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Conserved domains on  [gi|10435007|dbj|BAB14454|]
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unnamed protein product [Homo sapiens]

Protein Classification

TBC domain-containing protein( domain architecture ID 10640016)

TBC (Tre-2/Bub2/Cdc1) domain-containing protein may function as a GTPase activator protein of Rab-like small GTPases

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
TBC smart00164
Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs; Widespread domain present in Gyp6 and ...
82-287 1.45e-61

Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs; Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases.


:

Pssm-ID: 214540 [Multi-domain]  Cd Length: 216  Bit Score: 201.38  E-value: 1.45e-61
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10435007     82 CRKGIPSSLRAKAWQYLSNSKEL-LEQNPGKFEELER--APGDPKWLDVIEKDLHRQFPFHEMFAARGGHGQQDLYRILK 158
Cdd:smart00164   1 VRKGVPPSLRGVVWKLLLNAQPMdTSADKDLYSRLLKetAPDDKSIVHQIEKDLRRTFPEHSFFQDKEGPGQESLRRVLK 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10435007    159 AYTIYRPDEGYCQAQAPVAAVLLMHMPAEQ-AFWCLVQICDKYLPGYYSAGLEAIQLDGEIFFALLRRASPLAHRHLRRQ 237
Cdd:smart00164  81 AYALYNPEVGYCQGMNFLAAPLLLVMEDEEdAFWCLVKLMERYGPNFYLPDMSGLQLDLLQLDRLVKEYDPDLYKHLKDL 160
                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|
gi 10435007    238 RIDPVLYMTEWFMCIFARTLPWASVLRVWDMFFCEGVKIIFRVALVLLRH 287
Cdd:smart00164 161 GITPSLYALRWFLTLFARELPLEIVLRIWDVLFAEGSDFLFRVALALLKL 210
 
Name Accession Description Interval E-value
TBC smart00164
Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs; Widespread domain present in Gyp6 and ...
82-287 1.45e-61

Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs; Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases.


Pssm-ID: 214540 [Multi-domain]  Cd Length: 216  Bit Score: 201.38  E-value: 1.45e-61
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10435007     82 CRKGIPSSLRAKAWQYLSNSKEL-LEQNPGKFEELER--APGDPKWLDVIEKDLHRQFPFHEMFAARGGHGQQDLYRILK 158
Cdd:smart00164   1 VRKGVPPSLRGVVWKLLLNAQPMdTSADKDLYSRLLKetAPDDKSIVHQIEKDLRRTFPEHSFFQDKEGPGQESLRRVLK 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10435007    159 AYTIYRPDEGYCQAQAPVAAVLLMHMPAEQ-AFWCLVQICDKYLPGYYSAGLEAIQLDGEIFFALLRRASPLAHRHLRRQ 237
Cdd:smart00164  81 AYALYNPEVGYCQGMNFLAAPLLLVMEDEEdAFWCLVKLMERYGPNFYLPDMSGLQLDLLQLDRLVKEYDPDLYKHLKDL 160
                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|
gi 10435007    238 RIDPVLYMTEWFMCIFARTLPWASVLRVWDMFFCEGVKIIFRVALVLLRH 287
Cdd:smart00164 161 GITPSLYALRWFLTLFARELPLEIVLRIWDVLFAEGSDFLFRVALALLKL 210
RabGAP-TBC pfam00566
Rab-GTPase-TBC domain; Identification of a TBC domain in GYP6_YEAST and GYP7_YEAST, which are ...
124-287 4.22e-55

Rab-GTPase-TBC domain; Identification of a TBC domain in GYP6_YEAST and GYP7_YEAST, which are GTPase activator proteins of yeast Ypt6 and Ypt7, implies that these domains are GTPase activator proteins of Rab-like small GTPases.


Pssm-ID: 459855  Cd Length: 178  Bit Score: 183.22  E-value: 4.22e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10435007   124 WLDVIEKDLHRQFPFHEMFaaRGGHGQQDLYRILKAYTIYRPDEGYCQAQAPVAAVLLM-HMPAEQAFWCLVQICDKY-L 201
Cdd:pfam00566   8 WPEQIEKDVPRTFPHSFFF--DNGPGQNSLRRILKAYSIYNPDVGYCQGMNFIAAPLLLvYLDEEDAFWCFVSLLENYlL 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10435007   202 PGYYSAGLEAIQLDGEIFFALLRRASPLAHRHLRRQRIDPVLYMTEWFMCIFARTLPWASVLRVWDMFFCEGVKI-IFRV 280
Cdd:pfam00566  86 RDFYTPDFPGLKRDLYVFEELLKKKLPKLYKHLKELGLDPDLFASQWFLTLFAREFPLSTVLRIWDYFFLEGEKFvLFRV 165

                  ....*..
gi 10435007   281 ALVLLRH 287
Cdd:pfam00566 166 ALAILKR 172
COG5210 COG5210
GTPase-activating protein [General function prediction only];
17-313 1.79e-53

GTPase-activating protein [General function prediction only];


Pssm-ID: 227535 [Multi-domain]  Cd Length: 496  Bit Score: 188.47  E-value: 1.79e-53
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10435007  17 SDSEINGLALRKTDKYGFlggsqYSGSLESSIPVDVARQRELKWLDMF-SNWDKWLSRRFQKVKLRCRKGIPSSLRAKAW 95
Cdd:COG5210 148 KGSSSLNSNPELNKEINE-----LSLKEEPQKLRYYELAADKLWISYLdPNPLSFLPVQLSKLRELIRKGIPNELRGDVW 222
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10435007  96 QYLSNSKELLEQNPGKFEELERAP---GDPKWLDV--IEKDLHRQFPFHEMFAARGGHGQQDLYRILKAYTIYRPDEGYC 170
Cdd:COG5210 223 EFLLGIGFDLDKNPGLYERLLNLHreaKIPTQEIIsqIEKDLSRTFPDNSLFQTEISIRAENLRRVLKAYSLYNPEVGYV 302
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10435007 171 QAQAPVAAVLLMHMPAE-QAFWCLVQICDK-YLPGYYSAGLEAIQLDGEIFFALLRRASPLAHRHLRRQRIDPVLYMTEW 248
Cdd:COG5210 303 QGMNFLAAPLLLVLESEeQAFWCLVKLLKNyGLPGYFLKNLSGLHRDLKVLDDLVEELDPELYEHLLREGVVLLMFAFRW 382
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 10435007 249 FMCIFARTLPWASVLRVWDMFFCEGVKIIFRVALVLLrhtLGSVEKLRSCQGMYETMEQLRNLPQ 313
Cdd:COG5210 383 FLTLFVREFPLEYALRIWDCLFLEGSSMLFQLALAIL---KLLRDKLLKLDSDELLDLLLKQLFL 444
 
Name Accession Description Interval E-value
TBC smart00164
Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs; Widespread domain present in Gyp6 and ...
82-287 1.45e-61

Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs; Widespread domain present in Gyp6 and Gyp7, thereby giving rise to the notion that it performs a GTP-activator activity on Rab-like GTPases.


Pssm-ID: 214540 [Multi-domain]  Cd Length: 216  Bit Score: 201.38  E-value: 1.45e-61
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10435007     82 CRKGIPSSLRAKAWQYLSNSKEL-LEQNPGKFEELER--APGDPKWLDVIEKDLHRQFPFHEMFAARGGHGQQDLYRILK 158
Cdd:smart00164   1 VRKGVPPSLRGVVWKLLLNAQPMdTSADKDLYSRLLKetAPDDKSIVHQIEKDLRRTFPEHSFFQDKEGPGQESLRRVLK 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10435007    159 AYTIYRPDEGYCQAQAPVAAVLLMHMPAEQ-AFWCLVQICDKYLPGYYSAGLEAIQLDGEIFFALLRRASPLAHRHLRRQ 237
Cdd:smart00164  81 AYALYNPEVGYCQGMNFLAAPLLLVMEDEEdAFWCLVKLMERYGPNFYLPDMSGLQLDLLQLDRLVKEYDPDLYKHLKDL 160
                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|
gi 10435007    238 RIDPVLYMTEWFMCIFARTLPWASVLRVWDMFFCEGVKIIFRVALVLLRH 287
Cdd:smart00164 161 GITPSLYALRWFLTLFARELPLEIVLRIWDVLFAEGSDFLFRVALALLKL 210
RabGAP-TBC pfam00566
Rab-GTPase-TBC domain; Identification of a TBC domain in GYP6_YEAST and GYP7_YEAST, which are ...
124-287 4.22e-55

Rab-GTPase-TBC domain; Identification of a TBC domain in GYP6_YEAST and GYP7_YEAST, which are GTPase activator proteins of yeast Ypt6 and Ypt7, implies that these domains are GTPase activator proteins of Rab-like small GTPases.


Pssm-ID: 459855  Cd Length: 178  Bit Score: 183.22  E-value: 4.22e-55
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10435007   124 WLDVIEKDLHRQFPFHEMFaaRGGHGQQDLYRILKAYTIYRPDEGYCQAQAPVAAVLLM-HMPAEQAFWCLVQICDKY-L 201
Cdd:pfam00566   8 WPEQIEKDVPRTFPHSFFF--DNGPGQNSLRRILKAYSIYNPDVGYCQGMNFIAAPLLLvYLDEEDAFWCFVSLLENYlL 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10435007   202 PGYYSAGLEAIQLDGEIFFALLRRASPLAHRHLRRQRIDPVLYMTEWFMCIFARTLPWASVLRVWDMFFCEGVKI-IFRV 280
Cdd:pfam00566  86 RDFYTPDFPGLKRDLYVFEELLKKKLPKLYKHLKELGLDPDLFASQWFLTLFAREFPLSTVLRIWDYFFLEGEKFvLFRV 165

                  ....*..
gi 10435007   281 ALVLLRH 287
Cdd:pfam00566 166 ALAILKR 172
COG5210 COG5210
GTPase-activating protein [General function prediction only];
17-313 1.79e-53

GTPase-activating protein [General function prediction only];


Pssm-ID: 227535 [Multi-domain]  Cd Length: 496  Bit Score: 188.47  E-value: 1.79e-53
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10435007  17 SDSEINGLALRKTDKYGFlggsqYSGSLESSIPVDVARQRELKWLDMF-SNWDKWLSRRFQKVKLRCRKGIPSSLRAKAW 95
Cdd:COG5210 148 KGSSSLNSNPELNKEINE-----LSLKEEPQKLRYYELAADKLWISYLdPNPLSFLPVQLSKLRELIRKGIPNELRGDVW 222
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10435007  96 QYLSNSKELLEQNPGKFEELERAP---GDPKWLDV--IEKDLHRQFPFHEMFAARGGHGQQDLYRILKAYTIYRPDEGYC 170
Cdd:COG5210 223 EFLLGIGFDLDKNPGLYERLLNLHreaKIPTQEIIsqIEKDLSRTFPDNSLFQTEISIRAENLRRVLKAYSLYNPEVGYV 302
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 10435007 171 QAQAPVAAVLLMHMPAE-QAFWCLVQICDK-YLPGYYSAGLEAIQLDGEIFFALLRRASPLAHRHLRRQRIDPVLYMTEW 248
Cdd:COG5210 303 QGMNFLAAPLLLVLESEeQAFWCLVKLLKNyGLPGYFLKNLSGLHRDLKVLDDLVEELDPELYEHLLREGVVLLMFAFRW 382
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 10435007 249 FMCIFARTLPWASVLRVWDMFFCEGVKIIFRVALVLLrhtLGSVEKLRSCQGMYETMEQLRNLPQ 313
Cdd:COG5210 383 FLTLFVREFPLEYALRIWDCLFLEGSSMLFQLALAIL---KLLRDKLLKLDSDELLDLLLKQLFL 444
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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