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Conserved domains on  [gi|929654192|dbj|BAA76792|]
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KIAA0948 protein [Homo sapiens]

Protein Classification

FAST kinase domain-containing protein( domain architecture ID 10535844)

FAST kinase domain-containing protein similar to human Fas-activated serine/threonine (FAST) kinase that phosphorylates the splicing regulator TIA1, thereby promoting the inclusion of FAS exon 6, which leads to an mRNA encoding a pro-apoptotic form of the receptor

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TBRG4-like_N cd23739
transforming growth factor beta (TGFbeta) regulator 4 (TBRG4) and similar proteins; predicted ...
 96-271 1.66e-61

transforming growth factor beta (TGFbeta) regulator 4 (TBRG4) and similar proteins; predicted alpha-helical domain N-terminal to FAST kinase-like protein, subdomain 1 (FAST_1); TBRG4 also called cell cycle progression restoration protein 2 or Fas-activated serine-threonine (FAST) kinase domain-containing protein 4, is a regulator of TGFbeta and is implicated in numerous types of cancer. It serves a role in the tumorigenesis of lung cancer via deregulation of DNA damage-inducible transcript 3 (DDIT3), caveolin 1 (CAV1), and ribonucleotide reductase regulatory subunit M2 (RRM2). This domain lies N-terminal to the FAST_1 domain, and is predicted (by AlphaFold) to be alpha-helical, with similarity to structures of members of the 6-hairpin (6 helical hairpin) clan.


:

Pssm-ID: 467932 [Multi-domain]  Cd Length: 249  Bit Score: 202.11  E-value: 1.66e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654192  96 DSNQAAMVLIRLSHLLSEKPEDKGLLIQDAHFHQLLCLLNSQIASVWHGTLSKLLGSLYALGIPKASKELQSVEQEVRWR 175
Cdd:cd23739    1 SANCAALAVQRLSRLVVEGRAEKDLLLEDPRFEKLCRLAENQISSLSPGSLVDLLRSLLRLGIPPNSRLLQSLENEVRWR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654192 176 MRKLKYKHLAFLAESCATLSQEQHSQELLAELLTHLERRWTEIEDSHTLVTVMMKVGHLSEPLMNRLEDKhVLNRAQDIT 255
Cdd:cd23739   81 LRRLSFRHLASLAESLATLQRAQEQKELLSELLKLLERRWTEIEDPRDLVTLMRIVGHLSPLLMNRLEDK-ALELLEQFT 159

                        170
                 ....*....|....*.
gi 929654192 256 LPHLCSVLLAFARLNF 271
Cdd:cd23739  160 LEELRRVLLTLAAQKR 175
FAST_2 pfam08368
FAST kinase-like protein, subdomain 2; This family represents a conserved region of eukaryotic ...
 341-426 6.98e-29

FAST kinase-like protein, subdomain 2; This family represents a conserved region of eukaryotic Fas-activated serine/threonine (FAST) kinases (EC:2.7.1.-) that contains several conserved leucine residues. FAST kinase is rapidly activated during Fas-mediated apoptosis, when it phosphorylates TIA-1, a nuclear RNA-binding protein that has been implicated as an effector of apoptosis. Note that many family members are hypothetical proteins. This subdomain is often found associated with the FAST kinase-like protein, subdomain 2.


:

Pssm-ID: 462448  Cd Length: 89  Bit Score: 109.19  E-value: 6.98e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654192  341 FQKLLHINATALLEYPEYSGPLLPASAVAP---GPSALDRKVTPLQKELQETLKGLLGSADKGSLEVATQYGWVLDAEVL 417
Cdd:pfam08368   1 RLKLLQLNATVCLECPEYKGPWLPPKYCVKsfkVPLSSSKKKSPLQKEVLEALKELLGGENYFRSNVLTPYGYTIDFECK 80


                  ....*....
gi 929654192  418 LDSDGEFLP 426
Cdd:pfam08368  81 LDKDGKPLP 89
FAST_1 pfam06743
FAST kinase-like protein, subdomain 1; This family represents a conserved region of eukaryotic ...
 259-330 9.17e-23

FAST kinase-like protein, subdomain 1; This family represents a conserved region of eukaryotic Fas-activated serine/threonine (FAST) kinases (EC:2.7.1.-) that contains several conserved leucine residues. FAST kinase is rapidly activated during Fas-mediated apoptosis, when it phosphorylates TIA-1, a nuclear RNA-binding protein that has been implicated as an effector of apoptosis. Note that many family members are hypothetical proteins. This region is often found immediately N-terminal to the FAST kinase-like protein, subdomain 2.


:

Pssm-ID: 461999 [Multi-domain]  Cd Length: 72  Bit Score: 91.78  E-value: 9.17e-23
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 929654192  259 LCSVLLAFARLNFHPDQEDQFFSLVHEKLGSELPGLEPALQVDLVWALCVLQQAREAELQAVLHPEFHIQFL 330
Cdd:pfam06743   1 LLSLLLPFARLNYLPPNAEEFFEKLESVLESYLSSFSPELLLDLVWSLCVLGRFPEALLNKVLSPDFLQKLL 72
RAP smart00952
This domain is found in various eukaryotic species, particularly in apicomplexans; In ...
 453-510 1.67e-13

This domain is found in various eukaryotic species, particularly in apicomplexans; In Plasmodium falciparum, the domain is found in proteins that are important in various parasite-host cell interactions. It is thought to be an RNA-binding domain.


:

Pssm-ID: 214932  Cd Length: 58  Bit Score: 64.95  E-value: 1.67e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 929654192   453 FLRWEFPNFNSRSKDLLGRFVLARRHIVAAGFLIVDVPFYEWLELKSEWQKGAYLKDK 510
Cdd:smart00952   1 IEVDGPSHFCRNSRHLLGRLALKKRHLEALGYKVISIPYYEWNKLKSEDEKVEYLKEK 58
 
Name Accession Description Interval E-value
TBRG4-like_N cd23739
transforming growth factor beta (TGFbeta) regulator 4 (TBRG4) and similar proteins; predicted ...
 96-271 1.66e-61

transforming growth factor beta (TGFbeta) regulator 4 (TBRG4) and similar proteins; predicted alpha-helical domain N-terminal to FAST kinase-like protein, subdomain 1 (FAST_1); TBRG4 also called cell cycle progression restoration protein 2 or Fas-activated serine-threonine (FAST) kinase domain-containing protein 4, is a regulator of TGFbeta and is implicated in numerous types of cancer. It serves a role in the tumorigenesis of lung cancer via deregulation of DNA damage-inducible transcript 3 (DDIT3), caveolin 1 (CAV1), and ribonucleotide reductase regulatory subunit M2 (RRM2). This domain lies N-terminal to the FAST_1 domain, and is predicted (by AlphaFold) to be alpha-helical, with similarity to structures of members of the 6-hairpin (6 helical hairpin) clan.


Pssm-ID: 467932 [Multi-domain]  Cd Length: 249  Bit Score: 202.11  E-value: 1.66e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654192  96 DSNQAAMVLIRLSHLLSEKPEDKGLLIQDAHFHQLLCLLNSQIASVWHGTLSKLLGSLYALGIPKASKELQSVEQEVRWR 175
Cdd:cd23739    1 SANCAALAVQRLSRLVVEGRAEKDLLLEDPRFEKLCRLAENQISSLSPGSLVDLLRSLLRLGIPPNSRLLQSLENEVRWR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654192 176 MRKLKYKHLAFLAESCATLSQEQHSQELLAELLTHLERRWTEIEDSHTLVTVMMKVGHLSEPLMNRLEDKhVLNRAQDIT 255
Cdd:cd23739   81 LRRLSFRHLASLAESLATLQRAQEQKELLSELLKLLERRWTEIEDPRDLVTLMRIVGHLSPLLMNRLEDK-ALELLEQFT 159

                        170
                 ....*....|....*.
gi 929654192 256 LPHLCSVLLAFARLNF 271
Cdd:cd23739  160 LEELRRVLLTLAAQKR 175
FAST_2 pfam08368
FAST kinase-like protein, subdomain 2; This family represents a conserved region of eukaryotic ...
 341-426 6.98e-29

FAST kinase-like protein, subdomain 2; This family represents a conserved region of eukaryotic Fas-activated serine/threonine (FAST) kinases (EC:2.7.1.-) that contains several conserved leucine residues. FAST kinase is rapidly activated during Fas-mediated apoptosis, when it phosphorylates TIA-1, a nuclear RNA-binding protein that has been implicated as an effector of apoptosis. Note that many family members are hypothetical proteins. This subdomain is often found associated with the FAST kinase-like protein, subdomain 2.


Pssm-ID: 462448  Cd Length: 89  Bit Score: 109.19  E-value: 6.98e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654192  341 FQKLLHINATALLEYPEYSGPLLPASAVAP---GPSALDRKVTPLQKELQETLKGLLGSADKGSLEVATQYGWVLDAEVL 417
Cdd:pfam08368   1 RLKLLQLNATVCLECPEYKGPWLPPKYCVKsfkVPLSSSKKKSPLQKEVLEALKELLGGENYFRSNVLTPYGYTIDFECK 80


                  ....*....
gi 929654192  418 LDSDGEFLP 426
Cdd:pfam08368  81 LDKDGKPLP 89
FAST_1 pfam06743
FAST kinase-like protein, subdomain 1; This family represents a conserved region of eukaryotic ...
 259-330 9.17e-23

FAST kinase-like protein, subdomain 1; This family represents a conserved region of eukaryotic Fas-activated serine/threonine (FAST) kinases (EC:2.7.1.-) that contains several conserved leucine residues. FAST kinase is rapidly activated during Fas-mediated apoptosis, when it phosphorylates TIA-1, a nuclear RNA-binding protein that has been implicated as an effector of apoptosis. Note that many family members are hypothetical proteins. This region is often found immediately N-terminal to the FAST kinase-like protein, subdomain 2.


Pssm-ID: 461999 [Multi-domain]  Cd Length: 72  Bit Score: 91.78  E-value: 9.17e-23
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 929654192  259 LCSVLLAFARLNFHPDQEDQFFSLVHEKLGSELPGLEPALQVDLVWALCVLQQAREAELQAVLHPEFHIQFL 330
Cdd:pfam06743   1 LLSLLLPFARLNYLPPNAEEFFEKLESVLESYLSSFSPELLLDLVWSLCVLGRFPEALLNKVLSPDFLQKLL 72
RAP smart00952
This domain is found in various eukaryotic species, particularly in apicomplexans; In ...
 453-510 1.67e-13

This domain is found in various eukaryotic species, particularly in apicomplexans; In Plasmodium falciparum, the domain is found in proteins that are important in various parasite-host cell interactions. It is thought to be an RNA-binding domain.


Pssm-ID: 214932  Cd Length: 58  Bit Score: 64.95  E-value: 1.67e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 929654192   453 FLRWEFPNFNSRSKDLLGRFVLARRHIVAAGFLIVDVPFYEWLELKSEWQKGAYLKDK 510
Cdd:smart00952   1 IEVDGPSHFCRNSRHLLGRLALKKRHLEALGYKVISIPYYEWNKLKSEDEKVEYLKEK 58
RAP pfam08373
RAP domain; This domain is found in various eukaryotic species, where it is found in proteins ...
 456-510 2.45e-11

RAP domain; This domain is found in various eukaryotic species, where it is found in proteins that are important in various parasite-host cell interactions. It is thought to be an RNA-binding domain. The domain is involved in plant defence in response to bacterial infection.


Pssm-ID: 429953  Cd Length: 58  Bit Score: 58.75  E-value: 2.45e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 929654192  456 WEFPNFNSRSKDLLGRFVLARRHIVAAGFLIVDVPFYEWLELKSEWQKGAYLKDK 510
Cdd:pfam08373   4 DGPSHFYRNSKQLTGSTKLKHRLLSALGYKVISIPYYEWNQLKTKEEKVEYLKKK 58
 
Name Accession Description Interval E-value
TBRG4-like_N cd23739
transforming growth factor beta (TGFbeta) regulator 4 (TBRG4) and similar proteins; predicted ...
 96-271 1.66e-61

transforming growth factor beta (TGFbeta) regulator 4 (TBRG4) and similar proteins; predicted alpha-helical domain N-terminal to FAST kinase-like protein, subdomain 1 (FAST_1); TBRG4 also called cell cycle progression restoration protein 2 or Fas-activated serine-threonine (FAST) kinase domain-containing protein 4, is a regulator of TGFbeta and is implicated in numerous types of cancer. It serves a role in the tumorigenesis of lung cancer via deregulation of DNA damage-inducible transcript 3 (DDIT3), caveolin 1 (CAV1), and ribonucleotide reductase regulatory subunit M2 (RRM2). This domain lies N-terminal to the FAST_1 domain, and is predicted (by AlphaFold) to be alpha-helical, with similarity to structures of members of the 6-hairpin (6 helical hairpin) clan.


Pssm-ID: 467932 [Multi-domain]  Cd Length: 249  Bit Score: 202.11  E-value: 1.66e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654192  96 DSNQAAMVLIRLSHLLSEKPEDKGLLIQDAHFHQLLCLLNSQIASVWHGTLSKLLGSLYALGIPKASKELQSVEQEVRWR 175
Cdd:cd23739    1 SANCAALAVQRLSRLVVEGRAEKDLLLEDPRFEKLCRLAENQISSLSPGSLVDLLRSLLRLGIPPNSRLLQSLENEVRWR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654192 176 MRKLKYKHLAFLAESCATLSQEQHSQELLAELLTHLERRWTEIEDSHTLVTVMMKVGHLSEPLMNRLEDKhVLNRAQDIT 255
Cdd:cd23739   81 LRRLSFRHLASLAESLATLQRAQEQKELLSELLKLLERRWTEIEDPRDLVTLMRIVGHLSPLLMNRLEDK-ALELLEQFT 159

                        170
                 ....*....|....*.
gi 929654192 256 LPHLCSVLLAFARLNF 271
Cdd:cd23739  160 LEELRRVLLTLAAQKR 175
FAST_2 pfam08368
FAST kinase-like protein, subdomain 2; This family represents a conserved region of eukaryotic ...
 341-426 6.98e-29

FAST kinase-like protein, subdomain 2; This family represents a conserved region of eukaryotic Fas-activated serine/threonine (FAST) kinases (EC:2.7.1.-) that contains several conserved leucine residues. FAST kinase is rapidly activated during Fas-mediated apoptosis, when it phosphorylates TIA-1, a nuclear RNA-binding protein that has been implicated as an effector of apoptosis. Note that many family members are hypothetical proteins. This subdomain is often found associated with the FAST kinase-like protein, subdomain 2.


Pssm-ID: 462448  Cd Length: 89  Bit Score: 109.19  E-value: 6.98e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 929654192  341 FQKLLHINATALLEYPEYSGPLLPASAVAP---GPSALDRKVTPLQKELQETLKGLLGSADKGSLEVATQYGWVLDAEVL 417
Cdd:pfam08368   1 RLKLLQLNATVCLECPEYKGPWLPPKYCVKsfkVPLSSSKKKSPLQKEVLEALKELLGGENYFRSNVLTPYGYTIDFECK 80


                  ....*....
gi 929654192  418 LDSDGEFLP 426
Cdd:pfam08368  81 LDKDGKPLP 89
FAST_1 pfam06743
FAST kinase-like protein, subdomain 1; This family represents a conserved region of eukaryotic ...
 259-330 9.17e-23

FAST kinase-like protein, subdomain 1; This family represents a conserved region of eukaryotic Fas-activated serine/threonine (FAST) kinases (EC:2.7.1.-) that contains several conserved leucine residues. FAST kinase is rapidly activated during Fas-mediated apoptosis, when it phosphorylates TIA-1, a nuclear RNA-binding protein that has been implicated as an effector of apoptosis. Note that many family members are hypothetical proteins. This region is often found immediately N-terminal to the FAST kinase-like protein, subdomain 2.


Pssm-ID: 461999 [Multi-domain]  Cd Length: 72  Bit Score: 91.78  E-value: 9.17e-23
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 929654192  259 LCSVLLAFARLNFHPDQEDQFFSLVHEKLGSELPGLEPALQVDLVWALCVLQQAREAELQAVLHPEFHIQFL 330
Cdd:pfam06743   1 LLSLLLPFARLNYLPPNAEEFFEKLESVLESYLSSFSPELLLDLVWSLCVLGRFPEALLNKVLSPDFLQKLL 72
RAP smart00952
This domain is found in various eukaryotic species, particularly in apicomplexans; In ...
 453-510 1.67e-13

This domain is found in various eukaryotic species, particularly in apicomplexans; In Plasmodium falciparum, the domain is found in proteins that are important in various parasite-host cell interactions. It is thought to be an RNA-binding domain.


Pssm-ID: 214932  Cd Length: 58  Bit Score: 64.95  E-value: 1.67e-13
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 929654192   453 FLRWEFPNFNSRSKDLLGRFVLARRHIVAAGFLIVDVPFYEWLELKSEWQKGAYLKDK 510
Cdd:smart00952   1 IEVDGPSHFCRNSRHLLGRLALKKRHLEALGYKVISIPYYEWNKLKSEDEKVEYLKEK 58
RAP pfam08373
RAP domain; This domain is found in various eukaryotic species, where it is found in proteins ...
 456-510 2.45e-11

RAP domain; This domain is found in various eukaryotic species, where it is found in proteins that are important in various parasite-host cell interactions. It is thought to be an RNA-binding domain. The domain is involved in plant defence in response to bacterial infection.


Pssm-ID: 429953  Cd Length: 58  Bit Score: 58.75  E-value: 2.45e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 929654192  456 WEFPNFNSRSKDLLGRFVLARRHIVAAGFLIVDVPFYEWLELKSEWQKGAYLKDK 510
Cdd:pfam08373   4 DGPSHFYRNSKQLTGSTKLKHRLLSALGYKVISIPYYEWNQLKTKEEKVEYLKKK 58
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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