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Conserved domains on  [gi|929654416|dbj|BAA32311|]
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KIAA0466 protein [Homo sapiens]

Protein Classification

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List of domain hits

 Name Accession Description Interval E-value
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 687-784 2.60e-11

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


:

Pssm-ID: 462230  Cd Length: 109  Bit Score: 61.71  E-value: 2.60e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654416   687 RTLTLVENKPIQLNCSVKSQTSQNsHFAVLWYVHKPSDADGKLIlktthnsaFEYGTYAEEEGLRARLQFERHVSGGLFS 766
Cdd:pfam07686    4 REVTVALGGSVTLPCTYSSSMSEA-STSVYWYRQPPGKGPTFLI--------AYYSNGSEEGVKKGRFSGRGDPSNGDGS 74

                           90
                   ....*....|....*...
gi 929654416   767 LTVQRAEVSDSGSYYCHV 784
Cdd:pfam07686   75 LTIQNLTLSDSGTYTCAV 92
IgV cd00099
Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin ...
 152-251 7.37e-10

Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin variable domain (IgV). The IgV family contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology, and are components of immunoglobulin (Ig) and T cell receptors. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. Within the variable domain, there are regions of even more variability called the hypervariable or complementarity-determining regions (CDRs) which are responsible for antigen binding. A predominant feature of most Ig domains is the disulfide bridge connecting 2 beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E and, D strands in one sheet and A', G, F, C, C', and C" strands in the other.


:

Pssm-ID: 409355 [Multi-domain]  Cd Length: 111  Bit Score: 57.34  E-value: 7.37e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654416  152 PQTLHRVEQDPLELTCEVaseTIQHSHLSVAWLRQKVGEKPVEVISLSrdfmlhSSSEYAQRQSLGEVRLDKLGRTTFRL 231
Cdd:cd00099     5 PRSLSVQEGESVTLSCEV---SSSFSSTYIYWYRQKPGQGPEFLIYLS------SSKGKTKGGVPGRFSGSRDGTSSFSL 75

                          90       100
                  ....*....|....*....|
gi 929654416  232 TIFHLQPSDQGEFYCEAAEW 251
Cdd:cd00099    76 TISNLQPEDSGTYYCAVSES 95
V-set super family cl46292
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 821-920 8.14e-06

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


The actual alignment was detected with superfamily member pfam07686:

Pssm-ID: 462230  Cd Length: 109  Bit Score: 45.91  E-value: 8.14e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654416   821 QAQGNLSVLETRQVQLECVVLNRTSITSQlMVEWFVWKPNHPERETVARlsrdATFHYGEQAAKNNLKGRlhlESPSPGV 900
Cdd:pfam07686    1 QTPREVTVALGGSVTLPCTYSSSMSEAST-SVYWYRQPPGKGPTFLIAY----YSNGSEEGVKKGRFSGR---GDPSNGD 72

                           90       100
                   ....*....|....*....|
gi 929654416   901 YRLFIQNVAVQDSGTYSCHV 920
Cdd:pfam07686   73 GSLTIQNLTLSDSGTYTCAV 92
Ig super family cl11960
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 32-132 1.51e-05

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


The actual alignment was detected with superfamily member cd00099:

Pssm-ID: 472250 [Multi-domain]  Cd Length: 111  Bit Score: 45.02  E-value: 1.51e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654416   32 RTEGSHITIWCNVSG---------YQGPSEQNFQWSIYLPSSPEREVQIVStmdssfpyaiytqrvrgGKIFIERVQGNS 102
Cdd:cd00099    10 VQEGESVTLSCEVSSsfsstyiywYRQKPGQGPEFLIYLSSSKGKTKGGVP-----------------GRFSGSRDGTSS 72

                          90       100       110
                  ....*....|....*....|....*....|...
gi 929654416  103 TLLHITDLQARDAGEYEC---HTPSTDKQYFGS 132
Cdd:cd00099    73 FSLTISNLQPEDSGTYYCavsESGGTDKLTFGS 105
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 293-389 2.02e-03

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


:

Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 38.26  E-value: 2.02e-03
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654416    293 TVGEPVEFRCILEAQNVPDryfaVSWAFNssliatmgpNAVPVLNSEfahreaRGQLKvakESDSVFVLKIYHLRQEDSG 372
Cdd:smart00410    7 KEGESVTLSCEASGSPPPE----VTWYKQ---------GGKLLAESG------RFSVS---RSGSTSTLTISNVTPEDSG 64

                            90
                    ....*....|....*..
gi 929654416    373 KYNCRVTEREKTVTGEF 389
Cdd:smart00410   65 TYTCAATNSSGSASSGT 81
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 421-514 8.27e-03

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


:

Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 36.71  E-value: 8.27e-03
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654416    421 VILEGEDLRFSCSVRTAGRPQgrfsVIWqlvdrqnRRSNIMWLDRDGTVQpgssyWERSSfggvqmeqvqpNSFSLGIFN 500
Cdd:smart00410    5 TVKEGESVTLSCEASGSPPPE----VTW-------YKQGGKLLAESGRFS-----VSRSG-----------STSTLTISN 57

                            90
                    ....*....|....
gi 929654416    501 SRKEDEGQYECHVT 514
Cdd:smart00410   58 VTPEDSGTYTCAAT 71
 
Name Accession Description Interval E-value
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 687-784 2.60e-11

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 61.71  E-value: 2.60e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654416   687 RTLTLVENKPIQLNCSVKSQTSQNsHFAVLWYVHKPSDADGKLIlktthnsaFEYGTYAEEEGLRARLQFERHVSGGLFS 766
Cdd:pfam07686    4 REVTVALGGSVTLPCTYSSSMSEA-STSVYWYRQPPGKGPTFLI--------AYYSNGSEEGVKKGRFSGRGDPSNGDGS 74

                           90
                   ....*....|....*...
gi 929654416   767 LTVQRAEVSDSGSYYCHV 784
Cdd:pfam07686   75 LTIQNLTLSDSGTYTCAV 92
IgV cd00099
Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin ...
 152-251 7.37e-10

Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin variable domain (IgV). The IgV family contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology, and are components of immunoglobulin (Ig) and T cell receptors. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. Within the variable domain, there are regions of even more variability called the hypervariable or complementarity-determining regions (CDRs) which are responsible for antigen binding. A predominant feature of most Ig domains is the disulfide bridge connecting 2 beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E and, D strands in one sheet and A', G, F, C, C', and C" strands in the other.


Pssm-ID: 409355 [Multi-domain]  Cd Length: 111  Bit Score: 57.34  E-value: 7.37e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654416  152 PQTLHRVEQDPLELTCEVaseTIQHSHLSVAWLRQKVGEKPVEVISLSrdfmlhSSSEYAQRQSLGEVRLDKLGRTTFRL 231
Cdd:cd00099     5 PRSLSVQEGESVTLSCEV---SSSFSSTYIYWYRQKPGQGPEFLIYLS------SSKGKTKGGVPGRFSGSRDGTSSFSL 75

                          90       100
                  ....*....|....*....|
gi 929654416  232 TIFHLQPSDQGEFYCEAAEW 251
Cdd:cd00099    76 TISNLQPEDSGTYYCAVSES 95
IgV_TCR_alpha cd04983
Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) alpha chain and similar ...
 689-811 8.25e-08

Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) alpha chain and similar proteins; The members here are composed of the immunoglobulin (Ig) variable domain of the alpha chain of alpha/beta T-cell antigen receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are composed of alpha and beta, or gamma and delta polypeptide chains with variable (V) and constant (C) regions. This group represents the variable domain of the alpha chain of TCRs and also includes the variable domain of delta chains of TCRs. Alpha/beta TCRs recognize antigen as peptide fragments presented by major histocompatibility complex (MHC) molecules. The variable domain of TCRs is responsible for antigen recognition, and is located at the N-terminus of the receptor. Gamma/delta TCRs recognize intact protein antigens directly without antigen processing and recognize MHC independently of the bound peptide. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409372 [Multi-domain]  Cd Length: 109  Bit Score: 51.50  E-value: 8.25e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654416  689 LTLVENKPIQLNCSVKSQTSQNshfaVLWYVHKPSDADGKLILKTTHNSAFEYGtyaeeeglRARLQFERhvSGGLFSLT 768
Cdd:cd04983     8 LSVQEGENVTLNCNYSTSTFYY----LFWYRQYPGQGPQFLIYISSDSGNKKKG--------RFSATLDK--SRKSSSLH 73

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 929654416  769 VQRAEVSDSGSYYChveewLLSPNYAWYKLaeeVSGR-TEVTVK 811
Cdd:cd04983    74 ISAAQLSDSAVYFC-----ALSESGGTGKL---TFGKgTRLTVE 109
IGv smart00406
Immunoglobulin V-Type;
163-247 1.66e-06

Immunoglobulin V-Type;


Pssm-ID: 214650  Cd Length: 81  Bit Score: 46.99  E-value: 1.66e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654416    163 LELTCEVASETIqhSHLSVAWLRQKVGeKPVEVISLSRDfmlhSSSEYAQRQSLGEVRLDK-LGRTTFRLTIFHLQPSDQ 241
Cdd:smart00406    2 VTLSCKFSGSTF--SSYYVSWVRQPPG-KGLEWLGYIGS----NGSSYYQESYKGRFTISKdTSKNDVSLTISNLRVEDT 74


                    ....*.
gi 929654416    242 GEFYCE 247
Cdd:smart00406   75 GTYYCA 80
IGv smart00406
Immunoglobulin V-Type;
699-782 8.04e-06

Immunoglobulin V-Type;


Pssm-ID: 214650  Cd Length: 81  Bit Score: 45.07  E-value: 8.04e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654416    699 LNCSVKsqTSQNSHFAVLWYVHKPSDAdgkliLKTTHNSAFEYGTYAEEeGLRARLQFERHVSGGLFSLTVQRAEVSDSG 778
Cdd:smart00406    4 LSCKFS--GSTFSSYYVSWVRQPPGKG-----LEWLGYIGSNGSSYYQE-SYKGRFTISKDTSKNDVSLTISNLRVEDTG 75


                    ....
gi 929654416    779 SYYC 782
Cdd:smart00406   76 TYYC 79
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 821-920 8.14e-06

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 45.91  E-value: 8.14e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654416   821 QAQGNLSVLETRQVQLECVVLNRTSITSQlMVEWFVWKPNHPERETVARlsrdATFHYGEQAAKNNLKGRlhlESPSPGV 900
Cdd:pfam07686    1 QTPREVTVALGGSVTLPCTYSSSMSEAST-SVYWYRQPPGKGPTFLIAY----YSNGSEEGVKKGRFSGR---GDPSNGD 72

                           90       100
                   ....*....|....*....|
gi 929654416   901 YRLFIQNVAVQDSGTYSCHV 920
Cdd:pfam07686   73 GSLTIQNLTLSDSGTYTCAV 92
IgV cd00099
Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin ...
 32-132 1.51e-05

Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin variable domain (IgV). The IgV family contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology, and are components of immunoglobulin (Ig) and T cell receptors. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. Within the variable domain, there are regions of even more variability called the hypervariable or complementarity-determining regions (CDRs) which are responsible for antigen binding. A predominant feature of most Ig domains is the disulfide bridge connecting 2 beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E and, D strands in one sheet and A', G, F, C, C', and C" strands in the other.


Pssm-ID: 409355 [Multi-domain]  Cd Length: 111  Bit Score: 45.02  E-value: 1.51e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654416   32 RTEGSHITIWCNVSG---------YQGPSEQNFQWSIYLPSSPEREVQIVStmdssfpyaiytqrvrgGKIFIERVQGNS 102
Cdd:cd00099    10 VQEGESVTLSCEVSSsfsstyiywYRQKPGQGPEFLIYLSSSKGKTKGGVP-----------------GRFSGSRDGTSS 72

                          90       100       110
                  ....*....|....*....|....*....|...
gi 929654416  103 TLLHITDLQARDAGEYEC---HTPSTDKQYFGS 132
Cdd:cd00099    73 FSLTISNLQPEDSGTYYCavsESGGTDKLTFGS 105
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 34-141 3.78e-05

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 43.99  E-value: 3.78e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654416    34 EGSHITIWCNVSGYQGPSEQNFQWSIYLPSSPEREVQIVSTmdSSFPYAIYTQRVRGGKIFIErvqgNSTLLHITDLQAR 113
Cdd:pfam07686   10 LGGSVTLPCTYSSSMSEASTSVYWYRQPPGKGPTFLIAYYS--NGSEEGVKKGRFSGRGDPSN----GDGSLTIQNLTLS 83

                           90       100
                   ....*....|....*....|....*...
gi 929654416   114 DAGEYECHTPSTDKQYFGSysaKMNLVV 141
Cdd:pfam07686   84 DSGTYTCAVIPSGEGVFGK---GTRLTV 108
IgV_CRIg cd16089
Immunoglobulin variable (IgV)-like domain in complement receptor of the immunoglobulin ...
 848-920 6.47e-05

Immunoglobulin variable (IgV)-like domain in complement receptor of the immunoglobulin superfamily (CRIg); The members here are composed of the immunoglobulin variable (IgV) region of the complement receptor of the immunoglobulin superfamily (CRIg). The N-terminal domain of CRIg (also known as Z39Ig and V-set and Ig domain-containing 4 (VSIG4) belongs to the IgV family of immunoglobulin-like domains while the C-terminal domain of CRIg belongs to the IgC family of immunoglobulin-like domains. Like all members of this family, the CRIg domain contains two beta-sheets: one composed of strands A', G, F, C, C' and C", and the other of strands B, E and D. The complement system is an important part of the innate immune system and is required for removal of pathogens from the bloodstream. After exposure to pathogens, the third component of the complement system, C3, is cleaved to C3b which, after recruitment of factor B, initiates formation of the alternative pathway convertases. CRIg, a complement receptor expressed on macrophages, binds to C3b and iC3b mediating phagocytosis of the particles. It is also a potent inhibitor of the alternative pathway convertases and a negative regulator of T cell activation. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, such as, T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, such as, butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond.


Pssm-ID: 409510  Cd Length: 117  Bit Score: 43.67  E-value: 6.47e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 929654416  848 SQLMVEWFVWKPNHPeretVARLSRDATfhyGEQAAKNNLKGRLHLESPSPGVYRLFIQNVAVQDSGTYSCHV 920
Cdd:cd16089    30 TQVLVKWLVQRDSDP----VTIFLRDSS---GDHIQQAKYRGRLEVSKDTPGDVSLQLDTLEMDDRGHYTCQV 95
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 152-246 1.50e-04

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 42.45  E-value: 1.50e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654416   152 PQTLHRVEQDPLELTCEVASETIQHsHLSVAWLRQKVGEKPVEVISLSrdfmlHSSSEYAQRQSLGEVRLDKlGRTTFRL 231
Cdd:pfam07686    3 PREVTVALGGSVTLPCTYSSSMSEA-STSVYWYRQPPGKGPTFLIAYY-----SNGSEEGVKKGRFSGRGDP-SNGDGSL 75

                           90
                   ....*....|....*
gi 929654416   232 TIFHLQPSDQGEFYC 246
Cdd:pfam07686   76 TIQNLTLSDSGTYTC 90
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 293-389 2.02e-03

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 38.26  E-value: 2.02e-03
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654416    293 TVGEPVEFRCILEAQNVPDryfaVSWAFNssliatmgpNAVPVLNSEfahreaRGQLKvakESDSVFVLKIYHLRQEDSG 372
Cdd:smart00410    7 KEGESVTLSCEASGSPPPE----VTWYKQ---------GGKLLAESG------RFSVS---RSGSTSTLTISNVTPEDSG 64

                            90
                    ....*....|....*..
gi 929654416    373 KYNCRVTEREKTVTGEF 389
Cdd:smart00410   65 TYTCAATNSSGSASSGT 81
IgV_CD2_like_N cd05775
N-terminal immunoglobulin (Ig)-like domain of T-cell surface antigen CD2, and similar domains; ...
 294-386 2.25e-03

N-terminal immunoglobulin (Ig)-like domain of T-cell surface antigen CD2, and similar domains; The members here are composed of the N-terminal immunoglobulin (Ig)-like domain (or domain 1) of T-cell surface antigen Clusters of Differentiation (CD) 2 and similar proteins. CD2 is a T-cell specific surface glycoprotein and is critically important for mediating adhesion between T cells and antigen-presenting cells or between cytolytic T cells and target cells. CD2 is located on chromosome 1 at 1p13 in humans and on chromosome 3 in mice. CD2 contains an extracellular domain with two or Ig-like domains, a single transmembrane segment, and a cytoplasmic region rich in proline and basic residues.


Pssm-ID: 409431  Cd Length: 98  Bit Score: 38.48  E-value: 2.25e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654416  294 VGEPVEFRcileAQNVPDRYFAVSWAFNSSLIATMGPNAVPvlnSEFAHREARGQLKvaKESDSvfvLKIYHLRQEDSGK 373
Cdd:cd05775     9 LGGNVTLT----ISSLQDDIDEIKWKKTKDKIVEWENNIGP---TYFGSFKDRVLLD--KESGS---LTIKNLTKEDSGT 76

                          90
                  ....*....|...
gi 929654416  374 YNCRVTEREKTVT 386
Cdd:cd05775    77 YELEITSTNGKVL 89
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 421-514 8.27e-03

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 36.71  E-value: 8.27e-03
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654416    421 VILEGEDLRFSCSVRTAGRPQgrfsVIWqlvdrqnRRSNIMWLDRDGTVQpgssyWERSSfggvqmeqvqpNSFSLGIFN 500
Cdd:smart00410    5 TVKEGESVTLSCEASGSPPPE----VTW-------YKQGGKLLAESGRFS-----VSRSG-----------STSTLTISN 57

                            90
                    ....*....|....
gi 929654416    501 SRKEDEGQYECHVT 514
Cdd:smart00410   58 VTPEDSGTYTCAAT 71
 
Name Accession Description Interval E-value
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 687-784 2.60e-11

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 61.71  E-value: 2.60e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654416   687 RTLTLVENKPIQLNCSVKSQTSQNsHFAVLWYVHKPSDADGKLIlktthnsaFEYGTYAEEEGLRARLQFERHVSGGLFS 766
Cdd:pfam07686    4 REVTVALGGSVTLPCTYSSSMSEA-STSVYWYRQPPGKGPTFLI--------AYYSNGSEEGVKKGRFSGRGDPSNGDGS 74

                           90
                   ....*....|....*...
gi 929654416   767 LTVQRAEVSDSGSYYCHV 784
Cdd:pfam07686   75 LTIQNLTLSDSGTYTCAV 92
IgV cd00099
Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin ...
 152-251 7.37e-10

Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin variable domain (IgV). The IgV family contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology, and are components of immunoglobulin (Ig) and T cell receptors. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. Within the variable domain, there are regions of even more variability called the hypervariable or complementarity-determining regions (CDRs) which are responsible for antigen binding. A predominant feature of most Ig domains is the disulfide bridge connecting 2 beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E and, D strands in one sheet and A', G, F, C, C', and C" strands in the other.


Pssm-ID: 409355 [Multi-domain]  Cd Length: 111  Bit Score: 57.34  E-value: 7.37e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654416  152 PQTLHRVEQDPLELTCEVaseTIQHSHLSVAWLRQKVGEKPVEVISLSrdfmlhSSSEYAQRQSLGEVRLDKLGRTTFRL 231
Cdd:cd00099     5 PRSLSVQEGESVTLSCEV---SSSFSSTYIYWYRQKPGQGPEFLIYLS------SSKGKTKGGVPGRFSGSRDGTSSFSL 75

                          90       100
                  ....*....|....*....|
gi 929654416  232 TIFHLQPSDQGEFYCEAAEW 251
Cdd:cd00099    76 TISNLQPEDSGTYYCAVSES 95
IgV_TCR_alpha cd04983
Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) alpha chain and similar ...
 689-811 8.25e-08

Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) alpha chain and similar proteins; The members here are composed of the immunoglobulin (Ig) variable domain of the alpha chain of alpha/beta T-cell antigen receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are composed of alpha and beta, or gamma and delta polypeptide chains with variable (V) and constant (C) regions. This group represents the variable domain of the alpha chain of TCRs and also includes the variable domain of delta chains of TCRs. Alpha/beta TCRs recognize antigen as peptide fragments presented by major histocompatibility complex (MHC) molecules. The variable domain of TCRs is responsible for antigen recognition, and is located at the N-terminus of the receptor. Gamma/delta TCRs recognize intact protein antigens directly without antigen processing and recognize MHC independently of the bound peptide. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409372 [Multi-domain]  Cd Length: 109  Bit Score: 51.50  E-value: 8.25e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654416  689 LTLVENKPIQLNCSVKSQTSQNshfaVLWYVHKPSDADGKLILKTTHNSAFEYGtyaeeeglRARLQFERhvSGGLFSLT 768
Cdd:cd04983     8 LSVQEGENVTLNCNYSTSTFYY----LFWYRQYPGQGPQFLIYISSDSGNKKKG--------RFSATLDK--SRKSSSLH 73

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 929654416  769 VQRAEVSDSGSYYChveewLLSPNYAWYKLaeeVSGR-TEVTVK 811
Cdd:cd04983    74 ISAAQLSDSAVYFC-----ALSESGGTGKL---TFGKgTRLTVE 109
IgV cd00099
Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin ...
 685-810 3.52e-07

Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin variable domain (IgV). The IgV family contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology, and are components of immunoglobulin (Ig) and T cell receptors. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. Within the variable domain, there are regions of even more variability called the hypervariable or complementarity-determining regions (CDRs) which are responsible for antigen binding. A predominant feature of most Ig domains is the disulfide bridge connecting 2 beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E and, D strands in one sheet and A', G, F, C, C', and C" strands in the other.


Pssm-ID: 409355 [Multi-domain]  Cd Length: 111  Bit Score: 50.03  E-value: 3.52e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654416  685 SKRTLTLVENKPIQLNCSVksqTSQNSHFAVLWYVHKPSDADgKLILKTTHNSAFEygtyaeEEGLRARLQFERHvSGGL 764
Cdd:cd00099     4 SPRSLSVQEGESVTLSCEV---SSSFSSTYIYWYRQKPGQGP-EFLIYLSSSKGKT------KGGVPGRFSGSRD-GTSS 72

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 929654416  765 FSLTVQRAEVSDSGSYYChveewLLSPNYAWYKLaeeVSGR-TEVTV 810
Cdd:cd00099    73 FSLTISNLQPEDSGTYYC-----AVSESGGTDKL---TFGSgTRLTV 111
IGv smart00406
Immunoglobulin V-Type;
163-247 1.66e-06

Immunoglobulin V-Type;


Pssm-ID: 214650  Cd Length: 81  Bit Score: 46.99  E-value: 1.66e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654416    163 LELTCEVASETIqhSHLSVAWLRQKVGeKPVEVISLSRDfmlhSSSEYAQRQSLGEVRLDK-LGRTTFRLTIFHLQPSDQ 241
Cdd:smart00406    2 VTLSCKFSGSTF--SSYYVSWVRQPPG-KGLEWLGYIGS----NGSSYYQESYKGRFTISKdTSKNDVSLTISNLRVEDT 74


                    ....*.
gi 929654416    242 GEFYCE 247
Cdd:smart00406   75 GTYYCA 80
IGv smart00406
Immunoglobulin V-Type;
699-782 8.04e-06

Immunoglobulin V-Type;


Pssm-ID: 214650  Cd Length: 81  Bit Score: 45.07  E-value: 8.04e-06
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654416    699 LNCSVKsqTSQNSHFAVLWYVHKPSDAdgkliLKTTHNSAFEYGTYAEEeGLRARLQFERHVSGGLFSLTVQRAEVSDSG 778
Cdd:smart00406    4 LSCKFS--GSTFSSYYVSWVRQPPGKG-----LEWLGYIGSNGSSYYQE-SYKGRFTISKDTSKNDVSLTISNLRVEDTG 75


                    ....
gi 929654416    779 SYYC 782
Cdd:smart00406   76 TYYC 79
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 821-920 8.14e-06

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 45.91  E-value: 8.14e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654416   821 QAQGNLSVLETRQVQLECVVLNRTSITSQlMVEWFVWKPNHPERETVARlsrdATFHYGEQAAKNNLKGRlhlESPSPGV 900
Cdd:pfam07686    1 QTPREVTVALGGSVTLPCTYSSSMSEAST-SVYWYRQPPGKGPTFLIAY----YSNGSEEGVKKGRFSGR---GDPSNGD 72

                           90       100
                   ....*....|....*....|
gi 929654416   901 YRLFIQNVAVQDSGTYSCHV 920
Cdd:pfam07686   73 GSLTIQNLTLSDSGTYTCAV 92
IgV cd00099
Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin ...
 32-132 1.51e-05

Immunoglobulin variable domain (IgV); The members here are composed of the immunoglobulin variable domain (IgV). The IgV family contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology, and are components of immunoglobulin (Ig) and T cell receptors. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. Within the variable domain, there are regions of even more variability called the hypervariable or complementarity-determining regions (CDRs) which are responsible for antigen binding. A predominant feature of most Ig domains is the disulfide bridge connecting 2 beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E and, D strands in one sheet and A', G, F, C, C', and C" strands in the other.


Pssm-ID: 409355 [Multi-domain]  Cd Length: 111  Bit Score: 45.02  E-value: 1.51e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654416   32 RTEGSHITIWCNVSG---------YQGPSEQNFQWSIYLPSSPEREVQIVStmdssfpyaiytqrvrgGKIFIERVQGNS 102
Cdd:cd00099    10 VQEGESVTLSCEVSSsfsstyiywYRQKPGQGPEFLIYLSSSKGKTKGGVP-----------------GRFSGSRDGTSS 72

                          90       100       110
                  ....*....|....*....|....*....|...
gi 929654416  103 TLLHITDLQARDAGEYEC---HTPSTDKQYFGS 132
Cdd:cd00099    73 FSLTISNLQPEDSGTYYCavsESGGTDKLTFGS 105
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 34-141 3.78e-05

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 43.99  E-value: 3.78e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654416    34 EGSHITIWCNVSGYQGPSEQNFQWSIYLPSSPEREVQIVSTmdSSFPYAIYTQRVRGGKIFIErvqgNSTLLHITDLQAR 113
Cdd:pfam07686   10 LGGSVTLPCTYSSSMSEASTSVYWYRQPPGKGPTFLIAYYS--NGSEEGVKKGRFSGRGDPSN----GDGSLTIQNLTLS 83

                           90       100
                   ....*....|....*....|....*...
gi 929654416   114 DAGEYECHTPSTDKQYFGSysaKMNLVV 141
Cdd:pfam07686   84 DSGTYTCAVIPSGEGVFGK---GTRLTV 108
IgV_CRIg cd16089
Immunoglobulin variable (IgV)-like domain in complement receptor of the immunoglobulin ...
 848-920 6.47e-05

Immunoglobulin variable (IgV)-like domain in complement receptor of the immunoglobulin superfamily (CRIg); The members here are composed of the immunoglobulin variable (IgV) region of the complement receptor of the immunoglobulin superfamily (CRIg). The N-terminal domain of CRIg (also known as Z39Ig and V-set and Ig domain-containing 4 (VSIG4) belongs to the IgV family of immunoglobulin-like domains while the C-terminal domain of CRIg belongs to the IgC family of immunoglobulin-like domains. Like all members of this family, the CRIg domain contains two beta-sheets: one composed of strands A', G, F, C, C' and C", and the other of strands B, E and D. The complement system is an important part of the innate immune system and is required for removal of pathogens from the bloodstream. After exposure to pathogens, the third component of the complement system, C3, is cleaved to C3b which, after recruitment of factor B, initiates formation of the alternative pathway convertases. CRIg, a complement receptor expressed on macrophages, binds to C3b and iC3b mediating phagocytosis of the particles. It is also a potent inhibitor of the alternative pathway convertases and a negative regulator of T cell activation. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, such as, T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, such as, butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond.


Pssm-ID: 409510  Cd Length: 117  Bit Score: 43.67  E-value: 6.47e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 929654416  848 SQLMVEWFVWKPNHPeretVARLSRDATfhyGEQAAKNNLKGRLHLESPSPGVYRLFIQNVAVQDSGTYSCHV 920
Cdd:cd16089    30 TQVLVKWLVQRDSDP----VTIFLRDSS---GDHIQQAKYRGRLEVSKDTPGDVSLQLDTLEMDDRGHYTCQV 95
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 152-248 1.19e-04

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 41.72  E-value: 1.19e-04
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654416    152 PQTLHRVEQDPLELTCEVASEtiqhSHLSVAWLRQKVgekpvEVISLSRDFMLHSSSeyaqrqslgevrldklgrTTFRL 231
Cdd:smart00410    1 PPSVTVKEGESVTLSCEASGS----PPPEVTWYKQGG-----KLLAESGRFSVSRSG------------------STSTL 53

                            90
                    ....*....|....*..
gi 929654416    232 TIFHLQPSDQGEFYCEA 248
Cdd:smart00410   54 TISNVTPEDSGTYTCAA 70
IgV_TCR_beta cd05899
Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) beta chain; The members here ...
 682-782 1.20e-04

Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) beta chain; The members here are composed of the immunoglobulin (Ig) variable domain of the beta chain of alpha/beta T-cell antigen receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are composed of alpha and beta, or gamma and delta, polypeptide chains with variable (V) and constant (C) regions. This group includes the variable domain of the alpha chain of alpha/beta TCRs. Alpha/beta TCRs recognize antigen as peptide fragments presented by major histocompatibility complex (MHC) molecules. The variable domain of TCRs is responsible for antigen recognition, and is located at the N-terminus of the receptor. Gamma/delta TCRs recognize intact protein antigens directly without antigen processing and recognize MHC independently of the bound peptide. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409480  Cd Length: 110  Bit Score: 42.65  E-value: 1.20e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654416  682 VSKSKRTLTLVENKPIQLNCSVKSQtsqnsHFAVLWYVHKPsdadGK-LILKTTHNSAFEYgtyaEEEGL-RARLQFERH 759
Cdd:cd05899     1 VTQSPRYLIKRRGQSVTLRCSQKSG-----HDNMYWYRQDP----GKgLQLLFYSYGGGLN----EEGDLpGDRFSASRP 67

                          90       100
                  ....*....|....*....|...
gi 929654416  760 vSGGLFSLTVQRAEVSDSGSYYC 782
Cdd:cd05899    68 -SLTRSSLTIKSAEPEDSAVYLC 89
V-set pfam07686
Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 ...
 152-246 1.50e-04

Immunoglobulin V-set domain; This domain is found in antibodies as well as neural protein P0 and CTL4 amongst others.


Pssm-ID: 462230  Cd Length: 109  Bit Score: 42.45  E-value: 1.50e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654416   152 PQTLHRVEQDPLELTCEVASETIQHsHLSVAWLRQKVGEKPVEVISLSrdfmlHSSSEYAQRQSLGEVRLDKlGRTTFRL 231
Cdd:pfam07686    3 PREVTVALGGSVTLPCTYSSSMSEA-STSVYWYRQPPGKGPTFLIAYY-----SNGSEEGVKKGRFSGRGDP-SNGDGSL 75

                           90
                   ....*....|....*
gi 929654416   232 TIFHLQPSDQGEFYC 246
Cdd:pfam07686   76 TIQNLTLSDSGTYTC 90
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 22-120 1.78e-04

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 41.01  E-value: 1.78e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654416    22 QVTVQEGPLYRTEGSHITIWCNVSGYQGPSeqnFQWsiYLPSSPEREVQIVSTMDSsfpyaiytqrvrggkifiervqGN 101
Cdd:pfam13927    3 VITVSPSSVTVREGETVTLTCEATGSPPPT---ITW--YKNGEPISSGSTRSRSLS----------------------GS 55

                           90
                   ....*....|....*....
gi 929654416   102 STLLHITDLQARDAGEYEC 120
Cdd:pfam13927   56 NSTLTISNVTRSDAGTYTC 74
IgV_TCR_gamma cd04982
Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) gamma chain; The members here ...
 693-798 1.85e-04

Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) gamma chain; The members here are composed of the immunoglobulin (Ig) variable (V) domain of the gamma chain of gamma/delta T-cell receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are heterodimers consisting of alpha and beta chains or gamma and delta chains. Each chain contains a variable (V) and a constant (C) region. The majority of T cells contain alpha/beta TCRs, but a small subset contain gamma/delta TCRs. Alpha/beta TCRs recognize antigens as peptide fragments presented by major histocompatibility complex (MHC) molecules. Gamma/delta TCRs recognize intact protein antigens directly without antigen processing and recognize MHC independently of the bound peptide. Gamma/delta T cells can also be stimulated by non-peptide antigens such as small phosphate- or amine-containing compounds. The variable domain of gamma/delta TCRs is responsible for antigen recognition and is located at the N-terminus of the receptor. Members of this group contain the standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409371  Cd Length: 117  Bit Score: 42.35  E-value: 1.85e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654416  693 ENKPIQLNCSVKSQTsqNSHFAVLWYVHKPSDADGKLI-LKTTHNSAFEYGTYAEEegLRARLQFERHVSgglfSLTVQR 771
Cdd:cd04982    12 ESKSVTISCKVSGID--FSTTYIHWYRQKPGQALERLLyVSSTSAVRKDSGKTKNK--FEARKDVGKSTS----TLTITN 83

                          90       100
                  ....*....|....*....|....*..
gi 929654416  772 AEVSDSGSYYCHVeeWLLSPNYaWYKL 798
Cdd:cd04982    84 LEKEDSATYYCAY--WESGSGY-YIKV 107
IgV_H_TCR_mu cd16095
T-cell receptor Mu, Heavy chain, variable (V) domain; The members here are composed of the ...
 28-132 8.09e-04

T-cell receptor Mu, Heavy chain, variable (V) domain; The members here are composed of the immunoglobulin (Ig) heavy chain (H), variable (V) domain of the T-cell receptor Mu. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. In Ig, each chain is composed of one variable domain (IgV) and one or more constant domains (IgC); these names reflect the fact that the variability in sequences is higher in the variable domain than in the constant domain. There are five types of heavy chains (alpha, gamma, delta, epsilon, and mu), which determines the type of immunoglobulin formed: IgA, IgG, IgD, IgE, and IgM, respectively. In higher vertebrates, there are two types of light chain, designated kappa and lambda, which can associate with any of the heavy chains. This family includes alpha, gamma, delta, epsilon, and mu heavy chains. Members of this group contain standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409514  Cd Length: 115  Bit Score: 40.24  E-value: 8.09e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654416   28 GPLYRTeGSHITIWCNVSGYQGPSEQnFQWSIYLPS-SPerevQIVSTMDSSFpyaiytQRVRGGKIFIERVQGNSTL-L 105
Cdd:cd16095     9 GGSHPA-GKTLSLKCQTSGFQFNTSQ-LSWYLWVPGhAP----LWLTSLDHIS------TKVSEDRITSSREDTNSQIfL 76

                          90       100       110
                  ....*....|....*....|....*....|..
gi 929654416  106 HITDLQARDAGEYEC-----HTPSTDKQYFGS 132
Cdd:cd16095    77 QIKGLGLRDSGQYHCarrvgYGDDTDKLIFGP 108
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 687-810 1.43e-03

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 39.03  E-value: 1.43e-03
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654416    687 RTLTLVENKPIQLNCSVksqtSQNSHFAVLWYVHKPsdadgKLILKTTHnsafeygtyaeeeglrarlqFERHVSGGLFS 766
Cdd:smart00410    2 PSVTVKEGESVTLSCEA----SGSPPPEVTWYKQGG-----KLLAESGR--------------------FSVSRSGSTST 52

                            90       100       110       120
                    ....*....|....*....|....*....|....*....|....
gi 929654416    767 LTVQRAEVSDSGSYYCHVEewllspNYAWyklaeEVSGRTEVTV 810
Cdd:smart00410   53 LTISNVTPEDSGTYTCAAT------NSSG-----SASSGTTLTV 85
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 293-389 2.02e-03

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 38.26  E-value: 2.02e-03
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654416    293 TVGEPVEFRCILEAQNVPDryfaVSWAFNssliatmgpNAVPVLNSEfahreaRGQLKvakESDSVFVLKIYHLRQEDSG 372
Cdd:smart00410    7 KEGESVTLSCEASGSPPPE----VTWYKQ---------GGKLLAESG------RFSVS---RSGSTSTLTISNVTPEDSG 64

                            90
                    ....*....|....*..
gi 929654416    373 KYNCRVTEREKTVTGEF 389
Cdd:smart00410   65 TYTCAATNSSGSASSGT 81
IgV_CD2_like_N cd05775
N-terminal immunoglobulin (Ig)-like domain of T-cell surface antigen CD2, and similar domains; ...
 294-386 2.25e-03

N-terminal immunoglobulin (Ig)-like domain of T-cell surface antigen CD2, and similar domains; The members here are composed of the N-terminal immunoglobulin (Ig)-like domain (or domain 1) of T-cell surface antigen Clusters of Differentiation (CD) 2 and similar proteins. CD2 is a T-cell specific surface glycoprotein and is critically important for mediating adhesion between T cells and antigen-presenting cells or between cytolytic T cells and target cells. CD2 is located on chromosome 1 at 1p13 in humans and on chromosome 3 in mice. CD2 contains an extracellular domain with two or Ig-like domains, a single transmembrane segment, and a cytoplasmic region rich in proline and basic residues.


Pssm-ID: 409431  Cd Length: 98  Bit Score: 38.48  E-value: 2.25e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654416  294 VGEPVEFRcileAQNVPDRYFAVSWAFNSSLIATMGPNAVPvlnSEFAHREARGQLKvaKESDSvfvLKIYHLRQEDSGK 373
Cdd:cd05775     9 LGGNVTLT----ISSLQDDIDEIKWKKTKDKIVEWENNIGP---TYFGSFKDRVLLD--KESGS---LTIKNLTKEDSGT 76

                          90
                  ....*....|...
gi 929654416  374 YNCRVTEREKTVT 386
Cdd:cd05775    77 YELEITSTNGKVL 89
IgV_CAR_like cd20960
Immunoglobulin Variable (V) domain of the Coxsackievirus and Adenovirus Receptor (CAR), and ...
 850-920 3.98e-03

Immunoglobulin Variable (V) domain of the Coxsackievirus and Adenovirus Receptor (CAR), and similar proteins; The members here are composed of the Variable (V) domain of the Coxsackievirus and Adenovirus Receptor (CAR), and similar proteins. CAR, which is encoded by human CXADR gene, is a cell adhesion molecule of the Immunoglobulin (Ig) superfamily. The CAR acts as a type I membrane receptor for group B1-B6 coxsackie viruses and subgroup C adenoviruses. For instance, adenovirus interacts with the coxsackievirus and adenovirus receptor to enter epithelial airway cells. The CAR is also shown to be involved in physiological processes such as neuronal and heart development, epithelial tight junction integrity, and tumor suppression. The CAR is a component of the epithelial apical junction complex that may function as a homophilic cell adhesion molecule and is essential for tight junction integrity. The CAR is also involved in transepithelial migration of leukocytes through adhesive interactions with JAML a transmembrane protein of the plasma membrane of leukocytes. The interaction between both receptors also mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. The CAR is composed of one V-set and one C2-set Ig module, a single transmembrane helix, and an intracellular domain. This group belongs to the V-set of IgSF domains, having A, B, E and D strands in one beta-sheet and A', G, F, C, C' and C" in the other


Pssm-ID: 409552  Cd Length: 114  Bit Score: 38.20  E-value: 3.98e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 929654416  850 LMVEWFVWKPNHPEReTVARLSRDATF-HYGEqaaknNLKGRLHLESP-SPGVYRLFIQNVAVQDSGTYSCHV 920
Cdd:cd20960    34 LDIEWLLLPSDKVEK-VVITYSGDRVYnHYYP-----ALKGRVAFTSNdLSGDASLNISNLKLSDTGTYQCKV 100
IgV_TCR_gamma cd04982
Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) gamma chain; The members here ...
 157-251 4.58e-03

Immunoglobulin (Ig) variable (V) domain of T-cell receptor (TCR) gamma chain; The members here are composed of the immunoglobulin (Ig) variable (V) domain of the gamma chain of gamma/delta T-cell receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are heterodimers consisting of alpha and beta chains or gamma and delta chains. Each chain contains a variable (V) and a constant (C) region. The majority of T cells contain alpha/beta TCRs, but a small subset contain gamma/delta TCRs. Alpha/beta TCRs recognize antigens as peptide fragments presented by major histocompatibility complex (MHC) molecules. Gamma/delta TCRs recognize intact protein antigens directly without antigen processing and recognize MHC independently of the bound peptide. Gamma/delta T cells can also be stimulated by non-peptide antigens such as small phosphate- or amine-containing compounds. The variable domain of gamma/delta TCRs is responsible for antigen recognition and is located at the N-terminus of the receptor. Members of this group contain the standard Ig superfamily V-set AGFCC'C"/DEB domain topology.


Pssm-ID: 409371  Cd Length: 117  Bit Score: 38.11  E-value: 4.58e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654416  157 RVEQDPLELTCEVASETIQHShlSVAWLRQKVGEKPVEVIS-LSRDFMLHSSSEYAQRQslgEVRLDKlGRTTFRLTIFH 235
Cdd:cd04982    10 REESKSVTISCKVSGIDFSTT--YIHWYRQKPGQALERLLYvSSTSAVRKDSGKTKNKF---EARKDV-GKSTSTLTITN 83

                          90
                  ....*....|....*.
gi 929654416  236 LQPSDQGEFYCeaAEW 251
Cdd:cd04982    84 LEKEDSATYYC--AYW 97
IgV_L_kappa cd04980
Immunoglobulin (Ig) light chain, kappa type, variable (V) domain; The members here are ...
 146-252 8.03e-03

Immunoglobulin (Ig) light chain, kappa type, variable (V) domain; The members here are composed of the immunoglobulin (Ig) light chain, kappa type, variable (V) domain. This group contains the standard Ig superfamily V-set AGFCC'C"/DEB domain topology. The basic structure of Ig molecules is a tetramer of two light chains and two heavy chains linked by disulfide bonds. There are two types of light chains: kappa and lambda, each composed of a constant domain (CL) and a variable domain (VL). There are five types of heavy chains (alpha, gamma, delta, epsilon, and mu), which determines the type of immunoglobulin formed: IgA, IgG, IgD, IgE, and IgM, respectively. In higher vertebrates, there are two types of light chain, designated kappa and lambda, which seem to be functionally identical, and can associate with any of the heavy chains.


Pssm-ID: 409369  Cd Length: 106  Bit Score: 37.37  E-value: 8.03e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654416  146 LQTTAMPQTLHRVEQDPLELTCEvASETIQHSHLsvAWLRQKVGEKPVEVISLSrdfmlhssseyAQRQSLGEVRLDKLG 225
Cdd:cd04980     1 IVMTQSPASLSVSPGERVTISCK-ASQSISSNYL--AWYQQKPGQAPKLLIYYA-----------STLHSGVPSRFSGSG 66

                          90       100
                  ....*....|....*....|....*...
gi 929654416  226 -RTTFRLTIFHLQPSDQGEFYCEAAEWI 252
Cdd:cd04980    67 sGTDFTLTISSVEPEDAAVYYCQQGYTF 94
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 421-514 8.27e-03

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 36.71  E-value: 8.27e-03
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654416    421 VILEGEDLRFSCSVRTAGRPQgrfsVIWqlvdrqnRRSNIMWLDRDGTVQpgssyWERSSfggvqmeqvqpNSFSLGIFN 500
Cdd:smart00410    5 TVKEGESVTLSCEASGSPPPE----VTW-------YKQGGKLLAESGRFS-----VSRSG-----------STSTLTISN 57

                            90
                    ....*....|....
gi 929654416    501 SRKEDEGQYECHVT 514
Cdd:smart00410   58 VTPEDSGTYTCAAT 71
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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