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Conserved domains on  [gi|259710296|sp|B4G7U3|]
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RecName: Full=Zinc finger CCCH-type with G patch domain-containing protein

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
G-patch pfam01585
G-patch domain; This domain is found in a number of RNA binding proteins, and is also found in ...
 310-353 9.99e-15

G-patch domain; This domain is found in a number of RNA binding proteins, and is also found in proteins that contain RNA binding domains. This suggests that this domain may have an RNA binding function. This domain has seven highly conserved glycines.


:

Pssm-ID: 396249 [Multi-domain]  Cd Length: 45  Bit Score: 67.92  E-value: 9.99e-15
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 259710296  310 TRGIGSKLMEKMGYIHGTGLGSEGRGIVTPVSAQILPQGRSLDA 353
Cdd:pfam01585   1 TSNIGFKLLQKMGWKEGQGLGKNEQGIAEPIEAKIKKDRRGLGA 44
Tudor_ZGPAT cd20384
Tudor domain found in zinc finger CCCH-type with G patch domain-containing protein (ZGPAT) and ...
 191-249 3.03e-05

Tudor domain found in zinc finger CCCH-type with G patch domain-containing protein (ZGPAT) and similar proteins; ZGPAT, also called ZIP, G patch domain-containing protein 6 (GPATC6), GPATCH6, zinc finger CCCH domain-containing protein 9 (ZC3HDC9), ZC3H9, or zinc finger and G patch domain-containing protein, is a transcription repressor that specifically binds the 5'-GGAG[GA]A[GA]A-3' consensus sequence. It represses transcription by recruiting the chromatin multiprotein complex NuRD to target promoters. It contains one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


:

Pssm-ID: 410455  Cd Length: 55  Bit Score: 41.44  E-value: 3.03e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 259710296 191 DFPRLARNCPVLAKMPDRLWHRGRVLcaNFVE-QTCRVRLdgqDHKERERDFQFEELFPL 249
Cdd:cd20384    1 DFSSLKEGSRCLAKYDDGLWYPATVT--DIDEdGKYTVKF---DSYGEVAVVELDDILPL 55
ZnF_C3H1 smart00356
zinc finger;
155-176 4.62e-03

zinc finger;


:

Pssm-ID: 214632 [Multi-domain]  Cd Length: 27  Bit Score: 34.53  E-value: 4.62e-03
                           10        20
                   ....*....|....*....|..
gi 259710296   155 PCNYYLEGECRFDEiRCRYSHG 176
Cdd:smart00356   6 LCKFFKRGYCPRGD-RCKFAHP 26
 
Name Accession Description Interval E-value
G-patch pfam01585
G-patch domain; This domain is found in a number of RNA binding proteins, and is also found in ...
 310-353 9.99e-15

G-patch domain; This domain is found in a number of RNA binding proteins, and is also found in proteins that contain RNA binding domains. This suggests that this domain may have an RNA binding function. This domain has seven highly conserved glycines.


Pssm-ID: 396249 [Multi-domain]  Cd Length: 45  Bit Score: 67.92  E-value: 9.99e-15
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 259710296  310 TRGIGSKLMEKMGYIHGTGLGSEGRGIVTPVSAQILPQGRSLDA 353
Cdd:pfam01585   1 TSNIGFKLLQKMGWKEGQGLGKNEQGIAEPIEAKIKKDRRGLGA 44
G_patch smart00443
glycine rich nucleic binding domain; A predicted glycine rich nucleic binding domain found in ...
 310-353 9.25e-11

glycine rich nucleic binding domain; A predicted glycine rich nucleic binding domain found in the splicing factor 45, SON DNA binding protein and D-type Retrovirus- polyproteins.


Pssm-ID: 197727 [Multi-domain]  Cd Length: 47  Bit Score: 56.78  E-value: 9.25e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 259710296   310 TRGIGSKLMEKMGYIHGTGLGSEGRGIVTPVSAQILPQGRSLDA 353
Cdd:smart00443   3 TSNIGAKLLRKMGWKEGQGLGKNEQGIVEPISAEIKKDRKGLGA 46
Tudor_ZGPAT cd20384
Tudor domain found in zinc finger CCCH-type with G patch domain-containing protein (ZGPAT) and ...
 191-249 3.03e-05

Tudor domain found in zinc finger CCCH-type with G patch domain-containing protein (ZGPAT) and similar proteins; ZGPAT, also called ZIP, G patch domain-containing protein 6 (GPATC6), GPATCH6, zinc finger CCCH domain-containing protein 9 (ZC3HDC9), ZC3H9, or zinc finger and G patch domain-containing protein, is a transcription repressor that specifically binds the 5'-GGAG[GA]A[GA]A-3' consensus sequence. It represses transcription by recruiting the chromatin multiprotein complex NuRD to target promoters. It contains one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410455  Cd Length: 55  Bit Score: 41.44  E-value: 3.03e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 259710296 191 DFPRLARNCPVLAKMPDRLWHRGRVLcaNFVE-QTCRVRLdgqDHKERERDFQFEELFPL 249
Cdd:cd20384    1 DFSSLKEGSRCLAKYDDGLWYPATVT--DIDEdGKYTVKF---DSYGEVAVVELDDILPL 55
ZnF_C3H1 smart00356
zinc finger;
155-176 4.62e-03

zinc finger;


Pssm-ID: 214632 [Multi-domain]  Cd Length: 27  Bit Score: 34.53  E-value: 4.62e-03
                           10        20
                   ....*....|....*....|..
gi 259710296   155 PCNYYLEGECRFDEiRCRYSHG 176
Cdd:smart00356   6 LCKFFKRGYCPRGD-RCKFAHP 26
zf_CCCH_4 pfam18345
Zinc finger domain; This is a zinc finger domain found in Zinc finger CCCH-type with G patch ...
 156-175 7.76e-03

Zinc finger domain; This is a zinc finger domain found in Zinc finger CCCH-type with G patch domain-containing proteins such as ZIP. Functional studies indicate that ZIP specifically targets EGFR and represses its transcription, and that the zinc finger and the coiled-coil domains are central to that process.


Pssm-ID: 465719 [Multi-domain]  Cd Length: 19  Bit Score: 33.93  E-value: 7.76e-03
                          10        20
                  ....*....|....*....|
gi 259710296  156 CNYYLEGECRFDEiRCRYSH 175
Cdd:pfam18345   1 CKFFLKGRCRYGD-KCRFAH 19
 
Name Accession Description Interval E-value
G-patch pfam01585
G-patch domain; This domain is found in a number of RNA binding proteins, and is also found in ...
 310-353 9.99e-15

G-patch domain; This domain is found in a number of RNA binding proteins, and is also found in proteins that contain RNA binding domains. This suggests that this domain may have an RNA binding function. This domain has seven highly conserved glycines.


Pssm-ID: 396249 [Multi-domain]  Cd Length: 45  Bit Score: 67.92  E-value: 9.99e-15
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 259710296  310 TRGIGSKLMEKMGYIHGTGLGSEGRGIVTPVSAQILPQGRSLDA 353
Cdd:pfam01585   1 TSNIGFKLLQKMGWKEGQGLGKNEQGIAEPIEAKIKKDRRGLGA 44
G_patch smart00443
glycine rich nucleic binding domain; A predicted glycine rich nucleic binding domain found in ...
 310-353 9.25e-11

glycine rich nucleic binding domain; A predicted glycine rich nucleic binding domain found in the splicing factor 45, SON DNA binding protein and D-type Retrovirus- polyproteins.


Pssm-ID: 197727 [Multi-domain]  Cd Length: 47  Bit Score: 56.78  E-value: 9.25e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 259710296   310 TRGIGSKLMEKMGYIHGTGLGSEGRGIVTPVSAQILPQGRSLDA 353
Cdd:smart00443   3 TSNIGAKLLRKMGWKEGQGLGKNEQGIVEPISAEIKKDRKGLGA 46
Tudor_ZGPAT cd20384
Tudor domain found in zinc finger CCCH-type with G patch domain-containing protein (ZGPAT) and ...
 191-249 3.03e-05

Tudor domain found in zinc finger CCCH-type with G patch domain-containing protein (ZGPAT) and similar proteins; ZGPAT, also called ZIP, G patch domain-containing protein 6 (GPATC6), GPATCH6, zinc finger CCCH domain-containing protein 9 (ZC3HDC9), ZC3H9, or zinc finger and G patch domain-containing protein, is a transcription repressor that specifically binds the 5'-GGAG[GA]A[GA]A-3' consensus sequence. It represses transcription by recruiting the chromatin multiprotein complex NuRD to target promoters. It contains one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410455  Cd Length: 55  Bit Score: 41.44  E-value: 3.03e-05
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 259710296 191 DFPRLARNCPVLAKMPDRLWHRGRVLcaNFVE-QTCRVRLdgqDHKERERDFQFEELFPL 249
Cdd:cd20384    1 DFSSLKEGSRCLAKYDDGLWYPATVT--DIDEdGKYTVKF---DSYGEVAVVELDDILPL 55
ZnF_C3H1 smart00356
zinc finger;
155-176 4.62e-03

zinc finger;


Pssm-ID: 214632 [Multi-domain]  Cd Length: 27  Bit Score: 34.53  E-value: 4.62e-03
                           10        20
                   ....*....|....*....|..
gi 259710296   155 PCNYYLEGECRFDEiRCRYSHG 176
Cdd:smart00356   6 LCKFFKRGYCPRGD-RCKFAHP 26
zf_CCCH_4 pfam18345
Zinc finger domain; This is a zinc finger domain found in Zinc finger CCCH-type with G patch ...
 156-175 7.76e-03

Zinc finger domain; This is a zinc finger domain found in Zinc finger CCCH-type with G patch domain-containing proteins such as ZIP. Functional studies indicate that ZIP specifically targets EGFR and represses its transcription, and that the zinc finger and the coiled-coil domains are central to that process.


Pssm-ID: 465719 [Multi-domain]  Cd Length: 19  Bit Score: 33.93  E-value: 7.76e-03
                          10        20
                  ....*....|....*....|
gi 259710296  156 CNYYLEGECRFDEiRCRYSH 175
Cdd:pfam18345   1 CKFFLKGRCRYGD-KCRFAH 19
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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