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Conserved domains on  [gi|13700665|dbj|BAB41962|]
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triosephosphate isomerase [Staphylococcus aureus subsp. aureus N315]

Protein Classification

triose-phosphate isomerase( domain architecture ID 10791623)

triose-phosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion between dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate

CATH:  3.20.20.70
EC:  5.3.1.1
Gene Ontology:  GO:0004807|GO:0006096|GO:0031625|GO:0042803
PubMed:  12206759|11257493
SCOP:  4003038

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
tpiA PRK00042
triosephosphate isomerase; Provisional
 2-253 8.04e-148

triosephosphate isomerase; Provisional


:

Pssm-ID: 234589  Cd Length: 250  Bit Score: 412.59  E-value: 8.04e-148
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13700665    2 RTPIIAGNWKMNKTVQEAKDFVNAL-PTLPDSKEVESVICAPAIQLDALTTAVKegkAQGLEIGAQNTYFEDNGAFTGET 80
Cdd:PRK00042   1 RKPIIAGNWKMNKTLAEAKALVEELkAALPDADGVEVAVAPPFTALASVKEALK---GSNIKLGAQNVHPEDSGAFTGEI 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13700665   81 SPVALADLGVKYVVIGHSERRELFHETDEEINKKAHAIFKHGMTPIICVGETDEERESGKANDVVGEQVKKAVAGLSEDQ 160
Cdd:PRK00042  78 SAEMLKDLGVKYVIIGHSERRQYFGETDELVNKKVKAALKAGLTPILCVGETLEEREAGKTEEVVARQLEAALAGLSAEQ 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13700665  161 LKSVVIAYEPIWAIGTGKSSTSEDANEMCAFVRQTIADLSSkEVSEATRIQYGGSVKPNNIKEYMAQTDIDGALVGGASL 240
Cdd:PRK00042 158 FANLVIAYEPVWAIGTGKTATPEQAQEVHAFIRAVLAELYG-EVAEKVRILYGGSVKPDNAAELMAQPDIDGALVGGASL 236

                        250
                 ....*....|...
gi 13700665  241 KVEDFVQLLEGAK 253
Cdd:PRK00042 237 KAEDFLAIVKAAA 249
 
Name Accession Description Interval E-value
tpiA PRK00042
triosephosphate isomerase; Provisional
 2-253 8.04e-148

triosephosphate isomerase; Provisional


Pssm-ID: 234589  Cd Length: 250  Bit Score: 412.59  E-value: 8.04e-148
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13700665    2 RTPIIAGNWKMNKTVQEAKDFVNAL-PTLPDSKEVESVICAPAIQLDALTTAVKegkAQGLEIGAQNTYFEDNGAFTGET 80
Cdd:PRK00042   1 RKPIIAGNWKMNKTLAEAKALVEELkAALPDADGVEVAVAPPFTALASVKEALK---GSNIKLGAQNVHPEDSGAFTGEI 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13700665   81 SPVALADLGVKYVVIGHSERRELFHETDEEINKKAHAIFKHGMTPIICVGETDEERESGKANDVVGEQVKKAVAGLSEDQ 160
Cdd:PRK00042  78 SAEMLKDLGVKYVIIGHSERRQYFGETDELVNKKVKAALKAGLTPILCVGETLEEREAGKTEEVVARQLEAALAGLSAEQ 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13700665  161 LKSVVIAYEPIWAIGTGKSSTSEDANEMCAFVRQTIADLSSkEVSEATRIQYGGSVKPNNIKEYMAQTDIDGALVGGASL 240
Cdd:PRK00042 158 FANLVIAYEPVWAIGTGKTATPEQAQEVHAFIRAVLAELYG-EVAEKVRILYGGSVKPDNAAELMAQPDIDGALVGGASL 236

                        250
                 ....*....|...
gi 13700665  241 KVEDFVQLLEGAK 253
Cdd:PRK00042 237 KAEDFLAIVKAAA 249
TpiA COG0149
Triosephosphate isomerase [Carbohydrate transport and metabolism]; Triosephosphate isomerase ...
 1-250 1.86e-147

Triosephosphate isomerase [Carbohydrate transport and metabolism]; Triosephosphate isomerase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 439919 [Multi-domain]  Cd Length: 249  Bit Score: 411.76  E-value: 1.86e-147
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13700665   1 MRTPIIAGNWKMNKTVQEAKDFVNAL-PTLPDSKEVESVICAPAIQLDALTTAVKEGkaqGLEIGAQNTYFEDNGAFTGE 79
Cdd:COG0149   1 MRKPLIAGNWKMNGTLAEAKALLAALaAALADLADVEVVVCPPFTYLAAVAEALAGS---PIALGAQNVHWEDSGAYTGE 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13700665  80 TSPVALADLGVKYVVIGHSERRELFHETDEEINKKAHAIFKHGMTPIICVGETDEERESGKANDVVGEQVKKAVAGLSED 159
Cdd:COG0149  78 ISAAMLKDLGCRYVIVGHSERRQYFGETDELVNKKVKAALAAGLTPILCVGETLEEREAGKTEEVVARQLKAALAGLSAE 157

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13700665 160 QLKSVVIAYEPIWAIGTGKSSTSEDANEMCAFVRQTIADLSSKEVSEATRIQYGGSVKPNNIKEYMAQTDIDGALVGGAS 239
Cdd:COG0149 158 QAANVVIAYEPVWAIGTGKTATPEQAQEVHAFIRALLAELYGAEVAEAVRILYGGSVKPGNAAELFAQPDIDGALVGGAS 237

                       250
                ....*....|.
gi 13700665 240 LKVEDFVQLLE 250
Cdd:COG0149 238 LDAEDFLAIVR 248
TIM pfam00121
Triosephosphate isomerase; Triosephosphate isomerase (EC:5.3.1.1) (TIM) is the glycolytic ...
 4-252 2.57e-130

Triosephosphate isomerase; Triosephosphate isomerase (EC:5.3.1.1) (TIM) is the glycolytic enzyme that catalyzes the reversible interconversion of glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. TIM plays an important role in several metabolic pathways and is essential for efficient energy production, present in eukaryotes and prokaryotes. TIM is a dimer of identical subunits, each of which is made up of about 250 amino-acid residues. A glutamic acid residue is involved in the catalytic mechanism. The tertiary structure of TIM has eight beta/alpha motifs folded into a barrel structure. The sequence around the active site residue is perfectly conserved in all known TIM's. Deficiencies in TIM are associated with haemolytic anaemia coupled with a progressive, severe neurological disorder.


Pssm-ID: 459680  Cd Length: 244  Bit Score: 367.99  E-value: 2.57e-130
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13700665     4 PIIAGNWKMNKTVQEAKDFVNAL-PTLPDSKEVESVICAPAIQLDALTTAVKEGkaqgLEIGAQNTYFEDNGAFTGETSP 82
Cdd:pfam00121   1 PIIAGNWKMNGTLAEAAELLAELaEALADESGVEVVVAPPFTYLSAVAELLGSN----IKVGAQNVDPEESGAFTGEISA 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13700665    83 VALADLGVKYVVIGHSERRELFHETDEEINKKAHAIFKHGMTPIICVGETDEERESGKANDVVGEQVKKAVAGLSEDQlK 162
Cdd:pfam00121  77 EMLKDLGVSYVIIGHSERRQYFGETDEDVAKKVKAALKAGLTPILCVGETLEEREAGKTEEVVARQLDAALAGLGAEQ-K 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13700665   163 SVVIAYEPIWAIGTGKSSTSEDANEMCAFVRQTIADLsSKEVSEATRIQYGGSVKPNNIKEYMAQTDIDGALVGGASLKV 242
Cdd:pfam00121 156 NLVIAYEPVWAIGTGKTATPEQAQEVHAFIRAVLAEL-YKEVAEGVRILYGGSVKPGNAAELAAQPDIDGALVGGASLKA 234

                         250
                  ....*....|
gi 13700665   243 EDFVQLLEGA 252
Cdd:pfam00121 235 EDFLDIINAA 244
TIM cd00311
Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of ...
 4-250 6.90e-123

Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually homodimeric, but in some organisms tetrameric, is ubiqitous and conserved in function across eukaryotes, bacteria and archaea.


Pssm-ID: 238190  Cd Length: 242  Bit Score: 349.14  E-value: 6.90e-123
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13700665   4 PIIAGNWKMNKTVQEAKDFVNAL-PTLPDSKEVESVICAPAIqldALTTAVKEGKAQGLEIGAQNTYFEDNGAFTGETSP 82
Cdd:cd00311   1 PLVAGNWKMNGTLAEALELAKALnAVLKDESGVEVVVAPPFT---YLAAVAEALEGSKIKVGAQNVSPEDSGAFTGEISA 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13700665  83 VALADLGVKYVVIGHSERRELFHETDEEINKKAHAIFKHGMTPIICVGETDEERESGKANDVVGEQVKKAVAGLseDQLK 162
Cdd:cd00311  78 EMLKDAGAKYVIIGHSERRQYFGETDEDVAKKVKAALEAGLTPILCVGETLEEREAGKTEEVVAAQLAAVLAGV--EDLA 155

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13700665 163 SVVIAYEPIWAIGTGKSSTSEDANEMCAFVRQTIADLSSkEVSEATRIQYGGSVKPNNIKEYMAQTDIDGALVGGASLKV 242
Cdd:cd00311 156 PVVIAYEPVWAIGTGKTASPEQAQEVHAFIRKLLAELYG-EVAEKVRILYGGSVNPENAAELLAQPDIDGVLVGGASLKA 234


                ....*...
gi 13700665 243 EDFVQLLE 250
Cdd:cd00311 235 ESFLDIIK 242
tim TIGR00419
triosephosphate isomerase; Triosephosphate isomerase (tim/TPIA) is the glycolytic enzyme that ...
 5-243 3.05e-37

triosephosphate isomerase; Triosephosphate isomerase (tim/TPIA) is the glycolytic enzyme that catalyzes the reversible interconversion of glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. The active site of the enzyme is located between residues 240-258 of the model ([AV]-Y-E-P-[LIVM]-W-[SA]-I-G-T-[GK]) with E being the active site residue. There is a slight deviation from this sequence within the archeal members of this family. [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 129513 [Multi-domain]  Cd Length: 205  Bit Score: 129.92  E-value: 3.05e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13700665     5 IIAGNWKM-NKTVQEAKDFVNAL-PTLPDSKEVESVICAPAIQLDALTTAVKegkaqgLEIGAQNTYFEDNGAFTGETSP 82
Cdd:TIGR00419   1 LVIGNWKTyNESRGMRALEVAKIaEEVASEAGVAVAVAPPFVDLPMIKREVE------IPVYAQHVDAVLSGAHTGEISA 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13700665    83 VALADLGVKYVVIGHSERRELFHETDEEINKkahaIFKHGMTPIICVgetdeeresgkanDVVGEQvkKAVAGLSEDqlk 162
Cdd:TIGR00419  75 EMLKDIGAKGTLINHSERRMKLADIEKKIAR----LKELGLTSVVCT-------------NNVLTT--AAAAALEPD--- 132

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13700665   163 svVIAYEPIWAIGTGKSSTSEDANEMCAFVRqtiadlSSKEVSEATRIQYGGSVKPNNIKEYMAQTDIDGALVGGASLKV 242
Cdd:TIGR00419 133 --VVAVEPPELIGTGIPVSPAQPEVVHGSVR------AVKEVNESVRVLCGAGISTGEDAELAAQLGAEGVLLASGSLKA 204


                  .
gi 13700665   243 E 243
Cdd:TIGR00419 205 D 205
 
Name Accession Description Interval E-value
tpiA PRK00042
triosephosphate isomerase; Provisional
 2-253 8.04e-148

triosephosphate isomerase; Provisional


Pssm-ID: 234589  Cd Length: 250  Bit Score: 412.59  E-value: 8.04e-148
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13700665    2 RTPIIAGNWKMNKTVQEAKDFVNAL-PTLPDSKEVESVICAPAIQLDALTTAVKegkAQGLEIGAQNTYFEDNGAFTGET 80
Cdd:PRK00042   1 RKPIIAGNWKMNKTLAEAKALVEELkAALPDADGVEVAVAPPFTALASVKEALK---GSNIKLGAQNVHPEDSGAFTGEI 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13700665   81 SPVALADLGVKYVVIGHSERRELFHETDEEINKKAHAIFKHGMTPIICVGETDEERESGKANDVVGEQVKKAVAGLSEDQ 160
Cdd:PRK00042  78 SAEMLKDLGVKYVIIGHSERRQYFGETDELVNKKVKAALKAGLTPILCVGETLEEREAGKTEEVVARQLEAALAGLSAEQ 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13700665  161 LKSVVIAYEPIWAIGTGKSSTSEDANEMCAFVRQTIADLSSkEVSEATRIQYGGSVKPNNIKEYMAQTDIDGALVGGASL 240
Cdd:PRK00042 158 FANLVIAYEPVWAIGTGKTATPEQAQEVHAFIRAVLAELYG-EVAEKVRILYGGSVKPDNAAELMAQPDIDGALVGGASL 236

                        250
                 ....*....|...
gi 13700665  241 KVEDFVQLLEGAK 253
Cdd:PRK00042 237 KAEDFLAIVKAAA 249
TpiA COG0149
Triosephosphate isomerase [Carbohydrate transport and metabolism]; Triosephosphate isomerase ...
 1-250 1.86e-147

Triosephosphate isomerase [Carbohydrate transport and metabolism]; Triosephosphate isomerase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 439919 [Multi-domain]  Cd Length: 249  Bit Score: 411.76  E-value: 1.86e-147
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13700665   1 MRTPIIAGNWKMNKTVQEAKDFVNAL-PTLPDSKEVESVICAPAIQLDALTTAVKEGkaqGLEIGAQNTYFEDNGAFTGE 79
Cdd:COG0149   1 MRKPLIAGNWKMNGTLAEAKALLAALaAALADLADVEVVVCPPFTYLAAVAEALAGS---PIALGAQNVHWEDSGAYTGE 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13700665  80 TSPVALADLGVKYVVIGHSERRELFHETDEEINKKAHAIFKHGMTPIICVGETDEERESGKANDVVGEQVKKAVAGLSED 159
Cdd:COG0149  78 ISAAMLKDLGCRYVIVGHSERRQYFGETDELVNKKVKAALAAGLTPILCVGETLEEREAGKTEEVVARQLKAALAGLSAE 157

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13700665 160 QLKSVVIAYEPIWAIGTGKSSTSEDANEMCAFVRQTIADLSSKEVSEATRIQYGGSVKPNNIKEYMAQTDIDGALVGGAS 239
Cdd:COG0149 158 QAANVVIAYEPVWAIGTGKTATPEQAQEVHAFIRALLAELYGAEVAEAVRILYGGSVKPGNAAELFAQPDIDGALVGGAS 237

                       250
                ....*....|.
gi 13700665 240 LKVEDFVQLLE 250
Cdd:COG0149 238 LDAEDFLAIVR 248
TIM pfam00121
Triosephosphate isomerase; Triosephosphate isomerase (EC:5.3.1.1) (TIM) is the glycolytic ...
 4-252 2.57e-130

Triosephosphate isomerase; Triosephosphate isomerase (EC:5.3.1.1) (TIM) is the glycolytic enzyme that catalyzes the reversible interconversion of glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. TIM plays an important role in several metabolic pathways and is essential for efficient energy production, present in eukaryotes and prokaryotes. TIM is a dimer of identical subunits, each of which is made up of about 250 amino-acid residues. A glutamic acid residue is involved in the catalytic mechanism. The tertiary structure of TIM has eight beta/alpha motifs folded into a barrel structure. The sequence around the active site residue is perfectly conserved in all known TIM's. Deficiencies in TIM are associated with haemolytic anaemia coupled with a progressive, severe neurological disorder.


Pssm-ID: 459680  Cd Length: 244  Bit Score: 367.99  E-value: 2.57e-130
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13700665     4 PIIAGNWKMNKTVQEAKDFVNAL-PTLPDSKEVESVICAPAIQLDALTTAVKEGkaqgLEIGAQNTYFEDNGAFTGETSP 82
Cdd:pfam00121   1 PIIAGNWKMNGTLAEAAELLAELaEALADESGVEVVVAPPFTYLSAVAELLGSN----IKVGAQNVDPEESGAFTGEISA 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13700665    83 VALADLGVKYVVIGHSERRELFHETDEEINKKAHAIFKHGMTPIICVGETDEERESGKANDVVGEQVKKAVAGLSEDQlK 162
Cdd:pfam00121  77 EMLKDLGVSYVIIGHSERRQYFGETDEDVAKKVKAALKAGLTPILCVGETLEEREAGKTEEVVARQLDAALAGLGAEQ-K 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13700665   163 SVVIAYEPIWAIGTGKSSTSEDANEMCAFVRQTIADLsSKEVSEATRIQYGGSVKPNNIKEYMAQTDIDGALVGGASLKV 242
Cdd:pfam00121 156 NLVIAYEPVWAIGTGKTATPEQAQEVHAFIRAVLAEL-YKEVAEGVRILYGGSVKPGNAAELAAQPDIDGALVGGASLKA 234

                         250
                  ....*....|
gi 13700665   243 EDFVQLLEGA 252
Cdd:pfam00121 235 EDFLDIINAA 244
TIM cd00311
Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of ...
 4-250 6.90e-123

Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually homodimeric, but in some organisms tetrameric, is ubiqitous and conserved in function across eukaryotes, bacteria and archaea.


Pssm-ID: 238190  Cd Length: 242  Bit Score: 349.14  E-value: 6.90e-123
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13700665   4 PIIAGNWKMNKTVQEAKDFVNAL-PTLPDSKEVESVICAPAIqldALTTAVKEGKAQGLEIGAQNTYFEDNGAFTGETSP 82
Cdd:cd00311   1 PLVAGNWKMNGTLAEALELAKALnAVLKDESGVEVVVAPPFT---YLAAVAEALEGSKIKVGAQNVSPEDSGAFTGEISA 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13700665  83 VALADLGVKYVVIGHSERRELFHETDEEINKKAHAIFKHGMTPIICVGETDEERESGKANDVVGEQVKKAVAGLseDQLK 162
Cdd:cd00311  78 EMLKDAGAKYVIIGHSERRQYFGETDEDVAKKVKAALEAGLTPILCVGETLEEREAGKTEEVVAAQLAAVLAGV--EDLA 155

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13700665 163 SVVIAYEPIWAIGTGKSSTSEDANEMCAFVRQTIADLSSkEVSEATRIQYGGSVKPNNIKEYMAQTDIDGALVGGASLKV 242
Cdd:cd00311 156 PVVIAYEPVWAIGTGKTASPEQAQEVHAFIRKLLAELYG-EVAEKVRILYGGSVNPENAAELLAQPDIDGVLVGGASLKA 234


                ....*...
gi 13700665 243 EDFVQLLE 250
Cdd:cd00311 235 ESFLDIIK 242
PRK13962 PRK13962
bifunctional phosphoglycerate kinase/triosephosphate isomerase; Provisional
 1-245 2.93e-113

bifunctional phosphoglycerate kinase/triosephosphate isomerase; Provisional


Pssm-ID: 237572 [Multi-domain]  Cd Length: 645  Bit Score: 338.62  E-value: 2.93e-113
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13700665    1 MRTPIIAGNWKMNKTVQEAKDFVNALPTLPDSKEVESVICAPAIQLDALTTAVKEgkaQGLEIGAQNTYFEDNGAFTGET 80
Cdd:PRK13962 396 PRKPIIAGNWKMNKTPAEAKEFVNELKKYVKDAQAEVVVCPPFTALPSVKEAVDG---SNIKLGAQNVFYEEKGAYTGEI 472

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13700665   81 SPVALADLGVKYVVIGHSERRELFHETDEEINKKAHAIFKHGMTPIICVGETDEERESGKANDVVGEQVKKAVAGLSEDQ 160
Cdd:PRK13962 473 SGPMLAEIGVEYVIIGHSERRQYFGETDELVNKKVLAALKAGLTPILCVGETLDERESGITFDVVRLQLKAALNGLSAEQ 552

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13700665  161 LKSVVIAYEPIWAIGTGKSSTSEDANEMCAFVRQTIADLSSKEVSEATRIQYGGSVKPNNIKEYMAQTDIDGALVGGASL 240
Cdd:PRK13962 553 VKKVVIAYEPVWAIGTGKVATPEQAQEVHAFIRKLVAELYGEEAARKVRILYGGSVKSENAAGLFNQPDIDGGLVGGASL 632


                 ....*
gi 13700665  241 KVEDF 245
Cdd:PRK13962 633 KAQEF 637
PTZ00333 PTZ00333
triosephosphate isomerase; Provisional
 1-253 5.43e-94

triosephosphate isomerase; Provisional


Pssm-ID: 240365  Cd Length: 255  Bit Score: 276.41  E-value: 5.43e-94
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13700665    1 MRTPIIAGNWKMNKTVQEAKDFVNALPTLPDSKEVESVICAP-AIQLDALTTAVKEGKAQgleIGAQNTYFEDNGAFTGE 79
Cdd:PTZ00333   3 KRKPFVGGNWKCNGTKASIKELIDSFNKLKFDPNNVDVVVAPpSLHIPLVQEKLKNKNFK---ISSQNVSLTGSGAFTGE 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13700665   80 TSPVALADLGVKYVVIGHSERRELFHETDEEINKKAHAIFKHGMTPIICVGETDEERESGKANDVVGEQVKKAVAGLSED 159
Cdd:PTZ00333  80 ISAEMLKDLGINWTILGHSERRQYFGETNEIVAQKVKNALENGLKVILCIGETLEEREAGQTSDVLSKQLEAIVKKVSDE 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13700665  160 QLKSVVIAYEPIWAIGTGKSSTSEDANEMCAFVRQTIADLSSKEVSEATRIQYGGSVKPNNIKEYMAQTDIDGALVGGAS 239
Cdd:PTZ00333 160 AWDNIVIAYEPVWAIGTGKVATPEQAQEVHAFIRKWLAEKVGADVAEATRIIYGGSVNEKNCKELIKQPDIDGFLVGGAS 239

                        250
                 ....*....|....
gi 13700665  240 LKvEDFVQLLEGAK 253
Cdd:PTZ00333 240 LK-PDFVDIIKSAE 252
PLN02561 PLN02561
triosephosphate isomerase
 2-252 1.07e-63

triosephosphate isomerase


Pssm-ID: 178175  Cd Length: 253  Bit Score: 199.66  E-value: 1.07e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13700665    2 RTPIIAGNWKMNKTVQEAKDFVNAL--PTLPDSKEVESVICAPAIQLdaltTAVKEGKAQGLEIGAQNTYFEDNGAFTGE 79
Cdd:PLN02561   3 RKFFVGGNWKCNGTVEEVKKIVTTLneAEVPSEDVVEVVVSPPFVFL----PLVKSLLRPDFQVAAQNCWVKKGGAFTGE 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13700665   80 TSPVALADLGVKYVVIGHSERRELFHETDEEINKKAHAIFKHGMTPIICVGETDEERESGKANDVVGEQVKKAVAGLSEd 159
Cdd:PLN02561  79 ISAEMLVNLGIPWVILGHSERRALLGESNEFVGDKVAYALSQGLKVIACVGETLEQRESGSTMDVVAAQTKAIADKVSD- 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13700665  160 qLKSVVIAYEPIWAIGTGKSSTSEDANEMCAFVRQTIADLSSKEVSEATRIQYGGSVKPNNIKEYMAQTDIDGALVGGAS 239
Cdd:PLN02561 158 -WANVVLAYEPVWAIGTGKVATPAQAQEVHDELRKWLHKNVSPEVAATTRIIYGGSVTGANCKELAAQPDVDGFLVGGAS 236

                        250
                 ....*....|...
gi 13700665  240 LKVEdFVQLLEGA 252
Cdd:PLN02561 237 LKPE-FIDIIKSA 248
PRK14565 PRK14565
triosephosphate isomerase; Provisional
 5-252 1.00e-59

triosephosphate isomerase; Provisional


Pssm-ID: 237758  Cd Length: 237  Bit Score: 188.81  E-value: 1.00e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13700665    5 IIAGNWKMNKTVQEAKDFVNALPTLPDSKE--VESVICAPAIQLDALTtavkeGKAQGLEIGAQNTYFEDNGAFTGETSP 82
Cdd:PRK14565   4 LIVANWKMNGDFSLFSSFLKELSNKLANNEitLKLVICPPFTAMSSFV-----ECNPNIKLGAQNCFYGSSGGYTGEISA 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13700665   83 VALADLGVKYVVIGHSERRELFHETDEEINKKAHAIFKHGMTPIICVGETDEERESGKANDVVGEQVKKAVAGLSEdqlk 162
Cdd:PRK14565  79 KMLKECGCSYVILGHSERRSTFHETDSDIRLKAESAIESGLIPIICVGETLEDRENGMTKDVLLEQCSNCLPKHGE---- 154

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13700665  163 sVVIAYEPIWAIGTGKSSTsedaNEMCAFVRQTIADLSSKevseaTRIQYGGSVKPNNIKEYMAQTDIDGALVGGASLKV 242
Cdd:PRK14565 155 -FIIAYEPVWAIGGSTIPS----NDAIAEAFEIIRSYDSK-----SHIIYGGSVNQENIRDLKSINQLSGVLVGSASLDV 224

                        250
                 ....*....|
gi 13700665  243 EDFVQLLEGA 252
Cdd:PRK14565 225 DSFCKIIQQV 234
PRK15492 PRK15492
triosephosphate isomerase; Provisional
 9-251 1.84e-55

triosephosphate isomerase; Provisional


Pssm-ID: 185389  Cd Length: 260  Bit Score: 178.65  E-value: 1.84e-55
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13700665    9 NWKMNKTVQEAKDFVNALP----TLPDSKEVE-SVICAPAIQLDALTTAVKEGKAQGLEIGAQNTYFEDNGAFTGETSPV 83
Cdd:PRK15492   9 NLKMYKGIADATDFLAKLSeladDIPADKDIElFVIPSFTAIQDAIAATLAIPHDHPIIIGAQNMNPNDNGQFTGDISPL 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13700665   84 ALADLGVKYVVIGHSERRELFHETDEEINKKAHAIFKHGMTPIICVGETDEERESGKANDVVGEQVKKAVAGLSEDQLKS 163
Cdd:PRK15492  89 MLKEIGTQLVMIGHSERRHKFGETDQEENAKVLAALKHDFTTLLCVGETLEQKNYGISDEILRTQLKIGLHGINPDQLAK 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13700665  164 VVIAYEPIWAIGT-GKSSTSEDANEMCAFVRQTIADLSSKEvSEATRIQYGGSVKPNNIKEYMAQTDIDGALVGGASLKV 242
Cdd:PRK15492 169 LRIAYEPVWAIGEaGIPASADYADEKHAVIKQCLIELFGDA-GDDIPVFYGGSVNAENANELFGQPHIDGLFIGRSAWDA 247


                 ....*....
gi 13700665  243 EDFVQLLEG 251
Cdd:PRK15492 248 DKFFAIIEG 256
PRK14905 PRK14905
triosephosphate isomerase/PTS system glucose/sucrose-specific transporter subunit IIB; ...
 9-252 7.50e-52

triosephosphate isomerase/PTS system glucose/sucrose-specific transporter subunit IIB; Provisional


Pssm-ID: 184898 [Multi-domain]  Cd Length: 355  Bit Score: 172.14  E-value: 7.50e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13700665    9 NWKMNKTVQEAKDFVNAL----PTLPDSKEVESVICAPAIQL-DALTTAVKEGKAQGLEIGAQNTYFEDNGAFTGETSPV 83
Cdd:PRK14905  10 NLKMYKGNAETVDYLSELlafaEKFKSDYDIELFVIPSYIALkDAVEAAASETGHPKIKIGAQNMNAKDKGQFTGEISPL 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13700665   84 ALADLGVKYVVIGHSERRELFHETDEEINKKAHAIFKHGMTPIICVGETDEERESGKANDVVGEQVKKAVAGLSEDQLKS 163
Cdd:PRK14905  90 MLKELGIELVMIGHSERRHVLKETDQEENEKVLAALKHGFITLLCIGETLEQKNYNISDEVLRTQLKIGLHGVSAEQLPH 169

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13700665  164 VVIAYEPIWAIGTGK-SSTSEDANEMCAFVRQTIADLSSKEvSEATRIQYGGSVKPNNIKEYMAQTDIDGALVGGASLKV 242
Cdd:PRK14905 170 LFIAYEPVWAIGEGGiPASAEYADEKHAIIKQCLFELFAEE-SKKIPVLYGGSVNLENANELIMKPHIDGLFIGRSAWDA 248

                        250
                 ....*....|
gi 13700665  243 EDFVQLLEGA 252
Cdd:PRK14905 249 QCFHALIADA 258
PLN02429 PLN02429
triosephosphate isomerase
 7-249 1.02e-46

triosephosphate isomerase


Pssm-ID: 166070  Cd Length: 315  Bit Score: 158.03  E-value: 1.02e-46
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13700665    7 AGNWKMNKTVQEAKDFVNALPTLPDSKEVESVICAPAIQLDAlttaVKEGKAQGLEIGAQNTYFEDNGAFTGETSPVALA 86
Cdd:PLN02429  69 GGNWKCNGTKDSIAKLISDLNSATLEADVDVVVSPPFVYIDQ----VKSSLTDRIDISGQNSWVGKGGAFTGEISVEQLK 144

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13700665   87 DLGVKYVVIGHSERRELFHETDEEINKKAHAIFKHGMTPIICVGETDEERESGKANDVVGEQVKKAVAGLSedQLKSVVI 166
Cdd:PLN02429 145 DLGCKWVILGHSERRHVIGEKDEFIGKKAAYALSEGLGVIACIGEKLEEREAGKTFDVCFAQLKAFADAVP--SWDNIVV 222

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13700665  167 AYEPIWAIGTGKSSTSEDANEMCAFVRQTIADLSSKEVSEATRIQYGGSVKPNNIKEYMAQTDIDGALVGGASLKVEDFV 246
Cdd:PLN02429 223 AYEPVWAIGTGKVASPQQAQEVHVAVRGWLKKNVSEEVASKTRIIYGGSVNGGNSAELAKEEDIDGFLVGGASLKGPEFA 302


                 ...
gi 13700665  247 QLL 249
Cdd:PLN02429 303 TIV 305
tim TIGR00419
triosephosphate isomerase; Triosephosphate isomerase (tim/TPIA) is the glycolytic enzyme that ...
 5-243 3.05e-37

triosephosphate isomerase; Triosephosphate isomerase (tim/TPIA) is the glycolytic enzyme that catalyzes the reversible interconversion of glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. The active site of the enzyme is located between residues 240-258 of the model ([AV]-Y-E-P-[LIVM]-W-[SA]-I-G-T-[GK]) with E being the active site residue. There is a slight deviation from this sequence within the archeal members of this family. [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 129513 [Multi-domain]  Cd Length: 205  Bit Score: 129.92  E-value: 3.05e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13700665     5 IIAGNWKM-NKTVQEAKDFVNAL-PTLPDSKEVESVICAPAIQLDALTTAVKegkaqgLEIGAQNTYFEDNGAFTGETSP 82
Cdd:TIGR00419   1 LVIGNWKTyNESRGMRALEVAKIaEEVASEAGVAVAVAPPFVDLPMIKREVE------IPVYAQHVDAVLSGAHTGEISA 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13700665    83 VALADLGVKYVVIGHSERRELFHETDEEINKkahaIFKHGMTPIICVgetdeeresgkanDVVGEQvkKAVAGLSEDqlk 162
Cdd:TIGR00419  75 EMLKDIGAKGTLINHSERRMKLADIEKKIAR----LKELGLTSVVCT-------------NNVLTT--AAAAALEPD--- 132

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13700665   163 svVIAYEPIWAIGTGKSSTSEDANEMCAFVRqtiadlSSKEVSEATRIQYGGSVKPNNIKEYMAQTDIDGALVGGASLKV 242
Cdd:TIGR00419 133 --VVAVEPPELIGTGIPVSPAQPEVVHGSVR------AVKEVNESVRVLCGAGISTGEDAELAAQLGAEGVLLASGSLKA 204


                  .
gi 13700665   243 E 243
Cdd:TIGR00419 205 D 205
PRK04302 PRK04302
triosephosphate isomerase; Provisional
 1-179 1.32e-10

triosephosphate isomerase; Provisional


Pssm-ID: 235274  Cd Length: 223  Bit Score: 59.50  E-value: 1.32e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13700665    1 MRTPIIAGNWKMNKTV--QEAKDFVNALPTLPDSKEVESVICAPAIQLDALTTAVkegkaqGLEIGAQNTYFEDNGAFTG 78
Cdd:PRK04302   1 MKYPIILVNFKTYPEAtgKDALEIAKAAEKVSKETGVRIAVAPQALDIRRVAEEV------DIPVYAQHVDPVEPGSHTG 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 13700665   79 ETSPVALADLGVKYVVIGHSERRELFhetdEEINKKAHAIFKHGMTPIICVgetdeeresgkaNDVvgeQVKKAVAGLSE 158
Cdd:PRK04302  75 HILPEAVKDAGAVGTLINHSERRLTL----ADIEAVVERAKKLGLESVVCV------------NNP---ETSAAAAALGP 135

                        170       180
                 ....*....|....*....|.
gi 13700665  159 DQlksvvIAYEPIWAIGTGKS 179
Cdd:PRK04302 136 DY-----VAVEPPELIGTGIP 151
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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