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Conserved domains on  [gi|7023464|dbj|BAA91972|]
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unnamed protein product [Homo sapiens]

Protein Classification

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List of domain hits

Name Accession Description Interval E-value
Tudor_TDRD4_rpt5 cd20418
fifth Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; ...
487-591 1.48e-67

fifth Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


:

Pssm-ID: 410489  Cd Length: 105  Bit Score: 215.35  E-value: 1.48e-67
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7023464  487 LTDFRTEMPCLAEYDDGLWYRAKIVAIKEFNPLSILVQFVDYGSTAKLTLNRLCQIPSHLMRYPARAIKVLLAGFKPPLR 566
Cdd:cd20418   1 LTDFRPEMPCLAEYSDGKWYRAKLLSILEFNPVKILVRHVDYGSTAALPTSRLRQIPAELMQYPCQAIKVKLAGFKPPLN 80
                        90       100
                ....*....|....*....|....*
gi 7023464  567 DLGETRIPYCPKWSMEALWAMIDCL 591
Cdd:cd20418  81 DSETERIPYCPEWSMKALWAMIDLL 105
Tudor_TDRD4_rpt4 cd20417
fourth Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; ...
281-348 2.65e-42

fourth Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


:

Pssm-ID: 410488  Cd Length: 68  Bit Score: 146.81  E-value: 2.65e-42
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 7023464  281 WKKGEACAVRGSDTLWYRGKVMEVVGGAVRVQYLDHGFTEKIPQCHLYPILLYPDIPQFCIPCQLHNT 348
Cdd:cd20417   1 WKKGEGCVVRGSDTLWYRGKVLEVIGGMVRVQYVDQGYIEKIPQCHLYPMVLYPDIPQFCIPCQLYGT 68
Tudor_TDRD4_rpt3 cd20416
third Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; ...
1-78 2.85e-42

third Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


:

Pssm-ID: 410487  Cd Length: 82  Bit Score: 147.25  E-value: 2.85e-42
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 7023464    1 MIAAYENSKWEPVKWENDMHCAVKIQDKNQWRRGQIIRMVTDTLVEVLLYDVGVELVVNVDCLRKLEENLKTMGRLSL 78
Cdd:cd20416   5 MIAEYENSKPEPVKWENDMHCAVQIQDKKQWRRGQIIRVVSDTLVEVFLYDFGNKEVVNIDCLRKLEENLKTIGKLAL 82
 
Name Accession Description Interval E-value
Tudor_TDRD4_rpt5 cd20418
fifth Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; ...
487-591 1.48e-67

fifth Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410489  Cd Length: 105  Bit Score: 215.35  E-value: 1.48e-67
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7023464  487 LTDFRTEMPCLAEYDDGLWYRAKIVAIKEFNPLSILVQFVDYGSTAKLTLNRLCQIPSHLMRYPARAIKVLLAGFKPPLR 566
Cdd:cd20418   1 LTDFRPEMPCLAEYSDGKWYRAKLLSILEFNPVKILVRHVDYGSTAALPTSRLRQIPAELMQYPCQAIKVKLAGFKPPLN 80
                        90       100
                ....*....|....*....|....*
gi 7023464  567 DLGETRIPYCPKWSMEALWAMIDCL 591
Cdd:cd20418  81 DSETERIPYCPEWSMKALWAMIDLL 105
Tudor_TDRD4_rpt4 cd20417
fourth Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; ...
281-348 2.65e-42

fourth Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410488  Cd Length: 68  Bit Score: 146.81  E-value: 2.65e-42
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 7023464  281 WKKGEACAVRGSDTLWYRGKVMEVVGGAVRVQYLDHGFTEKIPQCHLYPILLYPDIPQFCIPCQLHNT 348
Cdd:cd20417   1 WKKGEGCVVRGSDTLWYRGKVLEVIGGMVRVQYVDQGYIEKIPQCHLYPMVLYPDIPQFCIPCQLYGT 68
Tudor_TDRD4_rpt3 cd20416
third Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; ...
1-78 2.85e-42

third Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410487  Cd Length: 82  Bit Score: 147.25  E-value: 2.85e-42
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 7023464    1 MIAAYENSKWEPVKWENDMHCAVKIQDKNQWRRGQIIRMVTDTLVEVLLYDVGVELVVNVDCLRKLEENLKTMGRLSL 78
Cdd:cd20416   5 MIAEYENSKPEPVKWENDMHCAVQIQDKKQWRRGQIIRVVSDTLVEVFLYDFGNKEVVNIDCLRKLEENLKTIGKLAL 82
TUDOR pfam00567
Tudor domain;
233-347 5.28e-25

Tudor domain;


Pssm-ID: 425754 [Multi-domain]  Cd Length: 117  Bit Score: 100.12  E-value: 5.28e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7023464    233 NVFEATVSCVGDDGTIFVVPKLSEFELIKMTNEIQSNLKCLGLLEPYFWKKGEACAVRGSDTLWYRGKVMEVV-GGAVRV 311
Cdd:pfam00567   1 STIDVVVSHIESPSTFYIQPKSDSKKLEKLTEELQEYYASKPPESLPPAVGDGCVAAFSEDGKWYRAKITESLdDGLVEV 80
                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 7023464    312 QYLDHGFTEKIPQCHLYPILLYPD-IPQFCIPCQLHN 347
Cdd:pfam00567  81 LFIDYGNTETVPLSDLRPLPPELEsLPPQAIKCQLAG 117
TUDOR pfam00567
Tudor domain;
425-560 3.69e-14

Tudor domain;


Pssm-ID: 425754 [Multi-domain]  Cd Length: 117  Bit Score: 69.31  E-value: 3.69e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7023464    425 AVQVKHVVSPNEVYIcldsietsnQSnqhsdtddsgVSGESESESLDEALQRVNKKVEAlPPLTDFRTEMPCLAEYDDGL 504
Cdd:pfam00567   4 DVVVSHIESPSTFYI---------QP----------KSDSKKLEKLTEELQEYYASKPP-ESLPPAVGDGCVAAFSEDGK 63
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 7023464    505 WYRAKIVAIKEfNPLsILVQFVDYGSTAKLTLNRLCQIPSHLMRYPARAIKVLLAG 560
Cdd:pfam00567  64 WYRAKITESLD-DGL-VEVLFIDYGNTETVPLSDLRPLPPELESLPPQAIKCQLAG 117
TUDOR smart00333
Tudor domain; Domain of unknown function present in several RNA-binding proteins. 10 copies in ...
494-546 2.23e-09

Tudor domain; Domain of unknown function present in several RNA-binding proteins. 10 copies in the Drosophila Tudor protein. Initial proposal that the survival motor neuron gene product contain a Tudor domain are corroborated by more recent database search techniques such as PSI-BLAST (unpublished).


Pssm-ID: 197660  Cd Length: 57  Bit Score: 53.43  E-value: 2.23e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 7023464     494 MPCLAEYDDGLWYRAKIVAIKEFNplSILVQFVDYGSTAKLTLNRLCQIPSHL 546
Cdd:smart00333   7 DKVAARWEDGEWYRARIVKVDGEQ--LYEVFFIDYGNEEVVPPSDLRQLPEEL 57
TUDOR smart00333
Tudor domain; Domain of unknown function present in several RNA-binding proteins. 10 copies in ...
281-330 9.49e-09

Tudor domain; Domain of unknown function present in several RNA-binding proteins. 10 copies in the Drosophila Tudor protein. Initial proposal that the survival motor neuron gene product contain a Tudor domain are corroborated by more recent database search techniques such as PSI-BLAST (unpublished).


Pssm-ID: 197660  Cd Length: 57  Bit Score: 51.89  E-value: 9.49e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 7023464     281 WKKGEACAVRGSDTLWYRGKVMEVVG-GAVRVQYLDHGFTEKIPQCHLYPI 330
Cdd:smart00333   3 FKVGDKVAARWEDGEWYRARIVKVDGeQLYEVFFIDYGNEEVVPPSDLRQL 53
TUDOR pfam00567
Tudor domain;
21-82 3.68e-06

Tudor domain;


Pssm-ID: 425754 [Multi-domain]  Cd Length: 117  Bit Score: 46.19  E-value: 3.68e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 7023464     21 CAVKIQDKNQWRRGQIIRMVTDTLVEVLLYDVGVELVVNVDCLRKLEENLKTMGRLSLECSL 82
Cdd:pfam00567  54 CVAAFSEDGKWYRAKITESLDDGLVEVLFIDYGNTETVPLSDLRPLPPELESLPPQAIKCQL 115
TUDOR smart00333
Tudor domain; Domain of unknown function present in several RNA-binding proteins. 10 copies in ...
12-68 8.56e-06

Tudor domain; Domain of unknown function present in several RNA-binding proteins. 10 copies in the Drosophila Tudor protein. Initial proposal that the survival motor neuron gene product contain a Tudor domain are corroborated by more recent database search techniques such as PSI-BLAST (unpublished).


Pssm-ID: 197660  Cd Length: 57  Bit Score: 43.42  E-value: 8.56e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 7023464      12 PVKWENDMhCAVKIQDkNQWRRGQIIRMVTDTLVEVLLYDVGVELVVNVDCLRKLEE 68
Cdd:smart00333   1 PTFKVGDK-VAARWED-GEWYRARIVKVDGEQLYEVFFIDYGNEEVVPPSDLRQLPE 55
 
Name Accession Description Interval E-value
Tudor_TDRD4_rpt5 cd20418
fifth Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; ...
487-591 1.48e-67

fifth Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410489  Cd Length: 105  Bit Score: 215.35  E-value: 1.48e-67
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7023464  487 LTDFRTEMPCLAEYDDGLWYRAKIVAIKEFNPLSILVQFVDYGSTAKLTLNRLCQIPSHLMRYPARAIKVLLAGFKPPLR 566
Cdd:cd20418   1 LTDFRPEMPCLAEYSDGKWYRAKLLSILEFNPVKILVRHVDYGSTAALPTSRLRQIPAELMQYPCQAIKVKLAGFKPPLN 80
                        90       100
                ....*....|....*....|....*
gi 7023464  567 DLGETRIPYCPKWSMEALWAMIDCL 591
Cdd:cd20418  81 DSETERIPYCPEWSMKALWAMIDLL 105
Tudor_TDRD4_rpt4 cd20417
fourth Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; ...
281-348 2.65e-42

fourth Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410488  Cd Length: 68  Bit Score: 146.81  E-value: 2.65e-42
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 7023464  281 WKKGEACAVRGSDTLWYRGKVMEVVGGAVRVQYLDHGFTEKIPQCHLYPILLYPDIPQFCIPCQLHNT 348
Cdd:cd20417   1 WKKGEGCVVRGSDTLWYRGKVLEVIGGMVRVQYVDQGYIEKIPQCHLYPMVLYPDIPQFCIPCQLYGT 68
Tudor_TDRD4_rpt3 cd20416
third Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; ...
1-78 2.85e-42

third Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410487  Cd Length: 82  Bit Score: 147.25  E-value: 2.85e-42
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 7023464    1 MIAAYENSKWEPVKWENDMHCAVKIQDKNQWRRGQIIRMVTDTLVEVLLYDVGVELVVNVDCLRKLEENLKTMGRLSL 78
Cdd:cd20416   5 MIAEYENSKPEPVKWENDMHCAVQIQDKKQWRRGQIIRVVSDTLVEVFLYDFGNKEVVNIDCLRKLEENLKTIGKLAL 82
TUDOR pfam00567
Tudor domain;
233-347 5.28e-25

Tudor domain;


Pssm-ID: 425754 [Multi-domain]  Cd Length: 117  Bit Score: 100.12  E-value: 5.28e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7023464    233 NVFEATVSCVGDDGTIFVVPKLSEFELIKMTNEIQSNLKCLGLLEPYFWKKGEACAVRGSDTLWYRGKVMEVV-GGAVRV 311
Cdd:pfam00567   1 STIDVVVSHIESPSTFYIQPKSDSKKLEKLTEELQEYYASKPPESLPPAVGDGCVAAFSEDGKWYRAKITESLdDGLVEV 80
                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 7023464    312 QYLDHGFTEKIPQCHLYPILLYPD-IPQFCIPCQLHN 347
Cdd:pfam00567  81 LFIDYGNTETVPLSDLRPLPPELEsLPPQAIKCQLAG 117
TUDOR pfam00567
Tudor domain;
425-560 3.69e-14

Tudor domain;


Pssm-ID: 425754 [Multi-domain]  Cd Length: 117  Bit Score: 69.31  E-value: 3.69e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7023464    425 AVQVKHVVSPNEVYIcldsietsnQSnqhsdtddsgVSGESESESLDEALQRVNKKVEAlPPLTDFRTEMPCLAEYDDGL 504
Cdd:pfam00567   4 DVVVSHIESPSTFYI---------QP----------KSDSKKLEKLTEELQEYYASKPP-ESLPPAVGDGCVAAFSEDGK 63
                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 7023464    505 WYRAKIVAIKEfNPLsILVQFVDYGSTAKLTLNRLCQIPSHLMRYPARAIKVLLAG 560
Cdd:pfam00567  64 WYRAKITESLD-DGL-VEVLFIDYGNTETVPLSDLRPLPPELESLPPQAIKCQLAG 117
Tudor_TDRD12_rpt2 cd20435
second Tudor domain found in Tudor domain-containing protein 12 (TDRD12) and similar proteins; ...
496-567 3.93e-12

second Tudor domain found in Tudor domain-containing protein 12 (TDRD12) and similar proteins; TDRD12, also called ES cell-associated transcript 8 protein (ECAT8), is a putative ATP-dependent DEAD-like RNA helicase that is essential for germ cell development and maintenance. It acts as a unique piRNA biogenesis factor essential for secondary PIWI interacting RNA (piRNA) biogenesis. TDRD12 contains two Tudor domains, one at the N-terminus and the other at the C-terminal end. The model corresponds to the second/C-terminal one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410506  Cd Length: 134  Bit Score: 63.81  E-value: 3.93e-12
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 7023464  496 CLAEYDDGLWYRAKIVAIKEFN----PLSILVQFVDYGSTAKLTLNRLCQIPSHLMRYPARAIKVLLAGFKPPLRD 567
Cdd:cd20435  56 CAVEDENNLYHRVKVLEITEKDdktkPREVLVKFIDEGRVETVVVSQLLELPEELKSLPPQAVEVFLCNVKPVDND 131
Tudor_TDRD4_rpt2 cd20415
second Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; ...
496-563 1.86e-09

second Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410486  Cd Length: 96  Bit Score: 55.13  E-value: 1.86e-09
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 7023464  496 CLAEYDDGLWYRAKIVAIKEFNplSILVQFVDYGSTAKLTLNRLCQIPSHLMRYPARAIKVLLAGFKP 563
Cdd:cd20415  31 CVALFEDGAWYRARIIGLPGHR--EVEVKYVDFGNTATVTIKHVRKIKDDFLSLPEKARECRLAFIEP 96
TUDOR smart00333
Tudor domain; Domain of unknown function present in several RNA-binding proteins. 10 copies in ...
494-546 2.23e-09

Tudor domain; Domain of unknown function present in several RNA-binding proteins. 10 copies in the Drosophila Tudor protein. Initial proposal that the survival motor neuron gene product contain a Tudor domain are corroborated by more recent database search techniques such as PSI-BLAST (unpublished).


Pssm-ID: 197660  Cd Length: 57  Bit Score: 53.43  E-value: 2.23e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 7023464     494 MPCLAEYDDGLWYRAKIVAIKEFNplSILVQFVDYGSTAKLTLNRLCQIPSHL 546
Cdd:smart00333   7 DKVAARWEDGEWYRARIVKVDGEQ--LYEVFFIDYGNEEVVPPSDLRQLPEEL 57
Tudor_dTUD-like cd20379
Tudor domain found in Drosophila melanogaster maternal protein Tudor (dTUD) and similar ...
283-330 3.31e-09

Tudor domain found in Drosophila melanogaster maternal protein Tudor (dTUD) and similar proteins; dTUD is required during oogenesis for the formation of primordial germ cells and for normal abdominal segmentation. It contains 11 Tudor domains. The family also includes mitochondrial A-kinase anchor protein 1 (AKAP1) and Tudor domain-containing proteins (TDRDs). AKAP1, also called A-kinase anchor protein 149 kDa (AKAP 149), or dual specificity A-kinase-anchoring protein 1 (D-AKAP-1), or protein kinase A-anchoring protein 1 (PRKA1), or Spermatid A-kinase anchor protein 84 (S-AKAP84), is found in mitochondria and in the endoplasmic reticulum-nuclear envelope where it anchors protein kinases, phosphatases, and a phosphodiesterase. It regulates multiple cellular processes governing mitochondrial homeostasis and cell viability. AKAP1 binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane. TDRDs have diverse biological functions and may contain one or more copies of the Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410450  Cd Length: 50  Bit Score: 52.90  E-value: 3.31e-09
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|
gi 7023464  283 KGEACAVRGSDT-LWYRGKVMEVV-GGAVRVQYLDHGFTEKIPQCHLYPI 330
Cdd:cd20379   1 VGDLCAAKYEEDgKWYRARVLEVLsNDKVEVFFVDYGNTETVPLSDLRPL 50
Tudor_TDRD15_rpt5 cd20440
fifth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; ...
419-558 5.43e-09

fifth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410511  Cd Length: 127  Bit Score: 54.77  E-value: 5.43e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7023464  419 SPGELYAVQVKHVVSPNEVYICLDSietsnqsnqhsdtddsgvsgesESESLDEALQRVNKKVEALP-PLTDFRTEMPCL 497
Cdd:cd20440   7 KVGSEEEVYITHVYSPAKFYCQLDR----------------------NTEILEALMEKIAEISKLFNsQILDNCKTRLCL 64
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 7023464  498 AEY-DDGLWYRAKIVAIKefNPLSILVQFVDYGSTAKLTLNRLCQIPSH---LMRYPARAIKVLL 558
Cdd:cd20440  65 AKYfEDGQWYRALAHPVE--SSSHLSVYFVDYGNKQIVEKNEVLPIPDTavdLLLTPMQAIKCCL 127
Tudor_dTUD-like cd20379
Tudor domain found in Drosophila melanogaster maternal protein Tudor (dTUD) and similar ...
494-542 6.38e-09

Tudor domain found in Drosophila melanogaster maternal protein Tudor (dTUD) and similar proteins; dTUD is required during oogenesis for the formation of primordial germ cells and for normal abdominal segmentation. It contains 11 Tudor domains. The family also includes mitochondrial A-kinase anchor protein 1 (AKAP1) and Tudor domain-containing proteins (TDRDs). AKAP1, also called A-kinase anchor protein 149 kDa (AKAP 149), or dual specificity A-kinase-anchoring protein 1 (D-AKAP-1), or protein kinase A-anchoring protein 1 (PRKA1), or Spermatid A-kinase anchor protein 84 (S-AKAP84), is found in mitochondria and in the endoplasmic reticulum-nuclear envelope where it anchors protein kinases, phosphatases, and a phosphodiesterase. It regulates multiple cellular processes governing mitochondrial homeostasis and cell viability. AKAP1 binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane. TDRDs have diverse biological functions and may contain one or more copies of the Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410450  Cd Length: 50  Bit Score: 52.13  E-value: 6.38e-09
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|
gi 7023464  494 MPCLAEY-DDGLWYRAKIVAIKEFNplSILVQFVDYGSTAKLTLNRLCQI 542
Cdd:cd20379   3 DLCAAKYeEDGKWYRARVLEVLSND--KVEVFFVDYGNTETVPLSDLRPL 50
Tudor_dTUD-like cd20379
Tudor domain found in Drosophila melanogaster maternal protein Tudor (dTUD) and similar ...
18-66 6.77e-09

Tudor domain found in Drosophila melanogaster maternal protein Tudor (dTUD) and similar proteins; dTUD is required during oogenesis for the formation of primordial germ cells and for normal abdominal segmentation. It contains 11 Tudor domains. The family also includes mitochondrial A-kinase anchor protein 1 (AKAP1) and Tudor domain-containing proteins (TDRDs). AKAP1, also called A-kinase anchor protein 149 kDa (AKAP 149), or dual specificity A-kinase-anchoring protein 1 (D-AKAP-1), or protein kinase A-anchoring protein 1 (PRKA1), or Spermatid A-kinase anchor protein 84 (S-AKAP84), is found in mitochondria and in the endoplasmic reticulum-nuclear envelope where it anchors protein kinases, phosphatases, and a phosphodiesterase. It regulates multiple cellular processes governing mitochondrial homeostasis and cell viability. AKAP1 binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane. TDRDs have diverse biological functions and may contain one or more copies of the Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410450  Cd Length: 50  Bit Score: 52.13  E-value: 6.77e-09
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*....
gi 7023464   18 DMHCAVKIQDKNQWRRGQIIRMVTDTLVEVLLYDVGVELVVNVDCLRKL 66
Cdd:cd20379   2 GDLCAAKYEEDGKWYRARVLEVLSNDKVEVFFVDYGNTETVPLSDLRPL 50
TUDOR smart00333
Tudor domain; Domain of unknown function present in several RNA-binding proteins. 10 copies in ...
281-330 9.49e-09

Tudor domain; Domain of unknown function present in several RNA-binding proteins. 10 copies in the Drosophila Tudor protein. Initial proposal that the survival motor neuron gene product contain a Tudor domain are corroborated by more recent database search techniques such as PSI-BLAST (unpublished).


Pssm-ID: 197660  Cd Length: 57  Bit Score: 51.89  E-value: 9.49e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 7023464     281 WKKGEACAVRGSDTLWYRGKVMEVVG-GAVRVQYLDHGFTEKIPQCHLYPI 330
Cdd:smart00333   3 FKVGDKVAARWEDGEWYRARIVKVDGeQLYEVFFIDYGNEEVVPPSDLRQL 53
Tudor_TDRD6_rpt4 cd20423
fourth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; ...
489-564 1.65e-08

fourth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410494  Cd Length: 80  Bit Score: 51.71  E-value: 1.65e-08
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 7023464  489 DFRTEMPCLAEY-DDGLWYRAKIVAIKEfNPLSILVQFVDYGSTAKLTLNRLCQIPSHLMRYPARAIKVLLAGFKPP 564
Cdd:cd20423   2 HSLPNPVCLAKYsEDGKWCRALIDNVYE-PVEMVEVTYVDYGNKELVSLKNLRSISEEFLKLKAQAFRCSLYNLIQP 77
Tudor_AKAP1 cd20407
Tudor domain found in mitochondrial A-kinase anchor protein 1 (AKAP1) and similar proteins; ...
496-563 6.58e-08

Tudor domain found in mitochondrial A-kinase anchor protein 1 (AKAP1) and similar proteins; AKAP1, also called A-kinase anchor protein 149 kDa (AKAP 149), dual specificity A-kinase-anchoring protein 1 (D-AKAP-1), protein kinase A-anchoring protein 1 (PRKA1), or Spermatid A-kinase anchor protein 84 (S-AKAP84), is found in mitochondria and in the endoplasmic reticulum-nuclear envelope, where it anchors protein kinases, phosphatases, and a phosphodiesterase. It regulates multiple cellular processes governing mitochondrial homeostasis and cell viability. AKAP1 binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane. It contains a C-terminal Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410478  Cd Length: 76  Bit Score: 49.90  E-value: 6.58e-08
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 7023464  496 CLAEYDDGlWYRAKIVAIKEfNPLSILVQFVDYGSTAKLTLNRLCQIPSHLMRYPARAIKVLLAGFKP 563
Cdd:cd20407  11 CAAPVMNA-WYRAQVVGVFE-ETDEVEIKYLDYGGYERVPVDDLRQIRSDFMTLPFQATECYLANIEP 76
Tudor_TDRD1_rpt1 cd20408
first Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; ...
258-360 8.39e-08

first Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410479  Cd Length: 130  Bit Score: 51.22  E-value: 8.39e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7023464  258 ELIKMTNEIQSNLKCLGLLEPYFWKKGEACAVRGS-DTLWYRGKVMEV--VGGAVRVQYLDHGFTEKIPQCHLYPilLYP 334
Cdd:cd20408  24 SLVKLTSQLKKTYASVNNHKEYIPEVGEVCVAKYSeDQNWYRALVQTVdvQQKKAGVFYIDYGNEETVPLNRIQP--LKK 101
                        90       100
                ....*....|....*....|....*....
gi 7023464  335 DIPQFC---IPCQLHNTTPVGNVWQPDAI 360
Cdd:cd20408 102 DIELFPpcaIKCCLANVKPPSGSWSEECI 130
Tudor_TDRD6_rpt6 cd20425
sixth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; ...
426-554 1.39e-07

sixth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the sixth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410496  Cd Length: 115  Bit Score: 50.15  E-value: 1.39e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7023464  426 VQVKHVVSPNEVYICLDSietsnqsnqhsdtDDSGVSgeSESESLDEALQRVNKKVEALPPLTDfrteMPClAEY-DDGL 504
Cdd:cd20425   4 VYVSHVNSPSDFYVQLAQ-------------DEDELS--MISEKLNASKANDEEVECESLQLGD----LIC-AEYpEDGL 63
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 7023464  505 WYRAkIVAIKEFNPLsILVQFVDYGSTAKLTLNRLCQIPSHLMRYPARAI 554
Cdd:cd20425  64 WYRA-VVKEKIPNNL-VSVQFIDYGNTSVVQPSKIHRLPKELLSIPALSI 111
Tudor_TDRD6_rpt7 cd20426
seventh Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; ...
495-561 1.53e-07

seventh Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the seventh one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410497  Cd Length: 140  Bit Score: 50.96  E-value: 1.53e-07
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 7023464  495 PCLAEY-DDGLWYRAKIVAIKEfNPLSilVQFVDYGSTAKLTLNRLCQIPSHLMRYPARAIKVLLAGF 561
Cdd:cd20426  52 PCIVKYsEDNHWYRALVTKIND-NLVS--VRFVDYGNEEDVVREQVRALPSELLKIPVQAFPCCLSGF 116
Tudor_TDRD11 cd20433
Tudor domain found in Tudor domain-containing protein 11 (TDRD11) and similar proteins; TDRD11, ...
467-547 1.72e-07

Tudor domain found in Tudor domain-containing protein 11 (TDRD11) and similar proteins; TDRD11, also called Staphylococcal nuclease domain-containing protein 1 (SND1), 100 kDa coactivator, EBNA2 coactivator p100, or p100 co-activator, is a multifunctional protein that is reportedly associated with different types of RNA molecules, including mRNA, miRNA, pre-miRNA, and dsRNA. It has been implicated in a number of biological processes in eukaryotic cells, including the cell cycle, DNA damage repair, proliferation, and apoptosis. TDRD11 is overexpressed in multiple cancers and functions as an oncogene. It contains multiple Staphylococcal nuclease (SN) domains and a C-terminal Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410504 [Multi-domain]  Cd Length: 84  Bit Score: 49.22  E-value: 1.72e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7023464  467 SESLDEALQRVNKKVEALPPLT--------DFrtempCLAEY-DDGLWYRAKIVAIKefNPLSILVQFVDYGSTAKLTLN 537
Cdd:cd20433   2 GPQLEKLMEKLRFEIASNPPLPgsytprkgDL-----CAAKFvEDGEWYRAKVEKVE--GDKKVHVLYIDYGNREVLPST 74
                        90
                ....*....|
gi 7023464  538 RLCQIPSHLM 547
Cdd:cd20433  75 RLAALPPAFS 84
Tudor_TDRD15_rpt3 cd20438
third Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; ...
287-365 1.86e-07

third Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410509  Cd Length: 141  Bit Score: 50.55  E-value: 1.86e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7023464  287 CAVRGSDTLWYRGKVMEVVGGAVRVQYLDHGFTEKIPQCHLYPIL-LYPDIPQFCIPCQLHNTTPVGNVWQPDAIEVLQQ 365
Cdd:cd20438  62 CARYSKDRHYYRAVITEVLDLKVSVYFLDFGNTDTVPFYDVKTLLpEFSELPALAMCCSLAHVFPVEEVWTKNANDFFKK 141
Tudor_TDRD9 cd20431
Tudor domain found in Tudor domain-containing protein 9 (TDRD9) and similar proteins; TDRD9 is ...
484-550 2.81e-07

Tudor domain found in Tudor domain-containing protein 9 (TDRD9) and similar proteins; TDRD9 is an ATP-dependent DEAD-like RNA helicase required during spermatogenesis. It is involved in the biosynthesis of PIWI-interacting RNAs (piRNAs). A recessive deleterious mutation mutation in TDRD9 causes non-obstructive azoospermia in infertile men. TDRD9 contains an N-terminal HrpA-like RNA helicase module and a Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410502  Cd Length: 101  Bit Score: 48.92  E-value: 2.81e-07
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7023464  484 LPPLTDFRTEMPCLAEYDDGL---WYRAKIVAIkefNPLSILVQFVDYGSTAKLTLNRLCQIPSHLMRYP 550
Cdd:cd20431  35 VPLTTKPVPNLLCLAPFTDADmkkYYRAKILYV---SGSSAEVFFVDYGNTSQVPSSLLREIPETLLTLP 101
Tudor_TDRD6_rpt5 cd20424
fifth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; ...
496-558 3.73e-07

fifth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410495  Cd Length: 126  Bit Score: 49.43  E-value: 3.73e-07
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 7023464  496 CLAEYDDGLWYRAKIVAIKEfnplSILVQFVDYGSTAKLTLNRLCQIPS---HLMRYPARAIKVLL 558
Cdd:cd20424  65 CLAKYSDQHWYRGIIITNKN----STEVFFVDYGNTEKVEKEDMLPIPSdayELLLLPMQAIKCSL 126
Tudor_TDRD1_rpt3 cd20410
third Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; ...
495-547 3.91e-07

third Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410481 [Multi-domain]  Cd Length: 59  Bit Score: 47.34  E-value: 3.91e-07
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*
gi 7023464  495 PCLAEY-DDGLWYRAkivAIKE-FNPLSILVQFVDYGSTAKLTLNRLCQIPSHLM 547
Cdd:cd20410   8 PCCAFFsGDGNWYRA---MVKEiLPGGAVKVHFVDYGNVEEVTLDKLRKITSTFL 59
Tudor_TDRD1_rpt2 cd20409
second Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; ...
468-547 4.27e-07

second Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410480  Cd Length: 82  Bit Score: 47.84  E-value: 4.27e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7023464  468 ESLDEALQRVNKKVEALPPLTDFRTEM--PCLAEY-DDGLWYRAKIVAIKefNPLSILVQFVDYGSTAKLTLNRLCQIPS 544
Cdd:cd20409   2 RQLAELQESLSAYCKVAPASSDFSPAVgeVCCAQFtEDNQWYRASVLAYS--SEDSVLVGYIDFGNSEEVALSRLRPIPP 79

                ...
gi 7023464  545 HLM 547
Cdd:cd20409  80 SLL 82
Tudor_TDRD11 cd20433
Tudor domain found in Tudor domain-containing protein 11 (TDRD11) and similar proteins; TDRD11, ...
261-330 5.91e-07

Tudor domain found in Tudor domain-containing protein 11 (TDRD11) and similar proteins; TDRD11, also called Staphylococcal nuclease domain-containing protein 1 (SND1), 100 kDa coactivator, EBNA2 coactivator p100, or p100 co-activator, is a multifunctional protein that is reportedly associated with different types of RNA molecules, including mRNA, miRNA, pre-miRNA, and dsRNA. It has been implicated in a number of biological processes in eukaryotic cells, including the cell cycle, DNA damage repair, proliferation, and apoptosis. TDRD11 is overexpressed in multiple cancers and functions as an oncogene. It contains multiple Staphylococcal nuclease (SN) domains and a C-terminal Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410504 [Multi-domain]  Cd Length: 84  Bit Score: 47.68  E-value: 5.91e-07
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 7023464  261 KMTNEIQSNLKCLGLLEPyfwKKGEACAVRGS-DTLWYRGKVMEVVGGA-VRVQYLDHGFTEKIPQCHLYPI 330
Cdd:cd20433  11 KLRFEIASNPPLPGSYTP---RKGDLCAAKFVeDGEWYRAKVEKVEGDKkVHVLYIDYGNREVLPSTRLAAL 79
Tudor_TDRD1_rpt3 cd20410
third Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; ...
282-330 2.54e-06

third Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410481 [Multi-domain]  Cd Length: 59  Bit Score: 45.02  E-value: 2.54e-06
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|.
gi 7023464  282 KKGEAC-AVRGSDTLWYRGKVMEVV-GGAVRVQYLDHGFTEKIPQCHLYPI 330
Cdd:cd20410   4 IVGEPCcAFFSGDGNWYRAMVKEILpGGAVKVHFVDYGNVEEVTLDKLRKI 54
TUDOR pfam00567
Tudor domain;
21-82 3.68e-06

Tudor domain;


Pssm-ID: 425754 [Multi-domain]  Cd Length: 117  Bit Score: 46.19  E-value: 3.68e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 7023464     21 CAVKIQDKNQWRRGQIIRMVTDTLVEVLLYDVGVELVVNVDCLRKLEENLKTMGRLSLECSL 82
Cdd:pfam00567  54 CVAAFSEDGKWYRAKITESLDDGLVEVLFIDYGNTETVPLSDLRPLPPELESLPPQAIKCQL 115
Tudor_TDRD4_rpt2 cd20415
second Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; ...
267-350 4.50e-06

second Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410486  Cd Length: 96  Bit Score: 45.50  E-value: 4.50e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7023464  267 QSNLKCLGLLEPYfwkKGEACAVRGSDTLWYRGKVMEVVGG-AVRVQYLDHGFTEKIPQCHLYPIllyPD----IPQFCI 341
Cdd:cd20415  14 EGDDGGLEILCPV---QGQACVALFEDGAWYRARIIGLPGHrEVEVKYVDFGNTATVTIKHVRKI---KDdflsLPEKAR 87

                ....*....
gi 7023464  342 PCQLHNTTP 350
Cdd:cd20415  88 ECRLAFIEP 96
Tudor_ZGPAT cd20384
Tudor domain found in zinc finger CCCH-type with G patch domain-containing protein (ZGPAT) and ...
496-534 5.06e-06

Tudor domain found in zinc finger CCCH-type with G patch domain-containing protein (ZGPAT) and similar proteins; ZGPAT, also called ZIP, G patch domain-containing protein 6 (GPATC6), GPATCH6, zinc finger CCCH domain-containing protein 9 (ZC3HDC9), ZC3H9, or zinc finger and G patch domain-containing protein, is a transcription repressor that specifically binds the 5'-GGAG[GA]A[GA]A-3' consensus sequence. It represses transcription by recruiting the chromatin multiprotein complex NuRD to target promoters. It contains one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410455  Cd Length: 55  Bit Score: 44.14  E-value: 5.06e-06
                        10        20        30
                ....*....|....*....|....*....|....*....
gi 7023464  496 CLAEYDDGLWYRAKIVAIKEFNplSILVQFVDYGSTAKL 534
Cdd:cd20384  11 CLAKYDDGLWYPATVTDIDEDG--KYTVKFDSYGEVAVV 47
TUDOR smart00333
Tudor domain; Domain of unknown function present in several RNA-binding proteins. 10 copies in ...
12-68 8.56e-06

Tudor domain; Domain of unknown function present in several RNA-binding proteins. 10 copies in the Drosophila Tudor protein. Initial proposal that the survival motor neuron gene product contain a Tudor domain are corroborated by more recent database search techniques such as PSI-BLAST (unpublished).


Pssm-ID: 197660  Cd Length: 57  Bit Score: 43.42  E-value: 8.56e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 7023464      12 PVKWENDMhCAVKIQDkNQWRRGQIIRMVTDTLVEVLLYDVGVELVVNVDCLRKLEE 68
Cdd:smart00333   1 PTFKVGDK-VAARWED-GEWYRARIVKVDGEQLYEVFFIDYGNEEVVPPSDLRQLPE 55
Tudor_TDRD1_rpt4 cd20411
fourth Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; ...
278-345 1.12e-05

fourth Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410482  Cd Length: 116  Bit Score: 44.74  E-value: 1.12e-05
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7023464  278 PYFWKKGEACAVR-GSDTLWYRGKVMEVVGGAVRVQYLDHGFTEKIPQCHLYPIL-LYPDIPQFCIPCQL 345
Cdd:cd20411  45 QFRPRIGDACCARfTGDKNWYRAVVLETSDSEVKVLYADYGNTETLPLSRILPITkSHLELPFQIIRCSL 114
Tudor_TDRD6_rpt6 cd20425
sixth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; ...
287-345 2.66e-05

sixth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the sixth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410496  Cd Length: 115  Bit Score: 43.60  E-value: 2.66e-05
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 7023464  287 CAVRGSDTLWYRGKVME-VVGGAVRVQYLDHGFTEKIPQCHLY---PILLypDIPQFCIPCQL 345
Cdd:cd20425  55 CAEYPEDGLWYRAVVKEkIPNNLVSVQFIDYGNTSVVQPSKIHrlpKELL--SIPALSIHCFL 115
Tudor_TDRD1_rpt1 cd20408
first Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; ...
467-564 2.66e-05

first Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410479  Cd Length: 130  Bit Score: 44.28  E-value: 2.66e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7023464  467 SESLDEALQRVNKKVEALPPLTDFrtempCLAEY-DDGLWYRAKIVAIKEFNPLSiLVQFVDYGSTAKLTLNRLCQIPSH 545
Cdd:cd20408  29 TSQLKKTYASVNNHKEYIPEVGEV-----CVAKYsEDQNWYRALVQTVDVQQKKA-GVFYIDYGNEETVPLNRIQPLKKD 102
                        90
                ....*....|....*....
gi 7023464  546 LMRYPARAIKVLLAGFKPP 564
Cdd:cd20408 103 IELFPPCAIKCCLANVKPP 121
Tudor_TDRD15_rpt6 cd20441
sixth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; ...
465-560 2.87e-05

sixth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the sixth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410512  Cd Length: 108  Bit Score: 43.58  E-value: 2.87e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7023464  465 SESES----LDEALQRVNKKVEALPpLTDFRTEMPCLAEYD-DGLWYRAKIVAIKEFNplSILVQFVDYGSTAKLTLNRL 539
Cdd:cd20441  10 SEDEKvilqLAEELNETSEKSRENA-AVKLKVGDLVAAEYDeDLALYRAVITAVLPGK--SFKVEFIDYGNTAVVDKSNI 86
                        90       100
                ....*....|....*....|.
gi 7023464  540 CQIPSHLMRYPARAIKVLLAG 560
Cdd:cd20441  87 YTLQEKFLSLPRLSIPCSLSG 107
Tudor_TDRD6_rpt3 cd20422
third Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; ...
16-101 3.28e-05

third Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410493  Cd Length: 135  Bit Score: 44.04  E-value: 3.28e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7023464   16 ENDMHCAVKIQDKNQWRrgQIIRMVTDTLVEVLLYDVGVELVVNVDCLRKLEENLKTMGRLSLECSLVDIRPAGgsDKWT 95
Cdd:cd20422  51 QPGQLCCAKWKEDRYYR--AIVTAVKGKMVEVFLVDRGNTEMVDWYDVKKLLPQFRELPALALKCCLADICPLG--ERWS 126

                ....*.
gi 7023464   96 ATACDC 101
Cdd:cd20422 127 PEAISA 132
Tudor_TDRD15_rpt2 cd20437
second Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; ...
255-345 4.13e-05

second Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410508  Cd Length: 120  Bit Score: 43.18  E-value: 4.13e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7023464  255 SEFELIKMTNEI----QSNLKCLGLLEPYFwkkGEACAVRGSDTLWYRGKVMEV-VGGAVRVQYLDHGFTEKIPQCHLYP 329
Cdd:cd20437  25 WEPELSKLTTQMtlhyESVSKELNPSCENF---GLLCAAKGKDGQWHRGFLQQLlPPSQVKVWFIDYGNSEAVSSHSVLK 101
                        90
                ....*....|....*....
gi 7023464  330 ilLYPD---IPQFCIPCQL 345
Cdd:cd20437 102 --LPPDffsLPLMSFPCSL 118
Tudor_TDRD6_rpt3 cd20422
third Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; ...
275-360 5.46e-05

third Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410493  Cd Length: 135  Bit Score: 43.27  E-value: 5.46e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7023464  275 LLEPyfwKKGEACAVRGSDTLWYRGKVMEVVGGAVRVQYLDHGFTEKIPQCHLYPILL-YPDIPQFCIPCQLHNTTPVGN 353
Cdd:cd20422  47 VLKP---QPGQLCCAKWKEDRYYRAIVTAVKGKMVEVFLVDRGNTEMVDWYDVKKLLPqFRELPALALKCCLADICPLGE 123

                ....*..
gi 7023464  354 VWQPDAI 360
Cdd:cd20422 124 RWSPEAI 130
Tudor_TDRD6_rpt3 cd20422
third Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; ...
424-584 1.11e-04

third Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410493  Cd Length: 135  Bit Score: 42.50  E-value: 1.11e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7023464  424 YAVQVKHVVSPNEVYIcldsiETSNQSNQHSDTDDSGVSGESESESLDEALQRvnkkvealPPLTDFrtempCLAEYDDG 503
Cdd:cd20422   2 YDAQVEFVKDPSEFWI-----RLGEHAVPFSKLMRSMTAFYSQASKLDGVVLK--------PQPGQL-----CCAKWKED 63
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7023464  504 LWYRAKIVAIKEfnpLSILVQFVDYGSTAKLTLNRLCQIPSHLMRYPARAIKVLLAgfkpplrDLGetriPYCPKWSMEA 583
Cdd:cd20422  64 RYYRAIVTAVKG---KMVEVFLVDRGNTEMVDWYDVKKLLPQFRELPALALKCCLA-------DIC----PLGERWSPEA 129

                .
gi 7023464  584 L 584
Cdd:cd20422 130 I 130
Tudor_TDRD15_rpt1 cd20436
first Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; ...
15-113 1.13e-04

first Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410507  Cd Length: 147  Bit Score: 42.79  E-value: 1.13e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7023464   15 WENDMHCAVKIQDKNQWRRGQIIRmVTDTLVEVLLYDVGVELVVNVDCLRKLEENLKTMGRLSLECSLVDIRPAGGsdKW 94
Cdd:cd20436  47 WGVGEFCLVEDTTSGEWYRGRVLE-KIDEKYEVFLIDRGEVLNVHATNMASASGELFQLPPKAVCGIFANILPIGE--KW 123
                        90       100
                ....*....|....*....|...
gi 7023464   95 TATACDCLS----LYLTGAVATI 113
Cdd:cd20436 124 SSTAVNYFSsligSQVKGYIQAI 146
Tudor_TDRD6_rpt2 cd20421
second Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; ...
282-346 1.43e-04

second Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410492  Cd Length: 130  Bit Score: 42.03  E-value: 1.43e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 7023464  282 KKGEACAVRGSDTLWYRGKVMEVVGG--AVRVQYLDHGFTEKIPQCHLYPILL-YPDIPQFCIPCQLH 346
Cdd:cd20421  62 KLGSPCAARGSDGRWYRAVLQQVFSAnrVVEVLHVDYGRKEVVSVSNLRYLAPeYFRMPVVTYPCALF 129
Tudor_TDRD15_rpt1 cd20436
first Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; ...
256-370 1.87e-04

first Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410507  Cd Length: 147  Bit Score: 42.02  E-value: 1.87e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7023464  256 EFELIKMTNEIQSNLKclgllEPYFWKKGEACAVRGSDT-LWYRGKVMEVVGGAVRVQYLDHGFTEKIPQCHLYPI---L 331
Cdd:cd20436  27 ELDYHILQNEIQNATK-----SKSSWGVGEFCLVEDTTSgEWYRGRVLEKIDEKYEVFLIDRGEVLNVHATNMASAsgeL 101
                        90       100       110
                ....*....|....*....|....*....|....*....
gi 7023464  332 LypDIPQFCIPCQLHNTTPVGNVWQPDAIEVLQQLLSKR 370
Cdd:cd20436 102 F--QLPPKAVCGIFANILPIGEKWSSTAVNYFSSLIGSQ 138
Tudor_TDRD12_rpt2 cd20435
second Tudor domain found in Tudor domain-containing protein 12 (TDRD12) and similar proteins; ...
282-328 2.44e-04

second Tudor domain found in Tudor domain-containing protein 12 (TDRD12) and similar proteins; TDRD12, also called ES cell-associated transcript 8 protein (ECAT8), is a putative ATP-dependent DEAD-like RNA helicase that is essential for germ cell development and maintenance. It acts as a unique piRNA biogenesis factor essential for secondary PIWI interacting RNA (piRNA) biogenesis. TDRD12 contains two Tudor domains, one at the N-terminus and the other at the C-terminal end. The model corresponds to the second/C-terminal one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410506  Cd Length: 134  Bit Score: 41.47  E-value: 2.44e-04
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....
gi 7023464  282 KKGEACAVRGSDTLWYRGKVMEVV-----GGA--VRVQYLDHGFTEKIPQCHLY 328
Cdd:cd20435  51 KVGDLCAVEDENNLYHRVKVLEITekddkTKPreVLVKFIDEGRVETVVVSQLL 104
Tudor_TDRD15_rpt2 cd20437
second Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; ...
21-82 2.45e-04

second Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410508  Cd Length: 120  Bit Score: 41.25  E-value: 2.45e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 7023464   21 CAVKIQDkNQWRRGQIIRMVTDTLVEVLLYDVGVELVVNVDCLRKLEENLKTMGRLSLECSL 82
Cdd:cd20437  58 CAAKGKD-GQWHRGFLQQLLPPSQVKVWFIDYGNSEAVSSHSVLKLPPDFFSLPLMSFPCSL 118
Tudor_TDRD7_rpt2 cd20428
second Tudor domain found in Tudor domain-containing protein 7 (TDRD7) and similar proteins; ...
496-563 2.71e-04

second Tudor domain found in Tudor domain-containing protein 7 (TDRD7) and similar proteins; TDRD7, also called PCTAIRE2-binding protein, or Tudor repeat associator with PCTAIRE-2 (Trap), is a component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. It is required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. It is also essential for dynamic ribonucleoprotein (RNP) remodeling of chromatoid bodies during spermatogenesis. TDRD7 contains three Tudor domains. The model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410499  Cd Length: 140  Bit Score: 41.66  E-value: 2.71e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 7023464  496 CLAEYDdGLWYRAKIVAIKEFNPLSilVQFVDYGSTAKLTLNRLCQIPSHLMR----YPARAIKVLLAGFKP 563
Cdd:cd20428  58 CLARYK-GKWARVEITNVHSSRALD--VHFLDTGTVASVKVSELREIPPPFLRelisIPPQALKCCLADLPL 126
Tudor_SMN_SPF30-like cd21182
Tudor domain found in survival motor neuron protein (SMN), motor neuron-related-splicing ...
494-542 2.86e-04

Tudor domain found in survival motor neuron protein (SMN), motor neuron-related-splicing factor 30 (SPF30), and similar proteins; This group contains SMN, SPF30, Tudor domain-containing protein 3 (TDRD3), DNA excision repair protein ERCC-6-like 2 (ERCC6L2), and similar proteins. SMN, also called component of gems 1, or Gemin-1, is part of a multimeric SMN complex that includes spliceosomal Sm core proteins and plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. SPF30, also called 30 kDa splicing factor SMNrp, SMN-related protein, or survival motor neuron domain-containing protein 1 (SMNDC1), is an essential pre-mRNA splicing factor required for assembly of the U4/U5/U6 tri-small nuclear ribonucleoprotein into the spliceosome. TDRD3 is a scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins. ERCC6L2, also called DNA repair and recombination protein RAD26-like (RAD26L), may be involved in early DNA damage response. It regulates RNA Pol II-mediated transcription via its interaction with DNA-dependent protein kinase (DNA-PK) to resolve R loops and minimize transcription-associated genome instability. Members of this group contain a single Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410549  Cd Length: 50  Bit Score: 38.77  E-value: 2.86e-04
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|
gi 7023464  494 MPCLAEY-DDGLWYRAKIVAIKEfNPLSILVQFVDYGSTAKLTLNRLCQI 542
Cdd:cd21182   2 DKCLAPYsDDGKYYEATIEEITE-ESDTATVVFDGYGNSEEVPLSDLKPL 50
Tudor_TDRD7_rpt1 cd20427
first Tudor domain found in Tudor domain-containing protein 7 (TDRD7) and similar proteins; ...
468-563 4.11e-04

first Tudor domain found in Tudor domain-containing protein 7 (TDRD7) and similar proteins; TDRD7, also called PCTAIRE2-binding protein, or Tudor repeat associator with PCTAIRE-2 (Trap), is a component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. It is required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. It is also essential for dynamic ribonucleoprotein (RNP) remodeling of chromatoid bodies during spermatogenesis. TDRD7 contains three Tudor domains. The model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410498  Cd Length: 98  Bit Score: 40.10  E-value: 4.11e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7023464  468 ESLDEALQRVNKKVEALPPLTDFRTEMPCLAEYDDGLWYRAKIVAIKEfnpLSILVQFVDYGSTAKLTLNRLCQIPSHLM 547
Cdd:cd20427   1 EQMEDEMKEFYSKSSTAMCLRSPSVGQLVAVKAEEDAWLRAQVIEVEE---DKVKVYYVDHGFSEVVERSKLFKLNKQFY 77
                        90
                ....*....|....*.
gi 7023464  548 RYPARAIKVLLAGFKP 563
Cdd:cd20427  78 SLPFQATKCKLAGLEP 93
Tudor_TDRD15_rpt7 cd20442
seventh Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; ...
19-80 6.93e-04

seventh Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the seventh one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410513  Cd Length: 160  Bit Score: 40.79  E-value: 6.93e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 7023464   19 MHCAVKIQDKNQWRRGQIIRMVTDTL-VEVLLYDVGVELVVNVDCLRKLEENLKTMGRLSLEC 80
Cdd:cd20442  54 LECLAKSKKNLKWYRAVVEHLYPETEkMLVFFVDHGITEVVSMGNIKQLSNDLLQIPRQAVLC 116
Tudor_TDRD7_rpt1 cd20427
first Tudor domain found in Tudor domain-containing protein 7 (TDRD7) and similar proteins; ...
261-340 1.02e-03

first Tudor domain found in Tudor domain-containing protein 7 (TDRD7) and similar proteins; TDRD7, also called PCTAIRE2-binding protein, or Tudor repeat associator with PCTAIRE-2 (Trap), is a component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. It is required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. It is also essential for dynamic ribonucleoprotein (RNP) remodeling of chromatoid bodies during spermatogenesis. TDRD7 contains three Tudor domains. The model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410498  Cd Length: 98  Bit Score: 38.95  E-value: 1.02e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7023464  261 KMTNEIQSNLKCLGLLEPyfwKKGEACAVRGSDTLWYRGKVMEVVGGAVRVQYLDHGFTEKIPQCHLYPILlypdiPQFC 340
Cdd:cd20427   6 EMKEFYSKSSTAMCLRSP---SVGQLVAVKAEEDAWLRAQVIEVEEDKVKVYYVDHGFSEVVERSKLFKLN-----KQFY 77
Tudor_TDRD15_rpt4 cd20439
fourth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; ...
496-561 1.08e-03

fourth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410510  Cd Length: 125  Bit Score: 39.40  E-value: 1.08e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 7023464  496 CLAEY-DDGLWYRAKIVaiKEFNPLSILVQFVDYGSTAKLTLNRLCQIPSHLMRYPARAIKVLLAGF 561
Cdd:cd20439  61 CVAKYsKDGKWYRAAVL--KQVSAKEVDVIFVDYGNQERVLISDLRAIKPQFLLLEGQAFRCSLNNF 125
Tudor_vreteno-like_rpt1 cd20444
first Tudor domain found in Drosophila melanogaster protein vreteno and similar proteins; ...
494-546 1.17e-03

first Tudor domain found in Drosophila melanogaster protein vreteno and similar proteins; Vreteno is a gonad-specific protein essential for germline development to repress transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process in both germline and somatic gonadal tissues by mediating the repression of transposable elements during meiosis. Vreteno contains two Tudor domains. The model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410515  Cd Length: 55  Bit Score: 37.28  E-value: 1.17e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|...
gi 7023464  494 MPCLAEYDdGLWYRAKIVAIKEFNPlSILVQFVDYGSTAKLTLNRLCQIPSHL 546
Cdd:cd20444   5 QMVIAKFD-GNHYRAIVLRVLNPDL-KILVRFVDFGNVEVMKLENLYECPEYL 55
Tudor_TDRD6_rpt6 cd20425
sixth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; ...
18-82 1.71e-03

sixth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the sixth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410496  Cd Length: 115  Bit Score: 38.59  E-value: 1.71e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 7023464   18 DMHCAVKIQDkNQWRRGQIIRMVTDTLVEVLLYDVGVELVVNVDCLRKLEENLKTMGRLSLECSL 82
Cdd:cd20425  52 DLICAEYPED-GLWYRAVVKEKIPNNLVSVQFIDYGNTSVVQPSKIHRLPKELLSIPALSIHCFL 115
Tudor_TDRD1_rpt4 cd20411
fourth Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; ...
496-560 2.63e-03

fourth Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410482  Cd Length: 116  Bit Score: 38.20  E-value: 2.63e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 7023464  496 CLAEYD-DGLWYRAKIVAIKEfnpLSILVQFVDYGSTAKLTLNRLCQIPSHLMRYPARAIKVLLAG 560
Cdd:cd20411  54 CCARFTgDKNWYRAVVLETSD---SEVKVLYADYGNTETLPLSRILPITKSHLELPFQIIRCSLAG 116
Tudor_TDRD2 cd20412
Tudor domain found in Tudor domain-containing protein 2 (TDRD2) and similar proteins; TDRD2, ...
501-554 3.12e-03

Tudor domain found in Tudor domain-containing protein 2 (TDRD2) and similar proteins; TDRD2, also called Tudor and KH domain-containing protein (TDRKH), participates in the primary piwi-interacting RNA (piRNA) biogenesis pathway and is required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for germline integrity. The family also includes the TDRD2 homolog found in Drosophila melanogaster (dTDRKH), which is also called partner of PIWIs protein, or PAPI, and is involved in Zucchini-mediated piRNA 3'-end maturation. TDRD2 contains two KH domains and one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410483  Cd Length: 95  Bit Score: 37.27  E-value: 3.12e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....
gi 7023464  501 DDGLWYRAKIVAIKEfnPLSILVQFVDYGSTAKLTLNRLCQIPSHLMRYPARAI 554
Cdd:cd20412  41 HDGSWYRARVLGFLE--NGNLDLYFVDYGDSGYVPLEDLRALRSDFLSLPFQAI 92
Tudor_TDRD7_rpt3 cd20429
third Tudor domain found in Tudor domain-containing protein 7 (TDRD7) and similar proteins; ...
1-68 7.99e-03

third Tudor domain found in Tudor domain-containing protein 7 (TDRD7) and similar proteins; TDRD7, also called PCTAIRE2-binding protein, or Tudor repeat associator with PCTAIRE-2 (Trap), is a component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. It is required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. It is also essential for dynamic ribonucleoprotein (RNP) remodeling of chromatoid bodies during spermatogenesis. TDRD7 contains three Tudor domains. The model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410500  Cd Length: 91  Bit Score: 35.93  E-value: 7.99e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 7023464    1 MIAAYENSKWEPVKWENDMHCAVKIQdkNQWRRGQIIRMVTDTLVEVLLYDVGVELVVNVDCLRKLEE 68
Cdd:cd20429  16 MILYYNKTEERPVAIEKNKVYAAKIE--NNWYRVLVKGILTNGLVSVYELDYGKHELVSIRKVQPLIE 81
Tudor_TDRD3 cd20413
Tudor domain found in Tudor domain-containing protein 3 (TDRD3) and similar proteins; TDRD3 is ...
495-529 9.28e-03

Tudor domain found in Tudor domain-containing protein 3 (TDRD3) and similar proteins; TDRD3 is a scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins. In the nucleus, it acts as a coactivator; it recognizes and binds asymmetric dimethylation on the core histone tails associated with transcriptional activation (H3R17me2a and H4R3me2a) and recruits proteins at these arginine-methylated loci. In the cytoplasm, it may play a role in the assembly and/or disassembly of mRNA stress granules and in the regulation of translation of target mRNAs by binding Arg/Gly-rich motifs (GAR) in dimethylarginine-containing proteins. TDRD3 contains one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410484  Cd Length: 53  Bit Score: 34.62  E-value: 9.28e-03
                        10        20        30
                ....*....|....*....|....*....|....*.
gi 7023464  495 PCLAEY-DDGLWYRAKIVAIKEFNPLSIlVQFVDYG 529
Cdd:cd20413   6 ECLAKYwEDNKFYRAEVTAVHPSGKTAV-VKFMEYG 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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