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Conserved domains on  [gi|21756718|dbj|BAC04941|]
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unnamed protein product [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TM6SF1-like super family cl42080
transmembrane 6 superfamily member 1, member 2, and similar proteins; This family includes ...
 7-99 7.53e-34

transmembrane 6 superfamily member 1, member 2, and similar proteins; This family includes transmembrane 6 superfamily members 1 (TM6SF1) and 2 (TM6SF2), and similar proteins. TM6SF1 is a widely expressed lysosomal transmembrane protein that may be suitable as a lysosomal marker. Polymorphism of its paralog, TM6SF2, has been associated with the risk for hepatocellular carcinoma, and a variant of the gene has been found to impact the processing of lipids in the liver and the small intestine, causing non-alcoholic fatty liver disease (NAFLD).


The actual alignment was detected with superfamily member cd21106:

Pssm-ID: 477942  Cd Length: 356  Bit Score: 123.83  E-value: 7.53e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21756718   7 AGKIAALSLSALPVSYALNHVSALSHPLWVALMSALILGLLFVAVYSLSHGEV-SYDPLYAVFAVFAFTSVVDLIIALQE 85
Cdd:cd21106   1 ATGVFLLSLLAIPVSYLLNKLSALLDPVAILIAGVVVLLAVFLLPYLLFRRKRkPKDPLFYVFAVFAFTSVIDLIIALEL 80

                        90
                ....*....|....
gi 21756718  86 DSYVVGFMEFYTKE 99
Cdd:cd21106  81 DGIISGFMEFYLKE 94
 
Name Accession Description Interval E-value
TM6SF1-like cd21106
transmembrane 6 superfamily member 1, member 2, and similar proteins; This family includes ...
 7-99 7.53e-34

transmembrane 6 superfamily member 1, member 2, and similar proteins; This family includes transmembrane 6 superfamily members 1 (TM6SF1) and 2 (TM6SF2), and similar proteins. TM6SF1 is a widely expressed lysosomal transmembrane protein that may be suitable as a lysosomal marker. Polymorphism of its paralog, TM6SF2, has been associated with the risk for hepatocellular carcinoma, and a variant of the gene has been found to impact the processing of lipids in the liver and the small intestine, causing non-alcoholic fatty liver disease (NAFLD).


Pssm-ID: 411047  Cd Length: 356  Bit Score: 123.83  E-value: 7.53e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21756718   7 AGKIAALSLSALPVSYALNHVSALSHPLWVALMSALILGLLFVAVYSLSHGEV-SYDPLYAVFAVFAFTSVVDLIIALQE 85
Cdd:cd21106   1 ATGVFLLSLLAIPVSYLLNKLSALLDPVAILIAGVVVLLAVFLLPYLLFRRKRkPKDPLFYVFAVFAFTSVIDLIIALEL 80

                        90
                ....*....|....
gi 21756718  86 DSYVVGFMEFYTKE 99
Cdd:cd21106  81 DGIISGFMEFYLKE 94
 
Name Accession Description Interval E-value
TM6SF1-like cd21106
transmembrane 6 superfamily member 1, member 2, and similar proteins; This family includes ...
 7-99 7.53e-34

transmembrane 6 superfamily member 1, member 2, and similar proteins; This family includes transmembrane 6 superfamily members 1 (TM6SF1) and 2 (TM6SF2), and similar proteins. TM6SF1 is a widely expressed lysosomal transmembrane protein that may be suitable as a lysosomal marker. Polymorphism of its paralog, TM6SF2, has been associated with the risk for hepatocellular carcinoma, and a variant of the gene has been found to impact the processing of lipids in the liver and the small intestine, causing non-alcoholic fatty liver disease (NAFLD).


Pssm-ID: 411047  Cd Length: 356  Bit Score: 123.83  E-value: 7.53e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21756718   7 AGKIAALSLSALPVSYALNHVSALSHPLWVALMSALILGLLFVAVYSLSHGEV-SYDPLYAVFAVFAFTSVVDLIIALQE 85
Cdd:cd21106   1 ATGVFLLSLLAIPVSYLLNKLSALLDPVAILIAGVVVLLAVFLLPYLLFRRKRkPKDPLFYVFAVFAFTSVIDLIIALEL 80

                        90
                ....*....|....
gi 21756718  86 DSYVVGFMEFYTKE 99
Cdd:cd21106  81 DGIISGFMEFYLKE 94
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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