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Conserved domains on  [gi|1551608680|gb|AZW74721|]
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flagellar protein FliT [Bordetella pertussis]

Protein Classification

flagellar protein FliT( domain architecture ID 10526792)

flagellar biosynthesis protein FliT acts as a substrate-specific chaperone that protects its substrate (FliD) from degradation and aggregation in the cytoplasm and efficiently transfers the substrate to the export apparatus

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FliT pfam05400
Flagellar protein FliT; This family contains several bacterial flagellar FliT proteins. The ...
 34-119 1.87e-21

Flagellar protein FliT; This family contains several bacterial flagellar FliT proteins. The flagellar proteins FlgN and FliT have been proposed to act as substrate specific export chaperones, facilitating incorporation of the enterobacterial hook-associated axial proteins (HAPs) FlgK/FlgL and FliD into the growing flagellum. In Salmonella typhimurium flgN and fliT mutants, the export of target HAPs is reduced, concomitant with loss of unincorporated flagellin into the surrounding medium.


:

Pssm-ID: 461640  Cd Length: 86  Bit Score: 81.61  E-value: 1.87e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1551608680  34 MLAAANASNWDLVLNHGQEYVCLVERLRELEPGEPLDEAARGMKFDLLVRILENDAAVRDLALPQLARLSDLLGRMKRQQ 113
Cdd:pfam05400   1 MLEAARAGDWDELVALEAERQQLVERLRELEPEAPLSDAERAEKRELLRRILENDAEIRALLQPRLDELQKLLGQARRQR 80


                  ....*.
gi 1551608680 114 SLLATY 119
Cdd:pfam05400  81 KANNAY 86
 
Name Accession Description Interval E-value
FliT pfam05400
Flagellar protein FliT; This family contains several bacterial flagellar FliT proteins. The ...
 34-119 1.87e-21

Flagellar protein FliT; This family contains several bacterial flagellar FliT proteins. The flagellar proteins FlgN and FliT have been proposed to act as substrate specific export chaperones, facilitating incorporation of the enterobacterial hook-associated axial proteins (HAPs) FlgK/FlgL and FliD into the growing flagellum. In Salmonella typhimurium flgN and fliT mutants, the export of target HAPs is reduced, concomitant with loss of unincorporated flagellin into the surrounding medium.


Pssm-ID: 461640  Cd Length: 86  Bit Score: 81.61  E-value: 1.87e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1551608680  34 MLAAANASNWDLVLNHGQEYVCLVERLRELEPGEPLDEAARGMKFDLLVRILENDAAVRDLALPQLARLSDLLGRMKRQQ 113
Cdd:pfam05400   1 MLEAARAGDWDELVALEAERQQLVERLRELEPEAPLSDAERAEKRELLRRILENDAEIRALLQPRLDELQKLLGQARRQR 80


                  ....*.
gi 1551608680 114 SLLATY 119
Cdd:pfam05400  81 KANNAY 86
PRK10548 PRK10548
flagella biosynthesis regulatory protein FliT;
14-120 5.35e-11

flagella biosynthesis regulatory protein FliT;


Pssm-ID: 182538  Cd Length: 121  Bit Score: 55.38  E-value: 5.35e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1551608680  14 LTQHAPVLEIYQDIANLTSRMLAAANASNWDLVLNHGQEYVCLVERLRELEPGEPLDEAARGMKFDLLVRILENDAAVRD 93
Cdd:PRK10548    1 MNNAPHLLSAWQQILTLSQSMLRLATEGQWDELIEQEVAYVQAVEEIAHLTIPPDISTVMQEQLRPMLRQILDNEAELKQ 80

                          90       100
                  ....*....|....*....|....*..
gi 1551608680  94 LALPQLARLSDLLGRMKRQQSLLATYS 120
Cdd:PRK10548   81 LLQQRMDELSSLIGQSTRQKSVNSAYG 107
 
Name Accession Description Interval E-value
FliT pfam05400
Flagellar protein FliT; This family contains several bacterial flagellar FliT proteins. The ...
 34-119 1.87e-21

Flagellar protein FliT; This family contains several bacterial flagellar FliT proteins. The flagellar proteins FlgN and FliT have been proposed to act as substrate specific export chaperones, facilitating incorporation of the enterobacterial hook-associated axial proteins (HAPs) FlgK/FlgL and FliD into the growing flagellum. In Salmonella typhimurium flgN and fliT mutants, the export of target HAPs is reduced, concomitant with loss of unincorporated flagellin into the surrounding medium.


Pssm-ID: 461640  Cd Length: 86  Bit Score: 81.61  E-value: 1.87e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1551608680  34 MLAAANASNWDLVLNHGQEYVCLVERLRELEPGEPLDEAARGMKFDLLVRILENDAAVRDLALPQLARLSDLLGRMKRQQ 113
Cdd:pfam05400   1 MLEAARAGDWDELVALEAERQQLVERLRELEPEAPLSDAERAEKRELLRRILENDAEIRALLQPRLDELQKLLGQARRQR 80


                  ....*.
gi 1551608680 114 SLLATY 119
Cdd:pfam05400  81 KANNAY 86
PRK10548 PRK10548
flagella biosynthesis regulatory protein FliT;
14-120 5.35e-11

flagella biosynthesis regulatory protein FliT;


Pssm-ID: 182538  Cd Length: 121  Bit Score: 55.38  E-value: 5.35e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1551608680  14 LTQHAPVLEIYQDIANLTSRMLAAANASNWDLVLNHGQEYVCLVERLRELEPGEPLDEAARGMKFDLLVRILENDAAVRD 93
Cdd:PRK10548    1 MNNAPHLLSAWQQILTLSQSMLRLATEGQWDELIEQEVAYVQAVEEIAHLTIPPDISTVMQEQLRPMLRQILDNEAELKQ 80

                          90       100
                  ....*....|....*....|....*..
gi 1551608680  94 LALPQLARLSDLLGRMKRQQSLLATYS 120
Cdd:PRK10548   81 LLQQRMDELSSLIGQSTRQKSVNSAYG 107
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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