|
Name |
Accession |
Description |
Interval |
E-value |
| PRK06814 |
PRK06814 |
acyl-[ACP]--phospholipid O-acyltransferase; |
3-590 |
2.27e-156 |
|
acyl-[ACP]--phospholipid O-acyltransferase;
Pssm-ID: 235865 [Multi-domain] Cd Length: 1140 Bit Score: 479.08 E-value: 2.27e-156
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524484190 3 HPSQFTLLRTRRFLPFFITQLLGAFNDNIFKQSLILAILYKL--TLDGDRSIWVNLCALLFILPFFLFSALAGQFGEKFN 80
Cdd:PRK06814 1 DTMKLYLMKSRRFAPLFWTQFFGAFNDNFLKNALVILILYGLsgALGAYNNALVTLAGAVFILPFFIFSALAGQLADKYD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524484190 81 KDALIRAIKLGEIVIMAVGATGFLFDHLELMLLALFAMGTHSALFGPVKYSIMPQALHDDELVGGNGLVEMGTFLAILAG 160
Cdd:PRK06814 81 KAKLAKILKFAEIGIAALAIYGFHLNSVPLLFAALFLMGIHSALFGPIKYSILPDHLNKDELLGANALVEAGTFIAILLG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524484190 161 TIGAGIMMSStHYAPVVAVAIVGVALLGYLASRSIPRAAASTPQLRLDWNIFTQSWATLRMgLGQTPAVSRSIVGNSWFW 240
Cdd:PRK06814 161 TIIGGLATIS-GNFVILVALLMGIAVLGWLASLFIPKTGNAAPDLKIDRNIIRSTITLLKY-AKADKRIWLAILGISWFW 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524484190 241 FVGAIYLTQIPAYAKEWLYGDETVVTLILTVFSVGIALGSMLCEKLSGRKVEIGLVPFGSFGLTVFGLLLWWHSGGFVQN 320
Cdd:PRK06814 239 LVGAVVLSQLPLLAKETLGGDENVATLFLAVFSVGVAVGSFLASKLSEGRITLLYVPIGALLMGLFGLDLAFASSSVPAE 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524484190 321 V-QPNDWLAVLGYGQAWWVLFDILGLGVFGGFYIVPLYALIQSRTAENQRARVIAANNILNALFMVVSAIVSILLLSvAK 399
Cdd:PRK06814 319 PaQLKSILVFLSKRHGWRILIDLFGLAAAGGLYIVPLFAALQAWANPAHRARVIAANNVLNAAFMVAGTIILALLQA-LG 397
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524484190 400 LSIPELFLVVSLLNIAVNTYIFRIVPEFTMRFMIWLLSHSMYRVEHRNLEQIPDEG-AALLVCNHVSFVDALLIGGAVRR 478
Cdd:PRK06814 398 FSIPWIILFIALANLIVAILILRLLPTNLLRDIFSILFRAFYRVEVKGLENLQKAGkKAVIAANHVSFLDGPLLAAYLPE 477
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524484190 479 PIRFVMYYKIYRL----PVLnfifRTAGAIPI------AGRHediqiyekaftrIAKYLKDGELVCIFPEGKLTGDGEMN 548
Cdd:PRK06814 478 EPTFAIDTDIAKAwwvkPFL----KLAKALPVdptnpmATRT------------LIKEVQKGEKLVIFPEGRITVTGSLM 541
|
570 580 590 600
....*....|....*....|....*....|....*....|....*
gi 1524484190 549 EFRGGVTRILEETPVPVIPMALQGLWGSFFSR---DPDKGLFHRI 590
Cdd:PRK06814 542 KIYDGPGMIADKAGAMVVPVRIDGLQFTHFSRlknQVRRKWFPKV 586
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
15-423 |
8.89e-48 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 172.03 E-value: 8.89e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524484190 15 FLPFFITQLLGAFNDNIFKQSLILAILYKltldGDRSIWVNLCALLFILPFFLFSALAGQFGEKFNKDALIRAIKLGEIV 94
Cdd:cd06173 1 FRLLWLAQLLSALGDWIFTVALPWLVLQL----TGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRAL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524484190 95 IMAVGATGFLFDHLEL--MLLALFAMGTHSALFGPVKYSIMPQALHDDELVGGNGLVEMGTFLAILAGTIGAGIMMSSTH 172
Cdd:cd06173 77 LAAVLALLALLGSLSLwlLLVLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLG 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524484190 173 yAPVVAVAIVGVALLGYLASRSIPRAAASTPQLRLDWNIftQSWATLRMGLGQTPAVSRSIVGNSWFWFVGAIYLTQIPA 252
Cdd:cd06173 157 -PGGAFAINALSFLLSALLLLFIRRPPPAAPGESSSLLL--RDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPL 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524484190 253 YAKEWLYGDETVVTLILTVFSVGIALGSMLCEKLSGRKVEIGLVPFGSFGLTVFGLLLWWHSggfvqnvqpndwlavlgy 332
Cdd:cd06173 234 LAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSP------------------ 295
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524484190 333 gQAWWVLFDILGLGVFGGFYIVPLYALIQSRTAENQRARVIAANNILNALFMVVSAIVSILLLsvAKLSIPELFLVVSLL 412
Cdd:cd06173 296 -SLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLA--DALGLSAVFLLAGAL 372
|
410
....*....|.
gi 1524484190 413 NIAVNTYIFRI 423
Cdd:cd06173 373 LLLAALLLLLL 383
|
|
| PlsC |
COG0204 |
1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; ... |
418-624 |
1.61e-42 |
|
1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; 1-acyl-sn-glycerol-3-phosphate acyltransferase is part of the Pathway/BioSystem: Phospholipid biosynthesis
Pssm-ID: 439974 [Multi-domain] Cd Length: 215 Bit Score: 152.47 E-value: 1.61e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524484190 418 TYIFRIVPEFTMRFMIWLLSHSM-YRVEHRNLEQIPDEGAALLVCNHVSFVDALLIGGAVRRPIRFVMYYKIYRLPVLNF 496
Cdd:COG0204 5 FLLLRRFRYRLVRLWARLLLRLLgVRVRVEGLENLPADGPVLIVANHQSWLDILLLLAALPRPVRFVAKKELFKIPLLGW 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524484190 497 IFRTAGAIPI--AGRHEDIqiyeKAFTRIAKYLKDGELVCIFPEGKLTGDGEMNEFRGGVTRILEETPVPVIPMALQGLW 574
Cdd:COG0204 85 LLRALGAIPVdrSKRRAAL----RALRQAVEALKAGESLVIFPEGTRSPDGRLLPFKTGAARLALEAGVPIVPVAIDGTE 160
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 1524484190 575 GSFFsrdpdKGLFHRIwSRVVLVAGAPVPVEEATPAQLQAVVGVLRGSVR 624
Cdd:COG0204 161 RALP-----KGFLPRP-GKVTVRIGPPIDPSDLEGEDRRELAERLRAAIE 204
|
|
| Acyltransferase |
pfam01553 |
Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis ... |
442-570 |
6.92e-24 |
|
Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis and other proteins of unknown function. This family also includes tafazzin, the Barth syndrome gene.
Pssm-ID: 366704 [Multi-domain] Cd Length: 131 Bit Score: 97.35 E-value: 6.92e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524484190 442 RVEHRNLEQIPDEGAALLVCNHVSFVDALLIGGAV---RRPIRFVMYYKIYRLPVLNFIFRTAGAIPIagRHEDIQIYEK 518
Cdd:pfam01553 1 RIEVHGLENLPRGGPAIVVANHQSYLDVLLLSLALykrGRPLVFVAKKELFDIPLVGWLMRLLGCIFI--DRKNRKDAAG 78
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 1524484190 519 AFTRIAKYLKDGELVCIFPEGKLTGDGEMNEFRGGVTRILEETPVPVIPMAL 570
Cdd:pfam01553 79 TLEYLVELLREGKLVVIFPEGTRSREGELLPFKKGAFRLAIEAGVPIVPVAI 130
|
|
| PlsC |
smart00563 |
Phosphate acyltransferases; Function in phospholipid biosynthesis and have either ... |
457-573 |
1.15e-22 |
|
Phosphate acyltransferases; Function in phospholipid biosynthesis and have either glycerolphosphate, 1-acylglycerolphosphate, or 2-acylglycerolphosphoethanolamine acyltransferase activities. Tafazzin, the product of the gene mutated in patients with Barth syndrome, is a member of this family.
Pssm-ID: 214724 [Multi-domain] Cd Length: 118 Bit Score: 93.57 E-value: 1.15e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524484190 457 ALLVCNHVSFVDALLIGGAVRR---PIRFVMYYKIYRLPVLNFIFRTAGAIPIagRHEDIQIYEKAFTRIAKYLKDGELV 533
Cdd:smart00563 1 ALVVANHQSFLDPLVLSALLPRklgRVRFVAKKELFYVPLLGWLLRLLGAIFI--DRSNGRKARAALREAVELLKEGEWL 78
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 1524484190 534 CIFPEGKLTGDGEMNEFRGGVTRILEETPVPVIPMALQGL 573
Cdd:smart00563 79 LIFPEGTRSRPGKLLPFKKGAARLALEAGVPIVPVAIRGT 118
|
|
| AGP_acyltrn |
TIGR00530 |
1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous ... |
443-571 |
7.33e-18 |
|
1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous region of a collection of related proteins, several of which are known to act as 1-acyl-sn-glycerol-3-phosphate acyltransferases (EC 2.3.1.51). Proteins scoring above the trusted cutoff are likely to have the same general activity. However, there is variation among characterized members as to whether the acyl group can be donated by acyl carrier protein or coenzyme A, and in the length and saturation of the donated acyl group. 1-acyl-sn-glycerol-3-phosphate acyltransferase is also called 1-AGP acyltransferase, lysophosphatidic acid acyltransferase, and LPA acyltransferase. [Fatty acid and phospholipid metabolism, Biosynthesis]
Pssm-ID: 129621 [Multi-domain] Cd Length: 130 Bit Score: 80.08 E-value: 7.33e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524484190 443 VEHRNLEQIPDEGAALLVCNHVSFVDALLIGGAVRRPIRFVMYYKIYRLPVLNFIFRTAGAIPIagRHEDIQIYEKAFTR 522
Cdd:TIGR00530 4 VEVVGPENLPAKSPVLVVANHQSNLDPLTLSAAFPPPIVFIAKKELKWIPFFGIMLWLTGAIFI--DRENIRAIATALKA 81
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 1524484190 523 IAKYLKDGELVCIFPEGKLTGDGEMNEFRGGVTRILEETPVPVIPMALQ 571
Cdd:TIGR00530 82 AIEVLKQGRSIGVFPEGTRSRGRDILPFKKGAFHIAIKAGVPILPVVLS 130
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PRK06814 |
PRK06814 |
acyl-[ACP]--phospholipid O-acyltransferase; |
3-590 |
2.27e-156 |
|
acyl-[ACP]--phospholipid O-acyltransferase;
Pssm-ID: 235865 [Multi-domain] Cd Length: 1140 Bit Score: 479.08 E-value: 2.27e-156
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524484190 3 HPSQFTLLRTRRFLPFFITQLLGAFNDNIFKQSLILAILYKL--TLDGDRSIWVNLCALLFILPFFLFSALAGQFGEKFN 80
Cdd:PRK06814 1 DTMKLYLMKSRRFAPLFWTQFFGAFNDNFLKNALVILILYGLsgALGAYNNALVTLAGAVFILPFFIFSALAGQLADKYD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524484190 81 KDALIRAIKLGEIVIMAVGATGFLFDHLELMLLALFAMGTHSALFGPVKYSIMPQALHDDELVGGNGLVEMGTFLAILAG 160
Cdd:PRK06814 81 KAKLAKILKFAEIGIAALAIYGFHLNSVPLLFAALFLMGIHSALFGPIKYSILPDHLNKDELLGANALVEAGTFIAILLG 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524484190 161 TIGAGIMMSStHYAPVVAVAIVGVALLGYLASRSIPRAAASTPQLRLDWNIFTQSWATLRMgLGQTPAVSRSIVGNSWFW 240
Cdd:PRK06814 161 TIIGGLATIS-GNFVILVALLMGIAVLGWLASLFIPKTGNAAPDLKIDRNIIRSTITLLKY-AKADKRIWLAILGISWFW 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524484190 241 FVGAIYLTQIPAYAKEWLYGDETVVTLILTVFSVGIALGSMLCEKLSGRKVEIGLVPFGSFGLTVFGLLLWWHSGGFVQN 320
Cdd:PRK06814 239 LVGAVVLSQLPLLAKETLGGDENVATLFLAVFSVGVAVGSFLASKLSEGRITLLYVPIGALLMGLFGLDLAFASSSVPAE 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524484190 321 V-QPNDWLAVLGYGQAWWVLFDILGLGVFGGFYIVPLYALIQSRTAENQRARVIAANNILNALFMVVSAIVSILLLSvAK 399
Cdd:PRK06814 319 PaQLKSILVFLSKRHGWRILIDLFGLAAAGGLYIVPLFAALQAWANPAHRARVIAANNVLNAAFMVAGTIILALLQA-LG 397
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524484190 400 LSIPELFLVVSLLNIAVNTYIFRIVPEFTMRFMIWLLSHSMYRVEHRNLEQIPDEG-AALLVCNHVSFVDALLIGGAVRR 478
Cdd:PRK06814 398 FSIPWIILFIALANLIVAILILRLLPTNLLRDIFSILFRAFYRVEVKGLENLQKAGkKAVIAANHVSFLDGPLLAAYLPE 477
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524484190 479 PIRFVMYYKIYRL----PVLnfifRTAGAIPI------AGRHediqiyekaftrIAKYLKDGELVCIFPEGKLTGDGEMN 548
Cdd:PRK06814 478 EPTFAIDTDIAKAwwvkPFL----KLAKALPVdptnpmATRT------------LIKEVQKGEKLVIFPEGRITVTGSLM 541
|
570 580 590 600
....*....|....*....|....*....|....*....|....*
gi 1524484190 549 EFRGGVTRILEETPVPVIPMALQGLWGSFFSR---DPDKGLFHRI 590
Cdd:PRK06814 542 KIYDGPGMIADKAGAMVVPVRIDGLQFTHFSRlknQVRRKWFPKV 586
|
|
| PRK08633 |
PRK08633 |
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated |
8-616 |
2.22e-143 |
|
2-acyl-glycerophospho-ethanolamine acyltransferase; Validated
Pssm-ID: 236315 [Multi-domain] Cd Length: 1146 Bit Score: 445.14 E-value: 2.22e-143
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524484190 8 TLLRTRRFLPFFITQLLGAFNDNIFKqSLILAILYKlTLDGDRSIWVNLCALLFILP-FFLFSALAGQFGEKFNKDALIR 86
Cdd:PRK08633 4 NLLKIIGFLPLLLTQFLNAFNDLGHK-ILIQNTLIK-AYDGSEQVILTAIVNALFLLpFLLLSSPAGFLADKFSKNRVIR 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524484190 87 AIKLGEIVIMAVGATGFLFDHLELMLLALFAMGTHSALFGPVKYSIMPQALHDDELVGGNGLVEMGTFLAILAGTIGAGI 166
Cdd:PRK08633 82 IVKLFEVGLTLLIVLAYYLGWFWLAFAVTFLLGAQSAIYSPAKYGIIPELVGKENLSRANGLLEAFTIVAILAGTALFSF 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524484190 167 MMSST---------HYAPVVAVAIVGVALLGYLASRSIPR--AAASTPQLRLDWNIFTQSWATLRMgLGQTPAVSRSIVG 235
Cdd:PRK08633 162 LFESVngntpseilGRIAPAGLVLLAVAVLGLIFAYRLPKvpAAAPEVFDKKKYLFPKLLWRNLKL-LRSDRVLWLAIIG 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524484190 236 NSWFWFVGAIYLTQIPAYAKEWLYGDET-VVTLILTVFSVGIALGSMLCEKLSGRKVEIGLVPFGSFGLTVFGLLLwwhs 314
Cdd:PRK08633 241 LSYFWFISQLAQANFPAYAKEVLGLDNTfQVQYLLAASAIGIGIGSLLAGRLSGRHIELGLVPLGALGLALSLFLL---- 316
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524484190 315 gGFVQNVqpndwlavlgygqaWWVLFDILGLGVFGGFYIVPLYALIQSRTAENQRARVIAANNILNALFMVVSAIVSILL 394
Cdd:PRK08633 317 -PTAPSL--------------ASVLVLFFLFGFSAGLFIVPLNALIQFRAPEKELGKVLAANNFLQNVGMLLFLALTTLF 381
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524484190 395 lSVAKLSIPELFLVVSLLNIAVNTYIFRIVPEFTMRFMIWLLSHSMYRVEHRNLEQIPDEGAALLVCNHVSFVDALLIGG 474
Cdd:PRK08633 382 -SGLGLSPAGLFYLIALVTLIGTLYTLLLLPDSLLRFLLLLLMHTRYRLRVEGRENIPAKGGALLLGNHVSWIDWALLQA 460
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524484190 475 AVRRPIRFVMYYKIYRLPVLNFIFRTAGAIPI--AGRHEDIQIyekaftrIAKYLKDGELVCIFPEGKLTGDGEMNEFRG 552
Cdd:PRK08633 461 ASPRPIRFVMERSIYEKWYLKWFFKLFGVIPIssGGSKESLEF-------IRKALDDGEVVCIFPEGAITRNGQLNEFKR 533
|
570 580 590 600 610 620
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1524484190 553 GVTRILEETPVPVIPMALQGLWGSFFSRDpDKGLFHRIWSRV---VLVA-GAPVPvEEATPAQL-QAVV 616
Cdd:PRK08633 534 GFELIVKGTDVPIIPFYIRGLWGSIFSRA-SGKFLWRWPTRIpypVTVAfGKPMP-AHSTAHEVkQAVF 600
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
15-423 |
8.89e-48 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 172.03 E-value: 8.89e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524484190 15 FLPFFITQLLGAFNDNIFKQSLILAILYKltldGDRSIWVNLCALLFILPFFLFSALAGQFGEKFNKDALIRAIKLGEIV 94
Cdd:cd06173 1 FRLLWLAQLLSALGDWIFTVALPWLVLQL----TGSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRAL 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524484190 95 IMAVGATGFLFDHLEL--MLLALFAMGTHSALFGPVKYSIMPQALHDDELVGGNGLVEMGTFLAILAGTIGAGIMMSSTH 172
Cdd:cd06173 77 LAAVLALLALLGSLSLwlLLVLAFLLGIASAFFGPARQALLPELVPKEQLVRANALNSLATQLARIIGPALGGLLVALLG 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524484190 173 yAPVVAVAIVGVALLGYLASRSIPRAAASTPQLRLDWNIftQSWATLRMGLGQTPAVSRSIVGNSWFWFVGAIYLTQIPA 252
Cdd:cd06173 157 -PGGAFAINALSFLLSALLLLFIRRPPPAAPGESSSLLL--RDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPL 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524484190 253 YAKEWLYGDETVVTLILTVFSVGIALGSMLCEKLSGRKVEIGLVPFGSFGLTVFGLLLWWHSggfvqnvqpndwlavlgy 332
Cdd:cd06173 234 LAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSP------------------ 295
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524484190 333 gQAWWVLFDILGLGVFGGFYIVPLYALIQSRTAENQRARVIAANNILNALFMVVSAIVSILLLsvAKLSIPELFLVVSLL 412
Cdd:cd06173 296 -SLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGLLA--DALGLSAVFLLAGAL 372
|
410
....*....|.
gi 1524484190 413 NIAVNTYIFRI 423
Cdd:cd06173 373 LLLAALLLLLL 383
|
|
| PlsC |
COG0204 |
1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; ... |
418-624 |
1.61e-42 |
|
1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid transport and metabolism]; 1-acyl-sn-glycerol-3-phosphate acyltransferase is part of the Pathway/BioSystem: Phospholipid biosynthesis
Pssm-ID: 439974 [Multi-domain] Cd Length: 215 Bit Score: 152.47 E-value: 1.61e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524484190 418 TYIFRIVPEFTMRFMIWLLSHSM-YRVEHRNLEQIPDEGAALLVCNHVSFVDALLIGGAVRRPIRFVMYYKIYRLPVLNF 496
Cdd:COG0204 5 FLLLRRFRYRLVRLWARLLLRLLgVRVRVEGLENLPADGPVLIVANHQSWLDILLLLAALPRPVRFVAKKELFKIPLLGW 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524484190 497 IFRTAGAIPI--AGRHEDIqiyeKAFTRIAKYLKDGELVCIFPEGKLTGDGEMNEFRGGVTRILEETPVPVIPMALQGLW 574
Cdd:COG0204 85 LLRALGAIPVdrSKRRAAL----RALRQAVEALKAGESLVIFPEGTRSPDGRLLPFKTGAARLALEAGVPIVPVAIDGTE 160
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|
gi 1524484190 575 GSFFsrdpdKGLFHRIwSRVVLVAGAPVPVEEATPAQLQAVVGVLRGSVR 624
Cdd:COG0204 161 RALP-----KGFLPRP-GKVTVRIGPPIDPSDLEGEDRRELAERLRAAIE 204
|
|
| LPLAT_AGPAT-like |
cd07989 |
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; ... |
434-611 |
5.70e-42 |
|
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), Tafazzin (product of Barth syndrome gene), and similar proteins.
Pssm-ID: 153251 [Multi-domain] Cd Length: 184 Bit Score: 149.73 E-value: 5.70e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524484190 434 WLLSHSMYRVEHRNLEQIPDEGAALLVCNHVSFVDALLIGGAVRRPIRFVMYYKIYRLPVLNFIFRTAGAIPIAgRhEDI 513
Cdd:cd07989 3 LLLRLLGVRVRVEGLENLPPKGPVIIVANHQSYLDPLVLGAALPRPIRFVAKKELFKIPFLGWLLRLLGAIPID-R-GNG 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524484190 514 QIYEKAFTRIAKYLKDGELVCIFPEGKLTGDGEMNEFRGGVTRILEETPVPVIPMALQGLWGSFFsrdpdKGLFHRIWSR 593
Cdd:cd07989 81 RSAREALREAIEALKEGESVVIFPEGTRSRDGELLPFKSGAFRLAKEAGVPIVPVAISGTWGSLP-----KGKKLPRPGR 155
|
170
....*....|....*...
gi 1524484190 594 VVLVAGAPVPVEEATPAQ 611
Cdd:cd07989 156 VTVRIGEPIPPEGLELAE 173
|
|
| Acyltransferase |
pfam01553 |
Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis ... |
442-570 |
6.92e-24 |
|
Acyltransferase; This family contains acyltransferases involved in phospholipid biosynthesis and other proteins of unknown function. This family also includes tafazzin, the Barth syndrome gene.
Pssm-ID: 366704 [Multi-domain] Cd Length: 131 Bit Score: 97.35 E-value: 6.92e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524484190 442 RVEHRNLEQIPDEGAALLVCNHVSFVDALLIGGAV---RRPIRFVMYYKIYRLPVLNFIFRTAGAIPIagRHEDIQIYEK 518
Cdd:pfam01553 1 RIEVHGLENLPRGGPAIVVANHQSYLDVLLLSLALykrGRPLVFVAKKELFDIPLVGWLMRLLGCIFI--DRKNRKDAAG 78
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 1524484190 519 AFTRIAKYLKDGELVCIFPEGKLTGDGEMNEFRGGVTRILEETPVPVIPMAL 570
Cdd:pfam01553 79 TLEYLVELLREGKLVVIFPEGTRSREGELLPFKKGAFRLAIEAGVPIVPVAI 130
|
|
| PlsC |
smart00563 |
Phosphate acyltransferases; Function in phospholipid biosynthesis and have either ... |
457-573 |
1.15e-22 |
|
Phosphate acyltransferases; Function in phospholipid biosynthesis and have either glycerolphosphate, 1-acylglycerolphosphate, or 2-acylglycerolphosphoethanolamine acyltransferase activities. Tafazzin, the product of the gene mutated in patients with Barth syndrome, is a member of this family.
Pssm-ID: 214724 [Multi-domain] Cd Length: 118 Bit Score: 93.57 E-value: 1.15e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524484190 457 ALLVCNHVSFVDALLIGGAVRR---PIRFVMYYKIYRLPVLNFIFRTAGAIPIagRHEDIQIYEKAFTRIAKYLKDGELV 533
Cdd:smart00563 1 ALVVANHQSFLDPLVLSALLPRklgRVRFVAKKELFYVPLLGWLLRLLGAIFI--DRSNGRKARAALREAVELLKEGEWL 78
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 1524484190 534 CIFPEGKLTGDGEMNEFRGGVTRILEETPVPVIPMALQGL 573
Cdd:smart00563 79 LIFPEGTRSRPGKLLPFKKGAARLALEAGVPIVPVAIRGT 118
|
|
| LPLAT_AAK14816-like |
cd07992 |
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ... |
429-605 |
1.51e-20 |
|
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown AAK14816-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are uncharacterized glycerol-3-phosphate acyltransferases such as the Plasmodium falciparum locus AAK14816 putative acyltransferase, and similar proteins.
Pssm-ID: 153254 [Multi-domain] Cd Length: 203 Bit Score: 90.01 E-value: 1.51e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524484190 429 MRFMIWLLSHSMYR-VEHRNLEQIPDEGAALLVCNHV-SFVDALLIGGAVRRPIRFVMYYKIYRLPVLNFIFRTAGAIPI 506
Cdd:cd07992 1 VRLLSRVILRIYFRrITVVGRENVPKDGPVIFLGNHPnALIDPLLLAATLRRPVRFLAKADLFKNPLIGWLLESFGAIPV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524484190 507 -----AGRHEDIQI-YEKAFTRIAKYLKDGELVCIFPEGKLTGDGEMNEFRGGVTRILEE------TPVPVIPMALQglw 574
Cdd:cd07992 81 yrpkdLARGGIGKIsNAAVFDAVGEALKAGGAIGIFPEGGSHDRPRLLPLKAGAARMALEaleagqKDVKIVPVGLN--- 157
|
170 180 190
....*....|....*....|....*....|.
gi 1524484190 575 gsFFSRdpdkglfHRIWSRVVLVAGAPVPVE 605
Cdd:cd07992 158 --YEDK-------SRFRSRVLVEFGKPISVS 179
|
|
| AGP_acyltrn |
TIGR00530 |
1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous ... |
443-571 |
7.33e-18 |
|
1-acyl-sn-glycerol-3-phosphate acyltransferases; This model describes the core homologous region of a collection of related proteins, several of which are known to act as 1-acyl-sn-glycerol-3-phosphate acyltransferases (EC 2.3.1.51). Proteins scoring above the trusted cutoff are likely to have the same general activity. However, there is variation among characterized members as to whether the acyl group can be donated by acyl carrier protein or coenzyme A, and in the length and saturation of the donated acyl group. 1-acyl-sn-glycerol-3-phosphate acyltransferase is also called 1-AGP acyltransferase, lysophosphatidic acid acyltransferase, and LPA acyltransferase. [Fatty acid and phospholipid metabolism, Biosynthesis]
Pssm-ID: 129621 [Multi-domain] Cd Length: 130 Bit Score: 80.08 E-value: 7.33e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524484190 443 VEHRNLEQIPDEGAALLVCNHVSFVDALLIGGAVRRPIRFVMYYKIYRLPVLNFIFRTAGAIPIagRHEDIQIYEKAFTR 522
Cdd:TIGR00530 4 VEVVGPENLPAKSPVLVVANHQSNLDPLTLSAAFPPPIVFIAKKELKWIPFFGIMLWLTGAIFI--DRENIRAIATALKA 81
|
90 100 110 120
....*....|....*....|....*....|....*....|....*....
gi 1524484190 523 IAKYLKDGELVCIFPEGKLTGDGEMNEFRGGVTRILEETPVPVIPMALQ 571
Cdd:TIGR00530 82 AIEVLKQGRSIGVFPEGTRSRGRDILPFKKGAFHIAIKAGVPILPVVLS 130
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
93-387 |
2.61e-11 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 65.38 E-value: 2.61e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524484190 93 IVIMAVGATGFLF-DHLELMLLALFAMGTHSALFGPVKYSIMPQALHDDELVGGNGLVEMGTFLAILAGTIGAGIMMSST 171
Cdd:COG2814 82 LLLFALGSLLCALaPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADLF 161
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524484190 172 HYAPVVAVAIVGVALLGYLASRSIPRAAASTPqlrldwnifTQSWATLRMGLGqTPAVSRSIVGNSWFWFVGAIYLTQIP 251
Cdd:COG2814 162 GWRWVFLVNAVLALLALLLLLRLLPESRPAAR---------ARLRGSLRELLR-RPRLLLLLLLAFLLGFGFFALFTYLP 231
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524484190 252 AYAKEWLYGDETVVTLILTVFSVGIALGSMLCEKLSGRkVEIGLVPFGSFGLTVFGLLLWWHSGGFvqnvqpndwlavlg 331
Cdd:COG2814 232 LYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADR-FGRRRLLLIGLLLLALGLLLLALAGSL-------------- 296
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*.
gi 1524484190 332 ygqaWWVLFDILGLGVFGGFYIVPLYALIQSRTAENQRARVIAANNILNALFMVVS 387
Cdd:COG2814 297 ----WLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPLA 348
|
|
| PLN02901 |
PLN02901 |
1-acyl-sn-glycerol-3-phosphate acyltransferase |
441-572 |
3.13e-11 |
|
1-acyl-sn-glycerol-3-phosphate acyltransferase
Pssm-ID: 215488 [Multi-domain] Cd Length: 214 Bit Score: 63.21 E-value: 3.13e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524484190 441 YRVEHRNLEQIP-DEGAALLVCNHVSFVD--ALLiggAVRRPIRFVMYYKIYRLPVLNFIFRTAGAIPIagRHEDIQIYE 517
Cdd:PLN02901 35 YKIEVEGLENLPsPDEPAVYVSNHQSFLDiyTLF---HLGRPFKFISKTSIFLIPIIGWAMYMTGHIPL--KRMDRRSQL 109
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 1524484190 518 KAFTRIAKYLKDGELVCIFPEGKLTGDGEMNEFRGGVTRILEETPVPVIPMALQG 572
Cdd:PLN02901 110 ECLKRCMELLKKGASVFFFPEGTRSKDGKLAAFKKGAFSVAAKTGVPVVPITLVG 164
|
|
| PRK11195 |
PRK11195 |
lysophospholipid transporter LplT; Provisional |
70-363 |
9.64e-11 |
|
lysophospholipid transporter LplT; Provisional
Pssm-ID: 236879 [Multi-domain] Cd Length: 393 Bit Score: 64.09 E-value: 9.64e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524484190 70 ALAGQFGEKFNKD---ALIRAIKLGEIVIMAVGAtgflfdHLelmLLALFAMGTHSALFGPVKYSIMPQALHDDELVGGN 146
Cdd:PRK11195 56 PFVGAFADSFPKGrvmFIANGIKLLGCLLMLFGI------HP---LLAYGLVGIGAAAYSPAKYGILTELLPGEKLVKAN 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524484190 147 GLVEMGTFLAILAGTIGAGIMMSstHYAPVVAVAIVGVALLGYLASRSIPRAAASTPQLRldWNI------FTQSWATL- 219
Cdd:PRK11195 127 GWMEGSTIAAILLGTVLGGALAD--PHAEAALAVCALIYLLAALFNLFIPRLGARRPGQS--WNPiallrdFFHACRVLw 202
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524484190 220 RMGLGQTpavsrSIVGNSWFWFVGAIYLTQIPAYAKEWLYGDETVVTLILTVFSVGIALGSMLCEKLSGRKVEIGLVPFG 299
Cdd:PRK11195 203 RDKLGRF-----SLAGTTLFWGAGATLRFLVLAWAPVALGITLNQPAYLQAVVAIGIAVGAGAAARLVTLETVLRVLPAG 277
|
250 260 270 280 290 300
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1524484190 300 -SFGLTVFGLllwwhsggfvqNVQPNDWLAVLGygqawwvlfdILGLGVFGGFYIVPLYALIQSR 363
Cdd:PRK11195 278 iLMGLVVLLM-----------ALQHSLLPAYPL----------LILIGALGGFFVVPMNALLQHR 321
|
|
| LPLAT |
cd06551 |
Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; ... |
429-606 |
3.30e-10 |
|
Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Lysophospholipid acyltransferase (LPLAT) superfamily members are acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis. These proteins catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this superfamily are LPLATs such as glycerol-3-phosphate 1-acyltransferase (GPAT, PlsB), 1-acyl-sn-glycerol-3-phosphate acyltransferase (AGPAT, PlsC), lysophosphatidylcholine acyltransferase 1 (LPCAT-1), lysophosphatidylethanolamine acyltransferase (LPEAT, also known as, MBOAT2, membrane-bound O-acyltransferase domain-containing protein 2), lipid A biosynthesis lauroyl/myristoyl acyltransferase, 2-acylglycerol O-acyltransferase (MGAT), dihydroxyacetone phosphate acyltransferase (DHAPAT, also known as 1 glycerol-3-phosphate O-acyltransferase 1) and Tafazzin (the protein product of the Barth syndrome (TAZ) gene).
Pssm-ID: 153244 [Multi-domain] Cd Length: 187 Bit Score: 59.74 E-value: 3.30e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524484190 429 MRFMIWLLSHsMYRVEHRNLEQIPDEGAALLVCNHVSFVDAL----LIGGAVRRPIRFVM-YYKIYRLPVlnfiFRTAGA 503
Cdd:cd06551 1 FRYLLLNFFG-FVRLEVKGPPPPPGGGPVLFVSNHSSWWDGLilflLLERGLRRDVYGLMdEELLERYPF----FTRLGA 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524484190 504 IPIA--GRHEDIQIYEKAFTRIAKYlkdGELVCIFPEGKlTGDGEMN--EFRGGVTRILEETPVPVIPMALQglwGSFFS 579
Cdd:cd06551 76 FSVDrdSPRSAAKSLKYVARLLSKP---GSVVWIFPEGT-RTRRDKRplQFKPGVAHLAEKAGVPIVPVALR---YTFEL 148
|
170 180
....*....|....*....|....*..
gi 1524484190 580 RDPDKGLFHRIwsrvvlvaGAPVPVEE 606
Cdd:cd06551 149 FEQFPEIFVRI--------GPPIPYAE 167
|
|
| LPLAT_MGAT-like |
cd07987 |
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; ... |
444-572 |
4.21e-10 |
|
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: MGAT-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this suubgroup are such LPLATs as 2-acylglycerol O-acyltransferase (MGAT), and similar proteins.
Pssm-ID: 153249 [Multi-domain] Cd Length: 212 Bit Score: 59.99 E-value: 4.21e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524484190 444 EHRNLEQIPDEGAALLVCNH-VSFVDALLIGGAVR-----RPIRFVMYYKIYRLPVLNFIFRTAGAIPIAGRHediqiye 517
Cdd:cd07987 9 EVRGLENIPDEGPALLVHPHgGLPIDGALLAAAFLllfpgRLPRALADHFLFPLPGLRDLLRRLGAVPGSREN------- 81
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1524484190 518 kaftrIAKYLKDGELVCIFPEG----KLTGDGEMN---EFRGGVTRILEETPVPVIPMALQG 572
Cdd:cd07987 82 -----CVRLLREGELVLIFPGGareaLKSKREEYYllwKKRKGFARLALRAGAPIVPVFTFG 138
|
|
| LPLAT_LPCAT1-like |
cd07991 |
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like; ... |
429-571 |
3.62e-08 |
|
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LPCAT1-like; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are such LPLATs as lysophosphatidylcholine acyltransferase 1 (LPCAT-1), glycerol-3-phosphate acyltransferase 3 (GPAT3), and similar sequences.
Pssm-ID: 153253 [Multi-domain] Cd Length: 211 Bit Score: 54.15 E-value: 3.62e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524484190 429 MRFMIWLLSHsmYRVEHRNlEQIPDEGAALLVCNHVSFVDALLIggAVRRPIRFVMYYKIYRLPVLNFIFRTAGAIPIaG 508
Cdd:cd07991 1 ARVLLFAFGF--YVIKVHG-KPDPPEAPRIIVANHTSFIDPLIL--FSDLFPSIVAKKELGKLPFIGTILRALGCIFV-D 74
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1524484190 509 RhEDIQIYEKAFTRIAKYLKDGEL--VCIFPEGKLT-GDGEMnEFRGGVTrileETPVPVIPMALQ 571
Cdd:cd07991 75 R-SEPKDRKKVVEEIKERATDPNWppILIFPEGTTTnGKALI-MFKKGAF----EPGVPVQPVAIR 134
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
86-424 |
7.17e-08 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 54.89 E-value: 7.17e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524484190 86 RAIKLGEIVIMAVGATGFLFDHLELMLLALFAMGTHSALFGPVKYSIMPQALHDDELVGGNGLVEMGTFLAILAGTIGAG 165
Cdd:cd17325 62 RLLLLGLLLLAVSTLLFAFATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLLGG 141
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524484190 166 IMMSSTHYAPVVAVAIVGVALLGYLASRSIPRAAASTPQLRLDWNIFTQSWATLRMGlgqtPAVSRSIVGNSWFWFVGAI 245
Cdd:cd17325 142 LLADALGYRAPFLVCAALALLALVLALLLLPEPRPPPNKRAVSAARLRSGLRLLLRD----RRLLALFLAIFVLAFAFGA 217
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524484190 246 YLTQIPAYAKEWLYGDETVVTLILTVFSVGIALGSMLCEKLSGRKVEIGLVPFGSFgLTVFGLLLWWHSGGFvqnvqpnd 325
Cdd:cd17325 218 LEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLL-LSAVALLLLPLATSF-------- 288
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524484190 326 wlavlgygqaWWVLFDILGLGVFGGFYIVPLYALIQSRTAENQRARVIAANNILNALFMVVSAIVSILLlsVAKLSIPEL 405
Cdd:cd17325 289 ----------WLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFL--YDAFGFATP 356
|
330
....*....|....*....
gi 1524484190 406 FLVVSLLNIAVNTYIFRIV 424
Cdd:cd17325 357 FLAAAALLLLAAVLFLLLR 375
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
86-414 |
4.12e-06 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 49.35 E-value: 4.12e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524484190 86 RAIKLGEIVIMAVGATGFLFDHLELMLLALFAMGTHSALFGPVKYSIMPQALHDDELVGGNGLVEMGTFLAILAGTIGAG 165
Cdd:cd06174 62 PVLLLGLLLFALGALLFAFAPSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGG 141
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524484190 166 IMMSSTHYAPVVAVAIVGVALLGYLASRSIPRAAASTPQLRLDWNIFTQSWATLRMGLGQTPAVSRSIVGNSWFWFVGAI 245
Cdd:cd06174 142 ILASSLGFGWRAVFLIAAALALLAAILLLLVVPDPPESARAKNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYS 221
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524484190 246 YLTQIPAYAKEWLYGDETVVTLILTVFSVGIALGSMLCEKLSGRKVEIGLVPFGSFGLTVFGLLLWWHSggfvqnvqpnd 325
Cdd:cd06174 222 FSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLIGRKPLLLIGLLLMALGLALLLLA----------- 290
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524484190 326 wlavlgyGQAWWVLFDILGLGVFGGFYIVPLYALIQSRTAENQRARVIAANNILNALFMVVSAIVSILLLsVAKLSIPEL 405
Cdd:cd06174 291 -------PSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLL-AATFGLTGA 362
|
....*....
gi 1524484190 406 FLVVSLLNI 414
Cdd:cd06174 363 FLVLAVLLL 371
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
93-388 |
6.70e-06 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 48.57 E-value: 6.70e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524484190 93 IVIMAVGATGFLFDH-LELMLLALFAMGTHSALFGPVKYSIMPQALHDDELVGGNGLVEMGTFLAILAGTIGAGIMMSST 171
Cdd:pfam07690 69 LLLFALGLLLLLFASsLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLF 148
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524484190 172 HYAPVVAVAIVGVALLGYLASRSIPRAAASTP-QLRLDWNIFTQSWATLRmglgqTPAVSRSIVGNSWFWFVGAIYLTQI 250
Cdd:pfam07690 149 GWRAAFLILAILSLLAAVLLLLPRPPPESKRPkPAEEARLSLIVAWKALL-----RDPVLWLLLALLLFGFAFFGLLTYL 223
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524484190 251 PAYAKEwLYGDETVVTLILTVFSVGIALGSMLCEKLSGRKVEIGLVPFGSFGLTVFGLLLWWhsggfvqnvqpndwlaVL 330
Cdd:pfam07690 224 PLYQEV-LGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLL----------------LS 286
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 1524484190 331 GYGQAWWVLFDILGLGVFGGFYIVPLYALIQSRTAENQRARVIAANNILNALFMVVSA 388
Cdd:pfam07690 287 LTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
|
|
| LPLAT_ACT14924-like |
cd07986 |
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ... |
441-572 |
8.35e-06 |
|
Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ACT14924; Lysophospholipid acyltransferase (LPLAT) superfamily member: acyltransferases of de novo and remodeling pathways of glycerophospholipid biosynthesis which catalyze the incorporation of an acyl group from either acylCoAs or acyl-acyl carrier proteins (acylACPs) into acceptors such as glycerol 3-phosphate, dihydroxyacetone phosphate or lyso-phosphatidic acid. Included in this subgroup are uncharacterized phospholipid/glycerol acyltransferases such as the Pectobacterium carotovorum subsp. carotovorum PC1 locus ACT14924 putative acyltransferase, and similar proteins.
Pssm-ID: 153248 [Multi-domain] Cd Length: 210 Bit Score: 47.24 E-value: 8.35e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524484190 441 YRVEHRNLEQIPDEGAALLVCNH-VSFVDALLIG---GAVRRPIRFVMYYKIYRLPVLNFIFrtagaIPIAGRHEDIQIY 516
Cdd:cd07986 8 LEVDVSGLENIPKDGPVVIVANHpFGILDGLILAdllGSVRPDVRILANQLLSKIPELRDLF-----IPVDPLEGRAALA 82
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1524484190 517 EKAFTR--IAKYLKDGELVCIFPEGKLTgdgEMNEFRGGVT---------RILEETPVPVIPMALQG 572
Cdd:cd07986 83 KNRESLreALRHLKNGGALIIFPAGRVS---TASPPFGRVSdrpwnpfvaRLARKAKAPVVPVYFSG 146
|
|
| PRK08043 |
PRK08043 |
bifunctional acyl-ACP--phospholipid O-acyltransferase/long-chain-fatty-acid--ACP ligase; |
430-591 |
8.44e-06 |
|
bifunctional acyl-ACP--phospholipid O-acyltransferase/long-chain-fatty-acid--ACP ligase;
Pssm-ID: 181207 [Multi-domain] Cd Length: 718 Bit Score: 48.94 E-value: 8.44e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524484190 430 RFMIWLLSHsMYRVEHRNLEQIPDEGAALLVCNHVSFVDALLIggAVRRPIR--FVMYYKIYRLPVLNFIFRTAGAIPIA 507
Cdd:PRK08043 4 SFFRNLFRV-LYRVRVTGDTQALKGERVLITPNHVSFLDGILL--ALFLPVRpvFAVYTSISQQWYMRWLKPYIDFVPLD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524484190 508 GRHediqiyEKAFTRIAKYLKDGELVCIFPEGKLTGDGEMNEFRGGVTRILEETPVPVIPMALQGLWGSFFSRdpDKGLF 587
Cdd:PRK08043 81 PTK------PMAIKHLVRLVEQGRPVVIFPEGRITVTGSLMKIYDGAGFVAAKSGATVIPVRIEGAELTHFSR--LKGLV 152
|
....
gi 1524484190 588 HRIW 591
Cdd:PRK08043 153 KRRL 156
|
|
| COG3176 |
COG3176 |
Putative hemolysin [General function prediction only]; |
441-578 |
1.17e-05 |
|
Putative hemolysin [General function prediction only];
Pssm-ID: 442409 Cd Length: 270 Bit Score: 47.34 E-value: 1.17e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524484190 441 YRVEHRNLEQIPDEGAALLVCNH-VSFVDALLIG---GAVRRPIRFVMYYKIYRLPvlnFIFRTAGAIPIAGRHediqiy 516
Cdd:COG3176 57 LEVPEGDLDRIDADGHLLVVANHpLGILDGLALLklvGTVRPDYRILANDLALRIP---GGFYSELEFPVDPFN------ 127
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1524484190 517 EKAFTRIAKYLKDGELVCIFPEGKLTGDGEMNE--FRGGVTRILEETPVPVIPMALQGLWGSFF 578
Cdd:COG3176 128 LETLKAARRHLLEGGRSCVFPAGRVSGARRVIDllWSGLAAKLARKAGAPVVPVYFDGRNSGLF 191
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
248-416 |
3.08e-04 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 43.33 E-value: 3.08e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524484190 248 TQIPAYAKEWLYGDETVVTLILTVFSVGIALGSMLCEKLSGRKVEIGLVPFGsFGLTVFGLLLWWHSGGFvqnvqpndwl 327
Cdd:cd17473 218 IQLPFLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLGKRRLLAIG-FALMALGFLLLALASGL---------- 286
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524484190 328 avlgygqaWWVLFDILGLGVFGGFYIVPLYALIQSRTAENQRARVIAANNILNALFMVVSAIVSILLLSVAkLSIPELFL 407
Cdd:cd17473 287 --------WVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGIVTSAFFLGQFLSPLVLGPLVNLT-GGLSGAFL 357
|
....*....
gi 1524484190 408 VVSLLNIAV 416
Cdd:cd17473 358 ILGVLALVL 366
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
239-398 |
4.23e-04 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 42.97 E-value: 4.23e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524484190 239 FWFVGAIYLTQIPAYAKEWLYGDETVVTLILTVFSVGIALGSMLCEKLSGRkveiglvpFGSFGLTVFGLLLWwhSGGFV 318
Cdd:COG2211 240 FFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKR--------FGKKKAFIIGLLLA--ALGLL 309
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524484190 319 qnvqpndWLAVLGYGQAWWVLFDILGLGVFGGFYIVPLYALI-------QSRTAENQRARVIAANNILNALFMVVSAIVS 391
Cdd:COG2211 310 -------LLFFLGPGNLWLLLVLAALAGIGLGAILVLPWAMLadvvdydEWKTGRRREGLYFGIFTFAIKLGQALAGALA 382
|
....*..
gi 1524484190 392 ILLLSVA 398
Cdd:COG2211 383 GLLLALF 389
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
233-426 |
4.29e-04 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 43.04 E-value: 4.29e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524484190 233 IVGNSWFWFVGAIYLTQIPAYAKEwLYGDETVVTLILTVFSVGIALGSMLCEKLSGRKVEIGLVPFGSFGLTVFGLLLww 312
Cdd:COG2814 16 ALGAFLSGLGIGIVLPALPLIAAD-LGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLC-- 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524484190 313 hsgGFVQNVqpndwlavlgygqaWWVLFDILGLGVFGGFYIVPLYALIQSRTAENQRARVIAANNILNALFMVVSAIVSI 392
Cdd:COG2814 93 ---ALAPSL--------------WLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGG 155
|
170 180 190
....*....|....*....|....*....|....
gi 1524484190 393 LLLSVakLSIPELFLVVSLLNIAVNTYIFRIVPE 426
Cdd:COG2814 156 LLADL--FGWRWVFLVNAVLALLALLLLLRLLPE 187
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
239-426 |
4.11e-03 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 39.71 E-value: 4.11e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524484190 239 FWFVGAIYLTQIPAYAKEWLYGDETVVTLILTVFSVGIALGSMLCEKLSGRkveIGLVPFGSFGLTVFGLLLWWhsGGFV 318
Cdd:pfam07690 8 AALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDR---FGRRRVLLIGLLLFALGLLL--LLFA 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1524484190 319 QNVqpndwlavlgygqaWWVLFDILGLGVFGGFYIVPLYALIQSRTAENQRARVIAANNILNALFMVVSAIVSILLLSVa 398
Cdd:pfam07690 83 SSL--------------WLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASL- 147
|
170 180
....*....|....*....|....*...
gi 1524484190 399 kLSIPELFLVVSLLNIAVNTYIFRIVPE 426
Cdd:pfam07690 148 -FGWRAAFLILAILSLLAAVLLLLPRPP 174
|
|
| |
