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Conserved domains on  [gi|1487552463|gb|AYG20673|]
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30S ribosomal protein S2 [Escherichia coli str. K-12 substr. MG1655]

Protein Classification

30S ribosomal protein S2( domain architecture ID 10792440)

30S ribosomal protein S2 is an essential component of the translation machinery

Gene Ontology:  GO:0006412|GO:0003735
PubMed:  24524803
SCOP:  4003744

Graphical summary

 Zoom to residue level

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List of domain hits

Name Accession Description Interval E-value
rpsB PRK05299
30S ribosomal protein S2; Provisional
1-241 1.39e-173

30S ribosomal protein S2; Provisional


:

Pssm-ID: 235396  Cd Length: 258  Bit Score: 477.73  E-value: 1.39e-173
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487552463   1 MATVSMRDMLKAGVHFGHQTRYWNPKMKPFIFGARNKVHIINLEKTVPMFNEALAELNKIASRKGKILFVGTKRAASEAV 80
Cdd:PRK05299    1 MAVVSMKQLLEAGVHFGHQTRRWNPKMKPYIFGERNGIHIIDLQKTVPMLDEAYNFVRDVAANGGKILFVGTKKQAQEAI 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487552463  81 KDAALSCDQFFVNHRWLGGMLTNWKTVRQSIKRLKDLETQSQDGTFDKLTKKEALMRTRELEKLENSLGGIKDMGGLPDA 160
Cdd:PRK05299   81 AEEAERCGMPYVNHRWLGGMLTNFKTIRKSIKRLKELEKMEEDGTFEKLTKKEALMLTRELEKLEKSLGGIKDMGGLPDA 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487552463 161 LFVIDADHEHIAIKEANNLGIPVFAIVDTNSDPDGVDFVIPGNDDAIRAVTLYLGAVAATVREGRSQDLASQAEESFVEA 240
Cdd:PRK05299  161 LFVVDPNKEHIAVKEARKLGIPVVAIVDTNCDPDGVDYPIPGNDDAIRSIKLYTSKIADAILEGRQGRLAEAAEEEEEEA 240

                  .
gi 1487552463 241 E 241
Cdd:PRK05299  241 E 241
 
Name Accession Description Interval E-value
rpsB PRK05299
30S ribosomal protein S2; Provisional
1-241 1.39e-173

30S ribosomal protein S2; Provisional


Pssm-ID: 235396  Cd Length: 258  Bit Score: 477.73  E-value: 1.39e-173
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487552463   1 MATVSMRDMLKAGVHFGHQTRYWNPKMKPFIFGARNKVHIINLEKTVPMFNEALAELNKIASRKGKILFVGTKRAASEAV 80
Cdd:PRK05299    1 MAVVSMKQLLEAGVHFGHQTRRWNPKMKPYIFGERNGIHIIDLQKTVPMLDEAYNFVRDVAANGGKILFVGTKKQAQEAI 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487552463  81 KDAALSCDQFFVNHRWLGGMLTNWKTVRQSIKRLKDLETQSQDGTFDKLTKKEALMRTRELEKLENSLGGIKDMGGLPDA 160
Cdd:PRK05299   81 AEEAERCGMPYVNHRWLGGMLTNFKTIRKSIKRLKELEKMEEDGTFEKLTKKEALMLTRELEKLEKSLGGIKDMGGLPDA 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487552463 161 LFVIDADHEHIAIKEANNLGIPVFAIVDTNSDPDGVDFVIPGNDDAIRAVTLYLGAVAATVREGRSQDLASQAEESFVEA 240
Cdd:PRK05299  161 LFVVDPNKEHIAVKEARKLGIPVVAIVDTNCDPDGVDYPIPGNDDAIRSIKLYTSKIADAILEGRQGRLAEAAEEEEEEA 240

                  .
gi 1487552463 241 E 241
Cdd:PRK05299  241 E 241
RpsB COG0052
Ribosomal protein S2 [Translation, ribosomal structure and biogenesis]; Ribosomal protein S2 ...
1-241 1.29e-172

Ribosomal protein S2 [Translation, ribosomal structure and biogenesis]; Ribosomal protein S2 is part of the Pathway/BioSystem: Ribosome 30S subunit


Pssm-ID: 439822  Cd Length: 253  Bit Score: 474.98  E-value: 1.29e-172
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487552463   1 MATVSMRDMLKAGVHFGHQTRYWNPKMKPFIFGARNKVHIINLEKTVPMFNEALAELNKIASRKGKILFVGTKRAASEAV 80
Cdd:COG0052     1 MAVVTMKQLLEAGVHFGHQTRRWNPKMKPYIFGERNGIHIIDLQKTVPLLEEAYNFVRDVAANGGKILFVGTKKQAQEII 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487552463  81 KDAALSCDQFFVNHRWLGGMLTNWKTVRQSIKRLKDLETQSQDGTFDKLTKKEALMRTRELEKLENSLGGIKDMGGLPDA 160
Cdd:COG0052    81 AEEAERCGMPYVNERWLGGMLTNFKTIRKSIKRLKELEKMEEDGTFEKLTKKEALMLRREREKLEKNLGGIKDMKRLPDA 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487552463 161 LFVIDADHEHIAIKEANNLGIPVFAIVDTNSDPDGVDFVIPGNDDAIRAVTLYLGAVAATVREGRSQDLASQAEESFVEA 240
Cdd:COG0052   161 LFVVDPKKEHIAVKEARKLGIPVVAIVDTNCDPDGVDYPIPGNDDAIRSIKLITSKIADAILEGKQGRKAEAEEEEEEAE 240

                  .
gi 1487552463 241 E 241
Cdd:COG0052   241 E 241
rpsB_bact TIGR01011
ribosomal protein S2, bacterial type; This model describes the bacterial, ribosomal, and ...
3-227 3.34e-150

ribosomal protein S2, bacterial type; This model describes the bacterial, ribosomal, and chloroplast forms of ribosomal protein S2. TIGR01012 describes the archaeal and cytosolic forms. [Protein synthesis, Ribosomal proteins: synthesis and modification]


Pssm-ID: 130084  Cd Length: 225  Bit Score: 417.11  E-value: 3.34e-150
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487552463   3 TVSMRDMLKAGVHFGHQTRYWNPKMKPFIFGARNKVHIINLEKTVPMFNEALAELNKIASRKGKILFVGTKRAASEAVKD 82
Cdd:TIGR01011   1 VVSMKDLLEAGVHFGHQTRRWNPKMKPFIFGERNGIHIIDLQKTLQLLKEAYNFVKDVAANGGKILFVGTKKQAKEIIKE 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487552463  83 AALSCDQFFVNHRWLGGMLTNWKTVRQSIKRLKDLETQSQDGTFDKLTKKEALMRTRELEKLENSLGGIKDMGGLPDALF 162
Cdd:TIGR01011  81 EAERCGMFYVNQRWLGGMLTNFKTIRKSIKKLKKLEKMEEDGTFDDLTKKEALMLSREKEKLEKSLGGIKDMKKLPDLLF 160
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1487552463 163 VIDADHEHIAIKEANNLGIPVFAIVDTNSDPDGVDFVIPGNDDAIRAVTLYLGAVAATVREGRSQ 227
Cdd:TIGR01011 161 VIDPVKEKIAVAEARKLGIPVVAIVDTNCDPDLVDYPIPGNDDAIRSIRLLTNLIADAVLEGKQE 225
Ribosomal_S2 pfam00318
Ribosomal protein S2;
9-224 9.24e-144

Ribosomal protein S2;


Pssm-ID: 459759  Cd Length: 216  Bit Score: 400.66  E-value: 9.24e-144
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487552463   9 MLKAGVHFGHQTRYWNPKMKPFIFGARNKVHIINLEKTVPMFNEALAELNKIASRKGKILFVGTKRAASEAVKDAALSCD 88
Cdd:pfam00318   1 LLEAGVHFGHQTRRWNPKMKPYIFGERNGIHIIDLEKTLPLLRRAYKVVREVAAKGGKILFVGTKKQAQEAIKEAAKRCG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487552463  89 QFFVNHRWLGGMLTNWKTVRQSIKRLKDLETQSQDGTFDKLTKKEALMRTRELEKLENSLGGIKDMGGLPDALFVIDADH 168
Cdd:pfam00318  81 MYYVNERWLGGMLTNFKTIRKSIKRLKELEEMEEDGTFEDLTKKEALTLKREREKLEKNLGGIKDMKRLPDLLFVLDPNK 160
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1487552463 169 EHIAIKEANNLGIPVFAIVDTNSDPDGVDFVIPGNDDAIRAVTLYLGAVAATVREG 224
Cdd:pfam00318 161 EKIAVKEARKLGIPVIGIVDTNCDPDLVDYPIPGNDDAIRSIKLILGVLADAIIEG 216
RPS2 cd01425
Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, ...
9-223 2.07e-106

Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of ribosomal protein S1 to the 30s ribosomal subunit. In humans, most likely in all vertebrates, and perhaps in all metazoans, the protein also functions as the 67 kDa laminin receptor (LAMR1 or 67LR), which is formed from a 37 kDa precursor, and is overexpressed in many tumors. 67LR is a cell surface receptor which interacts with a variety of ligands, laminin-1 and others. It is assumed that the ligand interactions are mediated via the conserved C-terminus, which becomes extracellular as the protein undergoes conformational changes which are not well understood. Specifically, a conserved palindromic motif, LMWWML, may participate in the interactions. 67LR plays essential roles in the adhesion of cells to the basement membrane and subsequent signalling events, and has been linked to several diseases. Some evidence also suggests that the precursor of 67LR, 37LRP is also present in the nucleus in animals, where it appears associated with histones.


Pssm-ID: 100106  Cd Length: 193  Bit Score: 305.28  E-value: 2.07e-106
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487552463   9 MLKAGVHFGHQTRYWNPKMKPFIFGARNKVHIINLEKTVPMFNEALAELNKIASRKGKILFVGTKRAASEAVKDAALSCD 88
Cdd:cd01425     1 LLEAGVHLGHKTRRWNPKMKPYIYGERNGIHIIDLEKTLEKLRLALNFIANIAAKGGKILFVGTKPQAQRAVKKFAERTG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487552463  89 QFFVNHRWLGGMLTNWKTVRQSIKRLKDLETqsqdgtfdkltkkealmrtrelEKLENSLGGIKDMGGLPDALFVIDADH 168
Cdd:cd01425    81 SFYVNGRWLGGTLTNWKTIRKSIKRLKKLEK----------------------EKLEKNLGGIKDMFRLPDLVIVLDPRK 138
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1487552463 169 EHIAIKEANNLGIPVFAIVDTNSDPDGVDFVIPGNDDAIRAVTLYLGAVAATVRE 223
Cdd:cd01425   139 EHQAIREASKLGIPVIAIVDTNCDPDLIDYPIPANDDSIRSIALILWLLARAILE 193
 
Name Accession Description Interval E-value
rpsB PRK05299
30S ribosomal protein S2; Provisional
1-241 1.39e-173

30S ribosomal protein S2; Provisional


Pssm-ID: 235396  Cd Length: 258  Bit Score: 477.73  E-value: 1.39e-173
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487552463   1 MATVSMRDMLKAGVHFGHQTRYWNPKMKPFIFGARNKVHIINLEKTVPMFNEALAELNKIASRKGKILFVGTKRAASEAV 80
Cdd:PRK05299    1 MAVVSMKQLLEAGVHFGHQTRRWNPKMKPYIFGERNGIHIIDLQKTVPMLDEAYNFVRDVAANGGKILFVGTKKQAQEAI 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487552463  81 KDAALSCDQFFVNHRWLGGMLTNWKTVRQSIKRLKDLETQSQDGTFDKLTKKEALMRTRELEKLENSLGGIKDMGGLPDA 160
Cdd:PRK05299   81 AEEAERCGMPYVNHRWLGGMLTNFKTIRKSIKRLKELEKMEEDGTFEKLTKKEALMLTRELEKLEKSLGGIKDMGGLPDA 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487552463 161 LFVIDADHEHIAIKEANNLGIPVFAIVDTNSDPDGVDFVIPGNDDAIRAVTLYLGAVAATVREGRSQDLASQAEESFVEA 240
Cdd:PRK05299  161 LFVVDPNKEHIAVKEARKLGIPVVAIVDTNCDPDGVDYPIPGNDDAIRSIKLYTSKIADAILEGRQGRLAEAAEEEEEEA 240

                  .
gi 1487552463 241 E 241
Cdd:PRK05299  241 E 241
RpsB COG0052
Ribosomal protein S2 [Translation, ribosomal structure and biogenesis]; Ribosomal protein S2 ...
1-241 1.29e-172

Ribosomal protein S2 [Translation, ribosomal structure and biogenesis]; Ribosomal protein S2 is part of the Pathway/BioSystem: Ribosome 30S subunit


Pssm-ID: 439822  Cd Length: 253  Bit Score: 474.98  E-value: 1.29e-172
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487552463   1 MATVSMRDMLKAGVHFGHQTRYWNPKMKPFIFGARNKVHIINLEKTVPMFNEALAELNKIASRKGKILFVGTKRAASEAV 80
Cdd:COG0052     1 MAVVTMKQLLEAGVHFGHQTRRWNPKMKPYIFGERNGIHIIDLQKTVPLLEEAYNFVRDVAANGGKILFVGTKKQAQEII 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487552463  81 KDAALSCDQFFVNHRWLGGMLTNWKTVRQSIKRLKDLETQSQDGTFDKLTKKEALMRTRELEKLENSLGGIKDMGGLPDA 160
Cdd:COG0052    81 AEEAERCGMPYVNERWLGGMLTNFKTIRKSIKRLKELEKMEEDGTFEKLTKKEALMLRREREKLEKNLGGIKDMKRLPDA 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487552463 161 LFVIDADHEHIAIKEANNLGIPVFAIVDTNSDPDGVDFVIPGNDDAIRAVTLYLGAVAATVREGRSQDLASQAEESFVEA 240
Cdd:COG0052   161 LFVVDPKKEHIAVKEARKLGIPVVAIVDTNCDPDGVDYPIPGNDDAIRSIKLITSKIADAILEGKQGRKAEAEEEEEEAE 240

                  .
gi 1487552463 241 E 241
Cdd:COG0052   241 E 241
rpsB_bact TIGR01011
ribosomal protein S2, bacterial type; This model describes the bacterial, ribosomal, and ...
3-227 3.34e-150

ribosomal protein S2, bacterial type; This model describes the bacterial, ribosomal, and chloroplast forms of ribosomal protein S2. TIGR01012 describes the archaeal and cytosolic forms. [Protein synthesis, Ribosomal proteins: synthesis and modification]


Pssm-ID: 130084  Cd Length: 225  Bit Score: 417.11  E-value: 3.34e-150
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487552463   3 TVSMRDMLKAGVHFGHQTRYWNPKMKPFIFGARNKVHIINLEKTVPMFNEALAELNKIASRKGKILFVGTKRAASEAVKD 82
Cdd:TIGR01011   1 VVSMKDLLEAGVHFGHQTRRWNPKMKPFIFGERNGIHIIDLQKTLQLLKEAYNFVKDVAANGGKILFVGTKKQAKEIIKE 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487552463  83 AALSCDQFFVNHRWLGGMLTNWKTVRQSIKRLKDLETQSQDGTFDKLTKKEALMRTRELEKLENSLGGIKDMGGLPDALF 162
Cdd:TIGR01011  81 EAERCGMFYVNQRWLGGMLTNFKTIRKSIKKLKKLEKMEEDGTFDDLTKKEALMLSREKEKLEKSLGGIKDMKKLPDLLF 160
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1487552463 163 VIDADHEHIAIKEANNLGIPVFAIVDTNSDPDGVDFVIPGNDDAIRAVTLYLGAVAATVREGRSQ 227
Cdd:TIGR01011 161 VIDPVKEKIAVAEARKLGIPVVAIVDTNCDPDLVDYPIPGNDDAIRSIRLLTNLIADAVLEGKQE 225
Ribosomal_S2 pfam00318
Ribosomal protein S2;
9-224 9.24e-144

Ribosomal protein S2;


Pssm-ID: 459759  Cd Length: 216  Bit Score: 400.66  E-value: 9.24e-144
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487552463   9 MLKAGVHFGHQTRYWNPKMKPFIFGARNKVHIINLEKTVPMFNEALAELNKIASRKGKILFVGTKRAASEAVKDAALSCD 88
Cdd:pfam00318   1 LLEAGVHFGHQTRRWNPKMKPYIFGERNGIHIIDLEKTLPLLRRAYKVVREVAAKGGKILFVGTKKQAQEAIKEAAKRCG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487552463  89 QFFVNHRWLGGMLTNWKTVRQSIKRLKDLETQSQDGTFDKLTKKEALMRTRELEKLENSLGGIKDMGGLPDALFVIDADH 168
Cdd:pfam00318  81 MYYVNERWLGGMLTNFKTIRKSIKRLKELEEMEEDGTFEDLTKKEALTLKREREKLEKNLGGIKDMKRLPDLLFVLDPNK 160
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1487552463 169 EHIAIKEANNLGIPVFAIVDTNSDPDGVDFVIPGNDDAIRAVTLYLGAVAATVREG 224
Cdd:pfam00318 161 EKIAVKEARKLGIPVIGIVDTNCDPDLVDYPIPGNDDAIRSIKLILGVLADAIIEG 216
rpsB PRK12311
30S ribosomal protein S2;
6-227 6.47e-112

30S ribosomal protein S2;


Pssm-ID: 183428 [Multi-domain]  Cd Length: 326  Bit Score: 324.03  E-value: 6.47e-112
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487552463   6 MRDMLKAGVHFGHQTRYWNPKMKPFIFGARNKVHIINLEKTVPMFNEALAELNKIASRKGKILFVGTKRAASEAVKDAAL 85
Cdd:PRK12311    1 MRQLLEAGVHFGHQSHRWNPKMAPYIFGTRNNIHIIDLAQTVPLLHRALQAVSDTVAKGGRVLFVGTKRQAQDAVADAAK 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487552463  86 SCDQFFVNHRWLGGMLTNWKTVRQSIKRLKDLETQSQDGTFDKLTKKEALMRTRELEKLENSLGGIKDMGGLPDALFVID 165
Cdd:PRK12311   81 RSAQYFVNSRWLGGTLTNWKTISGSIQRLRKLDEVLSSGEANGYTKKERLTLQRERDKLDRALGGIKDMGGLPDLLFVID 160
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1487552463 166 ADHEHIAIKEANNLGIPVFAIVDTNSDPDGVDFVIPGNDDAIRAVTLYLGAVAATVREG--RSQ 227
Cdd:PRK12311  161 TNKEDIAIQEAQRLGIPVAAIVDTNCDPDGITYPVPGNDDAGRAIALYCDLIARAAIDGisRAQ 224
rps2 CHL00067
ribosomal protein S2
1-226 1.91e-107

ribosomal protein S2


Pssm-ID: 177007  Cd Length: 230  Bit Score: 309.09  E-value: 1.91e-107
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487552463   1 MATVSMRDMLKAGVHFGHQTRYWNPKMKPFIFGARNKVHIINLEKTVPMFNEALAELNKIASRKGKILFVGTKRAASEAV 80
Cdd:CHL00067    5 MWNINLEEMLEAGVHFGHQTRKWNPKMAPYIYAERNGIHIINLVQTARFLSEACDLVFDAASKGKKFLFVGTKKQAADLV 84
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487552463  81 KDAALSCDQFFVNHRWLGGMLTNWKTVRQSIKRLKDLETQSQDGTFDKLTKKEALMRTRELEKLENSLGGIKDMGGLPDA 160
Cdd:CHL00067   85 ASAAIRARCHYVNKRWLGGMLTNWSTTKTRLQKLRDLRMEEKTGLFNRLPKKEAAILKRQLSRLEKYLGGIKYMTKLPDI 164
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1487552463 161 LFVIDADHEHIAIKEANNLGIPVFAIVDTNSDPDGVDFVIPGNDDAIRAVTLYLGAVAATVREGRS 226
Cdd:CHL00067  165 VIIIDQQEEYTALRECRKLGIPTISILDTNCDPDLADIPIPANDDAIASIKLILNKLTTAICEGRS 230
RPS2 cd01425
Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, ...
9-223 2.07e-106

Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of ribosomal protein S1 to the 30s ribosomal subunit. In humans, most likely in all vertebrates, and perhaps in all metazoans, the protein also functions as the 67 kDa laminin receptor (LAMR1 or 67LR), which is formed from a 37 kDa precursor, and is overexpressed in many tumors. 67LR is a cell surface receptor which interacts with a variety of ligands, laminin-1 and others. It is assumed that the ligand interactions are mediated via the conserved C-terminus, which becomes extracellular as the protein undergoes conformational changes which are not well understood. Specifically, a conserved palindromic motif, LMWWML, may participate in the interactions. 67LR plays essential roles in the adhesion of cells to the basement membrane and subsequent signalling events, and has been linked to several diseases. Some evidence also suggests that the precursor of 67LR, 37LRP is also present in the nucleus in animals, where it appears associated with histones.


Pssm-ID: 100106  Cd Length: 193  Bit Score: 305.28  E-value: 2.07e-106
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487552463   9 MLKAGVHFGHQTRYWNPKMKPFIFGARNKVHIINLEKTVPMFNEALAELNKIASRKGKILFVGTKRAASEAVKDAALSCD 88
Cdd:cd01425     1 LLEAGVHLGHKTRRWNPKMKPYIYGERNGIHIIDLEKTLEKLRLALNFIANIAAKGGKILFVGTKPQAQRAVKKFAERTG 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487552463  89 QFFVNHRWLGGMLTNWKTVRQSIKRLKDLETqsqdgtfdkltkkealmrtrelEKLENSLGGIKDMGGLPDALFVIDADH 168
Cdd:cd01425    81 SFYVNGRWLGGTLTNWKTIRKSIKRLKKLEK----------------------EKLEKNLGGIKDMFRLPDLVIVLDPRK 138
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1487552463 169 EHIAIKEANNLGIPVFAIVDTNSDPDGVDFVIPGNDDAIRAVTLYLGAVAATVRE 223
Cdd:cd01425   139 EHQAIREASKLGIPVIAIVDTNCDPDLIDYPIPANDDSIRSIALILWLLARAILE 193
uS2_euk_arch TIGR01012
ribosomal protein uS2, eukaryotic/archaeal form; This model describes the ribosomal protein of ...
4-212 3.15e-12

ribosomal protein uS2, eukaryotic/archaeal form; This model describes the ribosomal protein of the cytosol and of Archaea, homologous to S2 of bacteria. It is designated typically as Sa in eukaryotes and Sa or S2 in the archaea. TIGR01011 describes the related protein of organelles and bacteria. [Protein synthesis, Ribosomal proteins: synthesis and modification]


Pssm-ID: 273394  Cd Length: 196  Bit Score: 63.22  E-value: 3.15e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487552463   4 VSMRDMLKAGVHFGHQTRywNPKMKPFIFGARNK-VHIINLEKTvpmfNEALAELNKIASR--KGKILFVGTKRAASEAV 80
Cdd:TIGR01012   4 VPVDMYLAAGVHIGTQNK--TFDMEKFIYKVRQDgLYVLDLRKT----DERLRVAAKFLVAiePQDILVVSARIYGQKPV 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487552463  81 KDAALSCDQFFVNHRWLGGMLTNwktvrqsikrlkdletQSQDGTFDkltkkealmrtreleklenslggikdmgglPDA 160
Cdd:TIGR01012  78 LKFAKVTGARAIAGRFTPGTFTN----------------PAQKSFRE------------------------------PRV 111
                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1487552463 161 LFVIDADHEHIAIKEANNLGIPVFAIVDTNSDPDGVDFVIPGNDDAIRAVTL 212
Cdd:TIGR01012 112 LIVTDPRADHQAVKEASEVGIPIVALCDTDNPLRYVDLVIPTNNKGRRSLAL 163
PTZ00254 PTZ00254
40S ribosomal protein SA; Provisional
5-203 1.82e-07

40S ribosomal protein SA; Provisional


Pssm-ID: 240331 [Multi-domain]  Cd Length: 249  Bit Score: 50.44  E-value: 1.82e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487552463   5 SMRDMLKAGVHFGhqTRYWNPKMKPFIFG-ARNKVHIINLEKTVpmfnealaELNKIASR-------KGKILFVGTKRAA 76
Cdd:PTZ00254   14 DIKKMLACKCHIG--TKNLENAMKKYVYKrTKEGVHIINLAKTW--------EKLKLAARviaaienPADVVVVSSRPYG 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1487552463  77 SEAV-KDAALSCDQFFVNhRWLGGMLTNwktvrqsikrlkdletqsqdgtfdKLTKKeaLMRtreleklenslggikdmg 155
Cdd:PTZ00254   84 QRAVlKFAQYTGASAIAG-RFTPGTFTN------------------------QIQKK--FME------------------ 118
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 1487552463 156 glPDALFVIDADHEHIAIKEANNLGIPVFAIVDTNSDPDGVDFVIPGN 203
Cdd:PTZ00254  119 --PRLLIVTDPRTDHQAIREASYVNIPVIALCDTDSPLEYVDIAIPCN 164
PurR COG1609
DNA-binding transcriptional regulator, LacI/PurR family [Transcription];
158-214 2.21e-03

DNA-binding transcriptional regulator, LacI/PurR family [Transcription];


Pssm-ID: 441217 [Multi-domain]  Cd Length: 335  Bit Score: 38.64  E-value: 2.21e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1487552463 158 PDALFVIDADHEHIAIKEANNLGIPVfAIVDTNSDPDGVDFVIPGNDDAIRAVTLYL 214
Cdd:COG1609   118 VDGLILAGSRLDDARLERLAEAGIPV-VLIDRPLPDPGVPSVGVDNRAGARLATEHL 173
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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