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Conserved domains on  [gi|7022664|dbj|BAA91679|]
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unnamed protein product [Homo sapiens]

Protein Classification

MFS transporter( domain architecture ID 999995)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26758938|26098515
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
MFS super family cl28910
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
1-236 7.25e-155

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


The actual alignment was detected with superfamily member cd17455:

Pssm-ID: 475125  Cd Length: 407  Bit Score: 437.72  E-value: 7.25e-155
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7022664    1 MFYGTSAVATLLFILTAIAFKEKPRYPPSQAQAALQDSPPEEYSYKKSIRNLFKNIPFVLLLITYGIMTGAFYSVSTLLN 80
Cdd:cd17455 172 MFYGTAAVSTLLFILTIIVFKEKPPLPPSQAQAVLQGIPSEDYSYKQSIINLFKNVPFVLLLISYGIMTGTFYSVSTLLN 251
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7022664   81 QMILTYYEGEEVNAGRIGLTLVVAGMVGSILCGLWLDYTKTYKQTTLIVYILSFIGMVIFTFTLDLRYIIIVFVTGGVLG 160
Cdd:cd17455 252 QMIITHYEGEEVNAGRIGLTLVVAGMVGSILCGLWLDYTKTYKQTTLIVYILSFIGMVVFTFTLDLGYLIVVFVTGGVLG 331
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 7022664  161 FFMTGYLPLGFEFAVEITYPESEGTSSGLLNASAQIFGILFTLAQGKLTSDYGPKAGNIFLCVWMFIGIILTALIK 236
Cdd:cd17455 332 FFMTGYLPLGFEFAVEITYPESEGTSSGLLNASAQIFGIIFTLIQGKLTTDYGPQAGNIFLCAWIFVGIILTALIK 407
 
Name Accession Description Interval E-value
MFS_FLVCR1 cd17455
Feline leukemia virus subgroup C receptor-related protein 1 of the Major Facilitator ...
1-236 7.25e-155

Feline leukemia virus subgroup C receptor-related protein 1 of the Major Facilitator Superfamily of transporters; Feline leukemia virus subgroup C receptor-related protein 1 (FLVCR1) is also called feline leukemia virus subgroup C receptor (FLVCR). FLVCR1 is a heme transporter and it has two isoforms: 1 (or FLVCR1a), which exports cytoplasmic heme as well as coproporphyrin and protoporphyrin IX; and 2 (FLVCR1b), which promotes heme efflux from the mitochondrion to the cytoplasm. Mutations in the FLVCR1 gene have been linked to vision impairment, posterior column ataxia, and sensory neurodegeneration with loss of pain perception. FLVCR1 belongs to the Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341013  Cd Length: 407  Bit Score: 437.72  E-value: 7.25e-155
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7022664    1 MFYGTSAVATLLFILTAIAFKEKPRYPPSQAQAALQDSPPEEYSYKKSIRNLFKNIPFVLLLITYGIMTGAFYSVSTLLN 80
Cdd:cd17455 172 MFYGTAAVSTLLFILTIIVFKEKPPLPPSQAQAVLQGIPSEDYSYKQSIINLFKNVPFVLLLISYGIMTGTFYSVSTLLN 251
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7022664   81 QMILTYYEGEEVNAGRIGLTLVVAGMVGSILCGLWLDYTKTYKQTTLIVYILSFIGMVIFTFTLDLRYIIIVFVTGGVLG 160
Cdd:cd17455 252 QMIITHYEGEEVNAGRIGLTLVVAGMVGSILCGLWLDYTKTYKQTTLIVYILSFIGMVVFTFTLDLGYLIVVFVTGGVLG 331
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 7022664  161 FFMTGYLPLGFEFAVEITYPESEGTSSGLLNASAQIFGILFTLAQGKLTSDYGPKAGNIFLCVWMFIGIILTALIK 236
Cdd:cd17455 332 FFMTGYLPLGFEFAVEITYPESEGTSSGLLNASAQIFGIIFTLIQGKLTTDYGPQAGNIFLCAWIFVGIILTALIK 407
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
56-241 8.50e-15

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 73.37  E-value: 8.50e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7022664   56 IPFVLLLITYGIMTGAFYSVSTLLNQMILTYYEGEEVNAGRIGLTLVVAGMVGSILCGLWLDYT-KTYKQTTLIVYILSF 134
Cdd:COG2271 180 LRFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLgRRRKLVLAIGLLLAA 259
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7022664  135 IGMVIFTFTLDLRYIIIVFVtggVLGFFMTGYLPLGFEFAVEITYPESEGTSSGLLNASAQIFGILFTLAQGKLTSDYGP 214
Cdd:COG2271 260 LALLLLALLPSPALAIALLF---LAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGY 336
                       170       180
                ....*....|....*....|....*..
gi 7022664  215 KAGNIFLCVWMFIGIILTALIKSDLRR 241
Cdd:COG2271 337 QAAFLLLAALALLAALLALLLLRETRK 363
MFS_1 pfam07690
Major Facilitator Superfamily;
7-202 2.84e-05

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 44.72  E-value: 2.84e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7022664      7 AVATLLFILTAIAFKEKPRYPPSQAQAALQDSPPEEYSYKKSIRNLfkniPFVLLLITYGIMTGAFYSVSTLLNQMILTY 86
Cdd:pfam07690 155 LILAILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKALLRD----PVLWLLLALLLFGFAFFGLLTYLPLYQEVL 230
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7022664     87 YEGEEVNAGRIGLtLVVAGMVGSILCGLWLDYTKTYKQTTLIV--YILSFIGMVIFTFTLDLRYIIIVFVtggVLGFFMT 164
Cdd:pfam07690 231 GLSALLAGLLLGL-GGLLGAIGRLLLGRLSDRLGRRRRLLLALllLILAALGLLLLSLTLSSLWLLLALL---LLGFGFG 306
                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 7022664    165 GYLPLGFEFAVEITYPESEGTSSGLLNASAQIFGILFT 202
Cdd:pfam07690 307 LVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
2A0104 TIGR00881
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ...
103-213 3.86e-03

phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273319 [Multi-domain]  Cd Length: 379  Bit Score: 38.13  E-value: 3.86e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7022664    103 VAGMVGSILCGlWL---DYTKTYKQTTLIVYILSFIGMVIFTFTLDLRYIIIVfVTGGVLGFFMTGYLPLGFEFAVEITY 179
Cdd:TIGR00881 263 LGGLVGTLLAG-WLsdkLFNGRRGPLAVFFMALIIVSLLVYWLNPAANPLMDL-ICLFALGFLVYGPQMLIGVIASELAP 340
                          90       100       110
                  ....*....|....*....|....*....|....
gi 7022664    180 PESEGTSSGLLNASAQIFGILFTLAQGKLTSDYG 213
Cdd:TIGR00881 341 KKAAGTAAGFVGFFAYLGGILAGLPLGYLADGFG 374
 
Name Accession Description Interval E-value
MFS_FLVCR1 cd17455
Feline leukemia virus subgroup C receptor-related protein 1 of the Major Facilitator ...
1-236 7.25e-155

Feline leukemia virus subgroup C receptor-related protein 1 of the Major Facilitator Superfamily of transporters; Feline leukemia virus subgroup C receptor-related protein 1 (FLVCR1) is also called feline leukemia virus subgroup C receptor (FLVCR). FLVCR1 is a heme transporter and it has two isoforms: 1 (or FLVCR1a), which exports cytoplasmic heme as well as coproporphyrin and protoporphyrin IX; and 2 (FLVCR1b), which promotes heme efflux from the mitochondrion to the cytoplasm. Mutations in the FLVCR1 gene have been linked to vision impairment, posterior column ataxia, and sensory neurodegeneration with loss of pain perception. FLVCR1 belongs to the Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341013  Cd Length: 407  Bit Score: 437.72  E-value: 7.25e-155
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7022664    1 MFYGTSAVATLLFILTAIAFKEKPRYPPSQAQAALQDSPPEEYSYKKSIRNLFKNIPFVLLLITYGIMTGAFYSVSTLLN 80
Cdd:cd17455 172 MFYGTAAVSTLLFILTIIVFKEKPPLPPSQAQAVLQGIPSEDYSYKQSIINLFKNVPFVLLLISYGIMTGTFYSVSTLLN 251
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7022664   81 QMILTYYEGEEVNAGRIGLTLVVAGMVGSILCGLWLDYTKTYKQTTLIVYILSFIGMVIFTFTLDLRYIIIVFVTGGVLG 160
Cdd:cd17455 252 QMIITHYEGEEVNAGRIGLTLVVAGMVGSILCGLWLDYTKTYKQTTLIVYILSFIGMVVFTFTLDLGYLIVVFVTGGVLG 331
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 7022664  161 FFMTGYLPLGFEFAVEITYPESEGTSSGLLNASAQIFGILFTLAQGKLTSDYGPKAGNIFLCVWMFIGIILTALIK 236
Cdd:cd17455 332 FFMTGYLPLGFEFAVEITYPESEGTSSGLLNASAQIFGIIFTLIQGKLTTDYGPQAGNIFLCAWIFVGIILTALIK 407
MFS_FLVCR2 cd17456
Feline leukemia virus subgroup C receptor-related protein 2 of the Major Facilitator ...
1-236 2.10e-130

Feline leukemia virus subgroup C receptor-related protein 2 of the Major Facilitator Superfamily of transporters; Feline leukemia virus subgroup C receptor-related protein 2 (FLVCR2) is also called calcium-chelate transporter (CCT). It functions as a heme importer as well as a transporter for a calcium-chelator complex that is important for growth and calcium metabolism. Mutations in the FLVCR2 gene cause Proliferative vasculopathy and hydranencephaly-hydrocephaly syndrome (PVHH), also known as Fowler syndrome, a rare autosomal recessive disorder characterized by glomerular vasculopathy in the central nervous system, severe hydrocephaly, hypokinesia and arthrogryphosis. FLVCR2 belongs to the Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341014  Cd Length: 406  Bit Score: 375.66  E-value: 2.10e-130
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7022664    1 MFYGTSAVATLLFILTAIAFKEKPRYPPSQAQAALQDSPPEEYSYKKSIRNLFKNIPFVLLLITYGIMTGAFYSVSTLLN 80
Cdd:cd17456 171 MFYGTAAVATLLFILVIIVFQEKPKIPPSQAQAAIQSIPSQDYSYLQSILRLLKNVNFILLVVSYGLNTGCFYALSTLLN 250
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7022664   81 QMILTYYEGEEVNAGRIGLTLVVAGMVGSILCGLWLDYTKTYKQTTLIVYILSFIGMVIFTFTLDLRYIIIVFVTGGVLG 160
Cdd:cd17456 251 RMVIFHYPGEEVNAGRIGLTIVVAGMVGALISGIWLDRTKTYKQTTLAVYIMSLVGMVVYTFTLNLGHLWVVFITAGTLG 330
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 7022664  161 FFMTGYLPLGFEFAVEITYPESEGTSSGLLNASAQIFGILFTLAQGKLTSDYGPKAGNIFLCVWMFIGIILTALIK 236
Cdd:cd17456 331 FFMTGYLPLGFEFAAELTYPESEGTSSGLLNVSAQVFGIIFTISQGQIIDNFGTKAGNIFLCAFLLVGTILTALIK 406
MFS_FLVCR_like cd17398
Feline leukemia virus subgroup C receptor subfamily of the Major Facilitator Superfamily of ...
1-236 1.45e-128

Feline leukemia virus subgroup C receptor subfamily of the Major Facilitator Superfamily of transporters; The Feline leukemia virus subgroup C receptor (FLVCR) subfamily is conserved in metazoans and is composed of two vertebrate members, FLVCR1 and FLVCR2. FLVCR1 is a heme transporter and it has two isoforms: 1 (or FLVCR1a), which exports cytoplasmic heme as well as coproporphyrin and protoporphyrin IX; and 2 (FLVCR1b), which promotes heme efflux from the mitochondrion to the cytoplasm. FLVCR2 functions as a heme importer as well as a transporter for a calcium-chelator complex that is important for growth and calcium metabolism. The FLVCR subfamily belongs to the Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340956 [Multi-domain]  Cd Length: 406  Bit Score: 370.80  E-value: 1.45e-128
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7022664    1 MFYGTSAVATLLFILTAIAFKEKPRYPPSQAQAALQDSPPEEYSYKKSIRNLFKNIPFVLLLITYGIMTGAFYSVSTLLN 80
Cdd:cd17398 171 LFYGVAGICTALFILVIIFFKEKPPIPPSRAQAAAQELRSEDQSYLGSLKRLFKNKGFLLLLITYGINTGVYYAISTLLN 250
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7022664   81 QMILTYYEGEEVNAGRIGLTLVVAGMVGSILCGLWLDYTKTYKQTTLIVYILSFIGMVIFTFTLDLRYIIIVFVTGGVLG 160
Cdd:cd17398 251 QMVLEYFPNEEVNAGWIGLTLVIAGLVGSVVAGIWLDKTKKYKETTIIVYILSFIGMVAFTFTLDLGSIWVVFLTAGALG 330
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 7022664  161 FFMTGYLPLGFEFAVEITYPESEGTSSGLLNASAQIFGILFTLAQGKLTSDYGPKAGNIFLCVWMFIGIILTALIK 236
Cdd:cd17398 331 FFMTGYLPVGFEFAAELTYPEPEGTSSGLLNASAQIFGIIFTLVMGALLDKVGALASNIVLSVALLLGTILTAFIK 406
MFS_SLC49 cd17334
Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily of transporters; The ...
1-236 1.39e-87

Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily of transporters; The Solute carrier 49 (SLC49) family is composed of four members: feline leukemia virus subgroup C receptor 1 (FLVCR1, SLC49A1); FLVCR2 (SLC49A2); major facilitator superfamily domain-containing protein 7 (MFSD7, SLC49A3); and disrupted in renal carcinoma protein 2 (DIRC2, SLC49A4). FLVCR1 and FLVCR2 are heme transporters. In addition, FLVCR2 also functions as a transporter for a calcium-chelator complex that is important for growth and calcium metabolism. The function of MFSD7 is unknown. DIRC2 is an electrogenic lysosomal metabolite transporter that is regulated by limited proteolytic processing by cathepsin L. The SLC49 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340892 [Multi-domain]  Cd Length: 407  Bit Score: 266.57  E-value: 1.39e-87
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7022664    1 MFYGTSAVATLLFILTAIAFKEKPRYPPSQAQAALQDSPPEEYSYKKSIRNLFKNIPFVLLLITYGIMTGAFYSVSTLLN 80
Cdd:cd17334 169 VFYGEFGFACLLLALVLALFPPKPKYPPSAASARQQNSEHVILELQKSISELLRNEPFVLLAVAFSIMMGVFAGFSSVLA 248
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7022664   81 QMILTyYEGEEVNAGRIGLTLVVAGMVGSILCGLWLDYTktyKQTTLIVYILSFIGMVIFTFTLDLR-------YIIIVF 153
Cdd:cd17334 249 QILLP-FGVSQTSAGWLGFFGIVAGMVGGLLLGLFVDRT---RMFKLIGLIILALGTVVCTFFMLLVdryglpyVTLAFY 324
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7022664  154 VTGGVLGFFMTGYLPLGFEFAVEITYPESEGTSSGLLNASAQIFGILFTLAQGKLTSDYGPKAGNIFLCVWMFIGIILTA 233
Cdd:cd17334 325 LLCGLLGFFQNSMVPIMFELAVELTYPVPESVSTGVLTALANLFSFLLMLVFSELLGPTPTESKYLLWFILCTVGSCLGA 404

                ...
gi 7022664  234 LIK 236
Cdd:cd17334 405 LFF 407
MFS_MFSD7 cd17399
Major facilitator superfamily domain-containing protein 7; Major facilitator superfamily ...
1-205 3.62e-33

Major facilitator superfamily domain-containing protein 7; Major facilitator superfamily domain-containing protein 7 (MFSD7) is also called myosin light polypeptide 5 regulatory protein (MYL5). It's function is unknown. It is encoded by the a SLC49A3 gene and is a member of the Solute carrier 49 (SLC49) family, which also includes feline leukemia virus subgroup C receptor 1 (FLVCR1, SLC49A1), FLVCR2 (SLC49A2), as well as disrupted in renal carcinoma protein 2 (DIRC2, SLC49A4). FLVCR1 and FLVCR2 are heme transporters. DIRC2 is an electrogenic lysosomal metabolite transporter that is regulated by limited proteolytic processing by cathepsin L. MFSD7 belongs to the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340957  Cd Length: 419  Bit Score: 125.07  E-value: 3.62e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7022664    1 MFYGTSAVATLLFILTAIAFKEKPRYPPSQAQAALQDSPpeeysYKKSIRNLFKNIPFVLLLITYGIMTGAFYSVSTLLN 80
Cdd:cd17399 169 LLSIYTIPALIAVVLATFGVRSSVPPTPPSASAAHESEP-----FFVGLKQLFKNKQYLILMLCFGGGIGLFNALSTLLE 243
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7022664   81 QMILTYYEGEEVnAGRIGLTLVVAGMVGSILCGLWLDYTKTYKQTTLIVYILSFIGMVIFTFTLDLRYI-IIVFVTGGVL 159
Cdd:cd17399 244 QILCPSGYSNNF-AGICGALMIGVGLIGAFVAGLIVDKTKKFIEVTKVCFCLAVIFLVAFLVVSRFPNQsVLLAVLCGLF 322
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*.
gi 7022664  160 GFFMTGYLPLGFEFAVEITYPESEGTSSGLLNASAQIFGILFTLAQ 205
Cdd:cd17399 323 GFFGFAIYPVGLELAVECTYPVAEATSTGLIFMSGQIQGIILVFIM 368
MFS_DIRC2 cd17397
Disrupted in renal carcinoma protein 2 of the Major Facilitator Superfamily of transporters; ...
3-203 1.71e-25

Disrupted in renal carcinoma protein 2 of the Major Facilitator Superfamily of transporters; Disrupted in renal carcinoma protein 2 or disrupted in renal cancer protein 2 (DIRC2), encoded by the SLC49A4 gene, was initially identified as a breakpoint-spanning gene in a chromosomal translocation associated with the development of renal cancer. It is an electrogenic lysosomal metabolite transporter that is regulated by limited proteolytic processing by cathepsin L. DIRC2 belongs to the Solute carrier 49 (SLC49) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340955 [Multi-domain]  Cd Length: 381  Bit Score: 103.92  E-value: 1.71e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7022664    3 YGTSAVATLLFILTAIAFKEKPRYPPSQAQAAlqdsppEEYSYKKSIRNLFKNIPFVLLLITYGIMTGAFYSVSTLLNqM 82
Cdd:cd17397 158 YLEFGWSALIFLAMLIYFPSKPPTPPSVSAST------QRLSYKSGILSLLKNKRFWLIALAYGIPTGVYAGWSGVLD-V 230
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7022664   83 ILTYYEGEEVNAGRIGLTLVVAGMVGSILCGLWLDY-TKTYKQTTLIVYILSFIGMVIFTFTLdLRYI----IIVFVTGG 157
Cdd:cd17397 231 NLTPFGVSQVEAGWIGFYSTVAGCVGGIIVGRFADRfGGRMKLILLLLFSGATGSFLWFTLIC-LKLLpfstVSLYTSCI 309
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*.
gi 7022664  158 VLGFFMTGYLPLGFEFAVEITYPESEGTSSGLLNASAQIFGILFTL 203
Cdd:cd17397 310 LLGVFLNGSVPLFYELAVEAAYPVPEGITSGVLTFLNNVFGLVFLL 355
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
7-232 1.67e-20

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 89.79  E-value: 1.67e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7022664    7 AVATLLFILTAIAFKEKPRYPPSQAQAalQDSPPEEYSYKKSIRNLFKNIPFVLLLITYGIMTGAFYSVSTLLNQMILTY 86
Cdd:cd06174 156 LIAAALALLAAILLLLVVPDPPESARA--KNEEASSKSVLKLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDL 233
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7022664   87 YEGEEVNAGRIGLTLVVAGMVGSILCGLWLDYTKtykqTTLIVYILSFIGMVIFTFTLDL-RYIIIVFVTGGVLGFFMTG 165
Cdd:cd06174 234 GGLSVAVAGLLLSLFGLAGALGSLLLGLLSDRLI----GRKPLLLIGLLLMALGLALLLLaPSLLLLLLLLLLLGFGLGG 309
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 7022664  166 YLPLGFEFAVEITYPESEGTSSGLLNASAQIFGILFTLAQGKLTSD-YGPKAGNIFLCVWMFIGIILT 232
Cdd:cd06174 310 LLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAAtFGLTGAFLVLAVLLLLAAILL 377
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
56-241 8.50e-15

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 73.37  E-value: 8.50e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7022664   56 IPFVLLLITYGIMTGAFYSVSTLLNQMILTYYEGEEVNAGRIGLTLVVAGMVGSILCGLWLDYT-KTYKQTTLIVYILSF 134
Cdd:COG2271 180 LRFWLLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLgRRRKLVLAIGLLLAA 259
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7022664  135 IGMVIFTFTLDLRYIIIVFVtggVLGFFMTGYLPLGFEFAVEITYPESEGTSSGLLNASAQIFGILFTLAQGKLTSDYGP 214
Cdd:COG2271 260 LALLLLALLPSPALAIALLF---LAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGYLLDATGY 336
                       170       180
                ....*....|....*....|....*..
gi 7022664  215 KAGNIFLCVWMFIGIILTALIKSDLRR 241
Cdd:COG2271 337 QAAFLLLAALALLAALLALLLLRETRK 363
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
1-242 1.79e-12

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 66.83  E-value: 1.79e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7022664    1 MFYGTSAVATLLFILTAIAFKEKPRYPPSQAQAALqdsppeeysykKSIRNLFKNIPFVLLLITYGIMTGAFYSVSTLLN 80
Cdd:COG2223 161 AFLILGILLLVVAVLAWLFLRDPPAGAAAAAKASL-----------RDQLEALRDPRFWLLSLLYFGTFGSFIGFSSWLP 229
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7022664   81 QMILTYYEGEEVNAGRIGLTLVVAGMVGSILCGLWLDYTKTYKqTTLIVYILSFIGMVIFTFTLDlrYIIIVFVTGGVLG 160
Cdd:COG2223 230 PYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRR-VLLIVFALMALGLLLLALALG--SLWLFLVLFLLLG 306
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7022664  161 FFMTGYLPLGFEFAVEITYPESEGTSSGLLNASAQIFGILFTLAQGKLTSDYG-PKAGNIFLCVWMFIGIILTALIKSDL 239
Cdd:COG2223 307 LALGGGNGAVFALVPDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGALLDATGsYTAAFLVFAVLALVALVLTLLLYRRP 386

                ...
gi 7022664  240 RRH 242
Cdd:COG2223 387 RRA 389
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
1-169 1.21e-09

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 58.37  E-value: 1.21e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7022664    1 MFYGTSAVATLLFILTAIAFKEKPRyppsqaqaalqdSPPEEYSYKKSIRNLFKNIPFVLLLITYGIMTGAFYSVSTLLN 80
Cdd:COG2211 185 TALIFAVLGLLAFLLTFFGTKERPV------------PEEEKVSLKESLKALLKNRPFLLLLLAYLLFFLALALVAALLL 252
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7022664   81 QMILTYYEGEEVNAGRIGLTLVVAGMVGSILCGLWLDYTKTyKQTTLIVYILSFIGMVIFTFtLDLRYIIIVFVTGGVLG 160
Cdd:COG2211 253 YYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGK-KKAFIIGLLLAALGLLLLFF-LGPGNLWLLLVLAALAG 330

                ....*....
gi 7022664  161 FFMTGYLPL 169
Cdd:COG2211 331 IGLGAILVL 339
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
1-200 2.63e-09

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 56.91  E-value: 2.63e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7022664    1 MFYGTSAVATLLFILTAIAFKEkpryppsqaqaalqDSPPEEYSYKKSIRNLFKNIPFVLLLITYGIMTGAFYSVSTLLN 80
Cdd:COG2814 166 VFLVNAVLALLALLLLLRLLPE--------------SRPAARARLRGSLRELLRRPRLLLLLLLAFLLGFGFFALFTYLP 231
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7022664   81 QMILTYYEGEEVNAGRIGLTLVVAGMVGSILCGLWLDYTKtYKQTTLIVYILSFIGMVIFTFTLDLRYIIIVFVtggVLG 160
Cdd:COG2814 232 LYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFG-RRRLLLIGLLLLALGLLLLALAGSLWLLLLALF---LLG 307
                       170       180       190       200
                ....*....|....*....|....*....|....*....|
gi 7022664  161 FFMTGYLPLGFEFAVEITYPESEGTSSGLLNASAQIFGIL 200
Cdd:COG2814 308 FGFGLLFPLLQALVAELAPPEARGRASGLYNSAFFLGGPL 347
MFS_MT3072_like cd17475
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ...
3-233 1.96e-08

Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341028 [Multi-domain]  Cd Length: 378  Bit Score: 54.55  E-value: 1.96e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7022664    3 YGTSAVATLLFILTAIAFKEKPRYPPSQAQAALQDSppeeysykKSIRNLFKNIPFVLLLITYGIMTGAFYSVSTLLnqm 82
Cdd:cd17475 153 FVVAGLVSILAAVLFWLFYREPPAASAATESASTLL--------RSLKEVLRNRDVWLIAIAGALLVAPQFALLTFL--- 221
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7022664   83 ILTYYEGEEVNAGRIGLTLVVA---GMVGSILCGLWLDYT-----KTYKQTTLIVYILSFIGMVIFTFTLDLRYIIIVFV 154
Cdd:cd17475 222 LLFLHDHLGLSVVAAGALLAVAqlgGALGRIGLGRVSDRVfggrrRPVLVITAAIAAAALLVLSLLSPGTPLWLLVLLLI 301
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7022664  155 tggVLGFFMTGYLPLGFEFAVEITYPESEGTSSGLLNASAQIFGILFTLAQGKL---TSDYGPkaGNIFLCVWMFIGIIL 231
Cdd:cd17475 302 ---LLGLFAIGWNGLYLTLVAESAGPEQAGTALGLANTINFIGIAIGPPLFGLLvdaTHSYAP--AWLALALLLVLAALL 376

                ..
gi 7022664  232 TA 233
Cdd:cd17475 377 LL 378
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
1-236 2.58e-06

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 47.96  E-value: 2.58e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7022664    1 MFYGTSAVATLLFILTAIAFKEKPRYPPSQAQAALQDsppeeysyKKSIRNLFKNIPFVLLLITYGIMTGAFYSVSTLLn 80
Cdd:cd17325 152 PFLVCAALALLALVLALLLLPEPRPPPNKRAVSAARL--------RSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFL- 222
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7022664   81 qmILTYYEGEEVNAGRIGLTL---VVAGMVGSILCGlWLDYTKTYKQTTLIVYILSFIGMVIFTFTLDLRYIIIVFVtgg 157
Cdd:cd17325 223 --PLYAAELGGLSPAQIGLLFgaqGLASALSQPPAG-KLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLA--- 296
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 7022664  158 VLGFFMTGYLPLGFEFAVEITYPESEGTSSGLLNASAQIFGILFTLAQGKLTSDYGPKAGNIFLCVWMFIGIILTALIK 236
Cdd:cd17325 297 LLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLLLR 375
MFS_1 pfam07690
Major Facilitator Superfamily;
7-202 2.84e-05

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 44.72  E-value: 2.84e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7022664      7 AVATLLFILTAIAFKEKPRYPPSQAQAALQDSPPEEYSYKKSIRNLfkniPFVLLLITYGIMTGAFYSVSTLLNQMILTY 86
Cdd:pfam07690 155 LILAILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIVAWKALLRD----PVLWLLLALLLFGFAFFGLLTYLPLYQEVL 230
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7022664     87 YEGEEVNAGRIGLtLVVAGMVGSILCGLWLDYTKTYKQTTLIV--YILSFIGMVIFTFTLDLRYIIIVFVtggVLGFFMT 164
Cdd:pfam07690 231 GLSALLAGLLLGL-GGLLGAIGRLLLGRLSDRLGRRRRLLLALllLILAALGLLLLSLTLSSLWLLLALL---LLGFGFG 306
                         170       180       190
                  ....*....|....*....|....*....|....*...
gi 7022664    165 GYLPLGFEFAVEITYPESEGTSSGLLNASAQIFGILFT 202
Cdd:pfam07690 307 LVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALGP 344
MFS_SLC45_SUC cd17313
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ...
1-231 3.02e-05

Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340871 [Multi-domain]  Cd Length: 421  Bit Score: 44.93  E-value: 3.02e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7022664    1 MFYGTSAVATLLFILTAIAFKEKPRYPPSQAQAALQDSPPEEYSYKKSIRNLFKNIPFVLLLITYGIMtgAFYSVSTLLN 80
Cdd:cd17313 181 PFYIGAIILLVCVLVTLFFVKEPPLSPEAGEHSENPSLGEVLKSLLKLLKIMPRSLLRLLLVIFFWWI--AFFPFELFFT 258
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7022664   81 Q-MILTYYEG---------EEVNAGRIGLTLV-VAGMVGSILCGLWLDYTKTyKQTTLIVYILSFIGMVIFTFTLDLRYI 149
Cdd:cd17313 259 DyMGEEVYHGtsaasshygAGVRMGAWGLLIFsLAFLIFSLPIGKLGKKIGR-KKVYLIGLVLFAVGMALMALVHNVTVA 337
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7022664  150 IIVFVTGGVlGFFMTGYLPlgFEFAVEIT--YPESEGTSSGLLNASAQIFGILFTLAQGKLTSDYGPKAGNIFLCVWMFI 227
Cdd:cd17313 338 LVLFALGGI-GWATININP--YPLVSDYHseSGRGQGTDTGLLNLAISLAQILVSLLAGPIIDVKGYGTVFPVAAVASFL 414

                ....
gi 7022664  228 GIIL 231
Cdd:cd17313 415 SLVG 418
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
2-233 4.00e-05

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 44.46  E-value: 4.00e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7022664    2 FYGTSAVATLLFILTAIAFkekpryPPSQAQAALQdsppeeYSYKKSIRNLFKNIPFVLLLITYGIMTGAFYSVSTLLNQ 81
Cdd:cd17324 156 FLAIAVLALLAALLLWRLL------PSLPPKKPGS------LGLLSSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAP 223
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7022664   82 MILtyyEGEEVNAGRIGLTLV---VAGMVGSILCGLWLDytKTYKQTTLIVYILSFIGMVIFTFTldLRYIIIVFVTGGV 158
Cdd:cd17324 224 FLT---DVPGFSSSAIIGLLLlfgVAGVVGSPLAGRLAD--RGGRRALLIALLLLAAALLLLTLL--GPSPLLLLVGLVL 296
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 7022664  159 LGFFMTGYLPLGFEFAVEITyPESEGTSSGLLNASAQIFGILFTLAQGKLTSDYGPKAGNIFLCVWMFIGIILTA 233
Cdd:cd17324 297 WGLGFFAAHSALQTRVLRLA-PEARGLASSLYLAAYNLGGALGAALGGLVLDHGGWAGVGWVGAALLLLALLLAL 370
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
2-233 8.04e-05

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 43.31  E-value: 8.04e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7022664    2 FYGTSAVATLLFILTAIAFKekPRYPPSQAQAALQDSPPEEYSYKKSIRNlfkniPFVLLLITYGIMTGAFYSVSTLLNQ 81
Cdd:cd17478 148 GLGLLILLIIPGLAVALLLL--RLRPLKKPEAKKAAAKSSARSTLKGVWR-----ALLLLLIIVFLRSWVLSSLTTFLPF 220
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7022664   82 MiLTYYEGEEVNAGRIGLTLVVAGMVGSILCGLWLDYtktYKQTTLIvyILSFIGMVIFTFTLDLRYIIIVFVTGGVLGF 161
Cdd:cd17478 221 Y-LVQRGYSLVFAGLLLSLFLFAGAIGTLIGGPLSDR---FGRRRVI--IASLLLAAPFLLLFLLTPGIWSYILLVLAGF 294
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 7022664  162 FMTGYLPLGFEFAVEITyPESEGTSSGLLNASAQIFGILFTLAQGKLTSDYGPKAGNIFLCVWMFIGIILTA 233
Cdd:cd17478 295 LLFASFPVTVVLAQELL-PGNVGLASGLMMGLSFGLGGIGAPVLGALADAFGLESVLLILALLPLLGALLAF 365
MFS_YcxA_like cd17355
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ...
7-234 2.56e-04

MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340913 [Multi-domain]  Cd Length: 386  Bit Score: 41.87  E-value: 2.56e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7022664    7 AVATLLFILTAIAFKEKPRYPPSQAQAAlqDSPPEEYSYKKSIRNLFKNIPFVLLLITYGIMTGAFYSVSTLLNQMILTY 86
Cdd:cd17355 163 VLALLALLVLVPVLLLLRRRPADLALRA--YDDASPASPGSTLKEALRSASFWLLALAFFLCGFAVVGLIVHLVPYLADR 240
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7022664   87 YEGEEVNAGRIGLtLVVAGMVGSILCGLWLD-YTKTYkqTTLIVYILSFIGMVIFTFTLDLRYIIIVFVtgGVLGFFMTG 165
Cdd:cd17355 241 GISPAAAAVALAL-IGLFNIVGRLLSGWLGDrYSPRR--LLAASYALRALGLALLLLLPFPPLALLLFA--ALFGLGWGA 315
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 7022664  166 YLPLGFEFAVEITYPESEGTSSGLLNASAQIFGILFTLAQGKLTSDYGPKAGNIFLCVWMFIGIILTAL 234
Cdd:cd17355 316 TVPLTAALAARYFGARSYGTLFGLVFAPHQLGSALGPWLGGLLYDRTGSYTAAWALAVALGLIAALLVL 384
MFS_TRI12_like cd06179
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ...
52-202 2.60e-04

Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340868 [Multi-domain]  Cd Length: 518  Bit Score: 42.23  E-value: 2.60e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7022664   52 LFKNIPFVLLLITYGIMTGAFYSVSTLLNQMILTYYEGEEVNAGRIGLTLVVAGMVGSILCGLWLDYTKTYKqTTLIVYI 131
Cdd:cd06179 258 LFRGRNFALILIVAFVEGMIFYSLNIFWPQQISLLFTTDPLKAGLYQLPFGLGTLFGAILAGLLLTKIKHIK-WQLVAGF 336
                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 7022664  132 LSFIGMVIFTFTLD----LRYIIIVFVTGGVLGFFMTgylpLGFEFAVEITYPESEGTSSGLLNASAQIFGILFT 202
Cdd:cd06179 337 VLFTAFLALLALITpdnkALAIAFSVLAGIGIGGPLV----LAIVIVQLSVPPEDIGTASGLLGSARALGGAVGT 407
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
58-234 3.17e-04

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 41.43  E-value: 3.17e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7022664   58 FVLLLITYGIMTGAFYSVSTLLNQMILTYYEGEEVNAGRIGLTLVVAGMVGSILCGLWLDYTkTYKQTTLIVYILSFIGM 137
Cdd:cd17316 179 TLLLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRI-GRKKTLVIGLILSGILA 257
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7022664  138 VIFTFTLDLrYIIIVFVTGGVLGFFMTGYLPLGFEFAVEITYPESEGTSSGLLNASAQIFGILFTLAQGKLTSDYGPKAG 217
Cdd:cd17316 258 LPLFYLLSG-SPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGTGV 336
                       170
                ....*....|....*..
gi 7022664  218 NIFLCVWMFIGIILTAL 234
Cdd:cd17316 337 PALILALLAIVALIVAL 353
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
103-235 4.55e-04

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 41.02  E-value: 4.55e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7022664  103 VAGMVGSILCGLWLDYTKTYKQTTLIVYILSF-IGMVIFTFTLDLRYIIIVFVTGGvlGFFMTGYLPLGFEFAVEITYPE 181
Cdd:cd17319 226 LAGAIGMILGGRLSDRLLRGARRLVIIIGLLLaAVGLLLAYLTTSPVVAVILLSLA--GFGIGAASPVFWSLPADLLPGE 303
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 7022664  182 SEGTSSGLLNASAQIFGILFTLAQGKL-TSDYGPKAGNIFLCVWMFIGIILTALI 235
Cdd:cd17319 304 AAATAGGLINSGGNLGGFVAPLLIGYLvDATGSYTAAFLFLAAVALLAALLVLLL 358
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
1-211 5.21e-04

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 41.02  E-value: 5.21e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7022664    1 MFYGTSAVATLLFILTAIAFKEKPRYppsqaqaalQDSPPEEYSYKKSIRNLFKNIPFVLLLITYGIMTGAFYSVSTLLN 80
Cdd:cd17320 155 IFVFLALLGLLLLLLVLLFLPETLPE---------EKRKPLLSSLLRAYKRVLKNRRFLGYALALGLSFAGLFAYLAAAP 225
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7022664   81 QMILTYYEGEEVNAGRIGLTLVVAGMVGSILCGLWLDYTKTYKQTTLIVYILSFIGMVIFTFTLDLRYIIIVFVTGGVLG 160
Cdd:cd17320 226 FIYIEQLGLSPAQFGLLFALNAIALILGSLLNGRLVRRFGPRRLLRLGLLLLLAAALVLLLAALLGGLSLWPLVAPLFLI 305
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|..
gi 7022664  161 FFMTGYL-PLGFEFAVEItYPESEGTSSGLLNASAQIFGILFTLAQGKLTSD 211
Cdd:cd17320 306 FFGFGLIfPNATSLALEP-FPHVAGTASALLGFLQFLIGALAGALVGLLPNG 356
2A0104 TIGR00881
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ...
103-213 3.86e-03

phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273319 [Multi-domain]  Cd Length: 379  Bit Score: 38.13  E-value: 3.86e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7022664    103 VAGMVGSILCGlWL---DYTKTYKQTTLIVYILSFIGMVIFTFTLDLRYIIIVfVTGGVLGFFMTGYLPLGFEFAVEITY 179
Cdd:TIGR00881 263 LGGLVGTLLAG-WLsdkLFNGRRGPLAVFFMALIIVSLLVYWLNPAANPLMDL-ICLFALGFLVYGPQMLIGVIASELAP 340
                          90       100       110
                  ....*....|....*....|....*....|....
gi 7022664    180 PESEGTSSGLLNASAQIFGILFTLAQGKLTSDYG 213
Cdd:TIGR00881 341 KKAAGTAAGFVGFFAYLGGILAGLPLGYLADGFG 374
MFS_MelB_like cd17332
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ...
6-171 4.47e-03

Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340890 [Multi-domain]  Cd Length: 424  Bit Score: 37.97  E-value: 4.47e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7022664    6 SAVATLLFILTAIAFKEKPRYPPSqaqaalqdsPPEEYSYKKSIRNLFKNIPFVLLLITYGIMTGAFYSVSTLLNqMILT 85
Cdd:cd17332 180 GIIGIILLLICFFGTRERVVPPEE---------EKSKLPLLKSLKALLKNRPFLILLLAYLLYFLAFNIVNTVLV-YYFK 249
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7022664   86 YYEGEEVNAGRIGLTLVVAGMVGSILCGL---WLDYTKTYKqTTLIVYILSFIGMviftFTLDLRYIIIVFVTGGVLGFF 162
Cdd:cd17332 250 YVLGGRAELVLLLLLILSGALLALLPWPPlkkRFGKKKAFF-IGLLLAILGLLLL----FFLPPGNLVLILVLAVLAGIG 324

                ....*....
gi 7022664  163 MTGYLPLGF 171
Cdd:cd17332 325 YGGANLLPW 333
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
57-196 5.02e-03

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 37.92  E-value: 5.02e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7022664   57 PFVLLLITYGIMTGAFYSVSTLLNQMILTYYEGEEVNAGRIGLTLVVAGMVGSILCGLWLDyTKTYKQTTLIVYILSFIG 136
Cdd:cd17321 169 TFSGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLAD-RFGPRLVLVAGLLLTAVG 247
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 7022664  137 MVIFTFTLDLRYIIIVFVTGGVLGFFMTGYLPLGFEFAVEITYPESEGTSSGLLNASAQI 196
Cdd:cd17321 248 LLLLALLGADSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQL 307
MFS_MCT_SLC16 cd17352
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ...
52-235 6.57e-03

Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340910 [Multi-domain]  Cd Length: 361  Bit Score: 37.53  E-value: 6.57e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7022664   52 LFKNIPFVLLLITYGIMTGAFYSVSTLLnqmiLTYYEGEEVNAGRIGLTLV---VAGMVGSILCGLWLDYTKTYKQTTLI 128
Cdd:cd17352 179 LLKDPTFVLLALGVSFAMLGFFVPFVYL----PSYAKSLGIDESDAAFLLSiigISDIVGRILLGLLADKPRIGRLYLYI 254
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7022664  129 VYILsFIGMVIFTFTLDLRYIIIVFVtGGVLGFFMTGYLPLGFEFAVEITYPESEGTSSGLLNASAQIFGILFTLAQGKL 208
Cdd:cd17352 255 FTLL-ILGLSLLAFPLATTYVGLIVF-SVLFGFCSGSYSSLTPVILADLVGLEKLSNAYGLVLLFQGLAALVGPPIAGLL 332
                       170       180
                ....*....|....*....|....*...
gi 7022664  209 TSDYGP-KAGNIFLCVWMFIGIILTALI 235
Cdd:cd17352 333 RDYTGDyDAAFYFCGACLLLSGVLLFLL 360
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
2-235 9.18e-03

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 37.16  E-value: 9.18e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7022664    2 FYGTSAVATLLFILTAIAFKEKPRYPPSQAQAALqdsppeeysykKSIRNLFKNIPFVLLLITYGIMTGAFYSVSTLLNQ 81
Cdd:cd17474 155 FFLLAALIPVAFLAILFLLPEPKEKAKSSSATKL-----------RDLKKALRGRGLLTFLVSAFLYFFLYFAFLTYLPF 223
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7022664   82 MILTYYEGEEVNAGRIGLTLVVAGMVGSILCGLWLDYTKTYKQTTLIVYILSFIGMVIFTFTLDLrYIIIVFVTggVLGF 161
Cdd:cd17474 224 LLELLYGISPIIIGLLFAGWSVLLALGSLFVGRLLKKRFGARRILVIGLLLYALSLLLLGFVPSL-ALLLIAIV--LFGL 300
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 7022664  162 FMTGYLPLGFEFAVEITYPESEGTSSGLLNASAQIFGILFTLAQGKLTSDYGPKAGNIFLCVWMFIGIILTALI 235
Cdd:cd17474 301 GLGLNLPLLTTLVTELAPEEERGTASSLYNFVRFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAVLLALL 374
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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