NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|226710582|sp|B7M846|]
View 

RecName: Full=UPF0434 protein YcaR

Protein Classification

Trm112 family protein( domain architecture ID 10013883)

Trm112 family protein such as Homo sapiens mitochondrial protein PreY

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
PRK11827 PRK11827
protein YcaR;
1-60 2.50e-39

protein YcaR;


:

Pssm-ID: 183328  Cd Length: 60  Bit Score: 123.18  E-value: 2.50e-39
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 226710582  1 MDHRLLEIIACPVCNGKLWYNQEKQELICKLDNLAFPLRDGIPVLLETEARVLTADESKS 60
Cdd:PRK11827  1 MDHRLLEIIACPVCNGKLWYNQEKQELICKLDNLAFPLRDGIPVLLETEARVLTADESKS 60
 
Name Accession Description Interval E-value
PRK11827 PRK11827
protein YcaR;
1-60 2.50e-39

protein YcaR;


Pssm-ID: 183328  Cd Length: 60  Bit Score: 123.18  E-value: 2.50e-39
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 226710582  1 MDHRLLEIIACPVCNGKLWYNQEKQELICKLDNLAFPLRDGIPVLLETEARVLTADESKS 60
Cdd:PRK11827  1 MDHRLLEIIACPVCNGKLWYNQEKQELICKLDNLAFPLRDGIPVLLETEARVLTADESKS 60
Trm112 COG2835
RNA methyltransferase activator Trm112/YbaR [Translation, ribosomal structure and biogenesis];
1-60 2.47e-27

RNA methyltransferase activator Trm112/YbaR [Translation, ribosomal structure and biogenesis];


Pssm-ID: 442083 [Multi-domain]  Cd Length: 60  Bit Score: 92.64  E-value: 2.47e-27
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 226710582  1 MDHRLLEIIACPVCNGKLWYNQEKQELICKLDNLAFPLRDGIPVLLETEARVLTADESKS 60
Cdd:COG2835   1 MDPRLLEILACPVCKGPLELDKEEGELVCTACGLAYPIRDGIPVLLPDEARPLSEDEEFS 60
Trm112p pfam03966
Trm112p-like protein; The function of this family is uncertain. The bacterial members are ...
 2-41 3.44e-11

Trm112p-like protein; The function of this family is uncertain. The bacterial members are about 60-70 amino acids in length and the eukaryotic examples are about 120 amino acids in length. The C terminus contains the strongest conservation. Trm112p is required for tRNA methylation in S. cerevisiae and is found in complexes with 2 tRNA methylases (TRM9 and TRM11) also with putative methyltransferase YDR140W. The zinc-finger protein Ynr046w is plurifunctional and a component of the eRF1 methyltransferase in yeast. The crystal structure of Ynr046w has been determined to 1.7 A resolution. It comprises a zinc-binding domain built from both the N- and C-terminal sequences and an inserted domain, absent from bacterial and archaeal orthologs of the protein, composed of three alpha-helices.


Pssm-ID: 397869  Cd Length: 44  Bit Score: 51.78  E-value: 3.44e-11
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 226710582   2 DHRLLEIIACPVCNGKLW----YNQEKQELICKLDNLAFPLRDG 41
Cdd:pfam03966  1 DLLLLEILACPLCKGPLHllleYDIEEGELVCPECGLAYPIRDG 44
 
Name Accession Description Interval E-value
PRK11827 PRK11827
protein YcaR;
1-60 2.50e-39

protein YcaR;


Pssm-ID: 183328  Cd Length: 60  Bit Score: 123.18  E-value: 2.50e-39
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 226710582  1 MDHRLLEIIACPVCNGKLWYNQEKQELICKLDNLAFPLRDGIPVLLETEARVLTADESKS 60
Cdd:PRK11827  1 MDHRLLEIIACPVCNGKLWYNQEKQELICKLDNLAFPLRDGIPVLLETEARVLTADESKS 60
Trm112 COG2835
RNA methyltransferase activator Trm112/YbaR [Translation, ribosomal structure and biogenesis];
1-60 2.47e-27

RNA methyltransferase activator Trm112/YbaR [Translation, ribosomal structure and biogenesis];


Pssm-ID: 442083 [Multi-domain]  Cd Length: 60  Bit Score: 92.64  E-value: 2.47e-27
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 226710582  1 MDHRLLEIIACPVCNGKLWYNQEKQELICKLDNLAFPLRDGIPVLLETEARVLTADESKS 60
Cdd:COG2835   1 MDPRLLEILACPVCKGPLELDKEEGELVCTACGLAYPIRDGIPVLLPDEARPLSEDEEFS 60
Trm112p pfam03966
Trm112p-like protein; The function of this family is uncertain. The bacterial members are ...
 2-41 3.44e-11

Trm112p-like protein; The function of this family is uncertain. The bacterial members are about 60-70 amino acids in length and the eukaryotic examples are about 120 amino acids in length. The C terminus contains the strongest conservation. Trm112p is required for tRNA methylation in S. cerevisiae and is found in complexes with 2 tRNA methylases (TRM9 and TRM11) also with putative methyltransferase YDR140W. The zinc-finger protein Ynr046w is plurifunctional and a component of the eRF1 methyltransferase in yeast. The crystal structure of Ynr046w has been determined to 1.7 A resolution. It comprises a zinc-binding domain built from both the N- and C-terminal sequences and an inserted domain, absent from bacterial and archaeal orthologs of the protein, composed of three alpha-helices.


Pssm-ID: 397869  Cd Length: 44  Bit Score: 51.78  E-value: 3.44e-11
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 226710582   2 DHRLLEIIACPVCNGKLW----YNQEKQELICKLDNLAFPLRDG 41
Cdd:pfam03966  1 DLLLLEILACPLCKGPLHllleYDIEEGELVCPECGLAYPIRDG 44
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH