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Conserved domains on  [gi|22761388|dbj|BAC11565|]
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unnamed protein product [Homo sapiens]

Protein Classification

triose-phosphate transporter family protein( domain architecture ID 706146)

triose-phosphate transporter family protein belongs to the RhaT/DMT (drug/metabolite transporter) superfamily

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TPT super family cl26744
Triose-phosphate Transporter family; This family includes transporters with a specificity for ...
 1-146 4.49e-46

Triose-phosphate Transporter family; This family includes transporters with a specificity for triose phosphate.


The actual alignment was detected with superfamily member pfam03151:

Pssm-ID: 474852 [Multi-domain]  Cd Length: 290  Bit Score: 154.37  E-value: 4.49e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22761388     1 MWGLVSALAATLCFSLQNIFSKKVLRD-SRIHHLRLLNILGCHAVFFMIPTWVLVDLSAFLVSSDLTYVYQWPWTLLLLA 79
Cdd:pfam03151 144 WIGFISAMISNLGFSLRNIFSKKLMKGkDNLDNLNLFAIITILSLLLLLPVWLLVEGFKKFPSLLQSGKVGLKDVYMLLL 223

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 22761388    80 VSGFCNFAQNVIAFSILNLVSPLSYSVANATKRIMVITVSLIMLRNPVTSTIVLGMMTAILGVFLYN 146
Cdd:pfam03151 224 LSGVCFHLYNQVAYMILERVSPVTHSVANTVKRVVVIVSSILVFGNPVSPLNAIGTAIAIAGVFLYS 290
 
Name Accession Description Interval E-value
TPT pfam03151
Triose-phosphate Transporter family; This family includes transporters with a specificity for ...
 1-146 4.49e-46

Triose-phosphate Transporter family; This family includes transporters with a specificity for triose phosphate.


Pssm-ID: 308657 [Multi-domain]  Cd Length: 290  Bit Score: 154.37  E-value: 4.49e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22761388     1 MWGLVSALAATLCFSLQNIFSKKVLRD-SRIHHLRLLNILGCHAVFFMIPTWVLVDLSAFLVSSDLTYVYQWPWTLLLLA 79
Cdd:pfam03151 144 WIGFISAMISNLGFSLRNIFSKKLMKGkDNLDNLNLFAIITILSLLLLLPVWLLVEGFKKFPSLLQSGKVGLKDVYMLLL 223

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 22761388    80 VSGFCNFAQNVIAFSILNLVSPLSYSVANATKRIMVITVSLIMLRNPVTSTIVLGMMTAILGVFLYN 146
Cdd:pfam03151 224 LSGVCFHLYNQVAYMILERVSPVTHSVANTVKRVVVIVSSILVFGNPVSPLNAIGTAIAIAGVFLYS 290
tpt TIGR00817
Tpt phosphate/phosphoenolpyruvate translocator; The 6-8 TMS Triose-phosphate Transporter (TPT) ...
 3-149 1.67e-20

Tpt phosphate/phosphoenolpyruvate translocator; The 6-8 TMS Triose-phosphate Transporter (TPT) Family (TC 2.A.7.9)Functionally characterized members of the TPT family are derived from the inner envelope membranes of chloroplasts and nongreen plastids of plants. However,homologues are also present in yeast. Saccharomyces cerevisiae has three functionally uncharacterized TPT paralogues encoded within its genome. Under normal physiologicalconditions, chloroplast TPTs mediate a strict antiport of substrates, frequently exchanging an organic three carbon compound phosphate ester for inorganic phosphate (Pi).Normally, a triose-phosphate, 3-phosphoglycerate, or another phosphorylated C3 compound made in the chloroplast during photosynthesis, exits the organelle into thecytoplasm of the plant cell in exchange for Pi. However, experiments with reconstituted translocator in artificial membranes indicate that transport can also occur by achannel-like uniport mechanism with up to 10-fold higher transport rates. Channel opening may be induced by a membrane potential of large magnitude and/or by high substrateconcentrations. Nongreen plastid and chloroplast carriers, such as those from maize endosperm and root membranes, mediate transport of C3 compounds phosphorylated atcarbon atom 2, particularly phosphenolpyruvate, in exchange for Pi. These are the phosphoenolpyruvate:Pi antiporters (PPT). Glucose-6-P has also been shown to be asubstrate of some plastid translocators (GPT). The three types of proteins (TPT, PPT and GPT) are divergent in sequence as well as substrate specificity, but their substratespecificities overlap. [Hypothetical proteins, Conserved]


Pssm-ID: 129898 [Multi-domain]  Cd Length: 302  Bit Score: 87.47  E-value: 1.67e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22761388     3 GLVSALAATLCFSLQNIFSKKVLRDSRIHHLRLLNILGCHAVFFMIPTWVLVDLSAFL---------VSSDLTYvyqwpW 73
Cdd:TIGR00817 146 GFLSAMISNITFVSRNIFSKKAMTIKSLDKTNLYAYISIMSLFLLSPPAFITEGPPFLphgfmqaisGVNVTKI-----Y 220

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 22761388    74 TLLLLAVSGFCNFAQNViAFSILNLVSPLSYSVANATKRIMVITVSLIMLRNPVTSTIVLGMMTAILGVFLYNKTK 149
Cdd:TIGR00817 221 TVSLVAAMGFFHFYQQV-AFMLLGRVSPLTHSVGNCMKRVVVIVVSILFFGTKISPQQVFGTGIAIAGVFLYSRVK 295
PTZ00343 PTZ00343
triose or hexose phosphate/phosphate translocator; Provisional
 2-149 1.07e-12

triose or hexose phosphate/phosphate translocator; Provisional


Pssm-ID: 240371 [Multi-domain]  Cd Length: 350  Bit Score: 65.91  E-value: 1.07e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22761388    2 WGLVSALAATLCFSLQNIFSKKVLRDSRI--HHLRLLNIlgchavfFMIPTWVLVDLSAFLVSsdLTYVYQW-------- 71
Cdd:PTZ00343 194 LAFWCAMLSNLGSSLRSIFAKKTMKNKSEigENLTASNI-------YMLLTLIASLISLPLVL--FFEGKKWvpvwtnyt 264

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22761388   72 ----PWT----LLLLAVSGFCNFAQNVIAFSILNLVSPLSYSVANATKRIMVITVSLIMLRNPVTSTIVLGMMTAILGVF 143
Cdd:PTZ00343 265 anmtNYTkgiiIFKIFFSGVWYYLYNEVAFYCLGKVNQVTHAVANTLKRVVIIVSSIIIFQTQVTLLGYLGMAVAILGAL 344


                 ....*.
gi 22761388  144 LYNKTK 149
Cdd:PTZ00343 345 LYSLFK 350
RhaT COG0697
Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and ...
 1-144 2.64e-03

Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism, Amino acid transport and metabolism, General function prediction only];


Pssm-ID: 440461 [Multi-domain]  Cd Length: 290  Bit Score: 37.90  E-value: 2.64e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22761388   1 MWGLVSALAATLCFSLQNIFSKKVLRdsrihHLRLLNILGCHAVFFMIPTWVLVDLSAFLVSSDLTyvyQWPWTLLL-LA 79
Cdd:COG0697 148 LLGDLLALLAALSWALYTVLTRRLSR-----RLDPLTLTFWQMLVGALLLLPLALLTGLPLPLSAA---AWLALLYLgLF 219

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 22761388  80 VSGFCNFAQNvIAFSILN--LVSPLSYSVAnatkrIMVITVSLIMLRNPVTSTIVLGMMTAILGVFL 144
Cdd:COG0697 220 GTALAYLLWF-RALRRLGasRAAPLTYLEP-----VFAVLLGWLLLGEPLTPLQLLGAALILAGVLL 280
 
Name Accession Description Interval E-value
TPT pfam03151
Triose-phosphate Transporter family; This family includes transporters with a specificity for ...
 1-146 4.49e-46

Triose-phosphate Transporter family; This family includes transporters with a specificity for triose phosphate.


Pssm-ID: 308657 [Multi-domain]  Cd Length: 290  Bit Score: 154.37  E-value: 4.49e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22761388     1 MWGLVSALAATLCFSLQNIFSKKVLRD-SRIHHLRLLNILGCHAVFFMIPTWVLVDLSAFLVSSDLTYVYQWPWTLLLLA 79
Cdd:pfam03151 144 WIGFISAMISNLGFSLRNIFSKKLMKGkDNLDNLNLFAIITILSLLLLLPVWLLVEGFKKFPSLLQSGKVGLKDVYMLLL 223

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 22761388    80 VSGFCNFAQNVIAFSILNLVSPLSYSVANATKRIMVITVSLIMLRNPVTSTIVLGMMTAILGVFLYN 146
Cdd:pfam03151 224 LSGVCFHLYNQVAYMILERVSPVTHSVANTVKRVVVIVSSILVFGNPVSPLNAIGTAIAIAGVFLYS 290
tpt TIGR00817
Tpt phosphate/phosphoenolpyruvate translocator; The 6-8 TMS Triose-phosphate Transporter (TPT) ...
 3-149 1.67e-20

Tpt phosphate/phosphoenolpyruvate translocator; The 6-8 TMS Triose-phosphate Transporter (TPT) Family (TC 2.A.7.9)Functionally characterized members of the TPT family are derived from the inner envelope membranes of chloroplasts and nongreen plastids of plants. However,homologues are also present in yeast. Saccharomyces cerevisiae has three functionally uncharacterized TPT paralogues encoded within its genome. Under normal physiologicalconditions, chloroplast TPTs mediate a strict antiport of substrates, frequently exchanging an organic three carbon compound phosphate ester for inorganic phosphate (Pi).Normally, a triose-phosphate, 3-phosphoglycerate, or another phosphorylated C3 compound made in the chloroplast during photosynthesis, exits the organelle into thecytoplasm of the plant cell in exchange for Pi. However, experiments with reconstituted translocator in artificial membranes indicate that transport can also occur by achannel-like uniport mechanism with up to 10-fold higher transport rates. Channel opening may be induced by a membrane potential of large magnitude and/or by high substrateconcentrations. Nongreen plastid and chloroplast carriers, such as those from maize endosperm and root membranes, mediate transport of C3 compounds phosphorylated atcarbon atom 2, particularly phosphenolpyruvate, in exchange for Pi. These are the phosphoenolpyruvate:Pi antiporters (PPT). Glucose-6-P has also been shown to be asubstrate of some plastid translocators (GPT). The three types of proteins (TPT, PPT and GPT) are divergent in sequence as well as substrate specificity, but their substratespecificities overlap. [Hypothetical proteins, Conserved]


Pssm-ID: 129898 [Multi-domain]  Cd Length: 302  Bit Score: 87.47  E-value: 1.67e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22761388     3 GLVSALAATLCFSLQNIFSKKVLRDSRIHHLRLLNILGCHAVFFMIPTWVLVDLSAFL---------VSSDLTYvyqwpW 73
Cdd:TIGR00817 146 GFLSAMISNITFVSRNIFSKKAMTIKSLDKTNLYAYISIMSLFLLSPPAFITEGPPFLphgfmqaisGVNVTKI-----Y 220

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 22761388    74 TLLLLAVSGFCNFAQNViAFSILNLVSPLSYSVANATKRIMVITVSLIMLRNPVTSTIVLGMMTAILGVFLYNKTK 149
Cdd:TIGR00817 221 TVSLVAAMGFFHFYQQV-AFMLLGRVSPLTHSVGNCMKRVVVIVVSILFFGTKISPQQVFGTGIAIAGVFLYSRVK 295
PTZ00343 PTZ00343
triose or hexose phosphate/phosphate translocator; Provisional
 2-149 1.07e-12

triose or hexose phosphate/phosphate translocator; Provisional


Pssm-ID: 240371 [Multi-domain]  Cd Length: 350  Bit Score: 65.91  E-value: 1.07e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22761388    2 WGLVSALAATLCFSLQNIFSKKVLRDSRI--HHLRLLNIlgchavfFMIPTWVLVDLSAFLVSsdLTYVYQW-------- 71
Cdd:PTZ00343 194 LAFWCAMLSNLGSSLRSIFAKKTMKNKSEigENLTASNI-------YMLLTLIASLISLPLVL--FFEGKKWvpvwtnyt 264

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22761388   72 ----PWT----LLLLAVSGFCNFAQNVIAFSILNLVSPLSYSVANATKRIMVITVSLIMLRNPVTSTIVLGMMTAILGVF 143
Cdd:PTZ00343 265 anmtNYTkgiiIFKIFFSGVWYYLYNEVAFYCLGKVNQVTHAVANTLKRVVIIVSSIIIFQTQVTLLGYLGMAVAILGAL 344


                 ....*.
gi 22761388  144 LYNKTK 149
Cdd:PTZ00343 345 LYSLFK 350
EamA pfam00892
EamA-like transporter family; This family includes many hypothetical membrane proteins of ...
 1-144 8.00e-05

EamA-like transporter family; This family includes many hypothetical membrane proteins of unknown function. Many of the proteins contain two copies of the aligned region. The family used to be known as DUF6. Members of this family usually carry 5+5 transmembrane domains, and this domain attempts to model five of these.


Pssm-ID: 307170  Cd Length: 136  Bit Score: 41.03  E-value: 8.00e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22761388     1 MWGLVSALAATLCFSLQNIFSKKVLRdsRIHHLRLLnilgchAVFFMIPTWVLVDLSAFLVSSDLTYVYQWPWTLLLLAV 80
Cdd:pfam00892   1 LKGILLALLAALIWAIYFVFSKILLR--RISPLTLT------FWRFLIAGILLLPFALFTGGKLVIPLKSWLALLYLGVL 72

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 22761388    81 SGFCNFaqnVIAFSILNLVSPLSYSVANATKRIMVITVSLIMLRNPVTSTIVLGMMTAILGVFL 144
Cdd:pfam00892  73 GTFLGF---LLYFYGLKYVSASNASVITSLSPVFTLILSVLLLGEKLTLKQLLGIVLILLGVLL 133
nst TIGR00803
UDP-galactose transporter; The 10-12 TMS Nucleotide Sugar Transporters (TC 2.A.7.10) ...
 3-145 6.15e-04

UDP-galactose transporter; The 10-12 TMS Nucleotide Sugar Transporters (TC 2.A.7.10)Nucleotide-sugar transporters (NSTs) are found in the Golgi apparatus and the endoplasmic reticulum of eukaryotic cells. Members of the family have been sequenced from yeast, protozoans and animals. Animals such as C. elegans possess many of these transporters. Humans have at least two closely related isoforms of the UDP-galactose:UMP exchange transporter.NSTs generally appear to function by antiport mechanisms, exchanging a nucleotide-sugar for a nucleotide. Thus, CMP-sialic acid is exchanged for CMP; GDP-mannose is preferentially exchanged for GMP, and UDP-galactose and UDP-N-acetylglucosamine are exchanged for UMP (or possibly UDP). Other nucleotide sugars (e.g., GDP-fucose, UDP-xylose, UDP-glucose, UDP-N-acetylgalactosamine, etc.) may also be transported in exchange for various nucleotides, but their transporters have not been molecularly characterized. Each compound appears to be translocated by its own transport protein. Transport allows the compound, synthesized in the cytoplasm, to be exported to the lumen of the Golgi apparatus or the endoplasmic reticulum where it is used for the synthesis of glycoproteins and glycolipids.


Pssm-ID: 129885  Cd Length: 222  Bit Score: 39.65  E-value: 6.15e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22761388     3 GLVSALAATLCFSLQNIFSKKVLRDSR----IHHLRLlnilgchAVFFMIPTWVLVDLSAFLVSSDLTYVYQWPWTL--- 75
Cdd:TIGR00803  86 GLSAVLSALLSSGFAGVYFEKILKDGDtmfwSRNLQL-------PLFGLFSTFSVLLWSDGTLISNFGFFIGYPTAVwiv 158

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 22761388    76 -LLLAVSGFCNFAQNVIAFSILnlvsplsYSVANATKRIMVITVSLIMLRNPVTSTIVLGMMTAILGVFLY 145
Cdd:TIGR00803 159 gLLNVGGGLCIGGVVRYADNTT-------KSFVTALSIILSTLASVRLFDAKISSTFYLGAILVFLATFLY 222
RhaT COG0697
Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and ...
 1-144 2.64e-03

Permease of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism, Amino acid transport and metabolism, General function prediction only];


Pssm-ID: 440461 [Multi-domain]  Cd Length: 290  Bit Score: 37.90  E-value: 2.64e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 22761388   1 MWGLVSALAATLCFSLQNIFSKKVLRdsrihHLRLLNILGCHAVFFMIPTWVLVDLSAFLVSSDLTyvyQWPWTLLL-LA 79
Cdd:COG0697 148 LLGDLLALLAALSWALYTVLTRRLSR-----RLDPLTLTFWQMLVGALLLLPLALLTGLPLPLSAA---AWLALLYLgLF 219

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 22761388  80 VSGFCNFAQNvIAFSILN--LVSPLSYSVAnatkrIMVITVSLIMLRNPVTSTIVLGMMTAILGVFL 144
Cdd:COG0697 220 GTALAYLLWF-RALRRLGasRAAPLTYLEP-----VFAVLLGWLLLGEPLTPLQLLGAALILAGVLL 280
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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