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Conserved domains on  [gi|21751852|dbj|BAC04051|]
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unnamed protein product [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 1000017)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 269-369 5.87e-14

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 71.60  E-value: 5.87e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21751852 269 HDSAVTSLQILQDGQFLVSSDMTGTIKLWDLRATKCVTQYEGHvnNSAYLPVHVNEEEGVVAAVGQDCYTRIWSLRHGHL 348
Cdd:cd00200  92 HTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGH--TDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKC 169

                        90       100
                ....*....|....*....|.
gi 21751852 349 LTTIpspyPASENDIPSVAFS 369
Cdd:cd00200 170 VATL----TGHTGEVNSVAFS 186
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 269-369 5.87e-14

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 71.60  E-value: 5.87e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21751852 269 HDSAVTSLQILQDGQFLVSSDMTGTIKLWDLRATKCVTQYEGHvnNSAYLPVHVNEEEGVVAAVGQDCYTRIWSLRHGHL 348
Cdd:cd00200  92 HTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGH--TDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKC 169

                        90       100
                ....*....|....*....|.
gi 21751852 349 LTTIpspyPASENDIPSVAFS 369
Cdd:cd00200 170 VATL----TGHTGEVNSVAFS 186
WD40 COG2319
WD40 repeat [General function prediction only];
269-369 2.27e-13

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 71.10  E-value: 2.27e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21751852 269 HDSAVTSLQILQDGQFLVSSDMTGTIKLWDLRATKCVTQYEGH---VNNSAYLPvhvneeEG-VVAAVGQDCYTRIWSLR 344
Cdd:COG2319 161 HSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHtgaVRSVAFSP------DGkLLASGSADGTVRLWDLA 234

                        90       100
                ....*....|....*....|....*
gi 21751852 345 HGHLLTTIPSPypasENDIPSVAFS 369
Cdd:COG2319 235 TGKLLRTLTGH----SGSVRSVAFS 255
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 269-298 4.38e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.37  E-value: 4.38e-05
                           10        20        30
                   ....*....|....*....|....*....|
gi 21751852    269 HDSAVTSLQILQDGQFLVSSDMTGTIKLWD 298
Cdd:smart00320  11 HTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
269-298 6.27e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.02  E-value: 6.27e-05
                          10        20        30
                  ....*....|....*....|....*....|
gi 21751852   269 HDSAVTSLQILQDGQFLVSSDMTGTIKLWD 298
Cdd:pfam00400  10 HTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 269-369 5.87e-14

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 71.60  E-value: 5.87e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21751852 269 HDSAVTSLQILQDGQFLVSSDMTGTIKLWDLRATKCVTQYEGHvnNSAYLPVHVNEEEGVVAAVGQDCYTRIWSLRHGHL 348
Cdd:cd00200  92 HTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGH--TDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKC 169

                        90       100
                ....*....|....*....|.
gi 21751852 349 LTTIpspyPASENDIPSVAFS 369
Cdd:cd00200 170 VATL----TGHTGEVNSVAFS 186
WD40 COG2319
WD40 repeat [General function prediction only];
269-369 2.27e-13

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 71.10  E-value: 2.27e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21751852 269 HDSAVTSLQILQDGQFLVSSDMTGTIKLWDLRATKCVTQYEGH---VNNSAYLPvhvneeEG-VVAAVGQDCYTRIWSLR 344
Cdd:COG2319 161 HSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHtgaVRSVAFSP------DGkLLASGSADGTVRLWDLA 234

                        90       100
                ....*....|....*....|....*
gi 21751852 345 HGHLLTTIPSPypasENDIPSVAFS 369
Cdd:COG2319 235 TGKLLRTLTGH----SGSVRSVAFS 255
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 263-370 6.09e-13

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 68.52  E-value: 6.09e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21751852 263 KAICLSHDSAVTSLQILQDGQFLVSSDMTGTIKLWDLRATKCVTQYEGH---VNNSAYLPvhvneEEGVVAAVGQDCYTR 339
Cdd:cd00200 128 LTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHtgeVNSVAFSP-----DGEKLLSSSSDGTIK 202

                        90       100       110
                ....*....|....*....|....*....|.
gi 21751852 340 IWSLRHGHLLTTipspYPASENDIPSVAFSS 370
Cdd:cd00200 203 LWDLSTGKCLGT----LRGHENGVNSVAFSP 229
WD40 COG2319
WD40 repeat [General function prediction only];
269-369 3.11e-12

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 67.63  E-value: 3.11e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21751852 269 HDSAVTSLQILQDGQFLVSSDMTGTIKLWDLRATKCVTQYEGH---VNNSAYLPvhvneeEG-VVAAVGQDCYTRIWSLR 344
Cdd:COG2319 245 HSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHsggVNSVAFSP------DGkLLASGSDDGTVRLWDLA 318

                        90       100
                ....*....|....*....|....*
gi 21751852 345 HGHLLTTIpspyPASENDIPSVAFS 369
Cdd:COG2319 319 TGKLLRTL----TGHTGAVRSVAFS 339
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 164-342 1.94e-11

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 64.28  E-value: 1.94e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21751852 164 FIGSFPGMRRPGMLCSFQiPDAW---SCAWSLSIHAYhSFSTGLSQQVLltnvvTGHQqsfgtsSDVLAQQFAIMTPLLF 240
Cdd:cd00200 127 CLTTLRGHTDWVNSVAFS-PDGTfvaSSSQDGTIKLW-DLRTGKCVATL-----TGHT------GEVNSVAFSPDGEKLL 193

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21751852 241 NGCRSGEIFGIDLRCGNqgsgWKAICLSHDSAVTSLQILQDGQFLVSSDMTGTIKLWDLRATKCVTQYEGHvNNSAYLpV 320
Cdd:cd00200 194 SSSSDGTIKLWDLSTGK----CLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGH-TNSVTS-L 267

                       170       180
                ....*....|....*....|..
gi 21751852 321 HVNEEEGVVAAVGQDCYTRIWS 342
Cdd:cd00200 268 AWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
269-369 2.16e-11

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 64.93  E-value: 2.16e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21751852 269 HDSAVTSLQILQDGQFLVSSDMTGTIKLWDLRATKCVTQYEGH---VNNSAYLPvhvneeEG-VVAAVGQDCYTRIWSLR 344
Cdd:COG2319 119 HTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHsgaVTSVAFSP------DGkLLASGSDDGTVRLWDLA 192

                        90       100
                ....*....|....*....|....*
gi 21751852 345 HGHLLTTIpspyPASENDIPSVAFS 369
Cdd:COG2319 193 TGKLLRTL----TGHTGAVRSVAFS 213
WD40 COG2319
WD40 repeat [General function prediction only];
269-369 2.49e-11

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 64.55  E-value: 2.49e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21751852 269 HDSAVTSLQILQDGQFLVSSDMTGTIKLWDLRATKCVTQYEGHVNnsAYLPVHVNEEEGVVAAVGQDCYTRIWSLRHGHL 348
Cdd:COG2319 287 HSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTG--AVRSVAFSPDGKTLASGSDDGTVRLWDLATGEL 364

                        90       100
                ....*....|....*....|.
gi 21751852 349 LTTIpspyPASENDIPSVAFS 369
Cdd:COG2319 365 LRTL----TGHTGAVTSVAFS 381
WD40 COG2319
WD40 repeat [General function prediction only];
258-369 5.36e-09

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 57.61  E-value: 5.36e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21751852 258 QGSGWKAICLSHDSAVTSLQILQDGQFLVSSDMTGTIKLWDLRATKCVTQYEGH---VNNSAYLPvhvneeEG-VVAAVG 333
Cdd:COG2319  66 AAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHtgaVRSVAFSP------DGkTLASGS 139

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 21751852 334 QDCYTRIWSLRHGHLLTTIPSPypasENDIPSVAFS 369
Cdd:COG2319 140 ADGTVRLWDLATGKLLRTLTGH----SGAVTSVAFS 171
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 268-369 1.16e-08

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 55.80  E-value: 1.16e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21751852 268 SHDSAVTSLQILQDGQFLVSSDMTGTIKLWDLRATKCVTQYEGH---VNNSAYLPVHvneeeGVVAAVGQDCYTRIWSLR 344
Cdd:cd00200   7 GHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHtgpVRDVAASADG-----TYLASGSSDKTIRLWDLE 81

                        90       100
                ....*....|....*....|....*
gi 21751852 345 HGHLLTTipspYPASENDIPSVAFS 369
Cdd:cd00200  82 TGECVRT----LTGHTSYVSSVAFS 102
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 269-298 4.38e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.37  E-value: 4.38e-05
                           10        20        30
                   ....*....|....*....|....*....|
gi 21751852    269 HDSAVTSLQILQDGQFLVSSDMTGTIKLWD 298
Cdd:smart00320  11 HTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
269-298 6.27e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.02  E-value: 6.27e-05
                          10        20        30
                  ....*....|....*....|....*....|
gi 21751852   269 HDSAVTSLQILQDGQFLVSSDMTGTIKLWD 298
Cdd:pfam00400  10 HTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 COG2319
WD40 repeat [General function prediction only];
269-300 1.46e-04

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 43.75  E-value: 1.46e-04
                        10        20        30
                ....*....|....*....|....*....|..
gi 21751852 269 HDSAVTSLQILQDGQFLVSSDMTGTIKLWDLR 300
Cdd:COG2319 371 HTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
267-369 7.37e-04

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 41.44  E-value: 7.37e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21751852 267 LSHDSAVTSLQILQDGQFLVSSDMTGTIKLWDLRATKCVTQYEGHVnnSAYLPVHVNEEEGVVAAVGQDCYTRIWSLRHG 346
Cdd:COG2319  33 LGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHT--AAVLSVAFSPDGRLLASASADGTVRLWDLATG 110

                        90       100
                ....*....|....*....|...
gi 21751852 347 HLLTTIpspyPASENDIPSVAFS 369
Cdd:COG2319 111 LLLRTL----TGHTGAVRSVAFS 129
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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