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Conserved domains on  [gi|12847049|dbj|BAB27418|]
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unnamed protein product [Mus musculus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 1000017)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
SCOP:  4002744

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
38-348 1.23e-17

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 82.38  E-value: 1.23e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12847049  38 DKGGLVAVLCSNGSIRIYDKETLHLLREFGGSPGLLSGVSFANSCDSVYSASTDGTVKCWDARgaSEKPVQLFKGYpSCS 117
Cdd:cd00200  19 PDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLE--TGECVRTLTGH-TSY 95
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12847049 118 FISFDVNCKDHVICAGAekvdEDALLVFWDARFTSQDLSTRDplgaysetHSDDITQVRFHPSNpNLVVSGSTDGLVNVF 197
Cdd:cd00200  96 VSSVAFSPDGRILSSSS----RDKTIKVWDVETGKCLTTLRG--------HTDWVNSVAFSPDG-TFVASSSQDGTIKLW 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12847049 198 DLSADKeedaLVATCNS-VSSVSCIGWCGKDYKqiYCMTHDEGFCW-WDlnhLDTDEPITCLNiqdvreitdvkdGHLDY 275
Cdd:cd00200 163 DLRTGK----CVATLTGhTGEVNSVAFSPDGEK--LLSSSSDGTIKlWD---LSTGKCLGTLR------------GHENG 221
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 12847049 276 LIGGLYHEkmDRLFVIGGTNTGKIHLLSCTSAGLTHVTSlhgGHAATVRSFCWNVSEDSLLTGGEDAQLLLWK 348
Cdd:cd00200 222 VNSVAFSP--DGYLLASGSEDGTIRVWDLRTGECVQTLS---GHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
38-348 1.23e-17

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 82.38  E-value: 1.23e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12847049  38 DKGGLVAVLCSNGSIRIYDKETLHLLREFGGSPGLLSGVSFANSCDSVYSASTDGTVKCWDARgaSEKPVQLFKGYpSCS 117
Cdd:cd00200  19 PDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLE--TGECVRTLTGH-TSY 95
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12847049 118 FISFDVNCKDHVICAGAekvdEDALLVFWDARFTSQDLSTRDplgaysetHSDDITQVRFHPSNpNLVVSGSTDGLVNVF 197
Cdd:cd00200  96 VSSVAFSPDGRILSSSS----RDKTIKVWDVETGKCLTTLRG--------HTDWVNSVAFSPDG-TFVASSSQDGTIKLW 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12847049 198 DLSADKeedaLVATCNS-VSSVSCIGWCGKDYKqiYCMTHDEGFCW-WDlnhLDTDEPITCLNiqdvreitdvkdGHLDY 275
Cdd:cd00200 163 DLRTGK----CVATLTGhTGEVNSVAFSPDGEK--LLSSSSDGTIKlWD---LSTGKCLGTLR------------GHENG 221
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 12847049 276 LIGGLYHEkmDRLFVIGGTNTGKIHLLSCTSAGLTHVTSlhgGHAATVRSFCWNVSEDSLLTGGEDAQLLLWK 348
Cdd:cd00200 222 VNSVAFSP--DGYLLASGSEDGTIRVWDLRTGECVQTLS---GHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
40-349 6.03e-16

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 78.80  E-value: 6.03e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12847049  40 GGLVAVLCSNGSIRIYDKETLHLLREFGGSPGLLSGVSFANSCDSVYSASTDGTVKCWDArgASEKPVQLFKGYPSC-SF 118
Cdd:COG2319 132 GKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDL--ATGKLLRTLTGHTGAvRS 209
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12847049 119 ISFDVNCKdHVICAGaekvdEDALLVFWDarftsqdLSTRDPLGAYsETHSDDITQVRFHPSNpNLVVSGSTDGLVNVFD 198
Cdd:COG2319 210 VAFSPDGK-LLASGS-----ADGTVRLWD-------LATGKLLRTL-TGHSGSVRSVAFSPDG-RLLASGSADGTVRLWD 274
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12847049 199 LSADKEEDALVATCNSVSSVSCIGwcgkDYKQIYCMTHDEGFCWWDLnhlDTDEPITCLN--IQDVREITDVKDGHldyl 276
Cdd:COG2319 275 LATGELLRTLTGHSGGVNSVAFSP----DGKLLASGSDDGTVRLWDL---ATGKLLRTLTghTGAVRSVAFSPDGK---- 343
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 12847049 277 igglyhekmdrlFVIGGTNTGKIHLLSCTSAGLTHVTSlhgGHAATVRSFCWNVSEDSLLTGGEDAQLLLWKP 349
Cdd:COG2319 344 ------------TLASGSDDGTVRLWDLATGELLRTLT---GHTGAVTSVAFSPDGRTLASGSADGTVRLWDL 401
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
168-198 2.94e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 35.37  E-value: 2.94e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 12847049    168 HSDDITQVRFHPSNpNLVVSGSTDGLVNVFD 198
Cdd:smart00320  11 HTGPVTSVAFSPDG-KYLASGSDDGTIKLWD 40
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
38-348 1.23e-17

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 82.38  E-value: 1.23e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12847049  38 DKGGLVAVLCSNGSIRIYDKETLHLLREFGGSPGLLSGVSFANSCDSVYSASTDGTVKCWDARgaSEKPVQLFKGYpSCS 117
Cdd:cd00200  19 PDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLE--TGECVRTLTGH-TSY 95
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12847049 118 FISFDVNCKDHVICAGAekvdEDALLVFWDARFTSQDLSTRDplgaysetHSDDITQVRFHPSNpNLVVSGSTDGLVNVF 197
Cdd:cd00200  96 VSSVAFSPDGRILSSSS----RDKTIKVWDVETGKCLTTLRG--------HTDWVNSVAFSPDG-TFVASSSQDGTIKLW 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12847049 198 DLSADKeedaLVATCNS-VSSVSCIGWCGKDYKqiYCMTHDEGFCW-WDlnhLDTDEPITCLNiqdvreitdvkdGHLDY 275
Cdd:cd00200 163 DLRTGK----CVATLTGhTGEVNSVAFSPDGEK--LLSSSSDGTIKlWD---LSTGKCLGTLR------------GHENG 221
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 12847049 276 LIGGLYHEkmDRLFVIGGTNTGKIHLLSCTSAGLTHVTSlhgGHAATVRSFCWNVSEDSLLTGGEDAQLLLWK 348
Cdd:cd00200 222 VNSVAFSP--DGYLLASGSEDGTIRVWDLRTGECVQTLS---GHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
40-349 6.03e-16

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 78.80  E-value: 6.03e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12847049  40 GGLVAVLCSNGSIRIYDKETLHLLREFGGSPGLLSGVSFANSCDSVYSASTDGTVKCWDArgASEKPVQLFKGYPSC-SF 118
Cdd:COG2319 132 GKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDL--ATGKLLRTLTGHTGAvRS 209
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12847049 119 ISFDVNCKdHVICAGaekvdEDALLVFWDarftsqdLSTRDPLGAYsETHSDDITQVRFHPSNpNLVVSGSTDGLVNVFD 198
Cdd:COG2319 210 VAFSPDGK-LLASGS-----ADGTVRLWD-------LATGKLLRTL-TGHSGSVRSVAFSPDG-RLLASGSADGTVRLWD 274
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12847049 199 LSADKEEDALVATCNSVSSVSCIGwcgkDYKQIYCMTHDEGFCWWDLnhlDTDEPITCLN--IQDVREITDVKDGHldyl 276
Cdd:COG2319 275 LATGELLRTLTGHSGGVNSVAFSP----DGKLLASGSDDGTVRLWDL---ATGKLLRTLTghTGAVRSVAFSPDGK---- 343
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 12847049 277 igglyhekmdrlFVIGGTNTGKIHLLSCTSAGLTHVTSlhgGHAATVRSFCWNVSEDSLLTGGEDAQLLLWKP 349
Cdd:COG2319 344 ------------TLASGSDDGTVRLWDLATGELLRTLT---GHTGAVTSVAFSPDGRTLASGSADGTVRLWDL 401
WD40 COG2319
WD40 repeat [General function prediction only];
40-347 7.66e-13

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 69.17  E-value: 7.66e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12847049  40 GGLVAVLCSNGSIRIYDKETLHLLREFGGSPGLLSGVSFANSCDSVYSASTDGTVKCWDArgASEKPVQLFKGYPSC-SF 118
Cdd:COG2319  90 GRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDL--ATGKLLRTLTGHSGAvTS 167
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12847049 119 ISFDVNCKdHVICAGaekvdEDALLVFWdarftsqDLSTRDPLGAYSEtHSDDITQVRFHPSNpNLVVSGSTDGLVNVFD 198
Cdd:COG2319 168 VAFSPDGK-LLASGS-----DDGTVRLW-------DLATGKLLRTLTG-HTGAVRSVAFSPDG-KLLASGSADGTVRLWD 232
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12847049 199 LSADKEEDALVATCNSVSSVScigwCGKDYKQIYCMTHDEGFCWWDlnhLDTDEPITCLNIQDVReITDV---KDGHLdy 275
Cdd:COG2319 233 LATGKLLRTLTGHSGSVRSVA----FSPDGRLLASGSADGTVRLWD---LATGELLRTLTGHSGG-VNSVafsPDGKL-- 302
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 12847049 276 ligglyhekmdrlfVIGGTNTGKIHLLSCTSAGLTHVtslHGGHAATVRSFCWNVSEDSLLTGGEDAQLLLW 347
Cdd:COG2319 303 --------------LASGSDDGTVRLWDLATGKLLRT---LTGHTGAVRSVAFSPDGKTLASGSDDGTVRLW 357
WD40 COG2319
WD40 repeat [General function prediction only];
40-200 6.99e-11

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 63.39  E-value: 6.99e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12847049  40 GGLVAVLCSNGSIRIYDKETLHLLREFGGSPGLLSGVSFANSCDSVYSASTDGTVKCWDArgASEKPVQLFKGYP----S 115
Cdd:COG2319 258 GRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDL--ATGKLLRTLTGHTgavrS 335
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12847049 116 CSFiSFDvncKDHVICAGaekvdEDALLVFWDarftsqdLSTRDPLGAYSEtHSDDITQVRFHPSNpNLVVSGSTDGLVN 195
Cdd:COG2319 336 VAF-SPD---GKTLASGS-----DDGTVRLWD-------LATGELLRTLTG-HTGAVTSVAFSPDG-RTLASGSADGTVR 397

                ....*
gi 12847049 196 VFDLS 200
Cdd:COG2319 398 LWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
40-347 1.07e-07

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 53.38  E-value: 1.07e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12847049  40 GGLVAVLCSNGSIRIYDKETLHLLREFGGSPGLLSGVSFANSCDSVYSASTDGTVKCWDArgASEKPVQLFKGYPS-CSF 118
Cdd:COG2319  48 GARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDL--ATGLLLRTLTGHTGaVRS 125
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12847049 119 ISFDVNCKdHVICAGAekvdeDALLVFWdarftsqDLSTRDPLGAYSEtHSDDITQVRFHPSNpNLVVSGSTDGLVNVFD 198
Cdd:COG2319 126 VAFSPDGK-TLASGSA-----DGTVRLW-------DLATGKLLRTLTG-HSGAVTSVAFSPDG-KLLASGSDDGTVRLWD 190
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12847049 199 LSADKEEDALVATCNSVSSVScigWCGKDyKQIYCMTHDEGFCWWDlnhLDTDEPITCLNIQDvREITDV---KDGHLdy 275
Cdd:COG2319 191 LATGKLLRTLTGHTGAVRSVA---FSPDG-KLLASGSADGTVRLWD---LATGKLLRTLTGHS-GSVRSVafsPDGRL-- 260
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 12847049 276 ligglyhekmdrlfVIGGTNTGKIHLLSCTSAGLTHVTslhGGHAATVRSFCWNVSEDSLLTGGEDAQLLLW 347
Cdd:COG2319 261 --------------LASGSADGTVRLWDLATGELLRTL---TGHSGGVNSVAFSPDGKLLASGSDDGTVRLW 315
WD40 COG2319
WD40 repeat [General function prediction only];
40-101 1.30e-06

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 49.91  E-value: 1.30e-06
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 12847049  40 GGLVAVLCSNGSIRIYDKETLHLLREFGGSPGLLSGVSFANSCDSVYSASTDGTVKCWDARG 101
Cdd:COG2319 342 GKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
168-198 2.94e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 35.37  E-value: 2.94e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 12847049    168 HSDDITQVRFHPSNpNLVVSGSTDGLVNVFD 198
Cdd:smart00320  11 HTGPVTSVAFSPDG-KYLASGSDDGTIKLWD 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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