NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|21756436|dbj|BAC04877|]
View 

unnamed protein product [Homo sapiens]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
GHB_like super family cl21545
Glycoprotein hormone beta chain homologues; This family of cystine-knot hormones includes the ...
 287-363 5.28e-07

Glycoprotein hormone beta chain homologues; This family of cystine-knot hormones includes the beta chains of gonadotropins, thyrotropins, follitropins, choriogonadotropins and more. The members are reproductive hormones that consist of two glycosylated chains (alpha and beta), which form a tightly bound dimer.


The actual alignment was detected with superfamily member smart00041:

Pssm-ID: 473907  Cd Length: 82  Bit Score: 47.01  E-value: 5.28e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 21756436    287 IRKQDCMSqSPINVASCDGKCPSATIYNINIESHlrFCKCCRENGVRNLSVPLYCSgNGTEIMYTLQEPIDCTCQWN 363
Cdd:smart00041   8 ITYNGCTS-VTVKNAFCEGKCGSASSYSIQDVQH--SCSCCQPHKTKTRQVRLRCP-DGSTVKKTVMHIEECGCEPN 80
 
Name Accession Description Interval E-value
CT smart00041
C-terminal cystine knot-like domain (CTCK); The structures of transforming growth factor-beta ...
 287-363 5.28e-07

C-terminal cystine knot-like domain (CTCK); The structures of transforming growth factor-beta (TGFbeta), nerve growth factor (NGF), platelet-derived growth factor (PDGF) and gonadotropin all form 2 highly twisted antiparallel pairs of beta-strands and contain three disulphide bonds. The domain is non-globular and little is conserved among these presumed homologues except for their cysteine residues. CT domains are predicted to form homodimers.


Pssm-ID: 214482  Cd Length: 82  Bit Score: 47.01  E-value: 5.28e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 21756436    287 IRKQDCMSqSPINVASCDGKCPSATIYNINIESHlrFCKCCRENGVRNLSVPLYCSgNGTEIMYTLQEPIDCTCQWN 363
Cdd:smart00041   8 ITYNGCTS-VTVKNAFCEGKCGSASSYSIQDVQH--SCSCCQPHKTKTRQVRLRCP-DGSTVKKTVMHIEECGCEPN 80
 
Name Accession Description Interval E-value
CT smart00041
C-terminal cystine knot-like domain (CTCK); The structures of transforming growth factor-beta ...
 287-363 5.28e-07

C-terminal cystine knot-like domain (CTCK); The structures of transforming growth factor-beta (TGFbeta), nerve growth factor (NGF), platelet-derived growth factor (PDGF) and gonadotropin all form 2 highly twisted antiparallel pairs of beta-strands and contain three disulphide bonds. The domain is non-globular and little is conserved among these presumed homologues except for their cysteine residues. CT domains are predicted to form homodimers.


Pssm-ID: 214482  Cd Length: 82  Bit Score: 47.01  E-value: 5.28e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 21756436    287 IRKQDCMSqSPINVASCDGKCPSATIYNINIESHlrFCKCCRENGVRNLSVPLYCSgNGTEIMYTLQEPIDCTCQWN 363
Cdd:smart00041   8 ITYNGCTS-VTVKNAFCEGKCGSASSYSIQDVQH--SCSCCQPHKTKTRQVRLRCP-DGSTVKKTVMHIEECGCEPN 80
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH