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Conserved domains on  [gi|2978255|dbj|BAA25190|]
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myeloid zinc finger protein-2 [Mus musculus]

Protein Classification

zinc finger and SCAN domain-containing protein( domain architecture ID 12210801)

zinc finger and SCAN domain-containing protein (ZSCAN) contains Cys2His2 (C2H2)-type zinc fingers and may act as a transcription factor

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
SCAN smart00431
leucine rich region;
121-232 4.13e-55

leucine rich region;


:

Pssm-ID: 128708 [Multi-domain]  Cd Length: 113  Bit Score: 185.20  E-value: 4.13e-55
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2978255     121 EAARLRFRCFRYEDAIGPQEALAQLRELCHQWLRPEVHSKEQVLELLVLEQFLGALPPEIQAQVQGQWPGSPEEAAALVD 200
Cdd:smart00431   2 EIFRQRFRQFRYQETSGPREALSRLRELCRQWLRPELHTKEQILELLVLEQFLTILPGELQAWVREHHPESGEEAVTLLE 81
                           90       100       110
                   ....*....|....*....|....*....|..
gi 2978255     201 RLRWELDGPRKWVTVQVQGKEVLSEKMEPSSF 232
Cdd:smart00431  82 DLERELDEPGQQVSAHVHGQEVLLEKMVPLGA 113
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
416-807 9.64e-15

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 77.43  E-value: 9.64e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2978255  416 HAPRGRSQSHPRSGTGAMRGGRCDVCGKVFSQRSNLLRHQKIHTGERPFVCGECGR--SFSRSSHLLRHQLTHTEERPFV 493
Cdd:COG5048  14 SVLSSTPKSTLKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCdkSFSRPLELSRHLRTHHNNPSDL 93
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2978255  494 CRDCGQGFVRSARLEEHRR----------------VHTGEQPFRCTECGQSFRQRSNLLQHQRIHGDPPGPAPSILPLAG 557
Cdd:COG5048  94 NSKSLPLSNSKASSSSLSSsssnsndnnllsshslPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPA 173
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2978255  558 VPEPPGPF---------------PCSECCeSFPRRAVLLEHQA-VHTGDKSFGCVECGERFGR---RSVLLQHRRVHSGE 618
Cdd:COG5048 174 NSLSKDPSsnlsllissnvstsiPSSSEN-SPLSSSYSIPSSSsDQNLENSSSSLPLTTNSQLspkSLLSQSPSSLSSSD 252
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2978255  619 RPFACAECGQSFRQRSNLTQHQRIHTGERA-------FACAECGKTFRQRATLTQHL--CVHTGE--KPFACPE--CGQR 685
Cdd:COG5048 253 SSSSASESPRSSLPTASSQSSSPNESDSSSekgfslpIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKL 332
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2978255  686 FSQRLKLTRHQRTHTGEKPYCCGECDLGFTQVSRLTE-------HQRIHTGERPFAC--PECGQSFRQHANLTQHRRIHT 756
Cdd:COG5048 333 FSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLLNNeppqslqQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHL 412
                       410       420       430       440       450
                ....*....|....*....|....*....|....*....|....*....|...
gi 2978255  757 GERPYAC--AECGKAFRQRPTLTQHLRTHrHEKPFACQDCGRRFNQSTKLIQH 807
Cdd:COG5048 413 SFRPYNCknPPCSKSFNRHYNLIPHKKIH-TNHAPLLCSILKSFRRDLDLSNH 464
 
Name Accession Description Interval E-value
SCAN smart00431
leucine rich region;
121-232 4.13e-55

leucine rich region;


Pssm-ID: 128708 [Multi-domain]  Cd Length: 113  Bit Score: 185.20  E-value: 4.13e-55
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2978255     121 EAARLRFRCFRYEDAIGPQEALAQLRELCHQWLRPEVHSKEQVLELLVLEQFLGALPPEIQAQVQGQWPGSPEEAAALVD 200
Cdd:smart00431   2 EIFRQRFRQFRYQETSGPREALSRLRELCRQWLRPELHTKEQILELLVLEQFLTILPGELQAWVREHHPESGEEAVTLLE 81
                           90       100       110
                   ....*....|....*....|....*....|..
gi 2978255     201 RLRWELDGPRKWVTVQVQGKEVLSEKMEPSSF 232
Cdd:smart00431  82 DLERELDEPGQQVSAHVHGQEVLLEKMVPLGA 113
SCAN pfam02023
SCAN domain; The SCAN domain (named after SRE-ZBP, CTfin51, AW-1 and Number 18 cDNA) is found ...
120-208 1.61e-42

SCAN domain; The SCAN domain (named after SRE-ZBP, CTfin51, AW-1 and Number 18 cDNA) is found in several pfam00096 proteins. The domain has been shown to be able to mediate homo- and hetero-oligomerization.


Pssm-ID: 460417 [Multi-domain]  Cd Length: 89  Bit Score: 149.18  E-value: 1.61e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2978255    120 LEAARLRFRCFRYEDAIGPQEALAQLRELCHQWLRPEVHSKEQVLELLVLEQFLGALPPEIQAQVQGQWPGSPEEAAALV 199
Cdd:pfam02023   1 PEASRQRFRQFCYQEAEGPREALSQLRELCHQWLRPEKHTKEQILELLVLEQFLTILPEEIQSWVREHHPESGEEAVALA 80

                  ....*....
gi 2978255    200 DRLRWELDG 208
Cdd:pfam02023  81 EDLLLERGE 89
SCAN cd07936
SCAN oligomerization domain; The SCAN domain (named after SRE-ZBP, CTfin51, AW-1 and Number 18 ...
120-203 3.87e-36

SCAN oligomerization domain; The SCAN domain (named after SRE-ZBP, CTfin51, AW-1 and Number 18 cDNA) is found in several vertebrate proteins that contain C2H2 zinc finger motifs, many of which may be transcription factors playing roles in cell survival and differentiation. This protein-interaction domain is able to mediate homo- and hetero-oligomerization of SCAN-containing proteins. Some SCAN-containing proteins, including those of lower vertebrates, do not contain zinc finger motifs. It has been noted that the SCAN domain resembles a domain-swapped version of the C-terminal domain of the HIV capsid protein. This domain model features elements common to the three general groups of SCAN domains (SCAN-A1, SCAN-A2, and SCAN-B). The SCAND1 protein is truncated at the C-terminus with respect to this model, the SCAND2 protein appears to have a truncated central helix.


Pssm-ID: 153421  Cd Length: 85  Bit Score: 130.84  E-value: 3.87e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2978255  120 LEAARLRFRCFRYEDAIGPQEALAQLRELCHQWLRPEVHSKEQVLELLVLEQFLGALPPEIQAQVQGQWPGSPEEAAALV 199
Cdd:cd07936   1 PETYRQRFRAFQYQEASGPREALQRLRELCRQWLRPEIHTKEQILELLVLEQFLIILPPEVQAWVRERKPESGEEAATLA 80

                ....
gi 2978255  200 DRLR 203
Cdd:cd07936  81 EDLL 84
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
416-807 9.64e-15

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 77.43  E-value: 9.64e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2978255  416 HAPRGRSQSHPRSGTGAMRGGRCDVCGKVFSQRSNLLRHQKIHTGERPFVCGECGR--SFSRSSHLLRHQLTHTEERPFV 493
Cdd:COG5048  14 SVLSSTPKSTLKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCdkSFSRPLELSRHLRTHHNNPSDL 93
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2978255  494 CRDCGQGFVRSARLEEHRR----------------VHTGEQPFRCTECGQSFRQRSNLLQHQRIHGDPPGPAPSILPLAG 557
Cdd:COG5048  94 NSKSLPLSNSKASSSSLSSsssnsndnnllsshslPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPA 173
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2978255  558 VPEPPGPF---------------PCSECCeSFPRRAVLLEHQA-VHTGDKSFGCVECGERFGR---RSVLLQHRRVHSGE 618
Cdd:COG5048 174 NSLSKDPSsnlsllissnvstsiPSSSEN-SPLSSSYSIPSSSsDQNLENSSSSLPLTTNSQLspkSLLSQSPSSLSSSD 252
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2978255  619 RPFACAECGQSFRQRSNLTQHQRIHTGERA-------FACAECGKTFRQRATLTQHL--CVHTGE--KPFACPE--CGQR 685
Cdd:COG5048 253 SSSSASESPRSSLPTASSQSSSPNESDSSSekgfslpIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKL 332
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2978255  686 FSQRLKLTRHQRTHTGEKPYCCGECDLGFTQVSRLTE-------HQRIHTGERPFAC--PECGQSFRQHANLTQHRRIHT 756
Cdd:COG5048 333 FSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLLNNeppqslqQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHL 412
                       410       420       430       440       450
                ....*....|....*....|....*....|....*....|....*....|...
gi 2978255  757 GERPYAC--AECGKAFRQRPTLTQHLRTHrHEKPFACQDCGRRFNQSTKLIQH 807
Cdd:COG5048 413 SFRPYNCknPPCSKSFNRHYNLIPHKKIH-TNHAPLLCSILKSFRRDLDLSNH 464
zf-H2C2_2 pfam13465
Zinc-finger double domain;
747-772 2.77e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.59  E-value: 2.77e-05
                          10        20
                  ....*....|....*....|....*.
gi 2978255    747 NLTQHRRIHTGERPYACAECGKAFRQ 772
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
PHA00733 PHA00733
hypothetical protein
620-669 7.47e-03

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 37.55  E-value: 7.47e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 2978255   620 PFACAECGQSFRQRSNLTQHqrIHTGERAFACAECGKTFRQRATLTQHLC 669
Cdd:PHA00733  73 PYVCPLCLMPFSSSVSLKQH--IRYTEHSKVCPVCGKEFRNTDSTLDHVC 120
 
Name Accession Description Interval E-value
SCAN smart00431
leucine rich region;
121-232 4.13e-55

leucine rich region;


Pssm-ID: 128708 [Multi-domain]  Cd Length: 113  Bit Score: 185.20  E-value: 4.13e-55
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2978255     121 EAARLRFRCFRYEDAIGPQEALAQLRELCHQWLRPEVHSKEQVLELLVLEQFLGALPPEIQAQVQGQWPGSPEEAAALVD 200
Cdd:smart00431   2 EIFRQRFRQFRYQETSGPREALSRLRELCRQWLRPELHTKEQILELLVLEQFLTILPGELQAWVREHHPESGEEAVTLLE 81
                           90       100       110
                   ....*....|....*....|....*....|..
gi 2978255     201 RLRWELDGPRKWVTVQVQGKEVLSEKMEPSSF 232
Cdd:smart00431  82 DLERELDEPGQQVSAHVHGQEVLLEKMVPLGA 113
SCAN pfam02023
SCAN domain; The SCAN domain (named after SRE-ZBP, CTfin51, AW-1 and Number 18 cDNA) is found ...
120-208 1.61e-42

SCAN domain; The SCAN domain (named after SRE-ZBP, CTfin51, AW-1 and Number 18 cDNA) is found in several pfam00096 proteins. The domain has been shown to be able to mediate homo- and hetero-oligomerization.


Pssm-ID: 460417 [Multi-domain]  Cd Length: 89  Bit Score: 149.18  E-value: 1.61e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2978255    120 LEAARLRFRCFRYEDAIGPQEALAQLRELCHQWLRPEVHSKEQVLELLVLEQFLGALPPEIQAQVQGQWPGSPEEAAALV 199
Cdd:pfam02023   1 PEASRQRFRQFCYQEAEGPREALSQLRELCHQWLRPEKHTKEQILELLVLEQFLTILPEEIQSWVREHHPESGEEAVALA 80

                  ....*....
gi 2978255    200 DRLRWELDG 208
Cdd:pfam02023  81 EDLLLERGE 89
SCAN cd07936
SCAN oligomerization domain; The SCAN domain (named after SRE-ZBP, CTfin51, AW-1 and Number 18 ...
120-203 3.87e-36

SCAN oligomerization domain; The SCAN domain (named after SRE-ZBP, CTfin51, AW-1 and Number 18 cDNA) is found in several vertebrate proteins that contain C2H2 zinc finger motifs, many of which may be transcription factors playing roles in cell survival and differentiation. This protein-interaction domain is able to mediate homo- and hetero-oligomerization of SCAN-containing proteins. Some SCAN-containing proteins, including those of lower vertebrates, do not contain zinc finger motifs. It has been noted that the SCAN domain resembles a domain-swapped version of the C-terminal domain of the HIV capsid protein. This domain model features elements common to the three general groups of SCAN domains (SCAN-A1, SCAN-A2, and SCAN-B). The SCAND1 protein is truncated at the C-terminus with respect to this model, the SCAND2 protein appears to have a truncated central helix.


Pssm-ID: 153421  Cd Length: 85  Bit Score: 130.84  E-value: 3.87e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2978255  120 LEAARLRFRCFRYEDAIGPQEALAQLRELCHQWLRPEVHSKEQVLELLVLEQFLGALPPEIQAQVQGQWPGSPEEAAALV 199
Cdd:cd07936   1 PETYRQRFRAFQYQEASGPREALQRLRELCRQWLRPEIHTKEQILELLVLEQFLIILPPEVQAWVRERKPESGEEAATLA 80

                ....
gi 2978255  200 DRLR 203
Cdd:cd07936  81 EDLL 84
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
416-807 9.64e-15

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 77.43  E-value: 9.64e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2978255  416 HAPRGRSQSHPRSGTGAMRGGRCDVCGKVFSQRSNLLRHQKIHTGERPFVCGECGR--SFSRSSHLLRHQLTHTEERPFV 493
Cdd:COG5048  14 SVLSSTPKSTLKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCdkSFSRPLELSRHLRTHHNNPSDL 93
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2978255  494 CRDCGQGFVRSARLEEHRR----------------VHTGEQPFRCTECGQSFRQRSNLLQHQRIHGDPPGPAPSILPLAG 557
Cdd:COG5048  94 NSKSLPLSNSKASSSSLSSsssnsndnnllsshslPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPA 173
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2978255  558 VPEPPGPF---------------PCSECCeSFPRRAVLLEHQA-VHTGDKSFGCVECGERFGR---RSVLLQHRRVHSGE 618
Cdd:COG5048 174 NSLSKDPSsnlsllissnvstsiPSSSEN-SPLSSSYSIPSSSsDQNLENSSSSLPLTTNSQLspkSLLSQSPSSLSSSD 252
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2978255  619 RPFACAECGQSFRQRSNLTQHQRIHTGERA-------FACAECGKTFRQRATLTQHL--CVHTGE--KPFACPE--CGQR 685
Cdd:COG5048 253 SSSSASESPRSSLPTASSQSSSPNESDSSSekgfslpIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKL 332
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 2978255  686 FSQRLKLTRHQRTHTGEKPYCCGECDLGFTQVSRLTE-------HQRIHTGERPFAC--PECGQSFRQHANLTQHRRIHT 756
Cdd:COG5048 333 FSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLLNNeppqslqQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHL 412
                       410       420       430       440       450
                ....*....|....*....|....*....|....*....|....*....|...
gi 2978255  757 GERPYAC--AECGKAFRQRPTLTQHLRTHrHEKPFACQDCGRRFNQSTKLIQH 807
Cdd:COG5048 413 SFRPYNCknPPCSKSFNRHYNLIPHKKIH-TNHAPLLCSILKSFRRDLDLSNH 464
zf-H2C2_2 pfam13465
Zinc-finger double domain;
747-772 2.77e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.59  E-value: 2.77e-05
                          10        20
                  ....*....|....*....|....*.
gi 2978255    747 NLTQHRRIHTGERPYACAECGKAFRQ 772
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
719-744 1.08e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.66  E-value: 1.08e-04
                          10        20
                  ....*....|....*....|....*.
gi 2978255    719 RLTEHQRIHTGERPFACPECGQSFRQ 744
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
464-486 1.58e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 39.21  E-value: 1.58e-04
                          10        20
                  ....*....|....*....|...
gi 2978255    464 FVCGECGRSFSRSSHLLRHQLTH 486
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
635-660 2.37e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 2.37e-04
                          10        20
                  ....*....|....*....|....*.
gi 2978255    635 NLTQHQRIHTGERAFACAECGKTFRQ 660
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
520-542 2.58e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 38.82  E-value: 2.58e-04
                          10        20
                  ....*....|....*....|...
gi 2978255    520 FRCTECGQSFRQRSNLLQHQRIH 542
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
437-458 4.34e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 38.05  E-value: 4.34e-04
                          10        20
                  ....*....|....*....|..
gi 2978255    437 RCDVCGKVFSQRSNLLRHQKIH 458
Cdd:pfam00096   2 KCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
692-716 5.91e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 5.91e-04
                          10        20
                  ....*....|....*....|....*
gi 2978255    692 LTRHQRTHTGEKPYCCGECDLGFTQ 716
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
506-531 7.78e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 7.78e-04
                          10        20
                  ....*....|....*....|....*.
gi 2978255    506 RLEEHRRVHTGEQPFRCTECGQSFRQ 531
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
621-643 1.16e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.89  E-value: 1.16e-03
                          10        20
                  ....*....|....*....|...
gi 2978255    621 FACAECGQSFRQRSNLTQHQRIH 643
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
733-755 1.85e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.12  E-value: 1.85e-03
                          10        20
                  ....*....|....*....|...
gi 2978255    733 FACPECGQSFRQHANLTQHRRIH 755
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
759-812 2.21e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.22  E-value: 2.21e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 2978255  759 RPYACAECGKAFRQRPTLTQHLRTHRHEKPFACQDCGRRFNQST--KLIQHQRVHS 812
Cdd:COG5048  32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRplELSRHLRTHH 87
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
677-699 3.03e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.74  E-value: 3.03e-03
                          10        20
                  ....*....|....*....|...
gi 2978255    677 FACPECGQRFSQRLKLTRHQRTH 699
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
664-688 5.60e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 5.60e-03
                          10        20
                  ....*....|....*....|....*
gi 2978255    664 LTQHLCVHTGEKPFACPECGQRFSQ 688
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
761-783 5.73e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.97  E-value: 5.73e-03
                          10        20
                  ....*....|....*....|...
gi 2978255    761 YACAECGKAFRQRPTLTQHLRTH 783
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
PHA00733 PHA00733
hypothetical protein
620-669 7.47e-03

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 37.55  E-value: 7.47e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 2978255   620 PFACAECGQSFRQRSNLTQHqrIHTGERAFACAECGKTFRQRATLTQHLC 669
Cdd:PHA00733  73 PYVCPLCLMPFSSSVSLKQH--IRYTEHSKVCPVCGKEFRNTDSTLDHVC 120
PHA00733 PHA00733
hypothetical protein
732-780 7.99e-03

hypothetical protein


Pssm-ID: 177301  Cd Length: 128  Bit Score: 37.16  E-value: 7.99e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 2978255   732 PFACPECGQSFRQHANLTQHrrIHTGERPYACAECGKAFRQRPTLTQHL 780
Cdd:PHA00733  73 PYVCPLCLMPFSSSVSLKQH--IRYTEHSKVCPVCGKEFRNTDSTLDHV 119
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
789-811 9.65e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.20  E-value: 9.65e-03
                          10        20
                  ....*....|....*....|...
gi 2978255    789 FACQDCGRRFNQSTKLIQHQRVH 811
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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