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Conserved domains on  [gi|259511457|sp|B4J497|]
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RecName: Full=Serrate RNA effector molecule homolog; AltName: Full=Arsenite-resistance protein 2 homolog

Protein Classification

DUF3546 and ARS2 domain-containing protein( domain architecture ID 10572492)

DUF3546 and ARS2 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ARS2 super family cl20283
Arsenite-resistance protein 2; Arsenite is a carcinogenic compound which can act as a ...
 814-964 3.76e-57

Arsenite-resistance protein 2; Arsenite is a carcinogenic compound which can act as a co-mutagen by inhibiting DNA repair. Arsenite-resistance protein 2 is thought to play a role in arsenite resistance.


The actual alignment was detected with superfamily member pfam04959:

Pssm-ID: 461498  Cd Length: 195  Bit Score: 195.49  E-value: 3.76e-57
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259511457   814 RGPAPM-RVTSNDVQEYIKSYEGKLQQFLAKTVQLSDENIKELGAKNPEKEVEKFVQANTQELAKDKWLCPLSGKKFKGP 892
Cdd:pfam04959    1 RGPGPSgRITSAEVVEWQKGFEERLEPLLSEKETLSEEEAMKMGKKDPEQEVEKFVRKNTQELAKDKWLCPLSGKKFKGP 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259511457   893 EFIRKHIFNKHEEKVDEVRKEVQYFNNYLRDPKRPQLPEH-----PGSSKRTESES----------GRGSGGYRPPM--- 954
Cdd:pfam04959   81 EFVRKHILNKHGDKVEEVRSEVEFFNNYLADAKRPATPELkpkppPRPANRRERPGrafpsqrpqgQMSDGHPRPPMdgp 160

                          170
                   ....*....|..
gi 259511457   955 --YPPFSAMPYG 964
Cdd:pfam04959  161 ggGPPFPPNQYG 172
SERRATE_Ars2_N pfam12066
SERRATE/Ars2, N-terminal domain; This domain can be found in the N terminus of the SERRATE (SE) ...
 171-280 8.35e-46

SERRATE/Ars2, N-terminal domain; This domain can be found in the N terminus of the SERRATE (SE) from plants and its homolog, Ars2, from animals. They play a role in nuclear RNA metabolism. They interact with the nuclear cap-binding complex (CBC) and mediates interactions with diverse RNA processing and transport machineries in a transcript-dependent manner. Interestingly, the plant SERRATE does not have the RNA recognition motif (RRM) domain found in metazoans and S. pombe. This domain has two completely conserved Y residues that may be functionally important.


:

Pssm-ID: 463453 [Multi-domain]  Cd Length: 110  Bit Score: 159.71  E-value: 8.35e-46
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259511457   171 KQFLDTQDENISDSEVMRKYTEYKTDFKRQQLNEFFVAHKDEEWFKNKYHPEDSVRRSDEQRGFLKRRTDVFLELLNNGT 250
Cdd:pfam12066    1 KQFLESQEDDIEDEEAQKKYDEYKLEFQRKQANEFFVAHKDEEWFKEKYHPEERDKRREELREFRRKRLEVFEEDLESGV 80

                           90       100       110
                   ....*....|....*....|....*....|
gi 259511457   251 ISNVKVDSSQADALVRVLDTCVIKLEGGTD 280
Cdd:pfam12066   81 FDEVSLDMGIYKSESKLLDGVVIKEEGGTD 110
 
Name Accession Description Interval E-value
ARS2 pfam04959
Arsenite-resistance protein 2; Arsenite is a carcinogenic compound which can act as a ...
 814-964 3.76e-57

Arsenite-resistance protein 2; Arsenite is a carcinogenic compound which can act as a co-mutagen by inhibiting DNA repair. Arsenite-resistance protein 2 is thought to play a role in arsenite resistance.


Pssm-ID: 461498  Cd Length: 195  Bit Score: 195.49  E-value: 3.76e-57
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259511457   814 RGPAPM-RVTSNDVQEYIKSYEGKLQQFLAKTVQLSDENIKELGAKNPEKEVEKFVQANTQELAKDKWLCPLSGKKFKGP 892
Cdd:pfam04959    1 RGPGPSgRITSAEVVEWQKGFEERLEPLLSEKETLSEEEAMKMGKKDPEQEVEKFVRKNTQELAKDKWLCPLSGKKFKGP 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259511457   893 EFIRKHIFNKHEEKVDEVRKEVQYFNNYLRDPKRPQLPEH-----PGSSKRTESES----------GRGSGGYRPPM--- 954
Cdd:pfam04959   81 EFVRKHILNKHGDKVEEVRSEVEFFNNYLADAKRPATPELkpkppPRPANRRERPGrafpsqrpqgQMSDGHPRPPMdgp 160

                          170
                   ....*....|..
gi 259511457   955 --YPPFSAMPYG 964
Cdd:pfam04959  161 ggGPPFPPNQYG 172
SERRATE_Ars2_N pfam12066
SERRATE/Ars2, N-terminal domain; This domain can be found in the N terminus of the SERRATE (SE) ...
 171-280 8.35e-46

SERRATE/Ars2, N-terminal domain; This domain can be found in the N terminus of the SERRATE (SE) from plants and its homolog, Ars2, from animals. They play a role in nuclear RNA metabolism. They interact with the nuclear cap-binding complex (CBC) and mediates interactions with diverse RNA processing and transport machineries in a transcript-dependent manner. Interestingly, the plant SERRATE does not have the RNA recognition motif (RRM) domain found in metazoans and S. pombe. This domain has two completely conserved Y residues that may be functionally important.


Pssm-ID: 463453 [Multi-domain]  Cd Length: 110  Bit Score: 159.71  E-value: 8.35e-46
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259511457   171 KQFLDTQDENISDSEVMRKYTEYKTDFKRQQLNEFFVAHKDEEWFKNKYHPEDSVRRSDEQRGFLKRRTDVFLELLNNGT 250
Cdd:pfam12066    1 KQFLESQEDDIEDEEAQKKYDEYKLEFQRKQANEFFVAHKDEEWFKEKYHPEERDKRREELREFRRKRLEVFEEDLESGV 80

                           90       100       110
                   ....*....|....*....|....*....|
gi 259511457   251 ISNVKVDSSQADALVRVLDTCVIKLEGGTD 280
Cdd:pfam12066   81 FDEVSLDMGIYKSESKLLDGVVIKEEGGTD 110
 
Name Accession Description Interval E-value
ARS2 pfam04959
Arsenite-resistance protein 2; Arsenite is a carcinogenic compound which can act as a ...
 814-964 3.76e-57

Arsenite-resistance protein 2; Arsenite is a carcinogenic compound which can act as a co-mutagen by inhibiting DNA repair. Arsenite-resistance protein 2 is thought to play a role in arsenite resistance.


Pssm-ID: 461498  Cd Length: 195  Bit Score: 195.49  E-value: 3.76e-57
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259511457   814 RGPAPM-RVTSNDVQEYIKSYEGKLQQFLAKTVQLSDENIKELGAKNPEKEVEKFVQANTQELAKDKWLCPLSGKKFKGP 892
Cdd:pfam04959    1 RGPGPSgRITSAEVVEWQKGFEERLEPLLSEKETLSEEEAMKMGKKDPEQEVEKFVRKNTQELAKDKWLCPLSGKKFKGP 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259511457   893 EFIRKHIFNKHEEKVDEVRKEVQYFNNYLRDPKRPQLPEH-----PGSSKRTESES----------GRGSGGYRPPM--- 954
Cdd:pfam04959   81 EFVRKHILNKHGDKVEEVRSEVEFFNNYLADAKRPATPELkpkppPRPANRRERPGrafpsqrpqgQMSDGHPRPPMdgp 160

                          170
                   ....*....|..
gi 259511457   955 --YPPFSAMPYG 964
Cdd:pfam04959  161 ggGPPFPPNQYG 172
SERRATE_Ars2_N pfam12066
SERRATE/Ars2, N-terminal domain; This domain can be found in the N terminus of the SERRATE (SE) ...
 171-280 8.35e-46

SERRATE/Ars2, N-terminal domain; This domain can be found in the N terminus of the SERRATE (SE) from plants and its homolog, Ars2, from animals. They play a role in nuclear RNA metabolism. They interact with the nuclear cap-binding complex (CBC) and mediates interactions with diverse RNA processing and transport machineries in a transcript-dependent manner. Interestingly, the plant SERRATE does not have the RNA recognition motif (RRM) domain found in metazoans and S. pombe. This domain has two completely conserved Y residues that may be functionally important.


Pssm-ID: 463453 [Multi-domain]  Cd Length: 110  Bit Score: 159.71  E-value: 8.35e-46
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 259511457   171 KQFLDTQDENISDSEVMRKYTEYKTDFKRQQLNEFFVAHKDEEWFKNKYHPEDSVRRSDEQRGFLKRRTDVFLELLNNGT 250
Cdd:pfam12066    1 KQFLESQEDDIEDEEAQKKYDEYKLEFQRKQANEFFVAHKDEEWFKEKYHPEERDKRREELREFRRKRLEVFEEDLESGV 80

                           90       100       110
                   ....*....|....*....|....*....|
gi 259511457   251 ISNVKVDSSQADALVRVLDTCVIKLEGGTD 280
Cdd:pfam12066   81 FDEVSLDMGIYKSESKLLDGVVIKEEGGTD 110
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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