|
Name |
Accession |
Description |
Interval |
E-value |
| 2A0114 |
TIGR00893 |
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, ... |
25-434 |
5.17e-134 |
|
D-galactonate transporter; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273326 [Multi-domain] Cd Length: 399 Bit Score: 391.31 E-value: 5.17e-134
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 25 IVTAVNYADRATLSIAGTEVAKELQLSAVSMGYIFSAFGWAYLLMQIPGGWLLDKFGSKKVYTYSLFFWSLFTFLQGFVD 104
Cdd:TIGR00893 1 LVTVINYLDRANLSFAAPMLQEDLGLSAAQYGYVFSAFSWGYVVGQFPGGWLLDRFGARKTLAVFIVIWGVFTGLQAFAG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 105 MFPlawagiSMFFMRFMLGFSEAPSFPANARIVAAWFPTKERGTASAIFNSAQYFSLALFSPLLGWLTFAWGWEHVFTVM 184
Cdd:TIGR00893 81 AYV------SLYILRVLLGAAEAPFFPGIILIVASWFPASERATAVSIFNSAQGLGGIIGGPLVGWILIHFSWQWAFIIE 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 185 GVIGFVLTALWIKLIHNPTDHPRMSAEELKFISENGAVVDMDHKKPgsaaaSGPKLHYIKQLLSNRMMLGVFFGQYFINT 264
Cdd:TIGR00893 155 GVLGIIWGVLWLKFIPDPPQKAKWLTEEEKYIVVGGLLAEQQGKGP-----STPKKYQIKELLKDRRVWGLALGQFLVNI 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 265 ITWFFLTWFPIYLVQEKGMSILKVGLVASIPALCGFAGGVLGGVFSDYLIKRGLSLTLARKLPIVLGMLLASTIILCNYT 344
Cdd:TIGR00893 230 GLGFFLTWFPTYLVQERGLSILEAGFMASLPGIVGFIGMILGGRLSDLLLRRGKSLVFARKTAIIAGLVLSLLMFATNYV 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 345 NNTTLVVMLMALAFFGKGFGALGWPVISDTAPKEIVGLCGGVFNVFGNVASIVTPLVIGYLVSELHSFNAALVFVGCSAL 424
Cdd:TIGR00893 310 NIPYAALALVALGFFGLGAGAIGWALISDNAPGNIAGLTGGLINSLGNLGGIVGPIVIGAIAATTGSFAGALMVVAALAL 389
|
410
....*....|
gi 1487549706 425 MAMVCYLFVV 434
Cdd:TIGR00893 390 IGALSYLLLV 399
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
16-433 |
6.92e-105 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 315.28 E-value: 6.92e-105
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 16 RYLILLIIFIVTAVNYADRATLSIAGTEVAKELQLSAVSMGYIFSAFGWAYLLMQIPGGWLLDKFGSKKVYTYSLFFWSL 95
Cdd:cd17319 1 RWRIIPLLFLAYVINYLDRVNISVAAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 96 FTFLQGFVDMFplawagISMFFMRFMLGFSEAPSFPANARIVAAWFPTKERGTASAIFNSAQYFSLALFSPLLGWLTFAW 175
Cdd:cd17319 81 FTALTGFATSL------TSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPLGAAIGPPLSGWLLLLF 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 176 GWEHVFTVMGVIGFVLTALWIKLIhnptdhprmsaeelkfisengavvdmdhkkpgsaaasgpklhyikqllsnRMMLGV 255
Cdd:cd17319 155 GWRWAFIIEGLLGLLLAVLWWFYL--------------------------------------------------RQVWGL 184
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 256 FFGQYFINTITWFFLTWFPIYLVQEKGMSILKVGLVASIPALCGFAGGVLGGVFSDYLIkrglslTLARKLPIVLGMLLA 335
Cdd:cd17319 185 ALGYFGINYALYGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLL------RGARRLVIIIGLLLA 258
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 336 STIILCNYTN-NTTLVVMLMALAFFGKGFGALG-WPVISDTAPKEIVGLCGGVFNVFGNVASIVTPLVIGYLVSELHSFN 413
Cdd:cd17319 259 AVGLLLAYLTtSPVVAVILLSLAGFGIGAASPVfWSLPADLLPGEAAATAGGLINSGGNLGGFVAPLLIGYLVDATGSYT 338
|
410 420
....*....|....*....|
gi 1487549706 414 AALVFVGCSALMAMVCYLFV 433
Cdd:cd17319 339 AAFLFLAAVALLAALLVLLL 358
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
9-439 |
7.13e-69 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 222.82 E-value: 7.13e-69
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 9 KKKGVHTRYLILLIIFIVTAVNYADRATLSIAGTEVAKELQLSAVSMGYIFSAFGWAYLLMQIPGGWLLDKFGSKKVYTY 88
Cdd:COG2271 1 ARAPSRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 89 SLFFWSLFTFLQGFVDMFPlawagiSMFFMRFMLGFSEAPSFPANARIVAAWFPTKERGTASAIFNSAQYFSLALFSPLL 168
Cdd:COG2271 81 GLLLWGLATLLFGFATSFW------QLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLL 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 169 GWLTFAWGWEHVFTVMGVIGFVLTALwiklihnptdhprmsaeelkfisengavvdmdhkkpgsaaasgpklhyikqlls 248
Cdd:COG2271 155 GWLLAAFGWRAAFLILGLPGLLLALL------------------------------------------------------ 180
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 249 nrMMLGVFFGQYFINTITWFFLTWFPIYLVQEKGMSILKVGLVASIPALCGFAGGVLGGVFSDYLIKRglsltlaRKLPI 328
Cdd:COG2271 181 --RFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRR-------RKLVL 251
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 329 VLGMLLAS-TIILCNYTNNTTLVVMLMALA-FFGKGFGALGWPVISDTAPKEIVGLCGGVFNVFGNVASIVTPLVIGYLV 406
Cdd:COG2271 252 AIGLLLAAlALLLLALLPSPALAIALLFLAgFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLL 331
|
410 420 430
....*....|....*....|....*....|...
gi 1487549706 407 sELHSFNAALVFVGCSALMAMVCYLFVVGDIKR 439
Cdd:COG2271 332 -DATGYQAAFLLLAALALLAALLALLLLRETRK 363
|
|
| 2A0104 |
TIGR00881 |
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ... |
24-407 |
6.16e-55 |
|
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273319 [Multi-domain] Cd Length: 379 Bit Score: 187.20 E-value: 6.16e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 24 FIVTAVNYADRATLSIAGTEVAKELQLSAVSMGYIFSAFGWAYLLMQIPGGWLLDKFGSKKVYTYSLFFWSLFTFLQGFV 103
Cdd:TIGR00881 1 FIGYAAYYLVRKNFALAMPYLVEEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 104 DMFPlawagiSMFFMRFMLGFSEAPSFPANARIVAAWFPTKERGTASAIFNSAQYFSLALFSPLLG-WLTFAWGWEHVFT 182
Cdd:TIGR00881 81 TSLW------VMAALWALNGIFQGMGWPPCGRTVTKWFSRSERGTWVSFWNCSHNVGGGLLPPLVLfGIAELYSWHWVFI 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 183 VMGVIGFVLTALWIKLIHNPTDHPRMSAEELKFISEngavvdMDHKKPGSAAASGPKLHYIKQLLSNRMMLGVFFGQYFI 262
Cdd:TIGR00881 155 VPGIIAIIVSLICFLLLRDSPQSCGLPPAEEMPNEE------PDGDAEKKEEELTKKQIFLQYVLLNKVLWYISLGYVFV 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 263 NTITWFFLTWFPIYLVQEKGMSILKVGLVASIPALCGFAGGVLGGVFSDYLIK-RGLSLTLARKLPIVLGMLlastIILC 341
Cdd:TIGR00881 229 YVVRTGILDWSPLYLTQEKGFSKEKASWAFTLYELGGLVGTLLAGWLSDKLFNgRRGPLAVFFMALIIVSLL----VYWL 304
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1487549706 342 NYTNNTTLVVM-LMALAFFGKGFGALGWPVISDTAPKEIVGLCGGVFNVFGNVASIVTPLVIGYLVS 407
Cdd:TIGR00881 305 NPAANPLMDLIcLFALGFLVYGPQMLIGVIASELAPKKAAGTAAGFVGFFAYLGGILAGLPLGYLAD 371
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
16-433 |
7.38e-45 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 160.82 E-value: 7.38e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 16 RYLILLIIFIVTAVNYADRATLSIAGTEVAKELQLSAVSMGYIFSAFGWAYLLMQIPGGWLLDKFGSKKVYTYSLFFWSL 95
Cdd:COG2223 3 RWRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGI 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 96 FTFLQGFVDMFPLawagisMFFMRFMLGFSEAPSFPANARIVAAWFPTKERGTASAIFNSAQYFSLALFSPLLGWLTFAW 175
Cdd:COG2223 83 GLLLLALAVSYWL------LLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAF 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 176 GWEHVFTVMGVIGFVLTALWIKLIHNPtdhprmsaeelkfisengavvdmdhkKPGSAAASGPKLHYIKQLLSNRMMLGV 255
Cdd:COG2223 157 GWRNAFLILGILLLVVAVLAWLFLRDP--------------------------PAGAAAAAKASLRDQLEALRDPRFWLL 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 256 FFGQYFINTITWFFLTWFPIYLVQEKGMSILKVGLVASIPALCGFAGGVLGGVFSDYLIKRglsltlaRKLPIVLGMLLA 335
Cdd:COG2223 211 SLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGR-------RVLLIVFALMAL 283
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 336 STIILCNYTNNTTLVVMLMALAFFGKGFG-ALGWPVISDTAPKEIVGLCGGVFNVFGNVASIVTPLVIGYLVSELHSFNA 414
Cdd:COG2223 284 GLLLLALALGSLWLFLVLFLLLGLALGGGnGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGSYTA 363
|
410
....*....|....*....
gi 1487549706 415 ALVFVGCSALMAMVCYLFV 433
Cdd:COG2223 364 AFLVFAVLALVALVLTLLL 382
|
|
| MFS_SLC17 |
cd17318 |
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The ... |
21-434 |
1.53e-44 |
|
Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily of transporters; The Solute carrier 17 (SLC17) family is primarily involved in the transport of organic anions. There are nime human proteins belonging to this family including: the type I phosphate transporters (SLC17A1-4) that were initially identified as sodium-dependent inorganic phosphate (Pi) transporters but are now known to be involved in tha transport of organic anions; lysosomal acidic sugar transporter (SLC17A5 or sialin), vesicular glutamate transporters (VGluT1#3 or SLC17A7, SLC17A6, and SLC17A8, respectively), and a vesicular nucleotide transporter (VNUT or SLC17A9). SLC17A1 and SLC17A3 have roles in the transport of urate and para-aminohippurate, respectively. The SLC17 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340876 [Multi-domain] Cd Length: 389 Bit Score: 159.71 E-value: 1.53e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 21 LIIFIVTAVNYADRATLSIA----------------------GTEVAKELQLSAVSMGYIFSAFGWAYLLMQIPGGWLLD 78
Cdd:cd17318 2 ILLFLGFAVVYAMRVNLSVAivamvnstathdnnntstdkdtLPVEAPEFDWSEKTQGIILSSFFYGYILTQIPGGYLAE 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 79 KFGSKKVYTYSLFFWSLFTFLqgfvdMFPLAWAG-ISMFFMRFMLGFSEAPSFPANARIVAAWFPTKERGTASAIFNSAQ 157
Cdd:cd17318 82 KYGAKRVLGYSILITALLTLL-----TPLAARGGyGALIVLRILQGLAQGVTFPAMHALWAKWAPPLERSRLTSIAYSGS 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 158 YFSLALFSPLLGWLTFAWGWEHVFTVMGVIGFVLTALWIKLIhnptdhprmsaeelkfisengavvdmdhkkpgsaaasg 237
Cdd:cd17318 157 QFGTVIAMPLSGFLCESLGWPSIFYIFGGLGLLWCLLWFFLV-------------------------------------- 198
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 238 pklhyikqllsnRMMLGVFFGQYFINTITWFFLTWFPIYLVQEKGMSILKVGLVASIPALCGFAGGVLGGVFSDYLIKRG 317
Cdd:cd17318 199 ------------LPVWAIVVAHFGHNWGFYTLLTELPTYMSDVLHFNIKSNGFLSSLPYLAMWICSIVGGYLADWLRSRG 266
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 318 -LSLTLARKLPIVLGMLLASTIILC-NYTN-NTTLVVMLMALAFfgkGFGALGWPVIS----DTAPKeIVGLCGGVFNVF 390
Cdd:cd17318 267 iLSTTTVRKLFTSIGFLGPGVFLIAlGYLGsNATLAVVFLTLSV---GLSGACYSGFLvnhlDLAPN-YAGTLMGITNTA 342
|
410 420 430 440
....*....|....*....|....*....|....*....|....*
gi 1487549706 391 GNVASIVTPLVIGYLVSELHSFNA-ALVFvGCSALMAMVCYLFVV 434
Cdd:cd17318 343 ATIAGIISPLIVGAIVKNDQTIGQwRIVF-FISAAIYILGAIFYL 386
|
|
| MFS_SLC17A9_like |
cd17380 |
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of ... |
24-424 |
7.28e-44 |
|
Solute carrier family 17 member 9 and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily includes solute carrier family 17 member 9 (SLC17A9) and similar proteins including plant inorganic phosphate transporters (PHT4) that are also probably anion transporters. SLC17A9, also called vesicular nucleotide transporter (VNUT), is involved in vesicular storage and exocytosis of ATP. It facilitates the accumulation of ATP and other nucleotides in secretory vesicles such as adrenal chromaffin granules and synaptic vesicles. It also functions as a lysosomal ATP transporter and regulates cell viability. Plant PHT4 family transporters mediate the transport of inorganic phosphate and may also transport organic anions. The Arabidopsis protein AtPHT4;4 is a chloroplast-localized ascorbate transporter. PHT4 proteins show differential expression that suggests specialized functions. The SLC17A9-like subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340938 [Multi-domain] Cd Length: 361 Bit Score: 157.33 E-value: 7.28e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 24 FIVTAVNYADRATLSIAGTEVAKELQLSAVSMGYIFSAFGWAYLLMQIPGGWLLDKFGSKKVYTYSLFFWSLFTFLQGFv 103
Cdd:cd17380 5 FLATCICYADRVNMPIAIVPMAKEFGWSKTDQGLVLSSFFWGYALTQVLGGYLADRFGGKKVLLLAVALWSLATLLTPL- 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 104 dmfpLAWAGI-SMFFMRFMLGFSEAPSFPANARIVAAWFPTKERGTASAIFNSAQYFSLALFSPLLGWLTFAWGWEHVFT 182
Cdd:cd17380 84 ----LAYSSLpLLILSRILLGLGEGVHFPSMTSLFSRWVPVSERSRAVSIVTAGSYLGTLLGGLIGPLLLEYYGWPSVFY 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 183 VMGVIGFVLTALWiklihnptdhprmsaeeLKFISENGAVVdmdhkkpgsaaasgpklhyikqlLSNRMMLGVFFGqyfi 262
Cdd:cd17380 160 FFGLLGLLWALVW-----------------LIYLPPVWAII-----------------------VAHFCMNWGFYI---- 195
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 263 ntitwfFLTWFPIYLvQEKGMSILKVGLVASIPALCGFAGGVLGGVFSDYLIKRGLSLTLARKLPIVLGMLLASTIILC- 341
Cdd:cd17380 196 ------LLSWLPTYF-HEVLVPLAKGWVFNVVPWLVMFPSSNVAGWLADHLISRGWTVTSVRKLMQSIGFLGPALFLLLl 268
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 342 NYTNNTTLVVMLMALAFFGKGFGALGWPV-ISDTAPKEiVGLCGGVFNVFGNVASIVTPLVIGYLVSELHSFnaALVFVG 420
Cdd:cd17380 269 SHTDSFSLALLCMSVALGLSAFSSSGVLVnHQDIAPNY-AGIVFGISNTAGTIPGIVGVYLTGYILEATGSW--SLVFVL 345
|
....
gi 1487549706 421 CSAL 424
Cdd:cd17380 346 AAVV 349
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
15-395 |
2.71e-31 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 122.78 E-value: 2.71e-31
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 15 TRYLILLIIFIVTAVNYADRATLSIAGTEVAKELQLSAVSMGYIFSAFGWAYLLMQIPGGWLLDKFGSKKVYTYSLFFWS 94
Cdd:COG2814 7 RRWLALLALALGAFLSGLGIGIVLPALPLIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFA 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 95 LFTFLQGFVDMFPLawagisMFFMRFMLGFSEAPSFPANARIVAAWFPTKERGTASAIFNSAQYFSLALFSPLLGWLTFA 174
Cdd:COG2814 87 LGSLLCALAPSLWL------LLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 175 WGWEHVFTVMGVIGFVLTALWIKLIHNPTDHPRmsaeelkfisengavvdmdhkkpgsaaasGPKLHYIKQLLSNRMMLG 254
Cdd:COG2814 161 FGWRWVFLVNAVLALLALLLLLRLLPESRPAAR-----------------------------ARLRGSLRELLRRPRLLL 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 255 VFFGQYFINTITWFFLTWFPIYLVQEKGMSILKVGLVASIPALCGFAGGVLGGVFSDYLIKRGLsltlarkLPIVLGMLL 334
Cdd:COG2814 212 LLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFGRRRL-------LLIGLLLLA 284
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1487549706 335 ASTIILCNYTNNTTLVVMLMALAFFGKGFGALGWPVISDTAPKEIVGLCGGVFNVFGNVAS 395
Cdd:COG2814 285 LGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGG 345
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
23-431 |
2.85e-30 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 120.61 E-value: 2.85e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 23 IFIVTAVNYADRATLSIAGTEVAKELQLSAVSMGYIFSAFGWAYLLMQIPGGWLLDKFGSKKVYTYSLFFWSLFTFLQGF 102
Cdd:cd06174 1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 103 VDMFPLAWAGismffmRFMLGFSEAPSFPANARIVAAWFPTKERGTASAIFNSAQYFSLALFSPLLGWLT--FAWGWEHV 180
Cdd:cd06174 81 APSFWLLLLG------RFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILAssLGFGWRAV 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 181 FTVMGVIGFVLTALWIKLIHNPTDHPRmsaeelkfisengavvdmdhkKPGSAAASGPKLHYIKQLLSNRMMLGVFFGQY 260
Cdd:cd06174 155 FLIAAALALLAAILLLLVVPDPPESAR---------------------AKNEEASSKSVLKLLKRVLKNPGLWLLLLAIF 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 261 FINTITWFFLTWFPIYLVQEKGMSILKVGLVASIPALCGFAGGVLGGVFSDYLIKRglsltlARKLPIVLGMLLASTIIL 340
Cdd:cd06174 214 LVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGR------KPLLLIGLLLMALGLALL 287
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 341 CNYTNNTTLVVMLMALAFFGKGFGALGWPVISDTAPKEIVGLCGGVFNVFGNVASIVTPLVIGYLVSELHSFNAALVFVG 420
Cdd:cd06174 288 LLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGLTGAFLVLA 367
|
410
....*....|.
gi 1487549706 421 CSALMAMVCYL 431
Cdd:cd06174 368 VLLLLAAILLL 378
|
|
| 2A0114euk |
TIGR00894 |
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions] |
51-407 |
4.11e-30 |
|
Na(+)-dependent inorganic phosphate cotransporter; [Transport and binding proteins, Anions]
Pssm-ID: 129972 [Multi-domain] Cd Length: 465 Bit Score: 121.39 E-value: 4.11e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 51 SAVSMGYIFSAFGWAYLLMQIPGGWLLDKFGSKKVYTYSLFFWSLFTFLqgfvdMFPLAWAGISM-FFMRFMLGFSEAPS 129
Cdd:TIGR00894 74 SGALQGLILSSHFYGQIIIQIPVGYLAGKYVFKWSIGIGMFLSSVISIV-----IPWAAGGGIALvVFCRVIQGLAQGSV 148
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 130 FPANARIVAAWFPTKERGTASAIFNSAQYFSLALFSPLLGWLTFAW-GWEHVFTVMGVIGFVLTALWIKLIH-NPTDHPR 207
Cdd:TIGR00894 149 SPATHKIIVKWAPPKERSRLLGMSTSGFQLGTFIFLPISGWLCESWgGWPMIFYVFGIVGCAWSLLWFVFPAdDPSIHPC 228
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 208 MSAEELKFIseNGAVVDMDHKKPGSAAasgpklhyIKQLLSNRMMLGVFFGQYFINTITWFFLTWFPIYLVQEKGMSILK 287
Cdd:TIGR00894 229 ISKFEKKYI--NSSLQGQKGSTRQSLP--------IKAIPKSLPVWAIWFAIFGHFWLYTILPTYLPTFISWVLRVSGKE 298
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 288 VGLVASIPALCGFAGGVLGGVFSDYLIKRG-LSLTLARKLPIVLGMLLASTIILCNY--TNNTTLVVMLMALAFFGKGFG 364
Cdd:TIGR00894 299 NGLLSSLPYLFAWLCSIFAGYLADFLKSSKtLSLTAARKIFNGIGGLGPGIFAYALPylSAAFYLTIIILTLANAVSSGP 378
|
330 340 350 360
....*....|....*....|....*....|....*....|....
gi 1487549706 365 ALGWPVIS-DTAPKeIVGLCGGVFNVFGNVASIVTPLVIGYLVS 407
Cdd:TIGR00894 379 LAGVLINSlDLAPR-FLGFIKGITGLPGFIGGLIASTLAGNILS 421
|
|
| MFS_MT3072_like |
cd17475 |
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ... |
47-428 |
3.53e-29 |
|
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341028 [Multi-domain] Cd Length: 378 Bit Score: 117.34 E-value: 3.53e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 47 ELQLSAVSMGYIFSAFGWAYLLMQIPGGWLLDKFGSKKVYTYSLFFWSLFTFLQGFVDMFPLAWAGIsmffmrFMLGFSE 126
Cdd:cd17475 25 DLHLSLAQVGLLLSALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGSYPVLLVLL------FLVGAGY 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 127 APSFPANARIVAAWFPTKERGTASAIFNSAQYFSLALFSPLLGWLTFAWGWEHVFTVMGVIGFVLTALWIKLIHNPTDhp 206
Cdd:cd17475 99 GSVQPGGGRAIMRWFPPRERGLAMGIRQTGVPLGGALAAALLPPLALHYGWRAAFVVAGLVSILAAVLFWLFYREPPA-- 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 207 rmsaeelkfisengavvdmdhkKPGSAAASGPKLHYIKQLLSNRMMLGVFFGQYFINTITWFFLTWFPIYLVQEKGMSIL 286
Cdd:cd17475 177 ----------------------ASAATESASTLLRSLKEVLRNRDVWLIAIAGALLVAPQFALLTFLLLFLHDHLGLSVV 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 287 KVGLVASIPALCGFAGGVLGGVFSDYLIKRglsltlARKLPIVLGMLLASTIILCNYTNNTTLVVMLMALAFFGKGFGAL 366
Cdd:cd17475 235 AAGALLAVAQLGGALGRIGLGRVSDRVFGG------RRRPVLVITAAIAAAALLVLSLLSPGTPLWLLVLLLILLGLFAI 308
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1487549706 367 GW-----PVISDTAPKEIVGLCGGVFNVFGNVASIVTPLVIGYLVSELHSFNAA-LVFVGCSALMAMV 428
Cdd:cd17475 309 GWnglylTLVAESAGPEQAGTALGLANTINFIGIAIGPPLFGLLVDATHSYAPAwLALALLLVLAALL 376
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
45-428 |
5.83e-29 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 116.91 E-value: 5.83e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 45 AKELQLSAVSMGYIFSAFGWAYLLMQIPGGWLLDKFGSKKVYTYSLFFWSLFTFLQGFVDMFPLawagisMFFMRFMLGF 124
Cdd:cd17325 23 AESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQ------LLLARFLQGL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 125 SEAPSFPANARIVAAWFPTKERGTASAIFNSAQYFSLALFSPLLGWLTFAWGWEHVFTVMGVIGFVLTALWIKLIHNPtd 204
Cdd:cd17325 97 ASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLALLLLPEP-- 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 205 hprmsaeelkfisengavvdmDHKKPGSAAASGPKLHYIKQLLSNRMMLGVFFGQYFINTITWFFLTWFPIYLVQEKGMS 284
Cdd:cd17325 175 ---------------------RPPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLS 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 285 ILKVGLVASIPALCGFAGGVLGGVFSDYLIkrglsltlaRKLPIVLGMLL-ASTIILCNYTNNTTLVVMLMALAFFGKGF 363
Cdd:cd17325 234 PAQIGLLFGAQGLASALSQPPAGKLSDRIG---------RKPLILIGLLLsAVALLLLPLATSFWLLLLLLALLGLGLGL 304
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1487549706 364 GALGW-PVISDTAPKEIVGLCGGVFNVFGNVASIVTPLVIGYLVSelhSFNAALVFVGCSALMAMV 428
Cdd:cd17325 305 VFPATlALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYD---AFGFATPFLAAAALLLLA 367
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
23-399 |
1.16e-28 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 115.21 E-value: 1.16e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 23 IFIVTAVNYADRATLSIA-GTEVAKELQLSAVSMGYIFSAFGWAYLLMQIPGGWLLDKFGSKKVYTYSLFFWSLFTFLQG 101
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPAlPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 102 FVDMFPLawagisMFFMRFMLGFSEAPSFPANARIVAAWFPTKERGTASAIFNSAQYFSLALFSPLLGWLTFAWGWEHVF 181
Cdd:pfam07690 81 FASSLWL------LLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAF 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 182 TVMGVIGFVLTALWIKLIHNPtdhprmsaeelkfisengavvdmDHKKPGSAAASGPKLHYIKQLLSNRMMLGVFFGQYF 261
Cdd:pfam07690 155 LILAILSLLAAVLLLLPRPPP-----------------------ESKRPKPAEEARLSLIVAWKALLRDPVLWLLLALLL 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 262 INTITWFFLTWFPIYlVQEKGMSILKVGLVASIPALCGFAGGVLGGVFSDYLIKRglsltlaRKLPIVLGMLLASTIILC 341
Cdd:pfam07690 212 FGFAFFGLLTYLPLY-QEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRR-------RRLLLALLLLILAALGLL 283
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1487549706 342 NYTNNTTLVVMLMALAFFGKGFGALGWPV---ISDTAPKEIVGLCGGVFNVFGNVASIVTP 399
Cdd:pfam07690 284 LLSLTLSSLWLLLALLLLGFGFGLVFPALnalVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| MFS_spinster_like |
cd17328 |
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ... |
20-373 |
7.62e-26 |
|
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340886 [Multi-domain] Cd Length: 405 Bit Score: 108.48 E-value: 7.62e-26
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 20 LLIIFIVTAVNYADRATLSIAGTEVAKELQLSAVSMGYIFSAFGWAYLLMQIPGGWLLDKFGSKKVYTYSLFFWSLFTFL 99
Cdd:cd17328 1 VAVLFLINLLNYMDRFTIAGVLPDIQSDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 100 QGFVDMFPLawagisMFFMRFMLGFSEAPSFPANARIVAAWFPTKERGTASAIFNSAQYFSLALFSPLLGWLTFAW-GWE 178
Cdd:cd17328 81 SSFAPNFWQ------LLLFRALVGIGEASYSPIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQATgGWR 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 179 HVFTVMGVIGFVLTALWIKLIHNPtdhPRMSAEElkfisengavVDMDHKKPGSAAASgpklhyIKQLLSNRMMLGVFFG 258
Cdd:cd17328 155 WAFRVTGVLGVLLAILLLLFVREP---PRGAAEG----------GVMAKSTATSFLAD------LKALAKNPSFILSTLG 215
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 259 qYFINTITWFFLT-WFPIYLVQEKGMSILKVGLVA----SIPALCGFAGGVLGGVFSDYLIKRGLSltlARKLPIVLGML 333
Cdd:cd17328 216 -FTAVSFVTGALAfWAPTFFLRAFGVGDLSSADVGlifgAITCIAGVLGVLLGGILADRLRRKTPR---ADPLVCAVGLL 291
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 1487549706 334 LASTIILCNYTNNTTLVVMLMALAFFGKGFGALGWPVISD 373
Cdd:cd17328 292 AAAPFLFLALVLALSNLLLAWVLLFLGEFLLSLNWAPVFA 331
|
|
| MFS_GlpT |
cd17345 |
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ... |
16-433 |
2.11e-25 |
|
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340903 [Multi-domain] Cd Length: 411 Bit Score: 107.33 E-value: 2.11e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 16 RYLILLIIFIVTAVNYADRATLSIAGTEVAKELQLSAVSMGYIFSAFGWAYLLMQIPGGWLLDKFGSKKVYTYSLFFWSL 95
Cdd:cd17345 1 RWQVFLGIFIGYAGYYLVRNNFSLAQPYLIEQYGLSKTEIGLIGSALSIAYGLSKFVMGNLSDRSNPKRFLAIGLILSAI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 96 FTFLQGFVDmfplaWAGIS---MFFMRFMLGFSEAPSFPANARIVAAWFPTKERGTASAIFNSAQYFSLALFSPLLGW-- 170
Cdd:cd17345 81 INILIGFVP-----SATSSvglMFILLFLNGWFQGMGWPPSGRTMVHWFSKKERGTWTSIWNISHNVGGGLVGPLAGLgl 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 171 -LTFAWGWEHVFTVMGVIGFVLTALWIKLIH-NPTDHPRMSAEELKfisenGAVVDMDHKKPGSAAASGPKLhYIKQLLS 248
Cdd:cd17345 156 aIFGDGWWRGAFIFPAIIAIIVAVIVLFLGKdTPESEGLPPIEEYK-----GDYPEEADGEEEEQELSAWEI-FVKYVLK 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 249 NRMMLGVFFGQYFINTITWFFLTWFPIYLVQEKGMSILKVGLVASIPALCGFAGGVLGGVFSDYLIKrglsltlARKLPI 328
Cdd:cd17345 230 NKLLWYIAIANVFVYLVRYGILDWAPTYLSEVKGFSKAQAMWAFSLFEWAAIPGTLLAGWLSDKLFK-------GRRAPT 302
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 329 VLGMLLASTIILCNYTNNTTLVVMLMALAFFGK---------GFGALgwpvisDTAPKEIVGLCGGVFNVFGNV-ASIVT 398
Cdd:cd17345 303 GIIFMILVIVALIVYWLAPNVLVDLIALIALGFliygpvmliGLQAL------ELVPKKAAGTAAGLTGLFGYLgGSVLA 376
|
410 420 430
....*....|....*....|....*....|....*
gi 1487549706 399 PLVIGYLVsELHSFNAALVFVGCSALMAMVCYLFV 433
Cdd:cd17345 377 TALIGIIV-DHFGWNGGFIVLLASCILAIIFLALV 410
|
|
| MFS_OPA_SLC37 |
cd17312 |
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of ... |
16-433 |
2.75e-23 |
|
Organophosphate:Pi antiporter/Solute Carrier family 37 of the Major Facilitator Superfamily of transporters; Organophosphate:Pi antiporters (OPA) are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA family is also called solute carrier family 37 (SLC37) in vertebrates. Members include glucose-6-phosphate (Glc6P) transporter (also called translocase or exchanger), glycerol-3-phosphate permease, 2-phosphonopropionate transporter, phosphoglycerate transporter, as well as membrane sensor protein UhpC from Escherichia coli. UhpC is both a sensor and a transport protein; it recognizes external Glc6P and induces transport by UhpT, and it can also transport Glc6P. Vertebrates contain four SLC37 or sugar-phosphate exchange (SPX) proteins: SLC37A1 (SPX1), SLC37A2 (SPX2), SLC37A3 (SPX3), and SLC37AA4 (SPX4). The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340870 [Multi-domain] Cd Length: 364 Bit Score: 100.43 E-value: 2.75e-23
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 16 RYLILLIIFIVTAVNYADRATLSIAGTEVAKELQLSAVSMGYIFSAFGWAYLLMQIPGGWLLDKFGSKKVYTYSLFFWSL 95
Cdd:cd17312 1 RWRIFLGVFLGYAAYYVCRKNFSVAKPPIVEEIGLSKDDLGIIGSAFLIAYAVGKFISGFLSDRSNIRRFMSAGLLLSAL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 96 FTFLQGFVDMFPLawagisMFFMRFMLGFSEAPSFPANARIVAAWFPTKERGTASAIFNSAQYFSLALFSPLLGWLTFAW 175
Cdd:cd17312 81 ANIFMGFSTSLWF------FAVLWGLNGLFQSMGWPPCVKLLGNWFSKKERGTVYGIWSTSHNFGGILAPILAASLASYY 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 176 GWEHVFTVMGVIGFVLTALWIKLIHNptdhprmsaeelkfisengavvdmdhkkpgsaaasgpklhyikqllSNRMMLGV 255
Cdd:cd17312 155 GWRAAFLVPGIVGLVVAIILFFFLRD----------------------------------------------SPPYVWVL 188
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 256 FFGQYFINTITWFFLTWFPIYLVQEKGMSILKVGLVASIPALCGFAGGVLGGVFSDYLIKrglsltlARKLPIVLGMLLA 335
Cdd:cd17312 189 SLAYAFVYIVRYACLDWGPLYLYEVKGYSLIDAGWFSSLYEVGGIAGTILAGLLSDKLFG-------GRRAPIAVIYMLL 261
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 336 STIILCNY---TNNTTLVVMLMALA-FFGKGFGALGWPVIS-DTAPKEIVGLCGGVFNVFGNVASIVTPLVIGYLVSELH 410
Cdd:cd17312 262 MTLSLALFwffPHNKLLSIVLLFLIgFFVGGPINLIGGAAAqDIGRKEAAGTATGFVGLFGYLGASLAGLPLGYIIDHYG 341
|
410 420
....*....|....*....|...
gi 1487549706 411 SFNAALVFVGCSALMAMVCYLFV 433
Cdd:cd17312 342 WSTVFYFLISAALLSVLLLLSLW 364
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
20-431 |
7.25e-21 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 93.44 E-value: 7.25e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 20 LLIIFIVTAVNYADRATLSIAGTEVAKE--LQLSAVSMGYIFSAFGWAYLLMQIPGGWLLDKFGSKKVYTYSLFFWSLFT 97
Cdd:cd17316 1 LLLAGLGWFFDAYDFFLIGFVAPVLAAEfsLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLAT 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 98 FLQGFvdmfplAWAGISMFFMRFMLGFSEAPSFPANARIVAAWFPTKERGTASAIFNSAQY----FSLALFSPLLGWLTF 173
Cdd:cd17316 81 LLIGL------LPTPILLLVLRFLQGIGIGGEYPGASTYVAEFAPSKRRGFALGLLQSGWAlgalLAALVASLLIPLLSG 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 174 AWGWEHVFTVMGVIGFVLTALWIKLIhnptdhprmsaeelkfisengavvdmdhkkpgsaaasgpklhyikqllsnrMML 253
Cdd:cd17316 155 DWGWRILFLIGALPALLALLLRRRTL---------------------------------------------------LLI 183
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 254 GVFFgqyFINTITWFFLTWFPIYLVQEKGMSILKVGLVASIPALCGFAGGVLGGVFSDYlikrglsltLARKLPIVLGML 333
Cdd:cd17316 184 LLWF---FISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDR---------IGRKKTLVIGLI 251
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 334 LASTII----LCNYTNNTTLVVMLMALAFFGKGFGALGWPVISDTAPKEIVGLCGGVFNVFGNVASIVTPLVIGYLVSEL 409
Cdd:cd17316 252 LSGILAlplfYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLAST 331
|
410 420
....*....|....*....|..
gi 1487549706 410 HSFNAALVFVGCSALMAMVCYL 431
Cdd:cd17316 332 GGTGVPALILALLAIVALIVAL 353
|
|
| MFS_FEN2_like |
cd17327 |
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ... |
17-399 |
1.74e-20 |
|
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340885 [Multi-domain] Cd Length: 406 Bit Score: 93.08 E-value: 1.74e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 17 YLILLIIFIVTAVNYADRATLSIAGTEVAKE-LQLSAVSMGYIFSAFGWAYLLMQIPGGWLLDKFGSKKVYTYSLFFWSL 95
Cdd:cd17327 4 LFILPLLCILYFLQYLDKSNISNAAVMGMKEdLKLVGNQYNWGNTVFYVGYIIFELPGNLLLQRFPPSKWLSVFIVLWGL 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 96 FTFLQGFVDMFPlawagiSMFFMRFMLGFSEAPSFPANARIVAAWFPTKERGTASAIFNSAQYFSLAL-------FSPLL 168
Cdd:cd17327 84 LTLLTAAVKNFG------GLIALRFFLGLFESGVFPGFILYLGMWYKREEQAKRIAFFYAAAGLGSIFggllaygVFKIL 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 169 GWLTFAwGWEHVFTVMGVIGFVLT-ALWIKLIHNPTDHPRMSAEELKFISENgaVVDMDHKKPgsaaASGPKLHYIKQLL 247
Cdd:cd17327 158 GVGGLA-GWRWLFIIEGLITIIIGlVIFFWLPDNPSKAWFLTEEEKELAVER--LRANQTGKG----DQKFKWKQIKEAF 230
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 248 SNRMMLGVFFGQYFINTITWFFLTWFPIyLVQEKGMSILKVGLVASIPALCGFAGGVLGGVFSDYLIKRGLSLTLARKLP 327
Cdd:cd17327 231 KDPRTWLLFLFFFCSQITNNGISNFLPL-ILKSLGFYSLQTNLLSVPIGALGAVSLLIAALLSDRFKKRGLFAIFACVLA 309
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1487549706 328 IV-LGMLLASTIILCNYtnnttlVVMLMALAFFGKGFGALGWPVISDTAPKEIVGLCGGVFNVFGNVASIVTP 399
Cdd:cd17327 310 LVgSIILLAAPNPPGAY------FAAYILGGGSYAGFPILLSWISSNCAGYTKRATVLAIMLIFYNVGNIVAP 376
|
|
| MFS_SLC37A4 |
cd17343 |
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute ... |
16-437 |
2.78e-20 |
|
Solute carrier family 37 member 4 of the Major Facilitator Superfamily of transporters; Solute carrier family 37 member 4 (SLC37A4), one of four SLC37 family proteins in vertebrates, is better known as glucose-6-phosphate transporter (G6PT). It is also called sugar phosphate exchanger 4 (SPX4), G6P translocase, or transformation-related gene 19 protein (TRG-19). G6PT is a phosphate (Pi)-linked G6P antiporter, catalyzing G6P:Pi and Pi:Pi exchanges. Deficiencies in human G6PT lead to glycogen storage disease type Ib (GSD-Ib), which is a metabolic and immune disorder. G6PT is a member of the Organophosphate:Pi antiporter (OPA)/SLC37 family, whose members are integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The OPA/SLC37 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340901 [Multi-domain] Cd Length: 409 Bit Score: 92.40 E-value: 2.78e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 16 RYLILLIIFIVTAVNYADRATLSIAGTEVAKELQLSAVSMGYIFSAFGWAYLLMQIPGGWLLDKFGSKKVYTYSLFFWSL 95
Cdd:cd17343 1 QLTIFASMFVGYTLYYFNRKSFSFVLPSLMNELGLDKSDLGLITSSQSLAYAISKFIGGVLSDQISARWLFSSGLVLSGL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 96 FTFLQGF---VDMFPLAWagismffmrFMLGFSEAPSFPANARIVAAWFPTKERGTASAIFNSAQYFSLALFSPLLGWLT 172
Cdd:cd17343 81 TTVAFSGsssVWVFSILW---------FLNGLAQGLGWPPCAKILRKWFSPSQFGTWWSVLSTSMNLAGSLGPILATLLA 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 173 FAWGWEHVFTVMGVIGFVLTALWIKLIHNptdhpRMSAEELKFISEngavvdmDHKKPGSAAASGPKLHyIKQLLSNRMM 252
Cdd:cd17343 152 LSYGWRSTLSISGTVAVVMSVVCLLFIKN-----EPSDVGLNNIEE-------EESKGKKKKSPRGEST-LKELLLSPFL 218
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 253 LGVFFGQYFINTITWFFLTWFPIYLVQEKGMSILKVGLVASIPALCGFAGGVLGGVFSDYLI-KRGLSLTLARKLPIVLG 331
Cdd:cd17343 219 WLLSLGYLVVFGVKTAVTDWGQLFLIQDKGQSALTGSSFMSSLEVGGFVGSIAAGYLSDWAVaKHGSSSRGNPRMPLALV 298
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 332 MLLASTIIL-------CNYTNNTTLVVMLMALAFFGKGFGALGWPVISDTAPKEIVGLCGGVFNVFGNVASIVTPLVIGY 404
Cdd:cd17343 299 FMAGLTVSLhlfrvhiTSDSSELFILLLGFLIGFSLYGPIAIFGVIANESAPSHLCGTSHAIVALAANVGGVLAGLPFSY 378
|
410 420 430
....*....|....*....|....*....|...
gi 1487549706 405 LVSElHSFNAALVFVGCSAlMAMVCYLFVVGDI 437
Cdd:cd17343 379 IAKH-YDWRTAFLLLEILC-AITVVILFLLRNI 409
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
15-433 |
1.45e-17 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 84.14 E-value: 1.45e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 15 TRYLILLIIFIVTAVNYADRATLSIAGTEVAKELQLSAVSMGYIFSAFGWAYLLMQIPGGWLLDKFGSKKVYTYSLFFWS 94
Cdd:COG0738 5 NYRRALIAIYLLFFLWGFATALWGPLIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMA 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 95 LFTFLQGFVDMFPlaWAGISMFFMRFMLGFSEApsfPANARIVAAwfptkERGTASAIFNSAQ-YFSL-ALFSPLLGWLT 172
Cdd:COG0738 85 LGLLLFALAPSYP--LLLLALFLLGLGLGLLDV---AANPYVAAL-----GPETAASRLNLLHaFFSLgALLGPLLGGLL 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 173 FAWG----WEHVFTVMGVIgFVLTALWIKLIHNPTDHPRMSAEELKFISengavvdmdhkkpgsaaasgpklhyIKQLLS 248
Cdd:COG0738 155 ILLGlslsWHLPYLILAVL-LLLLALLFLRSKLPEIEEEEEEAAGSAAS-------------------------LKSLLK 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 249 NRMMLGVFFGQYFINTITWFFLTWFPIYLVQEKGMSILKVGLVASIPALCGFAGGVLGGVFSDYlIKRGLSLTLArklpI 328
Cdd:COG0738 209 NPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKR-FGPVRLLRLS----A 283
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 329 VLGMLLASTIILcnytnntTLVVMLMALAFFGKGFG-ALGWPVI---SDTAPKEIVGLCGGVFNVFGNVASIVTPLVIGY 404
Cdd:COG0738 284 LLAAVGLLLALL-------APGPWLALIGLALVGLGlSLMFPTIfslALDGLGKRTAAAVSAVLIMGIVGGAIGPPLIGF 356
|
410 420
....*....|....*....|....*....
gi 1487549706 405 LvSELHSFNAALVFVGCSALMAMVCYLFV 433
Cdd:COG0738 357 L-ADAFGLRAAFLVPLVCYLLILLLALAL 384
|
|
| MFS_SLC17A5 |
cd17381 |
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of ... |
35-405 |
1.52e-17 |
|
Solute carrier family 17 member 5 (also called sialin) of the Major Facilitator Superfamily of transporters; Solute carrier family 17 member 5 (SLC17A5) is also called sialin, H(+)/nitrate cotransporter, H(+)/sialic acid cotransporter (AST), membrane glycoprotein HP59, or vesicular H(+)/aspartate-glutamate cotransporter. It transports glucuronic acid and free sialic acid out of the lysosome after its cleavage from sialoglycoconjugates, which is required for normal CNS myelination. It also mediates the membrane potential-dependent uptake of aspartate and glutamate into synaptic vesicles and synaptic-like microvesicles. In the plasma membrane, it functions as a nitrate transporter. Recessive mutations in the SLC17A5 gene cause the allelic disorders, Infantile sialic acid storage disease (ISSD) and Salla disease (a predominantly neurological disorder). SLC17A5 belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340939 [Multi-domain] Cd Length: 397 Bit Score: 84.06 E-value: 1.52e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 35 ATLSIAGTEVAKELQLSAVSMGYIFSAFGWAYLLMQIPGGWLLDKFGSKKVYTYSLFFWSLFTFLQGFVDMFPLAWagis 114
Cdd:cd17381 47 SSPSVEHNETGKKYDWDAETQGWILGSFFYGYIITQIPGGYLASKIGGKLLLGFGILGTAVFTLLTPLAADLGAGY---- 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 115 MFFMRFMLGFSEAPSFPANARIVAAWFPTKERGTASAIFNSAQYFSLALFSPLLGWLTFAWGWEHVFTVMGVIGFVLTAL 194
Cdd:cd17381 123 LIAVRALEGLGEGVTFPAMHAMWASWAPPLERSRLLTISYAGAQLGTVVSLPLSGLICYYLDWTYVFYIFGAVGLLWFFL 202
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 195 WIKLIHNptdhprmsaeelkfisengavvdmdhkkpgsaaasgpklhyikqllsnrmMLGVFFGQYFINTITWFFLTWFP 274
Cdd:cd17381 203 WIWLVMP--------------------------------------------------LWAIVVAHFSYNWTFYTLLTLLP 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 275 IYLVQEKGMSILKVGLVASIPALCGFAGGVLGGVFSDYLI-KRGLSLTLARKLPIVLGM------LLASTIILCNYtnnt 347
Cdd:cd17381 233 TYMKEILRFDIQENGFLSALPYLGCWLFMILSGQIADNLReKQNFSTVCVRKIFTLIGMigpavfLLAAGFTGCNY---- 308
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 1487549706 348 TLVVMLMALAFFGKGFGALGWPVIS-DTAPKeIVGLCGGVFNVFGNVASIVTPLVIGYL 405
Cdd:cd17381 309 SLAVAFLTISSTLGGFSASGFNINHlDIAPS-YAGILLGITNTFATIPGMVGPVIAKSL 366
|
|
| 2A0115 |
TIGR00895 |
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ... |
8-406 |
3.49e-17 |
|
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]
Pssm-ID: 273327 [Multi-domain] Cd Length: 398 Bit Score: 82.79 E-value: 3.49e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 8 EKKKGVHTRYLILLIIFIVTAVNYADRATLSIAGTEVAKELQLSAVSMGYIFSAFGWAYLLMQIPGGWLLDKFGSKKVYT 87
Cdd:TIGR00895 7 RKQPLSRYQWRAIILSFLIMLMDGYDLAAMGFAAPAISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLL 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 88 YSLFFWSLFTFLQGFvdmfplAWAGISMFFMRFMLGFSEAPSFPANARIVAAWFPTKERGTASAIFNSAQYFSLALFSPL 167
Cdd:TIGR00895 87 WSILLFSVFTLLCAL------ATNVTQLLILRFLAGLGLGGLMPNLNALVSEYAPKRFRGTAVGLMFCGYPIGAAVGGFL 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 168 LGWLTFAWGWEHVFTVMGVIGFVLTALWIKLIHNPTD-----HPRMSAEELKFISENgAVVDMDHKKPGSAAASGPKLHY 242
Cdd:TIGR00895 161 AGWLIPVFGWRSLFYVGGIAPLLLLLLLMRFLPESIDflvskRPETVRRIVNAIAPQ-MQAEAQSALPEQKSTQGTKRSV 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 243 IKQLLSNRMMLGVFF--GQYFINTITWFFLT-WFPiYLVQEKGMSILKVGLVASIPAlcgfAGGVLGGVFSDYLIKRgls 319
Cdd:TIGR00895 240 FKALFQGKTARITVLlwLLYFMLLVGVYFLTnWLP-KLMVELGFSLSLAATGGALFN----FGGVIGSIIFGWLADR--- 311
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 320 ltlARKLPIVLGMLLASTIILCNYTNNTTLVVMLMALAFFG--KGFGALGWPVIS-DTAPKEIVGLCGGVFNVFGNVASI 396
Cdd:TIGR00895 312 ---LGPRVTALLLLLGAVFAVLVGSTLFSPTLLLLLGAIAGffVNGGQSGLYALMaLFYPTAIRATGVGWAIGIGRLGAI 388
|
410
....*....|
gi 1487549706 397 VTPLVIGYLV 406
Cdd:TIGR00895 389 IGPILAGYLL 398
|
|
| MFS_MucK |
cd17371 |
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ... |
51-432 |
8.32e-17 |
|
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340929 [Multi-domain] Cd Length: 389 Bit Score: 81.58 E-value: 8.32e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 51 SAVSMGYIFSAFGWAYllmqipGGWLLDKFGSKKVYTYSLFFWSLFTFLQGFVDMFplawagISMFFMRFMLGFSEAPSF 130
Cdd:cd17371 38 LLGTVTLAGGAIGGIL------GGILADRFGRVRVLVITILLFAVFTLLCGFAQNY------WQLLILRALAGLGFGGEW 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 131 PANARIVAAWFPTKERGTASAIFNSAQY----FSLALFSPLLGWLTFAWGWEHVFtvmgVIGfVLTALWIKLIHNPTDHP 206
Cdd:cd17371 106 AAGAALMAEYVPARHRGKALGYVQSGWAvgwlLATLLAALLFPLLPPEIAWRVLF----LLG-ALPALLVLFIRRFVKEP 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 207 RMSAEelkfisengavvdmdHKKPGSAAASGPKLHYIKQLLSNRMMLGVFFGQYFINTITWFFLTWFPIYLVQEKGMSIL 286
Cdd:cd17371 181 PQWQA---------------ARAARRHFADRPSLRELFSPPLLRTTLLASLLATGALGGYYGITTWLPSYLTGERGLSFE 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 287 KVGLVASIPALCGFAGGVLGGVFSDYlikrglsltLARKLPIVLGMLLASTIILC--NYTNNTTLVVMLM-ALAFFGKG- 362
Cdd:cd17371 246 GSAGYLVVTILGGFLGYLAGGFLADR---------IGRRNNFALFALGSAISILLyfFLPLSPTLILILGfPLGFFASGp 316
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 363 FGALGwPVISDTAPKEIVGLCGGVFNVFGNVASIVTPLVIGYLVSELhSFNAALVFVGCSALMAMVCYLF 432
Cdd:cd17371 317 FSGMG-AYLTELFPTAVRATAQGFCYNVGRIIGALFPFLVGFLATSG-SLGTAIAVFAAVYYIAGLVLAL 384
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
42-431 |
9.80e-17 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 81.44 E-value: 9.80e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 42 TEVAKELQLSAVSMGYIFSAFGWAYLLMQIPGGWLLDKFGSKKVYTYSLFFWSLFTFLQGFvdmfplAWAGISMFFMRFM 121
Cdd:cd17324 23 PDIARDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAAL------APSFALLLLARAL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 122 LGFSEAPSFPANARIVAAWFPTKERGTASAIFNSAQYFSLALFSPLLGWLTFAWGWEHVFTVMGVIGFVLTALWIKLIhn 201
Cdd:cd17324 97 AGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWRLL-- 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 202 ptdhPRMsaeelkfisengavvdmdhkkPGSAAASGPKLHYIKQLLSNRMMLGVFFGQYFINTITWFFLTWFPIYLVQEK 281
Cdd:cd17324 175 ----PSL---------------------PPKKPGSLGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVP 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 282 GMSILKVGLVASIPALCGFAGGVLGGVFSDYLikrglsltLARKLPIVLGMLLASTIILCNYTNNTTLVVMLMALAFFGK 361
Cdd:cd17324 230 GFSSSAIIGLLLLFGVAGVVGSPLAGRLADRG--------GRRALLIALLLLAAALLLLTLLGPSPLLLLVGLVLWGLGF 301
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 362 GFGALGWPVISDTAPKEIVGLCGGVFNVFGNVASIVTPLVIGYLVSELhSFNAALVFVGCSALMAMVCYL 431
Cdd:cd17324 302 FAAHSALQTRVLRLAPEARGLASSLYLAAYNLGGALGAALGGLVLDHG-GWAGVGWVGAALLLLALLLAL 370
|
|
| MFS_SLC17A6_7_8_VGluT |
cd17382 |
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of ... |
56-405 |
2.21e-16 |
|
Solute carrier family 17 members 6, 7, and 8 (also called Vesicular glutamate transporters) of the Major Facilitator Superfamily of transporters; This subfamily is composed of solute carrier family 17 member 6 (SLC17A6), SLC17A7, SLC17A8, and similar proteins. SLC17A6 is also called vesicular glutamate transporter 2 (VGluT2), differentiation-associated BNPI, or differentiation-associated Na(+)-dependent inorganic phosphate cotransporter. SLC17A7 is also called VGluT1 or brain-specific Na(+)-dependent inorganic phosphate cotransporter. SLC17A8 is also called VGluT3. They mediate the uptake of glutamate into synaptic vesicles at presynaptic nerve terminals of excitatory neural cells, and may also mediate the transport of inorganic phosphate. VGluTs are also expressed and localized in various secretory vesicles in non-neuronal peripheral organelles such as hormone-containing secretory granules in endocrine cells, and thus, also act as metabolic regulators. The VGluT subfamily belongs to the Solute carrier 17 (SLC17) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340940 [Multi-domain] Cd Length: 380 Bit Score: 80.46 E-value: 2.21e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 56 GYIFSAFGWAYLLMQIPGGWLLDKFGSKKVYTYSLFFWSLFTFLqgfvdmFPLA--WAGISMFFMRFMLGFSEAPSFPAN 133
Cdd:cd17382 52 GLIESSFFWGYLVTQIPGGFIAAKFAANRVFGLAIFVTSTLNML------IPIAarVHYGCVIFVRILQGLVEGVTYPAC 125
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 134 ARIVAAWFPTKERGTASAIFNSAQYFSLALFSPLLGWLTFAWGWEHVFTVMGVIGFVLTALWIKLihnptdhprmsaeel 213
Cdd:cd17382 126 HGIWRKWAPPLERSRLATTAFCGSYAGAVVGMPLSGILVQYVGWSSPFYVYGVFGIIWYMFWMLV--------------- 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 214 kfisengavvdmdhkkpgsaaaSGPKLHYIkqlLSNrmmlgvffgqyFINTITWFFLTWF-PIYLVQEKGMSILKVGLVA 292
Cdd:cd17382 191 ----------------------SMPVYAII---VAN-----------FCRSWTFYLLLISqPAYFKEVFGFDISKVGILS 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 293 SIPALCGFAGGVLGGVFSDYLIKRG-LSLTLARKLPIVLGMLLASTIILC-NYTNNTTLVVMLMALAFFGKGFGALGWPV 370
Cdd:cd17382 235 ALPHLVMTIIVPIGGQLADYLRSRGiLSTTAVRKIFNCGGFGMEATFLLVvAFSHSPTVAISFLVLAVGFSGFAISGFNV 314
|
330 340 350
....*....|....*....|....*....|....*.
gi 1487549706 371 IS-DTAPKeIVGLCGGVFNVFGNVASIVTPLVIGYL 405
Cdd:cd17382 315 NHlDIAPR-YASILMGISNGIGTLSGMVCPVIVGAL 349
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
42-433 |
1.18e-15 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 78.00 E-value: 1.18e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 42 TEVAKELQLSAVSMGYIFSAFGWAYLLMQIPGGWLLDKFGSKKVYTYSLFFWSLFTFLQGFVDMFPLawagisMFFMRFM 121
Cdd:cd17474 23 PAIAEALGASPAQVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFAL------LLAGRAL 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 122 LGFSEAPSFPANARIVAAWFPTKERGTASAIFNSAQYFSLALfSPLLGWLTFAWGWEHVFTVMGVIGFVLTALWIKLIHN 201
Cdd:cd17474 97 QGIGAAGLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAV-GPLLGGLLAAISWRYPFFLLAALIPVAFLAILFLLPE 175
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 202 PTDHPRMSAEELKFISengavvdmdhkkpgsaaasgpklhyiKQLLSNRMMLGVFFGQYFINTITWFFLTWFPIYLVQEK 281
Cdd:cd17474 176 PKEKAKSSSATKLRDL--------------------------KKALRGRGLLTFLVSAFLYFFLYFAFLTYLPFLLELLY 229
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 282 GMSILKVGLVASIPALcgfaGGVLGGVFSDYLIKRGLSltlarKLPIVLGMLLASTIILCNYTNNTTLVVMLMALAFFGK 361
Cdd:cd17474 230 GISPIIIGLLFAGWSV----LLALGSLFVGRLLKKRFG-----ARRILVIGLLLYALSLLLLGFVPSLALLLIAIVLFGL 300
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1487549706 362 GFGaLGWPVISDT----APKEIVGLCGGVFNVFGNVASIVTPLVIGYLvSELHSFNAALVFVGCSALMAMVCYLFV 433
Cdd:cd17474 301 GLG-LNLPLLTTLvtelAPEEERGTASSLYNFVRFLGQAVGPLLFGLL-LEIFGLSAPFLVGAAIALAAAVLLALL 374
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
1-433 |
1.42e-15 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 77.99 E-value: 1.42e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 1 MILDTVDEKKKGVHTRYLILLIIFIVTAVNYADRATLSIAGTEVAKELQLSAVSMGYIFSAFGWAYLLMQIPGGWLLDKF 80
Cdd:COG2807 1 MSTTSSSARRSRRAGRWLLLLAIVLVALNLRPAITSVGPLLPEIRADLGLSATQAGLLTTLPLLAFGLFAPLAPRLARRF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 81 GSKKVYTYSLFFWSLFTFLQGFVDMFPLAWAGismffmRFMLGFSEAPSFPANARIVAAWFPTKeRGTASAIFNSAQYFS 160
Cdd:COG2807 81 GLERTLLLALLLLAAGLLLRSLAPSVALLLAG------TALIGAGIAVGNVLLPGLIKRWFPDR-VGLMTGLYTAAMGLG 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 161 LALFSPLLGWLTFAWGWEHVFTVMGVIGFVLTALWIKLIHNptdhprmsaeelkfisengavvdmdHKKPGSAAASGPKL 240
Cdd:COG2807 154 AALAAGLTVPLAAALGWRGALAVWALLALLALLLWLPLLRR-------------------------RPAAAAAAPAAASL 208
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 241 hyiKQLLSNRM--MLGVFFGqyFINTITWFFLTWFPIYLvQEKGMSILKVGLVASIPALCGFAGGVLGGVFSDYlikrgl 318
Cdd:COG2807 209 ---RSLWRSPLawLLTLFFG--LQSLLYYAVVAWLPPIL-RDAGLSAATAGLLLSLFQLAGIPGSLLVPLLADR------ 276
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 319 sltLARKLPIVLGMLLASTIILCNYTNNTTLVVMLMALaFFGKGFGA---LGWPVISDTAP-KEIVGLCGGVFNVFGNVA 394
Cdd:COG2807 277 ---LGDRRPLLLLLGLLGLAGLLGLLLAPGSLPWLWAV-LLGLGQGGlfpLALTLIGLRARtPAEAAALSGMAQSVGYLL 352
|
410 420 430
....*....|....*....|....*....|....*....
gi 1487549706 395 SIVTPLVIGYLVSELHSFNAALVFVGCSALMAMVCYLFV 433
Cdd:COG2807 353 AALGPLLVGALHDATGSWTAALLLLAALAVLMLVAGLLA 391
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
16-198 |
7.99e-15 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 74.85 E-value: 7.99e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 16 RYLILLIIFIVTAVNYADRATLSIAGTEVAKELQLSAVSMGYIFSAFGWAYLLMQIPGGWLLDKFGSKKVYTYSLFFWSL 95
Cdd:COG0477 12 RRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGL 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 96 FTFLQGfvdmfpLAWAGISMFFMRFMLGFSEAPSFPANARIVAAWFPTKERGTASAIFNSAQYFSLALFSPLLGWLTFAW 175
Cdd:COG0477 92 ASLLCG------LAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGLLVAAL 165
|
170 180
....*....|....*....|...
gi 1487549706 176 GWEHVFTVMGVIGFVLTALWIKL 198
Cdd:COG0477 166 GWRWIFLINAPLGLLALVLRLRL 188
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
18-199 |
2.07e-13 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 71.45 E-value: 2.07e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 18 LILLIIFIVTAVNYADRATLSIAGTEVakeLQLSAVSMGYIFSAFGWAYLLMQIPGGWLLDKFGSKKVYTYSLFFWSLFT 97
Cdd:cd17325 203 ALFLAIFVLAFAFGALEPFLPLYAAEL---GGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAVAL 279
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 98 FLQGFVDMFPLAWAGIsmffmrFMLGFSEAPSFPANARIVAAWFPTKERGTASAIFNSAQYFSLALFSPLLGWLTFAWGW 177
Cdd:cd17325 280 LLLPLATSFWLLLLLL------ALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGF 353
|
170 180
....*....|....*....|..
gi 1487549706 178 EHVFTVMGVIGFVLTALWIKLI 199
Cdd:cd17325 354 ATPFLAAAALLLLAAVLFLLLR 375
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
74-433 |
2.20e-13 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 71.07 E-value: 2.20e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 74 GWLLDKFGSKKVYTYSLFFWSLFTFLQGFVDMFPLawagisMFFMRFMLGFSEAPSFPANARIVAAWFPTKERGTASAIF 153
Cdd:cd17473 56 GWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYA------LLASRALLGIGVAGIMTLATALIGDYFEGEERAKMLGLQ 129
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 154 NSAQYFSLALFSPLLGWLTfAWGWEHVFTVMGViGFVLTALWIKLIHNPTDHPRMSAEELKfisengavvdmdhkkpgsa 233
Cdd:cd17473 130 SAAMSLGGVVFLLLGGALA-EIGWRAPFLVYLL-ALPVLILVLLFLPEPARKSKSAASPGA------------------- 188
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 234 aasgpklhYIKQLLSNRMMLGVFFGQYFINTITWFFLTWFPIYLVQEKGMSILKVGLVASIPALcgfaGGVLGGVFSDYL 313
Cdd:cd17473 189 --------ATAAALPWKRVLPIYFLAFLAMLLFYVIPIQLPFLLQERGGGSAALIGLALAIASL----AGAIGALLFGRL 256
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 314 IKRglsLTLARKLPIVLGmLLASTIILCNYTNNttLVVMLMALAFFGKGFGALGWPV---ISDTAPKEIVGLCGGVFNVF 390
Cdd:cd17473 257 KRR---LGKRRLLAIGFA-LMALGFLLLALASG--LWVVLLGAILAGLGFGLLLPTLnswAMSLVPPELRGRAMGIVTSA 330
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 1487549706 391 GNVASIVTPLVIGYLVSELHSFNAALVFVGCSALMAMVCYLFV 433
Cdd:cd17473 331 FFLGQFLSPLVLGPLVNLTGGLSGAFLILGVLALVLAIVLLLL 373
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
33-397 |
2.89e-12 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 67.58 E-value: 2.89e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 33 DRATLSIAGTEVAKELQLSAVSMGYIFSAFGWAYLLMQIPGGWLLDKFGSKKVYTYSLFFWSLFTFLQGFvdmfplAWAG 112
Cdd:cd17321 11 DVTIVNVALPTIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCAL------APSL 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 113 ISMFFMRFMLGFSEAPSFPANARIVAAWFPTKERGTASAIFNSAQYFSLALFSPLLGWLTFAWGWEHVFTVMGVIGFVLT 192
Cdd:cd17321 85 AFLIAARALQGIGAAAIMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIGLVAL 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 193 ALwiklihnptdhprmsaeelkfisengavvdmdhkkpgsaaasgpklhyikqllsNRMMLGVFFGQYFINTITWFFLTW 272
Cdd:cd17321 165 LL------------------------------------------------------ARTFSGAVLAAFLLGAALGGLLFL 190
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 273 FPIYLVQEKGMSILKVGLVASIPALCGFAGGVLGGVFSDYLIKRglsltlarkLPIVLGMLL--ASTIILCNYTNNTTLV 350
Cdd:cd17321 191 LPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGPR---------LVLVAGLLLtaVGLLLLALLGADSSVW 261
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|
gi 1487549706 351 VMLMALAFFGKGFGALGWP---VISDTAPKEIVGLCGGVFNVFGNVASIV 397
Cdd:cd17321 262 LLLPGLVLLGLGLGLFATPltnAALSSVPKEKAGAASGILNTARQLGGAL 311
|
|
| MFS_YcxA_like |
cd17355 |
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ... |
50-428 |
3.17e-12 |
|
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340913 [Multi-domain] Cd Length: 386 Bit Score: 67.68 E-value: 3.17e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 50 LSAVSMGYIFSAFGWAylLMQIPGGWLLDKFGSKKVYTYSLFFWSLFTFLQGFVD---MFPLAWAGIsmffmrfMLGFSE 126
Cdd:cd17355 37 RAVISLAFTVGLLAFG--LAQPFVGRLLDRFGPRRVMLLGLLLLAAGLVLLALATslwQLYLLWGLL-------GGGGAG 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 127 APSFPANARIVAAWFPTKeRGTASAIFNSAQYFSLALFSPLLGWLTFAWGWEHVFTVMGVIGFVLTALWIKLIHNPTdhp 206
Cdd:cd17355 108 TLAAVAFATVAAWWFERR-RGLALGILTAGGGLGSLVFLPLGAALIEAFGWRTALLVLALLALLVLVPVLLLLRRRP--- 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 207 rmsaeelkfiSENGAVVDMDHKKPGSAaasgpklHYIKQLLSNRMMLGVFFGQYFINTITWFFLTWFPIYLVqEKGMSIL 286
Cdd:cd17355 184 ----------ADLALRAYDDASPASPG-------STLKEALRSASFWLLALAFFLCGFAVVGLIVHLVPYLA-DRGISPA 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 287 KVGLVASIPALCGFAGGVLGGVFSDYLIKRglsltlaRKLPIVLGMLLASTIILCNYTnnTTLVVMLMALAFFGKGFGAL 366
Cdd:cd17355 246 AAAVALALIGLFNIVGRLLSGWLGDRYSPR-------RLLAASYALRALGLALLLLLP--FPPLALLLFAALFGLGWGAT 316
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1487549706 367 GWPV---ISDTAPKEIVGLCGGVFNVFGNVASIVTPLVIGYLVSELHSFNAALVFVGCSALMAMV 428
Cdd:cd17355 317 VPLTaalAARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTGSYTAAWALAVALGLIAAL 381
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
19-434 |
2.95e-11 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 64.54 E-value: 2.95e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 19 ILLIIFIVTAVNYADRATLSIAgtevAKELQLSAVSMGYIFSAFGWAYLLMQIPGGWLLDKFGSKKVYTYSLFFWSLFTF 98
Cdd:cd17489 1 ILLANFFFFLSFYLLLPVLPLY----AHDLGGSEAVAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 99 LQGFVDMFPLawagisMFFMRFMLGFSEAPSFPANARIVAAWFPTKERGTASAIFNSAQYFSLALFSPLLGWLTFAWGWE 178
Cdd:cd17489 77 LYLLATSVAL------LLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFA 150
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 179 HVFTVMGVIGFVLTALWIKLihnPTDHPRMSAEELKFISENGAVVDMdhkkpgsaaasgpklhyiKQLLSNRMMLGVFFG 258
Cdd:cd17489 151 VLFIVAAVLALLALLLVFLV---KDPPPVAAEEAEAGTRAFRRLVEK------------------KVLPPALILFLASIA 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 259 QYFIntitwffLTWFPIYlVQEKGMSilKVGLVASIPALCGFAGGVLGGVFSDylikrglslTLARKLPIVLGMLLASTI 338
Cdd:cd17489 210 YGAI-------STFLPLY-AAERGIS--NAGLFFTVYAIALLLSRPFSGKLSD---------RKGPKTVIIPGLLLLALG 270
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 339 ILCnYTNNTTLVVMLMALAFFGKGFGAL---GWPVISDTAPKEIVGLCGGVFNVFGNVASIVTPLVIGyLVSELHSFNAA 415
Cdd:cd17489 271 LLL-LSFAGSPWMLLLAAVLYGLGFGLLfpaLQALAVDLVPPHRRGAANGTFFIFFDLGIGLGGLLLG-LVAELFGYRAM 348
|
410
....*....|....*....
gi 1487549706 416 LVFVGCSALMAMVCYLFVV 434
Cdd:cd17489 349 FLLAAVVVLLALVLYIFLL 367
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
45-431 |
4.33e-10 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 61.03 E-value: 4.33e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 45 AKELQLSAVSMGYIFSAFGWAYLLMQIPGGWLLDKFGSKKVYTYSLFFWSLFTFLQGFVDMFPLawagisMFFMRFMLGF 124
Cdd:cd17478 23 IAKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWL------LLLLVALAGI 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 125 SEAPSFPANARIVAAwFPTKERGTASAIFNSAQYFSLALfSPLLGWLTFAWGWEHVFTVMGVIGFVLTALWIKLIHNPTD 204
Cdd:cd17478 97 GSAAFHPEGARLASQ-AAGGRRGLAMSIFSVGGNLGFAL-GPLIAAALVALFGGLGLLILLIIPGLAVALLLLRLRPLKK 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 205 HPRmsaeelkfisengavvdmdHKKPGSAAASGPKLHYIKQLLsnrMMLGVFFGQYFINTItwfFLTWFPIYLVQeKGMS 284
Cdd:cd17478 175 PEA-------------------KKAAAKSSARSTLKGVWRALL---LLLIIVFLRSWVLSS---LTTFLPFYLVQ-RGYS 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 285 ILKVGLVASIPALCGFAGGVLGGVFSDYlikrglsltLARKLPIVLGMLLAS-TIILCNYTNNTTLVVMLMALAFFGKGF 363
Cdd:cd17478 229 LVFAGLLLSLFLFAGAIGTLIGGPLSDR---------FGRRRVIIASLLLAApFLLLFLLTPGIWSYILLVLAGFLLFAS 299
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1487549706 364 GALGwPVISDTAPKEIVGLCGGVFNVFGNVASIVTPLVIGYLvSELHSFNAALVFVGCSALMAMVCYL 431
Cdd:cd17478 300 FPVT-VVLAQELLPGNVGLASGLMMGLSFGLGGIGAPVLGAL-ADAFGLESVLLILALLPLLGALLAF 365
|
|
| PRK11551 |
PRK11551 |
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional |
18-407 |
1.15e-09 |
|
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
Pssm-ID: 236927 [Multi-domain] Cd Length: 406 Bit Score: 59.98 E-value: 1.15e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 18 LILLIIFIVTAVNYADRATLSIAGTEVAKELQLSAVSMGYIFSAFGWAYLLMQIPGGWLLDKFGSKKVYTYSLFFWSLFT 97
Cdd:PRK11551 15 LTIGLCFLVALLEGLDLQSAGVAAPRMAQEFGLDVAQMGWAFSAGILGLLPGALLGGRLADRIGRKRILIVSVALFGLFS 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 98 FLQGFVDMFPlawagiSMFFMRFMLGFSEAPSFPANARIVAAWFPTKERGTASAIFNSAQYFSLALFSPLLGWLTFAWGW 177
Cdd:PRK11551 95 LATAQAWDFP------SLLVARLLTGVGLGGALPNLIALTSEAVGPRLRGTAVSLMYCGVPFGGALASVIGVLAAGDAAW 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 178 EHVFTVMGVIGFVLTALWIKLIHNPTDHPRMSAEELKFISENGAVVdmdhkKPGSAAASgpklhyikqllsnrmmLGVFF 257
Cdd:PRK11551 169 RHIFYVGGVGPLLLVPLLMRWLPESRAFAQAAGAGKQRAPVLRALF-----GEGRATAT----------------LLLWI 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 258 GQYFINTITWFFLTWFPIYLVqEKGMSILKVGLVASIPALCGFAGGVLGGVFSDYLikrglsltlaRKLPIVLGMLLAST 337
Cdd:PRK11551 228 SYFFTLIVLYFLLNWLPSLLV-GQGLSRSQAGLVQIAFNIGGALGSLLIGALMDRL----------RPRRVVLLIYAGIL 296
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1487549706 338 IILCNYTNNTTLVvmLMALAFFGKGFGALG-----WPVISDTAPKEIVGLCGGVFNVFGNVASIVTPLVIGYLVS 407
Cdd:PRK11551 297 ASLAALAAAPSFA--GMLLAGFAAGLFVVGgqsvlYALAPLFYPTQVRGTGVGAAVAVGRLGSMAGPLLAGQLLA 369
|
|
| MFS_NRT2_like |
cd17341 |
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major ... |
37-434 |
1.84e-09 |
|
Plant Nitrate transporter NRT2 family and Bacterial Nitrate/Nitrite transporters of the Major Facilitator Superfamily; This family is composed of plant NRT2 family high-affinity nitrate transporters as well as nitrate and nitrite transporters from bacteria including Bacillus subtilis nitrate transporter NasA and nitrite extrusion protein NarK, Staphylococcus aureus NarT, Synechococcus sp. nitrate permease NapA, Mycobacterium tuberculosis NarK2 and nitrite extrusion protein NarU. NRT2 family proteins are involved in the uptake of nitrate by plant roots from the soil through the high-affinity transport system (HATS). There are seven Arabidopsis thaliana NRT2 proteins, called AtNRT2:1 to AtNRT2:7. The NRT2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340899 [Multi-domain] Cd Length: 384 Bit Score: 59.19 E-value: 1.84e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 37 LSIAGTEVAKELQLSAVSMGYIFSAFGWAYLLMQIPGGWLLDKFGSKKVYTYSLFFWSLFTFLQGFVdMFPLAWagisMF 116
Cdd:cd17341 18 FAPLGPVIRDDLGLSTSQIGLLVAIPVLAGALLRLPYGFLCDRFGGRRVFIASLLLLLIPLLALALA-VSSYWG----LL 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 117 FMRFMLGFSEApSFPANARIVAAWFPTKERGTASAIF-------NSAQYFSLALFSPLLGWLTFAWGWEHVFTVMG---V 186
Cdd:cd17341 93 VLGFLLGFAGA-NFASGQPWASFWFPKEKIGGAAGGIagagnmgVAVSQLLAPLIAGAIVFDGGFVGWRNAFFVPGillA 171
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 187 IGFVLTALWIKlihnptdhprmsaeelkfisengavvDMDHKKPGSAAASGPKLHYIKQLLSNRMML--GVFFGQYFInt 264
Cdd:cd17341 172 IAAVLVLLFGD--------------------------DLPTGKASALEFLKVQLAVLKNYRTWILSLlyGVTFGSFVG-- 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 265 itwfFLTWFPIYLVQEKGMSILKVGLVASIPALCGFAGGVLGGVFSDYLIKRGLSLTLArKLPIVLGMLLASTIILCNYT 344
Cdd:cd17341 224 ----FSNVLPTYFKTRFGLPLVTAGILAALFPLAGALARPAGGWLSDRFGGRRRLWWLF-IVMTIGAALLSLSLPTSGTN 298
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 345 NNTTLVVMLMALAFFGKGFGALG--WPVISdtapKEIVGLCGGVFNVFGNVASIVTPLVIGYLVSELHSFNAALVFVGcs 422
Cdd:cd17341 299 LVLFLALFVALGLGAGAGNGSVFrmVPFIF----RRELGAVTGLVGAIGGLGGFFLPLLFGSSALMTGSGVGAFSLFG-- 372
|
410
....*....|..
gi 1487549706 423 aLMAMVCYLFVV 434
Cdd:cd17341 373 -VLAVACTLLVW 383
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
47-407 |
1.92e-09 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 59.53 E-value: 1.92e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 47 ELQLSAVSMGYIFSAFGWAYLLMQIPGGWLLD----KFGSKKVY------TYSLFFWSLFTFlQGFVDMFPLAWAGISMF 116
Cdd:COG2211 40 VLGLSAALVGLILLVARLWDAITDPLIGALSDrtrtRWGRRRPWiligaiPLALSFVLLFTA-PDLSPTGKLIYALVTYL 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 117 FMRFMLGFSEAPSFPANARIVAawfPTKERGTASAIFNSAQYFSLALFSPLLGWLTFAW------GWEHVFTVMGVIGFV 190
Cdd:COG2211 119 LLGLAYTLVNIPYSALGAELTP---DYEERTRLSSWRFAFAGLGGLLASVLPPPLVAAFggdaalGYRLTALIFAVLGLL 195
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 191 LTALWIKLIHnptdhprmsaeelkfisengavvdmdhKKPGSAAASGPKLHYIKQLLSNRMMLGVFFGQYFINTITWFFL 270
Cdd:COG2211 196 AFLLTFFGTK---------------------------ERPVPEEEKVSLKESLKALLKNRPFLLLLLAYLLFFLALALVA 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 271 TWFPIYLVQEKGMSILKVGLVASIPALCGFAGGVLGGVFSDYLIKRGLsltlarklpIVLGMLLASTIILCNY---TNNT 347
Cdd:COG2211 249 ALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKA---------FIIGLLLAALGLLLLFflgPGNL 319
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1487549706 348 TLVVMLMALAFFGKG-FGALGWPVISDTAP-------KEIVGLCGGVFNVFGNVASIVTPLVIGYLVS 407
Cdd:COG2211 320 WLLLVLAALAGIGLGaILVLPWAMLADVVDydewktgRRREGLYFGIFTFAIKLGQALAGALAGLLLA 387
|
|
| PRK12382 |
PRK12382 |
putative transporter; Provisional |
56-197 |
2.14e-09 |
|
putative transporter; Provisional
Pssm-ID: 183487 [Multi-domain] Cd Length: 392 Bit Score: 58.92 E-value: 2.14e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 56 GYIFSAFGWAYLLMQIPGGWLLDKFGSKKVYTYSLFFWSLFTFLQGFVDMFPLAWAGISMffmrfmLGFSEAPSFPANAR 135
Cdd:PRK12382 252 GFTLTAFGGAFVLMRVLFGWMPDRFGGVKVAIVSLLVETVGLLLLWLAPTAWVALAGAAL------TGAGCSLIFPALGV 325
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1487549706 136 IVAAWFPTKERGTASAIFNSAQYFSLALFSPLLGWLTFAWGWEHVF---TVMGVIGFVLTALWIK 197
Cdd:PRK12382 326 EVVKRVPSQVRGTALGGYAAFQDIAYGVSGPLAGMLATSFGYPSVFlagAISAVLGIIVTILSFR 390
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
44-425 |
7.72e-09 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 57.24 E-value: 7.72e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 44 VAKELQLSAVSMGYIFSAFGWAYLLMQIPGGWLLDKFGSKKVYTYSLFFWSLFTFLQGFVDMFPLAWAGIsmffmrFMLG 123
Cdd:cd17329 26 LHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIAL------VLTG 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 124 FSEAPSFPANARIVAAWFPTKERGTASAIFNSAQYFSLALfSPLLGWLTFAWGWEHVFTVmGVIGFVLTALWIKLIHNPT 203
Cdd:cd17329 100 FGGGLFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAI-GPLLGGLLLLYSFRLLFLA-AAVLFLLAALVLLFLLPET 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 204 DHPRMSAEELKFISEngavvdmdhkkpgsaaasgpklhyIKQLLSNRMMLGVFFGQYFINTITWFFLTWFPIYLVQEKGM 283
Cdd:cd17329 178 RPKRRAAEKTEILRG------------------------YKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGL 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 284 SILKVGLVASIPALCGFAGGvlggvfsdYLIKRGLSLTLARKLpIVLGMLLASTIILCnYTNNTTLVVMLMALAFFGKGf 363
Cdd:cd17329 234 GESLLGLLLALNALLIVLLQ--------FPVARLVERFRLRKI-LMIGILLFAIGFAV-LAFANTLAVLILAMIVLTLG- 302
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1487549706 364 GALGWP----VISDTAPKEIVGLCGGVFNVFGNVASIVTPLVIGYLVSelhSFNAALVFVGCSALM 425
Cdd:cd17329 303 EMLVFPavqtLVAALAPPDKRGSYMGFYALAWGLGRAIGPLVGGLLLD---LLGPGLPWLILAALG 365
|
|
| MFS_UhpC |
cd17488 |
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane ... |
16-315 |
8.24e-09 |
|
Membrane sensor protein UhpC of the Major Facilitator Superfamily of transporters; Membrane sensor protein UhpC acts as both a sensor and a transport protein. It is part of the UhpABC signaling cascade that controls the expression of the hexose phosphate transporter UhpT. UhpC recognizes external glucose-6-phosphate (Glc6P) and induces transport by UhpT. It can also transport and sense Glc6P, and interacts with the histidine kinase UhpB, leading to the stimulation of the autokinase activity of UhpB. This group also includes the hexose phosphate transport protein UhpT from Chlamydia pneumoniae; it is a transport protein for sugar phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The UhpC group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341041 [Multi-domain] Cd Length: 364 Bit Score: 57.03 E-value: 8.24e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 16 RYLILLIIFIVTAVNYADRATLSIAGTEVAKELQLSAVSMGYIFSAFGWAYLLMQIPGGWLLDKFGSKKVYTYSLFFWSL 95
Cdd:cd17488 1 RIHILASMFIGYAVFYLTRKSFNAAMPAMLADLGLDKSDIGILGSLFYITYGVSKFVSGLMSDRSNPRYFMGIGLIATGI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 96 FTFLQGFVDmfplawaGISMFFMRFML-GFSEAPSFPANARIVAAWFPTKERGTASAIFNSAQYFSLALFSPLLGWLTFA 174
Cdd:cd17488 81 INILFGFSS-------SLWAFAVLWTLnAFFQGWGWPPCARLLTHWYSRNERGFWWSIWNTSHNIGGALIPILTGFAALT 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 175 WGWEHVFTVMGVIGFVLTalwIKLIHNPTDHPRmsaeelkfisengavvdmdhkkpgsaaasgpklhYIKQLLSNRMMlg 254
Cdd:cd17488 154 YGWRAGMYVPGIIAILMG---IVLCWRLRDRPP----------------------------------YIWLLAFCYVL-- 194
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1487549706 255 VFFGQYFINtitwfflTWFPIYLVQEKGMSILKVGLVASIPALCGFAGGVLGGVFSDYLIK 315
Cdd:cd17488 195 VYVVRTAIN-------DWGNLYLSETHGYSLVKANSAVSLFEVGGLIGALVAGWGSDKLFK 248
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
37-194 |
8.93e-09 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 57.20 E-value: 8.93e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 37 LSIAGTEVAKELQLSAVSMGYIFSAFGWAYLLMQIPGGWLLDKFGSKKVYTYSLFFWSLFTFLQGfvdmfpLAWAGISMF 116
Cdd:cd17503 15 VNVALPTIMGDLGASLDTVQWVITSYLLALAIMIPLSGWLADRFGTRRLFLTALALFTLGSLLCG------LAPNLASLI 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 117 FMRFMLGFSEAPSFPANARIVAAWFPTKERGTASAIFNSAQYFSLALFSPLLGWLTFAWGWEHVFTV---MGVIGFVLTA 193
Cdd:cd17503 89 IFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYInlpIGILALLLAP 168
|
.
gi 1487549706 194 L 194
Cdd:cd17503 169 L 169
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
18-198 |
1.82e-08 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 56.08 E-value: 1.82e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 18 LILLIIFIVTAVNYADRATLSIAGTEVAKELQLSAVSMGYIFSAFGWAYLLMQIPGGWLLDKFGSKKVYTYSLFFWSLFT 97
Cdd:cd06173 209 LLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLAL 288
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 98 FLQGFVDMFPLawagisMFFMRFMLGFSEAPSFPANARIVAAWFPTKERGTASAIFNSAQYFSLALFSPLLGWLTFAWGW 177
Cdd:cd06173 289 LVLGLSPSLWL------LLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGL 362
|
170 180
....*....|....*....|.
gi 1487549706 178 EHVFTVMGVIGFVLTALWIKL 198
Cdd:cd06173 363 SAVFLLAGALLLLAALLLLLL 383
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
38-433 |
9.10e-08 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 53.77 E-value: 9.10e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 38 SIAGTEVAKELQLSAVSMGYIFSAFGWAYLLMQIPGGWLLDKFGSKKVYTYSLFFWSLFTFLQGFVDMFPLAWagismFF 117
Cdd:cd17353 23 SVFNPPLSSALGWSLASVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFGLGFILSAFAISLPLLF-----LG 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 118 MRFMLGFSEAPSFPANARIVAAWFPTKeRGTASAIFNSAQYFSLALFSPLLGWLTFAWGWEHVFTVMGVIGFVLTALWIK 197
Cdd:cd17353 98 YGVLGGIGAGIGYITPVSTAVKWFPDK-RGLATGIVIAGFGLGSLIFSPLIAYLINTVGVPTTFLILGIIFLIIIVIGAF 176
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 198 LIHNPtdhPRMSAEELKFISENGAVVDMDHKKPGSAAASGpklHYIKQLLSnrMMLGVFFGQYFINTItwffltwfPIYL 277
Cdd:cd17353 177 LIRDP---PKGWVPPGVDPLANNAENSPRDYTPREMLRTP---TFWLLWLM--FFLNATAGLMLIGQA--------KPIG 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 278 VQEKGMSILKVGLVASIPALCGFAGGVLGGVFSDYlIKRGLSLTlarklpIVLGMLLASTIILCNYTNNTTLVVMLMALA 357
Cdd:cd17353 241 QEFAGLDAGIAALAVSILSIFNGGGRPFWGWLSDK-IGRKNTLS------IAFLIQGVAMFLLPFIGSVAVLFVLGVALI 313
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1487549706 358 FFGKGFGALGWPVI-SDTAPKEIVGLCGGVFNVFGNVASIVTPLVIGYLVSElHSFNAALVFVGCSALMAMVCYLFV 433
Cdd:cd17353 314 GFCYGGGFALFPALtADFFGTKNAGTNYGLLYTAKGVGGLIGPIIAAYVLYT-GGYNAAFIIAAALSLVALALALLL 389
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
45-432 |
1.80e-07 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 53.00 E-value: 1.80e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 45 AKELQLSAVSMGYIFSAFGWAYLLMQIPGGWLLDKFGSKKV--YTYSLFFWSLFTFLQGFVDMFPLAWAgisMFFMRFML 122
Cdd:cd06173 26 VLQLTGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLliLADLLRALLAAVLALLALLGSLSLWL---LLVLAFLL 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 123 GFSEAPSFPANARIVAAWFPTKERGTASAIFNSAQYFSlALFSPLLGWLTFAWGWEHVFTVMGVIGFVLTALWIKLIHNP 202
Cdd:cd06173 103 GIASAFFGPARQALLPELVPKEQLVRANALNSLATQLA-RIIGPALGGLLVALLGPGGAFAINALSFLLSALLLLFIRRP 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 203 TDHPRmsaeelkfisengavvdmdhkKPGSAAASGPKLHYIKQLLSNRMMLGVFFGQYFINTITWFFLTWFPIYLVQEKG 282
Cdd:cd06173 182 PPAAP---------------------GESSSLLLRDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLG 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 283 MSILKVGLVASIPALCGFAGGVLGGVFSDYLIKRGLsltlarkLPIVLGMLLASTIILCNYTNNTTLVVMLMALAFFGKG 362
Cdd:cd06173 241 GGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRL-------LLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGL 313
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 363 FGALGWPVISDTAPKEIVGLCGGVFNVFGNVASIVTPLVIGYLVSELHSFNAALVFVGCSALMAMVCYLF 432
Cdd:cd06173 314 FNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGALLLLAALLLLLL 383
|
|
| MFS_MCT_SLC16 |
cd17352 |
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ... |
17-433 |
3.39e-07 |
|
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340910 [Multi-domain] Cd Length: 361 Bit Score: 52.17 E-value: 3.39e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 17 YLILLIIFIVTAVNYADRATLSIAGTEVAKELQLSAVSMGYIFSAFGWAYLLMQIPGGWLLDKFGSKKVYTYSLFFWSLF 96
Cdd:cd17352 2 WVVVFASFLVNFFTDGILNSFGVLFVELLEEFGESTSDIAWIGSLLLGVSLFSGPLSSALVNRFGCRPVAIAGGLLAALG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 97 TFLQGFVDMFPLAwagisMFFMRFMLGFSEAPSFPANARIVAAWFpTKERGTASAIFNSAQYFSLALFSPLLGWLTFAWG 176
Cdd:cd17352 82 LLLSSFATSLWQL-----YLTYGVLGGLGLGLIYSPAIVIVGQYF-EKKRGLATGIAVAGSGVGTFVFPPLLRYLLDNYG 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 177 WEHVFTVMGVIGFVLTALWIKLihnptdhprmsaeelkfisengavvdmdhkkpgsaaasgpklhyikQLLSNRMMLGVF 256
Cdd:cd17352 156 WRGALLILGGLCLNLCVCGLLL----------------------------------------------RLLKDPTFVLLA 189
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 257 FGQYFINTITWFFLTWFPIYLvQEKGMSILKVGLVASIPALCGFAGGVLGGVFSDYLIKRGLSLTLarklpIVLGMLLAS 336
Cdd:cd17352 190 LGVSFAMLGFFVPFVYLPSYA-KSLGIDESDAAFLLSIIGISDIVGRILLGLLADKPRIGRLYLYI-----FTLLILGLS 263
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 337 TIILCNYTNNTTLVVMLMALAFFGKGFGALGWPVISDTAPKEIVGLCGGVFNVFGNVASIVTPLVIGYLVSELHSFNAAL 416
Cdd:cd17352 264 LLAFPLATTYVGLIVFSVLFGFCSGSYSSLTPVILADLVGLEKLSNAYGLVLLFQGLAALVGPPIAGLLRDYTGDYDAAF 343
|
410
....*....|....*..
gi 1487549706 417 VFVGCSALMAMVCYLFV 433
Cdd:cd17352 344 YFCGACLLLSGVLLFLL 360
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
18-198 |
4.09e-07 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 51.80 E-value: 4.09e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 18 LILLIIFIVTAVNYADRATLSIAGTEVAKELQLSAVSMGYIFSAFGWAYLLMQIPGGWLLDK-FGSKKVYTYSLFFWSLF 96
Cdd:cd17474 199 GLLTFLVSAFLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVLLALGSLFVGRLLKKrFGARRILVIGLLLYALS 278
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 97 TFLQGFVDMFPLAWAGISMFfmrfmlGFSEAPSFPANARIVAAWFPTKERGTASAIFNSAQYFSLALFSPLLGWLTFAWG 176
Cdd:cd17474 279 LLLLGFVPSLALLLIAIVLF------GLGLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFG 352
|
170 180
....*....|....*....|..
gi 1487549706 177 WEHVFTVMGVIGFVLTALWIKL 198
Cdd:cd17474 353 LSAPFLVGAAIALAAAVLLALL 374
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
255-434 |
4.43e-07 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 51.65 E-value: 4.43e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 255 VFFGQYFINTITWFFLTWFPIYLVQEKGMSILKVGLVASIPALCGFAGGVLGGVFSDYLIKRglsltlaRKLPIVLGMLL 334
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRR-------RVLLIGLLLFA 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 335 ASTIILCNYTNNTTLVVMLMALAFFGKGFGALGWPVISDTAPKEIVGLCGGVFNVFGNVASIVTPLVIGYLVSeLHSFNA 414
Cdd:pfam07690 74 LGLLLLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLAS-LFGWRA 152
|
170 180
....*....|....*....|
gi 1487549706 415 ALVFVGCSALMAMVCYLFVV 434
Cdd:pfam07690 153 AFLILAILSLLAAVLLLLPR 172
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
255-438 |
6.44e-07 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 51.07 E-value: 6.44e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 255 VFFGQYFINTITWFFLTWFPIYLVQEKGMSILKVGLVASIPALCGFAGGVLGGVFSDYlikrglsltLARKLPIVLGMLL 334
Cdd:cd17329 4 LLIGSFLNRLGFFMVWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADR---------FGRKPVMLAGLLL 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 335 -ASTIILCNYTNNTTLVVMLMALAFFGKG-FGALGWPVISDTAPKEIVGLCGGVFNVFGNVASIVTPLVIGYLVseLHSF 412
Cdd:cd17329 75 rALGFALLGFAHSPWLFAIALVLTGFGGGlFEPASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLL--LYSF 152
|
170 180
....*....|....*....|....*.
gi 1487549706 413 NAALVFVGCSALMAMVCYLFVVGDIK 438
Cdd:cd17329 153 RLLFLAAAVLFLLAALVLLFLLPETR 178
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
273-436 |
7.07e-07 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 51.04 E-value: 7.07e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 273 FPIYlVQEKGMSILKVGLVASIPALCGFAGGVLGGVFSDylikrglslTLARKLPIVLGMLL-ASTIILCNYTNNttlVV 351
Cdd:cd17325 19 LPLY-AESLGASVAQIGLIVAAYALAQLLFSPPAGRLSD---------RFGRKRLLLLGLLLlAVSTLLFAFATS---YW 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 352 MLMALAFFGKGFGALGWPV----ISDTAPKEIVGLCGGVFNVFGNVASIVTPLVIGYLvSELHSFNAALVFVGCSALMAM 427
Cdd:cd17325 86 QLLLARFLQGLASAAVWPAamalIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLL-ADALGYRAPFLVCAALALLAL 164
|
....*....
gi 1487549706 428 VCYLFVVGD 436
Cdd:cd17325 165 VLALLLLPE 173
|
|
| MFS_PcaK_like |
cd17365 |
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ... |
20-194 |
1.00e-06 |
|
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340923 [Multi-domain] Cd Length: 351 Bit Score: 50.66 E-value: 1.00e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 20 LLIIFIVTAVNYADRATLSIAGTEVAKELQLSAVSMGYIFSAFGWAYLLMQIPGGWLLDKFGSKKVYTYSLFFWSLFTFL 99
Cdd:cd17365 1 LALCFLIIVLDGFDLAVMGFVAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 100 QGFvdmfplAWAGISMFFMRFMLGFSEAPSFPANARIVAAWFPTKERGTASAIFNSAQYFSLALFSPLLGWLTFAWGWEH 179
Cdd:cd17365 81 TAF------AQSVLQLALLRFLTGLGLGAAMPNAITLVSEYAPARRRSLAVTLMFCGYPLGAALGGFLAAALIPAFGWRS 154
|
170
....*....|....*
gi 1487549706 180 VFTVMGVIGFVLTAL 194
Cdd:cd17365 155 VFLLGGVPPLILLPL 169
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
16-191 |
1.19e-06 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 50.29 E-value: 1.19e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 16 RYLILLIIFIVTAVNYADRATLSIAGTEVAKELQLSAVSMGYIFSAFGWAYLLMQIPGGWLLDKFGSKKVYTYSLFFWSL 95
Cdd:cd17316 176 RRRTLLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGI 255
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 96 FTFLQGFVDMFPLAWagisMFFMRFMLGFSEAPSFPANARIVAAWFPTKERGTASAIFNSAQYFSLALFSPLLGWLTFAW 175
Cdd:cd17316 256 LALPLFYLLSGSPTL----LLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLAST 331
|
170
....*....|....*.
gi 1487549706 176 GWEHVFTVMGVIGFVL 191
Cdd:cd17316 332 GGTGVPALILALLAIV 347
|
|
| glpT |
PRK11273 |
glycerol-3-phosphate transporter; |
16-433 |
1.22e-06 |
|
glycerol-3-phosphate transporter;
Pssm-ID: 236889 [Multi-domain] Cd Length: 452 Bit Score: 50.48 E-value: 1.22e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 16 RYLILLIIFIVTAVNYADRATLSIAGTEVAKE--------LQLSAVSMGYIFSAFgwaylLMqipgGWLLDKFGSKKVYT 87
Cdd:PRK11273 27 RWQIFLGIFFGYAAYYLVRKNFALAMPYLVEQgfsrgdlgFALSGISIAYGFSKF-----IM----GSVSDRSNPRVFLP 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 88 YSLFFWSLFTFLQGFVdmfPLAWAGIS-MFFMRFMLGFSEAPSFPANARIVAAWFPTKERGTASAIFNSAQYFSLALFsP 166
Cdd:PRK11273 98 AGLILAAAVMLFMGFV---PWATSSIAvMFVLLFLCGWFQGMGWPPCGRTMVHWWSQKERGGIVSVWNCAHNVGGGLP-P 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 167 LLGWLTFAW--GWEHVFtVMGVIGFVLTAL--WIKLIHNPTDHPRMSAEELKfiseNGAVVDMDHKKPGSAAAsgpKLHY 242
Cdd:PRK11273 174 LLFLLGMAWfnDWHAAL-YMPAFAAILVALfaFAMMRDTPQSCGLPPIEEYK----NDYPDDYNEKHEQELTA---KQIF 245
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 243 IKQLLSNRMMLGVFFGQYFINTITWFFLTWFPIYLVQEKGMSILKVGLVASIPALCGFAGGVLGGVFSDYLIK--RGLSL 320
Cdd:PRK11273 246 MQYVLPNKLLWYIAIANVFVYLLRYGILDWSPTYLKEVKHFALDKSSWAYFLYEYAGIPGTLLCGWMSDKVFRgnRGATG 325
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 321 TLARKLpivlgMLLASTIILCNYTNNTTL-VVMLMALAFFGKGFGALGWPVISDTAPKEIVGLCGGVFNVFGNV-ASIVT 398
Cdd:PRK11273 326 VFFMTL-----VTIATIVYWLNPAGNPTVdMACMIVIGFLIYGPVMLIGLHALELAPKKAAGTAAGFTGLFGYLgGSVAA 400
|
410 420 430
....*....|....*....|....*....|....*
gi 1487549706 399 PLVIGYLVSELHSFNAALVFVGCSALmAMVCYLFV 433
Cdd:PRK11273 401 SAIVGYTVDFFGWDGGFMVMIGGSIL-AVILLIVV 434
|
|
| MFS_FucP_MFSD4_like |
cd17333 |
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ... |
35-431 |
1.34e-06 |
|
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340891 [Multi-domain] Cd Length: 372 Bit Score: 50.01 E-value: 1.34e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 35 ATLSIAGTEVAKELQLSAVSMGYIFSAFGWAYLLMQIPGGWLLDKFGSKKVYTYSLFFWSLFTFLQGFVDMFPLAWAgiS 114
Cdd:cd17333 13 ALLGILGPSLEEAFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIYLFVV--L 90
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 115 MFFMRFMLGFSEApsfPANARIVAAWfptKERGTASAIFNSAQYFSLALFSPLLGWLTFAWG--WEHVFTVMGVIGFVLT 192
Cdd:cd17333 91 MFLAGLGAGILDT---GANTFVGALF---EESSATRLNVLHGFFGLGALIGPLIATSLLTSElsWSWAYLIIGLIYLLLA 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 193 ALWIKLIHNPTDHPRMSAeelkfisengavvdmdhKKPGSAAASGPKLHYIKQLLsnrmMLGVFFGQYFINTITwfFLTW 272
Cdd:cd17333 165 ILILLTLFPELPSARNPQ-----------------QSVGAFSASASRLLRNPSII----LGALALFLYVGAETA--FSSW 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 273 FPIYLVQEKGMSILKVGLVASIPALCGFAGGVLGGVFSDYLIKRGLsltlarklpiVLGMLLASTIILCNYTNNTTLVVM 352
Cdd:cd17333 222 VPSYLVEKKHVSDGLAGYLLSGFWVGITIGRLLGGPISRRIKPHTL----------LVLSGSGALLGLLILLLAPTLVVG 291
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 353 LMALAFFGKGFGALGWPVISDTAP--KEIVGLCGGVFNVFGNVASIVTPLVIGYLVSELHSFNAALVFVGCSALMAMVCY 430
Cdd:cd17333 292 LVATALLGLFMAALFPTILSLGISnlPYAKGKGTSVLLAAGSIGGAIIPFIMGFIAEAVGIQTAMLLITILYAIIFVLAL 371
|
.
gi 1487549706 431 L 431
Cdd:cd17333 372 L 372
|
|
| MFS_SLC49 |
cd17334 |
Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily of transporters; The ... |
15-432 |
2.15e-06 |
|
Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily of transporters; The Solute carrier 49 (SLC49) family is composed of four members: feline leukemia virus subgroup C receptor 1 (FLVCR1, SLC49A1); FLVCR2 (SLC49A2); major facilitator superfamily domain-containing protein 7 (MFSD7, SLC49A3); and disrupted in renal carcinoma protein 2 (DIRC2, SLC49A4). FLVCR1 and FLVCR2 are heme transporters. In addition, FLVCR2 also functions as a transporter for a calcium-chelator complex that is important for growth and calcium metabolism. The function of MFSD7 is unknown. DIRC2 is an electrogenic lysosomal metabolite transporter that is regulated by limited proteolytic processing by cathepsin L. The SLC49 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340892 [Multi-domain] Cd Length: 407 Bit Score: 49.71 E-value: 2.15e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 15 TRYLILLIIFIVTAVNYADRATLSIAGTEVAKELQLSAVSMGYIFSAFGWAYLLMQIPGGWLLDKFGSKkvytYSLFFWS 94
Cdd:cd17334 1 RRWVVLLLFSLLSFSNAMQWITFSPIADEARTFFDLSASQINWLSLVYPIVYVPGVFAFCWLLDKVGLR----IGVLIGA 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 95 LFTFLQGFVDMFPLAWAGISMFFM--RFMLGFSEAPSFPANARIVAAWFPTKERGTASAIFNSAQYFSLA---LFSPLLG 169
Cdd:cd17334 77 ALNALGSVLKCIPLGQQPKFALLVlgQVLNALAQVLVLSLPPLIAAVWFPPKERTTATAIASLANFLGCAigfLLPPVVV 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 170 WLT--FAWGWEHVFTvmGVIGFVLTALWIKLIHNPtDHPRMSAEELKFISENGAVVDMDHKkpgsaaasgpklHYIKQLL 247
Cdd:cd17334 157 PPPkgTKKEFGAVFY--GEFGFACLLLALVLALFP-PKPKYPPSAASARQQNSEHVILELQ------------KSISELL 221
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 248 SNR--MMLGVFFGqyfinTITWFFLTWFPIY--LVQEKGMSILKVGLVASIPALCGFAGGVLGGVFSDY---LIKRGLSL 320
Cdd:cd17334 222 RNEpfVLLAVAFS-----IMMGVFAGFSSVLaqILLPFGVSQTSAGWLGFFGIVAGMVGGLLLGLFVDRtrmFKLIGLII 296
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 321 TLARKLPIVLGMLLASTIILCNYTnnTTLVVMLMALAFFGKGFGALGWPVISDTAPKEIVGLCGGVFNVFGNVASIVTPL 400
Cdd:cd17334 297 LALGTVVCTFFMLLVDRYGLPYVT--LAFYLLCGLLGFFQNSMVPIMFELAVELTYPVPESVSTGVLTALANLFSFLLML 374
|
410 420 430
....*....|....*....|....*....|...
gi 1487549706 401 VIGYLVSELHSFNAAL-VFVGCSALMAMVCYLF 432
Cdd:cd17334 375 VFSELLGPTPTESKYLlWFILCTVGSCLGALFF 407
|
|
| PRK11663 |
PRK11663 |
glucose-6-phosphate receptor/MFS transporter UhpC; |
14-191 |
3.95e-06 |
|
glucose-6-phosphate receptor/MFS transporter UhpC;
Pssm-ID: 183266 [Multi-domain] Cd Length: 434 Bit Score: 48.94 E-value: 3.95e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 14 HTRYLILLIIFIVTAVNYADRATLSIAGTEVAKELQLSAVSMGYIFSAFGWAYLLMQIPGGWLLDKFGSKKVYTYSLFFW 93
Cdd:PRK11663 19 YWRRHILITMYLGYALFYFTRKSFNAAMPEMLADLGLSRSDIGLLATLFYITYGVSKFVSGIVSDRSNARYFMGIGLIAT 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 94 SLFTFLQGF---VDMFPLAWAgISMFFMRFmlgfseapSFPANARIVAAWFPTKERGTASAIFNSAQYFSLALFSPLLGW 170
Cdd:PRK11663 99 GIINILFGFsssLWAFALLWV-LNAFFQGW--------GWPVCAKLLTAWYSRTERGGWWAIWNTAHNVGGALIPLVVGA 169
|
170 180
....*....|....*....|.
gi 1487549706 171 LTFAWGWEHVFTVMGVIGFVL 191
Cdd:PRK11663 170 IALHYGWRYGMMIAGIIAIVV 190
|
|
| MFS_Tpo1_MDR_like |
cd17323 |
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ... |
19-432 |
1.14e-05 |
|
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340881 [Multi-domain] Cd Length: 376 Bit Score: 47.18 E-value: 1.14e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 19 ILLIIFIVTAVNYADrATLSIAGTEVAKELQLSAVSMGYIFSAFGWAYLLMQIPGGWLLDKFGSKKVYTYSLFFWSLFTF 98
Cdd:cd17323 1 VFIISFLTFVVTFGS-SIYSPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQI 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 99 LQGFVDMFPlawagiSMFFMRFMLGFSEAPSFPANARIVAAWFPTKERGTASAIFNSAQyFSLALFSPLLG-WLTFAWGW 177
Cdd:cd17323 80 GCALAPNIA------MLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGP-LLGPALGPIIGgFITQSLGW 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 178 EHVFTVMGVIGFVlTALWIKLIHNPTdhprmsaeelkfisengavvdmdhkkpgsaaasgpklhyikqllsnrMMLGVFF 257
Cdd:cd17323 153 RWIFWFLAIISGF-CLILIFLFLPIV-----------------------------------------------LLLGLYV 184
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 258 GqyFINTITWFFLTWFPIYLVQEKGMSILKVGLVASIPALCGFAGGVLGGVFSDY-----LIKRGLSLTLARKLPIVLGM 332
Cdd:cd17323 185 G--LVYAILYLFLTAFPYVFGEVYGFSPGEVGLMYLPIGIGALIGSIIGGRLSDYyyrrlKKKNGGKPEPEARLPPAFIG 262
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 333 LLASTIILCNY----TNNTTLVVMLMALAFFGKGFGALGWPV---ISDTAPKEiVGLCGGVFNVFGNVASIVTPLVIGYL 405
Cdd:cd17323 263 AFLFPIGLFIFgwtiYPHIHWIVPIIGSAFFGFGLMLIFQSSltyLVDSYPKY-AASALAANTLVRSIFAAIFPLFAQPM 341
|
410 420
....*....|....*....|....*..
gi 1487549706 406 VSELHSFNAALVFVGCSALMAMVCYLF 432
Cdd:cd17323 342 FNNLGVGWAFTLLAFISLAMIPIPFIF 368
|
|
| MFS_MCT_like |
cd17314 |
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator ... |
16-433 |
1.42e-05 |
|
Monocarboxylate transporter (MCT) family and similar transporters of the Major Facilitator Superfamily; The group is composed of the Monocarboxylate transporter (MCT) family in animals and similar transporters from fungi, plants, archaea, and bacteria. MCT is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCTs have been found to facilitate the transport across the plasma membrane not only of monocarboxylates (MCT1-4), but also thyroid hormones (MCT8/10), and aromatic acids (MCT10). Yeast MCT homologous (Mch) proteins are not involved in the uptake of monocarboxylates; their substrates are not known. The MCT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340872 [Multi-domain] Cd Length: 385 Bit Score: 47.02 E-value: 1.42e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 16 RYLILLIIFIVTAVNYADRATLSIAGTEVAKELQLSAVSMGYIFSAFGWAYLLMQIPGGWLLDKFGSKKVYTYSLFFWSL 95
Cdd:cd17314 1 RWFVLYVSFLLSAMSTGFILSWSLFYQPWQDAFGYSSSQIATAASLSNLGMLLTQPILGFIADSFGPRPLMALAGIMVLA 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 96 FTFLQGFVDMFPLAWAGISMFFmrfmlGFSEAPSFPANARIVAAWFPTKeRGTASAIFNSAQYFSLALFSPLLGWLTFAW 175
Cdd:cd17314 81 GYTYLSYVFNSFPLSYACFVFI-----GAGTGILYGSAVLVTTQYFPDT-KGLALGLPTTGYSLGLVLGSPLLRILWVFY 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 176 GWEHVFTVMGVIGFVLTALwiklihnptdhprmsaeelkfisenGAVVDMDHKKPGSAAASGPKLHYIKQLLSNRM-MLG 254
Cdd:cd17314 155 GLALVYTILGILAAIVLSV-------------------------VSLLGFKEPPDNQARLHVQKKKTQTMGEIFRDkVFW 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 255 VFFGQYFINTITWFFLTWFPIYLVQE-KGMSILKVGLVASIPALCGFAGGVLGGVFSDYLIKRglsltlARKLPIVLG-M 332
Cdd:cd17314 210 ILFIAIFLVLIGGFLFIANMASLVRSlQLDAPSFVTKLMSIYGLFNAFGRLLWGIVADFFGGR------LSTLSILLTiL 283
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 333 LLASTIILCNYTNNTTLVVMLMALAFFGKGfgalGWPVISDTAPKEIVGL-----CGGVFNVFGNVASIVTPLVIGYLVS 407
Cdd:cd17314 284 GLGLCAFLFLLKMTPVGLVLTGSLLGFSYG----GLFTVYPATVSTVFGTesfatLYGILLFAPAIGSILGPMLGAKFYD 359
|
410 420
....*....|....*....|....*.
gi 1487549706 408 ELHSFNAALVFVGCSALMAMVCYLFV 433
Cdd:cd17314 360 RTPSYISAVYIYAVIVFLASAILLAV 385
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
282-441 |
2.44e-05 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 46.39 E-value: 2.44e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 282 GMSILKVGLVASIPALCGFAGGVLGGVFSDYLIKRGLSLTLarklpivLGMLLASTIILCNYTNNTTLVVMLMALAFFGK 361
Cdd:cd17324 30 GVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVL-------LLLFILGNLLAALAPSFALLLLARALAGLAHG 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 362 GFGALGWPVISDTAPKEIVGLCGGVFnVFGNVASIVTPLVIGYLVSELHSFNAALVFVGCSALMAMVCYLFVVGDIKRME 441
Cdd:cd17324 103 GFWAIAAAYAADLVPPEKRGRAIGLV-FSGLTLGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWRLLPSLPPKK 181
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
17-171 |
2.95e-05 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 46.05 E-value: 2.95e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 17 YLILLIIFIVTAVNYAdrATLSIAGTEVAKELQLSAVSMGYIFSAFGWAYLLMQIPGGWLLDKFGSKKVYTYSLFFWSLF 96
Cdd:COG2211 230 FLLLLLAYLLFFLALA--LVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALG 307
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1487549706 97 TFLQGFVDMFPLAWAGISMFFMRFMLGFSEAPSFPANARIV---AAWFPTKERGTASAIFNSAQYFSLALFSPLLGWL 171
Cdd:COG2211 308 LLLLFFLGPGNLWLLLVLAALAGIGLGAILVLPWAMLADVVdydEWKTGRRREGLYFGIFTFAIKLGQALAGALAGLL 385
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
250-434 |
3.20e-05 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 45.74 E-value: 3.20e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 250 RMMLGVFFGQYFINTITWFFLTWFPiYLVQEKGMSILKVGLVASIPALCGFAGGVLGGVFSDylikrglslTLARKLPIV 329
Cdd:COG2814 10 LALLALALGAFLSGLGIGIVLPALP-LIAADLGASPAQAGLVVTAYLLGAALGAPLAGRLAD---------RFGRRRVLL 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 330 LGMLL--ASTIILCNYTNNTTLVVMLMALAFFGKGFGALGWPVISDTAPKEIVGLCGGVFNVFGNVASIVTPLVIGYLVs 407
Cdd:COG2814 80 LGLLLfaLGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLA- 158
|
170 180
....*....|....*....|....*..
gi 1487549706 408 ELHSFNAALVFVGCSALMAMVCYLFVV 434
Cdd:COG2814 159 DLFGWRWVFLVNAVLALLALLLLLRLL 185
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
43-424 |
4.49e-05 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 45.26 E-value: 4.49e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 43 EVAKELQLSAVSMGYIFSAFGWAYLLMQIPGGWLLDKFGSKKVYTYSLFFWSLFTFLQGFVDMFPLawagisMFFMRFML 122
Cdd:cd17320 24 AIARDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQ------LLIARFLQ 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 123 GFSEAPSFPANARIVAAWFPTKERGTASAIFNSAQYFSLALfSPLLG-WLTFAWGWEHVFTVMGVIGFVLTALWIKLIhn 201
Cdd:cd17320 98 GLGAAAGSVVARAIVRDLYSGAELAKIFSLLMMILAIAPAL-APLLGgLLLLFFGWRAIFVFLALLGLLLLLLVLLFL-- 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 202 PTDHPRMSAEELkfisengavvdmdhkkpgsaaaSGPKLHYIKQLLSNRMMLGVFFGQYFINTITWFFLTWFPIYLVQEK 281
Cdd:cd17320 175 PETLPEEKRKPL----------------------LSSLLRAYKRVLKNRRFLGYALALGLSFAGLFAYLAAAPFIYIEQL 232
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 282 GMSILKVGLVASIPALcgfaGGVLGGVFSDYLIKRGLSLTLARkLPIVLGMLLASTIILCNYTNNTTLVVMLMALAFFGK 361
Cdd:cd17320 233 GLSPAQFGLLFALNAI----ALILGSLLNGRLVRRFGPRRLLR-LGLLLLLAAALVLLLAALLGGLSLWPLVAPLFLIFF 307
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1487549706 362 GFGALGwpVISDTAPKEIVGLCGGVFNVFGNVASIVTPLVIGYLVSELHSFNAALVFVGCSAL 424
Cdd:cd17320 308 GFGLIF--PNATSLALEPFPHVAGTASALLGFLQFLIGALAGALVGLLPNGTALPMGLLILVL 368
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
20-165 |
1.69e-04 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 43.56 E-value: 1.69e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 20 LLIIFIVTAVNYADRATLSIAGTEVAKELQLSAVSMGYIFSAFGWAYLLMQIPGGWLLDKFGSKKVYtysLFFWSLFTFL 99
Cdd:pfam07690 202 VLWLLLALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRL---LLALLLLILA 278
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1487549706 100 QGFVDMFPLAWAGISMFFMRFMLGFSEAPSFPANARIVAAWFPTKERGTASAIFNSAQYFSLALFS 165
Cdd:pfam07690 279 ALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| 2A0108 |
TIGR00886 |
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions] |
45-365 |
2.05e-04 |
|
nitrite extrusion protein (nitrite facilitator); [Transport and binding proteins, Anions]
Pssm-ID: 273322 [Multi-domain] Cd Length: 354 Bit Score: 43.44 E-value: 2.05e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 45 AKELQLSAVSMGYIFSAFGWAYLLMQIPGGWLLDKFGSKKVYTYSLFFWSLFTFLQGFVDMFP--LAWagismffMRFML 122
Cdd:TIGR00886 29 KDDLGLSTAQLGNLVAVPVLAGAVLRIILGFLVDIFGPRYTTALSLLLLAIPCLWAGLAVQSYsvLLL-------IRLFI 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 123 GFSEApSFPANARIVAAWFPTKERGTASAIF----NSAQYFSLALFSPLLGWLTF--------AWGWEHVFTVMGVIGFV 190
Cdd:TIGR00886 102 GIAGG-SFASCMPWISFFFPKKIQGTALGLAagwgNMGGGVAQFVMPPIIGSLIFgggqpahlAWGWAFVIVPAGILLLP 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 191 LTALWIKLIHNPTDhprmsaeelkfisengavvdmdhKKPGSAAASGPKLHYIKQLLSNRMML------GVFFGqyfint 264
Cdd:TIGR00886 181 ALLIFFVGADTPPG-----------------------KPATGKLSFKEALKVFGNRHTWILALlysvtfGSFLG------ 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 265 itwfFLTWFPIYLVQEKGMSILKVGLVASIPALCGFAGGVLGGVFSDYLIKRGLSLTLARKLPIVLGMLLASTIILCNYT 344
Cdd:TIGR00886 232 ----VSSIFAMLFKDQFGLSKVQAGAYASLGGFLGSLARPAGGAISDRLGGARKLLMNFLGVAMGAFLVVLGLVSDGSLA 307
|
330 340
....*....|....*....|.
gi 1487549706 345 nnTTLVVMLMALAFFGKGFGA 365
Cdd:TIGR00886 308 --AFIVLFVALFFFAGAGNGS 326
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
9-196 |
2.30e-04 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 43.30 E-value: 2.30e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 9 KKKGVHTRYLILLIIFIVTAVNYADRATLSIAgtevAKELQLSAVSMGYIFSAFGWAYLLMQIPGGWLLDKFGSKKVYTY 88
Cdd:cd17370 194 SLKKLPKAFWLYLLAVALFALGNFSFAFLILR----AQELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLIL 269
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 89 SLFFWSLFTFLQGFVDMFPLAWAGISMFFMrfMLGFSEApSFPAnarIVAAWFPTKERGTASAIFNSAQYFSLALFSPLL 168
Cdd:cd17370 270 GYLSLALAYLGFALGSSLWLLLLGFILWGL--YMGAQES-IERA---AVADLVPAELRGTAYGLFNTVVGIGWLLASLIA 343
|
170 180
....*....|....*....|....*...
gi 1487549706 169 GWLTFAWGWEHVFtVMGVIGFVLTALWI 196
Cdd:cd17370 344 GYLWDLISPSAAF-LFSAVLALIALLLL 370
|
|
| MFS_PhT |
cd17364 |
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This ... |
70-433 |
2.48e-04 |
|
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of predominantly fungal and plant high-affinity inorganic phosphate transporters (PhT or PiPT), which are involved in the uptake, translocation, and internal transport of inorganic phosphate. They also function in sensing external phosphate levels as transceptors. Phosphate is crucial for structural and metabolic needs, including nucleotide and lipid synthesis, signalling and chemical energy storage. The Pht subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340922 [Multi-domain] Cd Length: 389 Bit Score: 43.04 E-value: 2.48e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 70 QIPGGWLLDKFGSKKVYTYSLFFWSLFTFLQGFVDMFPLAWAGISMFFMRFMLGFSEAPSFPANARIVAAWFPTKERGTA 149
Cdd:cd17364 56 QLFFGFLGDRFGRKRVYGVELIIMIIGTILSALSPGSTPLGVMGWLIFFRFLLGIGIGGDYPLSATIMSEYANKKRRGAL 135
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 150 SAIFNSAQyfslalfspllgwltfAWGwehvFTVMGVIGFVLTALWiklihnptdhprmsaeelkfisengavvdmDHKK 229
Cdd:cd17364 136 IAAVFAMQ----------------GFG----ILAGAIVTLILSAIF------------------------------EHPL 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 230 PGSAAasgPKLHYIKQLLsnrMMLGVFFG--------QYFINTITWFFL--TWFPIYLVQ---------EKGMSILKVGL 290
Cdd:cd17364 166 PAGTY---HHADLVWRIV---LGLGAIPAlsvlyfrkHLLGTAGTWFLLdiAFYGQNLFQstiisaigfSKTMNAYQELF 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 291 VASI-PALCGFAGGVLGGVFSDYLIKRglsltLARKLPIVLG------MLLASTIILCNYTNNTTLVVMLMALAFFGKGF 363
Cdd:cd17364 240 NIAVgQLIIALAGTVPGYWFTVFLIDR-----IGRKKIQMMGffgmtiFLLILAGPYDHWKISTIGFFVLYGLTFFFSNF 314
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1487549706 364 G--ALGWPVISDTAPKEIVGLCGGVFNVFGNVASIVTPLVIGYLVSELHSFNAALVFVGCSALMAMVCYLFV 433
Cdd:cd17364 315 GpnTTTFIVPAEVFPARVRSTCHGISAASGKIGAIVGSFLFLSLTQNIGVRNVLIILAGVALLGIILTLLFP 386
|
|
| MFS_MMR_MDR_like |
cd17504 |
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ... |
44-433 |
3.14e-04 |
|
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341047 [Multi-domain] Cd Length: 371 Bit Score: 42.56 E-value: 3.14e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 44 VAKELQLSAVSMGYIFSAFGWAYLLMQIPGGWLLDKFGSKKVYTYSLFFWSLFTFLQGFVDMFPLawagisMFFMRFMLG 123
Cdd:cd17504 22 IQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPV------LIAGRALQG 95
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 124 FSeAPSFPANARIVAAWFPTKERGTASAIFNSAQYFSLALFSPLLGWLTFAWGWEHVFTVMGVIGFVLTALwiklihnpt 203
Cdd:cd17504 96 IG-GAVFPLAFALVREEFPPERVPVAQGILSATFGIGAGIGLPLGGWIVQHLGWRWIFWTAAPVAVLLAAL--------- 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 204 dhprmsaeelkfisenGAVVDMDhkkpgsaaasgpklhyikqLLSNRMMLGVFFGQYFINTITWFFLTWFPIYLVQEK-- 281
Cdd:cd17504 166 ----------------VPLIDLR-------------------LLRRRNVLLANITALLAGFGMFMVFQLLPQLLQLPTpt 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 282 --GMSILKVGLVASIPALCGFAGGVLGGvfsdYLIKRGLSltlarKLPIVLGMLLASTIILCNYTNNTTLVVMLMALAFF 359
Cdd:cd17504 211 gfGLGITEAGLLLLPGALVMLIAGPLAG----RLIARVGP-----RRVLLIGLVISAVGLLLLALLHSSLWALVVALLLI 281
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 360 GKGFG---ALGWPVISDTAPKEIVGLCGGVFNVFGNVASIVTPLVIGYL------------VSELHSFNAALVFVGCSAL 424
Cdd:cd17504 282 GIGLGlafASLPNIVVESVPPDRTGIATGMNTVLRTIGSAIGPAIAGAIlttytvsitsggVPTEGAYVLAFLIGAALAL 361
|
....*....
gi 1487549706 425 MAMVCYLFV 433
Cdd:cd17504 362 AALLLSLLI 370
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
45-363 |
3.36e-04 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 42.59 E-value: 3.36e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 45 AKELQLSAVSMGYIFSAFGWAYLLMQIPGGWLLDKFGSKKVYTYSLFFWSLFTFLqgfvdMFPLAWAGISMFFMRFMLGF 124
Cdd:cd17490 23 AESLGASLSMIGIILGAYGISQMLLRIPLGILSDRIGKRKLFIIIGLLFTVLASL-----IMILFPSPWGLLIARFLSGI 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 125 SEAPSFPANArIVAAWFPTKERGTASAIFNSAQYFSLALFSPLLGWLTFAWGWEHVFTV---MGVIGFVLTAlwiklihn 201
Cdd:cd17490 98 AAATWVSFTV-LYASYFPPDEAAKAMGLINLVNNLGQLIAFLIGGLIAEHFGMRAPFLLaalAGVLGFILSL-------- 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 202 ptdhprmsaeelkFISEngavvdmdhkKPGSAAASGPKLHYIKQLLSNRMMLGVFF---GQYFINTITWFFLTwfPIYLV 278
Cdd:cd17490 169 -------------FIKE----------ERREKKPVLTELKELLSVLKDKKLLFFSLlaiLQQMITFSTTFGFT--PLIAK 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 279 QEkGMSILKVGLVASIPALCGFAGGVLGG-VFSDYLIkrglsltlARKLPIVLGMLLASTIILCNYTNNTTLVVMLMALA 357
Cdd:cd17490 224 QL-GASSFQLGLLSIIYLLPNALASLLSGtLFYKKLG--------ERNTIIIGFLLLGAYCFLIPFAPNLTLLYLLQALN 294
|
....*.
gi 1487549706 358 FFGKGF 363
Cdd:cd17490 295 GFGTGI 300
|
|
| 2A0119 |
TIGR00898 |
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds] |
46-196 |
4.74e-04 |
|
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273328 [Multi-domain] Cd Length: 505 Bit Score: 42.31 E-value: 4.74e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 46 KELQLSAVSMGYIFSAFGWayllmqipgGWLLDKFGSKKVYTYSLFFWSLFTFLQGFVDMFPlawagiSMFFMRFMLGFS 125
Cdd:TIGR00898 129 VDLTQSCFFVGVLLGSFVF---------GYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYT------VFLVFRLLVGMG 193
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1487549706 126 EAPSFPANARIVAAWFPTKERGTASAIFNSAqyFSLALFS-PLLGWLTFAWGWEHVFTVMGVIGFVLTALWI 196
Cdd:TIGR00898 194 IGGIWVQAVVLNTEFLPKKQRAIVGTLIQVF--FSLGLVLlPLVAYFIPDWRWLQLAVSLPTFLFFLLSWFV 263
|
|
| MFS_MdfA_MDR_like |
cd17320 |
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ... |
23-191 |
6.11e-04 |
|
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340878 [Multi-domain] Cd Length: 379 Bit Score: 41.79 E-value: 6.11e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 23 IFIVTAVNYADRATLSIAGTEVAKELQLSAVSMGYIFSAFGWAYLLMQIPGGWLLDKFGSKKV-------YTYSLFFWSL 95
Cdd:cd17320 207 ALALGLSFAGLFAYLAAAPFIYIEQLGLSPAQFGLLFALNAIALILGSLLNGRLVRRFGPRRLlrlglllLLAAALVLLL 286
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 96 FTFLQgfvdMFPLAWAGISMFFMRFMLGFSeapsFPANARIVAAWFPtKERGTASAIFNSAQYFSLALFSPLLGWLTFAW 175
Cdd:cd17320 287 AALLG----GLSLWPLVAPLFLIFFGFGLI----FPNATSLALEPFP-HVAGTASALLGFLQFLIGALAGALVGLLPNGT 357
|
170
....*....|....*...
gi 1487549706 176 GWEH--VFTVMGVIGFVL 191
Cdd:cd17320 358 ALPMglLILVLGLLALLL 375
|
|
| MFS_FLVCR_like |
cd17398 |
Feline leukemia virus subgroup C receptor subfamily of the Major Facilitator Superfamily of ... |
16-152 |
7.82e-04 |
|
Feline leukemia virus subgroup C receptor subfamily of the Major Facilitator Superfamily of transporters; The Feline leukemia virus subgroup C receptor (FLVCR) subfamily is conserved in metazoans and is composed of two vertebrate members, FLVCR1 and FLVCR2. FLVCR1 is a heme transporter and it has two isoforms: 1 (or FLVCR1a), which exports cytoplasmic heme as well as coproporphyrin and protoporphyrin IX; and 2 (FLVCR1b), which promotes heme efflux from the mitochondrion to the cytoplasm. FLVCR2 functions as a heme importer as well as a transporter for a calcium-chelator complex that is important for growth and calcium metabolism. The FLVCR subfamily belongs to the Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340956 [Multi-domain] Cd Length: 406 Bit Score: 41.46 E-value: 7.82e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 16 RYLILLIIFIVTAVNYADRATLSIAGTEVAKELQLSAV-----SMGYIFsafgwAYLLMQIPGGWLLDKFGSKKVYTYSL 90
Cdd:cd17398 2 RWIMLFLFCLYSMSNAFQWIQYAIISNIIVDYYGVSDTavdwtSMIYML-----TYIPLIFPATWLLEKYGLRVTVLLGS 76
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1487549706 91 FFWSLFTFLQGFV---DMFPLAWAGISMFFMR--FMLGFSeapsfpanARIVAAWFPTKERGTASAI 152
Cdd:cd17398 77 FLNCLGAWLKLFSsspDLFWVAMAGQTICALAqvFILGIP--------PRLAAVWFGPDEVSTATAI 135
|
|
| MFS_SLC22 |
cd17317 |
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ... |
73-196 |
8.07e-04 |
|
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340875 [Multi-domain] Cd Length: 331 Bit Score: 41.41 E-value: 8.07e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 73 GGWLLDKFGSKKVYTYSLFFWSLFTFLQGFVDMFPLawagisMFFMRFMLGFSEAPSFPANARIVAAWFPTKERGTASAI 152
Cdd:cd17317 45 FGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYEL------FLVLRFLVGVTSAGIFTVGFVLGMEIVGPKYRSFVGIL 118
|
90 100 110 120
....*....|....*....|....*....|....*....|....
gi 1487549706 153 FNSAQYFSLALFsPLLGWLTFAWGWEHVFTVMGVIGFVLTALWI 196
Cdd:cd17317 119 FGLFWALGYMLL-ALLAYLIRDWRWLQLAISLPGLLFLLLLWWL 161
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
45-195 |
9.12e-04 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 41.39 E-value: 9.12e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 45 AKELQLSAVSMGYIFSAFGWAYLLMQIPGGWLLDKFGSKKVYTYSLFFWSLFTFLQGFVDMFPLAWAGISmffmrFMLGF 124
Cdd:cd17477 215 GLRLGLSVAQAALLLAAFVLGGLLLQWPLGWLADRFDRRRVLLGCALLGALAALLLPLVPGLPLALLVLL-----FLWGG 289
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1487549706 125 SEAPSFPANARIVAAWFPTKERGTASAIFNSAQYFSLALFSPLLGWLTFAWGWEHVFTVMGVIGFVLTALW 195
Cdd:cd17477 290 AAGPLYTLALALAGDRLPGDELVAANAALLLLYGLGSVIGPLLAGALMDAFGPHGLFLFLAAVALLFLLFL 360
|
|
| PRK03893 |
PRK03893 |
putative sialic acid transporter; Provisional |
42-197 |
1.45e-03 |
|
putative sialic acid transporter; Provisional
Pssm-ID: 179668 [Multi-domain] Cd Length: 496 Bit Score: 40.84 E-value: 1.45e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 42 TEVAKELQL------SAVSMGYIFSAFGWAYLlmqipgGWLLDKFGSKKVYTYSLFFWSLFTFLQGFvdmfplAWAGISM 115
Cdd:PRK03893 44 TEVQGEFGLttvqaaSLISAAFISRWFGGLLL------GAMGDRYGRRLAMVISIVLFSVGTLACGF------APGYWTL 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 116 FFMRFMLGFSEAPSFPANARIVAAWFPTKERGTASAIFNSAQYFSLALFSPLLGWLTFAWGWEHVFTVmGVIGFVLtALW 195
Cdd:PRK03893 112 FIARLVIGMGMAGEYGSSATYVIESWPKHLRNKASGFLISGFSIGAVVAAQVYSLVVPVWGWRALFFI-GILPIIF-ALW 189
|
..
gi 1487549706 196 IK 197
Cdd:PRK03893 190 LR 191
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
20-431 |
1.81e-03 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 40.22 E-value: 1.81e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 20 LLIIFIVTAVNYADRA-TLSIAGTEvakELQLSAVSMGYIFSAFGWAYLLMQIPGGWLLDKFGSKKVY-TYSLFFWSLFT 97
Cdd:cd17471 1 LLLATLLTGLAGAFVLpYLSLFLTE---ELGASPLQIGIFMTLSALSGIVVSQWLGRLSDRGGDRKPLiLLALLAGALGY 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 98 FLQGFVDMFPLAWAgISMFFMRFMlgfseAPSFP---ANARIVAAWFPTKERGTASAIFNSAqyFSLA-LFSPLLG-WLT 172
Cdd:cd17471 78 LLFAFLRNYWVLLL-VGVVLLSLG-----AAAFPqlfALAREYADRSSGRDATLFNSVLRAA--FSLAwVIGPPLAfLLL 149
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 173 FAWGWEHVFTVMGVIGFVLTALWIKLIHNPTDHPRMSAEELKFISengavvdmdhkkpgsaaasgpklhyikqLLSNRMM 252
Cdd:cd17471 150 DVLGFTGLFLLAALLYLVVALLVLFLLPSVKPPAQKATPASSLVK----------------------------APVNRRL 201
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 253 LGVFFGQYFINTITWFFLTWFPIYLVQEKGMSILKVGLVASIPALCGFAGGVLGGVFSDYLIKRGLsltlarklpIVLGM 332
Cdd:cd17471 202 LLLFAAFTLLFAANSMYIIAMPLYVTNELGGSESWVGLLFGLAAALEIPIMLLAGLLAKRFGKRRL---------LLAGF 272
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 333 LLASTIILCNYTNNTTLVVMLMAL--AFFGKGFGALGWPVISDTAPKEIvGLCGGVFNVFGNVASIVTPLVIGyLVSELH 410
Cdd:cd17471 273 LAGVLFYLGLALATSLWQLIALQLlnAIFIGITAGLGISYFQDLMPGQP-GLATTLYSNASRIGSLLGGLLAG-VIAQYF 350
|
410 420
....*....|....*....|.
gi 1487549706 411 SFNAALVFVGCSALMAMVCYL 431
Cdd:cd17471 351 GYRAVFLVCAVLALLALVLLL 371
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
51-428 |
1.86e-03 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 40.23 E-value: 1.86e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 51 SAVSMGYIFSAFGWAYLLMQIPGGWLLDKFGSKKVYTYSLFFWSLFTFLQGFVDMFPLawagisMFFMRFMLGFSEAPSF 130
Cdd:cd17477 29 STALIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWV------WFLLRFVMGIGLAGLF 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 131 PANARIVAAWFPTKERGTASAIFNSAQYFSLALfSPLLGWLTFAWGWEHVFTVMGVIGFVLTALWIKLIHNPTDHPRMSA 210
Cdd:cd17477 103 VVSESWLNALATNENRGRVLGLYSTVLGLGFAL-GPLLLALVGTAGALPFLIAAVLLLLALVPLLLTRRAAPEIEEAESI 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 211 EELKFISengavvdmdhkkpgsaaasgpklhyikqlLSNRMMLGVFFGQYFINTitwfFLTWFPIYLVQeKGMSILKVGL 290
Cdd:cd17477 182 SLRRLLR-----------------------------IAPLALLGAFVAGFLEGA----FYSLLPLYGLR-LGLSVAQAAL 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 291 VASIPALCGFAGGVLGGVFSDYLIKRGLSLTLArklpiVLGMLLASTIILCNYTNNTTLVVMLMALAFFGkGFGALGWPV 370
Cdd:cd17477 228 LLAAFVLGGLLLQWPLGWLADRFDRRRVLLGCA-----LLGALAALLLPLVPGLPLALLVLLFLWGGAAG-PLYTLALAL 301
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 1487549706 371 ISDTAPKEIVGLCGGVFNVFGNVASIVTPLVIGYLVSELHSFNAALVFVGCSALMAMV 428
Cdd:cd17477 302 AGDRLPGDELVAANAALLLLYGLGSVIGPLLAGALMDAFGPHGLFLFLAAVALLFLLF 359
|
|
| MFS_KgtP |
cd17367 |
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This ... |
74-432 |
2.92e-03 |
|
Alpha-ketoglutarate permease of the Major Facilitator Superfamily of transporters; This subfamily includes Escherichia coli alpha-ketoglutarate permease (KgtP) and similar proteins. KgtP is a constitutively expressed proton symporter that functions in the uptake of alpha-ketoglutarate across the boundary membrane. Also included is a putative transporter from Pseudomonas aeruginosa named dicarboxylic acid transporter PcaT. The KgtP subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340925 [Multi-domain] Cd Length: 407 Bit Score: 39.59 E-value: 2.92e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 74 GWLLDKFGSKKVYTYSLFFWSLFTFLQGFVDMFPL--AWAGISMFFMRFMLGFSEAPSFPANARIVAAWFPTKERGTASa 151
Cdd:cd17367 61 GRLADRIGRRAALTLSVSLMAAGSLVIAVTPTYATigIWAPIILLLARLLQGLSVGGEYGTSATYLSEVAPPGRRGFYS- 139
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 152 ifnSAQYFS------LALFSPLLGWLTF------AWGWEHVFTVMGVIGFVltALWIKLIHNPTDHPRMSAEELKfisen 219
Cdd:cd17367 140 ---SFQYVTliggqlLALGVLLVLQHTLgedqmaAWGWRIPFLLGGVLAVV--VLWLRRGLEETESFEAIAESNE----- 209
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 220 gavvdmdhKKPGSAAASgpkLHYIKQLLsnrMMLGVFFGqyfiNTITWF-FLTWFPIYLVQEKGMS---ILKVGLVASIP 295
Cdd:cd17367 210 --------ASAGTLREL---RRHPRELL---LVVGLTAG----GTLAFYtWTTYLQKFLVNTAGFSkgdATWITTAALLV 271
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 296 ALcgfAGGVLGGVFSDYLIKRGLSLTLArklpiVLGMLLASTI--ILCNYTNNTTLVVMLMALAFFGKGFGALGWPVISD 373
Cdd:cd17367 272 FM---LLQPLGGRLSDRIGRRPLLLFFG-----IGGTLATVPLlsALDHTDSPYTAFALVLVGLVFLSGYTSINAVVKAE 343
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1487549706 374 TAPKEI----VGLCGGVFN-VFGNVAsivtPLVIGYLVSELHSfNAALVFVGCSALMAMVCYLF 432
Cdd:cd17367 344 LFPTHVralgVGLPYALAVaIFGGTA----PYVALWLKSIGHE-WVFFWYVAGLIAISLVVYLR 402
|
|
| MFS_HMIT_like |
cd17360 |
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ... |
262-433 |
4.66e-03 |
|
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340918 [Multi-domain] Cd Length: 362 Bit Score: 39.18 E-value: 4.66e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 262 INTITWFFLTWFPIYLVQEKGMSILkvglVASIPALCGFAGGVLGGVFSDYLIKRGLSLtlaRKLPIVLGMLLASTIILc 341
Cdd:cd17360 203 INTVMYYSATILQMAGFKDNQNAIW----LSLIVAGTNFIFTIVGMYLIDKFGRRKLLL---ISLFGVIVALVVLAVWL- 274
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 342 nytnntTLVVMLMALAFFGKGFGALGWPVISDTAPKEIVGLCGGVFNVFGNVASIVTPLVIGYLVSELHSFNAALVFVGC 421
Cdd:cd17360 275 ------ALVGLILYLAFFAPGMGPVPWTVNSEIYPLWARGTGGGCAAAVNWVFNLLVSQTFLTLTQAIGPYGTFLLFAGL 348
|
170
....*....|..
gi 1487549706 422 SALMAMVCYLFV 433
Cdd:cd17360 349 AVLGLIFIYFCV 360
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
273-428 |
4.85e-03 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 39.06 E-value: 4.85e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 273 FPIYLVQEKGMSILKVGLVASIPALCGFAGGVLGGVFSDYLIKRGLsltlarkLPIVLGMLLASTIILcnyTNNTTLVVM 352
Cdd:cd17370 221 FLILRAQELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKL-------LILGYLSLALAYLGF---ALGSSLWLL 290
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1487549706 353 LMALAFFGKGFGA---LGWPVISDTAPKEIVGLCGGVFNVFGNVASIVTPLVIGYLVsELHSFNAALVFVGCSALMAMV 428
Cdd:cd17370 291 LLGFILWGLYMGAqesIERAAVADLVPAELRGTAYGLFNTVVGIGWLLASLIAGYLW-DLISPSAAFLFSAVLALIALL 368
|
|
| MFS_DIRC2 |
cd17397 |
Disrupted in renal carcinoma protein 2 of the Major Facilitator Superfamily of transporters; ... |
65-348 |
5.19e-03 |
|
Disrupted in renal carcinoma protein 2 of the Major Facilitator Superfamily of transporters; Disrupted in renal carcinoma protein 2 or disrupted in renal cancer protein 2 (DIRC2), encoded by the SLC49A4 gene, was initially identified as a breakpoint-spanning gene in a chromosomal translocation associated with the development of renal cancer. It is an electrogenic lysosomal metabolite transporter that is regulated by limited proteolytic processing by cathepsin L. DIRC2 belongs to the Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340955 [Multi-domain] Cd Length: 381 Bit Score: 38.82 E-value: 5.19e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 65 AYLLMQIPGGWLLDKFGSKKVYTYSLFFWSLFTFLQGFVdmFPLAWAGISMFFMRFMLGFSEAPSFPANARIVAAWFPTK 144
Cdd:cd17397 51 GFVPTFFFMAWLMDVKGLRIAVLSSAFLVAAGTGLRCIP--VPNHLATWLIHIGQFLNGLAGPVAMAAAPFLSATWFPPN 128
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 145 ERGTASAIFNSAQYFSLA---LFSPL-LGWLTFAWGWEhVFTVMgvigfvltalwikLIHNPTDHPrmsaeelkfiseng 220
Cdd:cd17397 129 QRATATAIASIFNYLGGAasfLIGPLvLMYLEFGWSAL-IFLAM-------------LIYFPSKPP-------------- 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 221 avvdmdhkKPGSAAASGPKLHY---IKQLLSNRMMLGVFFGQYfinTITWFFLTWFPIYLVQEKGMSILKV--GLVASIP 295
Cdd:cd17397 181 --------TPPSVSASTQRLSYksgILSLLKNKRFWLIALAYG---IPTGVYAGWSGVLDVNLTPFGVSQVeaGWIGFYS 249
|
250 260 270 280 290 300 310
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 296 ALCGFAGGVLGGVFSDYLIKR-----------------GLSLTLARKLPIVLGMLLASTIILCNYTNNTT 348
Cdd:cd17397 250 TVAGCVGGIIVGRFADRFGGRmklillllfsgatgsflWFTLICLKLLPFSTVSLYTSCILLGVFLNGSV 319
|
|
| Sugar_tr |
pfam00083 |
Sugar (and other) transporter; |
46-434 |
7.60e-03 |
|
Sugar (and other) transporter;
Pssm-ID: 395036 [Multi-domain] Cd Length: 452 Bit Score: 38.41 E-value: 7.60e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 46 KELQLSAVSMGYIFSAFGWAYLLMQIPGGWLLDKFGSKKVYTYSLFFWSLFTFLQGFVdmfPLAWAGISMFFMRFMLGFS 125
Cdd:pfam00083 39 SSLAALSVLSGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIGAVLQGAA---KGKWSVYQLIVGRVLVGIG 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 126 ---EAPSFPANARIVAawfPTKERGTASAIFNSAQYFSLaLFSPLLGWLT----FAWGWEHVFTVMGVIGFVLTALWIKL 198
Cdd:pfam00083 116 vggASVLAPMYISEIA---PKKLRGALGSLYQLAITFGI-LLAYIFGLGLnktsNSDGWRIPLGLQLVPALLLIIGLLFL 191
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 199 --------IHNPTDHPRMSAEELKfiSENGAVVDMDHKKPGSAAASGPKLHYIKQLLSN-----RMMLGVFFgQYFINTI 265
Cdd:pfam00083 192 pesprwlvEKGRLEEAREVLAKLR--GVPDVDRELDEIKDSLEAGQEAEKASWKELFSTktrrqRLLIGVML-QIFQQLT 268
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 266 TWFFLTWFPIYLVQEKGMSilKVGLVASIPALCGFAGGVLGGVFSDYLIKRGLSLTlarklpIVLGMLLASTIILC---N 342
Cdd:pfam00083 269 GINAIFYYSTTIFENLGLS--DSFLVTIIVGVVNFVFTFIAIFLVDRFGRRPLLLL------GAAGMAICFVILGIvalL 340
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487549706 343 YTNNTTLVVMLMA------LAFFGKGFGALGWPVISDTAPKEIVGLCGGVFNVFGNVASIVTPLVIGYLVSELHSFNAAL 416
Cdd:pfam00083 341 GVSKSDWAGIVAIvfialfIAFFAMGWGPVPWVIVSELFPLSVRSKAMALATAANWLANFLIGFLFPIITDAIGLGYTFF 420
|
410
....*....|....*...
gi 1487549706 417 VFVGCSALMAMVCYLFVV 434
Cdd:pfam00083 421 IFAGLLVLFIIFVFFFVP 438
|
|
| |
