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Conserved domains on  [gi|21752363|dbj|BAC04180|]
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unnamed protein product, partial [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DUF3827 super family cl28786
Domain of unknown function (DUF3827); This family contains the Swiss:Q9HCM3 protein which has ...
 53-151 5.03e-04

Domain of unknown function (DUF3827); This family contains the Swiss:Q9HCM3 protein which has been found to be fused fused to BRAF gene in many cases of pilocytic astrocytomas. The fusion is due mainly to a tandem duplication of 2 Mb at 7q34. Although nothing is known about the function of Swiss:Q9HCM3 protein, the BRAF protein is a well characterized oncoprotein. It is a serine/threonine protein kinase which is implicated in MAP/ERK signalling, a critical pathway for the regulation of cell division, differentiation and secretion.


The actual alignment was detected with superfamily member pfam12877:

Pssm-ID: 463737  Cd Length: 677  Bit Score: 43.24  E-value: 5.03e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21752363    53 VARATPGR-GEVESDKSVAASGAGKAARrqvegRRGQVSPSDS----SDPRG-LEAAKEAELPLQTERHTKEKRKVTEA- 125
Cdd:pfam12877 345 VKDATPSEnGEVPTPKSKTSSKTSRGER-----RRGRISPSDGdsvgSDESSkRESGEESPRPAATPSDGKQHRKTNRPg 419

                          90       100       110
                  ....*....|....*....|....*....|...
gi 21752363   126 ----SSDDPQPG---LDLVRKESLTSSESFQTV 151
Cdd:pfam12877 420 npmnGVSEQLSSasiFEHVDRMSRGSADAFRRS 452
 
Name Accession Description Interval E-value
DUF3827 pfam12877
Domain of unknown function (DUF3827); This family contains the Swiss:Q9HCM3 protein which has ...
 53-151 5.03e-04

Domain of unknown function (DUF3827); This family contains the Swiss:Q9HCM3 protein which has been found to be fused fused to BRAF gene in many cases of pilocytic astrocytomas. The fusion is due mainly to a tandem duplication of 2 Mb at 7q34. Although nothing is known about the function of Swiss:Q9HCM3 protein, the BRAF protein is a well characterized oncoprotein. It is a serine/threonine protein kinase which is implicated in MAP/ERK signalling, a critical pathway for the regulation of cell division, differentiation and secretion.


Pssm-ID: 463737  Cd Length: 677  Bit Score: 43.24  E-value: 5.03e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21752363    53 VARATPGR-GEVESDKSVAASGAGKAARrqvegRRGQVSPSDS----SDPRG-LEAAKEAELPLQTERHTKEKRKVTEA- 125
Cdd:pfam12877 345 VKDATPSEnGEVPTPKSKTSSKTSRGER-----RRGRISPSDGdsvgSDESSkRESGEESPRPAATPSDGKQHRKTNRPg 419

                          90       100       110
                  ....*....|....*....|....*....|...
gi 21752363   126 ----SSDDPQPG---LDLVRKESLTSSESFQTV 151
Cdd:pfam12877 420 npmnGVSEQLSSasiFEHVDRMSRGSADAFRRS 452
 
Name Accession Description Interval E-value
DUF3827 pfam12877
Domain of unknown function (DUF3827); This family contains the Swiss:Q9HCM3 protein which has ...
 53-151 5.03e-04

Domain of unknown function (DUF3827); This family contains the Swiss:Q9HCM3 protein which has been found to be fused fused to BRAF gene in many cases of pilocytic astrocytomas. The fusion is due mainly to a tandem duplication of 2 Mb at 7q34. Although nothing is known about the function of Swiss:Q9HCM3 protein, the BRAF protein is a well characterized oncoprotein. It is a serine/threonine protein kinase which is implicated in MAP/ERK signalling, a critical pathway for the regulation of cell division, differentiation and secretion.


Pssm-ID: 463737  Cd Length: 677  Bit Score: 43.24  E-value: 5.03e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21752363    53 VARATPGR-GEVESDKSVAASGAGKAARrqvegRRGQVSPSDS----SDPRG-LEAAKEAELPLQTERHTKEKRKVTEA- 125
Cdd:pfam12877 345 VKDATPSEnGEVPTPKSKTSSKTSRGER-----RRGRISPSDGdsvgSDESSkRESGEESPRPAATPSDGKQHRKTNRPg 419

                          90       100       110
                  ....*....|....*....|....*....|...
gi 21752363   126 ----SSDDPQPG---LDLVRKESLTSSESFQTV 151
Cdd:pfam12877 420 npmnGVSEQLSSasiFEHVDRMSRGSADAFRRS 452
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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