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Conserved domains on  [gi|21758308|dbj|BAC05284|]
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unnamed protein product [Homo sapiens]

Protein Classification

G protein-coupled receptor family protein( domain architecture ID 705710)

G protein-coupled receptor family protein is a seven-transmembrane G protein-coupled receptor (7TM-GPCR) family protein which typically transmits an extracellular signal into the cell by the conformational rearrangement of the 7TM helices and by the subsequent binding and activation of an intracellular heterotrimeric G protein; GPCR ligands include light-sensitive compounds, odors, pheromones, hormones, and neurotransmitters

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List of domain hits

Name Accession Description Interval E-value
7tm_GPCRs super family cl28897
seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary ...
6-279 5.15e-180

seven-transmembrane G protein-coupled receptor superfamily; This hierarchical evolutionary model represents the seven-transmembrane (7TM) receptors, often referred to as G protein-coupled receptors (GPCRs), which transmit physiological signals from the outside of the cell to the inside via G proteins. GPCRs constitute the largest known superfamily of transmembrane receptors across the three kingdoms of life that respond to a wide variety of extracellular stimuli including peptides, lipids, neurotransmitters, amino acids, hormones, and sensory stimuli such as light, smell and taste. All GPCRs share a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. However, some 7TM receptors, such as the type 1 microbial rhodopsins, do not activate G proteins. Based on sequence similarity, GPCRs can be divided into six major classes: class A (the rhodopsin-like family), class B (the Methuselah-like, adhesion and secretin-like receptor family), class C (the metabotropic glutamate receptor family), class D (the fungal mating pheromone receptors), class E (the cAMP receptor family), and class F (the frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


The actual alignment was detected with superfamily member cd15109:

Pssm-ID: 475119  Cd Length: 274  Bit Score: 497.51  E-value: 5.15e-180
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21758308   6 AVMNYIFLLLCLCGLVGNGLVLWFFGFSIKRNPFSIYFLHLASADVGYLFSKAVFSILNTGGFLGTFADYIRSVCRVLGL 85
Cdd:cd15109   1 AVMNYIFLLLCLCGLVGNGLVLWFFGFSIKRNPFSIYFLHLASADVGYLFSKAVFSILNTGGFLGTFADYIRSVSRILGL 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21758308  86 CMFLTGVSLLPAVSAERCASVIFPAWYWRRRPKRLSAVVCALLWVLSLLVTCLHNYFCVFLGRGAPGAACRHMDIFLGIL 165
Cdd:cd15109  81 CTFLTGVSLLPAISIERCVSVIFPTWYWRRRPKRLSAVVCALLWMLSLLVTCIHNYFCVFLGREAPGAACRHMDIFLGIL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21758308 166 LFLLCCPLMVLPCLALILHVECRARRRQRSAKLNHVILAMVSVFLVSSIYLGIDWFLFWVFQIPAPFPEYVTDLCICINS 245
Cdd:cd15109 161 LFLLFCPLMVLPCLALILHVECRARRRQRSAKLNHVILAMVSVFLVSSIYLGIDWFLFWVFQIPAPFPEYVTDLCICINS 240
                       250       260       270
                ....*....|....*....|....*....|....
gi 21758308 246 SAKPIVYFLAGRDKSQRLWEPLRVVFQRALRDGA 279
Cdd:cd15109 241 SAKPIVYFLAGRDKSQRLWEPLRVVFQRALRDGA 274
 
Name Accession Description Interval E-value
7tmA_MrgprF cd15109
mas-related G protein-coupled receptor subtype F, member of the class A family of ...
6-279 5.15e-180

mas-related G protein-coupled receptor subtype F, member of the class A family of seven-transmembrane G protein-coupled receptors; The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined.


Pssm-ID: 320237  Cd Length: 274  Bit Score: 497.51  E-value: 5.15e-180
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21758308   6 AVMNYIFLLLCLCGLVGNGLVLWFFGFSIKRNPFSIYFLHLASADVGYLFSKAVFSILNTGGFLGTFADYIRSVCRVLGL 85
Cdd:cd15109   1 AVMNYIFLLLCLCGLVGNGLVLWFFGFSIKRNPFSIYFLHLASADVGYLFSKAVFSILNTGGFLGTFADYIRSVSRILGL 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21758308  86 CMFLTGVSLLPAVSAERCASVIFPAWYWRRRPKRLSAVVCALLWVLSLLVTCLHNYFCVFLGRGAPGAACRHMDIFLGIL 165
Cdd:cd15109  81 CTFLTGVSLLPAISIERCVSVIFPTWYWRRRPKRLSAVVCALLWMLSLLVTCIHNYFCVFLGREAPGAACRHMDIFLGIL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21758308 166 LFLLCCPLMVLPCLALILHVECRARRRQRSAKLNHVILAMVSVFLVSSIYLGIDWFLFWVFQIPAPFPEYVTDLCICINS 245
Cdd:cd15109 161 LFLLFCPLMVLPCLALILHVECRARRRQRSAKLNHVILAMVSVFLVSSIYLGIDWFLFWVFQIPAPFPEYVTDLCICINS 240
                       250       260       270
                ....*....|....*....|....*....|....
gi 21758308 246 SAKPIVYFLAGRDKSQRLWEPLRVVFQRALRDGA 279
Cdd:cd15109 241 SAKPIVYFLAGRDKSQRLWEPLRVVFQRALRDGA 274
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
23-142 1.04e-09

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 58.08  E-value: 1.04e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21758308    23 NGLVLWFFGFSIK-RNPFSIYFLHLASADVGY----LFSKAVFSILNTGGFLGTFadyirsVCRVLGLCMFLTGVS---L 94
Cdd:pfam00001   2 NLLVILVILRNKKlRTPTNIFLLNLAVADLLFslltLPFWLVYYLNHGDWPFGSA------LCKIVGALFVVNGYAsilL 75
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 21758308    95 LPAVSAERCASVIFPAWYWRRRPKRLSAVVCALLWVLSLLVTCLHNYF 142
Cdd:pfam00001  76 LTAISIDRYLAIVHPLRYKRRRTPRRAKVLILVIWVLALLLSLPPLLF 123
 
Name Accession Description Interval E-value
7tmA_MrgprF cd15109
mas-related G protein-coupled receptor subtype F, member of the class A family of ...
6-279 5.15e-180

mas-related G protein-coupled receptor subtype F, member of the class A family of seven-transmembrane G protein-coupled receptors; The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined.


Pssm-ID: 320237  Cd Length: 274  Bit Score: 497.51  E-value: 5.15e-180
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21758308   6 AVMNYIFLLLCLCGLVGNGLVLWFFGFSIKRNPFSIYFLHLASADVGYLFSKAVFSILNTGGFLGTFADYIRSVCRVLGL 85
Cdd:cd15109   1 AVMNYIFLLLCLCGLVGNGLVLWFFGFSIKRNPFSIYFLHLASADVGYLFSKAVFSILNTGGFLGTFADYIRSVSRILGL 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21758308  86 CMFLTGVSLLPAVSAERCASVIFPAWYWRRRPKRLSAVVCALLWVLSLLVTCLHNYFCVFLGRGAPGAACRHMDIFLGIL 165
Cdd:cd15109  81 CTFLTGVSLLPAISIERCVSVIFPTWYWRRRPKRLSAVVCALLWMLSLLVTCIHNYFCVFLGREAPGAACRHMDIFLGIL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21758308 166 LFLLCCPLMVLPCLALILHVECRARRRQRSAKLNHVILAMVSVFLVSSIYLGIDWFLFWVFQIPAPFPEYVTDLCICINS 245
Cdd:cd15109 161 LFLLFCPLMVLPCLALILHVECRARRRQRSAKLNHVILAMVSVFLVSSIYLGIDWFLFWVFQIPAPFPEYVTDLCICINS 240
                       250       260       270
                ....*....|....*....|....*....|....
gi 21758308 246 SAKPIVYFLAGRDKSQRLWEPLRVVFQRALRDGA 279
Cdd:cd15109 241 SAKPIVYFLAGRDKSQRLWEPLRVVFQRALRDGA 274
7tmA_Mrgpr cd14973
mas-related G protein-coupled receptors, member of the class A family of seven-transmembrane G ...
23-279 1.30e-96

mas-related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined. Also included in this family is Mas-related G-protein coupled receptor 1-like (MAS1L) which is only found in primates. The angiotensin-II metabolite angiotensin is an endogenous ligand for MAS1L.


Pssm-ID: 320104 [Multi-domain]  Cd Length: 272  Bit Score: 286.07  E-value: 1.30e-96
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21758308  23 NGLVLWFFGFSIKRNPFSIYFLHLASADVGYLFSKAVFSILNTGGFLgTFADYIRSVCRVLGLCMFLTGVSLLPAVSAER 102
Cdd:cd14973  18 NGLVLWLLGFRIKRNPFSVYILNLAAADFLFLSCQAIQSLEDLLGGS-LPGFALCRLLATLMFFSYTVGLSLLAAISTER 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21758308 103 CASVIFPAWYWRRRPKRLSAVVCALLWVLSLLVTCLHNYFCVFLGRGAPGAACRHMDiFLGILLFLLCCPLMVLPCLALI 182
Cdd:cd14973  97 CLSVLFPIWYRCHRPKHLSAVVCALLWALSLLLSVLESYFCGFLFWKFNESACRTFN-FLSALLFLLLFLVMCVSSLTLL 175
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21758308 183 LHVECRARRRqRSAKLNHVILAMVSVFLVSSIYLGIDWFLFWVF-QIPAPFPEYVTDLCICINSSAKPIVYFLAGRDKSQ 261
Cdd:cd14973 176 IRVQCSSQRR-PPTRLYVVILLTVLVFLLCGLPLGIYWFLLLWFsNYLFHTFHPISDLLSCVNSSANPIIYFFVGSLRGR 254
                       250
                ....*....|....*...
gi 21758308 262 RLWEPLRVVFQRALRDGA 279
Cdd:cd14973 255 RLREPLRVVLQRALRDEP 272
7tmA_MrgprH cd15110
mas-related G protein-coupled receptor subtype H, member of the class A family of ...
23-279 2.16e-53

mas-related G protein-coupled receptor subtype H, member of the class A family of seven-transmembrane G protein-coupled receptors; The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined.


Pssm-ID: 320238  Cd Length: 274  Bit Score: 175.67  E-value: 2.16e-53
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21758308  23 NGLVLWFFGFSIKRNPFSIYFLHLASADVGYLFSKAVFSILNTG--GFLGTFADYIRSVCRVLGLCMFLTGVSLLPAVSA 100
Cdd:cd15110  18 NGIVLWFLGFRIRRNPFTVYILHLAIADFTFLLCIFILSIMYIGpfNFSHSRDYVAMLIFIILFLFGYNTGLYLLTAISV 97
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21758308 101 ERCASVIFPAWYWRRRPKRLSAVVCALLWVLSLLVTCLHNYFCVFLGRgAPGAACRHMDIFLGILLFLLCCPLMVLPCLA 180
Cdd:cd15110  98 ERCLSVLYPIWYRCHRPKHQSAIVCGLLWALSVLMTSLEYLMCIDEGF-HVRNECRAVLIFIGILTFLVFTPLMLISSLI 176
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21758308 181 LILHVECRARRRQrSAKLNHVILAMVSVFLVSSIYLGIDWFLFWVFQIPAPFPEYVTDLCICINSSAKPIVYFLAGRDKS 260
Cdd:cd15110 177 LFIKVRCNSQRRH-PGKLYIIIMLTVIFFLIFAMPMRVLLLLNYLHHSSFLFSNPVPFLLSTVNSSINPIVYFLVGSLRR 255
                       250
                ....*....|....*....
gi 21758308 261 QRLWEPLRVVFQRALRDGA 279
Cdd:cd15110 256 KRIKKSLKVALQRVFEDKA 274
7tmA_MrgprD cd15108
mas-related G protein-coupled receptor subtype D, member of the class A family of ...
23-277 2.30e-49

mas-related G protein-coupled receptor subtype D, member of the class A family of seven-transmembrane G protein-coupled receptors; The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined.


Pssm-ID: 320236  Cd Length: 276  Bit Score: 165.31  E-value: 2.30e-49
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21758308  23 NGLVLWFFGFSIKRNPFSIYFLHLASADVGYLFSKAVFSILNTGGfLGTFADYIRSVCRVLGLCMFLTGVSLLPAVSAER 102
Cdd:cd15108  18 NGLVVWLLSCRGRRTPFCVYVLHLAVADLLFLLCMASTLSLETSP-LVITHDLAYEVVRRVKYFAYTASLSLLTAISTQR 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21758308 103 CASVIFPAWYWRRRPKRLSAVVCALLWVLSLLVTCLHNYFCV-FLGRGApgAACRHMDIFLGILLFLLCCPLMVLPCLAL 181
Cdd:cd15108  97 CLSVLFPIWYKCHQPRHLSAVVCALLWALSLLMNVLASFFCSeFWHPDE--WQCFKVDMVFSFLIMGIFTPVMALSSLIL 174
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21758308 182 ILHVECRARRRQRS-AKLNHVILAMVSVFLVSSIYLGIDWF-LFWVfqipaPFPEYVTDLCIC-------INSSAKPIVY 252
Cdd:cd15108 175 FVRVRRSSRQWRRRpTRLYVVVLASVLVFLACALPLGIYWFlLYWL-----DLPQEVKTLFSClsrlsssVSSSANPVIY 249
                       250       260
                ....*....|....*....|....*
gi 21758308 253 FLAGRDKSQRLWEPLRVVFQRALRD 277
Cdd:cd15108 250 FLVGSRGSRRLREPLGAVLQRALRE 274
7tmA_MrgprE cd15112
mas-related G protein-coupled receptor subtype E, member of the class A family of ...
23-279 3.27e-41

mas-related G protein-coupled receptor subtype E, member of the class A family of seven-transmembrane G protein-coupled receptors; The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined.


Pssm-ID: 320240  Cd Length: 272  Bit Score: 143.82  E-value: 3.27e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21758308  23 NGLVLWFFGFSIKRNPFSIYFLHLASADVGYLFSKAVFSILNTGGFLGTFADYIRSVCRVLGLCMFLTGVSLLPAVSAER 102
Cdd:cd15112  18 NGLVLWLLSSNVYRNPFSIYLLDVACADLIFLCCHMVAIIPELLQNHLSFPHFVYDSLLALRFFCYIVGLSLLAAISAEQ 97
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21758308 103 CASVIFPAWYWRRRPKRLSAVVCALLWVLSLLVTCLHNYFCVFLGRGAPGAACRhMDIFLGILLFLLCCPLMVLPCLALI 182
Cdd:cd15112  98 CLATLFPAWYQCRRPRHLTTCVCALLWALCLLLHLLLSGACTQFFGGPSGHLCG-RLWLVRAVLLALLCCTMCVSSLVLL 176
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21758308 183 LHVECrARRRQRSAKLNHVILAMVSVFLVSSIYLGIDWF-LFWVFQIPAPFpEYVTDLCICINSSAKPIVYFLAGRDKSQ 261
Cdd:cd15112 177 LRVER-GPPRQRPRGFPALVLLTVLLFLFCGLPFGIYWLsLNLLWRIPHYF-YHFSFLMAAVHSAAKPPIYFCLGSLRGG 254
                       250
                ....*....|....*...
gi 21758308 262 RLWEPLRVVFQRALRDGA 279
Cdd:cd15112 255 RFREPLRLVLQRALGDEA 272
7tmA_MrgprX-like cd15106
primate-specific mas-related G protein-coupled receptor subtype X-like, member of the class A ...
23-277 5.56e-41

primate-specific mas-related G protein-coupled receptor subtype X-like, member of the class A family of seven-transmembrane G protein-coupled receptors; The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined.


Pssm-ID: 320234  Cd Length: 274  Bit Score: 143.35  E-value: 5.56e-41
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21758308  23 NGLVLWFFGFSIKRNPFSIYFLHLASADVGYLFSKAVFSILNTGGFLGTFadYIRSVCRVLGLCMFLTGVSLLPAVSAER 102
Cdd:cd15106  18 NAVVLWLLGFRMRRNAFSVYILNLAAADFLFLCCHIIDSLLRLINIFHII--SIPKILTNVMTFPYFAGLSMLSAISTER 95
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21758308 103 CASVIFPAWYWRRRPKRLSAVVCALLWVLSLLVTCLHNYFCVFLGRGAPGAACRHMDIFLGILLFLLCCPLMVlPCLALI 182
Cdd:cd15106  96 CLSVLWPIWYRCHRPRHLSAVVCVLLWALSLLLSILEWKFCGFLFSGADSHWCQTFDFITTAWLIFLFVVLCG-SSLALL 174
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21758308 183 LHVECRARRRQRSaKLNHVILAMVSVFLVSSIYLGIDWFLFWVFQIPAPFP----EYVTDLCICINSSAKPIVYFLAGRD 258
Cdd:cd15106 175 VRILCGSRKMPLT-RLYVTILLTVLVFLLCGLPFGIQWFLLLWIHIDLEVLfchvYLVSVVLSCLNSSANPIIYFFVGSF 253
                       250
                ....*....|....*....
gi 21758308 259 KSQRLWEPLRVVFQRALRD 277
Cdd:cd15106 254 RQRQNRQNLKLVLQRALQD 272
7tmA_MrgprB cd15107
mas-related G protein-coupled receptor subtype B, member of the class A family of ...
7-277 1.22e-38

mas-related G protein-coupled receptor subtype B, member of the class A family of seven-transmembrane G protein-coupled receptors; The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined.


Pssm-ID: 320235  Cd Length: 276  Bit Score: 137.14  E-value: 1.22e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21758308   7 VMNYIFLLLCLCGLVGNGLVLWFFGFSIKRNPFSIYFLHLASADVGYLFSKAVFSILNTGGFlGTFADYIRSVCRVLGLC 86
Cdd:cd15107   2 TMNFLSIIIALVGLAGNAIVLWLLGFHMHRNAFSVYILNLAGADFLFLCTQIVFSLEIVLQF-HSIDIHIPLFLLTVTMF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21758308  87 MFLTGVSLLPAVSAERCASVIFPAWYWRRRPKRLSAVVCALLWVLSLLVTCLHNYFCVFLGRGAPGAACRHMDIFLGILL 166
Cdd:cd15107  81 AYLAGLSMITAISIERCLSVMWPIWYHCQRPRHTSAVICTLLWVLSLLLSLLEGKGCGFLFSTYDYYWCWTLDLITTAWL 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21758308 167 FLlccpLMVLPC---LALILHVECRARRRQRSaKLNHVILAMVSVFLVSSIYLGIDWFLF-WV---FQIPAPFPEYVTDL 239
Cdd:cd15107 161 IV----LFVVLSgssLALLVRIFCGSHRIPVT-RLYVTIALTVLVFLIFGLPFGIYWFLLkWIeefYIVPCCGFYEVILF 235
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 21758308 240 CICINSSAKPIVYFLAGRDKSQRL-WEPLRVVFQRALRD 277
Cdd:cd15107 236 LSCVNSCANPIIYFLVGSIRHHRFqRKTLKLLLQRAMQD 274
7tmA_MrgprA cd15105
mas-related G protein-coupled receptor subtype A, member of the class A family of ...
23-277 1.39e-33

mas-related G protein-coupled receptor subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors; The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined.


Pssm-ID: 320233  Cd Length: 276  Bit Score: 124.09  E-value: 1.39e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21758308  23 NGLVLWFFGFSIKRNPFSIYFLHLASADVGYLFSKAVFSILNTGGFL---GTFADYIRSVCRVLglcmFLTGVSLLPAVS 99
Cdd:cd15105  18 NAIVFWLLGFRLHRNAFSVYILNLALADFLFLLCHIIDSTLLLLKVFypnIIFLPCFYTIMMVL----YITGLSMLSAIS 93
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21758308 100 AERCASVIFPAWYWRRRPKRLSAVVCALLWVLSLLVTCLHNYFCVFLG-RGAPGAACRHMDIFLGILLFLLCCpLMVLPC 178
Cdd:cd15105  94 TERCLSVLCPIWYRCRRPEHTSTVMCAVIWVLSLLICILNRYFCGFLDtKYENDSVCLASNFFTAAYLMFLFV-VLCLSS 172
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21758308 179 LALILHVECRARRRqRSAKLNHVILAMVSVFLVSSIYLGIDWFL-FWV--FQIPAPFPEYVTDLCI-CINSSAKPIVYFL 254
Cdd:cd15105 173 LALLARLFCGAGQM-KLTRLYVTIMLTVLVFLLCGLPFGIYWFLlFWIkdDFHVLDYGLYLASVVLtAVNSCANPIIYFF 251
                       250       260
                ....*....|....*....|...
gi 21758308 255 AGRDKSQRLWEPLRVVFQRALRD 277
Cdd:cd15105 252 VGSFRHRLKHQTLKMVLQSALQD 274
7tmA_MrgprG cd15111
mas-related G protein-coupled receptor subtype G, member of the class A family of ...
23-279 1.42e-31

mas-related G protein-coupled receptor subtype G, member of the class A family of seven-transmembrane G protein-coupled receptors; The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined.


Pssm-ID: 320239  Cd Length: 263  Bit Score: 118.35  E-value: 1.42e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21758308  23 NGLVLWFFGFSIKRNPFSIYFLHLASADVGYLFSKAVFSILNTGgfLGTfADYIRSVCRVLGlcmFLTGVSLLPAVSAER 102
Cdd:cd15111  18 NGLVLWHLGFHIKKGPFSNYLLHLAAADFLFLSCQVGFSIAQAA--LGS-EDTLYFVVTFLW---FAAGLWLLAAFSVER 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21758308 103 CASVIFPAWYWRRRPKRLSAVVCALLWVLSLLVTCLHNYFCVFLGRGAPGAACRHMDIFLGILlfllccpLMVLPCLA-- 180
Cdd:cd15111  92 CLSYLFPACCQGCRPRWTSAVLCAVVWVLTLPAVLLPANACGLLRNGSRLLVCLRYHAASVTW-------LLVLACVAcg 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21758308 181 ----LILHVECRARRRQrsAKLNHVILAMVSVFLVSSIYLGIDWFLFWVFQIPAPFPEYVTDLCICINSSAKPIVYFLAG 256
Cdd:cd15111 165 aglvLFIWVCCCSQRPR--PKFYGIVLGSGLLLLFCGLPFVLYWSLRPLLNFLLPMFPPLATLLACIDSSSKPLIYYLMG 242
                       250       260
                ....*....|....*....|...
gi 21758308 257 RDKSQRlwEPLRVVFQRALRDGA 279
Cdd:cd15111 243 RQPGKR--EPLRVVLQRALGEGA 263
7tmA_MAS1L cd15113
mas-related G protein-coupled receptor 1-like (MAS1L), member of the class A family of ...
23-277 1.22e-21

mas-related G protein-coupled receptor 1-like (MAS1L), member of the class A family of seven-transmembrane G protein-coupled receptors; MAS1L is also called MAS1 oncogene-like (MAS1-like) or mas-related G-protein coupled receptor MRG. MAS1L is a G protein-coupled receptor that only found in primates. The angiotensin-II metabolite angiotensin is an endogenous ligand for MAS1L. The Mas-related G-protein coupled receptor (Mrgpr) family constitutes a group of orphan receptors exclusively expressed in nociceptive primary sensory neurons and mast cells in the skin. Members of the Mrgpr family have been implicated in the modulation of nociception, pruritus (itching), and mast cell degranulation. The Mrgpr family in rodents and humans contains more than 50 members that can be grouped into 9 distinct subfamilies: MrgprA, B, C (MrgprX1), D, E, F, G, H (GPR90), and the primate-specific MrgprX subfamily. Some Mrgprs can be activated by endogenous ligands such as beta-alanine, adenine (a cell metabolite and potential transmitter), RF-amide related peptides, or salusin-beta (a bioactive peptide). However, the effects of these agonists are not clearly understood, and the physiological role of the individual receptor family members remains to be determined.


Pssm-ID: 320241  Cd Length: 265  Bit Score: 91.82  E-value: 1.22e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21758308  23 NGLVLWFFGFSIKRNPFSIYFLHLASADVGYLFSKAVFSILNTGGFLGTFADYIRSVCRVLGLCMFLTGVSLLPAVSAER 102
Cdd:cd15113  18 NGVVFWLLCCGVRSNPYMVYILNLAAADVINLSCSAVILLEVTLLLYHGVTLFVADFLEPVSYFSDTVGLCLLVAISTES 97
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21758308 103 CASVIFPAWYWrRRPKRLSAVVCALLWVLSLlvtCLHNYFCVFLgRGAPGAACRHMDIFLGILLFLLCCpLMVLPCLALI 182
Cdd:cd15113  98 CLCVLFPIWCC-HRPKYTSAVVSTLSWGLPL---SLHIVKSLCL-YWEHGLACDIFHKGFGIFHALISL-VMCVSSLTLT 171
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21758308 183 LHVECrARRRQRSAKLNHVILAMVSVFLVSSIYLGIDWFLfwVFQIPAPFPEYVTDLCICINSSAKPIVYFLAGRDKSQR 262
Cdd:cd15113 172 IRSLC-CSQQCSATRIYHVVRISAIMFLLWGLPLVVAPLL--PDFEYLTTTFDLLLLLSIIVSSANPIIYFLVGSLRRKR 248
                       250
                ....*....|....*
gi 21758308 263 LWEPLRVVFQRALRD 277
Cdd:cd15113 249 LKESLKVILQRALAD 263
7tmA_Anaphylatoxin_R-like cd14974
anaphylatoxin receptors and related G protein-coupled chemokine receptors, member of the class ...
23-263 1.66e-13

anaphylatoxin receptors and related G protein-coupled chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily of G-protein coupled receptors includes anaphylatoxin receptors, formyl peptide receptors (FPR), prostaglandin D2 receptor 2, GPR1, and related chemokine receptors. The anaphylatoxin receptors are a group of G-protein coupled receptors that bind anaphylatoxins. The members of this group include C3a and C5a receptors. The formyl peptide receptors (FPRs) are chemoattractant GPCRs that involved in mediating immune responses to infection. They are expressed mainly on polymorphonuclear and mononuclear phagocytes and bind N-formyl-methionyl peptides (FMLP), which are derived from the mitochondrial proteins of ruptured host cells or invading pathogens. Chemokine receptor-like 1 (also known as chemerin receptor 23) is a GPCR for the chemoattractant adipokine chemerin, also known as retinoic acid receptor responder protein 2 (RARRES2), and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with chemerin induces activation of the MAPK and PI3K signaling pathways leading to downstream functional effects, such as a decrease in immune responses, stimulation of adipogenesis, and angiogenesis. On the other hand, resolvin E1 negatively regulates the cytokine production in macrophages by reducing the activation of MAPK1/3 and NF-kB pathways. Prostaglandin D2 receptor, also known as CRTH2, is a chemoattractant G-protein coupled receptor expressed on T helper type 2 cells that binds prostaglandin D2 (PGD2). PGD2 functions as a mast cell-derived mediator to trigger asthmatic responses and also causes vasodilation. PGD2 exerts its inflammatory effects by binding to two G-protein coupled receptors, the D-type prostanoid receptor (DP) and PD2R2 (CRTH2). PD2R2 couples to the G protein G(i/o) type which leads to a reduction in intracellular cAMP levels and an increase in intracellular calcium. GPR1 is an orphan receptor that can be activated by the leukocyte chemoattractant chemerin, thereby suggesting that some of the anti-inflammatory actions of chemerin may be mediated through GPR1.


Pssm-ID: 320105 [Multi-domain]  Cd Length: 274  Bit Score: 69.25  E-value: 1.66e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21758308  23 NGLVLWFFGFSIKRNPFSIYFLHLASADVgyLFSkAVFSILNTGGFLGTFADYIRSVCRVLGLCMFLT---GVSLLPAVS 99
Cdd:cd14974  18 NGLVIWVAGFKMKRTVNTVWFLNLALADF--LFC-LFLPFLIVYIAMGHHWPFGSVLCKLNSFVISLNmfaSVFLLTAIS 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21758308 100 AERCASVIFPAWYWRRRPKRLSAVVCALLWVLSLLVTCLHNYFCVFLGRGAPGAAC------------RHMDIFLGILLF 167
Cdd:cd14974  95 LDRCLLVLHPVWAQNHRTVRLASVVCVGIWILALVLSVPYFVFRDTVTHHNGRSCNltcvedydlrrsRHKALTVIRFLC 174
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21758308 168 LLCCPLMVLPCLALILHVECRARRRQRSAKLNHVILAMVSVFLVSsiylgidWFLFWVFQI----PAPFPEYVTDLCI-- 241
Cdd:cd14974 175 GFLLPLLIIAICYSVIAVKLRRKRLAKSSKPLRVLLAVVVAFFLC-------WLPYHVFALlelvAAAGLPEVVLLGLpl 247
                       250       260
                ....*....|....*....|....*..
gi 21758308 242 -----CINSSAKPIVYFLAGRDKSQRL 263
Cdd:cd14974 248 atglaYFNSCLNPILYVFMGQDFRKRL 274
7tmA_CMKLR1 cd15116
chemokine-like receptor 1, member of the class A family of seven-transmembrane G ...
23-258 3.44e-12

chemokine-like receptor 1, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokine receptor-like 1 (also known as Chemerin receptor 23) is a GPCR for the chemoattractant adipokine chemerin, also known as retinoic acid receptor responder protein 2 (RARRES2), and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with chemerin induces activation of the MAPK and PI3K signaling pathways leading to downstream functional effects, such as a decrease in immune responses, stimulation of adipogenesis, and angiogenesis. On the other hand, resolvin E1 negatively regulates the cytokine production in macrophages by reducing the activation of MAPK1/3 and NF-kB pathways. CMKLR1 is prominently expressed in dendritic cells and macrophages.


Pssm-ID: 320244 [Multi-domain]  Cd Length: 284  Bit Score: 65.55  E-value: 3.44e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21758308  23 NGLVLWFFGFSIKRNPFSIYFLHLASADvgYLFSKAV-FSILNTGgfLGTFADYIRSVCRVLGLCMFL---TGVSLLPAV 98
Cdd:cd15116  18 NGLVIFITGFKMKKTVNTVWFLNLAVAD--FLFTFFLpFSIAYTA--MDFHWPFGRFMCKLNSFLLFLnmfTSVFLLTVI 93
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21758308  99 SAERCASVIFPAWYWRRRPKRLSAVVCALLWVLSLLVTCLHNYF-------------CV----FLGRGA-----PGAACR 156
Cdd:cd15116  94 SIDRCISVVFPVWSQNHRSVRLASLVSLAVWVVAFFLSSPSFIFrdtapsqnnnkiiCFnnfsLSGDNSspevnQLRNMR 173
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21758308 157 HMDIFLGILLFLLCCPLMVLPCLALILHVECRARRRQRSAKLNHVILAMVSVF--------LVSSIYLGIDWFLFWVFQI 228
Cdd:cd15116 174 HQVMTITRFLLGFLIPFTIIICCYAAIVLKLKRNRLAKSSKPFKIIAAVIVTFflcwapyhILNLLEMEATRSPASVFKI 253
                       250       260       270
                ....*....|....*....|....*....|
gi 21758308 229 PAPfpeyVTDLCICINSSAKPIVYFLAGRD 258
Cdd:cd15116 254 GLP----ITSSLAFINSCLNPILYVFMGQD 279
7tm_classA_rhodopsin-like cd00637
rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...
23-254 7.33e-11

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410626 [Multi-domain]  Cd Length: 275  Bit Score: 61.54  E-value: 7.33e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21758308  23 NGLVLWFFGFSIK-RNPFSIYFLHLASADVGYLFSKAVFSILNTGGFLGTFADYirsVCRVLGLCMFLTG---VSLLPAV 98
Cdd:cd00637  16 NLLVILVILRNRRlRTVTNYFILNLAVADLLVGLLVIPFSLVSLLLGRWWFGDA---LCKLLGFLQSVSLlasILTLTAI 92
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21758308  99 SAERCASVIFPAWYWRRRPKRLSAVVCALLWVLSLLVTC--LHNYFCVFLGRGAPGAACRHMDIFLGILLFLLCCPLMVL 176
Cdd:cd00637  93 SVDRYLAIVHPLRYRRRFTRRRAKLLIALIWLLSLLLALppLLGWGVYDYGGYCCCCLCWPDLTLSKAYTIFLFVLLFLL 172
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21758308 177 PCLALIL--------------------HVECRARRRQRSAKLNHVILAMVSVFLVSSIYLGIDWFLFWVFQIPAPFPEYV 236
Cdd:cd00637 173 PLLVIIVcyvrifrklrrhrrrirsssSNSSRRRRRRRERKVTKTLLIVVVVFLLCWLPYFILLLLDVFGPDPSPLPRIL 252
                       250       260
                ....*....|....*....|.
gi 21758308 237 TDLCIC---INSSAKPIVYFL 254
Cdd:cd00637 253 YFLALLlayLNSAINPIIYAF 273
7tm_1 pfam00001
7 transmembrane receptor (rhodopsin family); This family contains, amongst other ...
23-142 1.04e-09

7 transmembrane receptor (rhodopsin family); This family contains, amongst other G-protein-coupled receptors (GCPRs), members of the opsin family, which have been considered to be typical members of the rhodopsin superfamily. They share several motifs, mainly the seven transmembrane helices, GCPRs of the rhodopsin superfamily. All opsins bind a chromophore, such as 11-cis-retinal. The function of most opsins other than the photoisomerases is split into two steps: light absorption and G-protein activation. Photoisomerases, on the other hand, are not coupled to G-proteins - they are thought to generate and supply the chromophore that is used by visual opsins.


Pssm-ID: 459624 [Multi-domain]  Cd Length: 256  Bit Score: 58.08  E-value: 1.04e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21758308    23 NGLVLWFFGFSIK-RNPFSIYFLHLASADVGY----LFSKAVFSILNTGGFLGTFadyirsVCRVLGLCMFLTGVS---L 94
Cdd:pfam00001   2 NLLVILVILRNKKlRTPTNIFLLNLAVADLLFslltLPFWLVYYLNHGDWPFGSA------LCKIVGALFVVNGYAsilL 75
                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 21758308    95 LPAVSAERCASVIFPAWYWRRRPKRLSAVVCALLWVLSLLVTCLHNYF 142
Cdd:pfam00001  76 LTAISIDRYLAIVHPLRYKRRRTPRRAKVLILVIWVLALLLSLPPLLF 123
7tmA_PD2R2_CRTH2 cd15118
prostaglandin D2 receptor, member of the class A family of seven-transmembrane G ...
23-211 1.16e-09

prostaglandin D2 receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostaglandin D2 receptor, also known as CRTH2, is a chemoattractant G-protein coupled receptor expressed on T helper type 2 cells that binds prostaglandin D2 (PGD2). PGD2 functions as a mast cell-derived mediator to trigger asthmatic responses and also causes vasodilation. PGD2 exerts its inflammatory effects by binding to two G-protein coupled receptors, the D-type prostanoid receptor (DP) and PD2R2 (CRTH2). PD2R2 couples to the G protein G(i/o) type which leads to a reduction in intracellular cAMP levels and an increase in intracellular calcium. PD2R2 is involved in mediating chemotaxis of Th2 cells, eosinophils, and basophils generated during allergic inflammatory processes. CRTH2 (PD2R2), but not DP receptor, undergoes agonist-induced internalization which is one of key processes that regulates the signaling of the GPCR.


Pssm-ID: 320246 [Multi-domain]  Cd Length: 284  Bit Score: 57.89  E-value: 1.16e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21758308  23 NGLVLWFFGFSIKRNPFSIYFLHLASADVGYLFSKAVFSILNTGGF---LGTFADYIRSvcRVLGLCMFLTGVsLLPAVS 99
Cdd:cd15118  18 NLLILWVVGFRLRRTVISIWILNLALSDLLATLSLPFFTYYLASGHtweLGTTFCRIHS--SIFFLNMFVSGF-LLAAIS 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21758308 100 AERCASVIFPAWYWRRRPKRLSAVVCALLWVLSLLVT------------------CLHNYFCVFLGRGAPGAAC--RHMD 159
Cdd:cd15118  95 LDRCLLVVKPVWAQNHRNVAAAKKICGVIWAMALINTipyfvfrdvierkdgrklCYYNFALFSPSPDNNHPICkqRQEG 174
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|..
gi 21758308 160 IFLGILLFLLCCPLMVLPCLALILHVECRARRRQRSAKLNHVILAMVSVFLV 211
Cdd:cd15118 175 LAISKLLLAFLIPLVIIAVSYAVVSLIIRHRCRRRPGRFVRLVVSVVVSFAL 226
7tmA_C3aR cd15115
complement component 3a anaphylatoxin chemotactic receptors, member of the class A family of ...
23-211 1.87e-09

complement component 3a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The anaphylatoxin receptors are a group of G-protein coupled receptors which bind anaphylatoxins; members of this group include C3a receptors and C5a receptors. Anaphylatoxins are also known as complement peptides (C3a, C4a and C5a) that are produced from the activation of the complement system cascade. These complement anaphylatoxins can trigger degranulation of endothelial cells, mast cells, or phagocytes, which induce a local inflammatory response and stimulate smooth muscle cell contraction, histamine release, and increased vascular permeability. They are potent mediators involved in chemotaxis, inflammation, and generation of cytotoxic oxygen-derived free radicals. In humans, a single receptor for C3a (C3AR1) and two receptors for C5a (C5AR1 and C5AR2, also known as C5L2 or GPR77) have been identified, but there is no known receptor for C4a.


Pssm-ID: 320243 [Multi-domain]  Cd Length: 265  Bit Score: 57.09  E-value: 1.87e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21758308  23 NGLVLWFFGFSIKRNPFSIYFLHLASADVGYLFSKAvFSILNTggFLGTFADYIRSVCRVLG----LCMFLTgVSLLPAV 98
Cdd:cd15115  18 NGLVIWVAGLKMKRTVNTIWFLNLAVADLLCCLSLP-FSIAHL--LLNGHWPYGRFLCKLLPsiivLNMFAS-VFTLTAI 93
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21758308  99 SAERCASVIFPAWYWRRRPKRLSAVVCALLWVLSLLVTC-LHNYFCVFLGRGAPGAACRHMDIFLGILLFL-LCCPLM-V 175
Cdd:cd15115  94 SLDRFLLVIKPVWAQNHRSVLLACLLCGCIWILALLLCLpVFIYRTTVTDGNHTRCGYDFLVAITITRAVFgFLLPLLiI 173
                       170       180       190
                ....*....|....*....|....*....|....*.
gi 21758308 176 LPCLALILHVECRARRRQRSAKLNHVILAMVSVFLV 211
Cdd:cd15115 174 AACYSFIAFRMQRGRFAKSQSKTFRVIIAVVVAFFV 209
7tmA_Angiotensin_R-like cd14985
angiotesin receptor family and its related G protein-coupled receptors, member of the class A ...
23-257 1.16e-08

angiotesin receptor family and its related G protein-coupled receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes the angiotensin receptors, the bradykinin receptors, apelin receptor as well as putative G-protein coupled receptors (GPR15 and GPR25). Angiotensin II (Ang II), the main effector in the renin-angiotensin system, plays a crucial role in the regulation of cardiovascular homeostasis through its type 1 (AT1) and type 2 (AT2) receptors. Ang II contributes to cardiovascular diseases such as hypertension and atherosclerosis via AT1R activation. Ang II increases blood pressure through Gq-mediated activation of phospholipase C, resulting in phosphoinositide (PI) hydrolysis and increased intracellular calcium levels. Through the AT2 receptor, Ang II counteracts the vasoconstrictor action of AT1R and thereby induces vasodilation, sodium excretion, and reduction of blood pressure. Bradykinins (BK) are pro-inflammatory peptides that mediate various vascular and pain responses to tissue injury through its B1 and B2 receptors. Apelin (APJ) receptor binds the endogenous peptide ligands, apelin and Toddler/Elabela. APJ is an adipocyte-derived hormone that is ubiquitously expressed throughout the human body, and Toddler/Elabela is a short secretory peptide that is required for normal cardiac development in zebrafish. Activation of APJ receptor plays key roles in diverse physiological processes including vasoconstriction and vasodilation, cardiac muscle contractility, angiogenesis, and regulation of water balance and food intake. Orphan receptors, GPR15 and GPR25, share strong sequence homology to the angiotensin II type AT1 and AT2 receptors.


Pssm-ID: 341320 [Multi-domain]  Cd Length: 284  Bit Score: 55.08  E-value: 1.16e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21758308  23 NGLVLWFFGFSIK-RNPFSIYFLHLASADVGYLFSKAVFSILNTGGFLGTFADYIrsvCRVLGLCMFLT---GVSLLPAV 98
Cdd:cd14985  18 NLFVVWVFLFPRGpKRVADIFIANLAAADLVFVLTLPLWATYTANQYDWPFGAFL---CKVSSYVISVNmfaSIFLLTCM 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21758308  99 SAERCASVIFPAWYWRRRPKRLSAVVCALLWVLSLLVTclhnyFCVFLGRG--------------APGAACRHMDIFLGI 164
Cdd:cd14985  95 SVDRYLAIVHPVASRRLRRRRQARVTCALIWVVACLLS-----LPTFLLRSlqaienlnktacimLYPHEAWHFGLSLEL 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21758308 165 LLFLLCCPLMV-LPCLALILHVECRARRRQ-----RSAKLNHVILAMVSVFLVSSI---YLGIDWFLFWVFQIPAPFPEY 235
Cdd:cd14985 170 NILGFVLPLLIiLTCYFHIARSLRKRYERTgkngrKRRKSLKIIFALVVAFLVCWLpfhFFKFLDFLAQLGAIRPCFWEL 249
                       250       260
                ....*....|....*....|....*....
gi 21758308 236 VTDL----CICI---NSSAKPIVYFLAGR 257
Cdd:cd14985 250 FLDLglpiATCLaftNSCLNPFIYVFVDR 278
7tmA_purinoceptor-like cd14982
purinoceptor and its related proteins, member of the class A family of seven-transmembrane G ...
23-136 1.21e-08

purinoceptor and its related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; Members of this subfamily include lysophosphatidic acid receptor, P2 purinoceptor, protease-activated receptor, platelet-activating factor receptor, Epstein-Barr virus induced gene 2, proton-sensing G protein-coupled receptors, GPR35, and GPR55, among others. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 341318 [Multi-domain]  Cd Length: 283  Bit Score: 54.96  E-value: 1.21e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21758308  23 NGLVLWFFGFSIK-RNPFSIYFLHLASADVGYLFS---KAVFSILNTGGFLGTFadyirsVCRVLGLCMFLT---GVSLL 95
Cdd:cd14982  18 NILALWVFLRKMKkRSPTTIYMINLALADLLFVLTlpfRIYYYLNGGWWPFGDF------LCRLTGLLFYINmygSILFL 91
                        90       100       110       120
                ....*....|....*....|....*....|....*....|.
gi 21758308  96 PAVSAERCASVIFPAWYWRRRPKRLSAVVCALLWVLSLLVT 136
Cdd:cd14982  92 TCISVDRYLAVVHPLKSRRLRRKRYAVGVCAGVWILVLVAS 132
7tmA_GPR1 cd15119
G protein-coupled receptor 1 for chemerin, member of the class A family of seven-transmembrane ...
23-257 3.23e-08

G protein-coupled receptor 1 for chemerin, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor 1 (GPR1) belongs to the class A of the seven transmembrane domain receptors. This is an orphan receptor that can be activated by the leukocyte chemoattractant chemerin, thereby suggesting that some of the anti-inflammatory actions of chemerin may be mediated through GPR1. GPR1 is most closely related to another chemerin receptor CMKLR1. In an in-vitro study, GPR1 has been shown to act as a co-receptor to allow replication of HIV viruses.


Pssm-ID: 320247 [Multi-domain]  Cd Length: 278  Bit Score: 53.59  E-value: 3.23e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21758308  23 NGLVLWFFGFSIKRNPFSIYFLHLASADVGYLFSKAVFSILNTGGFLGTFADYIRSVCRVLGLCMFLTGVSLLPAVSAER 102
Cdd:cd15119  18 NAIVIWVTGFKWKKTVNTLWFLNLAIADFVFVLFLPLHITYVALDFHWPFGVWLCKINSFVAVLNMFASVLFLTVISLDR 97
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21758308 103 CASVIFPAWYWRRRPKRLSAVVCALLWVLSLLVTCLHNYF------------CV--FLGRGAPGAACRHMDIFLGILLFL 168
Cdd:cd15119  98 YISLAHPVWSHRYRTLKSALILCGIVWLSAAAISGPALYFrdtmelsinvtiCFnnFHKHDGDLIVMRHTILVWVRFFFG 177
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21758308 169 LCCPLMVLPCLALILHVECRARRRQRSAKLNHVILAMVSVFLV--------SSIYLGI--DWFLFWVFQIPAPFPEYVTD 238
Cdd:cd15119 178 FLFPLLTMVVCYSLLAIKVKRRTLLISSKFFWTISAVIVAFFVcwtpyhifSILELSIhhSSYLHNVLRAGIPLATSLAF 257
                       250
                ....*....|....*....
gi 21758308 239 LCICINssakPIVYFLAGR 257
Cdd:cd15119 258 INSCLN----PILYVLIGK 272
7tmA_FPR-like cd15117
N-formyl peptide receptors, member of the class A family of seven-transmembrane G ...
23-263 5.16e-08

N-formyl peptide receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The formyl peptide receptors (FPRs) are chemoattractant GPCRs that involved in mediating immune responses to infection. They are expressed at elevated levels on polymorphonuclear and mononuclear phagocytes. FPRs bind N-formyl peptides, which are derived from the mitochondrial proteins of ruptured host cells or invading pathogens. Activation of FPRs by N-formyl peptides such as N-formyl-Met-Leu-Phe (FMLP) triggers a signaling cascade that stimulates neutrophil accumulation, phagocytosis and superoxide production. These responses are mediated through a pertussis toxin-sensitive G(i) protein that activates a PLC-IP3-calcium signaling pathway. While FPRs are involved in host defense responses to bacterial infection, they can also suppress the immune system under certain conditions. Yet, the physiological role of the FPR family is not fully understood.


Pssm-ID: 320245 [Multi-domain]  Cd Length: 288  Bit Score: 53.20  E-value: 5.16e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21758308  23 NGLVLWFFGFSIKRNPFSIYFLHLASADVGYLFSKAVFSILNTGGFLGTFADYIRSVCRVLGLCMFLTGVSLLPAVSAER 102
Cdd:cd15117  18 NGLVIWVTGFRMTRTVTTVCFLNLAVADFAFCLFLPFSVVYTALGFHWPFGWFLCKLYSTLVVFNLFASVFLLTLISLDR 97
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21758308 103 CASVIFPAWYWRRRPKRLSAVVCALLWVLSLLVTCLHNYF-----------CVF-----------LGRGAPGAACRHMDI 160
Cdd:cd15117  98 CVSVLWPVWARNHRTPARAALVAVGAWLLALALSGPHLVFrdtrkengcthCYLnfdpwnetaedPVLWLETVVQRLSAQ 177
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21758308 161 FLGILLFLLCCPLMVLP-CLALILHVECRaRRRQRSAKLNHVILAMVSVF--------LVSSIYLGIDWFLFWVFQIPAP 231
Cdd:cd15117 178 VITRFVLGFLVPLVIIGgCYGLIAARLWR-EGWVHSSRPFRVLTAVVAAFflcwfpfhLVSLLELVVILNQKEDLNPLLI 256
                       250       260       270
                ....*....|....*....|....*....|..
gi 21758308 232 FPEYVTDLCICINSSAKPIVYFLAGRDKSQRL 263
Cdd:cd15117 257 LLLPLSSSLACVNSCLNPLLYVFVGRDFRERL 288
7tmA_C5aR cd15114
complement component 5a anaphylatoxin chemotactic receptors, member of the class A family of ...
23-136 2.32e-07

complement component 5a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; The anaphylatoxin receptors are a group of G-protein coupled receptors which bind anaphylatoxins; members of this group include C3a receptors and C5a receptors. Anaphylatoxins are also known as complement peptides (C3a, C4a and C5a) that are produced from the activation of the complement system cascade. These complement anaphylatoxins can trigger degranulation of endothelial cells, mast cells, or phagocytes, which induce a local inflammatory response and stimulate smooth muscle cell contraction, histamine release, and increased vascular permeability. They are potent mediators involved in chemotaxis, inflammation, and generation of cytotoxic oxygen-derived free radicals. In humans, a single receptor for C3a (C3AR1) and two receptors for C5a (C5AR1 and C5AR2, also known as C5L2 or GPR77) have been identified, but there is no known receptor for C4a.


Pssm-ID: 320242 [Multi-domain]  Cd Length: 274  Bit Score: 51.25  E-value: 2.32e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21758308  23 NGLVLWFFGFSIKRNPFSIYFLHLASADvgyLFSKAVFSILNTGGFLGTFADYIRSVCRVLG---LCMFLTGVSLLPAVS 99
Cdd:cd15114  18 NALVAWVTGFEAKRSVNAVWFLNLAVAD---LLCCLSLPILAVPIAQDGHWPFGAAACKLLPsliLLNMYASVLLLTAIS 94
                        90       100       110
                ....*....|....*....|....*....|....*..
gi 21758308 100 AERCASVIFPAWYWRRRPKRLSAVVCALLWVLSLLVT 136
Cdd:cd15114  95 ADRCLLVLRPVWCQNHRRARLAWIACGAAWLLALLLT 131
7tmA_P2Y1-like cd15168
P2Y purinoceptors 1, 2, 4, 6, 11 and similar proteins, member of the class A family of ...
23-263 3.72e-07

P2Y purinoceptors 1, 2, 4, 6, 11 and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14). This cluster only includes P2Y1-like receptors as well as other closely related orphan receptors, such as GPR91 (a succinate receptor) and GPR80/GPR99 (an alpha-ketoglutarate receptor).


Pssm-ID: 341329 [Multi-domain]  Cd Length: 284  Bit Score: 50.39  E-value: 3.72e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21758308  23 NGLVLWFFGFSIKR-NPFSIYFLHLASADVGYLFSK---AVFSILNTGGFLGTFAdyIRSVcRVLGLCMFLTGVSLLPAV 98
Cdd:cd15168  18 NSVVLYRFIFHLKPwNSSAIYMFNLAVSDLLYLLSLpflIYYYANGDHWIFGDFM--CKLV-RFLFYFNLYGSILFLTCI 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21758308  99 SAERCASVIFPAWYWRRRPKRLSAVVCALLWVLSLLVTCLHNYFC---------VFLGRGAPGAACRHMDIFLGILLFLL 169
Cdd:cd15168  95 SVHRYLGICHPLRSLGKLKKRHAVAISVAVWILVLLQLLPILFFAttgrknnrtTCYDTTSPEELNDYVIYSMVLTGLGF 174
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21758308 170 CCPLMV-LPCLALILHVECR-------ARRRQRSAKLNHVILAMVSVFLV-----SSIYLGIdWFLFW-----VFQIPAP 231
Cdd:cd15168 175 LLPLLIiLACYGLIVRALIRklgegvtSALRRKSIRLVIIVLALFAVCFLpfhvtRTINLAA-RLLSGtascaTLNGIYV 253
                       250       260       270
                ....*....|....*....|....*....|..
gi 21758308 232 FPEyVTDLCICINSSAKPIVYFLAGRDKSQRL 263
Cdd:cd15168 254 AYK-VTRPLASLNSCLNPLLYFLAGDKFRRRL 284
7tmA_GPR33 cd15120
orphan receptor GPR33, member of the class A family of seven-transmembrane G protein-coupled ...
23-134 9.22e-07

orphan receptor GPR33, member of the class A family of seven-transmembrane G protein-coupled receptors; G-protein coupled receptor GPR33, an orphan member of the chemokine-like receptor family, was originally identified as a pseudogene in humans as well as in several apes and rodent species. Although the intact GPR33 allele is still present in a small fraction of the human population, the human GPR33 contains a premature stop codon. The amino acid sequence of GPR33 shares a high degree of sequence identity with the members of the chemokine and chemoattractant receptors that control leukocyte chemotaxis. The human GPR33 is expressed in spleen, lung, heart, kidney, pancreas, thymus, gonads, and leukocytes.


Pssm-ID: 320248 [Multi-domain]  Cd Length: 282  Bit Score: 49.39  E-value: 9.22e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21758308  23 NGLVLWFFGFSIKRNPFSIYFLHLASAdvgYLFSKAVFSILNTGGFLGTFADYIRSVCRV----LGLCMFlTGVSLLPAV 98
Cdd:cd15120  18 NGLYLWVLGFKMRRTVNTLWFLHLILS---NLIFTLILPFMAVHVLMDNHWAFGTVLCKVlnstLSVGMF-TSVFLLTAI 93
                        90       100       110
                ....*....|....*....|....*....|....*.
gi 21758308  99 SAERCASVIFPAWYWRRRPKRLSAVVCALLWVLSLL 134
Cdd:cd15120  94 SLDRYLLTLHPVWSRQHRTNRWASAIVLGVWISAIL 129
7tmA_Opsins_type2_animals cd14969
type 2 opsins in animals, member of the class A family of seven-transmembrane G ...
23-138 1.55e-05

type 2 opsins in animals, member of the class A family of seven-transmembrane G protein-coupled receptors; This rhodopsin family represents the type 2 opsins found in vertebrates and invertebrates except sponge. Type 2 opsins primarily function as G protein coupled receptors and are responsible for vision as well as for circadian rhythm and pigment regulation. On the contrary, type 1 opsins such as bacteriorhodopsin and proteorhodopsin are found in both prokaryotic and eukaryotic microbes, functioning as light-gated ion channels, proton pumps, sensory receptors and in other unknown functions. Although these two opsin types share seven-transmembrane domain topology and a conserved lysine reside in the seventh helix, type 1 opsins do not activate G-proteins and are not evolutionarily related to type 2. Type 2 opsins can be classified into six distinct subfamilies including the vertebrate opsins/encephalopsins, the G(o) opsins, the G(s) opsins, the invertebrate G(q) opsins, the photoisomerases, and the neuropsins.


Pssm-ID: 381741 [Multi-domain]  Cd Length: 284  Bit Score: 45.66  E-value: 1.55e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21758308  23 NGLVLWFFGFSIK-RNPFSIYFLHLASAD-----VGYLFSkaVFSILNTGGFLGTFadyirsVCRVLGLCMFLTGV---S 93
Cdd:cd14969  18 NGLVIIVFLKKKKlRTPLNLFLLNLALADllmsvVGYPLS--FYSNLSGRWSFGDP------GCVIYGFAVTFLGLvsiS 89
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*
gi 21758308  94 LLPAVSAERCASVIFPAWYWRRRPKRlSAVVCALLWVLSLLVTCL 138
Cdd:cd14969  90 TLAALAFERYLVIVRPLKAFRLSKRR-ALILIAFIWLYGLFWALP 133
7tmA_Chemokine_R cd14984
classical and atypical chemokine receptors, member of the class A family of ...
23-212 2.28e-05

classical and atypical chemokine receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines. In addition to these classical chemokine receptors, there exists a subfamily of atypical chemokine receptors (ACKRs) that are unable to couple to G-proteins and, instead, they preferentially mediate beta-arrestin dependent processes, such as receptor internalization, after ligand binding. The classical chemokine receptors contain a conserved DRYLAIV motif in the second intracellular loop, which is required for G-protein coupling. However, the ACKRs lack this conserved motif and fail to couple to G-proteins and induce classical GPCR signaling. Five receptors have been identified for the ACKR family, including CC-chemokine receptors like 1 and 2 (CCRL1 and CCRL2), CXCR7, Duffy antigen receptor for chemokine (DARC), and D6. Both ACKR1 (DARC) and ACKR3 (CXCR7) show low sequence homology to the classic chemokine receptors.


Pssm-ID: 341319 [Multi-domain]  Cd Length: 278  Bit Score: 44.90  E-value: 2.28e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21758308  23 NGLVLWFFGFSIK-RNPFSIYFLHLASADVGYLFSKAVFSI-LNTGGFLGTFadyirsVCRVLGLCM---FLTGVSLLPA 97
Cdd:cd14984  18 NSLVLLVLLYYRKlRSMTDVYLLNLALADLLFVLTLPFWAVyAADGWVFGSF------LCKLVSALYtinFYSGILFLAC 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21758308  98 VSAERCASVIFPAWYWRRRPKRLSAVVCALLWVLSLLVTCLHNYFC-VFLGRGA-------PGAACRHMDIFLGILLFLL 169
Cdd:cd14984  92 ISIDRYLAIVHAVSALRARTLLHGKLTCLGVWALALLLSLPEFIFSqVSEENGSsicsydyPEDTATTWKTLLRLLQNIL 171
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*.
gi 21758308 170 --CCPLMV-LPCLALILHVECRARRRQRSAKLNhVILAMVSVFLVS 212
Cdd:cd14984 172 gfLLPLLVmLFCYSRIIRTLLRARNHKKHRALR-VIFAVVVVFFLC 216
7tmA_GPR17 cd15161
G protein-coupled receptor 17, member of the class A family of seven-transmembrane G ...
23-131 1.98e-04

G protein-coupled receptor 17, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR17 is a Forkhead box protein O1 (FOXO1) target and abundantly expressed in agouti-related peptide (AGRP) neurons. FOXO1 is a transcription factor that plays key roles in regulation of gluconeogenesis and glycogenolysis by insulin signaling. For instance, food intake and body weight increase when hypothalamic FOXO1 is activated, whereas they both decrease when FOXO1 is inhibited. However, a recent study has been reported that GPR17 deficiency in mice did not affect food intake or glucose homeostasis. Thus, GPR17 may not play a role in the control of food intake, body weight, or glycemic control. GPR17 is phylogenetically closely related to purinergic P2Y and cysteinyl-leukotriene receptors.


Pssm-ID: 320289 [Multi-domain]  Cd Length: 277  Bit Score: 42.39  E-value: 1.98e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21758308  23 NGLVLWFFGFSIK-RNPFSIYFLHLASADVGYLFSKAVFSILNTGGFLGTFADYirsVCRVLGLCMFLT---GVSLLPAV 98
Cdd:cd15161  18 NTLALWLFIHDRKsGTPSNVFLMHLAVADLSYVLILPMRLVYHLSGNHWPFGEV---PCRLAGFLFYLNmyaSLYFLACI 94
                        90       100       110
                ....*....|....*....|....*....|...
gi 21758308  99 SAERCASVIFPAWYWRRRPKRLSAVVCALLWVL 131
Cdd:cd15161  95 SVDRFLAIVHPVKSMKIRKPLYAHVVCGFLWVI 127
7tmA_Prostanoid_R cd14981
G protein-coupled receptors for prostanoids, member of the class A family of ...
77-139 2.23e-04

G protein-coupled receptors for prostanoids, member of the class A family of seven-transmembrane G protein-coupled receptors; Prostanoids are the cyclooxygenase (COX) metabolites of arachidonic acid, which include the prostaglandins (PGD2, PGE2, PGF2alpha), prostacyclin (PGI2), and thromboxane A2 (TxA2). These five major bioactive prostanoids acts as mediators or modulators in a wide range of physiological and pathophysiological processes within the kidney and play important roles in inflammation, platelet aggregation, and vasoconstriction/relaxation, among many others. They act locally by preferentially interacting with G protein-coupled receptors designated DP, EP. FP, IP, and TP, respectively. The phylogenetic tree suggests that the prostanoid receptors can be grouped into two major branches: G(s)-coupled (DP1, EP2, EP4, and IP) and G(i)- (EP3) or G(q)-coupled (EP1, FP, and TP), forming three clusters.


Pssm-ID: 320112 [Multi-domain]  Cd Length: 288  Bit Score: 42.23  E-value: 2.23e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 21758308  77 RSVCRVLGLCMFLTGVS---LLPAVSAERCASVIFPAWYWRRRPKRLSAVVCALLWVLSLLVTCLH 139
Cdd:cd14981  73 QPLCDYFGFMMSFFGLSsllIVCAMAVERFLAITHPFFYNSHVKKRRARLMLGAVWAFALLIASLP 138
7tmA_PAR cd15162
protease-activated receptors, member of the class A family of seven-transmembrane G ...
23-258 5.64e-04

protease-activated receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; This subfamily includes purinergic receptor P2Y8 and protease-activated receptors. P2Y8 (or P2RY8) expression is often increased in leukemia patients, and it plays a role in the pathogenesis of acute leukemia. P2Y8 is phylogenetically closely related to the protease-activated receptors (PARs), which are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. Four different types of the protease-activated receptors have been identified (PAR1-4) and are predominantly expressed in platelets. PAR1, PAR3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 341328 [Multi-domain]  Cd Length: 280  Bit Score: 40.89  E-value: 5.64e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21758308  23 NGLVLWFFGFSIKR-NPFSIYFLHLASADvgyLFSKAVFSILNTGGFLGTFADYIRSVCRVLGL---CMFLTGVSLLPAV 98
Cdd:cd15162  18 NGMALWVLLFRTKKkAPAVIYMANLAIAD---LLLVIWLPFKIAYHIHGNNWIFGEALCRLVTVafyGNMYCSILLLTCI 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21758308  99 SAERCASVIFPAWYWRRRPKRLSAVVCALLWVLSLLVTC-----LHNYFCVFLGR-------GAPGAACRHMDIFLGILL 166
Cdd:cd15162  95 SIDRYLAIVHPMGHRRLRARRYALGTCLAIWLLALLVTLplylvKQTIFLPALDIttchdvlPEQLLVGDWFYYFLSLAI 174
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21758308 167 FLLCCPLMV-LPCLALILHV------ECRARRRQRSAKLNHVILAM-VSVFLVSSIYLGIDWFLFWVFQIPAPFPEYVTD 238
Cdd:cd15162 175 VGFLIPFILtASCYVATIRTlaaledENSEKKKKRAIKLAATVLAIfIICFAPSNLLLLAHYSLISSSGTGHLYFAYLLA 254
                       250       260
                ....*....|....*....|.
gi 21758308 239 LCI-CINSSAKPIVYFLAGRD 258
Cdd:cd15162 255 LCLsTLNSCIDPFIYYFVSKE 275
7tmA_CXCR1_2 cd15178
CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G ...
23-135 5.84e-04

CXC chemokine receptor types 1 and 2, member of the class A family of seven-transmembrane G protein-coupled receptors; CXCR1 and CXCR2 are closely related chemotactic receptors for a group of CXC chemokines distinguished by the presence of the amino acid motif ELR immediately adjacent to their CXC motif. Expression of CXCR1 and CXCR2 is strictly controlled in neutrophils by external stimuli such as lipopolysaccharide (LPS), tumor necrosis factor (TNF)-alpha, Toll-like receptor agonists, and nitric oxide. CXCL8 (formerly known as interleukin-8) binds with high-affinity and activates both receptors. CXCR1 also binds CXCL7 (neutrophil-activating protein-2), whereas CXCR2 non-selectively binds to all seven ELR-positive chemokines (CXCL1-7). Chemokines are principal regulators for leukocyte trafficking, recruitment, and activation. Chemokine family membership is defined on the basis of sequence homology and on the presence of variations on a conserved cysteine motif, which allows the family to further divide into four subfamilies (CC, CXC, XC, and CX3C). Chemokines interact with seven-transmembrane receptors which are typically coupled to G protein for signaling. Currently, there are ten known receptors for CC chemokines, seven for CXC chemokines, and single receptors for the XC and CX3C chemokines.


Pssm-ID: 341333 [Multi-domain]  Cd Length: 279  Bit Score: 40.72  E-value: 5.84e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21758308  23 NGLVLWFFGFS-IKRNPFSIYFLHLASADVGYLFSKAVFSILNTGGFL-GTFAdyirsvCRVLGLCM---FLTGVSLLPA 97
Cdd:cd15178  18 NSLVVLVILYNrRSRSSTDVYLLHLAIADLLFALTLPFWAVSVVKGWIfGTFM------CKLVSLLQeanFYSGILLLAC 91
                        90       100       110
                ....*....|....*....|....*....|....*...
gi 21758308  98 VSAERCAsVIFPAWYWRRRPKRLSAVVCALLWVLSLLV 135
Cdd:cd15178  92 ISVDRYL-AIVHATRALTQKRHLVKFVCAGVWLLSLLL 128
7tmA_BK-1 cd15380
bradykinin receptor B1, member of the class A family of seven-transmembrane G protein-coupled ...
23-257 6.04e-04

bradykinin receptor B1, member of the class A family of seven-transmembrane G protein-coupled receptors; The bradykinin receptor family is a group of the seven transmembrane G-protein coupled receptors, whose endogenous ligand is the pro-inflammatory nonapeptide bradykinin that mediates various vascular and pain responses. Two major bradykinin receptor subtypes, B1 and B2, have been identified based on their pharmacological properties. The B1 receptor is rapidly induced by tissue injury and inflammation, whereas the B2 receptor is ubiquitously expressed on many tissue types. Both receptors contain three consensus sites for N-linked glycosylation in extracellular domains and couple to G(q) protein to activate phospholipase C, leading to phosphoinositide hydrolysis and intracellular calcium mobilization. They can also interact with G(i) protein to inhibit adenylate cyclase and activate the MAPK (mitogen-activated protein kinase) pathways.


Pssm-ID: 320502 [Multi-domain]  Cd Length: 286  Bit Score: 40.94  E-value: 6.04e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21758308  23 NGLVLWFFGFSIKR-NPFSIYFLHLASADVGYLFSKAVFSILNTGGFLGTF-ADYIRSVCRVLGLCMFlTGVSLLPAVSA 100
Cdd:cd15380  18 NLFVLFVFLLPRRRlTIAEIYLANLAASDLVFVLGLPFWAENIRNQFNWPFgNFLCRVISGVIKANLF-ISIFLVVAISQ 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21758308 101 ERCASVIFPAWYWRRRPKRLSAVVCALLWVLSLLVTclhnyFCVFLGRGAPG------AACR--------HMDIFLGILL 166
Cdd:cd15380  97 DRYRTLVHTMTSRRQRSRRQAQVICLLIWVFGGLLS-----IPTFLFRSVKHvpdlniSACIllfpheawHFARRVELNI 171
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21758308 167 FLLCCPLMVLPCLALILHVECRARRRQ--------RSAKLNHVILAMVSVFLVS----SIYLGIDwFLFWVFQIPAPFPE 234
Cdd:cd15380 172 VGFLLPLAAIVFFNFHIIASLRERTEEsrkrcgglKDTKATRLILTLVLMFLVCwtpyHFFAFLD-FLFQVEVIQGCFWE 250
                       250       260       270
                ....*....|....*....|....*....|
gi 21758308 235 YVTDLCI-------CINSSAKPIVYFLAGR 257
Cdd:cd15380 251 EFIDLGLqlanffaFANSCLNPVIYVFAGK 280
7tmA_MCHR-like cd15088
melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G ...
7-263 9.77e-04

melanin concentrating hormone receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; Melanin-concentrating hormone receptor (MCHR) binds melanin concentrating hormone and is presumably involved in the neuronal regulation of food intake and energy homeostasis. Despite strong homology with somatostatin receptors, MCHR does not appear to bind somatostatin. Two MCHRs have been characterized in vertebrates, MCHR1 and MCHR2. MCHR1 is expressed in all mammals, whereas MCHR2 is only expressed in the higher order mammals, such as humans, primates, and dogs, and is not found in rodents. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320216 [Multi-domain]  Cd Length: 278  Bit Score: 40.13  E-value: 9.77e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21758308   7 VMNYIFLLLCLCGLVGNGLVLW-FFGFSIKRNPFSIYFLHLASADVGYLFSKAVFSILNTGGFLGTFADYIRSVCRVLGL 85
Cdd:cd15088   2 IMPSVFGCICVVGLVGNGIVLYvLVRCSKLRTAPDIFIFNLAVADLLFMLGMPFLIHQFAIDGQWYFGEVMCKIITALDA 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21758308  86 CMFLTGVSLLPAVSAERCASVIFPAWYWRRRPKRLSAVVCALLWVLS-LLVTCLHNYFCVFLGR-GAPGAACRHMD---- 159
Cdd:cd15088  82 NNQFTSTYILTAMSVDRYLAVVHPIRSTKYRTRFVAKLVNVGLWAASfLSILPVWVYSSLIYFPdGTTFCYVSLPSpddl 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21758308 160 --IFLGILLFLLCCPLMV-LPCLALILH------VECRARR-RQRSAKLNHVILAMVSVFLVSsiylgidWFLFWVFQIP 229
Cdd:cd15088 162 ywFTIYHFILGFAVPLVViTVCYILILHrlargvAPGNQSHgSSRTKRVTKMVILIVVVFIVC-------WLPFHVVQLV 234
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....
gi 21758308 230 APFPEYVT-------DLCICI---NSSAKPIVYFLAGRDKSQRL 263
Cdd:cd15088 235 NLAMNRPTlafevayFLSICLgyaNSCLNPFVYILVSENFRKRL 278
7tmA_KiSS1R cd15095
KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of ...
42-257 2.84e-03

KiSS1-derived peptide (kisspeptin) receptor, member of the class A family of seven-transmembrane G protein-coupled receptors; The G protein-coupled KiSS1-derived peptide receptor (GPR54 or kisspeptin receptor) binds the peptide hormone kisspeptin (previously known as metastin), which encoded by the metastasis suppressor gene (KISS1) expressed in various endocrine and reproductive tissues. The KiSS1 receptor is coupled to G proteins of the G(q/11) family, which lead to activation of phospholipase C and increase of intracellular calcium. This signaling cascade plays an important role in reproduction by regulating the secretion of gonadotropin-releasing hormone.


Pssm-ID: 320223 [Multi-domain]  Cd Length: 288  Bit Score: 38.80  E-value: 2.84e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21758308  42 YFLHLASADVGYLFSKAVFSILNT-------GGFLGTFADYIRSVCrVLGLCMFLTgvsllpAVSAERCASVIFPAWYWR 114
Cdd:cd15095  38 YIVNLAVTDLAFLVCCVPFTAALYatpswvfGDFMCKFVNYMMQVT-VQATCLTLT------ALSVDRYYAIVHPIRSLR 110
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21758308 115 RRPKRLSAVVCALLWVLSLLVTC--LHNYFCVFLGRGAPGAACRHM---DIFLGILLFLLCCPLMVLP------CLALIL 183
Cdd:cd15095 111 FRTPRVAVVVSACIWIVSFLLSIpvAIYYRLEEGYWYGPQTYCREVwpsKAFQKAYMIYTVLLTYVIPlaiiavCYGLIL 190
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21758308 184 ------------HVECRARRRQR-SAKLNHVILAMVSVFLVSsiylgidWF------LFWVFQIPAPFPE---YVTDLCI 241
Cdd:cd15095 191 rrlwrrsvdgnnQSEQLSERALRqKRKVTRMVIVVVVLFAIC-------WLpnhvlnLWQRFDPNFPETYatyALKIAAL 263
                       250
                ....*....|....*....
gi 21758308 242 CI---NSSAKPIVYFLAGR 257
Cdd:cd15095 264 CLsyaNSAVNPFVYAFMGE 282
7tmA_P2Y6_P2Y3-like cd15968
P2Y purinoceptors 6 and 3, and similar proteins, member of the class A family of ...
23-137 3.01e-03

P2Y purinoceptors 6 and 3, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes P2Y receptor 6 (P2Y6), P2Y3, and P2Y3-like proteins. These receptors belong to the G(i) class of a family of purinergic G-protein coupled receptors. In the CNS, P2Y6 plays a role in microglia activation and phagocytosis, and is involved in the secretion of interleukin from monocytes and macrophages in the immune system. The P2Y receptor family is composed of eight subtypes, which are activated by naturally occurring extracellular nucleotides such as ATP, ADP, UTP, UDP, and UDP-glucose. These eight receptors are ubiquitous in human tissues and can be further classified into two subfamilies based on sequence homology and second messenger coupling: a subfamily of five P2Y1-like receptors (P2Y1, P2Y2, P2Y4, P2Y6, and P2Y11Rs) that are coupled to G(q) protein to activate phospholipase C (PLC) and a second subfamily of three P2Y12-like receptors (P2Y12, P2YR13, and P2Y14Rs) that are coupled to G(i) protein to inhibit adenylate cyclase. Several cloned subtypes, such as P2Y3, P2Y5, and P2Y7-10, are not functional mammalian nucleotide receptors. The native agonists for P2Y receptors are: ATP (P2Y2, P2Y12), ADP (P2Y1, P2Y12, and P2Y13), UTP (P2Y2, P2Y4), UDP (P2Y6, P2Y14), and UDP-glucose (P2Y14).


Pssm-ID: 320634 [Multi-domain]  Cd Length: 285  Bit Score: 38.60  E-value: 3.01e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21758308  23 NGLVLWFFGFSIKR-NPFSIYFLHLASADVGYLFSKAVFSILNTGGFLGTFADYIRSVCRVLGLCMFLTGVSLLPAVSAE 101
Cdd:cd15968  18 NSVVLTRCCRHTKAwTRTAIYMVNLALADLLYALSLPLLIYNYAMRDRWLFGDFMCRLVRFLFYFNLYGSILFLTCISVH 97
                        90       100       110
                ....*....|....*....|....*....|....*.
gi 21758308 102 RCASVIFPAWYWRRRPKRLSAVVCALLWVLSLLVTC 137
Cdd:cd15968  98 RYLGICHPMRPWHKETRRAAWLTCVLVWILVFAQTL 133
7tmA_PAR4 cd15372
protease-activated receptor 4, member of the class A family of seven-transmembrane G ...
23-136 3.08e-03

protease-activated receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; Protease-acted receptors (PARs) are seven-transmembrane proteins that belong to the class A G-protein coupled receptor (GPCR) family. Four different types of the protease-activated receptors have been identified: PAR1, PAR2, PAR3, and PAR4. PARs are predominantly expressed in platelets and are activated by serine proteases such as thrombin, trypsin, and tryptase. These proteases cleave the extracellular domain of the receptor to form a new N-terminus, which in turn functions as a tethered ligand. The newly-formed tethered ligand binds intramolecularly to activate the receptor and triggers G-protein binding and intracellular signaling. PAR1, PA3, and PAR4 are activated by thrombin, whereas PAR2 is activated by trypsin. The PARs are known to couple with several G-proteins including Gi (cAMP inhibitory), G12/13 (Rho and Ras activation), and Gq (calcium signaling) to activate downstream signaling messengers which induces numerous cellular and physiological effects.


Pssm-ID: 320494 [Multi-domain]  Cd Length: 274  Bit Score: 38.58  E-value: 3.08e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21758308  23 NGLVLWFFGFSIKRNPFSIYFLHLASADVgYLFSKAVFSILNTggFLGTFADYIRSVCRVlgLCMFLTG-----VSLLPA 97
Cdd:cd15372  18 NGLALWVLATQVKRLPSTIFLINLAVADL-LLILVLPFKISYH--FLGNNWPFGEGLCRV--VTAFFYGnmycsVLLLMC 92
                        90       100       110
                ....*....|....*....|....*....|....*....
gi 21758308  98 VSAERCASVIFPAWYWRRRPKRLSAVVCALLWVLSLLVT 136
Cdd:cd15372  93 ISLDRYLAVVHPFFARTLRSRRFALCMCTAIWLIAAALT 131
7tmA_GPR182 cd14988
G protein-coupled receptor 182, member of the class A family of seven-transmembrane G ...
23-140 3.39e-03

G protein-coupled receptor 182, member of the class A family of seven-transmembrane G protein-coupled receptors; GPR182 is an orphan G-protein coupled receptor that belongs to the class A of seven-transmembrane GPCR superfamily. When GPR182 gene was first cloned, it was proposed to encode an adrenomedullin receptor. However when the corresponding protein was expressed, it was found not to respond to adrenomedullin (ADM). All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes.


Pssm-ID: 320119 [Multi-domain]  Cd Length: 278  Bit Score: 38.60  E-value: 3.39e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21758308  23 NGLVLWFFGFSIKR-NPFSIYFLHLASADVGYLFSKAVFSILNT-------GGFLGTFADYIRSVcrvlglcMFLTGVSL 94
Cdd:cd14988  18 NVLVIWVNWHRWGSkNLVNLYILNMAIADLGVVLTLPVWMLEVMldytwlwGSFLCKFTHYFYFA-------NMYSSIFF 90
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*.
gi 21758308  95 LPAVSAERCASVIFPAWYWRRRPKRLSAVVCALLWVLSLLVTCLHN 140
Cdd:cd14988  91 LTCLSVDRYLTLTSSSPFWQQHQHRIRRALCAGIWVLSAIIPLPEV 136
7tmA_FFAR2_FFAR3 cd15170
free fatty acid receptors 2, 3, and similar proteins, member of the class A family of ...
79-132 7.54e-03

free fatty acid receptors 2, 3, and similar proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This subgroup includes free fatty acid receptor 2 (FFAR2), FFAR3, and similar proteins. They are a member of the class A G-protein coupled receptors that bind free fatty acids. The FFAR subfamily is composed of three receptors, each encoded by a separate gene (FFAR1, FFAR2, and FFAR3). These genes and a fourth pseudogene, GPR42, are localized together on chromosome 19. FFAR2 and FFAR3 are cell-surface receptors for short chain FFAs (SCFAs) with different ligand affinities, whereas FFAR1 is a receptor for medium- and long-chain FFAs. FFAR2 activation by SCFA suppresses adipose insulin signaling, which leads to inhibition of fat accumulation in adipose tissue. FAAR3 is expressed in intestinal L cells, which produces glucagon-like peptide 1 (GLP-1) and peptide YY (PYY), thus suggesting that this receptor may be involved in energy homeostasis. FFARs are considered important components of the body's nutrient sensing mechanism, and therefore, these receptors are potential therapeutic targets for the treatment of metabolic disorders, such as type 2 diabetes and obesity.


Pssm-ID: 320298  Cd Length: 278  Bit Score: 37.24  E-value: 7.54e-03
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 21758308  79 VCRVLGLCMFLT---GVSLLPAVSAERCASVIFPAWYWRRRPKRLSAVVCALLWVLS 132
Cdd:cd15170  73 LCPLSSFIFFSTiyiSTLFLTAISVERYLGVAFPIKYKLRRRPLYAVIASVFFWVLA 129
7tmA_LPAR4 cd15155
lysophosphatidic acid receptor 4, member of the class A family of seven-transmembrane G ...
23-133 7.55e-03

lysophosphatidic acid receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors; Lysophosphatidic acid receptor 4 (LPAR4) is a G protein-coupled receptor that binds and is activated by the bioactive lipid lysophosphatidic acid (LPA), which is released by activated platelets and constitutively found in serum. Phylogenetic analysis of the class A GPCRs shows that LAPR4 is classified into the cluster consisting receptors that are preferentially activated by adenosine and uridine nucleotides. Although LPA6 (P2Y5) is expressed in human hair follicle cells, LPA4 and LPA5 are not. These three receptors are highly homologous and mediate an increase in intracellular cAMP production. Activation of LPAR5 is coupled to G(12/13) proteins, leading to neurite retraction and stress fiber formation, whereas coupling to G(q) protein leads to increases in calcium levels.


Pssm-ID: 320283 [Multi-domain]  Cd Length: 283  Bit Score: 37.21  E-value: 7.55e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21758308  23 NGLVLWFFGFSIK-RNPFSIYFLHLASADVGYLFSKAvFSILNTGGFLGTFADyirSVCRVLGLCmFLTGVS----LLPA 97
Cdd:cd15155  18 NCASLFVFCFRMKmRNETAIFMTNLAVSDLLFVFTLP-FKIFYNFNRHWPFGD---SLCKISGTA-FLTNIYgsmlFLTC 92
                        90       100       110
                ....*....|....*....|....*....|....*.
gi 21758308  98 VSAERCASVIFPAWYWRRRPKRLSAVVCALLWVLSL 133
Cdd:cd15155  93 ISVDRFLAIVYPFRSRTIRTRRNSAIVCAGVWILVL 128
7tmA_SSTR4 cd15973
somatostatin receptor type 4, member of the class A family of seven-transmembrane G ...
7-252 9.56e-03

somatostatin receptor type 4, member of the class A family of seven-transmembrane G protein-coupled receptors; G protein-coupled somatostatin receptors (SSTRs) are composed of five distinct subtypes (SSTR1-5) that display strong sequence similarity with opioid receptors. All five receptor subtypes bind the natural somatostatin (somatotropin release inhibiting factor), a polypeptide hormone that regulates a wide variety of physiological functions such as neurotransmission, cell proliferation, contractility of smooth muscle cells, and endocrine signaling as well as inhibition of the release of many secondary hormones. SSTR4 plays a critical role in mediating inflammation. Unlike other SSTRs, SSTR4 subtype is not detected in all pituitary adenomas while it is expressed in the normal human pituitary.


Pssm-ID: 320639 [Multi-domain]  Cd Length: 274  Bit Score: 37.14  E-value: 9.56e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21758308   7 VMNYIFLLLCLCGLVGNGLVLW-FFGFSIKRNPFSIYFLHLASADVGYLFSKAVFSILNTGGFLGTFADYIRSVCRVLGL 85
Cdd:cd15973   2 VIQFIYALVCLVGLIGNSMVIFvILRYAKMKTATNIYILNLAIADELFMLSVPFLAASAALQHWPFGSAMCRTVLSVDGI 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21758308  86 CMFlTGVSLLPAVSAERCASVIFPAWYWRRRPKRLSAVVCALLWVLSLLVTCLHNYFCVFLGRGAPGAACRHMDIFLGIL 165
Cdd:cd15973  82 NMF-TSVFCLTVLSVDRYIAVVHPLRAARYRRPTVAKMINICVWILSLLVISPIIIFADTATRKGQAVACNLIWPHPAWS 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21758308 166 LFLLCCPLMV---LPCLA-----LILHVECRA--------RRRQRSAKLNHVILAMVSVFLVSsiylgidWFLFWVFQIP 229
Cdd:cd15973 161 AAFVIYTFLLgflLPVLAiglcyILIIGKMRAvalkagwqQRRKSEKKITRMVLMVVTVFVIC-------WMPFYVVQLL 233
                       250       260       270
                ....*....|....*....|....*....|
gi 21758308 230 APF----PEYVTDLCICI---NSSAKPIVY 252
Cdd:cd15973 234 NLFlprlDATVNHASLILsyaNSCANPILY 263
7tmA_LTB4R cd14975
leukotriene B4 receptors, member of the class A family of seven-transmembrane G ...
23-134 9.94e-03

leukotriene B4 receptors, member of the class A family of seven-transmembrane G protein-coupled receptors; Leukotriene B4 (LTB4), a metabolite of arachidonic acid, is a powerful chemotactic activator for granulocytes and macrophages. Two receptors for LTB4 have been identified: a high-affinity receptor (LTB4R1 or BLT1) and a low-affinity receptor (TB4R2 or BLT2). Both BLT1 and BLT2 receptors belong to the rhodopsin-like G-protein coupled receptor superfamily and primarily couple to G(i) proteins, which lead to chemotaxis, calcium mobilization, and inhibition of adenylate cyclase. In some cells, they can also couple to the G(q)-like protein, G16, and activate phospholipase C. LTB4 is involved in mediating inflammatory processes, immune responses, and host defense against infection. Studies have shown that LTB4 stimulates leukocyte extravasation, neutrophil degranulation, lysozyme release, and reactive oxygen species generation.


Pssm-ID: 320106 [Multi-domain]  Cd Length: 278  Bit Score: 37.08  E-value: 9.94e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 21758308  23 NGLVLWFFGFSIK-RNPFSIYFLHLASADVGYLFSKAVF--SILNTGGFLGTFAdyIRSVCRVLGLCMFlTGVSLLPAVS 99
Cdd:cd14975  18 NSFVIWSILIKVKqRSVTMLLVLNLALADLAVLLTLPVWiyFLATGTWDFGLAA--CKGCVYVCAVSMY-ASVFLITLMS 94
                        90       100       110
                ....*....|....*....|....*....|....*
gi 21758308 100 AERCASVIFPAWYWRRRPKRLSAVVCALLWVLSLL 134
Cdd:cd14975  95 LERFLAVSRPFVSQGWRAKALAHKVLAIIWLLAVL 129
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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