTH_Tnp_1 pfam01527
Transposase; Transposase proteins are necessary for efficient DNA transposition. This family ...
 93-171 2.96e-21

Transposase; Transposase proteins are necessary for efficient DNA transposition. This family consists of various E. coli insertion elements and other bacterial transposases some of which are members of the IS3 family.


Pssm-ID: 426308 [Multi-domain]  Cd Length: 75  Bit Score: 83.56  E-value: 2.96e-21
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1388234245  93 KERRASYSREFKVRLAKQALQPGAVVARIAREHGINDNLLFKWKSQYEDGLLSDDDIqecmPVPVALTDTPEPTRPVTN 171
Cdd:pfam01527   1 MKKRRRFSEEFKLRAVKEVLEPGRTVKEVARRHGVSPNTLYQWRRQYEGGMGASPAR----PRLTALEEENRRLKRELA 75
InsE COG2963
Transposase InsE and inactivated derivatives [Mobilome: prophages, transposons];
93-142 9.96e-15

Transposase InsE and inactivated derivatives [Mobilome: prophages, transposons];


Pssm-ID: 442203 [Multi-domain]  Cd Length: 93  Bit Score: 67.26  E-value: 9.96e-15
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1388234245  93 KERRASYSREFKVRLAKQALQPGAVVARIAREHGINDNLLFKWKSQYEDG 142
Cdd:COG2963     2 SKKRRRYSPEFKAEAVRLVLEGGASVAEVARELGISPSTLYRWVRQYREG 51
transpos_IS3 NF033516
IS3 family transposase;
102-147 1.03e-08

IS3 family transposase;


Pssm-ID: 468052 [Multi-domain]  Cd Length: 369  Bit Score: 54.49  E-value: 1.03e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1388234245 102 EFKVRLAKQALQPGAVVARIAREHGINDNLLFKWKSQYEDGLLSDD 147
Cdd:NF033516    1 EFKLEAVREVLEGGKSVAEVARELGISPSTLYRWRKKYRGGGEAAD 46
PRK09413 PRK09413
IS2 repressor TnpA; Reviewed
 94-145 9.05e-07

IS2 repressor TnpA; Reviewed


Pssm-ID: 181833  Cd Length: 121  Bit Score: 46.33  E-value: 9.05e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1388234245  94 ERRASYSREFKVRLAKQALQPGAVVARIAREHGINDNLLFKWKSQYEDGLLS 145
Cdd:PRK09413    8 EKRRRRTTQEKIAIVQQSFEPGMTVSLVARQHGVAASQLFLWRKQYQEGSLT 59
transpos_IS21 NF033546
IS21 family transposase;
20-51 1.82e-03

IS21 family transposase;


Pssm-ID: 468077 [Multi-domain]  Cd Length: 296  Bit Score: 38.34  E-value: 1.82e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1388234245  20 LRLRFEDKLTIRAIAQRLGLSHSTIHTLFQRF 51
Cdd:NF033546    1 IRLLFRQGLSIREIARELGISRNTVRKYLRRA 32
transpos_IS630 NF033545
IS630 family transposase;
19-136 2.12e-03

IS630 family transposase;


Pssm-ID: 468076 [Multi-domain]  Cd Length: 298  Bit Score: 38.39  E-value: 2.12e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388234245  19 ALRLRfEDKLTIRAIAQRLGLSHSTIHTLFQRFIASGI--AWPLPDSVSLAQLDAILYANRKKELTEPQISE-GTW-RKE 94
Cdd:NF033545    5 ILLLA-AEGLSITEIAERLGVSRSTVYRWLKRFNEGGLegLLDKPRPGRPRKLLSEQQAELLALLLEEPPEGaGHWtLRE 83

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1388234245  95 RRASYSREFKVRLAKQALQpgavvaRIAREHGindnllFKWK 136
Cdd:NF033545   84 LAALLEEEFGVEYSRSTVR------RLLKRLG------LSPK 113
 
Name Accession Description Interval E-value
IS66_access_TnpA NF038385
IS66-like element accessory protein TnpA;
12-206 1.58e-105

IS66-like element accessory protein TnpA;


Pssm-ID: 439678 [Multi-domain]  Cd Length: 190  Bit Score: 302.02  E-value: 1.58e-105
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388234245  12 FRSYLPDALRLRFEDKLTIRAIAQRLGLSHSTIHTLFQRFIASGIAWPLPDSVSLAQLDAILYANRKKELT-EPQISEGT 90
Cdd:NF038385    1 YRTLLLDALRLRFDESLSYRAIGRQLGVSKSTIHSLFQRFLRAGLSWPLPDSMSADQLDAALYPNRKKPPSaPTVTRPVV 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388234245  91 WRKERRASYSREFKVRLAKQALQPGAVVARIAREHGINDNLLFKWKSQYEDGLLSDDDIQECMPVPVALTDTPEPTRPVT 170
Cdd:NF038385   81 WKKIRRPNFSREFKIRLVEQTLQPGACVAQIARENGINDNLLFNWRHLYRNGLLQPDNEQETALLPVTLTPEPDPTIPVP 160

                         170       180       190
                  ....*....|....*....|....*....|....*.
gi 1388234245 171 NpfwrnkPDECPESDPGNVPRCELHLKSGVVKLFDP 206
Cdd:NF038385  161 A------QDPEQQNTTADSLCCELVLPAGTLRLFGP 190
HTH_Tnp_1 pfam01527
Transposase; Transposase proteins are necessary for efficient DNA transposition. This family ...
 93-171 2.96e-21

Transposase; Transposase proteins are necessary for efficient DNA transposition. This family consists of various E. coli insertion elements and other bacterial transposases some of which are members of the IS3 family.


Pssm-ID: 426308 [Multi-domain]  Cd Length: 75  Bit Score: 83.56  E-value: 2.96e-21
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1388234245  93 KERRASYSREFKVRLAKQALQPGAVVARIAREHGINDNLLFKWKSQYEDGLLSDDDIqecmPVPVALTDTPEPTRPVTN 171
Cdd:pfam01527   1 MKKRRRFSEEFKLRAVKEVLEPGRTVKEVARRHGVSPNTLYQWRRQYEGGMGASPAR----PRLTALEEENRRLKRELA 75
InsE COG2963
Transposase InsE and inactivated derivatives [Mobilome: prophages, transposons];
93-142 9.96e-15

Transposase InsE and inactivated derivatives [Mobilome: prophages, transposons];


Pssm-ID: 442203 [Multi-domain]  Cd Length: 93  Bit Score: 67.26  E-value: 9.96e-15
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 1388234245  93 KERRASYSREFKVRLAKQALQPGAVVARIAREHGINDNLLFKWKSQYEDG 142
Cdd:COG2963     2 SKKRRRYSPEFKAEAVRLVLEGGASVAEVARELGISPSTLYRWVRQYREG 51
transpos_IS3 NF033516
IS3 family transposase;
102-147 1.03e-08

IS3 family transposase;


Pssm-ID: 468052 [Multi-domain]  Cd Length: 369  Bit Score: 54.49  E-value: 1.03e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 1388234245 102 EFKVRLAKQALQPGAVVARIAREHGINDNLLFKWKSQYEDGLLSDD 147
Cdd:NF033516    1 EFKLEAVREVLEGGKSVAEVARELGISPSTLYRWRKKYRGGGEAAD 46
PRK09413 PRK09413
IS2 repressor TnpA; Reviewed
 94-145 9.05e-07

IS2 repressor TnpA; Reviewed


Pssm-ID: 181833  Cd Length: 121  Bit Score: 46.33  E-value: 9.05e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1388234245  94 ERRASYSREFKVRLAKQALQPGAVVARIAREHGINDNLLFKWKSQYEDGLLS 145
Cdd:PRK09413    8 EKRRRRTTQEKIAIVQQSFEPGMTVSLVARQHGVAASQLFLWRKQYQEGSLT 59
HTH_23 pfam13384
Homeodomain-like domain;
19-57 1.65e-04

Homeodomain-like domain;


Pssm-ID: 433164 [Multi-domain]  Cd Length: 50  Bit Score: 38.40  E-value: 1.65e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1388234245  19 ALRLrFEDKLTIRAIAQRLGLSHSTIHTLFQRFIASGIA 57
Cdd:pfam13384  10 ALLL-LAEGLSVKEIAELLGVSRRTVYRWLKRYNEEGLE 47
transpos_IS21 NF033546
IS21 family transposase;
20-51 1.82e-03

IS21 family transposase;


Pssm-ID: 468077 [Multi-domain]  Cd Length: 296  Bit Score: 38.34  E-value: 1.82e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1388234245  20 LRLRFEDKLTIRAIAQRLGLSHSTIHTLFQRF 51
Cdd:NF033546    1 IRLLFRQGLSIREIARELGISRNTVRKYLRRA 32
DeoR COG2390
DNA-binding transcriptional regulator LsrR, DeoR family [Transcription];
19-68 1.95e-03

DNA-binding transcriptional regulator LsrR, DeoR family [Transcription];


Pssm-ID: 441955 [Multi-domain]  Cd Length: 301  Bit Score: 38.57  E-value: 1.95e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1388234245  19 ALRLRFEDKLTIRAIAQRLGLSHSTIHTLFQRFIASG-----IAWPLPDSVSLAQ 68
Cdd:COG2390     2 AAWLYYVEGLTQREIAERLGISRRTVSRLLAEAREEGlvrisITDPLAGLLELER 56
transpos_IS630 NF033545
IS630 family transposase;
19-136 2.12e-03

IS630 family transposase;


Pssm-ID: 468076 [Multi-domain]  Cd Length: 298  Bit Score: 38.39  E-value: 2.12e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388234245  19 ALRLRfEDKLTIRAIAQRLGLSHSTIHTLFQRFIASGI--AWPLPDSVSLAQLDAILYANRKKELTEPQISE-GTW-RKE 94
Cdd:NF033545    5 ILLLA-AEGLSITEIAERLGVSRSTVYRWLKRFNEGGLegLLDKPRPGRPRKLLSEQQAELLALLLEEPPEGaGHWtLRE 83

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|..
gi 1388234245  95 RRASYSREFKVRLAKQALQpgavvaRIAREHGindnllFKWK 136
Cdd:NF033545   84 LAALLEEEFGVEYSRSTVR------RLLKRLG------LSPK 113
HTH_40 pfam14493
Helix-turn-helix domain; This presumed domain is found at the C-terminus of a large number of ...
 24-87 2.39e-03

Helix-turn-helix domain; This presumed domain is found at the C-terminus of a large number of helicase proteins.


Pssm-ID: 464189  Cd Length: 89  Bit Score: 35.95  E-value: 2.39e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1388234245  24 FEDKLTIRAIAQRLGLSHSTIHTLFQRFIASGIAWPLPDSVSLAQLDAILYANRK---------KELTEPQIS 87
Cdd:pfam14493   9 YKEGLSIEEIAEERGLKESTIEGHLAELIEAGEPVDIERLVSEEEQKEILDAIEKlgseslkpiKEALPEEIS 81
Csa3 COG3415
CRISPR-associated protein Csa3, CARF domain [Defense mechanisms]; CRISPR-associated protein ...
 22-127 3.47e-03

CRISPR-associated protein Csa3, CARF domain [Defense mechanisms]; CRISPR-associated protein Csa3, CARF domain is part of the Pathway/BioSystem: CRISPR-Cas system


Pssm-ID: 442641 [Multi-domain]  Cd Length: 325  Bit Score: 37.91  E-value: 3.47e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388234245  22 LRFEDKLTIRAIAQRLGLSHSTIHTLFQRFIASGIAWPLPDS-------VSLAQLDAILyanrkKELTEPQISEGT-WRK 93
Cdd:COG3415    33 LLLAEGLSVREIAERLGVSRSTVYRWLKRYREGGLAGLKDRPrggrpskLSDEQRERLL-----ELLREKSPDQGSrWTL 107

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1388234245  94 ERRASY-SREFKVRLAKQAlqpgavVARIAREHGI 127
Cdd:COG3415   108 AELAELlEEEFGVEVSPST------VRRLLKRLGL 136
MarR_2 pfam12802
MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a ...
 22-55 3.85e-03

MarR family; The Mar proteins are involved in the multiple antibiotic resistance, a non-specific resistance system. The expression of the mar operon is controlled by a repressor, MarR. A large number of compounds induce transcription of the mar operon. This is thought to be due to the compound binding to MarR, and the resulting complex stops MarR binding to the DNA. With the MarR repression lost, transcription of the operon proceeds. The structure of MarR is known and shows MarR as a dimer with each subunit containing a winged-helix DNA binding motif.


Pssm-ID: 432797 [Multi-domain]  Cd Length: 60  Bit Score: 34.87  E-value: 3.85e-03
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1388234245  22 LRFEDKLTIRAIAQRLGLSHSTIHTLFQRFIASG 55
Cdd:pfam12802  14 LARNPGLTVAELARRLGISKQTVSRLVKRLEAKG 47
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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