Cytochrome c-type biogenesis protein CcmC, putative heme lyase for CcmE [Pseudomonas sp. R11-23-07]
Protein Classification
heme ABC transporter permease( domain architecture ID 10018730)
heme ABC transporter permease such as Escherichia coli heme exporter protein C (CcmC), which is required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
List of domain hits
| Name | Accession | Description | Interval | E-value | ||||
| ccmC | TIGR01191 | heme exporter protein CcmC; This model describes the cyt c biogenesis protein encoded by ccmC ... |
46-229 | 2.65e-92 | ||||
heme exporter protein CcmC; This model describes the cyt c biogenesis protein encoded by ccmC in bacteria. It must be noted an arabidopsis, a tritcum and a piscum plant proteins were recognizable in the clade. Quite likely they are of organellar origin. Bacterial c-type cytocromes are located on the periplasmic side of the cytoplasmic membrane. Several gene products encoded in a locus designated as 'ccm' are implicated in the transport and assembly of the functional cytochrome C. This cluster includes genes, ccmA;B;C;D;E;F;G and H. The posttranslational pathway includes the transport of heme moiety, the secretion of the apoprotein and the covalent attachment of the heme with the apoprotein. The proteins ccmA and B represent an ABC transporter; ccmC and D participate in the heme transfer to ccmE, which function as a periplasmic heme chaperone. The presence of ccmF, G and H is suggested to be obligatory for the final functional assembly of cytochrome c. [Protein fate, Protein and peptide secretion and trafficking, Transport and binding proteins, Other] : Pssm-ID: 273492 Cd Length: 184 Bit Score: 269.62 E-value: 2.65e-92
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| IgaA super family | cl06224 | Intracellular growth attenuator protein IgaA; This family consists of several bacterial ... |
4-47 | 4.93e-03 | ||||
Intracellular growth attenuator protein IgaA; This family consists of several bacterial intracellular growth attenuator (IgaA) proteins. IgaA is involved in negative control of bacterial proliferation within fibroblasts. IgaA is homologous to the E. coli YrfF and P. mirabilis UmoB proteins. Whereas the biological function of YrfF is currently unknown, UmoB has been shown elsewhere to act as a positive regulator of FlhDC, the master regulator of flagella and swarming. FlhDC has been shown to repress cell division during P. mirabilis swarming, suggesting that UmoB could repress cell division via FlhDC. This biological function, if maintained in S. enterica, could sustain a putative negative control of cell division and growth exerted by IgaA in intracellular bacteria. The actual alignment was detected with superfamily member pfam07095: Pssm-ID: 429290 Cd Length: 696 Bit Score: 38.09 E-value: 4.93e-03
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| Name | Accession | Description | Interval | E-value | ||||
| ccmC | TIGR01191 | heme exporter protein CcmC; This model describes the cyt c biogenesis protein encoded by ccmC ... |
46-229 | 2.65e-92 | ||||
heme exporter protein CcmC; This model describes the cyt c biogenesis protein encoded by ccmC in bacteria. It must be noted an arabidopsis, a tritcum and a piscum plant proteins were recognizable in the clade. Quite likely they are of organellar origin. Bacterial c-type cytocromes are located on the periplasmic side of the cytoplasmic membrane. Several gene products encoded in a locus designated as 'ccm' are implicated in the transport and assembly of the functional cytochrome C. This cluster includes genes, ccmA;B;C;D;E;F;G and H. The posttranslational pathway includes the transport of heme moiety, the secretion of the apoprotein and the covalent attachment of the heme with the apoprotein. The proteins ccmA and B represent an ABC transporter; ccmC and D participate in the heme transfer to ccmE, which function as a periplasmic heme chaperone. The presence of ccmF, G and H is suggested to be obligatory for the final functional assembly of cytochrome c. [Protein fate, Protein and peptide secretion and trafficking, Transport and binding proteins, Other] Pssm-ID: 273492 Cd Length: 184 Bit Score: 269.62 E-value: 2.65e-92
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| CcmC | COG0755 | ABC-type transport system involved in cytochrome c biogenesis, permease component ... |
28-185 | 3.03e-40 | ||||
ABC-type transport system involved in cytochrome c biogenesis, permease component [Posttranslational modification, protein turnover, chaperones]; Pssm-ID: 440518 [Multi-domain] Cd Length: 213 Bit Score: 137.72 E-value: 3.03e-40
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| Cytochrom_C_asm | pfam01578 | Cytochrome C assembly protein; This family consists of various proteins involved in cytochrome ... |
5-185 | 1.70e-27 | ||||
Cytochrome C assembly protein; This family consists of various proteins involved in cytochrome c assembly from mitochondria and bacteria; CycK from Rhizobium, CcmC from E. coli and Paracoccus denitrificans.and orf240 from wheat mitochondria. The members of this family are probably integral membrane proteins with six predicted transmembrane helices. It has been proposed that members of this family comprise a membrane component of an ABC (ATP binding cassette) transporter complex. It is also proposed that this transporter is necessary for transport of some component needed for cytochrome c assembly. One member CycK contains a putative heme-binding motif, orf240 also contains a putative heme-binding motif and is a proposed ABC transporter with c-type heme as its proposed substrate. However it seems unlikely that all members of this family transport heme nor c-type apocytochromes because CcmC in the putative CcmABC transporter transports neither. CcmF forms a working module with CcmH and CcmI, CcmFHI, and itself is unlikely to bind haem directly. Pssm-ID: 307628 [Multi-domain] Cd Length: 211 Bit Score: 104.75 E-value: 1.70e-27
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| IgaA | pfam07095 | Intracellular growth attenuator protein IgaA; This family consists of several bacterial ... |
4-47 | 4.93e-03 | ||||
Intracellular growth attenuator protein IgaA; This family consists of several bacterial intracellular growth attenuator (IgaA) proteins. IgaA is involved in negative control of bacterial proliferation within fibroblasts. IgaA is homologous to the E. coli YrfF and P. mirabilis UmoB proteins. Whereas the biological function of YrfF is currently unknown, UmoB has been shown elsewhere to act as a positive regulator of FlhDC, the master regulator of flagella and swarming. FlhDC has been shown to repress cell division during P. mirabilis swarming, suggesting that UmoB could repress cell division via FlhDC. This biological function, if maintained in S. enterica, could sustain a putative negative control of cell division and growth exerted by IgaA in intracellular bacteria. Pssm-ID: 429290 Cd Length: 696 Bit Score: 38.09 E-value: 4.93e-03
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| Name | Accession | Description | Interval | E-value | ||||
| ccmC | TIGR01191 | heme exporter protein CcmC; This model describes the cyt c biogenesis protein encoded by ccmC ... |
46-229 | 2.65e-92 | ||||
heme exporter protein CcmC; This model describes the cyt c biogenesis protein encoded by ccmC in bacteria. It must be noted an arabidopsis, a tritcum and a piscum plant proteins were recognizable in the clade. Quite likely they are of organellar origin. Bacterial c-type cytocromes are located on the periplasmic side of the cytoplasmic membrane. Several gene products encoded in a locus designated as 'ccm' are implicated in the transport and assembly of the functional cytochrome C. This cluster includes genes, ccmA;B;C;D;E;F;G and H. The posttranslational pathway includes the transport of heme moiety, the secretion of the apoprotein and the covalent attachment of the heme with the apoprotein. The proteins ccmA and B represent an ABC transporter; ccmC and D participate in the heme transfer to ccmE, which function as a periplasmic heme chaperone. The presence of ccmF, G and H is suggested to be obligatory for the final functional assembly of cytochrome c. [Protein fate, Protein and peptide secretion and trafficking, Transport and binding proteins, Other] Pssm-ID: 273492 Cd Length: 184 Bit Score: 269.62 E-value: 2.65e-92
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| CcmC | COG0755 | ABC-type transport system involved in cytochrome c biogenesis, permease component ... |
28-185 | 3.03e-40 | ||||
ABC-type transport system involved in cytochrome c biogenesis, permease component [Posttranslational modification, protein turnover, chaperones]; Pssm-ID: 440518 [Multi-domain] Cd Length: 213 Bit Score: 137.72 E-value: 3.03e-40
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| Cytochrom_C_asm | pfam01578 | Cytochrome C assembly protein; This family consists of various proteins involved in cytochrome ... |
5-185 | 1.70e-27 | ||||
Cytochrome C assembly protein; This family consists of various proteins involved in cytochrome c assembly from mitochondria and bacteria; CycK from Rhizobium, CcmC from E. coli and Paracoccus denitrificans.and orf240 from wheat mitochondria. The members of this family are probably integral membrane proteins with six predicted transmembrane helices. It has been proposed that members of this family comprise a membrane component of an ABC (ATP binding cassette) transporter complex. It is also proposed that this transporter is necessary for transport of some component needed for cytochrome c assembly. One member CycK contains a putative heme-binding motif, orf240 also contains a putative heme-binding motif and is a proposed ABC transporter with c-type heme as its proposed substrate. However it seems unlikely that all members of this family transport heme nor c-type apocytochromes because CcmC in the putative CcmABC transporter transports neither. CcmF forms a working module with CcmH and CcmI, CcmFHI, and itself is unlikely to bind haem directly. Pssm-ID: 307628 [Multi-domain] Cd Length: 211 Bit Score: 104.75 E-value: 1.70e-27
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| IgaA | pfam07095 | Intracellular growth attenuator protein IgaA; This family consists of several bacterial ... |
4-47 | 4.93e-03 | ||||
Intracellular growth attenuator protein IgaA; This family consists of several bacterial intracellular growth attenuator (IgaA) proteins. IgaA is involved in negative control of bacterial proliferation within fibroblasts. IgaA is homologous to the E. coli YrfF and P. mirabilis UmoB proteins. Whereas the biological function of YrfF is currently unknown, UmoB has been shown elsewhere to act as a positive regulator of FlhDC, the master regulator of flagella and swarming. FlhDC has been shown to repress cell division during P. mirabilis swarming, suggesting that UmoB could repress cell division via FlhDC. This biological function, if maintained in S. enterica, could sustain a putative negative control of cell division and growth exerted by IgaA in intracellular bacteria. Pssm-ID: 429290 Cd Length: 696 Bit Score: 38.09 E-value: 4.93e-03
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| Blast search parameters | ||||
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