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Conserved domains on  [gi|929653742|dbj|BAA02801|]
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KIAA0012 [Homo sapiens]

Protein Classification

toll-like receptor( domain architecture ID 11471523)

toll-like receptor (TLR) is involved in the recognition of microbial pathogens by the innate immune system, which recognize different pathogen-associated molecular patterns

CATH:  3.40.50.10140|3.80.10.10
Gene Ontology:  GO:0005515|GO:0002224|GO:0006955|GO:0004888|GO:0038187
PubMed:  18227810|16675322|34199501|16822173|11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TIR smart00255
Toll - interleukin 1 - resistance;
636-779 1.56e-40

Toll - interleukin 1 - resistance;


:

Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 145.54  E-value: 1.56e-40
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929653742   636 QFHAFISYSGHDsfWVKNELLPNLEK--EGMQICLHERNFVPGKSIVENIITCIEKSYKSIFVLSPNFVQSEWCHYELYF 713
Cdd:smart00255   1 EYDVFISYSGKE--DVRNEFLSHLLEklRGYGLCVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYAESEWCLDELVA 78

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 929653742   714 AHHNLFHEGSNSLILILLEPIPQYsIPSSYHKLKSLMaRRTYLEWPKEKSKRglFWANLRAAINIK 779
Cdd:smart00255  79 ALENALEEGGLRVIPIFYEVIPSD-VRKQPGKFRKVF-KKNYLKWPEDEKEQ--FWKKALYAVPSK 140
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
215-526 3.17e-15

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 78.82  E-value: 3.17e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929653742 215 NLELSNIKCVLEDNKCSYFLSILAKLQTNPKLSNLTLNNIETTWNSFIRILQLVWHTTVWYFSISNVKLQGQLDFRDFDY 294
Cdd:COG4886    3 LLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929653742 295 SGTSLKALSIHQVVSDVFgFPQSYIYEIFSNMNIKNFTVSGTRMVHMlcPSKISPFLHL---DFSNNLLTDtVFENCGHL 371
Cdd:COG4886   83 SLLLLGLTDLGDLTNLTE-LDLSGNEELSNLTNLESLDLSGNQLTDL--PEELANLTNLkelDLSNNQLTD-LPEPLGNL 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929653742 372 TELETLILQMNQLKELSKIAEmttQMKSLQQLDISQNSVSYdekkgdcswtksllslnmssniLTDTIFRClpPRIKVLD 451
Cdd:COG4886  159 TNLKSLDLSNNQLTDLPEELG---NLTNLKELDLSNNQITD----------------------LPEPLGNL--TNLEELD 211

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 929653742 452 LHSNKIKSIPKQVVKLEALQELNVAFNSLTDLPGCGSFSSLSVLIIDHNSVSHPSadFFQSCQKMRSIKAGDNPF 526
Cdd:COG4886  212 LSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLP--PLANLTNLKTLDLSNNQL 284
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
32-273 6.12e-11

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 65.34  E-value: 6.12e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929653742  32 SKNGLIHVPKDLSQ--KTTILNISQNYISELwTSDILSLSKLRILIISHNTIQYLDISVFKFNQeLEYLDLSHNKLVKIs 109
Cdd:COG4886  167 SNNQLTDLPEELGNltNLKELDLSNNQITDL-PEPLGNLTNLEELDLSGNQLTDLPEPLANLTN-LETLDLSNNQLTDL- 243

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929653742 110 chPTV----NLKHLDLSFNAFDALPICKEFGNMSQLKFLG--LSTTHLEKSSVLPIAHLNISKVLLVLGETYGEKEDPEG 183
Cdd:COG4886  244 --PELgnltNLEELDLSNNQLTDLPPLANLTNLKTLDLSNnqLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLT 321

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929653742 184 LQDFNTESLHIVFPTNKEFHFILDVSVKTVANLELSNIKCVLEDNKCSYFLSILAKLQTNPKLSNLTLNNIETTWNSFIR 263
Cdd:COG4886  322 TLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVL 401

                        250
                 ....*....|
gi 929653742 264 ILQLVWHTTV 273
Cdd:COG4886  402 LLTLALLDAV 411
LRRCT smart00082
Leucine rich repeat C-terminal domain;
524-577 4.64e-08

Leucine rich repeat C-terminal domain;


:

Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 50.12  E-value: 4.64e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 929653742   524 NPFQCTCELGEFVKNIDQvssEVLEGWPDSYKCDYPESYRGtLLKDFHMSELSC 577
Cdd:smart00082   1 NPFICDCELRWLLRWLQA---NEHLQDPVDLRCASPSSLRG-PLLELLHSEFKC 50
 
Name Accession Description Interval E-value
TIR smart00255
Toll - interleukin 1 - resistance;
636-779 1.56e-40

Toll - interleukin 1 - resistance;


Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 145.54  E-value: 1.56e-40
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929653742   636 QFHAFISYSGHDsfWVKNELLPNLEK--EGMQICLHERNFVPGKSIVENIITCIEKSYKSIFVLSPNFVQSEWCHYELYF 713
Cdd:smart00255   1 EYDVFISYSGKE--DVRNEFLSHLLEklRGYGLCVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYAESEWCLDELVA 78

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 929653742   714 AHHNLFHEGSNSLILILLEPIPQYsIPSSYHKLKSLMaRRTYLEWPKEKSKRglFWANLRAAINIK 779
Cdd:smart00255  79 ALENALEEGGLRVIPIFYEVIPSD-VRKQPGKFRKVF-KKNYLKWPEDEKEQ--FWKKALYAVPSK 140
TIR pfam01582
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ...
 637-781 2.49e-24

TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.


Pssm-ID: 396246 [Multi-domain]  Cd Length: 165  Bit Score: 100.13  E-value: 2.49e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929653742  637 FHAFISYSGHDSF-WVKNELLPNLEKEGMQICLHERNFVPGKSIVENIITCIEKSYKSIFVLSPNFVQSEWCHYELYFAH 715
Cdd:pfam01582   1 YDVFLSFRGSDTReWFVSHLLKELKQKGIKLFIDDRDLEPGEAIAPELLSAIEKSRRSVVVLSPNYASSGWCLDELVKIL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929653742  716 HNLFHEGSNsLILILLEPIPQY------SIPSSYHKLKSLMARRTYLEWP------------KEKSKRGLFWANLRAAIN 777
Cdd:pfam01582  81 ECALDLGQK-VIPIFYEVDPSDvrkqtgSFGKAFKKHKKVLTEEKVLKWRgalnevaniwhsKSVSDESKFWKKIAYDIS 159


                  ....
gi 929653742  778 IKLT 781
Cdd:pfam01582 160 NKLN 163
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
215-526 3.17e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 78.82  E-value: 3.17e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929653742 215 NLELSNIKCVLEDNKCSYFLSILAKLQTNPKLSNLTLNNIETTWNSFIRILQLVWHTTVWYFSISNVKLQGQLDFRDFDY 294
Cdd:COG4886    3 LLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929653742 295 SGTSLKALSIHQVVSDVFgFPQSYIYEIFSNMNIKNFTVSGTRMVHMlcPSKISPFLHL---DFSNNLLTDtVFENCGHL 371
Cdd:COG4886   83 SLLLLGLTDLGDLTNLTE-LDLSGNEELSNLTNLESLDLSGNQLTDL--PEELANLTNLkelDLSNNQLTD-LPEPLGNL 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929653742 372 TELETLILQMNQLKELSKIAEmttQMKSLQQLDISQNSVSYdekkgdcswtksllslnmssniLTDTIFRClpPRIKVLD 451
Cdd:COG4886  159 TNLKSLDLSNNQLTDLPEELG---NLTNLKELDLSNNQITD----------------------LPEPLGNL--TNLEELD 211

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 929653742 452 LHSNKIKSIPKQVVKLEALQELNVAFNSLTDLPGCGSFSSLSVLIIDHNSVSHPSadFFQSCQKMRSIKAGDNPF 526
Cdd:COG4886  212 LSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLP--PLANLTNLKTLDLSNNQL 284
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
32-273 6.12e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 65.34  E-value: 6.12e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929653742  32 SKNGLIHVPKDLSQ--KTTILNISQNYISELwTSDILSLSKLRILIISHNTIQYLDISVFKFNQeLEYLDLSHNKLVKIs 109
Cdd:COG4886  167 SNNQLTDLPEELGNltNLKELDLSNNQITDL-PEPLGNLTNLEELDLSGNQLTDLPEPLANLTN-LETLDLSNNQLTDL- 243

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929653742 110 chPTV----NLKHLDLSFNAFDALPICKEFGNMSQLKFLG--LSTTHLEKSSVLPIAHLNISKVLLVLGETYGEKEDPEG 183
Cdd:COG4886  244 --PELgnltNLEELDLSNNQLTDLPPLANLTNLKTLDLSNnqLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLT 321

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929653742 184 LQDFNTESLHIVFPTNKEFHFILDVSVKTVANLELSNIKCVLEDNKCSYFLSILAKLQTNPKLSNLTLNNIETTWNSFIR 263
Cdd:COG4886  322 TLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVL 401

                        250
                 ....*....|
gi 929653742 264 ILQLVWHTTV 273
Cdd:COG4886  402 LLTLALLDAV 411
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 352-560 3.10e-10

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 64.10  E-value: 3.10e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929653742 352 HLDFSNNLLTDTVFENCGHLTELETLILQMNQLKelSKIAEMTTQMKSLQQLDISQNSVSyDEKKGDCSWTKSLLSLNMS 431
Cdd:PLN00113 240 HLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLS--GPIPPSIFSLQKLISLDLSDNSLS-GEIPELVIQLQNLEILHLF 316

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929653742 432 SNILTDTIFRCLP--PRIKVLDLHSNKIK-SIPKQVVKLEALQELNVAFNSLT-DLP-GCGSFSSLSVLIIDHNSVSHPS 506
Cdd:PLN00113 317 SNNFTGKIPVALTslPRLQVLQLWSNKFSgEIPKNLGKHNNLTVLDLSTNNLTgEIPeGLCSSGNLFKLILFSNSLEGEI 396

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 929653742 507 ADFFQSCQKMRSIKAGDNPFqcTCEL-GEFVK----NIDQVSSEVLEGWPDSYKCDYPE 560
Cdd:PLN00113 397 PKSLGACRSLRRVRLQDNSF--SGELpSEFTKlplvYFLDISNNNLQGRINSRKWDMPS 453
LRRCT smart00082
Leucine rich repeat C-terminal domain;
524-577 4.64e-08

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 50.12  E-value: 4.64e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 929653742   524 NPFQCTCELGEFVKNIDQvssEVLEGWPDSYKCDYPESYRGtLLKDFHMSELSC 577
Cdd:smart00082   1 NPFICDCELRWLLRWLQA---NEHLQDPVDLRCASPSSLRG-PLLELLHSEFKC 50
LRR_8 pfam13855
Leucine rich repeat;
69-126 1.97e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 48.29  E-value: 1.97e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 929653742   69 SKLRILIISHNTIQYLDISVFKFNQELEYLDLSHNKLVKIS---CHPTVNLKHLDLSFNAF 126
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSpgaFSGLPSLRYLDLSGNRL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 353-474 9.24e-06

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 48.51  E-value: 9.24e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929653742 353 LDFSNNLLTD----TVFENCGHLTELETLILQMNQL--KELSKIAEMTTQMKSLQQLDISQNSVS----YDEKKGDCSWT 422
Cdd:cd00116  170 LNLANNGIGDagirALAEGLKANCNLEVLDLNNNGLtdEGASALAETLASLKSLEVLNLGDNNLTdagaAALASALLSPN 249

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 929653742 423 KSLLSLNMSSNILTDTIFRCL------PPRIKVLDLHSNKIKSIPKQVVKLEALQELN 474
Cdd:cd00116  250 ISLLTLSLSCNDITDDGAKDLaevlaeKESLLELDLRGNKFGEEGAQLLAESLLEPGN 307
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
33-130 1.79e-04

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 45.07  E-value: 1.79e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929653742  33 KNGLIHVPKDLSQKTTILNISQNYISELwtSDILSlSKLRILIISHNTIQYLDISVfkfNQELEYLDLSHNKLVKISCHP 112
Cdd:PRK15370 229 SNQLTSIPATLPDTIQEMELSINRITEL--PERLP-SALQSLDLFHNKISCLPENL---PEELRYLSVYDNSIRTLPAHL 302

                         90
                 ....*....|....*...
gi 929653742 113 TVNLKHLDLSFNAFDALP 130
Cdd:PRK15370 303 PSGITHLNVQSNSLTALP 320
LRRCT pfam01463
Leucine rich repeat C-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 553-577 1.44e-03

Leucine rich repeat C-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the C-terminus of tandem leucine rich repeats.


Pssm-ID: 279765  Cd Length: 26  Bit Score: 36.65  E-value: 1.44e-03
                          10        20
                  ....*....|....*....|....*
gi 929653742  553 SYKCDYPESYRGTLLKDFHMSELSC 577
Cdd:pfam01463   1 NARCASPPRLRGQPLLDLLPSDFSC 25
LRR_8 pfam13855
Leucine rich repeat;
445-500 1.56e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.50  E-value: 1.56e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 929653742  445 PRIKVLDLHSNKIKSIPKQV-VKLEALQELNVAFNSLTDLPGcGSFS---SLSVLIIDHN 500
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAfKGLSNLKVLDLSNNLLTTLSP-GAFSglpSLRYLDLSGN 59
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 43-109 3.01e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 39.77  E-value: 3.01e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 929653742  43 LSQKTTILNISQNYISELwtSDILSLSKLRILIISHNTIQYLD--ISVFKFNQELEYLDLSHNKLVKIS 109
Cdd:cd21340  118 LSNSLRVLNISGNNIDSL--EPLAPLRNLEQLDASNNQISDLEelLDLLSSWPSLRELDLTGNPVCKKP 184
 
Name Accession Description Interval E-value
TIR smart00255
Toll - interleukin 1 - resistance;
636-779 1.56e-40

Toll - interleukin 1 - resistance;


Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 145.54  E-value: 1.56e-40
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929653742   636 QFHAFISYSGHDsfWVKNELLPNLEK--EGMQICLHERNFVPGKSIVENIITCIEKSYKSIFVLSPNFVQSEWCHYELYF 713
Cdd:smart00255   1 EYDVFISYSGKE--DVRNEFLSHLLEklRGYGLCVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYAESEWCLDELVA 78

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 929653742   714 AHHNLFHEGSNSLILILLEPIPQYsIPSSYHKLKSLMaRRTYLEWPKEKSKRglFWANLRAAINIK 779
Cdd:smart00255  79 ALENALEEGGLRVIPIFYEVIPSD-VRKQPGKFRKVF-KKNYLKWPEDEKEQ--FWKKALYAVPSK 140
TIR pfam01582
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ...
 637-781 2.49e-24

TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.


Pssm-ID: 396246 [Multi-domain]  Cd Length: 165  Bit Score: 100.13  E-value: 2.49e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929653742  637 FHAFISYSGHDSF-WVKNELLPNLEKEGMQICLHERNFVPGKSIVENIITCIEKSYKSIFVLSPNFVQSEWCHYELYFAH 715
Cdd:pfam01582   1 YDVFLSFRGSDTReWFVSHLLKELKQKGIKLFIDDRDLEPGEAIAPELLSAIEKSRRSVVVLSPNYASSGWCLDELVKIL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929653742  716 HNLFHEGSNsLILILLEPIPQY------SIPSSYHKLKSLMARRTYLEWP------------KEKSKRGLFWANLRAAIN 777
Cdd:pfam01582  81 ECALDLGQK-VIPIFYEVDPSDvrkqtgSFGKAFKKHKKVLTEEKVLKWRgalnevaniwhsKSVSDESKFWKKIAYDIS 159


                  ....
gi 929653742  778 IKLT 781
Cdd:pfam01582 160 NKLN 163
TIR_2 pfam13676
TIR domain; This is a family of Toll-like receptors.
 640-733 1.43e-16

TIR domain; This is a family of Toll-like receptors.


Pssm-ID: 463954 [Multi-domain]  Cd Length: 118  Bit Score: 76.20  E-value: 1.43e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929653742  640 FISYSGHDSFWVKnELLPNLEKEGMQICLHERNFVPGKSIVENIITCIEKSYKSIFVLSPNFVQSEWCHYELYFAHHnlF 719
Cdd:pfam13676   2 FISYAGEDRAWAE-WLADALEAAGYRVWLDRWDIRPGDDWVEEIEEAIENSDRVLVVLSPNYLESPWCRAEWEAALA--D 78

                          90
                  ....*....|....
gi 929653742  720 HEGSNSLILILLEP 733
Cdd:pfam13676  79 PEGRKRLIPVRLEC 92
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
215-526 3.17e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 78.82  E-value: 3.17e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929653742 215 NLELSNIKCVLEDNKCSYFLSILAKLQTNPKLSNLTLNNIETTWNSFIRILQLVWHTTVWYFSISNVKLQGQLDFRDFDY 294
Cdd:COG4886    3 LLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLL 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929653742 295 SGTSLKALSIHQVVSDVFgFPQSYIYEIFSNMNIKNFTVSGTRMVHMlcPSKISPFLHL---DFSNNLLTDtVFENCGHL 371
Cdd:COG4886   83 SLLLLGLTDLGDLTNLTE-LDLSGNEELSNLTNLESLDLSGNQLTDL--PEELANLTNLkelDLSNNQLTD-LPEPLGNL 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929653742 372 TELETLILQMNQLKELSKIAEmttQMKSLQQLDISQNSVSYdekkgdcswtksllslnmssniLTDTIFRClpPRIKVLD 451
Cdd:COG4886  159 TNLKSLDLSNNQLTDLPEELG---NLTNLKELDLSNNQITD----------------------LPEPLGNL--TNLEELD 211

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 929653742 452 LHSNKIKSIPKQVVKLEALQELNVAFNSLTDLPGCGSFSSLSVLIIDHNSVSHPSadFFQSCQKMRSIKAGDNPF 526
Cdd:COG4886  212 LSGNQLTDLPEPLANLTNLETLDLSNNQLTDLPELGNLTNLEELDLSNNQLTDLP--PLANLTNLKTLDLSNNQL 284
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
32-273 6.12e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 65.34  E-value: 6.12e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929653742  32 SKNGLIHVPKDLSQ--KTTILNISQNYISELwTSDILSLSKLRILIISHNTIQYLDISVFKFNQeLEYLDLSHNKLVKIs 109
Cdd:COG4886  167 SNNQLTDLPEELGNltNLKELDLSNNQITDL-PEPLGNLTNLEELDLSGNQLTDLPEPLANLTN-LETLDLSNNQLTDL- 243

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929653742 110 chPTV----NLKHLDLSFNAFDALPICKEFGNMSQLKFLG--LSTTHLEKSSVLPIAHLNISKVLLVLGETYGEKEDPEG 183
Cdd:COG4886  244 --PELgnltNLEELDLSNNQLTDLPPLANLTNLKTLDLSNnqLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLT 321

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929653742 184 LQDFNTESLHIVFPTNKEFHFILDVSVKTVANLELSNIKCVLEDNKCSYFLSILAKLQTNPKLSNLTLNNIETTWNSFIR 263
Cdd:COG4886  322 TLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVL 401

                        250
                 ....*....|
gi 929653742 264 ILQLVWHTTV 273
Cdd:COG4886  402 LLTLALLDAV 411
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 352-560 3.10e-10

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 64.10  E-value: 3.10e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929653742 352 HLDFSNNLLTDTVFENCGHLTELETLILQMNQLKelSKIAEMTTQMKSLQQLDISQNSVSyDEKKGDCSWTKSLLSLNMS 431
Cdd:PLN00113 240 HLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLS--GPIPPSIFSLQKLISLDLSDNSLS-GEIPELVIQLQNLEILHLF 316

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929653742 432 SNILTDTIFRCLP--PRIKVLDLHSNKIK-SIPKQVVKLEALQELNVAFNSLT-DLP-GCGSFSSLSVLIIDHNSVSHPS 506
Cdd:PLN00113 317 SNNFTGKIPVALTslPRLQVLQLWSNKFSgEIPKNLGKHNNLTVLDLSTNNLTgEIPeGLCSSGNLFKLILFSNSLEGEI 396

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 929653742 507 ADFFQSCQKMRSIKAGDNPFqcTCEL-GEFVK----NIDQVSSEVLEGWPDSYKCDYPE 560
Cdd:PLN00113 397 PKSLGACRSLRRVRLQDNSF--SGELpSEFTKlplvYFLDISNNNLQGRINSRKWDMPS 453
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
45-152 5.01e-10

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 62.26  E-value: 5.01e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929653742  45 QKTTILNISQNYISELwTSDILSLSKLRILIISHNTIQYLDISVFKFNQeLEYLDLSHNKLVKISCH--PTVNLKHLDLS 122
Cdd:COG4886  113 TNLESLDLSGNQLTDL-PEELANLTNLKELDLSNNQLTDLPEPLGNLTN-LKSLDLSNNQLTDLPEElgNLTNLKELDLS 190

                         90       100       110
                 ....*....|....*....|....*....|
gi 929653742 123 FNAFDALPicKEFGNMSQLKFLGLSTTHLE 152
Cdd:COG4886  191 NNQITDLP--EPLGNLTNLEELDLSGNQLT 218
LRRCT smart00082
Leucine rich repeat C-terminal domain;
524-577 4.64e-08

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 50.12  E-value: 4.64e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 929653742   524 NPFQCTCELGEFVKNIDQvssEVLEGWPDSYKCDYPESYRGtLLKDFHMSELSC 577
Cdd:smart00082   1 NPFICDCELRWLLRWLQA---NEHLQDPVDLRCASPSSLRG-PLLELLHSEFKC 50
LRR_8 pfam13855
Leucine rich repeat;
69-126 1.97e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 48.29  E-value: 1.97e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 929653742   69 SKLRILIISHNTIQYLDISVFKFNQELEYLDLSHNKLVKIS---CHPTVNLKHLDLSFNAF 126
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSpgaFSGLPSLRYLDLSGNRL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 353-474 9.24e-06

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 48.51  E-value: 9.24e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929653742 353 LDFSNNLLTD----TVFENCGHLTELETLILQMNQL--KELSKIAEMTTQMKSLQQLDISQNSVS----YDEKKGDCSWT 422
Cdd:cd00116  170 LNLANNGIGDagirALAEGLKANCNLEVLDLNNNGLtdEGASALAETLASLKSLEVLNLGDNNLTdagaAALASALLSPN 249

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 929653742 423 KSLLSLNMSSNILTDTIFRCL------PPRIKVLDLHSNKIKSIPKQVVKLEALQELN 474
Cdd:cd00116  250 ISLLTLSLSCNDITDDGAKDLaevlaeKESLLELDLRGNKFGEEGAQLLAESLLEPGN 307
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 273-536 2.96e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 47.54  E-value: 2.96e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929653742 273 VWYFSISNVKLQGQLDFRDFDYsgTSLKALSIhqVVSDVFG-FPQSyiyeiFSNMNIKNftvsgtrmvhmlcpskispfl 351
Cdd:PLN00113 430 VYFLDISNNNLQGRINSRKWDM--PSLQMLSL--ARNKFFGgLPDS-----FGSKRLEN--------------------- 479

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929653742 352 hLDFSNNLLTDTVFENCGHLTEletlilqmnqlkelskiaemttqmksLQQLDISQNSVSyDEKKGDCSWTKSLLSLNMS 431
Cdd:PLN00113 480 -LDLSRNQFSGAVPRKLGSLSE--------------------------LMQLKLSENKLS-GEIPDELSSCKKLVSLDLS 531

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929653742 432 SNILTDTIFRCLP--PRIKVLDLHSNKIK-SIPKQVVKLEALQELNVAFNSL-TDLPGCGSFSSLSVLIIDHNSV--SHP 505
Cdd:PLN00113 532 HNQLSGQIPASFSemPVLSQLDLSQNQLSgEIPKNLGNVESLVQVNISHNHLhGSLPSTGAFLAINASAVAGNIDlcGGD 611

                        250       260       270
                 ....*....|....*....|....*....|.
gi 929653742 506 SADFFQSCQKMRsiKAGDNPFQCTCELGEFV 536
Cdd:PLN00113 612 TTSGLPPCKRVR--KTPSWWFYITCTLGAFL 640
LRR_8 pfam13855
Leucine rich repeat;
48-105 3.36e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.13  E-value: 3.36e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 929653742   48 TILNISQNYISELWTSDILSLSKLRILIISHNTIQYLDISVFKFNQELEYLDLSHNKL 105
Cdd:pfam13855   4 RSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
2-152 7.92e-05

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 45.69  E-value: 7.92e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929653742   2 TSIFHFAIIFMLILQIRIQLSEESEFLVDRSKNGLIHVPKDLSQKTTILNISQNYISELwTSDILSLSKLRILIISHNTI 81
Cdd:COG4886   30 LLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLG-LTDLGDLTNLTELDLSGNEE 108

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 929653742  82 qyldisvFKFNQELEYLDLSHNKLVKISCHPT--VNLKHLDLSFNAFDALPicKEFGNMSQLKFLGLSTTHLE 152
Cdd:COG4886  109 -------LSNLTNLESLDLSGNQLTDLPEELAnlTNLKELDLSNNQLTDLP--EPLGNLTNLKSLDLSNNQLT 172
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
344-484 1.00e-04

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 45.84  E-value: 1.00e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929653742 344 PSKISPFLhLDfSNNLLT---------DTVFENCGHLTELETLILQMNQLKELS--KIAEMTTQMKS-LQQLDISQNSVS 411
Cdd:PRK15370 198 PEQITTLI-LD-NNELKSlpenlqgniKTLYANSNQLTSIPATLPDTIQEMELSinRITELPERLPSaLQSLDLFHNKIS 275

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929653742 412 ---------------YDE--KKGDCSWTKSLLSLNMSSNILT----------------DTIFRCLP----PRIKVLDLHS 454
Cdd:PRK15370 276 clpenlpeelrylsvYDNsiRTLPAHLPSGITHLNVQSNSLTalpetlppglktleagENALTSLPaslpPELQVLDVSK 355

                        170       180       190
                 ....*....|....*....|....*....|
gi 929653742 455 NKIKSIPKQVVKleALQELNVAFNSLTDLP 484
Cdd:PRK15370 356 NQITVLPETLPP--TITTLDVSRNALTNLP 383
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
33-130 1.79e-04

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 45.07  E-value: 1.79e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929653742  33 KNGLIHVPKDLSQKTTILNISQNYISELwtSDILSlSKLRILIISHNTIQYLDISVfkfNQELEYLDLSHNKLVKISCHP 112
Cdd:PRK15370 229 SNQLTSIPATLPDTIQEMELSINRITEL--PERLP-SALQSLDLFHNKISCLPENL---PEELRYLSVYDNSIRTLPAHL 302

                         90
                 ....*....|....*...
gi 929653742 113 TVNLKHLDLSFNAFDALP 130
Cdd:PRK15370 303 PSGITHLNVQSNSLTALP 320
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 351-526 2.84e-04

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 42.85  E-value: 2.84e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929653742 351 LHLdFSNNLltdTVFENCGHLTELETLILQMNQLKELskiaEMTTQMKSLQQLDISQNSVSYDEKKGDCSwtkSLLSLNM 430
Cdd:cd21340   29 LYL-YDNKI---TKIENLEFLTNLTHLYLQNNQIEKI----ENLENLVNLKKLYLGGNRISVVEGLENLT---NLEELHI 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929653742 431 SSNiltdtifrCLPPRIKVL-DLHSnkIKSIpkqvvkLEALQELNVAFNSLTDLPGCGSFSSLSVLIIDHNSVSHPS--A 507
Cdd:cd21340   98 ENQ--------RLPPGEKLTfDPRS--LAAL------SNSLRVLNISGNNIDSLEPLAPLRNLEQLDASNNQISDLEelL 161

                        170
                 ....*....|....*....
gi 929653742 508 DFFQSCQKMRSIKAGDNPF 526
Cdd:cd21340  162 DLLSSWPSLRELDLTGNPV 180
LRRCT pfam01463
Leucine rich repeat C-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 553-577 1.44e-03

Leucine rich repeat C-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the C-terminus of tandem leucine rich repeats.


Pssm-ID: 279765  Cd Length: 26  Bit Score: 36.65  E-value: 1.44e-03
                          10        20
                  ....*....|....*....|....*
gi 929653742  553 SYKCDYPESYRGTLLKDFHMSELSC 577
Cdd:pfam01463   1 NARCASPPRLRGQPLLDLLPSDFSC 25
LRR_8 pfam13855
Leucine rich repeat;
445-500 1.56e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.50  E-value: 1.56e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 929653742  445 PRIKVLDLHSNKIKSIPKQV-VKLEALQELNVAFNSLTDLPGcGSFS---SLSVLIIDHN 500
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAfKGLSNLKVLDLSNNLLTTLSP-GAFSglpSLRYLDLSGN 59
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 352-411 2.58e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 40.15  E-value: 2.58e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 929653742 352 HLDFSNNLLTDTvfENCGHLTELETLILQMNQLKELSKIAEMTTQMKSLQQLDISQNSVS 411
Cdd:cd21340  124 VLNISGNNIDSL--EPLAPLRNLEQLDASNNQISDLEELLDLLSSWPSLRELDLTGNPVC 181
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 43-109 3.01e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 39.77  E-value: 3.01e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 929653742  43 LSQKTTILNISQNYISELwtSDILSLSKLRILIISHNTIQYLD--ISVFKFNQELEYLDLSHNKLVKIS 109
Cdd:cd21340  118 LSNSLRVLNISGNNIDSL--EPLAPLRNLEQLDASNNQISDLEelLDLLSSWPSLRELDLTGNPVCKKP 184
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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