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Conserved domains on  [gi|12861535|dbj|BAB32221|]
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unnamed protein product [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TSP1_ADAMTS super family cl40597
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 36-86 1.03e-08

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


The actual alignment was detected with superfamily member pfam19030:

Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 48.22  E-value: 1.03e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 12861535    36 WYTSPWSECTKTCGVGVRMRDVKCYQ--GTDIVRG--CDPLVKPVGRQACDLQPC 86
Cdd:pfam19030   1 WVAGPWGECSVTCGGGVQTRLVQCVQkgGGSIVPDseCSAQKKPPETQSCNLKPC 55
PLAC pfam08686
PLAC (protease and lacunin) domain; The PLAC (protease and lacunin) domain is a short ...
 95-126 6.70e-07

PLAC (protease and lacunin) domain; The PLAC (protease and lacunin) domain is a short six-cysteine region that is usually found at the C terminal of proteins. It is found in a range of proteins including PACE4 (paired basic amino acid cleaving enzyme 4) and the extracellular matrix protein lacunin.


:

Pssm-ID: 462560  Cd Length: 31  Bit Score: 42.91  E-value: 6.70e-07
                          10        20        30
                  ....*....|....*....|....*....|..
gi 12861535    95 CQDQpGTNCALAIKANLCGHWYYSKACCRSCR 126
Cdd:pfam08686   1 CKDK-FANCSLVVQARLCSHKYYRQFCCRSCS 31
 
Name Accession Description Interval E-value
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 36-86 1.03e-08

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 48.22  E-value: 1.03e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 12861535    36 WYTSPWSECTKTCGVGVRMRDVKCYQ--GTDIVRG--CDPLVKPVGRQACDLQPC 86
Cdd:pfam19030   1 WVAGPWGECSVTCGGGVQTRLVQCVQkgGGSIVPDseCSAQKKPPETQSCNLKPC 55
PLAC pfam08686
PLAC (protease and lacunin) domain; The PLAC (protease and lacunin) domain is a short ...
 95-126 6.70e-07

PLAC (protease and lacunin) domain; The PLAC (protease and lacunin) domain is a short six-cysteine region that is usually found at the C terminal of proteins. It is found in a range of proteins including PACE4 (paired basic amino acid cleaving enzyme 4) and the extracellular matrix protein lacunin.


Pssm-ID: 462560  Cd Length: 31  Bit Score: 42.91  E-value: 6.70e-07
                          10        20        30
                  ....*....|....*....|....*....|..
gi 12861535    95 CQDQpGTNCALAIKANLCGHWYYSKACCRSCR 126
Cdd:pfam08686   1 CKDK-FANCSLVVQARLCSHKYYRQFCCRSCS 31
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 38-87 2.71e-04

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 36.41  E-value: 2.71e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 12861535     38 TSPWSECTKTCGVGVRMRDVKCYQGTDIVRGCDPLVKPVGRQACDLQPCP 87
Cdd:smart00209   4 WSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCTGEDVETRACNEQPCP 53
 
Name Accession Description Interval E-value
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 36-86 1.03e-08

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 48.22  E-value: 1.03e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 12861535    36 WYTSPWSECTKTCGVGVRMRDVKCYQ--GTDIVRG--CDPLVKPVGRQACDLQPC 86
Cdd:pfam19030   1 WVAGPWGECSVTCGGGVQTRLVQCVQkgGGSIVPDseCSAQKKPPETQSCNLKPC 55
PLAC pfam08686
PLAC (protease and lacunin) domain; The PLAC (protease and lacunin) domain is a short ...
 95-126 6.70e-07

PLAC (protease and lacunin) domain; The PLAC (protease and lacunin) domain is a short six-cysteine region that is usually found at the C terminal of proteins. It is found in a range of proteins including PACE4 (paired basic amino acid cleaving enzyme 4) and the extracellular matrix protein lacunin.


Pssm-ID: 462560  Cd Length: 31  Bit Score: 42.91  E-value: 6.70e-07
                          10        20        30
                  ....*....|....*....|....*....|..
gi 12861535    95 CQDQpGTNCALAIKANLCGHWYYSKACCRSCR 126
Cdd:pfam08686   1 CKDK-FANCSLVVQARLCSHKYYRQFCCRSCS 31
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 38-87 2.71e-04

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 36.41  E-value: 2.71e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 12861535     38 TSPWSECTKTCGVGVRMRDVKCYQGTDIVRGCDPLVKPVGRQACDLQPCP 87
Cdd:smart00209   4 WSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCTGEDVETRACNEQPCP 53
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 39-55 7.32e-03

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 32.64  E-value: 7.32e-03
                          10
                  ....*....|....*..
gi 12861535    39 SPWSECTKTCGVGVRMR 55
Cdd:pfam19028   7 SEWSECSVTCGGGVQTR 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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