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Conserved domains on  [gi|12849534|dbj|BAB28381|]
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unnamed protein product, partial [Mus musculus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 1000017)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 37-198 6.14e-26

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 103.57  E-value: 6.14e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12849534  37 EGHTDAVLDLSWNKTvRNVLASASADSTVVLWDLSVGKSVARLTAHTDKVQTLQFHPfEAQTLISGSYDKSVALYDCRDP 116
Cdd:cd00200 132 RGHTDWVNSVAFSPD-GTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSP-DGEKLLSSSSDGTIKLWDLSTG 209

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12849534 117 SQNHrqwRFSGQIERVTWNHFSPCH--FLASTDDGFVYNLDARSDKPIFTLNAHNDEISGLDLSSQIKgCLVTASADKFV 194
Cdd:cd00200 210 KCLG---TLRGHENGVNSVAFSPDGylLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGK-RLASGSADGTI 285


                ....
gi 12849534 195 KIWD 198
Cdd:cd00200 286 RIWD 289
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 37-198 6.14e-26

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 103.57  E-value: 6.14e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12849534  37 EGHTDAVLDLSWNKTvRNVLASASADSTVVLWDLSVGKSVARLTAHTDKVQTLQFHPfEAQTLISGSYDKSVALYDCRDP 116
Cdd:cd00200 132 RGHTDWVNSVAFSPD-GTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSP-DGEKLLSSSSDGTIKLWDLSTG 209

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12849534 117 SQNHrqwRFSGQIERVTWNHFSPCH--FLASTDDGFVYNLDARSDKPIFTLNAHNDEISGLDLSSQIKgCLVTASADKFV 194
Cdd:cd00200 210 KCLG---TLRGHENGVNSVAFSPDGylLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGK-RLASGSADGTI 285


                ....
gi 12849534 195 KIWD 198
Cdd:cd00200 286 RIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
37-246 1.25e-23

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 99.22  E-value: 1.25e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12849534  37 EGHTDAVLDLSWN---KTvrnvLASASADSTVVLWDLSVGKSVARLTAHTDKVQTLQFHPfEAQTLISGSYDKSVALYDC 113
Cdd:COG2319 117 TGHTGAVRSVAFSpdgKT----LASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSP-DGKLLASGSDDGTVRLWDL 191

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12849534 114 RDPSQnhrQWRFSGQIERVTWNHFSPC-HFLAS-TDDGFVYNLDARSDKPIFTLNAHNDEISGLDLS--SQIkgcLVTAS 189
Cdd:COG2319 192 ATGKL---LRTLTGHTGAVRSVAFSPDgKLLASgSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSpdGRL---LASGS 265

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 12849534 190 ADKFVKIWDIlgDRPSLIHSRDMKMGVLFCSSCCPDLPLVyAFGGQKEGLRVWDIST 246
Cdd:COG2319 266 ADGTVRLWDL--ATGELLRTLTGHSGGVNSVAFSPDGKLL-ASGSDDGTVRLWDLAT 319
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 46-254 1.05e-07

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 52.78  E-value: 1.05e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12849534   46 LSWNKTVRNVLASASADSTVVLWDLSVGKSVARLTAHTDKVQTLQFHPFEAQTLISGSYDKSVALYDCRD---------- 115
Cdd:PLN00181 538 ICWNSYIKSQVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSADPTLLASGSDDGSVKLWSINQgvsigtiktk 617

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12849534  116 --------PSQNHRQWRFsgqiervtwnhfspchflaSTDDGFVYNLDARSDK-PIFTLNAHNDEISGLDLSSQikGCLV 186
Cdd:PLN00181 618 aniccvqfPSESGRSLAF-------------------GSADHKVYYYDLRNPKlPLCTMIGHSKTVSYVRFVDS--STLV 676

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 12849534  187 TASADKFVKIWdilgdrpslihsrDMKMGVlfcsSCCPDLPLvYAFGGQKE-----GLRVWD--ISTVSSVNEAF 254
Cdd:PLN00181 677 SSSTDNTLKLW-------------DLSMSI----SGINETPL-HSFMGHTNvknfvGLSVSDgyIATGSETNEVF 733
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 158-198 1.45e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.45  E-value: 1.45e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 12849534    158 SDKPIFTLNAHNDEISGLDLSSQIKgCLVTASADKFVKIWD 198
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGK-YLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
37-69 1.25e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.78  E-value: 1.25e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 12849534    37 EGHTDAVLDLSWNKTvRNVLASASADSTVVLWD 69
Cdd:pfam00400   8 EGHTGSVTSLAFSPD-GKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 37-198 6.14e-26

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 103.57  E-value: 6.14e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12849534  37 EGHTDAVLDLSWNKTvRNVLASASADSTVVLWDLSVGKSVARLTAHTDKVQTLQFHPfEAQTLISGSYDKSVALYDCRDP 116
Cdd:cd00200 132 RGHTDWVNSVAFSPD-GTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSP-DGEKLLSSSSDGTIKLWDLSTG 209

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12849534 117 SQNHrqwRFSGQIERVTWNHFSPCH--FLASTDDGFVYNLDARSDKPIFTLNAHNDEISGLDLSSQIKgCLVTASADKFV 194
Cdd:cd00200 210 KCLG---TLRGHENGVNSVAFSPDGylLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGK-RLASGSADGTI 285


                ....
gi 12849534 195 KIWD 198
Cdd:cd00200 286 RIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
37-246 1.25e-23

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 99.22  E-value: 1.25e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12849534  37 EGHTDAVLDLSWN---KTvrnvLASASADSTVVLWDLSVGKSVARLTAHTDKVQTLQFHPfEAQTLISGSYDKSVALYDC 113
Cdd:COG2319 117 TGHTGAVRSVAFSpdgKT----LASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSP-DGKLLASGSDDGTVRLWDL 191

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12849534 114 RDPSQnhrQWRFSGQIERVTWNHFSPC-HFLAS-TDDGFVYNLDARSDKPIFTLNAHNDEISGLDLS--SQIkgcLVTAS 189
Cdd:COG2319 192 ATGKL---LRTLTGHTGAVRSVAFSPDgKLLASgSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSpdGRL---LASGS 265

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 12849534 190 ADKFVKIWDIlgDRPSLIHSRDMKMGVLFCSSCCPDLPLVyAFGGQKEGLRVWDIST 246
Cdd:COG2319 266 ADGTVRLWDL--ATGELLRTLTGHSGGVNSVAFSPDGKLL-ASGSDDGTVRLWDLAT 319
WD40 COG2319
WD40 repeat [General function prediction only];
37-246 1.28e-23

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 99.22  E-value: 1.28e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12849534  37 EGHTDAVLDLSWNKTvRNVLASASADSTVVLWDLSVGKSVARLTAHTDKVQTLQFHPfEAQTLISGSYDKSVALYDCRDP 116
Cdd:COG2319 159 TGHSGAVTSVAFSPD-GKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP-DGKLLASGSADGTVRLWDLATG 236

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12849534 117 SQNHRQWRFSGQIERVTwnhFSP-CHFLAST-DDGFVYNLDARSDKPIFTLNAHNDEISGLDLS--SQIkgcLVTASADK 192
Cdd:COG2319 237 KLLRTLTGHSGSVRSVA---FSPdGRLLASGsADGTVRLWDLATGELLRTLTGHSGGVNSVAFSpdGKL---LASGSDDG 310

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....
gi 12849534 193 FVKIWDIlgDRPSLIHSRDMKMGVLFCSSCCPDLPLVyAFGGQKEGLRVWDIST 246
Cdd:COG2319 311 TVRLWDL--ATGKLLRTLTGHTGAVRSVAFSPDGKTL-ASGSDDGTVRLWDLAT 361
WD40 COG2319
WD40 repeat [General function prediction only];
36-246 1.49e-22

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 96.13  E-value: 1.49e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12849534  36 AEGHTDAVLDLSWNKTVRnVLASASADSTVVLWDLSVGKSVARLTAHTDKVQTLQFHPfEAQTLISGSYDKSVALYdcrD 115
Cdd:COG2319  74 LLGHTAAVLSVAFSPDGR-LLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSP-DGKTLASGSADGTVRLW---D 148

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12849534 116 PSQNHRQWRFSGQIERVTWNHFSP-CHFLAST-DDGFVYNLDARSDKPIFTLNAHNDEISGLDLS--SQIkgcLVTASAD 191
Cdd:COG2319 149 LATGKLLRTLTGHSGAVTSVAFSPdGKLLASGsDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSpdGKL---LASGSAD 225

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 12849534 192 KFVKIWDILGDRP--SLIHSRDMKMGVLFcsscCPDLPLVyAFGGQKEGLRVWDIST 246
Cdd:COG2319 226 GTVRLWDLATGKLlrTLTGHSGSVRSVAF----SPDGRLL-ASGSADGTVRLWDLAT 277
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 37-270 1.74e-22

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 94.32  E-value: 1.74e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12849534  37 EGHTDAVLDLSWNkTVRNVLASASADSTVVLWDLSVGKSVARLTAHTDKVQTLQFHPFeAQTLISGSYDKSVALYdcrDP 116
Cdd:cd00200   6 KGHTGGVTCVAFS-PDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASAD-GTYLASGSSDKTIRLW---DL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12849534 117 SQNHRQWRFSGQIERVTWNHFSPCHFLAST--DDGFVYNLDARSDKPIFTLNAHNDEISGLDLSSQiKGCLVTASADKFV 194
Cdd:cd00200  81 ETGECVRTLTGHTSYVSSVAFSPDGRILSSssRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPD-GTFVASSSQDGTI 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12849534 195 KIWDIlgDRPSLIHSRDMKMGVLFCSSCCPDLPLVYAFGGQKEgLRVWDISTVSSVNE-----------AFGRRERLVIG 263
Cdd:cd00200 160 KLWDL--RTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGT-IKLWDLSTGKCLGTlrghengvnsvAFSPDGYLLAS 236


                ....*..
gi 12849534 264 GTKGLSV 270
Cdd:cd00200 237 GSEDGTI 243
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 37-243 4.05e-22

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 93.17  E-value: 4.05e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12849534  37 EGHTDAVLDLSWNKTvRNVLASASADSTVVLWDLSVGKSVARLTAHTDKVQTLQFHPFEaQTLISGSYDKSVALYdcrDP 116
Cdd:cd00200  90 TGHTSYVSSVAFSPD-GRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDG-TFVASSSQDGTIKLW---DL 164

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12849534 117 SQNHRQWRFSGQIERVTWNHFSP--CHFLASTDDGFVYNLDARSDKPIFTLNAHNDEISGLDLSSQiKGCLVTASADKFV 194
Cdd:cd00200 165 RTGKCVATLTGHTGEVNSVAFSPdgEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPD-GYLLASGSEDGTI 243

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|..
gi 12849534 195 KIWDILGDRPSLI---HSRDmkmgvLFCSSCCPDLPLVYAfGGQKEGLRVWD 243
Cdd:cd00200 244 RVWDLRTGECVQTlsgHTNS-----VTSLAWSPDGKRLAS-GSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 37-255 4.67e-22

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 93.17  E-value: 4.67e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12849534  37 EGHTDAVLDLSWNKtVRNVLASASADSTVVLWDLSVGKSVARLTAHTDKVQTLQFHPfEAQTLISGSYDKSVALYD---- 112
Cdd:cd00200  48 KGHTGPVRDVAASA-DGTYLASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSP-DGRILSSSSRDKTIKVWDvetg 125

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12849534 113 -CRDPSQNHRQWrfsgqIERVTWNHFSpcHFLA-STDDGFVYNLDARSDKPIFTLNAHNDEISGLDLSSQiKGCLVTASA 190
Cdd:cd00200 126 kCLTTLRGHTDW-----VNSVAFSPDG--TFVAsSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPD-GEKLLSSSS 197

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 12849534 191 DKFVKIWDILGDRPS-LIHSRDMkmgvlFCSSCCPDLPLVYAFGGQKEG-LRVWDISTVSSVNEAFG 255
Cdd:cd00200 198 DGTIKLWDLSTGKCLgTLRGHEN-----GVNSVAFSPDGYLLASGSEDGtIRVWDLRTGECVQTLSG 259
WD40 COG2319
WD40 repeat [General function prediction only];
37-199 6.39e-21

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 91.51  E-value: 6.39e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12849534  37 EGHTDAVLDLSWNKTvRNVLASASADSTVVLWDLSVGKSVARLTAHTDKVQTLQFHPfEAQTLISGSYDKSVALYDcrdP 116
Cdd:COG2319 243 TGHSGSVRSVAFSPD-GRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSP-DGKLLASGSDDGTVRLWD---L 317

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12849534 117 SQNHRQWRFSGQIERVTWNHFSPC-HFLAS-TDDGFVYNLDARSDKPIFTLNAHNDEISGLDLSSQIKgCLVTASADKFV 194
Cdd:COG2319 318 ATGKLLRTLTGHTGAVRSVAFSPDgKTLASgSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGR-TLASGSADGTV 396


                ....*
gi 12849534 195 KIWDI 199
Cdd:COG2319 397 RLWDL 401
WD40 COG2319
WD40 repeat [General function prediction only];
36-246 1.05e-16

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 79.18  E-value: 1.05e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12849534  36 AEGHTDAVLDLSWNkTVRNVLASASADSTVVLWDLSVGKSVARLTAHTDKVQTLQFHPfEAQTLISGSYDKSVALYDCRD 115
Cdd:COG2319  32 LLGLAAAVASLAAS-PDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSP-DGRLLASASADGTVRLWDLAT 109

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12849534 116 PSQNHRQWRFSGQIERVTwnhFSP-CHFLAST-DDGFVYNLDARSDKPIFTLNAHNDEISGLDLS--SQIkgcLVTASAD 191
Cdd:COG2319 110 GLLLRTLTGHTGAVRSVA---FSPdGKTLASGsADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSpdGKL---LASGSDD 183

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*
gi 12849534 192 KFVKIWDILGDRpsLIHSRDMKMGVLFCSSCCPDLPLVyAFGGQKEGLRVWDIST 246
Cdd:COG2319 184 GTVRLWDLATGK--LLRTLTGHTGAVRSVAFSPDGKLL-ASGSADGTVRLWDLAT 235
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 75-199 1.06e-12

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 66.59  E-value: 1.06e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12849534  75 SVARLTAHTDKVQTLQFHPfEAQTLISGSYDKSVALYDCRDPSQNHRQWRFSGQIERVTWNHFSPChFLASTDDGFVYNL 154
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSP-DGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTY-LASGSSDKTIRLW 78

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 12849534 155 DARSDKPIFTLNAHNDEISGLDLSSQIKgCLVTASADKFVKIWDI 199
Cdd:cd00200  79 DLETGECVRTLTGHTSYVSSVAFSPDGR-ILSSSSRDKTIKVWDV 122
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 46-254 1.05e-07

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 52.78  E-value: 1.05e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12849534   46 LSWNKTVRNVLASASADSTVVLWDLSVGKSVARLTAHTDKVQTLQFHPFEAQTLISGSYDKSVALYDCRD---------- 115
Cdd:PLN00181 538 ICWNSYIKSQVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSADPTLLASGSDDGSVKLWSINQgvsigtiktk 617

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12849534  116 --------PSQNHRQWRFsgqiervtwnhfspchflaSTDDGFVYNLDARSDK-PIFTLNAHNDEISGLDLSSQikGCLV 186
Cdd:PLN00181 618 aniccvqfPSESGRSLAF-------------------GSADHKVYYYDLRNPKlPLCTMIGHSKTVSYVRFVDS--STLV 676

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 12849534  187 TASADKFVKIWdilgdrpslihsrDMKMGVlfcsSCCPDLPLvYAFGGQKE-----GLRVWD--ISTVSSVNEAF 254
Cdd:PLN00181 677 SSSTDNTLKLW-------------DLSMSI----SGINETPL-HSFMGHTNvknfvGLSVSDgyIATGSETNEVF 733
PTZ00421 PTZ00421
coronin; Provisional
 37-115 1.14e-07

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 52.59  E-value: 1.14e-07
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 12849534   37 EGHTDAVLDLSWNKTVRNVLASASADSTVVLWDLSVGKSVARLTAHTDKVQTLQFHpFEAQTLISGSYDKSVALYDCRD 115
Cdd:PTZ00421 122 QGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVERGKAVEVIKCHSDQITSLEWN-LDGSLLCTTSKDKKLNIIDPRD 199
PTZ00420 PTZ00420
coronin; Provisional
 37-112 6.65e-07

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 50.33  E-value: 6.65e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12849534   37 EGHTDAVLDLSWNKTVRNVLASASADSTVVLWDL--------SVGKSVARLTAHTDKVQTLQFHPFEAQTLISGSYDKSV 108
Cdd:PTZ00420  71 KGHTSSILDLQFNPCFSEILASGSEDLTIRVWEIphndesvkEIKDPQCILKGHKKKISIIDWNPMNYYIMCSSGFDSFV 150


                 ....
gi 12849534  109 ALYD 112
Cdd:PTZ00420 151 NIWD 154
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 158-198 1.45e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.45  E-value: 1.45e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 12849534    158 SDKPIFTLNAHNDEISGLDLSSQIKgCLVTASADKFVKIWD 198
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGK-YLASGSDDGTIKLWD 40
PTZ00421 PTZ00421
coronin; Provisional
 38-238 1.62e-04

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 42.96  E-value: 1.62e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12849534   38 GHTDAVLDLSWNKTVRNVLASASADSTVVLWDL-------SVGKSVARLTAHTDKVQTLQFHPFEAQTLISGSYDKSVAL 110
Cdd:PTZ00421  73 GQEGPIIDVAFNPFDPQKLFTASEDGTIMGWGIpeegltqNISDPIVHLQGHTKKVGIVSFHPSAMNVLASAGADMVVNV 152

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12849534  111 YDCRDPSQNHRQWRFSGQIERVTWNhFSPCHFLASTDDGFVYNLDARSDKPIFTLNAHNDEISGLDLSSQIKGCLVTASA 190
Cdd:PTZ00421 153 WDVERGKAVEVIKCHSDQITSLEWN-LDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHASAKSQRCLWAKRKDLIITLGC 231

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 12849534  191 DKF----VKIWDILgDRPSLIHSRDMKMgvlFCSSCCP----DLPLVYaFGGQKEG 238
Cdd:PTZ00421 232 SKSqqrqIMLWDTR-KMASPYSTVDLDQ---SSALFIPffdeDTNLLY-IGSKGEG 282
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 37-69 2.13e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.06  E-value: 2.13e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 12849534     37 EGHTDAVLDLSWNKTvRNVLASASADSTVVLWD 69
Cdd:smart00320   9 KGHTGPVTSVAFSPD-GKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 73-112 4.60e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.91  E-value: 4.60e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 12849534     73 GKSVARLTAHTDKVQTLQFHPFEaQTLISGSYDKSVALYD 112
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPDG-KYLASGSDDGTIKLWD 40
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 39-116 5.32e-04

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 41.23  E-value: 5.32e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 12849534   39 HTDAVLDLSWNKTVRNVLASASADSTVVLWDLSVGKSVARLTAHTDkVQTLQFHPFEAQTLISGSYDKSVALYDCRDP 116
Cdd:PLN00181 574 HEKRVWSIDYSSADPTLLASGSDDGSVKLWSINQGVSIGTIKTKAN-ICCVQFPSESGRSLAFGSADHKVYYYDLRNP 650
WD40 pfam00400
WD domain, G-beta repeat;
37-69 1.25e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.78  E-value: 1.25e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 12849534    37 EGHTDAVLDLSWNKTvRNVLASASADSTVVLWD 69
Cdd:pfam00400   8 EGHTGSVTSLAFSPD-GKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
73-112 1.82e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.40  E-value: 1.82e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 12849534    73 GKSVARLTAHTDKVQTLQFHPfEAQTLISGSYDKSVALYD 112
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSP-DGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
160-198 1.93e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.40  E-value: 1.93e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 12849534   160 KPIFTLNAHNDEISGLDLSSQiKGCLVTASADKFVKIWD 198
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPD-GKLLASGSDDGTVKVWD 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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