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Conserved domains on  [gi|12857393|dbj|BAB30997|]
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unnamed protein product [Mus musculus]

Protein Classification

TCR_zetazeta and ITAM domain-containing protein( domain architecture ID 10569225)

TCR_zetazeta and ITAM domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TCR_zetazeta pfam11628
T-cell surface glycoprotein CD3 zeta chain; The incorporation of the zetazeta signalling ...
 28-58 5.22e-16

T-cell surface glycoprotein CD3 zeta chain; The incorporation of the zetazeta signalling module requires one basic TCR alpha and two zetazeta aspartic acid TM residues. The structure of the zetazeta(TM) dimer consists of a left-handed coiled coil with polar contacts. Two aspartic acids are critical for zetazeta dimerization and assembly with TCR.


:

Pssm-ID: 463313  Cd Length: 31  Bit Score: 67.34  E-value: 5.22e-16
                          10        20        30
                  ....*....|....*....|....*....|.
gi 12857393    28 DPKLCYLLDGILFIYGVIITALYLRAKFSRS 58
Cdd:pfam11628   1 DPRLCYILDGILFIYGIIITALFCREKFSKS 31
ITAM super family cl02452
Immunoreceptor tyrosine-based activation motif; Motif that may be dually phosphorylated on ...
 69-89 5.15e-04

Immunoreceptor tyrosine-based activation motif; Motif that may be dually phosphorylated on tyrosine that links antigen receptors to downstream signalling machinery.


The actual alignment was detected with superfamily member smart00077:

Pssm-ID: 128390  Cd Length: 21  Bit Score: 35.82  E-value: 5.15e-04
                           10        20
                   ....*....|....*....|.
gi 12857393     69 NQLYNELNLGRREEYDVLEKK 89
Cdd:smart00077   1 DQLYQPLNKRQRDTYSDLNTR 21
 
Name Accession Description Interval E-value
TCR_zetazeta pfam11628
T-cell surface glycoprotein CD3 zeta chain; The incorporation of the zetazeta signalling ...
 28-58 5.22e-16

T-cell surface glycoprotein CD3 zeta chain; The incorporation of the zetazeta signalling module requires one basic TCR alpha and two zetazeta aspartic acid TM residues. The structure of the zetazeta(TM) dimer consists of a left-handed coiled coil with polar contacts. Two aspartic acids are critical for zetazeta dimerization and assembly with TCR.


Pssm-ID: 463313  Cd Length: 31  Bit Score: 67.34  E-value: 5.22e-16
                          10        20        30
                  ....*....|....*....|....*....|.
gi 12857393    28 DPKLCYLLDGILFIYGVIITALYLRAKFSRS 58
Cdd:pfam11628   1 DPRLCYILDGILFIYGIIITALFCREKFSKS 31
ITAM smart00077
Immunoreceptor tyrosine-based activation motif; Motif that may be dually phosphorylated on ...
 69-89 5.15e-04

Immunoreceptor tyrosine-based activation motif; Motif that may be dually phosphorylated on tyrosine that links antigen receptors to downstream signalling machinery.


Pssm-ID: 128390  Cd Length: 21  Bit Score: 35.82  E-value: 5.15e-04
                           10        20
                   ....*....|....*....|.
gi 12857393     69 NQLYNELNLGRREEYDVLEKK 89
Cdd:smart00077   1 DQLYQPLNKRQRDTYSDLNTR 21
 
Name Accession Description Interval E-value
TCR_zetazeta pfam11628
T-cell surface glycoprotein CD3 zeta chain; The incorporation of the zetazeta signalling ...
 28-58 5.22e-16

T-cell surface glycoprotein CD3 zeta chain; The incorporation of the zetazeta signalling module requires one basic TCR alpha and two zetazeta aspartic acid TM residues. The structure of the zetazeta(TM) dimer consists of a left-handed coiled coil with polar contacts. Two aspartic acids are critical for zetazeta dimerization and assembly with TCR.


Pssm-ID: 463313  Cd Length: 31  Bit Score: 67.34  E-value: 5.22e-16
                          10        20        30
                  ....*....|....*....|....*....|.
gi 12857393    28 DPKLCYLLDGILFIYGVIITALYLRAKFSRS 58
Cdd:pfam11628   1 DPRLCYILDGILFIYGIIITALFCREKFSKS 31
ITAM smart00077
Immunoreceptor tyrosine-based activation motif; Motif that may be dually phosphorylated on ...
 69-89 5.15e-04

Immunoreceptor tyrosine-based activation motif; Motif that may be dually phosphorylated on tyrosine that links antigen receptors to downstream signalling machinery.


Pssm-ID: 128390  Cd Length: 21  Bit Score: 35.82  E-value: 5.15e-04
                           10        20
                   ....*....|....*....|.
gi 12857393     69 NQLYNELNLGRREEYDVLEKK 89
Cdd:smart00077   1 DQLYQPLNKRQRDTYSDLNTR 21
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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