Colicin-like bacteriocin tRNase domain; The C-terminal region of colicin-like bacteriocins is ...
1-309
7.02e-108
Colicin-like bacteriocin tRNase domain; The C-terminal region of colicin-like bacteriocins is either a pore-forming or an endonuclease-like domain. Cloacin and Pyocins have similar structures and activities to the colicins from E coli and the klebicins from Klebsiella spp. Colicins E5 and D cleave the anticodon loops of distinct tRNAs of Escherichia coli both in vivo and in vitro. The full-length molecule has an N-terminal translocation domain and a middle, double alpha-helical region which is receptor-binding.
:
Pssm-ID: 367536 Cd Length: 273 Bit Score: 328.41 E-value: 7.02e-108
S-type Pyocin; This family represents a conserved region approximately 180 residues long ...
452-590
9.76e-35
S-type Pyocin; This family represents a conserved region approximately 180 residues long within bacterial S-type pyocins. Pyocins are polypeptide toxins produced by, and active against, bacteria. S-type pyocins cause cell death by DNA breakdown due to endonuclease activity.
:
Pssm-ID: 399737 Cd Length: 139 Bit Score: 128.64 E-value: 9.76e-35
Colicin D; Colicin D is a tRNase which kills sensitive E.coli cells via a specific tRNA ...
604-684
2.27e-25
Colicin D; Colicin D is a tRNase which kills sensitive E.coli cells via a specific tRNA cleavage. It targets the four isoaccepting tRNAs for Arg and cleaves the phosphodiester bond between positions 38 and 39 at the 3' junction of the anticodon stem and the loop.
The actual alignment was detected with superfamily member pfam11429:
Pssm-ID: 463278 Cd Length: 85 Bit Score: 99.95 E-value: 2.27e-25
Colicin-like bacteriocin tRNase domain; The C-terminal region of colicin-like bacteriocins is ...
1-309
7.02e-108
Colicin-like bacteriocin tRNase domain; The C-terminal region of colicin-like bacteriocins is either a pore-forming or an endonuclease-like domain. Cloacin and Pyocins have similar structures and activities to the colicins from E coli and the klebicins from Klebsiella spp. Colicins E5 and D cleave the anticodon loops of distinct tRNAs of Escherichia coli both in vivo and in vitro. The full-length molecule has an N-terminal translocation domain and a middle, double alpha-helical region which is receptor-binding.
Pssm-ID: 367536 Cd Length: 273 Bit Score: 328.41 E-value: 7.02e-108
S-type Pyocin; This family represents a conserved region approximately 180 residues long ...
452-590
9.76e-35
S-type Pyocin; This family represents a conserved region approximately 180 residues long within bacterial S-type pyocins. Pyocins are polypeptide toxins produced by, and active against, bacteria. S-type pyocins cause cell death by DNA breakdown due to endonuclease activity.
Pssm-ID: 399737 Cd Length: 139 Bit Score: 128.64 E-value: 9.76e-35
Colicin D; Colicin D is a tRNase which kills sensitive E.coli cells via a specific tRNA ...
604-684
2.27e-25
Colicin D; Colicin D is a tRNase which kills sensitive E.coli cells via a specific tRNA cleavage. It targets the four isoaccepting tRNAs for Arg and cleaves the phosphodiester bond between positions 38 and 39 at the 3' junction of the anticodon stem and the loop.
Pssm-ID: 463278 Cd Length: 85 Bit Score: 99.95 E-value: 2.27e-25
Colicin-like bacteriocin tRNase domain; The C-terminal region of colicin-like bacteriocins is ...
1-309
7.02e-108
Colicin-like bacteriocin tRNase domain; The C-terminal region of colicin-like bacteriocins is either a pore-forming or an endonuclease-like domain. Cloacin and Pyocins have similar structures and activities to the colicins from E coli and the klebicins from Klebsiella spp. Colicins E5 and D cleave the anticodon loops of distinct tRNAs of Escherichia coli both in vivo and in vitro. The full-length molecule has an N-terminal translocation domain and a middle, double alpha-helical region which is receptor-binding.
Pssm-ID: 367536 Cd Length: 273 Bit Score: 328.41 E-value: 7.02e-108
S-type Pyocin; This family represents a conserved region approximately 180 residues long ...
452-590
9.76e-35
S-type Pyocin; This family represents a conserved region approximately 180 residues long within bacterial S-type pyocins. Pyocins are polypeptide toxins produced by, and active against, bacteria. S-type pyocins cause cell death by DNA breakdown due to endonuclease activity.
Pssm-ID: 399737 Cd Length: 139 Bit Score: 128.64 E-value: 9.76e-35
Colicin D; Colicin D is a tRNase which kills sensitive E.coli cells via a specific tRNA ...
604-684
2.27e-25
Colicin D; Colicin D is a tRNase which kills sensitive E.coli cells via a specific tRNA cleavage. It targets the four isoaccepting tRNAs for Arg and cleaves the phosphodiester bond between positions 38 and 39 at the 3' junction of the anticodon stem and the loop.
Pssm-ID: 463278 Cd Length: 85 Bit Score: 99.95 E-value: 2.27e-25
Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
References:
Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
of the residues that compose this conserved feature have been mapped to the query sequence.
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