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Conserved domains on  [gi|6939732|dbj|BAA90665|]
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transcription factor Elongin A2 [Homo sapiens]

Protein Classification

TFIIS_I domain-containing protein( domain architecture ID 11271078)

TFIIS_I domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Elongin_A pfam06881
RNA polymerase II transcription factor SIII (Elongin) subunit A; This family represents a ...
 544-642 2.34e-19

RNA polymerase II transcription factor SIII (Elongin) subunit A; This family represents a conserved region within RNA polymerase II transcription factor SIII (Elongin) subunit A. In mammals, the Elongin complex activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin is a heterotrimer composed of A, B, and C subunits of 110, 18, and 15 kilodaltons, respectively. Subunit A has been shown to function as the transcriptionally active component of Elongin.


:

Pssm-ID: 462026  Cd Length: 105  Bit Score: 83.81  E-value: 2.34e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6939732    544 LSDVGEVPYWVLEPVLEGWRPDQLYRRKKDNHALVRETDELRRNHCFQDFKEE------KPQENKTWREQYLRLPDAPEQ 617
Cdd:pfam06881   1 IDDVGDVPYHLLRPILLKCSPEQLRRIEENSPHLAGDTDELWKRFIKRDFPNWaeekdyEPKNPKSWRKLYEKLKEEREE 80

                          90       100
                  ....*....|....*....|....*
gi 6939732    618 RLRVMTTNIRSARGNNPNGREAKMI 642
Cdd:pfam06881  81 KLKAAAERLRQAYAGLQKEKQSKQI 105
TFS2N smart00509
Domain in the N-terminus of transcription elongation factor S-II (and elsewhere);
8-77 8.05e-18

Domain in the N-terminus of transcription elongation factor S-II (and elsewhere);


:

Pssm-ID: 197766 [Multi-domain]  Cd Length: 75  Bit Score: 78.51  E-value: 8.05e-18
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 6939732       8 LHAVEKLQVRLATKT-EPKKLEKYLQKLSALPMTADILAETGIRKTVKLLRKH--QHVGDFARDLAARWKKLV 77
Cdd:smart00509   1 LLRAAKKLDKVANNGkEVSRCLDILKKLKKLPITVDLLEETRIGKKVNGLRKHknEEIRKLAKKLIKSWKKLV 73
dnaA super family cl42516
chromosomal replication initiator protein DnaA;
81-205 5.73e-06

chromosomal replication initiator protein DnaA;


The actual alignment was detected with superfamily member PRK14086:

Pssm-ID: 455861 [Multi-domain]  Cd Length: 617  Bit Score: 49.82  E-value: 5.73e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6939732    81 RNTRPGPQDPEESASRQRFGEALQDQEKAWGFPENATAPRSPSHSPEHRRTarRTPPGQQRP----------HPRSHSRE 150
Cdd:PRK14086 143 RPAYPAYQQRPEPGAWPRAADDYGWQQQRLGFPPRAPYASPASYAPEQERD--REPYDAGRPeydqrrrdydHPRPDWDR 220

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 6939732   151 PRAERK-CPRIAPADSGRYRASPTRTAPLPMPEGPE-PAAPGKQPGRGHTHAAQGGP 205
Cdd:PRK14086 221 PRRDRTdRPEPPPGAGHVHRGGPGPPERDDAPVVPIrPSAPGPLAAQPAPAPGPGEP 277
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 113-365 5.19e-03

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 40.69  E-value: 5.19e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6939732    113 PENATAPRSPSHSPEHRRTArrtPPGQQRPHPRSHSREPRAERKCPRIAPADSGRYRASPTRTAPLPMPEGPEPAAPGKQ 192
Cdd:PHA03247 2766 PPAPAPPAAPAAGPPRRLTR---PAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPP 2842

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6939732    193 PGRGHTHAAQGGPlLCPGCQGQPQGKAVVSHSKGHKSSRQEKRLLCAqgdwhsPTLIREKSFGACLREETPRMPSWASAr 272
Cdd:PHA03247 2843 PGPPPPSLPLGGS-VAPGGDVRRRPPSRSPAAKPAAPARPPVRRLAR------PAVSRSTESFALPPDQPERPPQPQAP- 2914

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6939732    273 dRQPSDFKTDKEGGQAGSGQRVPALEEAPDShqkrPQHSHSNKKRPSLDGRDPGNG--THGLSPEEKEQLSNDRETQEG- 349
Cdd:PHA03247 2915 -PPPQPQPQPPPPPQPQPPPPPPPRPQPPLA----PTTDPAGAGEPSGAVPQPWLGalVPGRVAVPRFRVPQPAPSREAp 2989

                         250
                  ....*....|....*.
gi 6939732    350 KPPTAHLDRTSVSSLS 365
Cdd:PHA03247 2990 ASSTPPLTGHSLSRVS 3005
 
Name Accession Description Interval E-value
Elongin_A pfam06881
RNA polymerase II transcription factor SIII (Elongin) subunit A; This family represents a ...
 544-642 2.34e-19

RNA polymerase II transcription factor SIII (Elongin) subunit A; This family represents a conserved region within RNA polymerase II transcription factor SIII (Elongin) subunit A. In mammals, the Elongin complex activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin is a heterotrimer composed of A, B, and C subunits of 110, 18, and 15 kilodaltons, respectively. Subunit A has been shown to function as the transcriptionally active component of Elongin.


Pssm-ID: 462026  Cd Length: 105  Bit Score: 83.81  E-value: 2.34e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6939732    544 LSDVGEVPYWVLEPVLEGWRPDQLYRRKKDNHALVRETDELRRNHCFQDFKEE------KPQENKTWREQYLRLPDAPEQ 617
Cdd:pfam06881   1 IDDVGDVPYHLLRPILLKCSPEQLRRIEENSPHLAGDTDELWKRFIKRDFPNWaeekdyEPKNPKSWRKLYEKLKEEREE 80

                          90       100
                  ....*....|....*....|....*
gi 6939732    618 RLRVMTTNIRSARGNNPNGREAKMI 642
Cdd:pfam06881  81 KLKAAAERLRQAYAGLQKEKQSKQI 105
TFS2N smart00509
Domain in the N-terminus of transcription elongation factor S-II (and elsewhere);
8-77 8.05e-18

Domain in the N-terminus of transcription elongation factor S-II (and elsewhere);


Pssm-ID: 197766 [Multi-domain]  Cd Length: 75  Bit Score: 78.51  E-value: 8.05e-18
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 6939732       8 LHAVEKLQVRLATKT-EPKKLEKYLQKLSALPMTADILAETGIRKTVKLLRKH--QHVGDFARDLAARWKKLV 77
Cdd:smart00509   1 LLRAAKKLDKVANNGkEVSRCLDILKKLKKLPITVDLLEETRIGKKVNGLRKHknEEIRKLAKKLIKSWKKLV 73
TFIIS_I cd00183
N-terminal domain (domain I) of transcription elongation factor S-II (TFIIS); similar to a ...
 7-77 3.72e-17

N-terminal domain (domain I) of transcription elongation factor S-II (TFIIS); similar to a domain found in elongin A and CRSP70; likely to be involved in transcription; domain I from TFIIS interacts with RNA polymerase II holoenzyme


Pssm-ID: 238107  Cd Length: 76  Bit Score: 76.58  E-value: 3.72e-17
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 6939732    7 TLHAVEKLQVRLATKtEPKKLEKYLQKLSALPMTADILAETGIRKTVKLLRKHQ--HVGDFARDLAARWKKLV 77
Cdd:cd00183   4 VLRAKKKLEKKDSNE-EVSRLLDLLRLLKKLPLTVEILKETRIGKKVNSLRKHSneKIRKLAKALIKSWKKLV 75
Med26 pfam08711
TFIIS helical bundle-like domain; Mediator is a large complex of up to 33 proteins that is ...
 29-77 5.07e-11

TFIIS helical bundle-like domain; Mediator is a large complex of up to 33 proteins that is conserved from plants to fungi to humans - the number and representation of individual subunits varying with species {1-2]. It is arranged into four different sections, a core, a head, a tail and a kinase-activity part, and the number of subunits within each of these is what varies with species. Overall, Mediator regulates the transcriptional activity of RNA polymerase II but it would appear that each of the four different sections has a slightly different function. Mediator exists in two major forms in human cells: a smaller form that interacts strongly with pol II and activates transcription, and a large form that does not interact strongly with pol II and does not directly activate transcription. Notably, the 'small' and 'large' Mediator complexes differ in their subunit composition: the Med26 subunit preferentially associates with the small, active complex, whereas cdk8, cyclin C, Med12 and Med13 associate with the large Mediator complex. This family includesthe C terminal region of a number of eukaryotic hypothetical proteins which are homologous to the Saccharomyces cerevisiae protein IWS1. IWS1 is known to be an Pol II transcription elongation factor and interacts with Spt6 and Spt5.


Pssm-ID: 462573 [Multi-domain]  Cd Length: 52  Bit Score: 58.30  E-value: 5.07e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 6939732     29 KYLQKLSALPMTADILAETGIRKTVKLLRKH---QHVGDFARDLAARWKKLV 77
Cdd:pfam08711   1 KLLKKLEKLPVTLELLKSTGIGKVVNKLRKHkenPEIKKLAKELVKKWKRLV 52
dnaA PRK14086
chromosomal replication initiator protein DnaA;
81-205 5.73e-06

chromosomal replication initiator protein DnaA;


Pssm-ID: 237605 [Multi-domain]  Cd Length: 617  Bit Score: 49.82  E-value: 5.73e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6939732    81 RNTRPGPQDPEESASRQRFGEALQDQEKAWGFPENATAPRSPSHSPEHRRTarRTPPGQQRP----------HPRSHSRE 150
Cdd:PRK14086 143 RPAYPAYQQRPEPGAWPRAADDYGWQQQRLGFPPRAPYASPASYAPEQERD--REPYDAGRPeydqrrrdydHPRPDWDR 220

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 6939732   151 PRAERK-CPRIAPADSGRYRASPTRTAPLPMPEGPE-PAAPGKQPGRGHTHAAQGGP 205
Cdd:PRK14086 221 PRRDRTdRPEPPPGAGHVHRGGPGPPERDDAPVVPIrPSAPGPLAAQPAPAPGPGEP 277
TFSII TIGR01385
transcription elongation factor S-II; This model represents eukaryotic transcription ...
 29-91 6.88e-04

transcription elongation factor S-II; This model represents eukaryotic transcription elongation factor S-II. This protein allows stalled RNA transcription complexes to perform a cleavage of the nascent RNA and restart at the newly generated 3-prime end.


Pssm-ID: 273592 [Multi-domain]  Cd Length: 299  Bit Score: 42.52  E-value: 6.88e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 6939732     29 KYLQKLSALPMTADILAETGIRKTVKLLRKH--QHVGDFARDLAARWKKLVLVDRNTRPGPQDPE 91
Cdd:TIGR01385  25 DILHQLKEFPPTEELLQETKVGVKVNKLRKHpnEDISKLAKKIIKSWKKVVDKNKSDHPGGNPED 89
DUF6264 pfam19779
Family of unknown function (DUF6264); This family of putative integral membrane proteins is ...
 136-198 1.49e-03

Family of unknown function (DUF6264); This family of putative integral membrane proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are typically between 179 and 218 amino acids in length.


Pssm-ID: 466182  Cd Length: 182  Bit Score: 40.33  E-value: 1.49e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 6939732    136 PPGQQRPHPRshsREPRAERKCPRIAPADSGRYRAS-PTRTAPLPMPEGPEPAAPGKQPGRGHT 198
Cdd:pfam19779   9 PPGWQRAPIG---DPAAAAAAAPPAAPAPAAPAPPAaPAAPPAAPPPPGAPAPGAPAAARRARR 69
PHA03247 PHA03247
large tegument protein UL36; Provisional
 113-365 5.19e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 40.69  E-value: 5.19e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6939732    113 PENATAPRSPSHSPEHRRTArrtPPGQQRPHPRSHSREPRAERKCPRIAPADSGRYRASPTRTAPLPMPEGPEPAAPGKQ 192
Cdd:PHA03247 2766 PPAPAPPAAPAAGPPRRLTR---PAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPP 2842

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6939732    193 PGRGHTHAAQGGPlLCPGCQGQPQGKAVVSHSKGHKSSRQEKRLLCAqgdwhsPTLIREKSFGACLREETPRMPSWASAr 272
Cdd:PHA03247 2843 PGPPPPSLPLGGS-VAPGGDVRRRPPSRSPAAKPAAPARPPVRRLAR------PAVSRSTESFALPPDQPERPPQPQAP- 2914

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6939732    273 dRQPSDFKTDKEGGQAGSGQRVPALEEAPDShqkrPQHSHSNKKRPSLDGRDPGNG--THGLSPEEKEQLSNDRETQEG- 349
Cdd:PHA03247 2915 -PPPQPQPQPPPPPQPQPPPPPPPRPQPPLA----PTTDPAGAGEPSGAVPQPWLGalVPGRVAVPRFRVPQPAPSREAp 2989

                         250
                  ....*....|....*.
gi 6939732    350 KPPTAHLDRTSVSSLS 365
Cdd:PHA03247 2990 ASSTPPLTGHSLSRVS 3005
 
Name Accession Description Interval E-value
Elongin_A pfam06881
RNA polymerase II transcription factor SIII (Elongin) subunit A; This family represents a ...
 544-642 2.34e-19

RNA polymerase II transcription factor SIII (Elongin) subunit A; This family represents a conserved region within RNA polymerase II transcription factor SIII (Elongin) subunit A. In mammals, the Elongin complex activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin is a heterotrimer composed of A, B, and C subunits of 110, 18, and 15 kilodaltons, respectively. Subunit A has been shown to function as the transcriptionally active component of Elongin.


Pssm-ID: 462026  Cd Length: 105  Bit Score: 83.81  E-value: 2.34e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6939732    544 LSDVGEVPYWVLEPVLEGWRPDQLYRRKKDNHALVRETDELRRNHCFQDFKEE------KPQENKTWREQYLRLPDAPEQ 617
Cdd:pfam06881   1 IDDVGDVPYHLLRPILLKCSPEQLRRIEENSPHLAGDTDELWKRFIKRDFPNWaeekdyEPKNPKSWRKLYEKLKEEREE 80

                          90       100
                  ....*....|....*....|....*
gi 6939732    618 RLRVMTTNIRSARGNNPNGREAKMI 642
Cdd:pfam06881  81 KLKAAAERLRQAYAGLQKEKQSKQI 105
TFS2N smart00509
Domain in the N-terminus of transcription elongation factor S-II (and elsewhere);
8-77 8.05e-18

Domain in the N-terminus of transcription elongation factor S-II (and elsewhere);


Pssm-ID: 197766 [Multi-domain]  Cd Length: 75  Bit Score: 78.51  E-value: 8.05e-18
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 6939732       8 LHAVEKLQVRLATKT-EPKKLEKYLQKLSALPMTADILAETGIRKTVKLLRKH--QHVGDFARDLAARWKKLV 77
Cdd:smart00509   1 LLRAAKKLDKVANNGkEVSRCLDILKKLKKLPITVDLLEETRIGKKVNGLRKHknEEIRKLAKKLIKSWKKLV 73
TFIIS_I cd00183
N-terminal domain (domain I) of transcription elongation factor S-II (TFIIS); similar to a ...
 7-77 3.72e-17

N-terminal domain (domain I) of transcription elongation factor S-II (TFIIS); similar to a domain found in elongin A and CRSP70; likely to be involved in transcription; domain I from TFIIS interacts with RNA polymerase II holoenzyme


Pssm-ID: 238107  Cd Length: 76  Bit Score: 76.58  E-value: 3.72e-17
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 6939732    7 TLHAVEKLQVRLATKtEPKKLEKYLQKLSALPMTADILAETGIRKTVKLLRKHQ--HVGDFARDLAARWKKLV 77
Cdd:cd00183   4 VLRAKKKLEKKDSNE-EVSRLLDLLRLLKKLPLTVEILKETRIGKKVNSLRKHSneKIRKLAKALIKSWKKLV 75
Med26 pfam08711
TFIIS helical bundle-like domain; Mediator is a large complex of up to 33 proteins that is ...
 29-77 5.07e-11

TFIIS helical bundle-like domain; Mediator is a large complex of up to 33 proteins that is conserved from plants to fungi to humans - the number and representation of individual subunits varying with species {1-2]. It is arranged into four different sections, a core, a head, a tail and a kinase-activity part, and the number of subunits within each of these is what varies with species. Overall, Mediator regulates the transcriptional activity of RNA polymerase II but it would appear that each of the four different sections has a slightly different function. Mediator exists in two major forms in human cells: a smaller form that interacts strongly with pol II and activates transcription, and a large form that does not interact strongly with pol II and does not directly activate transcription. Notably, the 'small' and 'large' Mediator complexes differ in their subunit composition: the Med26 subunit preferentially associates with the small, active complex, whereas cdk8, cyclin C, Med12 and Med13 associate with the large Mediator complex. This family includesthe C terminal region of a number of eukaryotic hypothetical proteins which are homologous to the Saccharomyces cerevisiae protein IWS1. IWS1 is known to be an Pol II transcription elongation factor and interacts with Spt6 and Spt5.


Pssm-ID: 462573 [Multi-domain]  Cd Length: 52  Bit Score: 58.30  E-value: 5.07e-11
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|..
gi 6939732     29 KYLQKLSALPMTADILAETGIRKTVKLLRKH---QHVGDFARDLAARWKKLV 77
Cdd:pfam08711   1 KLLKKLEKLPVTLELLKSTGIGKVVNKLRKHkenPEIKKLAKELVKKWKRLV 52
dnaA PRK14086
chromosomal replication initiator protein DnaA;
81-205 5.73e-06

chromosomal replication initiator protein DnaA;


Pssm-ID: 237605 [Multi-domain]  Cd Length: 617  Bit Score: 49.82  E-value: 5.73e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6939732    81 RNTRPGPQDPEESASRQRFGEALQDQEKAWGFPENATAPRSPSHSPEHRRTarRTPPGQQRP----------HPRSHSRE 150
Cdd:PRK14086 143 RPAYPAYQQRPEPGAWPRAADDYGWQQQRLGFPPRAPYASPASYAPEQERD--REPYDAGRPeydqrrrdydHPRPDWDR 220

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 6939732   151 PRAERK-CPRIAPADSGRYRASPTRTAPLPMPEGPE-PAAPGKQPGRGHTHAAQGGP 205
Cdd:PRK14086 221 PRRDRTdRPEPPPGAGHVHRGGPGPPERDDAPVVPIrPSAPGPLAAQPAPAPGPGEP 277
TFSII TIGR01385
transcription elongation factor S-II; This model represents eukaryotic transcription ...
 29-91 6.88e-04

transcription elongation factor S-II; This model represents eukaryotic transcription elongation factor S-II. This protein allows stalled RNA transcription complexes to perform a cleavage of the nascent RNA and restart at the newly generated 3-prime end.


Pssm-ID: 273592 [Multi-domain]  Cd Length: 299  Bit Score: 42.52  E-value: 6.88e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 6939732     29 KYLQKLSALPMTADILAETGIRKTVKLLRKH--QHVGDFARDLAARWKKLVLVDRNTRPGPQDPE 91
Cdd:TIGR01385  25 DILHQLKEFPPTEELLQETKVGVKVNKLRKHpnEDISKLAKKIIKSWKKVVDKNKSDHPGGNPED 89
DUF6264 pfam19779
Family of unknown function (DUF6264); This family of putative integral membrane proteins is ...
 136-198 1.49e-03

Family of unknown function (DUF6264); This family of putative integral membrane proteins is functionally uncharacterized. This family of proteins is found in bacteria. Proteins in this family are typically between 179 and 218 amino acids in length.


Pssm-ID: 466182  Cd Length: 182  Bit Score: 40.33  E-value: 1.49e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 6939732    136 PPGQQRPHPRshsREPRAERKCPRIAPADSGRYRAS-PTRTAPLPMPEGPEPAAPGKQPGRGHT 198
Cdd:pfam19779   9 PPGWQRAPIG---DPAAAAAAAPPAAPAPAAPAPPAaPAAPPAAPPPPGAPAPGAPAAARRARR 69
PHA03378 PHA03378
EBNA-3B; Provisional
 113-217 4.86e-03

EBNA-3B; Provisional


Pssm-ID: 223065 [Multi-domain]  Cd Length: 991  Bit Score: 40.44  E-value: 4.86e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6939732   113 PENATAPRSPSHSPEHRRTARRTPPGQQRPHPRSHSREPRAERKCPRIAPADSGRYRASPTRTAPLPM-PEGPEPAAPGK 191
Cdd:PHA03378 697 PPRAPTPMRPPAAPPGRAQRPAAATGRARPPAAAPGRARPPAAAPGRARPPAAAPGRARPPAAAPGRArPPAAAPGAPTP 776

                         90       100
                 ....*....|....*....|....*.
gi 6939732   192 QPGRGHTHAAQGGPLLCPGCQGQPQG 217
Cdd:PHA03378 777 QPPPQAPPAPQQRPRGAPTPQPPPQA 802
PHA03247 PHA03247
large tegument protein UL36; Provisional
 113-365 5.19e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 40.69  E-value: 5.19e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6939732    113 PENATAPRSPSHSPEHRRTArrtPPGQQRPHPRSHSREPRAERKCPRIAPADSGRYRASPTRTAPLPMPEGPEPAAPGKQ 192
Cdd:PHA03247 2766 PPAPAPPAAPAAGPPRRLTR---PAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPP 2842

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6939732    193 PGRGHTHAAQGGPlLCPGCQGQPQGKAVVSHSKGHKSSRQEKRLLCAqgdwhsPTLIREKSFGACLREETPRMPSWASAr 272
Cdd:PHA03247 2843 PGPPPPSLPLGGS-VAPGGDVRRRPPSRSPAAKPAAPARPPVRRLAR------PAVSRSTESFALPPDQPERPPQPQAP- 2914

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6939732    273 dRQPSDFKTDKEGGQAGSGQRVPALEEAPDShqkrPQHSHSNKKRPSLDGRDPGNG--THGLSPEEKEQLSNDRETQEG- 349
Cdd:PHA03247 2915 -PPPQPQPQPPPPPQPQPPPPPPPRPQPPLA----PTTDPAGAGEPSGAVPQPWLGalVPGRVAVPRFRVPQPAPSREAp 2989

                         250
                  ....*....|....*.
gi 6939732    350 KPPTAHLDRTSVSSLS 365
Cdd:PHA03247 2990 ASSTPPLTGHSLSRVS 3005
PRK07764 PRK07764
DNA polymerase III subunits gamma and tau; Validated
 82-205 8.15e-03

DNA polymerase III subunits gamma and tau; Validated


Pssm-ID: 236090 [Multi-domain]  Cd Length: 824  Bit Score: 39.58  E-value: 8.15e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 6939732    82 NTRPGPQDPEESASRQRFGEALQDqekAWGFPENATAP----RSPSHSPEHRRTARRTPPGQQRPHPRSHSREPRAERKC 157
Cdd:PRK07764 642 APAPGVAAPEHHPKHVAVPDASDG---GDGWPAKAGGAapaaPPPAPAPAAPAAPAGAAPAQPAPAPAATPPAGQADDPA 718

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 6939732   158 PRIAPADSGRYRASPTRTAPLPMPEGPEPAAPGKQPGRGHTHAAQGGP 205
Cdd:PRK07764 719 AQPPQAAQGASAPSPAADDPVPLPPEPDDPPDPAGAPAQPPPPPAPAP 766
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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