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Conserved domains on  [gi|21755011|dbj|BAC04610|]
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unnamed protein product [Homo sapiens]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11473525)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation; similar to Homo sapiens zinc finger protein 35

CATH:  3.30.160.60
Gene Ontology:  GO:0003677|GO:0008270|GO:0003700
PubMed:  11179890|12665246|11361095|10940247|22803940|30718982
SCOP:  4003583

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
276-689 1.71e-13

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 73.58  E-value: 1.71e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21755011 276 KPYECIECGKTFSKTSHLRAHQRIHTGEKPYEC--VECEKTFSHKTHLSVHQRVHTGEKPYECNDCGKSftYNSALRAHQ 353
Cdd:COG5048  32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPL--SNSKASSSS 109

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21755011 354 RIHTGEKPYECSDCEK---TFAHNSALRAHHRIHTGEKPYECNECGRSFAH-ISVLKAHQRIHTRekpyecNECGRSFTY 429
Cdd:COG5048 110 LSSSSSNSNDNNLLSShslPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNtPQSNSLHPPLPAN------SLSKDPSSN 183

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21755011 430 NSALRAHQRIHTGRKPYECSDCEKTfAHNSALKIHQRIHTGEKPYKCNECEKTFAHNSALRAHQNIHTGEKLYECSECGK 509
Cdd:COG5048 184 LSLLISSNVSTSIPSSSENSPLSSS-YSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPR 262

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21755011 510 TFFQKTRLSTHRRIHTGE-------KPYECSKCGKTFSQKSYLSGHER--IHTGE--KPYECNV--CGKTFVYKAALIVH 576
Cdd:COG5048 263 SSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRH 342

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21755011 577 QRIHTGEKPYEC--NECGKTFSQRTHLCAHQRIH-----TGEKPYEC--NECGKTFADNSALRAHHRIHTGEKPYECND- 646
Cdd:COG5048 343 ILLHTSISPAKEklLNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKNp 422

                       410       420       430       440
                ....*....|....*....|....*....|....*....|....
gi 21755011 647 -CGKTFSKTSHLRAHLRTHSGEKPYECSECGKTFSEKSYVSAHQ 689
Cdd:COG5048 423 pCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
zf-H2C2_2 pfam13465
Zinc-finger double domain;
769-793 1.01e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 1.01e-03
                          10        20
                  ....*....|....*....|....*
gi 21755011   769 LRVHQRIHTGEKPYECDECGKTFVR 793
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
740-765 2.13e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 2.13e-03
                          10        20
                  ....*....|....*....|....*.
gi 21755011   740 HLSAHQRIHTGEKPYECNECGKAFAQ 765
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 726-748 5.88e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


:

Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.97  E-value: 5.88e-03
                          10        20
                  ....*....|....*....|...
gi 21755011   726 YECNDCGKTFSQKSHLSAHQRIH 748
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
713-737 9.12e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 9.12e-03
                          10        20
                  ....*....|....*....|....*
gi 21755011   713 LRVHQRIHTGEKSYECNDCGKTFSQ 737
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
276-689 1.71e-13

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 73.58  E-value: 1.71e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21755011 276 KPYECIECGKTFSKTSHLRAHQRIHTGEKPYEC--VECEKTFSHKTHLSVHQRVHTGEKPYECNDCGKSftYNSALRAHQ 353
Cdd:COG5048  32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPL--SNSKASSSS 109

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21755011 354 RIHTGEKPYECSDCEK---TFAHNSALRAHHRIHTGEKPYECNECGRSFAH-ISVLKAHQRIHTRekpyecNECGRSFTY 429
Cdd:COG5048 110 LSSSSSNSNDNNLLSShslPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNtPQSNSLHPPLPAN------SLSKDPSSN 183

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21755011 430 NSALRAHQRIHTGRKPYECSDCEKTfAHNSALKIHQRIHTGEKPYKCNECEKTFAHNSALRAHQNIHTGEKLYECSECGK 509
Cdd:COG5048 184 LSLLISSNVSTSIPSSSENSPLSSS-YSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPR 262

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21755011 510 TFFQKTRLSTHRRIHTGE-------KPYECSKCGKTFSQKSYLSGHER--IHTGE--KPYECNV--CGKTFVYKAALIVH 576
Cdd:COG5048 263 SSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRH 342

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21755011 577 QRIHTGEKPYEC--NECGKTFSQRTHLCAHQRIH-----TGEKPYEC--NECGKTFADNSALRAHHRIHTGEKPYECND- 646
Cdd:COG5048 343 ILLHTSISPAKEklLNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKNp 422

                       410       420       430       440
                ....*....|....*....|....*....|....*....|....
gi 21755011 647 -CGKTFSKTSHLRAHLRTHSGEKPYECSECGKTFSEKSYVSAHQ 689
Cdd:COG5048 423 pCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
zf-H2C2_2 pfam13465
Zinc-finger double domain;
769-793 1.01e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 1.01e-03
                          10        20
                  ....*....|....*....|....*
gi 21755011   769 LRVHQRIHTGEKPYECDECGKTFVR 793
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
460-485 1.62e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.62e-03
                          10        20
                  ....*....|....*....|....*.
gi 21755011   460 ALKIHQRIHTGEKPYKCNECEKTFAH 485
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
740-765 2.13e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 2.13e-03
                          10        20
                  ....*....|....*....|....*.
gi 21755011   740 HLSAHQRIHTGEKPYECNECGKAFAQ 765
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 726-748 5.88e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.97  E-value: 5.88e-03
                          10        20
                  ....*....|....*....|...
gi 21755011   726 YECNDCGKTFSQKSHLSAHQRIH 748
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
713-737 9.12e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 9.12e-03
                          10        20
                  ....*....|....*....|....*
gi 21755011   713 LRVHQRIHTGEKSYECNDCGKTFSQ 737
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
276-689 1.71e-13

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 73.58  E-value: 1.71e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21755011 276 KPYECIECGKTFSKTSHLRAHQRIHTGEKPYEC--VECEKTFSHKTHLSVHQRVHTGEKPYECNDCGKSftYNSALRAHQ 353
Cdd:COG5048  32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPL--SNSKASSSS 109

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21755011 354 RIHTGEKPYECSDCEK---TFAHNSALRAHHRIHTGEKPYECNECGRSFAH-ISVLKAHQRIHTRekpyecNECGRSFTY 429
Cdd:COG5048 110 LSSSSSNSNDNNLLSShslPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNtPQSNSLHPPLPAN------SLSKDPSSN 183

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21755011 430 NSALRAHQRIHTGRKPYECSDCEKTfAHNSALKIHQRIHTGEKPYKCNECEKTFAHNSALRAHQNIHTGEKLYECSECGK 509
Cdd:COG5048 184 LSLLISSNVSTSIPSSSENSPLSSS-YSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPR 262

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21755011 510 TFFQKTRLSTHRRIHTGE-------KPYECSKCGKTFSQKSYLSGHER--IHTGE--KPYECNV--CGKTFVYKAALIVH 576
Cdd:COG5048 263 SSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRH 342

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21755011 577 QRIHTGEKPYEC--NECGKTFSQRTHLCAHQRIH-----TGEKPYEC--NECGKTFADNSALRAHHRIHTGEKPYECND- 646
Cdd:COG5048 343 ILLHTSISPAKEklLNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKNp 422

                       410       420       430       440
                ....*....|....*....|....*....|....*....|....
gi 21755011 647 -CGKTFSKTSHLRAHLRTHSGEKPYECSECGKTFSEKSYVSAHQ 689
Cdd:COG5048 423 pCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
388-804 3.26e-13

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 72.81  E-value: 3.26e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21755011 388 KPYECNECGRSFAHISVLKAHQRIHTREKPYECNECGRSFTY--NSALRAHQRIHTGRKPYECSDCEKTfAHNSALKIHQ 465
Cdd:COG5048  32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFsrPLELSRHLRTHHNNPSDLNSKSLPL-SNSKASSSSL 110

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21755011 466 RIHTGEKPYKCNECEKTFAHNSALRAHQNIHTGEKLYECSECGKTFFQKTRLSTHRRIHTGEKPYECskcgKTFSQKSYL 545
Cdd:COG5048 111 SSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPANSLS----KDPSSNLSL 186

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21755011 546 SGHERIHTGEKPYECNVCGKTFVYKAALIVHQRIHTGEKPYECNECGKTFSQRTHLCAHQRIHTGEKPYECNECGKTFAD 625
Cdd:COG5048 187 LISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLP 266

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21755011 626 NSALRAHHRIHTGE-------KPYECNDCGKTFSKTSHLRAHLRT--HSGE--KPYECSE--CGKTFSEKSYVSAHQRVH 692
Cdd:COG5048 267 TASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSRNDALKRHILLH 346

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21755011 693 TGEKPYEC--NVCGKPFAHNSTLRVHQRIH-----TGEKSYEC--NDCGKTFSQKSHLSAHQRIHTGEKPYECN--ECGK 761
Cdd:COG5048 347 TSISPAKEklLNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSK 426

                       410       420       430       440
                ....*....|....*....|....*....|....*....|...
gi 21755011 762 AFAQNSTLRVHQRIHTGEKPYECdeCGKTFVRKAALRVHHTRM 804
Cdd:COG5048 427 SFNRHYNLIPHKKIHTNHAPLLC--SILKSFRRDLDLSNHGKD 467
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
170-604 3.99e-12

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 69.34  E-value: 3.99e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21755011 170 KTYQYEECAKSFCSSSHPIQHPGTYVGFKLYECN--ECGKAFCQNSNLSKHLRIHTKEKPCDNNGCGRSYKSPLIGHQ-- 245
Cdd:COG5048  32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSls 111

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21755011 246 ---KTDAEMELC----GGSEYGKTSHLKGHQRILMGEKPYE-CIECGKTFSKTSHLRAhqrihtgekPYECVECEKTFSH 317
Cdd:COG5048 112 sssSNSNDNNLLsshsLPPSSRDPQLPDLLSISNLRNNPLPgNNSSSVNTPQSNSLHP---------PLPANSLSKDPSS 182

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21755011 318 KTHLSVHQRVHTGEKPYECNDCGKSFTYNSALRAHQRIHTGEKPYECSD----CEKTFAHNSALRAHHRIHTGEKPyECN 393
Cdd:COG5048 183 NLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTnsqlSPKSLLSQSPSSLSSSDSSSSAS-ESP 261

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21755011 394 ECGRSFAHiSVLKAHQRIHTRE-----KPYECNECGRSFTYNSALRAHQR--IHTG--RKPYEC--SDCEKTFAHNSALK 462
Cdd:COG5048 262 RSSLPTAS-SQSSSPNESDSSSekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGesLKPFSCpySLCGKLFSRNDALK 340

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21755011 463 IHQRIHTGEKPYKC--NECEKTFAHNSALRAHQNIHtgeklyecsecgktffqktrlstHRRIHTGEKPYEC--SKCGKT 538
Cdd:COG5048 341 RHILLHTSISPAKEklLNSSSKFSPLLNNEPPQSLQ-----------------------QYKDLKNDKKSETlsNSCIRN 397

                       410       420       430       440       450       460
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 21755011 539 FSQKSYLSGHERIHTGEKPYECN--VCGKTFVYKAALIVHQRIHTGEKPYECNECGKtFSQRTHLCAH 604
Cdd:COG5048 398 FKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS-FRRDLDLSNH 464
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
444-819 2.29e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 67.03  E-value: 2.29e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21755011 444 KPYECSDCEKTFAHNSALKIHQRIHTGEKPYKCN--ECEKTFAHNSALRAHQNIHTGEKLYECSECGKTFFQKTRLSTHR 521
Cdd:COG5048  32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLS 111

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21755011 522 RIHTGE-KPYECSKCGKTFSQKSYLSGHERIHTGEKPYECNVCGKTFV--YKAALIVHQRIHtgekpyecNECGKTFSQR 598
Cdd:COG5048 112 SSSSNSnDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVntPQSNSLHPPLPA--------NSLSKDPSSN 183

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21755011 599 THLCAHQRIHTGEKPYECNECGKTFADNSALRAHHRIHTGEKPYECNDCGKTFSKTSHLRAHLRTHSGEKPYECSECGKT 678
Cdd:COG5048 184 LSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRS 263

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21755011 679 FSEKSYVSAHQRVHTGE-------KPYECNVCGKPFAHNSTLRVHQR--IHTGEKSYEC----NDCGKTFSQKSHLSAHQ 745
Cdd:COG5048 264 SLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGESLKPFscpySLCGKLFSRNDALKRHI 343

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21755011 746 RIHTGEKPYEC--NECGKAFAQNSTLRVHQRIH-----TGEKPYECD--ECGKTFVRKAALRVhHTRMHTREKTLACNGF 816
Cdd:COG5048 344 LLHTSISPAKEklLNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETLsnSCIRNFKRDSNLSL-HIITHLSFRPYNCKNP 422


                ...
gi 21755011 817 GKS 819
Cdd:COG5048 423 PCS 425
zf-H2C2_2 pfam13465
Zinc-finger double domain;
769-793 1.01e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 1.01e-03
                          10        20
                  ....*....|....*....|....*
gi 21755011   769 LRVHQRIHTGEKPYECDECGKTFVR 793
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
460-485 1.62e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.62e-03
                          10        20
                  ....*....|....*....|....*.
gi 21755011   460 ALKIHQRIHTGEKPYKCNECEKTFAH 485
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 302-385 1.80e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.63  E-value: 1.80e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21755011 302 GEKPYEC--VECEKTFSHKTHLSVHqRVHtgekpyecNDCGKSFTYNSALRAHQRIHTGEKPYECSDCEKTFAHNSALRa 379
Cdd:COG5189 346 DGKPYKCpvEGCNKKYKNQNGLKYH-MLH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLK- 415


                ....*.
gi 21755011 380 HHRIHT 385
Cdd:COG5189 416 YHRKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
740-765 2.13e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 2.13e-03
                          10        20
                  ....*....|....*....|....*.
gi 21755011   740 HLSAHQRIHTGEKPYECNECGKAFAQ 765
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
656-680 3.62e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 3.62e-03
                          10        20
                  ....*....|....*....|....*
gi 21755011   656 HLRAHLRTHSGEKPYECSECGKTFS 680
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 638-716 3.79e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.47  E-value: 3.79e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21755011 638 GEKPYECN--DCGKTFSKTSHLRAH-LRTHSGEKPYEcsecgkTFSEKSyvsaHQRVHTGEKPYECNVCGKPFAHNSTLR 714
Cdd:COG5189 346 DGKPYKCPveGCNKKYKNQNGLKYHmLHGHQNQKLHE------NPSPEK----MNIFSAKDKPYRCEVCDKRYKNLNGLK 415


                ..
gi 21755011 715 VH 716
Cdd:COG5189 416 YH 417
zf-H2C2_2 pfam13465
Zinc-finger double domain;
348-373 4.24e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 4.24e-03
                          10        20
                  ....*....|....*....|....*.
gi 21755011   348 ALRAHQRIHTGEKPYECSDCEKTFAH 373
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
320-345 4.41e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 4.41e-03
                          10        20
                  ....*....|....*....|....*.
gi 21755011   320 HLSVHQRVHTGEKPYECNDCGKSFTY 345
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
572-597 4.54e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 4.54e-03
                          10        20
                  ....*....|....*....|....*.
gi 21755011   572 ALIVHQRIHTGEKPYECNECGKTFSQ 597
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 726-748 5.88e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.97  E-value: 5.88e-03
                          10        20
                  ....*....|....*....|...
gi 21755011   726 YECNDCGKTFSQKSHLSAHQRIH 748
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
376-401 6.15e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 6.15e-03
                          10        20
                  ....*....|....*....|....*.
gi 21755011   376 ALRAHHRIHTGEKPYECNECGRSFAH 401
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
516-541 7.72e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 7.72e-03
                          10        20
                  ....*....|....*....|....*.
gi 21755011   516 RLSTHRRIHTGEKPYECSKCGKTFSQ 541
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
713-737 9.12e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 9.12e-03
                          10        20
                  ....*....|....*....|....*
gi 21755011   713 LRVHQRIHTGEKSYECNDCGKTFSQ 737
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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