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Conserved domains on  [gi|22760904|dbj|BAC11376|]
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unnamed protein product [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GHB_like super family cl21545
Glycoprotein hormone beta chain homologues; This family of cystine-knot hormones includes the ...
 82-158 1.95e-08

Glycoprotein hormone beta chain homologues; This family of cystine-knot hormones includes the beta chains of gonadotropins, thyrotropins, follitropins, choriogonadotropins and more. The members are reproductive hormones that consist of two glycosylated chains (alpha and beta), which form a tightly bound dimer.


The actual alignment was detected with superfamily member smart00041:

Pssm-ID: 473907  Cd Length: 82  Bit Score: 48.94  E-value: 1.95e-08
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 22760904     82 IRKQDCMSqSPINVASCDGKCPSATIYNINIESHlrFCKCCRENGVRNLSVPLYCSgNGTEIMYTLQEPIDCTCQWN 158
Cdd:smart00041   8 ITYNGCTS-VTVKNAFCEGKCGSASSYSIQDVQH--SCSCCQPHKTKTRQVRLRCP-DGSTVKKTVMHIEECGCEPN 80
 
Name Accession Description Interval E-value
CT smart00041
C-terminal cystine knot-like domain (CTCK); The structures of transforming growth factor-beta ...
 82-158 1.95e-08

C-terminal cystine knot-like domain (CTCK); The structures of transforming growth factor-beta (TGFbeta), nerve growth factor (NGF), platelet-derived growth factor (PDGF) and gonadotropin all form 2 highly twisted antiparallel pairs of beta-strands and contain three disulphide bonds. The domain is non-globular and little is conserved among these presumed homologues except for their cysteine residues. CT domains are predicted to form homodimers.


Pssm-ID: 214482  Cd Length: 82  Bit Score: 48.94  E-value: 1.95e-08
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 22760904     82 IRKQDCMSqSPINVASCDGKCPSATIYNINIESHlrFCKCCRENGVRNLSVPLYCSgNGTEIMYTLQEPIDCTCQWN 158
Cdd:smart00041   8 ITYNGCTS-VTVKNAFCEGKCGSASSYSIQDVQH--SCSCCQPHKTKTRQVRLRCP-DGSTVKKTVMHIEECGCEPN 80
 
Name Accession Description Interval E-value
CT smart00041
C-terminal cystine knot-like domain (CTCK); The structures of transforming growth factor-beta ...
 82-158 1.95e-08

C-terminal cystine knot-like domain (CTCK); The structures of transforming growth factor-beta (TGFbeta), nerve growth factor (NGF), platelet-derived growth factor (PDGF) and gonadotropin all form 2 highly twisted antiparallel pairs of beta-strands and contain three disulphide bonds. The domain is non-globular and little is conserved among these presumed homologues except for their cysteine residues. CT domains are predicted to form homodimers.


Pssm-ID: 214482  Cd Length: 82  Bit Score: 48.94  E-value: 1.95e-08
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 22760904     82 IRKQDCMSqSPINVASCDGKCPSATIYNINIESHlrFCKCCRENGVRNLSVPLYCSgNGTEIMYTLQEPIDCTCQWN 158
Cdd:smart00041   8 ITYNGCTS-VTVKNAFCEGKCGSASSYSIQDVQH--SCSCCQPHKTKTRQVRLRCP-DGSTVKKTVMHIEECGCEPN 80
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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