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Conserved domains on  [gi|189044181|sp|B1J0Z4|]
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RecName: Full=Sigma factor-binding protein Crl

Protein Classification

sigma factor-binding protein Crl( domain architecture ID 10013694)

sigma factor-binding protein Crl (curlin genes transcriptional activator) binds to the sigma-S subunit of RNA polymerase, activating expression of sigma-S-regulated genes; it stimulates RNA polymerase holoenzyme formation and may bind to several other sigma factors, such as sigma-70 and sigma-32

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK10984 PRK10984
sigma factor-binding protein Crl;
1-127 1.23e-88

sigma factor-binding protein Crl;


:

Pssm-ID: 182882  Cd Length: 127  Bit Score: 252.94  E-value: 1.23e-88
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189044181   1 MTLPSGHPKSRLIKKFTALGPYIREGKCEDNRFFFDCLAVCVNVKPAPEVREFWGWWMELEAQESRFTYSYQFGLFDKAG 80
Cdd:PRK10984   1 MTLPSGHPKSRLIKKFTALGPYLREGQCEENRFFFDCLAVCVNVKPAPEKREFWGWWMELEAQEGRFTYSYQFGLFDKEG 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 189044181  81 DWKSVPVKDTEVVERLEHTLREFHEKLRELLTTLNLKLEPADDFRDE 127
Cdd:PRK10984  81 NWVAEPIKDKEVVERLEHTLREFHEKLRELLATLELKLEPADDFNDE 127
 
Name Accession Description Interval E-value
PRK10984 PRK10984
sigma factor-binding protein Crl;
1-127 1.23e-88

sigma factor-binding protein Crl;


Pssm-ID: 182882  Cd Length: 127  Bit Score: 252.94  E-value: 1.23e-88
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189044181   1 MTLPSGHPKSRLIKKFTALGPYIREGKCEDNRFFFDCLAVCVNVKPAPEVREFWGWWMELEAQESRFTYSYQFGLFDKAG 80
Cdd:PRK10984   1 MTLPSGHPKSRLIKKFTALGPYLREGQCEENRFFFDCLAVCVNVKPAPEKREFWGWWMELEAQEGRFTYSYQFGLFDKEG 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 189044181  81 DWKSVPVKDTEVVERLEHTLREFHEKLRELLTTLNLKLEPADDFRDE 127
Cdd:PRK10984  81 NWVAEPIKDKEVVERLEHTLREFHEKLRELLATLELKLEPADDFNDE 127
Crl pfam07417
Sigma factor-binding transcriptional regulator Crl; This family contains the bacterial Sigma ...
 1-128 5.20e-87

Sigma factor-binding transcriptional regulator Crl; This family contains the bacterial Sigma factor-binding protein Crl (approximately 130 residues long). This is a transcriptional regulator of the csgA curlin subunit gene for curli fibres that are found on the surface of certain bacteria. These proteins bind to the sigma-S subunit of RNA polymerase, activating expression of sigma-S-regulated genes. It was initially suggested that Crl affects transcription initiation in vitro by other sigmas, such as sigma-70 and sigma-32. However, it is now established that Crl binds specifically to the alternative sigma factor S/RpoS and favors its association with the core RNAP (RNA polymerase), thereby increasing its activity, which in turn regulates general stress response that protects many Gram-negative bacteria from several harmful environmental conditions. Furthermore, sigma S factor/RpoS plays important roles in biofilm formation and virulence of the food-borne pathogen Salmonella enterica serovar Typhimurium.


Pssm-ID: 462160  Cd Length: 127  Bit Score: 248.99  E-value: 5.20e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189044181    1 MTLPSGHPKSRLIKKFTALGPYIREGKCEDNRFFFDCLAVCVNVKPAPEVREFWGWWMELEAQESRFTYSYQFGLFDKAG 80
Cdd:pfam07417   1 MTLPSGHPHSRLLKKFTALGPYLREGQCEEGRFFFDCLAVCVNVKPAPEKREFWGWWLELEAQEDGFTYSYHFGLFDKEG 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 189044181   81 DWKSVPVKDTEvVERLEHTLREFHEKLRELLTTLNLKLEPADDFRDEP 128
Cdd:pfam07417  81 NWQEEKIKDKE-QEEVERTLRDFHEKLEALLEEFELTLEPADDFAEEP 127
 
Name Accession Description Interval E-value
PRK10984 PRK10984
sigma factor-binding protein Crl;
1-127 1.23e-88

sigma factor-binding protein Crl;


Pssm-ID: 182882  Cd Length: 127  Bit Score: 252.94  E-value: 1.23e-88
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189044181   1 MTLPSGHPKSRLIKKFTALGPYIREGKCEDNRFFFDCLAVCVNVKPAPEVREFWGWWMELEAQESRFTYSYQFGLFDKAG 80
Cdd:PRK10984   1 MTLPSGHPKSRLIKKFTALGPYLREGQCEENRFFFDCLAVCVNVKPAPEKREFWGWWMELEAQEGRFTYSYQFGLFDKEG 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 189044181  81 DWKSVPVKDTEVVERLEHTLREFHEKLRELLTTLNLKLEPADDFRDE 127
Cdd:PRK10984  81 NWVAEPIKDKEVVERLEHTLREFHEKLRELLATLELKLEPADDFNDE 127
Crl pfam07417
Sigma factor-binding transcriptional regulator Crl; This family contains the bacterial Sigma ...
 1-128 5.20e-87

Sigma factor-binding transcriptional regulator Crl; This family contains the bacterial Sigma factor-binding protein Crl (approximately 130 residues long). This is a transcriptional regulator of the csgA curlin subunit gene for curli fibres that are found on the surface of certain bacteria. These proteins bind to the sigma-S subunit of RNA polymerase, activating expression of sigma-S-regulated genes. It was initially suggested that Crl affects transcription initiation in vitro by other sigmas, such as sigma-70 and sigma-32. However, it is now established that Crl binds specifically to the alternative sigma factor S/RpoS and favors its association with the core RNAP (RNA polymerase), thereby increasing its activity, which in turn regulates general stress response that protects many Gram-negative bacteria from several harmful environmental conditions. Furthermore, sigma S factor/RpoS plays important roles in biofilm formation and virulence of the food-borne pathogen Salmonella enterica serovar Typhimurium.


Pssm-ID: 462160  Cd Length: 127  Bit Score: 248.99  E-value: 5.20e-87
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 189044181    1 MTLPSGHPKSRLIKKFTALGPYIREGKCEDNRFFFDCLAVCVNVKPAPEVREFWGWWMELEAQESRFTYSYQFGLFDKAG 80
Cdd:pfam07417   1 MTLPSGHPHSRLLKKFTALGPYLREGQCEEGRFFFDCLAVCVNVKPAPEKREFWGWWLELEAQEDGFTYSYHFGLFDKEG 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 189044181   81 DWKSVPVKDTEvVERLEHTLREFHEKLRELLTTLNLKLEPADDFRDEP 128
Cdd:pfam07417  81 NWQEEKIKDKE-QEEVERTLRDFHEKLEALLEEFELTLEPADDFAEEP 127
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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