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Conserved domains on  [gi|16552346|dbj|BAB71293|]
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unnamed protein product [Homo sapiens]

Protein Classification

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List of domain hits

 Name Accession Description Interval E-value
FA58C cd00057
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached ...
 54-176 2.68e-34

Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.


:

Pssm-ID: 238014 [Multi-domain]  Cd Length: 143  Bit Score: 127.85  E-value: 2.68e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16552346  54 HGPGFSRLNRrdgAGGWTPLVSNKYQWLQIDLGERMEVTAVATQG--GYGSSDWVTSYLLMFSDGGRNWKQYRREESIWG 131
Cdd:cd00057  24 WEASRARLNS---DNAWTPAVNDPPQWLQVDLGKTRRVTGIQTQGrkGGGSSEWVTSYKVQYSLDGETWTTYKDKGEEKV 100

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 16552346 132 FPGNTNADSVVHYRLQPPFEARFLRFLPLAWNprGRIGMRIEVYG 176
Cdd:cd00057 101 FTGNSDGSTPVTNDFPPPIVARYIRILPTTWN--GNISLRLELYG 143
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 212-341 6.71e-26

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


:

Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 103.27  E-value: 6.71e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16552346   212 FKAMQSNGILLHREGQHGNHITLELIKGKLVFFLNSGNAKlpstiaPVTLTLGSLLDDQHWHSVLIELLDTQVNFTVDKH 291
Cdd:pfam02210   1 FRTRQPNGLLLYAGGGGSDFLALELVNGRLVLRYDLGSGP------ESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQ 74

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 16552346   292 THHFQAK-GDSSYLDLNFEISFGGIPTPGRSRAFR-RKSFHGCLENLYYNGV 341
Cdd:pfam02210  75 TVVSSLPpGESLLLNLNGPLYLGGLPPLLLLPALPvRAGFVGCIRDVRVNGE 126
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 398-522 3.38e-24

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


:

Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 98.26  E-value: 3.38e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16552346   398 FRTWNRAGHLLFGElRRGSGSFVLFLKDGKLKLSLFQPGQSPRNVTAGAGLNDGQWHSVSFSAKWSHMNVVVDDDTAVQ- 476
Cdd:pfam02210   1 FRTRQPNGLLLYAG-GGGSDFLALELVNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVSs 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 16552346   477 --PLVAVLIDSGDTYYFGGcLDNSSGSGCKSPLGGFQGCLRLITIGDK 522
Cdd:pfam02210  80 lpPGESLLLNLNGPLYLGG-LPPLLLLPALPVRAGFVGCIRDVRVNGE 126
GGGWT_bact super family cl49103
fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, ...
 591-632 1.18e-07

fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, describes a conserved domain found in eukaryotic proteins such as fibrinogen beta and gamma chains, fincolin, and angiopoietin. This model describes a small homology domain, about 46 amino acids long, found in the PF00147 homology region of those proteins but also as a much shorter homology domain in bacterial proteins that may lack homology to those proteins, or to each other, outside this region. The signature motif, at the C-terminus of this domain, is YCDxTTDGGGWxLV.


The actual alignment was detected with superfamily member NF040941:

Pssm-ID: 468872 [Multi-domain]  Cd Length: 46  Bit Score: 48.71  E-value: 1.18e-07
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 16552346  591 SCEA--HKHRGNPSGLYYIDADGSGPLGPFLVYCNMTDA--AWTVV 632
Cdd:NF040941   1 SCWEilQAGPSAPSGVYWIDPDGMGGLAPFQVYCDMTTDggGWTLV 46
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 551-582 1.89e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


:

Pssm-ID: 394967  Cd Length: 31  Bit Score: 39.29  E-value: 1.89e-04
                          10        20        30
                  ....*....|....*....|....*....|..
gi 16552346   551 CLPSYCEHGGECSQSWDTFSCDCLgTGYTGET 582
Cdd:pfam00008   1 CAPNPCSNGGTCVDTPGGYTCICP-EGYTGKR 31
 
Name Accession Description Interval E-value
FA58C cd00057
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached ...
 54-176 2.68e-34

Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.


Pssm-ID: 238014 [Multi-domain]  Cd Length: 143  Bit Score: 127.85  E-value: 2.68e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16552346  54 HGPGFSRLNRrdgAGGWTPLVSNKYQWLQIDLGERMEVTAVATQG--GYGSSDWVTSYLLMFSDGGRNWKQYRREESIWG 131
Cdd:cd00057  24 WEASRARLNS---DNAWTPAVNDPPQWLQVDLGKTRRVTGIQTQGrkGGGSSEWVTSYKVQYSLDGETWTTYKDKGEEKV 100

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 16552346 132 FPGNTNADSVVHYRLQPPFEARFLRFLPLAWNprGRIGMRIEVYG 176
Cdd:cd00057 101 FTGNSDGSTPVTNDFPPPIVARYIRILPTTWN--GNISLRLELYG 143
F5_F8_type_C pfam00754
F5/8 type C domain; This domain is also known as the discoidin (DS) domain family.
 54-174 8.13e-29

F5/8 type C domain; This domain is also known as the discoidin (DS) domain family.


Pssm-ID: 459925 [Multi-domain]  Cd Length: 127  Bit Score: 111.39  E-value: 8.13e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16552346    54 HGPGFSRLNRRDG--AGGWTPLVSNKYQWLQIDLGERMEVTAVATQGGY-GSSDWVTSYLLMFSDGGRNWKQYRREEsiw 130
Cdd:pfam00754   8 YSGEGPAAAALDGdpNTAWSAWSGDDPQWIQVDLGKPKKITGVVTQGRQdGSNGYVTSYKIEYSLDGENWTTVKDEK--- 84

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 16552346   131 gFPGNTNADSVVHYRLQPPFEARFLRFLPLAWNPRGRIGMRIEV 174
Cdd:pfam00754  85 -IPGNNDNNTPVTNTFDPPIKARYVRIVPTSWNGGNGIALRAEL 127
FA58C smart00231
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached ...
 55-177 1.15e-27

Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.


Pssm-ID: 214572  Cd Length: 139  Bit Score: 108.75  E-value: 1.15e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16552346     55 GPGFSRLNRrDGAGGWTPLVSNKYQWLQIDLGERMEVTAVATQGGYGSSDWVTSYlLMFSDGGRNWKQYRREESIwGFPG 134
Cdd:smart00231  22 AAKIARLNG-GSDGGWCPAKNDLPPWIQVDLGRLRTVTGVITGRRHGNGDWVTYK-LEYSDDGVNWTTYKDGNSK-VFPG 98

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|...
gi 16552346    135 NTNADSVVHYRLQPPFEARFLRFLPLAWNprGRIGMRIEVYGC 177
Cdd:smart00231  99 NSDAGTVVLNDFPPPIVARYVRILPTGWN--GNIILRVELLGC 139
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 212-341 6.71e-26

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 103.27  E-value: 6.71e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16552346   212 FKAMQSNGILLHREGQHGNHITLELIKGKLVFFLNSGNAKlpstiaPVTLTLGSLLDDQHWHSVLIELLDTQVNFTVDKH 291
Cdd:pfam02210   1 FRTRQPNGLLLYAGGGGSDFLALELVNGRLVLRYDLGSGP------ESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQ 74

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 16552346   292 THHFQAK-GDSSYLDLNFEISFGGIPTPGRSRAFR-RKSFHGCLENLYYNGV 341
Cdd:pfam02210  75 TVVSSLPpGESLLLNLNGPLYLGGLPPLLLLPALPvRAGFVGCIRDVRVNGE 126
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 183-339 1.21e-24

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 100.57  E-value: 1.21e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16552346 183 VVYFDGQSAllYRLDKKPLKPIRDVISLKFKAMQSNGILLHREGQ-HGNHITLELIKGKLVFFLNSGNAklpstiaPVTL 261
Cdd:cd00110   1 GVSFSGSSY--VRLPTLPAPRTRLSISFSFRTTSPNGLLLYAGSQnGGDFLALELEDGRLVLRYDLGSG-------SLVL 71

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16552346 262 TLGSLLDDQHWHSVLIELLDTQVNFTVDKHTH-HFQAKGDSSYLDLNFEISFGGIPTPGRSRAFR-RKSFHGCLENLYYN 339
Cdd:cd00110  72 SSKTPLNDGQWHSVSVERNGRSVTLSVDGERVvESGSPGGSALLNLDGPLYLGGLPEDLKSPGLPvSPGFVGCIRDLKVN 151
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 398-522 3.38e-24

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 98.26  E-value: 3.38e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16552346   398 FRTWNRAGHLLFGElRRGSGSFVLFLKDGKLKLSLFQPGQSPRNVTAGAGLNDGQWHSVSFSAKWSHMNVVVDDDTAVQ- 476
Cdd:pfam02210   1 FRTRQPNGLLLYAG-GGGSDFLALELVNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVSs 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 16552346   477 --PLVAVLIDSGDTYYFGGcLDNSSGSGCKSPLGGFQGCLRLITIGDK 522
Cdd:pfam02210  80 lpPGESLLLNLNGPLYLGG-LPPLLLLPALPVRAGFVGCIRDVRVNGE 126
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 371-519 1.38e-23

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 97.49  E-value: 1.38e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16552346 371 PVTFlSSRSYLALPGNSGE-DKVSVTFQFRTWNRAGHLLFGELRRGSGSFVLFLKDGKLKLSlFQPGQSPRNVTAGAGLN 449
Cdd:cd00110   1 GVSF-SGSSYVRLPTLPAPrTRLSISFSFRTTSPNGLLLYAGSQNGGDFLALELEDGRLVLR-YDLGSGSLVLSSKTPLN 78

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 16552346 450 DGQWHSVSFSAKWSHMNVVVDDDTAVQ---PLVAVLIDSGDTYYFGGcLDNSSGSGCKSPLGGFQGCLRLITI 519
Cdd:cd00110  79 DGQWHSVSVERNGRSVTLSVDGERVVEsgsPGGSALLNLDGPLYLGG-LPEDLKSPGLPVSPGFVGCIRDLKV 150
LamG smart00282
Laminin G domain;
208-341 7.98e-22

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 91.63  E-value: 7.98e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16552346    208 ISLKFKAMQSNGILLH-REGQHGNHITLELIKGKLVFFLNSGNaklpstiAPVTLTLGSL-LDDQHWHSVLIELLDTQVN 285
Cdd:smart00282   2 ISFSFRTTSPNGLLLYaGSKGGGDYLALELRDGRLVLRYDLGS-------GPARLTSDPTpLNDGQWHRVAVERNGRSVT 74

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 16552346    286 FTVDKHTH-HFQAKGDSSYLDLNFEISFGGIPTPGRSRAFR-RKSFHGCLENLYYNGV 341
Cdd:smart00282  75 LSVDGGNRvSGESPGGLTILNLDGPLYLGGLPEDLKLPPLPvTPGFRGCIRNLKVNGK 132
LamG smart00282
Laminin G domain;
393-522 1.76e-19

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 85.08  E-value: 1.76e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16552346    393 SVTFQFRTWNRAGHLLFGELRRGSGSFVLFLKDGKLKLSlFQPGQSPRNVTAGAG-LNDGQWHSVSFSAKWSHMNVVVDD 471
Cdd:smart00282   1 SISFSFRTTSPNGLLLYAGSKGGGDYLALELRDGRLVLR-YDLGSGPARLTSDPTpLNDGQWHRVAVERNGRSVTLSVDG 79

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 16552346    472 DTAVQ---PLVAVLIDSGDTYYFGGCLDNSSGSGcKSPLGGFQGCLRLITIGDK 522
Cdd:smart00282  80 GNRVSgesPGGLTILNLDGPLYLGGLPEDLKLPP-LPVTPGFRGCIRNLKVNGK 132
GGGWT_bact NF040941
fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, ...
 591-632 1.18e-07

fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, describes a conserved domain found in eukaryotic proteins such as fibrinogen beta and gamma chains, fincolin, and angiopoietin. This model describes a small homology domain, about 46 amino acids long, found in the PF00147 homology region of those proteins but also as a much shorter homology domain in bacterial proteins that may lack homology to those proteins, or to each other, outside this region. The signature motif, at the C-terminus of this domain, is YCDxTTDGGGWxLV.


Pssm-ID: 468872 [Multi-domain]  Cd Length: 46  Bit Score: 48.71  E-value: 1.18e-07
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 16552346  591 SCEA--HKHRGNPSGLYYIDADGSGPLGPFLVYCNMTDA--AWTVV 632
Cdd:NF040941   1 SCWEilQAGPSAPSGVYWIDPDGMGGLAPFQVYCDMTTDggGWTLV 46
FReD cd00087
Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is ...
 590-634 1.51e-04

Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular arrangement called the disulfide knot. The C termini of fibrinogen chains end in globular domains, which are not completely equivalent. C terminal globular domains of the gamma chains (C-gamma) dimerize and bind to the GPR motif of the N-terminal domain of the alpha chain, while the GHR motif of N-terminal domain of the beta chain binds to the C terminal globular domains of another beta chain (C-beta), which leads to lattice formation.


Pssm-ID: 238040 [Multi-domain]  Cd Length: 215  Bit Score: 43.77  E-value: 1.51e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*...
gi 16552346 590 QSC-EAHKHRGNPSGLYYIDADGSGPlgPFLVYCNMTDA--AWTVVQH 634
Cdd:cd00087   4 RDCsEVLQRGGRTSGVYTIQPPGSNE--PFQVYCDMDTDggGWTVIQR 49
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 551-582 1.89e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 39.29  E-value: 1.89e-04
                          10        20        30
                  ....*....|....*....|....*....|..
gi 16552346   551 CLPSYCEHGGECSQSWDTFSCDCLgTGYTGET 582
Cdd:pfam00008   1 CAPNPCSNGGTCVDTPGGYTCICP-EGYTGKR 31
FBG smart00186
Fibrinogen-related domains (FReDs); Domain present at the C-termini of fibrinogen beta and ...
 593-634 1.17e-03

Fibrinogen-related domains (FReDs); Domain present at the C-termini of fibrinogen beta and gamma chains, and a variety of fibrinogen-related proteins, including tenascin and Drosophila scabrous.


Pssm-ID: 214548 [Multi-domain]  Cd Length: 212  Bit Score: 41.11  E-value: 1.17e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 16552346    593 EAHKHRGNPSGLYYIDADGSGPlgPFLVYCNM-TDA-AWTVVQH 634
Cdd:smart00186   7 DVLQNGGKTSGLYTIYPDGSSR--PLKVYCDMeTDGgGWTVIQR 48
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 549-583 1.36e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.85  E-value: 1.36e-03
                        10        20        30
                ....*....|....*....|....*....|....*.
gi 16552346 549 DRCL-PSYCEHGGECSQSWDTFSCDCLgTGYTGETC 583
Cdd:cd00054   3 DECAsGNPCQNGGTCVNTVGSYRCSCP-PGYTGRNC 37
 
Name Accession Description Interval E-value
FA58C cd00057
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached ...
 54-176 2.68e-34

Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.


Pssm-ID: 238014 [Multi-domain]  Cd Length: 143  Bit Score: 127.85  E-value: 2.68e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16552346  54 HGPGFSRLNRrdgAGGWTPLVSNKYQWLQIDLGERMEVTAVATQG--GYGSSDWVTSYLLMFSDGGRNWKQYRREESIWG 131
Cdd:cd00057  24 WEASRARLNS---DNAWTPAVNDPPQWLQVDLGKTRRVTGIQTQGrkGGGSSEWVTSYKVQYSLDGETWTTYKDKGEEKV 100

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 16552346 132 FPGNTNADSVVHYRLQPPFEARFLRFLPLAWNprGRIGMRIEVYG 176
Cdd:cd00057 101 FTGNSDGSTPVTNDFPPPIVARYIRILPTTWN--GNISLRLELYG 143
F5_F8_type_C pfam00754
F5/8 type C domain; This domain is also known as the discoidin (DS) domain family.
 54-174 8.13e-29

F5/8 type C domain; This domain is also known as the discoidin (DS) domain family.


Pssm-ID: 459925 [Multi-domain]  Cd Length: 127  Bit Score: 111.39  E-value: 8.13e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16552346    54 HGPGFSRLNRRDG--AGGWTPLVSNKYQWLQIDLGERMEVTAVATQGGY-GSSDWVTSYLLMFSDGGRNWKQYRREEsiw 130
Cdd:pfam00754   8 YSGEGPAAAALDGdpNTAWSAWSGDDPQWIQVDLGKPKKITGVVTQGRQdGSNGYVTSYKIEYSLDGENWTTVKDEK--- 84

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 16552346   131 gFPGNTNADSVVHYRLQPPFEARFLRFLPLAWNPRGRIGMRIEV 174
Cdd:pfam00754  85 -IPGNNDNNTPVTNTFDPPIKARYVRIVPTSWNGGNGIALRAEL 127
FA58C smart00231
Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached ...
 55-177 1.15e-27

Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes.


Pssm-ID: 214572  Cd Length: 139  Bit Score: 108.75  E-value: 1.15e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16552346     55 GPGFSRLNRrDGAGGWTPLVSNKYQWLQIDLGERMEVTAVATQGGYGSSDWVTSYlLMFSDGGRNWKQYRREESIwGFPG 134
Cdd:smart00231  22 AAKIARLNG-GSDGGWCPAKNDLPPWIQVDLGRLRTVTGVITGRRHGNGDWVTYK-LEYSDDGVNWTTYKDGNSK-VFPG 98

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|...
gi 16552346    135 NTNADSVVHYRLQPPFEARFLRFLPLAWNprGRIGMRIEVYGC 177
Cdd:smart00231  99 NSDAGTVVLNDFPPPIVARYVRILPTGWN--GNIILRVELLGC 139
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 212-341 6.71e-26

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 103.27  E-value: 6.71e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16552346   212 FKAMQSNGILLHREGQHGNHITLELIKGKLVFFLNSGNAKlpstiaPVTLTLGSLLDDQHWHSVLIELLDTQVNFTVDKH 291
Cdd:pfam02210   1 FRTRQPNGLLLYAGGGGSDFLALELVNGRLVLRYDLGSGP------ESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQ 74

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 16552346   292 THHFQAK-GDSSYLDLNFEISFGGIPTPGRSRAFR-RKSFHGCLENLYYNGV 341
Cdd:pfam02210  75 TVVSSLPpGESLLLNLNGPLYLGGLPPLLLLPALPvRAGFVGCIRDVRVNGE 126
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 183-339 1.21e-24

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 100.57  E-value: 1.21e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16552346 183 VVYFDGQSAllYRLDKKPLKPIRDVISLKFKAMQSNGILLHREGQ-HGNHITLELIKGKLVFFLNSGNAklpstiaPVTL 261
Cdd:cd00110   1 GVSFSGSSY--VRLPTLPAPRTRLSISFSFRTTSPNGLLLYAGSQnGGDFLALELEDGRLVLRYDLGSG-------SLVL 71

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16552346 262 TLGSLLDDQHWHSVLIELLDTQVNFTVDKHTH-HFQAKGDSSYLDLNFEISFGGIPTPGRSRAFR-RKSFHGCLENLYYN 339
Cdd:cd00110  72 SSKTPLNDGQWHSVSVERNGRSVTLSVDGERVvESGSPGGSALLNLDGPLYLGGLPEDLKSPGLPvSPGFVGCIRDLKVN 151
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 398-522 3.38e-24

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 98.26  E-value: 3.38e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16552346   398 FRTWNRAGHLLFGElRRGSGSFVLFLKDGKLKLSLFQPGQSPRNVTAGAGLNDGQWHSVSFSAKWSHMNVVVDDDTAVQ- 476
Cdd:pfam02210   1 FRTRQPNGLLLYAG-GGGSDFLALELVNGRLVLRYDLGSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVSs 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 16552346   477 --PLVAVLIDSGDTYYFGGcLDNSSGSGCKSPLGGFQGCLRLITIGDK 522
Cdd:pfam02210  80 lpPGESLLLNLNGPLYLGG-LPPLLLLPALPVRAGFVGCIRDVRVNGE 126
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 371-519 1.38e-23

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 97.49  E-value: 1.38e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16552346 371 PVTFlSSRSYLALPGNSGE-DKVSVTFQFRTWNRAGHLLFGELRRGSGSFVLFLKDGKLKLSlFQPGQSPRNVTAGAGLN 449
Cdd:cd00110   1 GVSF-SGSSYVRLPTLPAPrTRLSISFSFRTTSPNGLLLYAGSQNGGDFLALELEDGRLVLR-YDLGSGSLVLSSKTPLN 78

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 16552346 450 DGQWHSVSFSAKWSHMNVVVDDDTAVQ---PLVAVLIDSGDTYYFGGcLDNSSGSGCKSPLGGFQGCLRLITI 519
Cdd:cd00110  79 DGQWHSVSVERNGRSVTLSVDGERVVEsgsPGGSALLNLDGPLYLGG-LPEDLKSPGLPVSPGFVGCIRDLKV 150
LamG smart00282
Laminin G domain;
208-341 7.98e-22

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 91.63  E-value: 7.98e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16552346    208 ISLKFKAMQSNGILLH-REGQHGNHITLELIKGKLVFFLNSGNaklpstiAPVTLTLGSL-LDDQHWHSVLIELLDTQVN 285
Cdd:smart00282   2 ISFSFRTTSPNGLLLYaGSKGGGDYLALELRDGRLVLRYDLGS-------GPARLTSDPTpLNDGQWHRVAVERNGRSVT 74

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 16552346    286 FTVDKHTH-HFQAKGDSSYLDLNFEISFGGIPTPGRSRAFR-RKSFHGCLENLYYNGV 341
Cdd:smart00282  75 LSVDGGNRvSGESPGGLTILNLDGPLYLGGLPEDLKLPPLPvTPGFRGCIRNLKVNGK 132
LamG smart00282
Laminin G domain;
393-522 1.76e-19

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 85.08  E-value: 1.76e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16552346    393 SVTFQFRTWNRAGHLLFGELRRGSGSFVLFLKDGKLKLSlFQPGQSPRNVTAGAG-LNDGQWHSVSFSAKWSHMNVVVDD 471
Cdd:smart00282   1 SISFSFRTTSPNGLLLYAGSKGGGDYLALELRDGRLVLR-YDLGSGPARLTSDPTpLNDGQWHRVAVERNGRSVTLSVDG 79

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 16552346    472 DTAVQ---PLVAVLIDSGDTYYFGGCLDNSSGSGcKSPLGGFQGCLRLITIGDK 522
Cdd:smart00282  80 GNRVSgesPGGLTILNLDGPLYLGGLPEDLKLPP-LPVTPGFRGCIRNLKVNGK 132
Laminin_G_1 pfam00054
Laminin G domain;
398-525 5.63e-14

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 69.27  E-value: 5.63e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16552346   398 FRTWNRAGHLLFGELRRGSGSFVLFLKDGKLKLSlFQPGQSPRNVTAGAGLNDGQWHSVSFSAKWSHMNVVVDDDTAV-- 475
Cdd:pfam00054   1 FRTTEPSGLLLYNGTQTERDFLALELRDGRLEVS-YDLGSGAAVVRSGDKLNDGKWHSVELERNGRSGTLSVDGEARPtg 79

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 16552346   476 -QPL-VAVLIDSGDTYYFGGCLDNSSGSGCKSPLGGFQGCLRLITIGDKAVD 525
Cdd:pfam00054  80 eSPLgATTDLDVDGPLYVGGLPSLGVKKRRLAISPSFDGCIRDVIVNGKPLD 131
Laminin_G_1 pfam00054
Laminin G domain;
212-341 1.06e-12

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 65.80  E-value: 1.06e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16552346   212 FKAMQSNGILLHREGQ-HGNHITLELIKGKLVFFLNSGNAklpstiaPVTLTLGSLLDDQHWHSVLIELLDTQVNFTVDK 290
Cdd:pfam00054   1 FRTTEPSGLLLYNGTQtERDFLALELRDGRLEVSYDLGSG-------AAVVRSGDKLNDGKWHSVELERNGRSGTLSVDG 73

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 16552346   291 -HTHHF-QAKGDSSYLDLNFEISFGGIPTPG--RSRAFRRKSFHGCLENLYYNGV 341
Cdd:pfam00054  74 eARPTGeSPLGATTDLDVDGPLYVGGLPSLGvkKRRLAISPSFDGCIRDVIVNGK 128
GGGWT_bact NF040941
fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, ...
 591-632 1.18e-07

fibrinogen-like bacterial YCDxxxxGGGW domain; Pfam model PF00147, about 220 amino acids long, describes a conserved domain found in eukaryotic proteins such as fibrinogen beta and gamma chains, fincolin, and angiopoietin. This model describes a small homology domain, about 46 amino acids long, found in the PF00147 homology region of those proteins but also as a much shorter homology domain in bacterial proteins that may lack homology to those proteins, or to each other, outside this region. The signature motif, at the C-terminus of this domain, is YCDxTTDGGGWxLV.


Pssm-ID: 468872 [Multi-domain]  Cd Length: 46  Bit Score: 48.71  E-value: 1.18e-07
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 16552346  591 SCEA--HKHRGNPSGLYYIDADGSGPLGPFLVYCNMTDA--AWTVV 632
Cdd:NF040941   1 SCWEilQAGPSAPSGVYWIDPDGMGGLAPFQVYCDMTTDggGWTLV 46
FReD cd00087
Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is ...
 590-634 1.51e-04

Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular arrangement called the disulfide knot. The C termini of fibrinogen chains end in globular domains, which are not completely equivalent. C terminal globular domains of the gamma chains (C-gamma) dimerize and bind to the GPR motif of the N-terminal domain of the alpha chain, while the GHR motif of N-terminal domain of the beta chain binds to the C terminal globular domains of another beta chain (C-beta), which leads to lattice formation.


Pssm-ID: 238040 [Multi-domain]  Cd Length: 215  Bit Score: 43.77  E-value: 1.51e-04
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*...
gi 16552346 590 QSC-EAHKHRGNPSGLYYIDADGSGPlgPFLVYCNMTDA--AWTVVQH 634
Cdd:cd00087   4 RDCsEVLQRGGRTSGVYTIQPPGSNE--PFQVYCDMDTDggGWTVIQR 49
EGF pfam00008
EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very ...
 551-582 1.89e-04

EGF-like domain; There is no clear separation between noise and signal. pfam00053 is very similar, but has 8 instead of 6 conserved cysteines. Includes some cytokine receptors. The EGF domain misses the N-terminus regions of the Ca2+ binding EGF domains (this is the main reason of discrepancy between swiss-prot domain start/end and Pfam). The family is hard to model due to many similar but different sub-types of EGF domains. Pfam certainly misses a number of EGF domains.


Pssm-ID: 394967  Cd Length: 31  Bit Score: 39.29  E-value: 1.89e-04
                          10        20        30
                  ....*....|....*....|....*....|..
gi 16552346   551 CLPSYCEHGGECSQSWDTFSCDCLgTGYTGET 582
Cdd:pfam00008   1 CAPNPCSNGGTCVDTPGGYTCICP-EGYTGKR 31
FBG smart00186
Fibrinogen-related domains (FReDs); Domain present at the C-termini of fibrinogen beta and ...
 593-634 1.17e-03

Fibrinogen-related domains (FReDs); Domain present at the C-termini of fibrinogen beta and gamma chains, and a variety of fibrinogen-related proteins, including tenascin and Drosophila scabrous.


Pssm-ID: 214548 [Multi-domain]  Cd Length: 212  Bit Score: 41.11  E-value: 1.17e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 16552346    593 EAHKHRGNPSGLYYIDADGSGPlgPFLVYCNM-TDA-AWTVVQH 634
Cdd:smart00186   7 DVLQNGGKTSGLYTIYPDGSSR--PLKVYCDMeTDGgGWTVIQR 48
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 549-583 1.36e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 36.85  E-value: 1.36e-03
                        10        20        30
                ....*....|....*....|....*....|....*.
gi 16552346 549 DRCL-PSYCEHGGECSQSWDTFSCDCLgTGYTGETC 583
Cdd:cd00054   3 DECAsGNPCQNGGTCVNTVGSYRCSCP-PGYTGRNC 37
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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