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Conserved domains on  [gi|1476636197|gb|AXZ47804|]
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MATE family efflux transporter [Citrobacter freundii]

Protein Classification

MATE family efflux transporter( domain architecture ID 11484604)

MATE (multidrug and toxic compound extrusion) family efflux transporter functions in protecting cells against oxidative stress and bile salts and may be part of the SOS system; similar to Escherichia coli FMN/FAD exporter YeeO

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
PRK10189 PRK10189
EmmdR/YeeO family multidrug/toxin efflux MATE transporter;
1-478 0e+00

EmmdR/YeeO family multidrug/toxin efflux MATE transporter;


:

Pssm-ID: 182293 [Multi-domain]  Cd Length: 478  Bit Score: 827.84  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476636197   1 MNVSAALRQVASRTPWYAKRKSYKVLFWREITPLAVPIFLENTCVLLMGVLSTFLVSWLGKEAMAGVGLADSFNMVIMAF 80
Cdd:PRK10189    1 LNISSALRQVVHGTRWYAKRKSYRVLFWREITPLAVPIFIENLCVLLMGVLSTFLVSWLGKEAMAGVGLADSFNMVIMAF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476636197  81 FAAIDLGTTVVVAFSLGKRDRRRARAAARQSLVIMTIFATVLAAVIHYFGQQIIDVVAGEATPDVKALALTYLELTVLSY 160
Cdd:PRK10189   81 FAAIDLGTTVVVAFSLGKRDRRRARAAARQSLVIMTLFAVLLAVLIHFFGEQIIDLVAGDATPEVKALALTYLELTVWSY 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476636197 161 PAAAIALIGSGALRGAGNTKIPLLINGGMNILNIIISSILIYGIFSWQGLGFVGAGLGLTISRYIGAIAIIWVLMIGFNP 240
Cdd:PRK10189  161 PAAAITLIGSGALRGAGNTKIPLLINGGMNILNIIISSILIYGLFSWQGLGFVGAGLGLTISRYIGAVAIIWVLMIGFNP 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476636197 241 ALRIPFKSYFKPLNLAIIWEVMGIGIPASIESVLFNGGKLLTQMFVSGMGTSVIAGNFIAFSIAALINLPGNALGSASTI 320
Cdd:PRK10189  241 ALRISLKSYFKPLNFAIIWEVMGIGIPASIESVLFNGGKLLTQMFVAGMGTSVIAGNFIAFSIAALINLPGNALGSASTI 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476636197 321 ITGRRLGNGQIAQAEIQLRHVFWLSTIGLTAIAWLTAPFAGVMASFYTHDQDVKEVIVILIWLNAAFMPIWAASWVLPAG 400
Cdd:PRK10189  321 ITGTRLGKGQIAQAERQLRHVFWLSTLGLTAIAWLSAPFAGLLASFYTQDPDVKHVVKILIWLNALFMPIWAASWVLPAG 400
                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1476636197 401 FKGARDARFAMWVSMLGMWGCRVVAGYTLGIVLGWGVVGVWLGMFFDWAVRAALFYWRMVTGRWLWKYPRPEREKCIK 478
Cdd:PRK10189  401 LKGARDARYAMWVSMLGMWGCRVVAGYILGIMLGFGVVGVWMGMFLDWAVRGVLFYWRMVSGRWLWKYPRPEPQKCEK 478
 
Name Accession Description Interval E-value
PRK10189 PRK10189
EmmdR/YeeO family multidrug/toxin efflux MATE transporter;
1-478 0e+00

EmmdR/YeeO family multidrug/toxin efflux MATE transporter;


Pssm-ID: 182293 [Multi-domain]  Cd Length: 478  Bit Score: 827.84  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476636197   1 MNVSAALRQVASRTPWYAKRKSYKVLFWREITPLAVPIFLENTCVLLMGVLSTFLVSWLGKEAMAGVGLADSFNMVIMAF 80
Cdd:PRK10189    1 LNISSALRQVVHGTRWYAKRKSYRVLFWREITPLAVPIFIENLCVLLMGVLSTFLVSWLGKEAMAGVGLADSFNMVIMAF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476636197  81 FAAIDLGTTVVVAFSLGKRDRRRARAAARQSLVIMTIFATVLAAVIHYFGQQIIDVVAGEATPDVKALALTYLELTVLSY 160
Cdd:PRK10189   81 FAAIDLGTTVVVAFSLGKRDRRRARAAARQSLVIMTLFAVLLAVLIHFFGEQIIDLVAGDATPEVKALALTYLELTVWSY 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476636197 161 PAAAIALIGSGALRGAGNTKIPLLINGGMNILNIIISSILIYGIFSWQGLGFVGAGLGLTISRYIGAIAIIWVLMIGFNP 240
Cdd:PRK10189  161 PAAAITLIGSGALRGAGNTKIPLLINGGMNILNIIISSILIYGLFSWQGLGFVGAGLGLTISRYIGAVAIIWVLMIGFNP 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476636197 241 ALRIPFKSYFKPLNLAIIWEVMGIGIPASIESVLFNGGKLLTQMFVSGMGTSVIAGNFIAFSIAALINLPGNALGSASTI 320
Cdd:PRK10189  241 ALRISLKSYFKPLNFAIIWEVMGIGIPASIESVLFNGGKLLTQMFVAGMGTSVIAGNFIAFSIAALINLPGNALGSASTI 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476636197 321 ITGRRLGNGQIAQAEIQLRHVFWLSTIGLTAIAWLTAPFAGVMASFYTHDQDVKEVIVILIWLNAAFMPIWAASWVLPAG 400
Cdd:PRK10189  321 ITGTRLGKGQIAQAERQLRHVFWLSTLGLTAIAWLSAPFAGLLASFYTQDPDVKHVVKILIWLNALFMPIWAASWVLPAG 400
                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1476636197 401 FKGARDARFAMWVSMLGMWGCRVVAGYTLGIVLGWGVVGVWLGMFFDWAVRAALFYWRMVTGRWLWKYPRPEREKCIK 478
Cdd:PRK10189  401 LKGARDARYAMWVSMLGMWGCRVVAGYILGIMLGFGVVGVWMGMFLDWAVRGVLFYWRMVSGRWLWKYPRPEPQKCEK 478
MATE_NorM_like cd13137
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ...
29-465 7.45e-100

Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240542 [Multi-domain]  Cd Length: 432  Bit Score: 306.36  E-value: 7.45e-100
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476636197  29 REITPLAVPIFLENTCVLLMGVLSTFLVSWLGKEAMAGVGLADSFNMVIMAFFAAIDLGTTVVVAFSLGKRDRRRARAAA 108
Cdd:cd13137     1 RRIWSLAWPVILENLLQTLVGLVDVFMVGRLGAEAIAAVGLATQVLWLLLVLNMALGTGTVALVSQSYGAGDYERARRAL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476636197 109 RQSLVIMTIFATVLAAVIHYFGQQIIDVVAgeATPDVKALALTYLELTVLSYPAAAIALIGSGALRGAGNTKIPLLINGG 188
Cdd:cd13137    81 GQSLLLALLLSLPLALLGLLFAEPLLRLLG--ADPEVIALALTYLRIVLLGIPFFFLSLVGNAALRGAGDTKTPMYIMII 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476636197 189 MNILNIIISSILIYGIFSWQGLGFVGAGLGLTISRYIGAIAIIWVLMIGFNPalrIPFKSYFKPLNLAIIWEVMGIGIPA 268
Cdd:cd13137   159 VNVLNIVLDYVLIFGLWGFPGLGVAGAALATVISRVVGALLLLFLLLRGRLP---IKISFKGFRLDRKIIKKLLRIGLPA 235
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476636197 269 SIESVLFNGGKLLTQMFVSGMGTSVIAGNFIAFSIAALINLPGNALGSASTIITGRRLGNGQIAQAEIQLRHVFWLSTIG 348
Cdd:cd13137   236 GLEQLLRSLGFLVLLAIVASYGTAALAAYQIGLRIESLAFMPGFGFSMAASTLVGQNLGAGDPDEARRYGKRALRLGVLF 315
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476636197 349 LTAIAWLTAPFAGVMASFYTHDQDVKEVIVILIWLNAAFMPIWAASWVLPAGFKGARDARFAMWVSMLGMWGCRVVAGYT 428
Cdd:cd13137   316 MGLLGLLLFIFAPPLASLFTPDPEVIELGVLYLRIVALSQPFLAISFVLSGALRGAGDTRPPLIINLISMWLVRLPLAYL 395
                         410       420       430
                  ....*....|....*....|....*....|....*..
gi 1476636197 429 LGIVLGWGVVGVWLGMFFDWAVRAALFYWRMVTGRWL 465
Cdd:cd13137   396 LGFVLGLGLTGIWLAMFVDTIVRAILLLYRFRKGKWK 432
NorM COG0534
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];
27-458 9.85e-73

Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];


Pssm-ID: 440300 [Multi-domain]  Cd Length: 427  Bit Score: 236.19  E-value: 9.85e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476636197  27 FWREITPLAVPIFLENTCVLLMGVLSTFLVSWLGKEAMAGVGLADSFNMVIMAFFAAIDLGTTVVVAFSLGKRDRRRARA 106
Cdd:COG0534     6 ILKLLLRLALPIILGNLLQSLYGLVDTIFVGRLGTAALAAVGLAFPIFFLLIALGIGLGVGGTALVAQALGAGDREEARR 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476636197 107 AARQSLVIMTIFATVLAAVIHYFGQQIIDVVAgeATPDVKALALTYLELTVLSYPAAAIALIGSGALRGAGNTKIPLLIN 186
Cdd:COG0534    86 VLGQALLLALLLGLLLTLLGLLFAPPLLRLLG--ADPEVLALARDYLRIILLGLPFLLLFNVLNGILRGLGDTKTPMIIM 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476636197 187 GGMNILNIIISSILIYGIfswqGLGFVGAGLGLTISRYIGAIAIIWVLMIGFNPaLRIPFKSYfkPLNLAIIWEVMGIGI 266
Cdd:COG0534   164 LIGNVLNIVLDPLLIFGG----GLGVAGAALATVISQAVSALLLLYYLFRKRSL-LRLRLRDL--RPDRKILKRILRIGL 236
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476636197 267 PASIESVLFNGGKLLTQMFVSGMGTSVIAGNFIAFSIAALINLPGNALGSASTIITGRRLGNGQIAQAEIQLRHVFWLST 346
Cdd:COG0534   237 PAGLQQLAESLGFLVLNALVARLGTAAVAAYGIALRIESLAFMPALGLGQAAQPLVGQNLGAGDYDRARRAARLALLLAL 316
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476636197 347 IGLTAIAWLTAPFAGVMASFYTHDQDVKEVIVILIWLNAAFMPIWAASWVLPAGFKGARDARFAMWVSMLGMWGCRVVAG 426
Cdd:COG0534   317 GIGLLLALLLFLFPEPIIGLFTDDPEVIALAATYLRIAALFQPFDGLQFVLSGALRGAGDTRFPMIISLLRLWLVRLPLA 396
                         410       420       430
                  ....*....|....*....|....*....|..
gi 1476636197 427 YTLGIvLGWGVVGVWLGMFFDWAVRAALFYWR 458
Cdd:COG0534   397 YLLAF-LGLGLTGVWLALPIGEVLRALLLLLR 427
matE TIGR00797
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A. ...
37-383 8.53e-33

putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A.66) The MATE family consists of probable efflux proteins including a functionally characterized multi drug efflux system from Vibrio parahaemolyticus, a putative ethionine resistance protein of Saccharomyces cerevisiae, and the functionally uncharacterized DNA damage-inducible protein F (DinF) of E. coli. These proteins have 12 probable TMS. [Transport and binding proteins, Other]


Pssm-ID: 273273 [Multi-domain]  Cd Length: 342  Bit Score: 127.36  E-value: 8.53e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476636197  37 PIFLENTCVLLMGVLSTFLVSWLGKEAMAGVGLADSFNMVIMAFFAAIDLGTTVVVAFSLGKRDRRRARAAARQSLVIMT 116
Cdd:TIGR00797   1 PAILANILQPLLGLVDTAFVGHLGPVDLAAVSLGSSVFMFLFSILMGLGTATTALVAQAVGAGNYQRLGRQAQQSLLLAL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476636197 117 IFATVLAAVIHYFGQQIIDvvAGEATPDVKALALTYLELTVLSYPAAAIALIGSGALRGAGNTKIPLLINGGMNILNIII 196
Cdd:TIGR00797  81 LLGLPVLLVGYFFIDPLLS--LMGADGEVAELAQDYLRILILGIPAYLLNFVLRGFLRGQGDTKTPMYITLIGNVINIIL 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476636197 197 SSILIYGIFSWqgLGFVGAGLGLTISRYIGAIAIIWVLMIGfnPALRIPFKSYFKPlNLAIIWEVMGIGIPASIESVLFN 276
Cdd:TIGR00797 159 NYILIFGKFGF--LGIVGAALATVISYWLMFLLLLYYIKKA--KKIGLKWEGLLKP-DWEVLKRLLKLGLPIAFRVILES 233
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476636197 277 GGKLLTQMFVSGMGTSVIAGNFIAFSIAALINLPGNALGSASTIITGRRLGNGQIAQAEIQLRHVFWLSTIGLTAIAWLT 356
Cdd:TIGR00797 234 LSFALLALLVARLGSIALAAHQIALNVESLLFMPAFGFGIAVSILVGQALGAGDPKRAKEVARVALKLSLLLGLVLAIIL 313
                         330       340
                  ....*....|....*....|....*..
gi 1476636197 357 APFAGVMASFYTHDQDVKEVIVILIWL 383
Cdd:TIGR00797 314 ILFREFIARLFTNDPEVLELAAIYLIF 340
MatE pfam01554
MatE; The MatE domain
37-187 1.40e-21

MatE; The MatE domain


Pssm-ID: 334587 [Multi-domain]  Cd Length: 161  Bit Score: 91.09  E-value: 1.40e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476636197  37 PIFLENTCVLLMGVLSTFLVSWLGKEAMAGVGLADSFNMVIMAFFAAIDLGTTVVVAFSLGKRDRRRARAAARQSLVIMT 116
Cdd:pfam01554   1 PIALENLLQSLYSLIDTLFVGHLGAVALAAVSIANSIASLIFMFLLGLGTALTTLVGQALGAGNFKRAGVALRQGLILGL 80
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1476636197 117 IFATVLAAVIHYFGQQIIDVVAGEatPDVKALALTYLELTVLSYPAAAIALIGSGALRGAGNTKIPLLING 187
Cdd:pfam01554  81 LLSLPIALLVLLFSEPILSLFGQD--EEVLALAKRYLRILILGIPFYALQFVLSGFLRGQGDTKPPMYINI 149
 
Name Accession Description Interval E-value
PRK10189 PRK10189
EmmdR/YeeO family multidrug/toxin efflux MATE transporter;
1-478 0e+00

EmmdR/YeeO family multidrug/toxin efflux MATE transporter;


Pssm-ID: 182293 [Multi-domain]  Cd Length: 478  Bit Score: 827.84  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476636197   1 MNVSAALRQVASRTPWYAKRKSYKVLFWREITPLAVPIFLENTCVLLMGVLSTFLVSWLGKEAMAGVGLADSFNMVIMAF 80
Cdd:PRK10189    1 LNISSALRQVVHGTRWYAKRKSYRVLFWREITPLAVPIFIENLCVLLMGVLSTFLVSWLGKEAMAGVGLADSFNMVIMAF 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476636197  81 FAAIDLGTTVVVAFSLGKRDRRRARAAARQSLVIMTIFATVLAAVIHYFGQQIIDVVAGEATPDVKALALTYLELTVLSY 160
Cdd:PRK10189   81 FAAIDLGTTVVVAFSLGKRDRRRARAAARQSLVIMTLFAVLLAVLIHFFGEQIIDLVAGDATPEVKALALTYLELTVWSY 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476636197 161 PAAAIALIGSGALRGAGNTKIPLLINGGMNILNIIISSILIYGIFSWQGLGFVGAGLGLTISRYIGAIAIIWVLMIGFNP 240
Cdd:PRK10189  161 PAAAITLIGSGALRGAGNTKIPLLINGGMNILNIIISSILIYGLFSWQGLGFVGAGLGLTISRYIGAVAIIWVLMIGFNP 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476636197 241 ALRIPFKSYFKPLNLAIIWEVMGIGIPASIESVLFNGGKLLTQMFVSGMGTSVIAGNFIAFSIAALINLPGNALGSASTI 320
Cdd:PRK10189  241 ALRISLKSYFKPLNFAIIWEVMGIGIPASIESVLFNGGKLLTQMFVAGMGTSVIAGNFIAFSIAALINLPGNALGSASTI 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476636197 321 ITGRRLGNGQIAQAEIQLRHVFWLSTIGLTAIAWLTAPFAGVMASFYTHDQDVKEVIVILIWLNAAFMPIWAASWVLPAG 400
Cdd:PRK10189  321 ITGTRLGKGQIAQAERQLRHVFWLSTLGLTAIAWLSAPFAGLLASFYTQDPDVKHVVKILIWLNALFMPIWAASWVLPAG 400
                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1476636197 401 FKGARDARFAMWVSMLGMWGCRVVAGYTLGIVLGWGVVGVWLGMFFDWAVRAALFYWRMVTGRWLWKYPRPEREKCIK 478
Cdd:PRK10189  401 LKGARDARYAMWVSMLGMWGCRVVAGYILGIMLGFGVVGVWMGMFLDWAVRGVLFYWRMVSGRWLWKYPRPEPQKCEK 478
MATE_NorM_like cd13137
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ...
29-465 7.45e-100

Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240542 [Multi-domain]  Cd Length: 432  Bit Score: 306.36  E-value: 7.45e-100
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476636197  29 REITPLAVPIFLENTCVLLMGVLSTFLVSWLGKEAMAGVGLADSFNMVIMAFFAAIDLGTTVVVAFSLGKRDRRRARAAA 108
Cdd:cd13137     1 RRIWSLAWPVILENLLQTLVGLVDVFMVGRLGAEAIAAVGLATQVLWLLLVLNMALGTGTVALVSQSYGAGDYERARRAL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476636197 109 RQSLVIMTIFATVLAAVIHYFGQQIIDVVAgeATPDVKALALTYLELTVLSYPAAAIALIGSGALRGAGNTKIPLLINGG 188
Cdd:cd13137    81 GQSLLLALLLSLPLALLGLLFAEPLLRLLG--ADPEVIALALTYLRIVLLGIPFFFLSLVGNAALRGAGDTKTPMYIMII 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476636197 189 MNILNIIISSILIYGIFSWQGLGFVGAGLGLTISRYIGAIAIIWVLMIGFNPalrIPFKSYFKPLNLAIIWEVMGIGIPA 268
Cdd:cd13137   159 VNVLNIVLDYVLIFGLWGFPGLGVAGAALATVISRVVGALLLLFLLLRGRLP---IKISFKGFRLDRKIIKKLLRIGLPA 235
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476636197 269 SIESVLFNGGKLLTQMFVSGMGTSVIAGNFIAFSIAALINLPGNALGSASTIITGRRLGNGQIAQAEIQLRHVFWLSTIG 348
Cdd:cd13137   236 GLEQLLRSLGFLVLLAIVASYGTAALAAYQIGLRIESLAFMPGFGFSMAASTLVGQNLGAGDPDEARRYGKRALRLGVLF 315
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476636197 349 LTAIAWLTAPFAGVMASFYTHDQDVKEVIVILIWLNAAFMPIWAASWVLPAGFKGARDARFAMWVSMLGMWGCRVVAGYT 428
Cdd:cd13137   316 MGLLGLLLFIFAPPLASLFTPDPEVIELGVLYLRIVALSQPFLAISFVLSGALRGAGDTRPPLIINLISMWLVRLPLAYL 395
                         410       420       430
                  ....*....|....*....|....*....|....*..
gi 1476636197 429 LGIVLGWGVVGVWLGMFFDWAVRAALFYWRMVTGRWL 465
Cdd:cd13137   396 LGFVLGLGLTGIWLAMFVDTIVRAILLLYRFRKGKWK 432
MATE_like_8 cd13134
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ...
29-465 6.79e-74

Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240539 [Multi-domain]  Cd Length: 438  Bit Score: 239.71  E-value: 6.79e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476636197  29 REITPLAVPIFLENTCVLLMGVLSTFLVSWLGKEAMAGVGLADSFNMVIMAFFAAIDLGTTVVVAFSLGKRDRRRARAAA 108
Cdd:cd13134     3 LSLFALAWPIFIELLLQMLLGTIDTFMLSRYSDNAVAAVGVANQILFLLILIFSFISTGTSILIAQYLGAKDKKKARQIA 82
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476636197 109 RQSLVIMTIFATVLAAVIHYFGQQIIDVvaGEATPDVKALALTYLELTVLSYPAAAIALIGSGALRGAGNTKIPLLINGG 188
Cdd:cd13134    83 GVALLFNLLLGLVFSLLLLFFGAELLRL--MGLPPELLALGSTYLRIVGGSLFLQALSLTLSAILRSHGRTKIPMYVSLI 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476636197 189 MNILNIIISSILIYGIFSWQGLGFVGAGLGLTISRYIGAIAIIWVLMIGFNPALRIpfkSYFKPLNLAIIWEVMGIGIPA 268
Cdd:cd13134   161 MNILNIVGNYLLIFGWFGLPKLGVAGVAISTVISRAVGLVLLFILLFRKLKIRFRL---KDLRPFPKKLLKKILKIGLPS 237
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476636197 269 SIESVLFNGGKLLTQMFVSGMGTSVIAGNFIAFSIAALINLPGNALGSASTIITGRRLGNGQIAQAEIQLRHVFWLSTIG 348
Cdd:cd13134   238 AGEELSYNLSQTVITAFIARLGTAALAARTYASNISMFVFLFSLAIGQATQIIVGHLVGAGDFDEAYKRVLKSLKIGLLV 317
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476636197 349 LTAIAWLTAPFAGVMASFYTHDQDVKEVIVILIWLNAAFMPIWAASWVLPAGFKGARDARFAMWVSMLGMWGCRVVAGYT 428
Cdd:cd13134   318 SLAVALLLALFREPILGLFTDDPEIIALGKTLLLISILLEPGRAFNIVLIGSLRAAGDARFPVLIGIISMWGISVPLAYL 397
                         410       420       430
                  ....*....|....*....|....*....|....*..
gi 1476636197 429 LGIVLGWGVVGVWLGMFFDWAVRAALFYWRMVTGRWL 465
Cdd:cd13134   398 LGIVLGLGLLGVWIAFAADEWVRGIIMLWRWRSGKWI 434
NorM COG0534
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];
27-458 9.85e-73

Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];


Pssm-ID: 440300 [Multi-domain]  Cd Length: 427  Bit Score: 236.19  E-value: 9.85e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476636197  27 FWREITPLAVPIFLENTCVLLMGVLSTFLVSWLGKEAMAGVGLADSFNMVIMAFFAAIDLGTTVVVAFSLGKRDRRRARA 106
Cdd:COG0534     6 ILKLLLRLALPIILGNLLQSLYGLVDTIFVGRLGTAALAAVGLAFPIFFLLIALGIGLGVGGTALVAQALGAGDREEARR 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476636197 107 AARQSLVIMTIFATVLAAVIHYFGQQIIDVVAgeATPDVKALALTYLELTVLSYPAAAIALIGSGALRGAGNTKIPLLIN 186
Cdd:COG0534    86 VLGQALLLALLLGLLLTLLGLLFAPPLLRLLG--ADPEVLALARDYLRIILLGLPFLLLFNVLNGILRGLGDTKTPMIIM 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476636197 187 GGMNILNIIISSILIYGIfswqGLGFVGAGLGLTISRYIGAIAIIWVLMIGFNPaLRIPFKSYfkPLNLAIIWEVMGIGI 266
Cdd:COG0534   164 LIGNVLNIVLDPLLIFGG----GLGVAGAALATVISQAVSALLLLYYLFRKRSL-LRLRLRDL--RPDRKILKRILRIGL 236
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476636197 267 PASIESVLFNGGKLLTQMFVSGMGTSVIAGNFIAFSIAALINLPGNALGSASTIITGRRLGNGQIAQAEIQLRHVFWLST 346
Cdd:COG0534   237 PAGLQQLAESLGFLVLNALVARLGTAAVAAYGIALRIESLAFMPALGLGQAAQPLVGQNLGAGDYDRARRAARLALLLAL 316
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476636197 347 IGLTAIAWLTAPFAGVMASFYTHDQDVKEVIVILIWLNAAFMPIWAASWVLPAGFKGARDARFAMWVSMLGMWGCRVVAG 426
Cdd:COG0534   317 GIGLLLALLLFLFPEPIIGLFTDDPEVIALAATYLRIAALFQPFDGLQFVLSGALRGAGDTRFPMIISLLRLWLVRLPLA 396
                         410       420       430
                  ....*....|....*....|....*....|..
gi 1476636197 427 YTLGIvLGWGVVGVWLGMFFDWAVRAALFYWR 458
Cdd:COG0534   397 YLLAF-LGLGLTGVWLALPIGEVLRALLLLLR 427
MATE_like_7 cd13133
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ...
28-464 4.96e-46

Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240538 [Multi-domain]  Cd Length: 438  Bit Score: 165.78  E-value: 4.96e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476636197  28 WREITPLAVPIFLENTCVLLMGVLSTFLVSWLGKEAMAGVGLADSFNMVIMAFFAAIDLGTTVVVAFSLGKRDRRRARAA 107
Cdd:cd13133     4 YREILKIALPLVLSMLSQTVMGFTDRAFLGRLSEVALAASGPAGVLYFAILMLFFGLSSGVQVFVAQYNGAGRYSRIGRV 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476636197 108 ARQSLVIMTIFATVLAAVIHYFGQQIIDVVAGEatPDVKALALTYLELTVLSYPAAAIALIGSGALRGAGNTKIPLLING 187
Cdd:cd13133    84 LWQGLYFSLLLAPLLALLSALAAPLLFLLLGHS--PEVQALEVEYFRIRILGAPFSLLGAALRAFFSGIGRTRVVMVANL 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476636197 188 GMNILNIIISSILIYGIFSWQGLGFVGAGLGLTISRYIGAIAIIWVLMIGFNPAlRIPFKSYFKPlNLAIIWEVMGIGIP 267
Cdd:cd13133   162 VMVVVNIVLDYALIFGKLGFPAMGIAGAAIATVIAEAVSLLFFLLLLFRRKNRR-RFGLRRAWRF-DRELLRRILRLGLP 239
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476636197 268 ASIESVLFNGGKLLTQMFVSGMGTSVIAGNFIAFSIAALINLPGNALGSASTIITGRRLGNGQIAQAEIQLRHVFWLSTI 347
Cdd:cd13133   240 SGLQFFLDVGAFTVFFLLIGRLGTTELAATNIVFSINSLAFLPMIGLGIAVSSLVGQALGAGRPDLAMRVTRRGLKLALA 319
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476636197 348 GLTAIAWLTAPFAGVMASFYTHDQDVKEVI---VILIWLNAAFMPIWAASWVLPAGFKGARDARFAMWVSMLGMWGCrVV 424
Cdd:cd13133   320 YMLLLGILFLLFPELLLSIFTPGADFALIAelaVPLLRFVAAYILFDALALVFAGALRGAGDTRFVMLAELIVAWLY-LL 398
                         410       420       430       440
                  ....*....|....*....|....*....|....*....|
gi 1476636197 425 AGYTLGIVLGWGVVGVWLGMFFDWAVRAALFYWRMVTGRW 464
Cdd:cd13133   399 PPAYLLVVLGAGLAGAWTVETVYVIVLALIFLLRFRSGKW 438
MATE_like_12 cd13142
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ...
23-445 4.44e-45

Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240547 [Multi-domain]  Cd Length: 444  Bit Score: 163.52  E-value: 4.44e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476636197  23 YKVLFWreitpLAVPIFLENTCVLLMGVLSTFLVSWLGKEAMAGVGLADSFNMVIMAFFAAIDLGTTVVVAFSLGKRDRR 102
Cdd:cd13142    10 LRTLLK-----LAWPIIVSNLLQVAYNLADTFWLGRLGADAVAAPSISWPLIFLFISLGGGLTVAGTALVAQYTGAGDYD 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476636197 103 RARAAARQSLVIMTIFATVLAAVIHYFGQQIIDVVAGeATPDVKALALTYLELTVLSYPAAAIALIGSGALRGAGNTKIP 182
Cdd:cd13142    85 KANKVAGQTFSFVIILSLILAVLGYILSRPLLLLLIG-APEEVYPLALAYLRIIFLGLPFMFIFFVFNSLLRGIGDTKTP 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476636197 183 LLINGGMNILNIIISSILIYGIFSWQGLGFVGAGLGLTISRYIGAIAIIWVLMIGFnPALRIPFKSyFKPlNLAIIWEVM 262
Cdd:cd13142   164 MKIMFGSVLLNVILDPLLIFGIGPFPGLGVAGAALATVISRGIAAVIGLYLLFKGR-VGLKISLRD-LKP-DWEWLKKIF 240
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476636197 263 GIGIPASIESVLFNGGKLLTQMFVSGMGTSVIAGNFIAFSIAALINLPGNALGSASTIITGRRLGNGQIAQAEIQLRHVF 342
Cdd:cd13142   241 RIGLPSSIEQSARALGFTVMTALVAGFGTVVVAAYGIGNRIISLVFLPAFGLARATSTMVGQNLGAGQIDRAEEIVKKAA 320
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476636197 343 WLSTIGLTAIAWLTAPFAGVMASFYTHDQDVKEVIVILIWLNAAFMPIWAASWVLPAGFKGARDARFAMWVSMLGMWGCR 422
Cdd:cd13142   321 LLIFLILVIGGVLAFLFAEPIVRVFINDPEVIKEGADFLRIVAPSFPFFGLFQVINGAFRGSGHTLTAMIISILRLWVIR 400
                         410       420
                  ....*....|....*....|...
gi 1476636197 423 VVAGYTLGIVLGWGVVGVWLGMF 445
Cdd:cd13142   401 IPLAYLLAYVLGLGVTGIWIAMA 423
MATE_yoeA_like cd13138
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ...
28-464 5.17e-45

Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240543 [Multi-domain]  Cd Length: 431  Bit Score: 163.01  E-value: 5.17e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476636197  28 WREITPLAVPIFLENTCVLLMGVLSTFLVS-WLGKEAMAGVGLADSFNMVIMAFFAAIDLGTTVVVAFSLGKRDRRRARA 106
Cdd:cd13138     2 LKTLLLFALPLLLSNLLQQLYNLVDLLIVGqFLGVAALAAVSNGSPIIFLLTAIGMGLSMGGTILISQYIGAKDEEKAKK 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476636197 107 AARQSLVIMTIFATVLAAVIHYFGQQIIDVVAgeATPDVKALALTYLELTVLSYPAAAIALIGSGALRGAGNTKIPLLIN 186
Cdd:cd13138    82 AVGTLLVLFLILGIVLTILGLLFAPPILRLMN--TPAEILELAVSYLRICFLGIPFIFGYNAYSAILRGLGDSKTPLYFV 159
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476636197 187 GGMNILNIIISSILIYGIfswqGLGFVGAGLGLTISRYIGAIAIIWVLMIGFNPaLRIPFKSYfkPLNLAIIWEVMGIGI 266
Cdd:cd13138   160 IIACVLNIILDLLFIAVF----HMGVAGAALATVIAQAISVLLALYYLRKKKLP-FKLSLKDF--RFDKEILKEILKIGL 232
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476636197 267 PASIESVLFNGGKLLTQMFVSGMGTSVIAGNFIAFSIAALINLPGNALGSASTIITGRRLGNGQIAQAEIQLRHVFWLST 346
Cdd:cd13138   233 PSALQQSLVSISFLIINSIVNSYGVVASAAYGIANKINSFAFLPPSAIGQAVSTFVAQNIGAGKIERAKKGLRTGIIISL 312
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476636197 347 IGLTAIAWLTAPFAGVMASFYTHDQDVKEVIVILIWLNAAFMPIWAASWVLPAGFKGARDARFAMWVSMLGMWGCRVVAG 426
Cdd:cd13138   313 IIGLIIILLVFFFAPQLLGLFTSDPEVIEIGAEYLRIYSIDYILFGILFVFNGLFRGLGKTKFPMIISILRLWLVRIPLA 392
                         410       420       430
                  ....*....|....*....|....*....|....*...
gi 1476636197 427 YTLGIVLGWGVVGVWLGMFFDWAVRAALFYWRMVTGRW 464
Cdd:cd13138   393 YLLSRLTGLGLFGIWLAMPISNILSAIICIIYYRKGRW 430
matE TIGR00797
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A. ...
37-383 8.53e-33

putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A.66) The MATE family consists of probable efflux proteins including a functionally characterized multi drug efflux system from Vibrio parahaemolyticus, a putative ethionine resistance protein of Saccharomyces cerevisiae, and the functionally uncharacterized DNA damage-inducible protein F (DinF) of E. coli. These proteins have 12 probable TMS. [Transport and binding proteins, Other]


Pssm-ID: 273273 [Multi-domain]  Cd Length: 342  Bit Score: 127.36  E-value: 8.53e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476636197  37 PIFLENTCVLLMGVLSTFLVSWLGKEAMAGVGLADSFNMVIMAFFAAIDLGTTVVVAFSLGKRDRRRARAAARQSLVIMT 116
Cdd:TIGR00797   1 PAILANILQPLLGLVDTAFVGHLGPVDLAAVSLGSSVFMFLFSILMGLGTATTALVAQAVGAGNYQRLGRQAQQSLLLAL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476636197 117 IFATVLAAVIHYFGQQIIDvvAGEATPDVKALALTYLELTVLSYPAAAIALIGSGALRGAGNTKIPLLINGGMNILNIII 196
Cdd:TIGR00797  81 LLGLPVLLVGYFFIDPLLS--LMGADGEVAELAQDYLRILILGIPAYLLNFVLRGFLRGQGDTKTPMYITLIGNVINIIL 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476636197 197 SSILIYGIFSWqgLGFVGAGLGLTISRYIGAIAIIWVLMIGfnPALRIPFKSYFKPlNLAIIWEVMGIGIPASIESVLFN 276
Cdd:TIGR00797 159 NYILIFGKFGF--LGIVGAALATVISYWLMFLLLLYYIKKA--KKIGLKWEGLLKP-DWEVLKRLLKLGLPIAFRVILES 233
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476636197 277 GGKLLTQMFVSGMGTSVIAGNFIAFSIAALINLPGNALGSASTIITGRRLGNGQIAQAEIQLRHVFWLSTIGLTAIAWLT 356
Cdd:TIGR00797 234 LSFALLALLVARLGSIALAAHQIALNVESLLFMPAFGFGIAVSILVGQALGAGDPKRAKEVARVALKLSLLLGLVLAIIL 313
                         330       340
                  ....*....|....*....|....*..
gi 1476636197 357 APFAGVMASFYTHDQDVKEVIVILIWL 383
Cdd:TIGR00797 314 ILFREFIARLFTNDPEVLELAAIYLIF 340
MATE_NorM_like cd13131
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio ...
28-460 2.90e-32

Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Vibrio cholerae NorM and functions most likely as a multidrug efflux pump, removing xenobiotics from the interior of the cell. The pump utilizes a cation gradient across the membrane to facilitate the export process. NorM appears to bind monovalent cations in an outward-facing conformation and may subsequently cycle through an inward-facing and outward-facing conformation to capture and release its substrate.


Pssm-ID: 240536 [Multi-domain]  Cd Length: 435  Bit Score: 128.00  E-value: 2.90e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476636197  28 WREITPLAVPIFLENTCVLLMGVLSTFLVSWLGKEAMAGVGLADSFNMVIMAFFAAIDLGTTVVVAFSLGKRDRRRARAA 107
Cdd:cd13131     2 LRALLRLALPILIAQLAQMAMGFVDTVMAGRLGADDLAAVALGSSLWFPVFTFGMGLLLAVTPLVAQAHGAGDRRRIRRA 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476636197 108 ARQSLVIMTIFATVLAAVI-------HYFGQqiidvvageaTPDVKALALTYLELTVLSYPAAAIALIGSGALRGAGNTK 180
Cdd:cd13131    82 VRQGLWLALLLSLPLMLLLwlappilPLMGQ----------EPEVAAIARGYLLALAWGIPPALLFQVLRSFLDALGRTR 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476636197 181 IPLLINGGMNILNIIISSILIYGIFSWQGLGFVGAGLGLTISRYIGAIAIIWVLmigfnpALRIPFKSY-----FKPLNL 255
Cdd:cd13131   152 PAMVITLLALVLNIPLNYVLIFGKFGLPALGGAGAGLATAIVYWLMFLALAFYI------RRHKRFRRYrlfarFWRPDW 225
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476636197 256 AIIWEVMGIGIPASI----ESVLFNGGKLLtqmfVSGMGTSVIAGNFIAFSIAALINLPGNALGSASTIITGRRLGNGQI 331
Cdd:cd13131   226 ARLKELLRLGLPIGLtiffEVSLFAAVALL----MGRLGTTVLAAHQIALNFASLLFMVPLGISMAATVRVGFALGAGDP 301
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476636197 332 AQAEIQLRHVFWLSTIGLTAIAWLTAPFAGVMASFYTHDQDVKEVIVILIWLNAAFMPIWAASWVLPAGFKGARDARFAM 411
Cdd:cd13131   302 ADARRAGLVGLGLGVGFAALTALLLLLFPEQIAGLYTNDPAVIALAASLLVFAALFQLFDGIQVVAAGALRGYKDTRVPF 381
                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*....
gi 1476636197 412 WVSMLGMWGCRVVAGYTLGIVLGWGVVGVWLGMFFDWAVRAALFYWRMV 460
Cdd:cd13131   382 LLALISYWGIGLPLGYLLAFTTGLGAFGVWIGLIIGLALAAILLLWRFR 430
MATE_like cd12082
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane ...
35-455 1.78e-31

Multidrug and toxic compound extrusion family and similar proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240527 [Multi-domain]  Cd Length: 420  Bit Score: 125.51  E-value: 1.78e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476636197  35 AVPIFLENTCVLLMGVLSTFLVSWLGKEAMAGVGLADSFNMVIMAFFAAIDLGTTVVVAFSLGKRDRRRARAAARQSLVI 114
Cdd:cd12082     1 AAPLLLSMLLQTLYNLVDTFFLGRLLGDALAAVGLAFPLIALLIALGVGLSVGTSALISQAIGAGDEEKARRVLVQSIVL 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476636197 115 MTIFATVLAAVIHYFGQQIIDvvAGEATPDVKALALTYLELTVLSYPAAAIALIGSGALRGAGNTKIPLLINGGMNILNI 194
Cdd:cd12082    81 AILLGLLLAALLLFFSPLILS--LLGAEEEVIELAATYLTILILGLPITFLGAVLSGILQGEGDTRTAMIISVLSNLLNI 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476636197 195 IISSILIYGIFSWqGLGFVGAGLGLTISRYIGAIAIIWVLmigFNPALRIPFKSYFKPLNLAIIWEVMGIGIPASIESVL 274
Cdd:cd12082   159 LLDPLLIFGLGPP-ELGIAGAALATVISYVIGALLLLIYL---RKGKKILKFKLSLLKPDLELLRRLLRIGLPSAIQNSL 234
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476636197 275 FNGGKLLTQMFVSG-MGTSVIAGNFIAFSIAALINLPGNALGSASTIITGRRLGNGQIAQAEIQLRHVFWLSTIGLTAIA 353
Cdd:cd12082   235 LSLGLLIIVAIVAAfGGAAALAAYTVAFRIASLAFMPALGLAQAALPVVGQNLGAGNFDRARRITWVALLIGLLIGAVLG 314
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476636197 354 WLTAPFAGVMASFYTHDQDVKEVIVILIWLNAAFMPIWAASWVLPAGFKGARDARFAMWVSMLGMWGCRVVAGYTLGiVL 433
Cdd:cd12082   315 LLILLFPEPILSLFTNDPEFLELAVSYLRILAIYYLFVGIGYVLQAGFQAAGRTLKSLIVSLLSYWVVRLPLAYVLA-YL 393
                         410       420
                  ....*....|....*....|..
gi 1476636197 434 GWGVVGVWLGMFFDWAVRAALF 455
Cdd:cd12082   394 GLGLYGIWLALVISLILAALVL 415
MATE_like_14 cd13139
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ...
29-464 9.12e-28

Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240544 [Multi-domain]  Cd Length: 448  Bit Score: 115.40  E-value: 9.12e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476636197  29 REITPLAVPIFLENTCVLLMGVLSTFLVSWLGKEAMAGVGLADSFNMVIMAFFAAIDLGTTVVVAFSLGKRDRRRARAAA 108
Cdd:cd13139    14 RAIFLLAIPMVLEMVMESLFAVVDLYFVSRLGALAIATVGLTESVLTIVYSIAIGLSMAATALVARRIGEKDPEGAGFAA 93
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476636197 109 RQSLVIMTIFATVLAAVIHYFGQQIIDVVAGEatPDVKALALTYLELTVLSYPAAAIALIGSGALRGAGNTKIPL----L 184
Cdd:cd13139    94 VQAILLGVALSLILSILGYFFAEDILSLMGAS--PAVIAEGYGYTRIMFGGNGFIMLLFLINGIFRGAGDAAIAMrslwL 171
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476636197 185 INGgmniLNIIISSILIYGIFSWQGLGFVGAGLGLTISRYIGAIAIIWVLMIGfnpALRIPFKSYFKPLNLAIIWEVMGI 264
Cdd:cd13139   172 ANG----LNIILDPLFIFGLGPIPAMGVTGAAIATTIGRSIGVLYQLYHLFKG---KGRIQIRRRHLKLDWAIIKKIIKI 244
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476636197 265 GIPASIESVLFNGGKLLTQMFVSGMGTSVIAGNFIAFSIAALINLPGNALGSASTIITGRRLGNGQIAQAEIQLRHVFWL 344
Cdd:cd13139   245 AVGGILQFLIASSSWIFLVRIIAEFGSTALAGYTIAIRIIMFALLPAWGLSNAAATLVGQNLGAGQPDRAEKSVWRAGKY 324
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476636197 345 STIGLTAIAWLTAPFAGVMASFYTHDQDVKEVIVILIWLNAAFMPIWAASWVLPAGFKGARDARFAMWVSMLGMWGCRVV 424
Cdd:cd13139   325 NMVFLGIVSLVFFLFAEPLVSFFTTDPEVIAIAVEALRIISLGYIFYGYGMVLSQAFNGAGDTKTPTLINLVGFWLFQIP 404
                         410       420       430       440
                  ....*....|....*....|....*....|....*....|
gi 1476636197 425 AGYTLGIVLGWGVVGVWLGMFFDWAVRAALFYWRMVTGRW 464
Cdd:cd13139   405 LAYLLARHLNLGPKGVFIAIPIAETVLAIAAIILFRRGKW 444
MATE_DinF_like cd13136
DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE) ...
28-461 3.75e-25

DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli DinF is a membrane protein that has been found to protect cells against oxidative stress and bile salts. The expression of DinF is regulated as part of the SOS system. It may act by detoxifying oxidizing molecules that have the potential to damage DNA. Some member of this family have been reported to enhance the virulence of plant pathogenic bacteria by enhancing their ability to grow in the presence of toxic compounds. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).


Pssm-ID: 240541 [Multi-domain]  Cd Length: 424  Bit Score: 107.26  E-value: 3.75e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476636197  28 WREITPLAVPIFLENTCVLLMGVLSTFLVSWLGKEA-MAGVGLADSFNMVIMAFFAAIDLGTTVVVAFSLGKRDRRRARA 106
Cdd:cd13136     2 HREILALALPAILSNITVPLLGLVDTAVVGHLGSAAyLGAVALGTTIFNTLFWLFGFLRMGTTGLVAQALGAGDREEAIA 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476636197 107 AARQSLVIMTIFATVLAAvihyFGQQIID--VVAGEATPDVKALALTYLELTVLSYPAAAIALIGSGALRGAGNTKIPLL 184
Cdd:cd13136    82 LLVRALLLALAIGLLLIL----LQSPLLAlaLLLLGASAAVAALARQYLRIRILGAPAVLLNYVATGWFRGLQDTRTPLI 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476636197 185 INGGMNILNIIISSILIYGIfswqGLGFVGAGLGLTISRYIGAIAIIWVLMIGFNPALRIPFKSYFKPLNLAIIwevMGI 264
Cdd:cd13136   158 LQIVGNVVNIVLDPLFVFGL----GWGVAGAALATVIAQYLGALLGLWLLRRRVRLLGKSLSRRLPSKAALKRL---FKL 230
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476636197 265 GIPASIESVLFNGGKLLTQMFVSGMGTSVIAGNFIAFSIAALINLPGNALGSASTIITGRRLGNGQIAQAEIQLRHVF-- 342
Cdd:cd13136   231 NRDIFIRTLALLAAFLFFTALAARLGDVILAANQILLQFWLLSSYFLDGFAYAAEALVGRALGAGDRKAARRVARRLLqw 310
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476636197 343 -WLSTIGLTAIAWLtapFAGVMASFYTHDQDVKEVIVILIWLNAAFMPIWAASWVLPAGFKGARDARFAMWVSMLGmwgc 421
Cdd:cd13136   311 gLGLGVLLALLFFL---GGEPIIRLFTDDPAVLALAATYLPWLALLPPIGALAFVLDGIFIGATDTRYLRNSMLVS---- 383
                         410       420       430       440
                  ....*....|....*....|....*....|....*....|...
gi 1476636197 422 rvVAGYTLGIVL---GWGVVGVWLGMFFDWAVRAALFYWRMVT 461
Cdd:cd13136   384 --LAVFLPLLFLlvpLWGNHGLWLALILFMLLRGLTLALRLPR 424
MatE pfam01554
MatE; The MatE domain
37-187 1.40e-21

MatE; The MatE domain


Pssm-ID: 334587 [Multi-domain]  Cd Length: 161  Bit Score: 91.09  E-value: 1.40e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476636197  37 PIFLENTCVLLMGVLSTFLVSWLGKEAMAGVGLADSFNMVIMAFFAAIDLGTTVVVAFSLGKRDRRRARAAARQSLVIMT 116
Cdd:pfam01554   1 PIALENLLQSLYSLIDTLFVGHLGAVALAAVSIANSIASLIFMFLLGLGTALTTLVGQALGAGNFKRAGVALRQGLILGL 80
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1476636197 117 IFATVLAAVIHYFGQQIIDVVAGEatPDVKALALTYLELTVLSYPAAAIALIGSGALRGAGNTKIPLLING 187
Cdd:pfam01554  81 LLSLPIALLVLLFSEPILSLFGQD--EEVLALAKRYLRILILGIPFYALQFVLSGFLRGQGDTKPPMYINI 149
MATE_like_9 cd13135
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ...
29-458 8.23e-21

Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240540 [Multi-domain]  Cd Length: 429  Bit Score: 94.67  E-value: 8.23e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476636197  29 REITPLAVPIFLENTCVLLMGVLSTFLVSWLGKEAMAGVGLADSFNMVIMAFFAAIDLGTTVVVAFSLGKRDRRRARAAA 108
Cdd:cd13135     1 KKINHIAIPLILQNLVSQLQMLVDRAFLGRISIRYYSAVGNVTTPFNTITGFLGSISIGFTILGSQSVGAKDIKRINDYA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476636197 109 RQSLVIMTIFAtVLAAVIHYFGQQIIDVVAGeATPDVKALALTYLELTVLSYPAAAIALIGSGALRGAGNTKiPLLINGG 188
Cdd:cd13135    81 ISSIVYNSIIG-VILFLLWLFGARIIFVLFG-VDGQILGYSINYVRIFSIYLLLLGILFTFSSILQGIGETK-PIMYGGI 157
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476636197 189 MNILN-IIISSILIYGIFSWQGLGFVGAGLGLTISRYIGAIAIIWVLM----IGFNPALRIPFKSYFKPLNLAIiwevmG 263
Cdd:cd13135   158 IKNLLnVILDYVLIFGNFGFPRLGIIGAAIATTIANVLNLIILVYLCRkikkLTFKLSNTKVLKANIRPYKFTI-----K 232
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476636197 264 IGIPASIESVLFNGGKLLTQMFVSGMGTSVIAGNFIAFSIAALINLPGNALGSASTIITGRRLGNGQIAQAEIQLRHVFW 343
Cdd:cd13135   233 LGLPLGGEEFLWNIGNLAVIRILNRIGELALGIYTLVFGIENIVLMPMYGYSSAALTLVGESIGKKDLKEALRIGNICLG 312
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476636197 344 LSTIGLTAIAWLTAPFAGVMASFYTHDQDVKEVIVILIWLNAAFMPIWAASWVLPAGFKGARDARFaMWVSMLGMWGCRV 423
Cdd:cd13135   313 LGLLIYIAAAIVFLAFPYKILSLFTNDPELINYSIPYLIFIIIILFFKSINIVYGFAIRAIGDTKW-MLYTQIIGTIIVV 391
                         410       420       430
                  ....*....|....*....|....*....|....*
gi 1476636197 424 VAGYTLGIVLGWGVVGVWLGMFFDWAVRAALFYWR 458
Cdd:cd13135   392 SVALLLIFVFKLGLAGVYITLFIDEIIRAIINFLK 426
MATE_MJ0709_like cd13147
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins, ...
34-444 1.78e-19

Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins, similar to Methanocaldococcus jannaschii MJ0709; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240552 [Multi-domain]  Cd Length: 441  Bit Score: 90.68  E-value: 1.78e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476636197  34 LAVPIFLENTCVLLMGVLSTFLVSWLGKEAMAGVGLADSFNMVIMAFFAAIDLGTTVVVAFSLGKRDRRRARAAARQSLV 113
Cdd:cd13147    14 LSIPMIIAMLLQTLYNLVDAIWVAGLGADALAAIGFVFPLFMIIIGLGNGLGAGASSAISRRIGAKDKEGADNAAVHSIL 93
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476636197 114 IMTIFATVLAAVIHYFGQQIIDVVAGEatpDVKALALTYLELTVLSYPAAAIALIGSGALRGAGNTKIPLLINGGMNILN 193
Cdd:cd13147    94 LGLIISIILTIVLLPFLEPILVLMGAG---EVLDLAVDYGRIIFLGSIFLIFNNVAYGILRGEGDTKRAMYAMVAGSILN 170
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476636197 194 IIISSILIYGIfswqGLGFVGAGLGLTISRYIGAIAIIWVLMIGFNPALRIPFKsYFKPlNLAIIWEVMGIGIPASIE-- 271
Cdd:cd13147   171 IILDPIFIYTL----GLGIAGAAWATVISMLISSLVLLYWFFVKKDTYVSLSLK-NFKF-DKKIVKDILKVGIPASLEql 244
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476636197 272 --SVLFnggKLLTQMFVSGMGTSVIAGNFIAFSIAALINLPGNALGSASTIITGRRLGNGQIAQAEIQLRHVFWLSTIGL 349
Cdd:cd13147   245 imSVLM---IILNLILVIVAGTDGVAVYTAGWRIVSFAIIPLIGIATAVTSVTGAAYGARNYEKLKTAYNYSIKLGLIIE 321
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476636197 350 TAIAWLTAPFAGVMASFYTHDQDVKEVIVILI-WLNAA--FMPIWAASWVLPAGFKGARDARFAMWVSMLGMWGCRVVAG 426
Cdd:cd13147   322 LIIAILIFIFAPQIAYLFTYSEESAHLAPEIVaFLRIMclFLPFVPFGMMSSSMFQGIGKGLTSLIITILRELIFQVLFA 401
                         410
                  ....*....|....*...
gi 1476636197 427 YTLGIVLGWGVVGVWLGM 444
Cdd:cd13147   402 YLFAIVLGLGLFGVWWGI 419
MATE_like_2 cd13149
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ...
28-382 1.67e-18

Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240554 [Multi-domain]  Cd Length: 434  Bit Score: 87.74  E-value: 1.67e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476636197  28 WREITPLAVPIFLENTCVLLMGVLSTFLVSWLGKEAMAGVGLADSFNMVIMAFFAAIDLGTTVVVAFSLGKRDRRRARAA 107
Cdd:cd13149     8 PRHLIKLTLPMIFGILAMLIFNLTDTFFVGKLGTKELAAISFTFPVVLFLNSLTIGLGIGASAVISRAIGAGDRNKAKRL 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476636197 108 ARQSLVIMTIFATVLAAVIHYFGQQIIDVVAgeATPDVKALALTYLELTVLSYPAAAIALIGSGALRGAGNTKIPLLING 187
Cdd:cd13149    88 ATDSLILSLLLSVIVSLLGLFTIPPLFSLLG--ASGEILPLIVEYMAIWYLGLVFLVLPMVGNAIIRATGDTKRPSLVML 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476636197 188 GMNILNIIISSILIYGIFSWQGLGFVGAGLGLTISRYIGAIAIIWVLMigFNPALRIPFKSYFKPLNLAIIwEVMGIGIP 267
Cdd:cd13149   166 GAALVNVILDPILIFGFGPIPGMGIAGAAIATVISRALGLGAALYFLH--YHHRLIDFSEPSLKALFRSWK-DILSIGIP 242
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476636197 268 ASIESVLFNGGKLLTQMFVSGMGTSVIAGNFIAFSIAALINLPGNALGSASTIITGRRLGNGQIAQAEIQLRHVFWLSTI 347
Cdd:cd13149   243 AALSNILTPLSAAFITALVATYGPAAVAAFGVATRIESFAFIIVMALSSALGPFVGQNWGAGQYERVQEGLKISLKFSLI 322
                         330       340       350
                  ....*....|....*....|....*....|....*
gi 1476636197 348 GLTAIAWLTAPFAGVMASFYTHDQDVKEVIVILIW 382
Cdd:cd13149   323 YGAILGIVLALFAGWLASLFSAEPEVIELITLYLL 357
MATE_MepA_like cd13143
Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to ...
26-444 1.44e-17

Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. This subfamily includes Streptococcus aureus MepA and Vibrio vulnificus VmrA and functions most likely as a multidrug efflux pump.


Pssm-ID: 240548 [Multi-domain]  Cd Length: 426  Bit Score: 84.48  E-value: 1.44e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476636197  26 LFWReitpLAVPIFLENTCVLLMGVLSTFLVS-WLGKEAMAGVGLADSFNMVIMAFFAAIDLGTTVVVAFSLGKRDRRRA 104
Cdd:cd13143     5 LFLK----FALPAIIGMLVNGLYNIVDGIFVGhGVGALALAAVNLVFPIIMLLMALGLMIGVGGASLISRRLGAGDREKA 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476636197 105 RAAARQSLVIMTIFATVLAAVIHYFGQQIIDVVAgeATPDVKALALTYLELTVLSYPAAAIALIGSGALRGAGNTKIPLL 184
Cdd:cd13143    81 NRIFSTALLLSLILGLLLTILGLLFLDPLLRLLG--ASGELLPYAVDYLRIILLGAPFTILSSVLNNLLRAEGKPKLAML 158
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476636197 185 ingGMNILNIIISSILIYGIFSWqGLGFVGAGLGLTISRYIGAIAIIWVLMIGfnpALRIPFKSYFKPLNLAIIWEVMGI 264
Cdd:cd13143   159 ---GMLIGAVLNIILDPLFIFVL-GLGIAGAALATVIAQLISLLLLLLYFFRG---KSLLKLSLLRFKLSLKIIKEILAL 231
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476636197 265 GIPASIESVLFN-GGKLLTQMFVSGMGTSVIAGNFIAFSIAALINLPGNALGSASTIITGRRLGNGQIAQAEIQLRHVFW 343
Cdd:cd13143   232 GFPSFLMQLSSSvVTIVLNLTLLGYGGDIGVAAFGIVTRILTFLFLPLIGLSQGLQPIIGYNYGAGNYDRVKQALKLALI 311
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476636197 344 LSTIGLTAIAWLTAPFAGVMASFYTHDQDV-KEVIVILIWLNAAFmPIWAASWVLPAGFKGARDARFAMWVSMLGMWGCR 422
Cdd:cd13143   312 VALIYGLVLFLILLLFPEQIVSLFTDDPELiALAARILRIFLLAF-PLAGINIVLSGYFQAIGKAKRAALLSLLRQGLFL 390
                         410       420
                  ....*....|....*....|..
gi 1476636197 423 VVAGYTLGIVlgWGVVGVWLGM 444
Cdd:cd13143   391 IPLLLILPRL--FGLDGIWLAF 410
MATE_like_5 cd13145
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ...
34-457 2.33e-16

Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240550 [Multi-domain]  Cd Length: 440  Bit Score: 81.10  E-value: 2.33e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476636197  34 LAVPI---FLENTcvlLMGVLSTFLVSWLGKEAMAGVGLADSFNMVIMAFFAAIDLGTTVVVAFSLGKRDRRRARAAARQ 110
Cdd:cd13145    14 LAIPAsvgFFFNT---MFNVVDTFFAGKISTEALAALSLSFPIFFIIIAIGVGIGTGTTALIGNALGAGDRRKARRYAAQ 90
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476636197 111 SLVIMTIFATVLAAVIHYFGQQIIDVVAgeATPDVKALALTYLELTVLSYPAAAIALIGSGALRGAGNTK-------IPL 183
Cdd:cd13145    91 GLSFGIILAILLTVIGLFAAPPLFRLLG--AEGDYLDLALEYMDVIFAGSIFFLLNFGLNGILNAQGDTKsyrnfliIGF 168
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476636197 184 LINggmnilnIIISSILIYGIFSWQGLGFVGAGLGLTISRYIGAIAIIWVLMIGFNPALRIPfkSYFKPlNLAIIWEVMG 263
Cdd:cd13145   169 FLN-------IILDPLFIFGGGGIPAMGVSGIALATIISQFIGMFYLLYKVRKSGIISGCRL--RDFIP-RLDVYKEILK 238
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476636197 264 IGIPASIESVLFNGGKLLTQMFVSGMGTSVIAGNFIAFSIAALINLPGNALGSASTIITGRRLGNGQ---IAQAEIQ-LR 339
Cdd:cd13145   239 QGFPASLNMMTIGLGIFVITYFVGQFGDEAVAAYGIALRIEQILLLPTIGLNTAVLSIAGQNFGAKKydrVRETYKKaLK 318
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476636197 340 HVFWLSTIGlTAIAWLTAPFAgvmASFYTHDQDVKEVIVILIWLNAAFMPIWAASWVLPAGFKGARDARFAMWVSMLgmw 419
Cdd:cd13145   319 YGFVIMVVA-TVFLLFFAEPL---MSLFTNDPAVIAIGAGYLRIDALIFYAYVVLFISVSVLQGLKRPIFALWIGLY--- 391
                         410       420       430       440
                  ....*....|....*....|....*....|....*....|...
gi 1476636197 420 gcRVVAG-----YTLGIVLGWGVVGVWLGMFFDWAVRAALFYW 457
Cdd:cd13145   392 --RQLVGpalvfWLLVNVLGLGVTGIWWGIFTIVWSAAIIALL 432
MATE_like_1 cd13140
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ...
53-444 5.63e-16

Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240545 [Multi-domain]  Cd Length: 435  Bit Score: 79.88  E-value: 5.63e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476636197  53 TFLVSWLGKEAMAGVGLADSFNMVIMAFFAAIDLGTTVVVAFSLGKRDRRRARAAARQSLVIMTIFATVLAAVIHYFGQQ 132
Cdd:cd13140    29 MFWVGRLGSDAVAAVGTAGFFVWLAYALALLSKIGAQVKVSQSIGAKDEKEARKYARNALQLNLLLGILYGLLLLLFAKP 108
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476636197 133 IIDVVAGEAtPDVKALALTYLELTVLSYPAAAIALIGSGALRGAGNTKIPLLINGGMNILNIIISSILIYGIFSWQGLGF 212
Cdd:cd13140   109 LIGFFNLGD-AEVISLAITYLRIVALGLIFSFLNPVFTGIFNALGDSKTPFIINAIGLVLNIILDPLLIFGFGPFPALGV 187
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476636197 213 VGAGLGLTISRYIGAIAIIWVLMIGFNPALRIPFksyFKPLNLAIIWEVMGIGIPASIESVLFNGGKLLTQMFVSGMGTS 292
Cdd:cd13140   188 AGAALATVLAQAIVFLLFLYALKKKKGLFLKIRI---LKRPDRKYIKEILKLGLPVALQSILFALISMILARIIASFGPV 264
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476636197 293 VIAGNFIAFSIAALINLPGNALGSASTIITGRRLGNGQIAQAEIQLRHVFWLSTIGLTAIAWLTAPFAGVMASFYTHDQD 372
Cdd:cd13140   265 AIAAQKVGSQIESISWMTAEGFSTALAAFVGQNYGAGKYDRIRKGYKTALKIASAIGLFATLLLFFFGEPLFSLFIPDPE 344
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1476636197 373 VKEV-IVILIWLNAA--FMPIWAASwvlpAG-FKGARDARFAMWVSMLGMwGCRVVAGYTLGIvLGWGVVGVWLGM 444
Cdd:cd13140   345 TIAIgVDYLRILGFSqlFMCLEITT----TGaFNGLGRTKPPAIISIVFN-GLRIPLALLLSP-TGLGLNGIWWAI 414
PRK01766 PRK01766
multidrug efflux protein; Reviewed
28-469 2.91e-15

multidrug efflux protein; Reviewed


Pssm-ID: 234981 [Multi-domain]  Cd Length: 456  Bit Score: 77.93  E-value: 2.91e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476636197  28 WREITPLAVPIFLENTCVLLMGVLSTFLVSWLGKEAMAGVGLADSFNMVIMAFFAAIDLGTTVVVAFSLGKRDRRRARAA 107
Cdd:PRK01766   11 ARQLLALALPILLAQVAQTAMGFVDTVMAGGVSATDLAAVAIGTSIWLPVILFGHGLLLALTPIVAQLNGAGRRERIAHQ 90
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476636197 108 ARQSLVIMTIFATVLAAVIhYFGQQIIDVVAGeATPDVKALALTYLELTVLsypaAAIALIGSGALR----GAGNTKIPL 183
Cdd:PRK01766   91 VRQGLWLALFLSVLIMLVL-YNAVPPILNMMN-LEPEVADIAVGYLHALLW----GIPAYLLYQVLRsfidGLGKTKPTM 164
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476636197 184 LINGGMNILNIIISSILIYGIFSWQGLGFVGAGLGLTISRYIGAIAIIWVLMIGFNPALRIPFKSYFKPlNLAIIWEVMG 263
Cdd:PRK01766  165 VIGFLGLLINIPLNYIFIYGKFGFPELGGVGCGVATAIVYWVMFLAMLIYIKRARRFRDFRLFKGLYKP-DWAVIKRLLK 243
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476636197 264 IGIPASIeSVLFNGGKL-LTQMFVSGMGTSVIAGNFIAFSIAALINLPGNALGSASTIITGRRLGNGQIAQAEiQLRHVF 342
Cdd:PRK01766  244 LGLPIGL-AIFFEVSLFaVVTLLVSPLGTVTVAAHQIALNFSSLLFMLPLSLAMALTIRVGFELGAGRTLDAR-QYAYIG 321
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476636197 343 WLSTIGLTAI-AWLTAPFAGVMASFYTHDQDVKEVIVILIwLNAAFMPIWAASWVLPAG-FKGARDARFAMWVSMLGMWG 420
Cdd:PRK01766  322 LAVGLGMALLtAIFLVLFREQIALLYTDDPEVVALASHLL-LFAALFQFSDAIQVIGSGaLRGYKDTRVIFFITFIAYWV 400
                         410       420       430       440
                  ....*....|....*....|....*....|....*....|....*....
gi 1476636197 421 CRVVAGYTLGIVLGWGVVGVWLGMFFDWAVRAALFYWRMvtgRWLWKYP 469
Cdd:PRK01766  401 LGLPLGYILALTDPMGPFGFWIGLIIGLTAAAILLLLRL---RKLQRQP 446
MatE pfam01554
MatE; The MatE domain
267-418 9.27e-13

MatE; The MatE domain


Pssm-ID: 334587 [Multi-domain]  Cd Length: 161  Bit Score: 66.05  E-value: 9.27e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476636197 267 PASIESVLFNGGKLLTQMFVSGMGTSVIAGNFIAFSIAALINLPGNALGSASTIITGRRLGNGQIAQAEIQLRHVFWLST 346
Cdd:pfam01554   1 PIALENLLQSLYSLIDTLFVGHLGAVALAAVSIANSIASLIFMFLLGLGTALTTLVGQALGAGNFKRAGVALRQGLILGL 80
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1476636197 347 IGLTAIAWLTAPFAGVMASFYTHDQDVKEVIVILIWLNAAFMPIWAASWVLPAGFKGARDARFAMWVSMLGM 418
Cdd:pfam01554  81 LLSLPIALLVLLFSEPILSLFGQDEEVLALAKRYLRILILGIPFYALQFVLSGFLRGQGDTKPPMYINIISL 152
MATE_like_13 cd13141
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ...
29-376 2.96e-12

Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240546 [Multi-domain]  Cd Length: 443  Bit Score: 68.50  E-value: 2.96e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476636197  29 REITPLAVPIFLENTCVLLMGVLSTFLVSWLGKEAMAGVGLADSFNMVIMAFFAAIDLGTTVVVAFSLGKRDRRRARAAA 108
Cdd:cd13141    11 KHIISMALPIAIGMIIQTLYFLVDLYFVGQLGDAALAGVSLAGNVMFFVMALTQVLNVGTAALVSHAVGRKDQGEANAVF 90
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476636197 109 RQSLVIMTIFATVLAAVIHYFGQQIIDVVAGEATpdVKALALTYLELTVLSYPAAAIALIGSGALRGAGNTKIPLLINGG 188
Cdd:cd13141    91 NQSLLLAAVLGLVVLVLGYLFGRLYLETLAADAA--TVEAATTYLYWFIPSLALQFILTVLGAALRGTGIVKPFMVIQIL 168
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476636197 189 MNILNIIISSILIYGIFSWQGLGFVGAGLGLTISrYIGAIAIIWVLMIGFNPALRIPFKSyFKPlNLAIIWEVMGIGIPA 268
Cdd:cd13141   169 AVLLNIILAPILITGWGTGRALGVAGAGLASSIS-VAIAVVLLLYYFLRLEKYLRLDLAL-WRP-DLPTWKRLLKIGLPS 245
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476636197 269 SIESVLFNGGKLLTQMFVSGMGTSVIAGNFIAFSIAALINLPGNALGSASTIITGRRLGNGQIAQAEIQLRHVFWLSTIG 348
Cdd:cd13141   246 GGEFLLTFVYMAVIYWALRPFGAAAQAGFGIGSRIMQSLFLPAMAIAFAAPAIAGQNFGAGNYDRVRETFRITAILTTAL 325
                         330       340
                  ....*....|....*....|....*...
gi 1476636197 349 LTAIAWLTAPFAGVMASFYTHDQDVKEV 376
Cdd:cd13141   326 MLVLTLLCQLVPELLVTPFSDDAAVIAV 353
MATE_like_3 cd13148
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ...
34-335 6.02e-12

Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240553 [Multi-domain]  Cd Length: 441  Bit Score: 67.30  E-value: 6.02e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476636197  34 LAVP---IFLENTCVllmGVLSTFLVSWLGKEAMAGVGLADSFNMVI-MAFFAAIDLGTTVVVAFSLGKRDRRRARAAAR 109
Cdd:cd13148    17 LALPnilALLVQTLV---GLAETYFVGQLGTDALAGVALVFPLLMLTqMMSNGAMGGGVSSAIARALGAGDRERAEALVW 93
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476636197 110 QSLVIMTIFATVLAAVIHYFGQQIIDVVAGEAtpDVKALALTYLEltVLSYPAAAIALIG--SGALRGAGNTKIPLLING 187
Cdd:cd13148    94 HALVIALAGGLVFSLLFLLFGPALYRLLGGRG--EALDAALAYSN--VLFSGAILIWLVNllAAALRGTGNMRVPALVTL 169
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476636197 188 GMNILNIIISSILIYGIFSWQGLGFVGAGLGLTISRYIGAIAIIWVLMIGFNpalRIPFKSYFKPLNLAIIWEVMGIGIP 267
Cdd:cd13148   170 VGAVVQIPLSPGLILGWGPLPRLGVAGAAVAAVLYYALAALVLLRYLASGRS---RLRLRLRALRLERRLFRDILRVGLL 246
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1476636197 268 ASIESVLFNGGKLLTQMFVSGMGTSVIAGNFIAFSIAALINLPGNALGSASTIITGRRLGNGQIAQAE 335
Cdd:cd13148   247 AALSPLQTNLTVLLLTGLVGRFGTAALAGYGIGSRLEFLLIPLVFGLGAAMTAMVGMNIGAGQIARAR 314
NorM COG0534
Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];
257-471 1.50e-11

Na+-driven multidrug efflux pump, DinF/NorM/MATE family [Defense mechanisms];


Pssm-ID: 440300 [Multi-domain]  Cd Length: 427  Bit Score: 65.94  E-value: 1.50e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476636197 257 IIWEVMGIGIPASIESVLFNGGKLLTQMFVSGMGTSVIAGNFIAFSIAALINLPGNALGSASTIITGRRLGNGQIAQAEI 336
Cdd:COG0534     6 ILKLLLRLALPIILGNLLQSLYGLVDTIFVGRLGTAALAAVGLAFPIFFLLIALGIGLGVGGTALVAQALGAGDREEARR 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476636197 337 QLRHVFWLSTIGLTAIAWLTAPFAGVMASFYTHDQDVKEVIVILIWLNAAFMPIWAASWVLPAGFKGARDARFAMWVSML 416
Cdd:COG0534    86 VLGQALLLALLLGLLLTLLGLLFAPPLLRLLGADPEVLALARDYLRIILLGLPFLLLFNVLNGILRGLGDTKTPMIIMLI 165
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1476636197 417 GMwGCRVVAGYTLGIVLGWGVVGVWLGMFFDWAVRAALFYWRMVTGRWLWKYPRP 471
Cdd:COG0534   166 GN-VLNIVLDPLLIFGGGLGVAGAALATVISQAVSALLLLYYLFRKRSLLRLRLR 219
MATE_eukaryotic cd13132
Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral ...
29-446 3.19e-11

Eukaryotic members of the multidrug and toxic compound extrusion (MATE) family; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria. This subfamily, which is restricted to eukaryotes, contains vertebrate solute transporters responsible for secretion of cationic drugs across the brush border membranes, yeast proteins located in the vacuole membrane, and plant proteins involved in disease resistance and iron homeostatis under osmotic stress.


Pssm-ID: 240537 [Multi-domain]  Cd Length: 436  Bit Score: 65.29  E-value: 3.19e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476636197  29 REITPLAVPIFLENTCVLLMGVLSTFLVSWLGKEAMAGVGLADSFNMVImAFFAAIDLGTTV--VVAFSLGKRDRRRARA 106
Cdd:cd13132     3 KKLLRLAAPLVLTSLLQYSLSVVSVVFVGHLGKLELAAASLASSFANVT-GFSILLGLASALdtLCGQAFGAKNYKLVGV 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476636197 107 AARQSLVIMTIFATVLAAVI-------HYFGQqiidvvageaTPDVKALALTYLELTVLSYPAAAIALIGSGALRGAGNT 179
Cdd:cd13132    82 YLQRALVILLLCCVPISLLWlntepilLLLGQ----------DPEIARLAGEYLRWLIPGLFAYALFEPLKRYLQAQGIV 151
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476636197 180 KIPLLINGGMNILNIIISSILIYGIfswqGLGFVGAGLGLTISRYIGAIA-IIWVLMIGFNPALRIPFKSyfkpLNLAII 258
Cdd:cd13132   152 LPLVYISLVALLLNILLNYLLVFVL----GLGFIGAALATSISYWLIVVLlLLYIFFSKGHKATWGGFSR----EAFRGW 223
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476636197 259 WEVMGIGIPASI----ESVLFNGGKLLTQMFVsgmGTSVIAGNFIAFSIAALINLPGNALGSASTIITGRRLGNGQIAQA 334
Cdd:cd13132   224 GPFLKLAIPSALmlclEWWAFEILVLLAGLLP---GTVALAAQSICLTTTSLLYMIPLGISIAASVRVGNELGAGNPKRA 300
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476636197 335 EIQLRHVFWLSTIGLTAIAWLTAPFAGVMASFYTHDQDVKEVIVILIWLNAAFMPIWAASWVLPAGFKGARDARFAMWVS 414
Cdd:cd13132   301 KLAAIVALILSLVIGVVVAILLLVLRDVWAYLFTSDEEVIALVADLLPILALFQIFDGLQAVLSGVLRGCGRQKLGAYVN 380
                         410       420       430
                  ....*....|....*....|....*....|..
gi 1476636197 415 MLGMWGCRVVAGYTLGIVLGWGVVGVWLGMFF 446
Cdd:cd13132   381 LVAYYLIGLPVGLLLAFVLGLGLKGLWIGLIA 412
MATE_like_6 cd13146
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ...
34-460 8.62e-11

Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240551 [Multi-domain]  Cd Length: 433  Bit Score: 63.57  E-value: 8.62e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476636197  34 LAVPIFLENTCVLLMGVLSTFLVSWLGKEA---MAGVGLADSFNMVIMAFFAAIDLGTTVVVAFSLGKRDRRRARAAARQ 110
Cdd:cd13146    13 LALPILIGQLFQLLYNITDTIWISMIDPSDpalVGGIGLVFPLGMIFLALGNGIQVGVSSLLARAIGAQRAKELDQAADS 92
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476636197 111 SLVIMTIFATVLAAVIHYFGQQIIDVVAGEATPDVKALALTYLELTVLSYPAAAIALIgsGALRGAGNTKIpllINGGMN 190
Cdd:cd13146    93 GLALALLAATVIVVLGYIFAEPLLQLLGAKGLLLEYALEYFYYSLPGVPFIMLIGVLM--GVLQGEGRTKY---MMMAML 167
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476636197 191 ILNIIISSILIYGIFSWqGLGFVGAGLGLTISRYIGAIAIIWVLMIGfnpALRIPFKSYFKPLNLAIIWEVMGIGIPASI 270
Cdd:cd13146   168 IGTVVNIVLDPILIFVF-DMGVKGAALATVLAQAISLLYLLYVFLIG---KSNVTIHIKLSNISSSVIVEILRVGLPQML 243
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476636197 271 ESVLFNGGKLLTQMFVSGMGTSVIAGNFIAFSIAALINLPGNALGSASTIITGRRLGNGQIAQAEIQLRHVFWLSTIGLT 350
Cdd:cd13146   244 LQLISSISFLIYNRIIIDIDPVAMTAFTLVGRLDQFILIPIFAISSALLTIAGQNWGRGNYDRMLQILMTAVILGIVVVL 323
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476636197 351 AIAWLTAPFAGVMASFYTHDQDVKEVIVILIWLNAAFMPIWAASWVLPAGFKGARDARFAMWVSMLGMWGCRVVAGYTLG 430
Cdd:cd13146   324 VLVLGYVLVAPWLFSLFTTVPEVVAYAVLQVRTMALALPFVAISILVTEFFQAIGKAWPSLLLTLIRHVFLSVPVVYLLA 403
                         410       420       430
                  ....*....|....*....|....*....|
gi 1476636197 431 IVLGWGVVGVWLGMFFDwAVRAALFYWRMV 460
Cdd:cd13146   404 YVFGKGITGVYFGIVSA-NFFTALLAMFWG 432
MATE_like_4 cd13144
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ...
29-442 3.69e-05

Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240549 [Multi-domain]  Cd Length: 434  Bit Score: 46.07  E-value: 3.69e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476636197  29 REITPLAVPIFLENTCVLLMGVLSTFLVSWLGKEAMAGVGLADSFNMVIMAFFAAIDLGTTVVVAFSLGKRDRRRARAAA 108
Cdd:cd13144     8 RLLLTMSIPAMISMLFQALYNIVDSIFVARLGENALTAVSLAFPIQNLMIAVAVGTGVGVNALLSRSLGEKDQKEANKAA 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476636197 109 RQSLViMTIFATVLAAVIHYFGQQIIdVVAGEATPDVKALALTYLELTVLSYPAAAIALIGSGALRGAGNTKIPLLINGG 188
Cdd:cd13144    88 NNGLL-LALLSYLLFLLLGLFGVKPF-FRLFTDDPEILEYGYAYLSWCVIFSFGMFFQILCEKVLQSTGNTITPMIAQLI 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476636197 189 MNILNIIISSILIYGIFSWQGLGFVGAGLGLTISRYIGAIaIIWVLMIGFNPAlrIPFKSYFKPLNLAIIWEVMGIGIPA 268
Cdd:cd13144   166 GAIINIILDPILIFGLFGFPAMGIAGAAIATVIGQILAMF-LAFFFLLRKNKD--VQPDLRLFRPSLRIIKEIYAVGLPS 242
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476636197 269 SIESVLFNGGKLLTQMFVSGMGTSVIAGNFIAFSIAALINLPGNALGSASTIITGRRLGNGQIAQAEIQLRHVFWLSTIG 348
Cdd:cd13144   243 IIMQAISSVMVFGLNKILAGFGPTAVAVFGIYFKLQSFVFMPVFGLNNGLIPIVAYNYGAGNKDRIREAIKYAILIAVVI 322
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476636197 349 LTAIAWLTAPFAGVMASFYTHDQDVKEVIVILIWLNAAFMPIWAASWVLPAGFKGARDARFAMWVSMLGMWGCRVVAGYT 428
Cdd:cd13144   323 MLAGGLLFQLFPDQLLGLFNASEEMLAIGVPALRIISLSFLFAALSIILSGLFQALGRGVYSLIISVARQLVVLLPLAWL 402
                         410
                  ....*....|....
gi 1476636197 429 LGivLGWGVVGVWL 442
Cdd:cd13144   403 LA--KMFGLNGVWW 414
PRK00187 PRK00187
NorM family multidrug efflux MATE transporter;
204-482 1.22e-04

NorM family multidrug efflux MATE transporter;


Pssm-ID: 166843 [Multi-domain]  Cd Length: 464  Bit Score: 44.35  E-value: 1.22e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476636197 204 IFSWQGLGFVG-AGLGLTISRYIGAIAIIWVLMIGFNPALRI-PFKSYFKPLNLAIIWEVMGIGIPA----SIESVLFNG 277
Cdd:PRK00187  179 IEGWFGLPKLGlMGIGLVTALVSNGMALALALYIRRHPAYAAyPLRKGLSRPSRAALRELWRLGLPIggtyAVEVGLFTF 258
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476636197 278 GKLLtqmfVSGMGTSVIAGNFIAFSIAALINLPGNALGSASTIITGRRLGNGQIAQAEIQLRHVFWLSTIGLTAIAWLTA 357
Cdd:PRK00187  259 AALC----MGALGSTQLAAHQIALQIVSVAFMVPVGLSYAVTMRVGQHYGAGRLLEARRAGRVGIGFGAVVMLLFAGLFW 334
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476636197 358 PFAGVMASFYTHDQD-----VKEVIVILIWLNAAFMPIWAASWVLPAGFKGARDARFAMWVSMLGMWGCRVVAGYTLGIV 432
Cdd:PRK00187  335 LLPEAIIGLFLDRNDpafaeIVQLAVSLLAVAAWFELFDGTQTIAMGAIRGLKDARTTFLIGLACYWLVGAPLAWLLAFT 414
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 1476636197 433 LGWGVVGVWLGMFFDWAVRAALFYWRMVtgrwlWKYPRPEREKCIKQPVA 482
Cdd:PRK00187  415 LGWGAVGVWWGLALGLACAAVALTLAFE-----WKTARLLRKARASEAVA 459
MATE_like cd12082
Multidrug and toxic compound extrusion family and similar proteins; The integral membrane ...
266-464 1.67e-04

Multidrug and toxic compound extrusion family and similar proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. MATE has also been identified as a large multigene family in plants, where the proteins are linked to disease resistance. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240527 [Multi-domain]  Cd Length: 420  Bit Score: 43.85  E-value: 1.67e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476636197 266 IPASIESVLFNGGKLLTQMFVSGMGTSVIAGNFIAFSIAALINLPGNALGSASTIITGRRLGNGQIAQAEIQLRHVFWLS 345
Cdd:cd12082     2 APLLLSMLLQTLYNLVDTFFLGRLLGDALAAVGLAFPLIALLIALGVGLSVGTSALISQAIGAGDEEKARRVLVQSIVLA 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476636197 346 TIGLTAIAWLTAPFAGVMASFYTHDQDVKEVIVILIWLNAAFMPIWAASWVLPAGFKGARDARFAMWVSMLG-------- 417
Cdd:cd12082    82 ILLGLLLAALLLFFSPLILSLLGAEEEVIELAATYLTILILGLPITFLGAVLSGILQGEGDTRTAMIISVLSnllnilld 161
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....
gi 1476636197 418 -----MWGCRV--VAGYTLGIVLGWGVVGVWLGMFFDWAVRAALFYWRMVTGRW 464
Cdd:cd12082   162 pllifGLGPPElgIAGAALATVISYVIGALLLLIYLRKGKKILKFKLSLLKPDL 215
matE TIGR00797
putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A. ...
267-417 1.68e-04

putative efflux protein, MATE family; The Multi Antimicrobial Extrusion (MATE) Family (TC 2.A.66) The MATE family consists of probable efflux proteins including a functionally characterized multi drug efflux system from Vibrio parahaemolyticus, a putative ethionine resistance protein of Saccharomyces cerevisiae, and the functionally uncharacterized DNA damage-inducible protein F (DinF) of E. coli. These proteins have 12 probable TMS. [Transport and binding proteins, Other]


Pssm-ID: 273273 [Multi-domain]  Cd Length: 342  Bit Score: 43.77  E-value: 1.68e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476636197 267 PASIESVLFNGGKLLTQMFVSGMGTSVIAGNFIAFSIAALINLPGNALGSASTIITGRRLGNGQIAQAEIQLRHVFWLST 346
Cdd:TIGR00797   1 PAILANILQPLLGLVDTAFVGHLGPVDLAAVSLGSSVFMFLFSILMGLGTATTALVAQAVGAGNYQRLGRQAQQSLLLAL 80
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1476636197 347 IGLTAIAWLTAPFAGVMASFYTHDQDVKEV----IVILIWlnaaFMPIWAASWVLPAGFKGARDARFAMWVSMLG 417
Cdd:TIGR00797  81 LLGLPVLLVGYFFIDPLLSLMGADGEVAELaqdyLRILIL----GIPAYLLNFVLRGFLRGQGDTKTPMYITLIG 151
MATE_DinF_like cd13136
DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE) ...
7-180 8.17e-03

DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Escherichia coli DinF is a membrane protein that has been found to protect cells against oxidative stress and bile salts. The expression of DinF is regulated as part of the SOS system. It may act by detoxifying oxidizing molecules that have the potential to damage DNA. Some member of this family have been reported to enhance the virulence of plant pathogenic bacteria by enhancing their ability to grow in the presence of toxic compounds. Proteins from the MATE family are involved in exporting metabolites across the cell membrane and are often responsible for multidrug resistance (MDR).


Pssm-ID: 240541 [Multi-domain]  Cd Length: 424  Bit Score: 38.70  E-value: 8.17e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476636197   7 LRQVASRTPWYAKRKSYKVLFWREITPLAVPIFLENTCVLLMGVLSTFLVSWLGKEAMAGVGLADSFNMVIMAFFAAIDL 86
Cdd:cd13136   203 LRRRVRLLGKSLSRRLPSKAALKRLFKLNRDIFIRTLALLAAFLFFTALAARLGDVILAANQILLQFWLLSSYFLDGFAY 282
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476636197  87 GTTVVVAFSLGKRDRRRARAAARQSLVIMTIFATVLAAVIHYFGQQIIDVVAGEatPDVKALALTYLELTVLSYPAAAIA 166
Cdd:cd13136   283 AAEALVGRALGAGDRKAARRVARRLLQWGLGLGVLLALLFFLGGEPIIRLFTDD--PAVLALAATYLPWLALLPPIGALA 360
                         170
                  ....*....|....
gi 1476636197 167 LIGSGALRGAGNTK 180
Cdd:cd13136   361 FVLDGIFIGATDTR 374
MATE_like_2 cd13149
Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The ...
28-234 8.17e-03

Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; The integral membrane proteins from the MATE family are involved in exporting metabolites across the cell membrane and are responsible for multidrug resistance (MDR) in many bacteria and animals. A number of family members are involved in the synthesis of peptidoglycan components in bacteria.


Pssm-ID: 240554 [Multi-domain]  Cd Length: 434  Bit Score: 38.44  E-value: 8.17e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476636197  28 WREITPLAVPIFLENTCVLLMGVLSTFLVSWLGKEAMAGVGLADSFNMVIMAFFAAIDLGTTVVVAFSLGKRDRRRARAA 107
Cdd:cd13149   233 WKDILSIGIPAALSNILTPLSAAFITALVATYGPAAVAAFGVATRIESFAFIIVMALSSALGPFVGQNWGAGQYERVQEG 312
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1476636197 108 ARQSLVIMTIFATVLAAVIHYFGQQIIDVVAGEatPDVKALALTYLELTVLSYPAAAIALIGSGALRGAGNTKIPLLING 187
Cdd:cd13149   313 LKISLKFSLIYGAILGIVLALFAGWLASLFSAE--PEVIELITLYLLIVPIGYGGLGILIITSASFNALGKPLYSLGLNL 390
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 1476636197 188 GmnilniiiSSILIYGIFSWQG---LGFVGAGLGLTISRYIGAIAIIWVL 234
Cdd:cd13149   391 I--------RVFLLYIPLAYVGshlLGFAGVFIGALAGNLIAGILAYFIA 432
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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