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Conserved domains on  [gi|12835270|dbj|BAB23210|]
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unnamed protein product [Mus musculus]

Protein Classification

immunoglobulin domain-containing protein( domain architecture ID 12208967)

immunoglobulin domain-containing protein such as human platelet-derived growth factor receptor-like protein, which has been implicated in colorectal cancer and susceptibility to Behcet disease

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Ig super family cl11960
Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found ...
 278-372 3.96e-08

Immunoglobulin domain; The members here are composed of the immunoglobulin (Ig) domain found in the Ig superfamily. The Ig superfamily is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. Members of this group are components of immunoglobulin, neuroglia, cell surface glycoproteins, including T-cell receptors, CD2, CD4, CD8, and membrane glycoproteins, including butyrophilin and chondroitin sulfate proteoglycan core protein. A predominant feature of most Ig domains is a disulfide bridge connecting the two beta-sheets with a tryptophan residue packed against the disulfide bond. Ig superfamily (IgSF) domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Typically, the V-set domains have A, B, E, and D strands in one sheet and A', G, F, C, C' and C" in the other. The structures in C1-set are smaller than those in the V-set; they have one beta sheet that is formed by strands A, B, E, and D and the other by strands G, F, C, and C'. Moreover, a C1-set Ig domain contains a short C' strand (three residues) and lacks A' and C" strand. Unlike other Ig domain sets, C2-set structures do not have a D strand. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


The actual alignment was detected with superfamily member cd05742:

Pssm-ID: 472250  Cd Length: 102  Bit Score: 50.62  E-value: 3.96e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12835270 278 ASSNKVRGGDDISVLCTVLGEPDVEVEFRWLFPGQKDERPVTIQdtwRLVHRGLGHTTRISqSVIIVEDFETIDAGYYIC 357
Cdd:cd05742   9 AEPTVLPQGETLVLNCTANVNLNEVVDFQWTYPSEKEGKLALLK---PDIKVDWSEPGEFV-STLTIPEATLKDSGTYTC 84

                        90
                ....*....|....*
gi 12835270 358 TAQNLRGQTTVATTV 372
Cdd:cd05742  85 AARSGVMKKEKQTSV 99
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 83-143 3.23e-04

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


:

Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 39.03  E-value: 3.23e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 12835270     83 TVSLLAGQTLELRCKGS-----KVEWSYPAYLDTFKDSRLTVKQSERYGQLTLVNSTAADTGEFSC 143
Cdd:smart00410   3 SVTVKEGESVTLSCEASgspppEVTWYKQGGKLLAESGRFSVSRSGSTSTLTISNVTPEDSGTYTC 68
 
Name Accession Description Interval E-value
IgI_VEGFR_like cd05742
Immunoglobulin (Ig)-like domain of vascular endothelial growth factor (VEGF) receptor (R) and ...
 278-372 3.96e-08

Immunoglobulin (Ig)-like domain of vascular endothelial growth factor (VEGF) receptor (R) and similar proteins; member of the I-set of IgSF domains; The members here are composed of the immunoglobulin (Ig)-like domain of vascular endothelial growth factor (VEGF) receptor (R) and related proteins. The VEGFRs have an extracellular component with seven Ig-like domains, a transmembrane segment, and an intracellular tyrosine kinase domain interrupted by a kinase-insert domain. The VEGFR family consists of three members: VEGFR-1 (Flt-1), VEGFR-2 (KDR/Flk-1) and VEGFR-3 (Flt-4). VEGF-A interacts with both VEGFR-1 and VEGFR-2. VEGFR-1 binds strongest to VEGF; VEGF-2 binds more weakly. VEGFR-3 appears not to bind VEGF, but binds other members of the VEGF family (VEGF-C and -D). VEGFRs bind VEGFs with high affinity with the IG-like domains. VEGF-A is important to the growth and maintenance of vascular endothelial cells and to the development of new blood- and lymphatic-vessels in physiological and pathological states. VEGFR-2 is a major mediator of the mitogenic, angiogenic, and microvascular permeability-enhancing effects of VEGF-A. VEGFR-1 may play an inhibitory part in these processes by binding VEGF and interfering with its interaction with VEGFR-2. VEGFR-1 has a signaling role in mediating monocyte chemotaxis. VEGFR-1 and VEGFR-2 may mediate a chemotactic and a survival signal in hematopoietic stem cells or leukemia cells. VEGFR-3 has been shown to be involved in tumor angiogenesis and growth. This group also contains alpha-type platelet-derived growth factor receptor precursor (PDGFR)-alpha (CD140a), and PDGFR-beta (CD140b). PDGFRs alpha and beta have an extracellular component with five Ig-like domains, a transmembrane segment, and a cytoplasmic portion that has protein tyrosine kinase activity.


Pssm-ID: 409404  Cd Length: 102  Bit Score: 50.62  E-value: 3.96e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12835270 278 ASSNKVRGGDDISVLCTVLGEPDVEVEFRWLFPGQKDERPVTIQdtwRLVHRGLGHTTRISqSVIIVEDFETIDAGYYIC 357
Cdd:cd05742   9 AEPTVLPQGETLVLNCTANVNLNEVVDFQWTYPSEKEGKLALLK---PDIKVDWSEPGEFV-STLTIPEATLKDSGTYTC 84

                        90
                ....*....|....*
gi 12835270 358 TAQNLRGQTTVATTV 372
Cdd:cd05742  85 AARSGVMKKEKQTSV 99
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 271-361 2.46e-06

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 44.86  E-value: 2.46e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12835270   271 PPSTTILASSNKVRGGDDISVLCTVLGEPdvEVEFRWLFPGQKDERPVTIQDTwrlvhrglghtTRISQSVIIVEDFETI 350
Cdd:pfam13927   1 KPVITVSPSSVTVREGETVTLTCEATGSP--PPTITWYKNGEPISSGSTRSRS-----------LSGSNSTLTISNVTRS 67

                          90
                  ....*....|.
gi 12835270   351 DAGYYICTAQN 361
Cdd:pfam13927  68 DAGTYTCVASN 78
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 283-373 4.69e-05

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 41.72  E-value: 4.69e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12835270    283 VRGGDDISVLCTVLGEPDVEVEfrWLFPGQKderPVTIQDTWRLVHRGlghttriSQSVIIVEDFETIDAGYYICTAQNL 362
Cdd:smart00410   6 VKEGESVTLSCEASGSPPPEVT--WYKQGGK---LLAESGRFSVSRSG-------STSTLTISNVTPEDSGTYTCAATNS 73

                           90
                   ....*....|.
gi 12835270    363 RGQTTVATTVE 373
Cdd:smart00410  74 SGSASSGTTLT 84
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 83-143 3.23e-04

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 39.03  E-value: 3.23e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 12835270     83 TVSLLAGQTLELRCKGS-----KVEWSYPAYLDTFKDSRLTVKQSERYGQLTLVNSTAADTGEFSC 143
Cdd:smart00410   3 SVTVKEGESVTLSCEASgspppEVTWYKQGGKLLAESGRFSVSRSGSTSTLTISNVTPEDSGTYTC 68
ig pfam00047
Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of ...
 80-143 2.22e-03

Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of proteins of different functions. Examples include antibodies, the giant muscle kinase titin and receptor tyrosine kinases. Immunoglobulin-like domains may be involved in protein-protein and protein-ligand interactions.


Pssm-ID: 395002  Cd Length: 86  Bit Score: 36.79  E-value: 2.22e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 12835270    80 PAATVSLLAGQTLELRCKGS------KVEWSYPaylDTFKDSRLTVKQSERY---GQLTLVNSTAADTGEFSC 143
Cdd:pfam00047   2 APPTVTVLEGDSATLTCSAStgspgpDVTWSKE---GGTLIESLKVKHDNGRttqSSLLISNVTKEDAGTYTC 71
IgI_VEGFR cd05862
Immunoglobulin (Ig)-like domain of vascular endothelial growth factor (VEGF) receptor(R); ...
 80-144 9.11e-03

Immunoglobulin (Ig)-like domain of vascular endothelial growth factor (VEGF) receptor(R); member of the I-set of IgSF domains; The members here are composed of the immunoglobulin (Ig)-like domain of vascular endothelial growth factor (VEGF) receptor(R). The VEGFRs have an extracellular component with seven Ig-like domains, a transmembrane segment, and an intracellular tyrosine kinase domain interrupted by a kinase-insert domain. The VEGFR family consists of three members, VEGFR-1 (also known as Flt-1), VEGFR-2 (also known as KDR or Flk-1) and VEGFR-3 (also known as Flt-4). VEGF_A interacts with both VEGFR-1 and VEGFR-2. VEGFR-1 binds strongest to VEGF, VEGF-2 binds more weakly. VEGFR-3 appears not to bind VEGF, but binds other members of the VEGF family (VEGF-C and -D). VEGFRs bind VEGFs with high affinity with the IG-like domains. VEGF-A is important to the growth and maintenance of vascular endothelial cells and to the development of new blood- and lymphatic-vessels in physiological and pathological states. VEGFR-2 is a major mediator of the mitogenic, angiogenic and microvascular permeability-enhancing effects of VEGF-A. VEGFR-1 may play an inhibitory part in these processes by binding VEGF and interfering with its interaction with VEGFR-2. VEGFR-1 has a signaling role in mediating monocyte chemotaxis. VEGFR-2 and -1 may mediate a chemotactic and a survival signal in hematopoietic stem cells or leukemia cells. VEGFR-3 has been shown to be involved in tumor angiogenesis and growth.


Pssm-ID: 409448  Cd Length: 102  Bit Score: 35.50  E-value: 9.11e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12835270  80 PAATVSLLAGQTLELRCK-------GSKVEWSYPAYldtfKDSRLTVKQSERYGQ----------LTLVNSTAADTGEFS 142
Cdd:cd05862   7 PPKPVELLVGEKLVLNCTartelnvGVDFQWDYPGK----KEQRRASVRRRRKQQsseatefsstLTIDNVTLSDKGLYT 82


                ..
gi 12835270 143 CW 144
Cdd:cd05862  83 CA 84
 
Name Accession Description Interval E-value
IgI_VEGFR_like cd05742
Immunoglobulin (Ig)-like domain of vascular endothelial growth factor (VEGF) receptor (R) and ...
 278-372 3.96e-08

Immunoglobulin (Ig)-like domain of vascular endothelial growth factor (VEGF) receptor (R) and similar proteins; member of the I-set of IgSF domains; The members here are composed of the immunoglobulin (Ig)-like domain of vascular endothelial growth factor (VEGF) receptor (R) and related proteins. The VEGFRs have an extracellular component with seven Ig-like domains, a transmembrane segment, and an intracellular tyrosine kinase domain interrupted by a kinase-insert domain. The VEGFR family consists of three members: VEGFR-1 (Flt-1), VEGFR-2 (KDR/Flk-1) and VEGFR-3 (Flt-4). VEGF-A interacts with both VEGFR-1 and VEGFR-2. VEGFR-1 binds strongest to VEGF; VEGF-2 binds more weakly. VEGFR-3 appears not to bind VEGF, but binds other members of the VEGF family (VEGF-C and -D). VEGFRs bind VEGFs with high affinity with the IG-like domains. VEGF-A is important to the growth and maintenance of vascular endothelial cells and to the development of new blood- and lymphatic-vessels in physiological and pathological states. VEGFR-2 is a major mediator of the mitogenic, angiogenic, and microvascular permeability-enhancing effects of VEGF-A. VEGFR-1 may play an inhibitory part in these processes by binding VEGF and interfering with its interaction with VEGFR-2. VEGFR-1 has a signaling role in mediating monocyte chemotaxis. VEGFR-1 and VEGFR-2 may mediate a chemotactic and a survival signal in hematopoietic stem cells or leukemia cells. VEGFR-3 has been shown to be involved in tumor angiogenesis and growth. This group also contains alpha-type platelet-derived growth factor receptor precursor (PDGFR)-alpha (CD140a), and PDGFR-beta (CD140b). PDGFRs alpha and beta have an extracellular component with five Ig-like domains, a transmembrane segment, and a cytoplasmic portion that has protein tyrosine kinase activity.


Pssm-ID: 409404  Cd Length: 102  Bit Score: 50.62  E-value: 3.96e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12835270 278 ASSNKVRGGDDISVLCTVLGEPDVEVEFRWLFPGQKDERPVTIQdtwRLVHRGLGHTTRISqSVIIVEDFETIDAGYYIC 357
Cdd:cd05742   9 AEPTVLPQGETLVLNCTANVNLNEVVDFQWTYPSEKEGKLALLK---PDIKVDWSEPGEFV-STLTIPEATLKDSGTYTC 84

                        90
                ....*....|....*
gi 12835270 358 TAQNLRGQTTVATTV 372
Cdd:cd05742  85 AARSGVMKKEKQTSV 99
IgI_VEGFR cd05862
Immunoglobulin (Ig)-like domain of vascular endothelial growth factor (VEGF) receptor(R); ...
 293-372 1.03e-07

Immunoglobulin (Ig)-like domain of vascular endothelial growth factor (VEGF) receptor(R); member of the I-set of IgSF domains; The members here are composed of the immunoglobulin (Ig)-like domain of vascular endothelial growth factor (VEGF) receptor(R). The VEGFRs have an extracellular component with seven Ig-like domains, a transmembrane segment, and an intracellular tyrosine kinase domain interrupted by a kinase-insert domain. The VEGFR family consists of three members, VEGFR-1 (also known as Flt-1), VEGFR-2 (also known as KDR or Flk-1) and VEGFR-3 (also known as Flt-4). VEGF_A interacts with both VEGFR-1 and VEGFR-2. VEGFR-1 binds strongest to VEGF, VEGF-2 binds more weakly. VEGFR-3 appears not to bind VEGF, but binds other members of the VEGF family (VEGF-C and -D). VEGFRs bind VEGFs with high affinity with the IG-like domains. VEGF-A is important to the growth and maintenance of vascular endothelial cells and to the development of new blood- and lymphatic-vessels in physiological and pathological states. VEGFR-2 is a major mediator of the mitogenic, angiogenic and microvascular permeability-enhancing effects of VEGF-A. VEGFR-1 may play an inhibitory part in these processes by binding VEGF and interfering with its interaction with VEGFR-2. VEGFR-1 has a signaling role in mediating monocyte chemotaxis. VEGFR-2 and -1 may mediate a chemotactic and a survival signal in hematopoietic stem cells or leukemia cells. VEGFR-3 has been shown to be involved in tumor angiogenesis and growth.


Pssm-ID: 409448  Cd Length: 102  Bit Score: 49.75  E-value: 1.03e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12835270 293 CTVLGEPDVEVEFRWLFPGQKDERPVTIQdtwRLVHRGLGHTTRISqSVIIVEDFETIDAGYYICTAQNLRGQTTVATTV 372
Cdd:cd05862  23 CTARTELNVGVDFQWDYPGKKEQRRASVR---RRRKQQSSEATEFS-STLTIDNVTLSDKGLYTCAASSGPMFKKNSTSV 98
Ig_3 pfam13927
Immunoglobulin domain; This family contains immunoglobulin-like domains.
 271-361 2.46e-06

Immunoglobulin domain; This family contains immunoglobulin-like domains.


Pssm-ID: 464046 [Multi-domain]  Cd Length: 78  Bit Score: 44.86  E-value: 2.46e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12835270   271 PPSTTILASSNKVRGGDDISVLCTVLGEPdvEVEFRWLFPGQKDERPVTIQDTwrlvhrglghtTRISQSVIIVEDFETI 350
Cdd:pfam13927   1 KPVITVSPSSVTVREGETVTLTCEATGSP--PPTITWYKNGEPISSGSTRSRS-----------LSGSNSTLTISNVTRS 67

                          90
                  ....*....|.
gi 12835270   351 DAGYYICTAQN 361
Cdd:pfam13927  68 DAGTYTCVASN 78
I-set pfam07679
Immunoglobulin I-set domain;
272-373 2.61e-06

Immunoglobulin I-set domain;


Pssm-ID: 400151 [Multi-domain]  Cd Length: 90  Bit Score: 45.33  E-value: 2.61e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12835270   272 PSTTILASSNKVRGGDDISVLCTVLGEPDVEVEfrWLfpgqKDERPVTIQDTWRLVHRGLGHTTRISQSviivedfETID 351
Cdd:pfam07679   1 PKFTQKPKDVEVQEGESARFTCTVTGTPDPEVS--WF----KDGQPLRSSDRFKVTYEGGTYTLTISNV-------QPDD 67

                          90       100
                  ....*....|....*....|..
gi 12835270   352 AGYYICTAQNLRGQTTVATTVE 373
Cdd:pfam07679  68 SGKYTCVATNSAGEAEASAELT 89
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 283-373 4.69e-05

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 41.72  E-value: 4.69e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12835270    283 VRGGDDISVLCTVLGEPDVEVEfrWLFPGQKderPVTIQDTWRLVHRGlghttriSQSVIIVEDFETIDAGYYICTAQNL 362
Cdd:smart00410   6 VKEGESVTLSCEASGSPPPEVT--WYKQGGK---LLAESGRFSVSRSG-------STSTLTISNVTPEDSGTYTCAATNS 73

                           90
                   ....*....|.
gi 12835270    363 RGQTTVATTVE 373
Cdd:smart00410  74 SGSASSGTTLT 84
IgI_1_NCAM-2 cd05866
First immunoglobulin (Ig)-like domain of neural cell adhesion molecule NCAM-2; member of the ...
 293-372 2.09e-04

First immunoglobulin (Ig)-like domain of neural cell adhesion molecule NCAM-2; member of the I-set of Ig superfamily (IgSF) domains; The members here are composed of the first immunoglobulin (Ig)-like domain of neural cell adhesion molecule NCAM-2 (OCAM/mamFas II, RNCAM). NCAM-2 is organized similarly to NCAM-1, including five N-terminal Ig-like domains and two fibronectin type III domains. NCAM-2 is differentially expressed in the developing and mature olfactory epithelium (OE), and may function like NCAM, as an adhesion molecule. This group belongs to the I-set of IgSF domains, having A-B-E-D strands in one beta-sheet and A'-G-F-C-C' in the other. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


Pssm-ID: 409452  Cd Length: 93  Bit Score: 40.03  E-value: 2.09e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12835270 293 CTVLGEPDvevEFRWLFPgqKDERPVTIQdtwRLVHRGLGHTTRIsqsVIIVEDFEtiDAGYYICTAQNLRGQTTVATTV 372
Cdd:cd05866  22 CTAIGEPE---SIDWYNP--QGEKIVSSQ---RVVVQKEGVRSRL---TIYNANIE--DAGIYRCQATDAKGQTQEATVV 88
IG_like smart00410
Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.
 83-143 3.23e-04

Immunoglobulin like; IG domains that cannot be classified into one of IGv1, IGc1, IGc2, IG.


Pssm-ID: 214653 [Multi-domain]  Cd Length: 85  Bit Score: 39.03  E-value: 3.23e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 12835270     83 TVSLLAGQTLELRCKGS-----KVEWSYPAYLDTFKDSRLTVKQSERYGQLTLVNSTAADTGEFSC 143
Cdd:smart00410   3 SVTVKEGESVTLSCEASgspppEVTWYKQGGKLLAESGRFSVSRSGSTSTLTISNVTPEDSGTYTC 68
IgI_Myotilin_C_like cd05744
Immunoglobulin (Ig)-like domain of myotilin, palladin, and myopalladin; member of the I-set of ...
 280-370 5.44e-04

Immunoglobulin (Ig)-like domain of myotilin, palladin, and myopalladin; member of the I-set of Ig superfamily (IgSF) domains; The members here are composed of the immunoglobulin (Ig)-like domain in myotilin, palladin, and myopalladin. Myotilin, palladin, and myopalladin function as scaffolds that regulate actin organization. Myotilin and myopalladin are most abundant in skeletal and cardiac muscle; palladin is ubiquitously expressed in the organs of developing vertebrates and plays a key role in cellular morphogenesis. The three family members each interact with specific molecular partners with all three binding to alpha-actinin; In addition, palladin also binds to vasodilator-stimulated phosphoprotein (VASP) and ezrin, myotilin binds to filamin and actin, and myopalladin also binds to nebulin and cardiac ankyrin repeat protein (CARP). This group belongs to the I-set of IgSF domains, having A-B-E-D strands in one beta-sheet and A'-G-F-C-C' in the other. Like the V-set Ig domains, members of the I-set have a discontinuous A strand, but lack a C" strand.


Pssm-ID: 409405 [Multi-domain]  Cd Length: 91  Bit Score: 38.63  E-value: 5.44e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12835270 280 SNKVRGGDDISVLCTVLGEPDVEVEfrWlfpgQKDERPVTIQDTWRLVHRGLGHTTrisqsvIIVEDFETIDAGYYICTA 359
Cdd:cd05744   9 DLEVQEGRLCRFDCKVSGLPTPDLF--W----QLNGKPVRPDSAHKMLVRENGRHS------LIIEPVTKRDAGIYTCIA 76

                        90
                ....*....|.
gi 12835270 360 QNLRGQTTVAT 370
Cdd:cd05744  77 RNRAGENSFNA 87
ig pfam00047
Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of ...
 269-372 1.69e-03

Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of proteins of different functions. Examples include antibodies, the giant muscle kinase titin and receptor tyrosine kinases. Immunoglobulin-like domains may be involved in protein-protein and protein-ligand interactions.


Pssm-ID: 395002  Cd Length: 86  Bit Score: 37.17  E-value: 1.69e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12835270   269 SGPPSTTILAssnkvrgGDDISVLCTVlGEPDVEVEFRWLFPGQKDERPVTIQDTWRlvhrglghttRISQSVIIVEDFE 348
Cdd:pfam00047   1 SAPPTVTVLE-------GDSATLTCSA-STGSPGPDVTWSKEGGTLIESLKVKHDNG----------RTTQSSLLISNVT 62

                          90       100
                  ....*....|....*....|....
gi 12835270   349 TIDAGYYICTAQNLRGQTTVATTV 372
Cdd:pfam00047  63 KEDAGTYTCVVNNPGGSATLSTSL 86
ig pfam00047
Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of ...
 80-143 2.22e-03

Immunoglobulin domain; Members of the immunoglobulin superfamily are found in hundreds of proteins of different functions. Examples include antibodies, the giant muscle kinase titin and receptor tyrosine kinases. Immunoglobulin-like domains may be involved in protein-protein and protein-ligand interactions.


Pssm-ID: 395002  Cd Length: 86  Bit Score: 36.79  E-value: 2.22e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 12835270    80 PAATVSLLAGQTLELRCKGS------KVEWSYPaylDTFKDSRLTVKQSERY---GQLTLVNSTAADTGEFSC 143
Cdd:pfam00047   2 APPTVTVLEGDSATLTCSAStgspgpDVTWSKE---GGTLIESLKVKHDNGRttqSSLLISNVTKEDAGTYTC 71
IgI_titin_I1-like cd20951
Immunoglobulin domain I1 of the titin I-band and similar proteins; a member of the I-set of ...
 272-373 2.52e-03

Immunoglobulin domain I1 of the titin I-band and similar proteins; a member of the I-set of IgSF domains; The members here are composed of the immunoglobulin domain I1 of the titin I-band and similar proteins. Titin is a key component in the assembly and functioning of vertebrate striated muscles. By providing connections at the level of individual microfilaments, it contributes to the fine balance of forces between the two halves of the sarcomere. The Ig superfamily (IgSF) is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. The two sheets are linked together by a conserved disulfide bond between B strand and F strand. IgSF domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. The Ig I1 domain of the titin I-band is a member of the I-set Ig domains, having A-B-E-D strands in one beta-sheet and A'-G-F-C-C' in the other. Like the V-set Ig domains, members of the I-set have a discontinuous A strand but lack a C" strand. I-set domains are found in several cell adhesion molecules (such as VCAM, ICAM, and MADCAM), and are also present in numerous other diverse protein families, including several tyrosine-protein kinase receptors, the hemolymph protein hemolin, the muscle proteins titin, telokin, and twitchin, the neuronal adhesion molecule axonin-1, and the signaling molecule semaphorin 4D that is involved in axonal guidance, immune function and angiogenesis.


Pssm-ID: 409543 [Multi-domain]  Cd Length: 94  Bit Score: 37.02  E-value: 2.52e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12835270 272 PSTTILASSNKVRGGDDISVLCTVLGEPDVEVEfrWLFPGQKDERPVTIQDTWrlVHRGLG-HTTRISQSviiveDFEti 350
Cdd:cd20951   1 PEFIIRLQSHTVWEKSDAKLRVEVQGKPDPEVK--WYKNGVPIDPSSIPGKYK--IESEYGvHVLHIRRV-----TVE-- 69

                        90       100
                ....*....|....*....|...
gi 12835270 351 DAGYYICTAQNLRGQTTVATTVE 373
Cdd:cd20951  70 DSAVYSAVAKNIHGEASSSASVV 92
IgI_2_Titin_Z1z2-like cd20972
Second Ig-like domain of the giant muscle protein titin Z1z2 in the sarcomeric Z-disk, and ...
 271-373 3.28e-03

Second Ig-like domain of the giant muscle protein titin Z1z2 in the sarcomeric Z-disk, and similar domains; a member of the I-set of IgSF domains; The members here are composed of the second immunoglobulin (Ig)-like domain of the giant muscle protein titin Z1z2 in the sarcomeric Z-disk and similar proteins. Titin is a key component in the assembly and functioning of vertebrate striated muscles. By providing connections at the level of individual microfilaments, it contributes to the fine balance of forces between the two halves of the sarcomere. The Ig superfamily (IgSF) is a heterogenous group of proteins, built on a common fold comprised of a sandwich of two beta sheets. IgSF domains can be divided into 4 main classes based on their structures and sequences: the Variable (V), Constant 1 (C1), Constant 2 (C2), and Intermediate (I) sets. Unlike the V-set, one of the distinctive features of I-set domains is the lack of a C" strand. The structure of the titin Z1z2 lacks this strand and thus it belongs to the I-set of the IgSF. I-set domains are found in several cell adhesion molecules (such as VCAM, ICAM, and MADCAM), and are also present in numerous other diverse protein families, including several tyrosine-protein kinase receptors, the hemolymph protein hemolin, the muscle proteins titin, telokin, and twitchin, the neuronal adhesion molecule axonin-1, and the signaling molecule semaphorin 4D that is involved in axonal guidance, immune function and angiogenesis.


Pssm-ID: 409564 [Multi-domain]  Cd Length: 91  Bit Score: 36.41  E-value: 3.28e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12835270 271 PPSTTILASSNKVRGGDDISVLCTVLGEPDVEVefRWLFPGQKDERPVTIQdtwrlVHRGLGhttriSQSVIIVEDFETi 350
Cdd:cd20972   1 PPQFIQKLRSQEVAEGSKVRLECRVTGNPTPVV--RWFCEGKELQNSPDIQ-----IHQEGD-----LHSLIIAEAFEE- 67

                        90       100
                ....*....|....*....|...
gi 12835270 351 DAGYYICTAQNLRGQTTvaTTVE 373
Cdd:cd20972  68 DTGRYSCLATNSVGSDT--TSAE 88
IgI_VEGFR cd05862
Immunoglobulin (Ig)-like domain of vascular endothelial growth factor (VEGF) receptor(R); ...
 80-144 9.11e-03

Immunoglobulin (Ig)-like domain of vascular endothelial growth factor (VEGF) receptor(R); member of the I-set of IgSF domains; The members here are composed of the immunoglobulin (Ig)-like domain of vascular endothelial growth factor (VEGF) receptor(R). The VEGFRs have an extracellular component with seven Ig-like domains, a transmembrane segment, and an intracellular tyrosine kinase domain interrupted by a kinase-insert domain. The VEGFR family consists of three members, VEGFR-1 (also known as Flt-1), VEGFR-2 (also known as KDR or Flk-1) and VEGFR-3 (also known as Flt-4). VEGF_A interacts with both VEGFR-1 and VEGFR-2. VEGFR-1 binds strongest to VEGF, VEGF-2 binds more weakly. VEGFR-3 appears not to bind VEGF, but binds other members of the VEGF family (VEGF-C and -D). VEGFRs bind VEGFs with high affinity with the IG-like domains. VEGF-A is important to the growth and maintenance of vascular endothelial cells and to the development of new blood- and lymphatic-vessels in physiological and pathological states. VEGFR-2 is a major mediator of the mitogenic, angiogenic and microvascular permeability-enhancing effects of VEGF-A. VEGFR-1 may play an inhibitory part in these processes by binding VEGF and interfering with its interaction with VEGFR-2. VEGFR-1 has a signaling role in mediating monocyte chemotaxis. VEGFR-2 and -1 may mediate a chemotactic and a survival signal in hematopoietic stem cells or leukemia cells. VEGFR-3 has been shown to be involved in tumor angiogenesis and growth.


Pssm-ID: 409448  Cd Length: 102  Bit Score: 35.50  E-value: 9.11e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12835270  80 PAATVSLLAGQTLELRCK-------GSKVEWSYPAYldtfKDSRLTVKQSERYGQ----------LTLVNSTAADTGEFS 142
Cdd:cd05862   7 PPKPVELLVGEKLVLNCTartelnvGVDFQWDYPGK----KEQRRASVRRRRKQQsseatefsstLTIDNVTLSDKGLYT 82


                ..
gi 12835270 143 CW 144
Cdd:cd05862  83 CA 84
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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