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Conserved domains on  [gi|7259294|dbj|BAA92763|]
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unnamed protein product [Mus musculus]

Protein Classification

trafficking protein particle complex subunit 2-like protein( domain architecture ID 13000929)

trafficking protein particle complex subunit 2-like protein (TRAPPC2L) plays a role in vesicular transport from endoplasmic reticulum to Golgi

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TRAPPC2L cd14854
Trafficking protein particle complex subunit 2-like; Trafficking protein particle complex ...
 3-135 2.57e-72

Trafficking protein particle complex subunit 2-like; Trafficking protein particle complex subunit 2-like (TRAPPC2L) is related to TRAPPC2. Its function is not known, but there are indications that it is part of the TRAPP II complex, which is required for distinct tethering events at Golgi membranes. TRAPPC2 has been identified as a general component of transport protein particle (TRAPP), required for tethering endoplasmic reticulum (ER)-derived vesicles to Golgi membranes and for Golgi traffic.


:

Pssm-ID: 341444  Cd Length: 135  Bit Score: 212.45  E-value: 2.57e-72
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7259294    3 VCIAVIAKENYPLYIRSTP--TESELKFHYMVHTSLDVVDEKISAMGKAlVDQRELYLGLLYPTEDYKVYGYVTNSKVKF 80
Cdd:cd14854   1 VCVAVIGKQNNPLYLRTFPsgEDNDLKLHYIAHSSLDVVEEKLSASKKG-GDTSDMYLGLLYPTEDYKVYGYVTNTKVKF 79

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 7259294   81 VMVVDSSNTALRDNEIRSMFRKLHNSYTDVMCNPFYNPGDRIQSRAFDTMVTSMM 135
Cdd:cd14854  80 ILVLEDTNTPLRDNDVRTLFRRLHNAYVDAVSNPFYPPGTPITSKKFDRRVDSLV 134
 
Name Accession Description Interval E-value
TRAPPC2L cd14854
Trafficking protein particle complex subunit 2-like; Trafficking protein particle complex ...
 3-135 2.57e-72

Trafficking protein particle complex subunit 2-like; Trafficking protein particle complex subunit 2-like (TRAPPC2L) is related to TRAPPC2. Its function is not known, but there are indications that it is part of the TRAPP II complex, which is required for distinct tethering events at Golgi membranes. TRAPPC2 has been identified as a general component of transport protein particle (TRAPP), required for tethering endoplasmic reticulum (ER)-derived vesicles to Golgi membranes and for Golgi traffic.


Pssm-ID: 341444  Cd Length: 135  Bit Score: 212.45  E-value: 2.57e-72
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7259294    3 VCIAVIAKENYPLYIRSTP--TESELKFHYMVHTSLDVVDEKISAMGKAlVDQRELYLGLLYPTEDYKVYGYVTNSKVKF 80
Cdd:cd14854   1 VCVAVIGKQNNPLYLRTFPsgEDNDLKLHYIAHSSLDVVEEKLSASKKG-GDTSDMYLGLLYPTEDYKVYGYVTNTKVKF 79

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 7259294   81 VMVVDSSNTALRDNEIRSMFRKLHNSYTDVMCNPFYNPGDRIQSRAFDTMVTSMM 135
Cdd:cd14854  80 ILVLEDTNTPLRDNDVRTLFRRLHNAYVDAVSNPFYPPGTPITSKKFDRRVDSLV 134
Sedlin_N pfam04628
Sedlin, N-terminal conserved region; Mutations in this protein are associated with the ...
 7-137 1.53e-44

Sedlin, N-terminal conserved region; Mutations in this protein are associated with the X-linked spondyloepiphyseal dysplasia tarda syndrome (OMIM:313400). This family represents an N-terminal conserved region.


Pssm-ID: 335859  Cd Length: 129  Bit Score: 142.02  E-value: 1.53e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7259294      7 VIAKENYPLYIR--STPTESELK-----FHYMVHTSLDVVDEKISAmgkalvdQRELYLGLLYPTEDYKVYGYVTNSKVK 79
Cdd:pfam04628   1 IIGKKDNPLYEQefSTSGQTEDKehkhlNQFIAHASLDIVDELQWK-------TNNMYLGTIDKFYKLSVSAYVTNSHIK 73

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 7259294     80 FVMVVDSSNtaLRDNEIRSMFRKLHNSYTDVMCNPFYNPGDRIQSRAFDTMVTSMMIQ 137
Cdd:pfam04628  74 FILVHESST--KSDENIKQFFQEVHELYVKTLMNPFYKPNDPIRSPAFDKKVRKLAKK 129
TRS20 COG5603
Subunit of TRAPP, an ER-Golgi tethering complex [Cell motility and secretion];
1-134 4.87e-12

Subunit of TRAPP, an ER-Golgi tethering complex [Cell motility and secretion];


Pssm-ID: 227890  Cd Length: 136  Bit Score: 59.15  E-value: 4.87e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7259294    1 MAVCIAVIAKENYPLYIRSTPTESELKF--------HYMVHTSLDVVDEKISAMGKAlvdqrelYLGLLYPTEDYKVYGY 72
Cdd:COG5603   1 MGEYLAIIGEKDNPVYEREYDPINKTSDgeycrllnQFIIHASLDIVVWLQWSVNTS-------YFDCLDSFGDLRISAY 73

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 7259294   73 VTNSKVKFVMVVDSSNtalrDNEIRSMFRKLHNSYTDVMCNPFYNPGDRIQSRAFDTMVTSM 134
Cdd:COG5603  74 IMPSGMKFLFIHQNQS----RKNARSFLQEVHELYAKTLMSPFYEPDEPIRSQAFDDGVREA 131
 
Name Accession Description Interval E-value
TRAPPC2L cd14854
Trafficking protein particle complex subunit 2-like; Trafficking protein particle complex ...
 3-135 2.57e-72

Trafficking protein particle complex subunit 2-like; Trafficking protein particle complex subunit 2-like (TRAPPC2L) is related to TRAPPC2. Its function is not known, but there are indications that it is part of the TRAPP II complex, which is required for distinct tethering events at Golgi membranes. TRAPPC2 has been identified as a general component of transport protein particle (TRAPP), required for tethering endoplasmic reticulum (ER)-derived vesicles to Golgi membranes and for Golgi traffic.


Pssm-ID: 341444  Cd Length: 135  Bit Score: 212.45  E-value: 2.57e-72
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7259294    3 VCIAVIAKENYPLYIRSTP--TESELKFHYMVHTSLDVVDEKISAMGKAlVDQRELYLGLLYPTEDYKVYGYVTNSKVKF 80
Cdd:cd14854   1 VCVAVIGKQNNPLYLRTFPsgEDNDLKLHYIAHSSLDVVEEKLSASKKG-GDTSDMYLGLLYPTEDYKVYGYVTNTKVKF 79

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 7259294   81 VMVVDSSNTALRDNEIRSMFRKLHNSYTDVMCNPFYNPGDRIQSRAFDTMVTSMM 135
Cdd:cd14854  80 ILVLEDTNTPLRDNDVRTLFRRLHNAYVDAVSNPFYPPGTPITSKKFDRRVDSLV 134
Sedlin_N pfam04628
Sedlin, N-terminal conserved region; Mutations in this protein are associated with the ...
 7-137 1.53e-44

Sedlin, N-terminal conserved region; Mutations in this protein are associated with the X-linked spondyloepiphyseal dysplasia tarda syndrome (OMIM:313400). This family represents an N-terminal conserved region.


Pssm-ID: 335859  Cd Length: 129  Bit Score: 142.02  E-value: 1.53e-44
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7259294      7 VIAKENYPLYIR--STPTESELK-----FHYMVHTSLDVVDEKISAmgkalvdQRELYLGLLYPTEDYKVYGYVTNSKVK 79
Cdd:pfam04628   1 IIGKKDNPLYEQefSTSGQTEDKehkhlNQFIAHASLDIVDELQWK-------TNNMYLGTIDKFYKLSVSAYVTNSHIK 73

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 7259294     80 FVMVVDSSNtaLRDNEIRSMFRKLHNSYTDVMCNPFYNPGDRIQSRAFDTMVTSMMIQ 137
Cdd:pfam04628  74 FILVHESST--KSDENIKQFFQEVHELYVKTLMNPFYKPNDPIRSPAFDKKVRKLAKK 129
TRAPPC_longin-like cd14853
Longin-like domains of Trafficking protein particle complex; Longin-like domains of a ...
 3-134 1.96e-20

Longin-like domains of Trafficking protein particle complex; Longin-like domains of a subfamily of core components of the trafficking protein particle complex (TRAPP), including TRAPPC2, TRAPPC4, TRAPPC1 and a TRAPPC2L, whose function is not known. TRAPP complexes are required for tethering endoplasmic reticulum (ER)-derived vesicles to Golgi membranes and for Golgi traffic.


Pssm-ID: 341443  Cd Length: 132  Bit Score: 80.61  E-value: 1.96e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7259294    3 VCIAVIAKENYPLYIRS-TPTESELKFH-----YMVHTSLDVVDEKisamgKALVDQRELYLGLLYPTEDYKVYGYVTNS 76
Cdd:cd14853   1 FYFVVVGHHGNPLYEREfTPPGQAEDDNeeeykLLAGMLHSVRSIN-----SKLSPNVEKYLKLSDKTNEYKVHAYVTAT 75

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 7259294   77 KVKFVMVVDSSNTALRDNeIRSMFRKLHNSYTDVMCNPFYNPGDRIQSRAFDTMVTSM 134
Cdd:cd14853  76 GLKFVMLTDVLMDRIEDV-LKNFFSDLYVLYVKKNPNPFYEPNSPIRSRLFDSKVQSL 132
TRAPPC2_sedlin cd14825
Trafficking protein particle complex subunit 2; Trafficking protein particle complex subunit 2 ...
 6-131 4.68e-16

Trafficking protein particle complex subunit 2; Trafficking protein particle complex subunit 2 (TRAPPC2), also known as Sedlin (SEDL) or TRS20, has been identified as a component of the transport protein particle (TRAPP), required for tethering endoplasmic reticulum (ER)-derived vesicles to Golgi membranes and for Golgi traffic. In humans, deletions or point mutations in the SEDL gene cause the genetic disease spondyloepiphyseal dysplasia tarda (SEDT), an X-linked skeletal disorder.


Pssm-ID: 341429  Cd Length: 135  Bit Score: 69.48  E-value: 4.68e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7259294    6 AVIAKENYPLYIRSTPTESELKF--------HYMVHTSLDVVDEKISAMGKalvdqreLYLGLLYPTEDYKVYGYVTNSK 77
Cdd:cd14825   5 VIVGPNDNPLYEAEFGSSKKSEFrddhrhlnQFIAHAALDLVDELQWTTNN-------MYLKSVDRFNEWSVSAFVTAGN 77

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 7259294   78 VKFVMVVDSSNtalrDNEIRSMFRKLHNSYTDVMCNPFYNPGDRIQSRAFDTMV 131
Cdd:cd14825  78 IRFLLLHDNKN----DDGIKNFFQEVYELYVKILMNPFYEPNTPIRSPAFDRRV 127
TRS20 COG5603
Subunit of TRAPP, an ER-Golgi tethering complex [Cell motility and secretion];
1-134 4.87e-12

Subunit of TRAPP, an ER-Golgi tethering complex [Cell motility and secretion];


Pssm-ID: 227890  Cd Length: 136  Bit Score: 59.15  E-value: 4.87e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7259294    1 MAVCIAVIAKENYPLYIRSTPTESELKF--------HYMVHTSLDVVDEKISAMGKAlvdqrelYLGLLYPTEDYKVYGY 72
Cdd:COG5603   1 MGEYLAIIGEKDNPVYEREYDPINKTSDgeycrllnQFIIHASLDIVVWLQWSVNTS-------YFDCLDSFGDLRISAY 73

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 7259294   73 VTNSKVKFVMVVDSSNtalrDNEIRSMFRKLHNSYTDVMCNPFYNPGDRIQSRAFDTMVTSM 134
Cdd:COG5603  74 IMPSGMKFLFIHQNQS----RKNARSFLQEVHELYAKTLMSPFYEPDEPIRSQAFDDGVREA 131
Sybindin pfam04099
Sybindin-like family; Sybindin is a physiological syndecan-2 ligand on dendritic spines, the ...
 60-129 3.98e-06

Sybindin-like family; Sybindin is a physiological syndecan-2 ligand on dendritic spines, the small protrusions on the surface of dendrites that receive the vast majority of excitatory synapses.


Pssm-ID: 282019  Cd Length: 134  Bit Score: 43.46  E-value: 3.98e-06
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 7259294     60 LLYPTEDYKVYGYVTNSKVKFVMVVDSSNTALRDneirSMFRKLHNSYTD-VMCNPFYNPGDRIQSRAFDT 129
Cdd:pfam04099  59 ESLETDTFKLHCLETLTGIKFVLVTDPGTGINRD----SLLRKYYELYSDyVLKNPFYSLGMPIRCELFDE 125
TRAPPC4_synbindin cd14856
Trafficking protein particle complex subunit 4; Trafficking protein particle complex subunit 4 ...
 64-134 5.75e-06

Trafficking protein particle complex subunit 4; Trafficking protein particle complex subunit 4 (TRAPPC4), also known as synbindin or TRS23, has been identified as a component of the transport protein particle (TRAPP), required for tethering endoplasmic reticulum (ER)-derived vesicles to Golgi membranes and for Golgi traffic.


Pssm-ID: 341446  Cd Length: 127  Bit Score: 42.89  E-value: 5.75e-06
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 7259294   64 TEDYKVYGYVTNSKVKFVMVVDSSNTALRdneirSMFRKLHNSYTD-VMCNPFYNPGDRIQSRAFDTMVTSM 134
Cdd:cd14856  61 TDTFRLHCFQTLTGIKFVLVADPKQPGLD-----ALLRRVYELYADyVLKNPFYELEMPIRCELFDENLQKL 127
TRAPPC1_MUM2 cd14855
Trafficking protein particle complex subunit 1; Trafficking protein particle complex subunit 1 ...
 62-131 1.68e-05

Trafficking protein particle complex subunit 1; Trafficking protein particle complex subunit 1 (TRAPPC1), also known as MUM2 and BET5, has been identified as a component of the transport protein particle (TRAPP), required for tethering endoplasmic reticulum (ER)-derived vesicles to Golgi membranes and for Golgi traffic.


Pssm-ID: 341445  Cd Length: 132  Bit Score: 41.76  E-value: 1.68e-05
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 7259294   62 YPTEDYKVYGYVTNSKVKFVMVVDSSNTALRDnEIRSMFRKLHNSYtdVMCNPFYNPGDRIQSRAFDTMV 131
Cdd:cd14855  63 YTTNKYKLHYYETPTGLKFVLLTDPNVGDLRD-VLQQIYSNIYVEY--VVKNPLYPPGEPITSELFRSKL 129
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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