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Conserved domains on  [gi|26351773|dbj|BAC39523|]
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unnamed protein product [Mus musculus]

Protein Classification

glycosyltransferase family 29 protein( domain architecture ID 690)

glycosyltransferase family 29 protein catalyzes the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds; uses a nucleotide monophosphosugar as the donor (CMP-NeuA) instead of a nucleotide diphosphosugar

CATH:  3.90.1480.20
CAZY:  GT29
EC:  2.4.99.-
Gene Ontology:  GO:0008373|GO:0006486
PubMed:  9334165

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
GT29 super family cl45931
glycosyltransferase family 29; Glycosyltransferase family 29 members (also called ...
 73-300 1.31e-166

glycosyltransferase family 29; Glycosyltransferase family 29 members (also called sialyltransferases) are enzymes that transfer sialic acid to oligosaccharide, each having specificity for a certain sugar substrate.


The actual alignment was detected with superfamily member cd23977:

Pssm-ID: 480271  Cd Length: 228  Bit Score: 461.64  E-value: 1.31e-166
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26351773  73 CHSCAVVSSSGQMLGSGLGAQIDGAECVLRMNQAPTVGFEEDVGQRSTLRVISHTSVPLLLRNYSHYFQHARDTLYVVWG 152
Cdd:cd23977   1 CRRCAVVSSSGQMLGSGLGPEIDQQECVLRMNVAPTAGYEADVGNRSSLRVVSHTSVPLLLRNQGYFFQQSRDTKYVIWG 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26351773 153 QGRHMDRVLGGRTYRTLLQLTRMYPGLQVYTFTERMMAYCDQIFQDETGKNRRQSGSFLSTGWFTMILALELCEEIVVYG 232
Cdd:cd23977  81 PERNMDRDGGGKTYRALLTLAKMYPHLQVYTLTEEKMAYCDGVFQNETGKNRMKSGSFLSTGWFTMILALELCEEILVYG 160

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 26351773 233 MVSDSYCSEKSPRSVPYHYFEKGRLDECQMYRLHEQAPRSAHRFITEKAVFSRWAKKRPIVFAHPSWR 300
Cdd:cd23977 161 MVSDSYCRNKNHSSVPYHYYEKGRLDECRMYLVHERAPRGGHRFITEKAIFSRWAKRKKIRFAHPSWT 228
 
Name Accession Description Interval E-value
GT29_ST6GALNAC4 cd23977
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are ...
 73-300 1.31e-166

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467705  Cd Length: 228  Bit Score: 461.64  E-value: 1.31e-166
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26351773  73 CHSCAVVSSSGQMLGSGLGAQIDGAECVLRMNQAPTVGFEEDVGQRSTLRVISHTSVPLLLRNYSHYFQHARDTLYVVWG 152
Cdd:cd23977   1 CRRCAVVSSSGQMLGSGLGPEIDQQECVLRMNVAPTAGYEADVGNRSSLRVVSHTSVPLLLRNQGYFFQQSRDTKYVIWG 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26351773 153 QGRHMDRVLGGRTYRTLLQLTRMYPGLQVYTFTERMMAYCDQIFQDETGKNRRQSGSFLSTGWFTMILALELCEEIVVYG 232
Cdd:cd23977  81 PERNMDRDGGGKTYRALLTLAKMYPHLQVYTLTEEKMAYCDGVFQNETGKNRMKSGSFLSTGWFTMILALELCEEILVYG 160

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 26351773 233 MVSDSYCSEKSPRSVPYHYFEKGRLDECQMYRLHEQAPRSAHRFITEKAVFSRWAKKRPIVFAHPSWR 300
Cdd:cd23977 161 MVSDSYCRNKNHSSVPYHYYEKGRLDECRMYLVHERAPRGGHRFITEKAIFSRWAKRKKIRFAHPSWT 228
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 59-289 6.58e-30

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 113.86  E-value: 6.58e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26351773    59 YSSVPDGKPLIRELCHSCAVVSSSGQMLGSGLGAQIDGAECVLRMNQAPTVGFEEDVGQRSTLRVISHTSVPLLLRNYSH 138
Cdd:pfam00777  29 LELLPKVSPFDNKRCRRCAVVGNGGILRGSGCGKEIDSHDFVIRCNLAPTKGYEKDVGSKTTLRTMNPESAIDSKYGNLG 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26351773   139 YFQ-HARDTLYV---------VW----GQGRHMDRVLggRTYRTLLQLTRMYPGLQVYTFTERMMAYCDQIFQDETGKN- 203
Cdd:pfam00777 109 FSHpRDPFVEFVlvpfkgrdlLWlpafLTKGNVSRSL--RVLYTLKEVKIPVDPDKVLFLHPDFLRYVANFWLRSHGLKg 186

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26351773   204 RRqsgsfLSTGWFTMILALELCEEIVVYGmvsdsYCSEKSPRSVPYHYFEKGRldecqMYRLHEQAPrsaHRFITEKAVF 283
Cdd:pfam00777 187 RR-----PSTGLLMLSLALHLCDEVSLYG-----FGPFLDSRGNSHHYYDNVL-----MKKGGFYGV---HDMPFEFKLL 248


                  ....*.
gi 26351773   284 SRWAKK 289
Cdd:pfam00777 249 QKLHKE 254
 
Name Accession Description Interval E-value
GT29_ST6GALNAC4 cd23977
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are ...
 73-300 1.31e-166

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467705  Cd Length: 228  Bit Score: 461.64  E-value: 1.31e-166
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26351773  73 CHSCAVVSSSGQMLGSGLGAQIDGAECVLRMNQAPTVGFEEDVGQRSTLRVISHTSVPLLLRNYSHYFQHARDTLYVVWG 152
Cdd:cd23977   1 CRRCAVVSSSGQMLGSGLGPEIDQQECVLRMNVAPTAGYEADVGNRSSLRVVSHTSVPLLLRNQGYFFQQSRDTKYVIWG 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26351773 153 QGRHMDRVLGGRTYRTLLQLTRMYPGLQVYTFTERMMAYCDQIFQDETGKNRRQSGSFLSTGWFTMILALELCEEIVVYG 232
Cdd:cd23977  81 PERNMDRDGGGKTYRALLTLAKMYPHLQVYTLTEEKMAYCDGVFQNETGKNRMKSGSFLSTGWFTMILALELCEEILVYG 160

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 26351773 233 MVSDSYCSEKSPRSVPYHYFEKGRLDECQMYRLHEQAPRSAHRFITEKAVFSRWAKKRPIVFAHPSWR 300
Cdd:cd23977 161 MVSDSYCRNKNHSSVPYHYYEKGRLDECRMYLVHERAPRGGHRFITEKAIFSRWAKRKKIRFAHPSWT 228
GT29_ST6GALNAC3_4_5_6 cd23965
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family ...
 73-297 1.66e-131

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, bytransfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substratespecificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467693  Cd Length: 225  Bit Score: 372.35  E-value: 1.66e-131
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26351773  73 CHSCAVVSSSGQMLGSGLGAQIDGAECVLRMNQAPTVGFEEDVGQRSTLRVISHTSVPLLLRN-YSHYFQHARDTLYVVW 151
Cdd:cd23965   1 CDTCALVSSSGQLLGSGAGKEIDSADCVIRMNDAPTRGYEKDVGRRTTIRVVSHSSLPRLLRNaILLLAGTRAPTVVVFW 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26351773 152 GQGRHMDRVLGGRtYRTLLQLTRMYPGLQVYTFTERMMAYCDQIFQDETGKNRRQSGSFLSTGWFTMILALELCEEIVVY 231
Cdd:cd23965  81 GPETKMNKDGAGK-YNLLRSLSKKYPDVEFYSLTPEKMDYADELFEKETGKSRIKSGTWLSTGWFTMLLALDVCDEIKVY 159

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 26351773 232 GMVSDSYCSEKSPRSVPYHYFEKGRLDECQMYRLHEQAPRSAHRFITEKAVFSRWAKKRPIVFAHP 297
Cdd:cd23965 160 GMVPENYCREHPNSKVPYHYYEPGGLKECTYYNYHENALKGGHRFITEKAVFARWAKKYNITFHHP 225
GT29_ST6GALNAC3 cd23975
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are ...
 73-299 8.37e-111

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467703  Cd Length: 226  Bit Score: 320.34  E-value: 8.37e-111
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26351773  73 CHSCAVVSSSGQMLGSGLGAQIDGAECVLRMNQAPTVGFEEDVGQRSTLRVISHTSVPLLLRNYSHYFQHARDTLYVVWG 152
Cdd:cd23975   1 CDLCAVVSNSGQMVGQKVGAEIDQSSCIWRMNNAPTKGYEEDVGKRTTIRVVSHTSVPLLLKNPDYFFKETNETIYVIWG 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26351773 153 QGRHMDRVLGGRTYRTLLQLTRMYPGLQVYTFTERMMAYCDQIFQDETGKNRRQSGSFLSTGWFTMILALELCEEIVVYG 232
Cdd:cd23975  81 PFRNMRKDGKGIVYNMLKKAVESYPQAKIYVTTEKRMSYCDTVFKKETGKDRVQSGSYLSTGWFTLILAMDACYGIHVYG 160

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 26351773 233 MVSDSYCSEKSPRSVPYHYFEKGRlDECQMYRLHEQAPRSAHRFITEKAVFSRWAKKRPIVFAHPSW 299
Cdd:cd23975 161 MINDTYCKTEGYRKVPYHYYEPGR-DECDEYFLHENAPYGGHRFITEKKVFAKWAKKHPITFTHPNW 226
GT29_ST6GALNAC5 cd23976
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are ...
 58-300 1.26e-88

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilize Sia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467704  Cd Length: 244  Bit Score: 264.42  E-value: 1.26e-88
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26351773  58 GYSSVPDGKPLiRELCHSCAVVSSSGQMLGSGLGAQIDGAECVLRMNQAPTVGFEEDVGQRSTLRVISHTSVPLLLRNYS 137
Cdd:cd23976   1 GYISIIDHKPL-KMHCKSCALVTSSGHLTGSNRGNEIDETECVIRMNDAPTRGYGKDVGNKTSLRVIAHSSIQRILRNRN 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26351773 138 HYFQHARDTLYVVWGQGRHMDRVLGGRTYRTLLQLTRMYPGLQVYTFTERMMAYCDQIFQDETGKNRRQSGSFLSTGWFT 217
Cdd:cd23976  80 ELLNVSQGTVFIFWGPSNYMRRDGKGLVYNNLQLMNQILPKLKVYTITRHKMLQFDELFKRETGKDRKISNTWLSTGWFT 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26351773 218 MILALELCEEIVVYGMVSDSYCSEKSPRSVPYHYFEKGRLDECQMYRLHEQAPR-SAHRFITEKAVFSRWAKKRPIVFAH 296
Cdd:cd23976 160 MIIALELCDRINVYGMVPPDFCRDPNHPSVPYHYYEPSGPDECTMYISHERGRKgSHHRFITEKRVFANWARTFNIHFYQ 239


                ....
gi 26351773 297 PSWR 300
Cdd:cd23976 240 PDWK 243
GT29_ST6GALNAC6 cd23978
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are ...
 73-299 1.87e-87

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467706  Cd Length: 229  Bit Score: 260.94  E-value: 1.87e-87
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26351773  73 CHSCAVVSSSGQMLGSGLGAQIDGAECVLRMNQAPTVGFEEDVGQRSTLRVISHTSVPLLLRNYSHYFQHARDTLYVVWG 152
Cdd:cd23978   1 CHQCALITSSSHLLGTSLGPEIDQTECTIRMNDAPTTGYEKDVGNKTTLRVVAHSSVYRVLRRPQEFLNRTPETTLIFWG 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26351773 153 QGRHMDRVLGGRTYRTLLQLTRMYPGLQVYTFTERMMAYCDQIFQDETGKNRRQSGSFLSTGWFTMILALELCEEIVVYG 232
Cdd:cd23978  81 PPNKMQKDGKSNLFRIIQRASMTFPNMSAFVVSPRRMRQFDDLFRGETGRDRKKSHSWLSTGWFTMVIAVELCDNVHVYG 160

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 26351773 233 MVSDSYCSEK-SPRSVPYHYFEKGRLDECQMYRLHEQAPR-SAHRFITEKAVFSRWAKKRPIVFAHPSW 299
Cdd:cd23978 161 MVPPNYCSKRpTPKKMPYHYYEPKGPDECVTYIQNEHGRRgNHHRFITEKRVFARWAEHYNITFSHPSW 229
GT29 cd19952
glycosyltransferase family 29; Glycosyltransferase family 29 members (also called ...
 76-286 2.11e-44

glycosyltransferase family 29; Glycosyltransferase family 29 members (also called sialyltransferases) are enzymes that transfer sialic acid to oligosaccharide, each having specificity for a certain sugar substrate.


Pssm-ID: 467690  Cd Length: 193  Bit Score: 149.82  E-value: 2.11e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26351773  76 CAVVSSSGQMLGSGLGAQIDGAECVLRMNQAPTVGFEEDVGQRSTLRVISHTSVPLLLRNYSHYFQH---ARDTLYVVWG 152
Cdd:cd19952   1 CAVVGNSGILLGSEYGKEIDSHDAVFRFNQAPTKGFEKDVGSKTTFRVLNSKWAGFYLRGPRCGCHPlplEEEVVLILSR 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26351773 153 QGRHMdrvlggrtYRTLLQLTRMYPGLQVY--TFTERMMAYCDQIFQDETGKNrRQSGSFLSTGWFTMILALELCEEIVV 230
Cdd:cd19952  81 AAAAD--------FKRLKRRKKRHDNAVLLltDPAPDLLSYVRKRLEKLGLKS-FFGGNAPSSGLLAVLLALQLCDSVDL 151

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 26351773 231 YGMVSDSYCSekspRSVPYHYFEKGRldecqmyrlhEQAPRSAHRFITEKAVFSRW 286
Cdd:cd19952 152 YGFGVDSGHA----PKVPYHYYDLVE----------AEEGTAVHSFDLEAELLRAL 193
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 59-289 6.58e-30

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 113.86  E-value: 6.58e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26351773    59 YSSVPDGKPLIRELCHSCAVVSSSGQMLGSGLGAQIDGAECVLRMNQAPTVGFEEDVGQRSTLRVISHTSVPLLLRNYSH 138
Cdd:pfam00777  29 LELLPKVSPFDNKRCRRCAVVGNGGILRGSGCGKEIDSHDFVIRCNLAPTKGYEKDVGSKTTLRTMNPESAIDSKYGNLG 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26351773   139 YFQ-HARDTLYV---------VW----GQGRHMDRVLggRTYRTLLQLTRMYPGLQVYTFTERMMAYCDQIFQDETGKN- 203
Cdd:pfam00777 109 FSHpRDPFVEFVlvpfkgrdlLWlpafLTKGNVSRSL--RVLYTLKEVKIPVDPDKVLFLHPDFLRYVANFWLRSHGLKg 186

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26351773   204 RRqsgsfLSTGWFTMILALELCEEIVVYGmvsdsYCSEKSPRSVPYHYFEKGRldecqMYRLHEQAPrsaHRFITEKAVF 283
Cdd:pfam00777 187 RR-----PSTGLLMLSLALHLCDEVSLYG-----FGPFLDSRGNSHHYYDNVL-----MKKGGFYGV---HDMPFEFKLL 248


                  ....*.
gi 26351773   284 SRWAKK 289
Cdd:pfam00777 249 QKLHKE 254
GT29_ST6GAL1_2 cd23968
beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are ...
 44-266 3.09e-24

beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are beta-galactosidealpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the terminal galactose residue of a glycochain, by transfering sialic acid fromCMP-Sia. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467696  Cd Length: 266  Bit Score: 98.88  E-value: 3.09e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26351773  44 AAPRSTVPGPLHFSGYSSVPDGKPLIRELCH-----SCAVVSSSGQMLGSGLGAQIDGAECVLRMNQAPTVGFEEDVGQR 118
Cdd:cd23968  11 AAPFSTLRKTTSPFKDLLSLRYPFPESSLENtkrynTCAVVSSSGALLGSKLGKEIDSHDAVLRFNDAPTKGFEKDVGSK 90

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26351773 119 STLRVISHTsvpLLLRNYSHYFQ--HARDTLYVVWGQGRHmDRVLGGRTYRT-------LLQLTRMYPGLQVYTFTERMM 189
Cdd:cd23968  91 TTLRLINSQ---ILSKPEFNFLTdpLYRNVTLLVWDPSSY-NVNLEKWYKKPdfdffpnYIKYRRRHPEEPFYLIDPRFL 166

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 26351773 190 AYCDQIFQDETgKNRRQSGSfLSTGWFTMILALELCEEIVVYGMVSDsycSEKSPRSvpyHYFEKGRLDECQMYRLH 266
Cdd:cd23968 167 WRLWDILQEYT-PEKIKPNP-PSSGFIGIVLMLHLCDWVDVYEYVPS---VRQTDRC---HYYDVEKDLACTLGAWH 235
GT29_ST8SIA cd23963
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are ...
 75-279 9.75e-24

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on their catalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467691  Cd Length: 274  Bit Score: 97.72  E-value: 9.75e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26351773  75 SCAVVSSSGQMLGSGLGAQIDGAECVLRMNQAPTVGFEEDVGQRSTLrvishTSV-PLLLRNYSHYFQHARDTL------ 147
Cdd:cd23963  65 TCAVVGNSGILLGSGCGKEIDSHDFVIRCNLPPIKGFEKDVGRKTNL-----TTLnPSILKRRYNSLKKNRDRDkflnrl 139

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26351773 148 -----YVVW----GQGRHMDRVlggrtyRTLLQLTRMYPGLQVytftermMAYCDQIFQDETGK--NRRQSGSFLSTGWF 216
Cdd:cd23963 140 keyngSILWypkfSFKSSTNLL------LKAARALKKNGLNLT-------VVYSNPEHFLAVQKfwKRRGLEKRPSTGLY 206

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 26351773 217 TMILALELCEEIVVYGMvsdsYCSEKSP--RSVPYHYFEKGRLDEcqmyrlheqaPRSAHRFITE 279
Cdd:cd23963 207 LVSLALTFCDEIHLYGF----WPFPTDPngRPVPYHYYDDLSPST----------KNKVHNMPEE 257
GT29_ST3GAL2 cd23979
beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from ...
 73-256 3.73e-20

beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL2 preferentially utilizes the Galbeta1,3GalNAc on glycolipids as an acceptor substrate. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467707  Cd Length: 279  Bit Score: 88.00  E-value: 3.73e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26351773  73 CHSCAVVSSSGQMLGSGLGAQIDGAECVLRMNQAPTVGFEEDVGQRSTLRVISHTSVPLLLRNYSHYFQHARdTLYVVW- 151
Cdd:cd23979  80 CRRCAVVGNSGNLRGSGYGKDIDGHDFIMRMNQAPTVGFEADVGSRTTHHFMYPESAKNLPANVSFVLVPFK-TLDLLWi 158

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26351773 152 ------GQGRHmdrvlggrTYRTLLQLTRMYpglqvytfTERMMAYCDQIFQDETGKNRRQSGSFLSTGWFTMILALELC 225
Cdd:cd23979 159 tsalstGQIRF--------TYAPVKQFLRVD--------KDKVQIYNPAFFKYIHDRWTEHHGRYPSTGMLVLFFALHVC 222

                       170       180       190
                ....*....|....*....|....*....|.
gi 26351773 226 EEIVVYGMVSDSycsekspRSVPYHYFEKGR 256
Cdd:cd23979 223 DEVNVYGFGADS-------RGNWHHYWENNR 246
GT29_ST8SIA3_oligo cd23970
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2, ...
 59-270 6.25e-20

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3 synthesizes polysialic acid and has been shown to autopolysialylate. ST8Sia3 utilizes the Siaalpha2,3Galbeta1,4GlcNAc structure on N-glycans of glycoproteins and glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acidand the terminal sialic acid residues of glycochains, by transfering sialic acidfrom CMP-Sia and they belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467698  Cd Length: 284  Bit Score: 87.45  E-value: 6.25e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26351773  59 YSSVPDGKPLIRELCHSCAVVSSSGQMLGSGLGAQIDGAECVLRMNQAPTVGFEEDVGQRSTLRvishTSVPLLLRNYSH 138
Cdd:cd23970  54 RSLLPEVSPFQNKHYNTCAVVGNSGILTNSQCGNEIDKSDFVFRCNFAPTEGFEKDVGRKTNLT----TFNPSILEKYYN 129

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26351773 139 YFQHARDTL-----------YVVW--GQGRHMDRVlggrTYRTLLQLTrmypgLQVYTFTERMMAYCDQIFQDETG--KN 203
Cdd:cd23970 130 NLLTIQDRNnfflslkkldgAILWipAFFFHTSAT----VTRTLVDFF-----VEHRGQLKVQLAWPGNIMQHVNRywKT 200

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 26351773 204 RRQSGSFLSTGWFTMILALELCEEIVVYGMVsdSYCSEKSPRSVPYHYFEKGRLDECQMYRLHEQAP 270
Cdd:cd23970 201 KHLSPKRLSTGILMYTLASAICEEIHLYGFW--PFGFDPTGTPLPYHYYDKKGTKFTTKWQESHQLP 265
GT29_ST6GAL2 cd23986
beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside ...
 39-231 1.06e-19

beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside alpha-2,3-sialyltransferases that catalyze an alpha2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by a transfering sialic acid from CMP-Sia. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467714  Cd Length: 270  Bit Score: 86.43  E-value: 1.06e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26351773  39 DRHLPAAPRSTvpgpLHFSGYSSvpdgkplirelchsCAVVSSSGQMLGSGLGAQIDGAECVLRMNQAPTVGFEEDVGQR 118
Cdd:cd23986  33 EKYVPKIPLSK----LHLRGFRS--------------CAVVTSAGAILNSSLGKEIDSHDAVLRFNSAPTRGYEKDVGNK 94

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26351773 119 STLRVISHTsvplLLRNYSHYFQHA---RDTLYVVWGQGRHMDRVLGG------RTYRTLLQLTRMYPGLQVYTFTERMM 189
Cdd:cd23986  95 TTIRIINSQ----ILTNPNHHFIDSslyKDVILVAWDPAPYSANLHKWykkpdyNLFTPYVQYRKRNPNQPFYILHPKFI 170

                       170       180       190       200
                ....*....|....*....|....*....|....*....|..
gi 26351773 190 AYCDQIFQDETGKNRRQSGSflSTGWFTMILALELCEEIVVY 231
Cdd:cd23986 171 WQLWDIIQENTQEKIQPNPP--SSGFIGILIMMSMCREVHVY 210
GT29_ST3GAL1_2 cd23966
beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from ...
 50-256 5.01e-19

beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL1 and 2 preferentially utilize the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1O-glycans) and on glycolipids as an acceptor substrate, respectively. Members ofthis family belong to glycosyltransferase family 29.


Pssm-ID: 467694  Cd Length: 276  Bit Score: 84.64  E-value: 5.01e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26351773  50 VPGPLHFSgySSVPDGkplirelCHSCAVVSSSGQMLGSGLGAQIDGAECVLRMNQAPTVGFEEDVGQRSTLRVISHTSV 129
Cdd:cd23966  63 VPGENPYR--TRDPNR-------CRRCAVVGNSGNLRGSRYGKLIDSHDFVIRMNKAPTKGFEKDVGSKTTHHFMYPESA 133

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26351773 130 pLLLRNYSHY----FQhardTLYVVW-------GQGRhmdrvlggRTY---RTLLQLTRmyPGLQVY--TFtermMAY-C 192
Cdd:cd23966 134 -VDLDPGVHLvlvpFK----VLDLQWlisalttGEIT--------RTYtpvKRFIKADK--DKVLVInpAF----IKYvH 194

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 26351773 193 DQIFQDEtgknrrqsGSFLSTGWFTMILALELCEEIVVYGMVSDSYCSEksprsvpYHYFEKGR 256
Cdd:cd23966 195 DNWTEHH--------GRYPSTGFLALIFALHICDEVSVFGFGADSKGNW-------HHYWEKNR 243
GT29_ST3GAL3_4_5_6 cd23967
beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid ...
 73-266 3.49e-18

beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL3 and 4 utilize bothGalbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates. ST3GAL5 is also known as GM3 ganglioside synthase. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467695  Cd Length: 205  Bit Score: 80.80  E-value: 3.49e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26351773  73 CHSCAVVSSSGQMLGSGLGAQIDGAECVLRMNQAPTVGFEEDVGQRSTLRVISHTSVPLLLRNYShyfqhaRDTLYVV-- 150
Cdd:cd23967   2 CRRCVVVGNGGVLKGKSLGSVIDKYDVVIRMNDAPVKGYEKDVGSKTTFRMFYPESAFRDPEEYD------SDWLLVLvp 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26351773 151 -------WgqgrhMDRVLGGRTYRTLL----QLTRMYPgLQVYTF----------TERMMAYcdQIFQDETGKNRRqsgs 209
Cdd:cd23967  76 fksmdllW-----LQAVIKGKKPNGKGgfwkKIATSVP-KPPKKIrilnpyilqeAAFDLIG--LPMNGKQGKNVP---- 143

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 26351773 210 flSTGWFTMILALELCEEIVVYGMVSDSycsekSPRSVPYHYFEKGRLDECQMYRLH 266
Cdd:cd23967 144 --TTGIIAIVMALHYCDEVDIAGFGYDP-----SDPNAPLHYYDSLTMKAIKRSWTH 193
GT29_ST6GALNAC1 cd23973
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are ...
 48-254 5.00e-18

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467701  Cd Length: 309  Bit Score: 82.49  E-value: 5.00e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26351773  48 STVPGPLHFSGYSSVPDGKplirELCHSCAVVSSSGQMLGSGLGAQIDGAECVLRMNQAPTVGFEEDVGQRSTLRVISHT 127
Cdd:cd23973  62 ELIPKPKEQQLLALSPPGG----DGCIRCAVVGNGGILNGSKMGQEIDSHDYVFRVNGAVIKGYEEDVGTRTSFYVHTAH 137

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26351773 128 SVPLLLRNYSHY----FQHARDTLYVVWGQGRH----MDRVLGGRTYRTlLQLTRMYPglQVY---TFTERMMAYCDQIF 196
Cdd:cd23973 138 SITSSLMILQKRgfknIPQDKDIKYILFPEGPRdyqwLEALLKNKTIPS-GAYYGRRP--RSYfsgDFTEDKYLVLHPDF 214

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 26351773 197 QDETgKNRRQSGSFL----------STGWFTMILALELCEEIVVYGMVSDSYcsekspRSVPYHYFEK 254
Cdd:cd23973 215 LRYV-KNRFLRSKTLkgkywaiyrpTTGAFLLLTALHLCDTVSAYGFITEDY------RKYPDHYYDK 275
GT29_ST6GAL1 cd23985
beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside ...
 76-231 6.63e-17

beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by transfering sialic acid from CMP-Sia. ST6Gal1 play important roles in the immune system. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467713  Cd Length: 266  Bit Score: 78.60  E-value: 6.63e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26351773  76 CAVVSSSGQMLGSGLGAQIDGAECVLRMNQAPTVGFEEDVGQRSTLRVISHTsvplLLRNYSHYFqhARDTLY-----VV 150
Cdd:cd23985  48 CAVVSSAGSLKSSGLGREIDSHDAVLRFNGAPTAGFQQDVGTKTTIRLINSQ----LVTTEKHKF--LKDSLYnegilIV 121

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26351773 151 WGQGRH---------------MDRVlggRTYRTLlqltrmYPGLQVYTFTERMMAYCDQIFQDETGKNRRQSGSflSTGW 215
Cdd:cd23985 122 WDPAPYhsdipewyknpdynfFENY---KTYRRL------NPNQPFYILHPQMQWELWDIIQENSPEEIQPNPP--SSGM 190

                       170
                ....*....|....*.
gi 26351773 216 FTMILALELCEEIVVY 231
Cdd:cd23985 191 LGIILMMTLCDQVDVY 206
GT29_ST3GAL1 cd23980
beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from ...
 73-237 2.09e-15

beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL1 preferentially utilizes the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1 O-glycans) as an acceptor substrate. Members of this family belong to glycosyltransferase family29 (GT29).


Pssm-ID: 467708  Cd Length: 280  Bit Score: 74.53  E-value: 2.09e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26351773  73 CHSCAVVSSSGQMLGSGLGAQIDGAECVLRMNQAPTVGFEEDVGQRSTLRVISHTSVPLLLRNYSHYFQHARdTLYVVWg 152
Cdd:cd23980  81 CRRCAVVGNSGNLKESYYGPQIDSHDFVLRMNKAPTEGFEADVGSKTTHHFVYPESFRELAQNVSMILVPFK-TLDLEW- 158

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26351773 153 qgrHMDRVLGGRTYRTLLQLTRmypglQVYTFTERMMAYCDQIFQDETGKNRRQSGSFLSTGWFTMILALELCEEIVVYG 232
Cdd:cd23980 159 ---VISATTTGTISHTYVPVPR-----KIKVKKEKILIYHPAFIKYVFDRWLQGHGRYPSTGILSVIFSLHVCDEVDLYG 230


                ....*
gi 26351773 233 MVSDS 237
Cdd:cd23980 231 FGADS 235
GT29_ST8SIA4 cd23988
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase ...
 59-289 2.92e-14

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia4 catalyzes longer polysialicacid formation of NCAMs than ST8Sia2. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467716  Cd Length: 278  Bit Score: 71.52  E-value: 2.92e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26351773  59 YSSVPDGKPLIRELCHSCAVVSSSGQMLGSGLGAQIDGAECVLRMNQAPTVGFEEDVGQRSTLRVISHTSVPLL---LRN 135
Cdd:cd23988  50 HSLLPEVSPMKNRRFKTCAVVGNSGILLDSGCGKEIDSHDFVIRCNLAPVVEFAADVGTKSDFITMNPSVVQRAfggFRN 129

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26351773 136 YS------HYFQHARDTL-----YVVWGQGRHMDRVlGGRTYRTLLQLTRMYPGLQV------YTFTERMmaycdQIfqd 198
Cdd:cd23988 130 ESdrekfvHRLSMLNDSVlwipaFMVKGGEKHVEWV-NALILKNKLKVRTAYPSLRLihavrgYWLTNKV-----NI--- 200

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26351773 199 etgknRRQsgsflSTGWFTMILALELCEEIVVYGMVsdSYCSEKSPRSVPYHYFEKGRldecqmYRLHEQAprSAHR--- 275
Cdd:cd23988 201 -----KRP-----STGLLMYTLATRFCDEIHLYGFW--PFPKDANGNPVKYHYYDDLK------YRYFSNA--GPHRmpl 260

                       250
                ....*....|....*
gi 26351773 276 -FITEKAVFSRWAKK 289
Cdd:cd23988 261 eFKTLNVLHNRGALK 275
GT29_ST8SIA_poly cd23969
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be ...
 59-256 8.92e-14

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be polysialyltransferases, and they can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467697  Cd Length: 276  Bit Score: 70.14  E-value: 8.92e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26351773  59 YSSVPDGKPLIRELCHSCAVVSSSGQMLGSGLGAQIDGAECVLRMNQAPTVGFEEDVGQRSTLRvishTSVPLLLRNYSH 138
Cdd:cd23969  50 YQLLPEVSPLKGKHFRTCAVVGNSGILLNSGCGQEIDSHDFVIRCNLAPVEGYEKDVGTKSNLT----TMNPSVIPHAYG 125

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26351773 139 YFQHARDTLYVVWGQGRHMDRVL--------GGRTY---------RTLLQLTRMYPGLQVYTFTERMMAycdqifQDETG 201
Cdd:cd23969 126 DLVNATDKEKFVERLRQLGDSILwipafvskGGEEHvqwtneiilKHKLNVKTAYPPLRLNHAIRGYWL------TTKFR 199

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*
gi 26351773 202 KNRRQSGSFLSTgwftmiLALELCEEIVVYGMVsdSYCSEKSPRSVPYHYFEKGR 256
Cdd:cd23969 200 IKRPSTGLLMYT------LATRFCDEIHLYGFY--PFSEDGNGRAVKYHYYDNRK 246
GT29_ST6GALNAC1_2 cd23964
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members ...
 73-285 2.24e-13

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 and 2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467692  Cd Length: 292  Bit Score: 68.82  E-value: 2.24e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26351773  73 CHSCAVVSSSGQMLGSGLGAQIDGAECVLRMNQAPTVGFEEDVGQRSTLRVisHTSVPLLLRNYSHYFQ----------- 141
Cdd:cd23964  82 CIRCAVVGNGGILNGSGKGKEIDAHDYVFRVNHALTKGFEKDVGTKTSFYT--FFPESLHNSLLKHVPQdkdtkylfipf 159

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26351773 142 HARDTLYVV-WGQGRHMDRVL--GGRTYRTL---LQLTRM---YPGLQVYTFTERMmaycdqifqdetgknRRQSGSFLS 212
Cdd:cd23964 160 KIRDYDYLDaVLSGKPVPDGCdkGKRPPPLFgpkLNATNVrllHPDFIRYLFNRWL---------------NSSTSYRPT 224

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 26351773 213 TGWFTMILALELCEEIVVYGMVSDsycseksPRSvPYHYFEKGRLDECQMYrlheqaprSAHRFITEKAVFSR 285
Cdd:cd23964 225 TGALMLLTALHTCDQVSVYGFGYD-------PRF-SLHYYDKTFVKFTVFY--------ANHDFTNERKLWRK 281
GT29_ST3GAL4 cd23982
beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from ...
 73-122 6.62e-13

beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL4 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,4GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467710  Cd Length: 204  Bit Score: 66.23  E-value: 6.62e-13
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|
gi 26351773  73 CHSCAVVSSSGQMLGSGLGAQIDGAECVLRMNQAPTVGFEEDVGQRSTLR 122
Cdd:cd23982   2 CRRCVVVGNGHNLKNSSLGDVIDSYDVVIRLNDAPVRGFEKDVGSKTTIR 51
GT29_ST3GAL5 cd23983
beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from ...
 73-149 1.91e-12

beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL5 is also known as GM3 ganglioside synthase. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467711  Cd Length: 211  Bit Score: 65.14  E-value: 1.91e-12
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 26351773  73 CHSCAVVSSSGQMLGSGLGAQIDGAECVLRMNQAPTVGFEEDVGQRSTLRVISHTSVPLLLRNYSHyfqharDTLYV 149
Cdd:cd23983   2 CRRCVVVGSGGILHGLELGHLLDQFDIVIRLNNAPVQGYSQDVGNKTTIRMTYPEGAPKSEQEYDP------TSLFV 72
GT29_ST3GAL6 cd23984
beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from ...
 73-122 2.11e-10

beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467712  Cd Length: 206  Bit Score: 59.37  E-value: 2.11e-10
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|
gi 26351773  73 CHSCAVVSSSGQMLGSGLGAQIDGAECVLRMNQAPTVGFEEDVGQRSTLR 122
Cdd:cd23984   2 CKKCVVVGNGGVLRNKSLGKKIDSYDVIIRMNNGPVIGYENDVGKRTTFR 51
GT29_ST8SIA_mono cd23971
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are ...
 59-252 3.47e-10

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on theircatalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467699  Cd Length: 271  Bit Score: 59.58  E-value: 3.47e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26351773  59 YSSVPDGKPLIRELCHSCAVVSSSGQMLGSGLGAQIDGAECVLRMNQAPtVGFEEDVGQRSTLRVIShtsvPLLLRNYSH 138
Cdd:cd23971  50 FSMLPKESPFSNKPLKTCAVVGNGGILKNSSCGREIDSADFVIRCNLPP-LNDSKDVGSKTNLVTAN----PSILREKFH 124

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26351773 139 YFQHARDTLY---VVWGQG--------RHMDRVLGGRTYRTLLQLTRMYpglQVYTFTERMMAYCDQIFQDETGKNRRqs 207
Cdd:cd23971 125 NLKKRRRPFVermKVYGNAllllpafsYTSNTEPSLRALYTLEDFGSPQ---KVLFFNPEYLRNLSRYWKSKGLKARR-- 199

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*
gi 26351773 208 gsfLSTGWFTMILALELCEEIVVYGMVSDSYCSEKSPrsVPYHYF 252
Cdd:cd23971 200 ---LSTGLMLVSAALELCENVHLYGFWPFSTDLDGNP--ISHHYY 239
GT29_ST3GAL3 cd23981
beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from ...
 73-152 1.71e-09

beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL3 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,3GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467709  Cd Length: 207  Bit Score: 56.47  E-value: 1.71e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26351773  73 CHSCAVVSSSGQMLGSGLGAQIDGAECVLRMNQAPTVGFEEDVGQRSTLRVISHTSVPLLLRNYShyfqhaRDTLYVVWG 152
Cdd:cd23981   2 CRRCIIVGNGGVLANKSLGSKIDDYDVVVRLNSAPVKGFEKDVGSKTTLRITYPEGAIQKPEQYE------KDSLFVLAG 75
GT29_ST8SIA1 cd23989
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2, ...
 59-253 2.70e-09

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1 (also known as ganglioside GD3 synthase) adds sialic acids to GM3 ganglioside. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze analpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467717  Cd Length: 272  Bit Score: 56.76  E-value: 2.70e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26351773  59 YSSVPDGKPLIRELcHSCAVVSSSGQMLGSGLGAQIDGAECVLRMNQAP-TVGFEEDVGQRSTLRvishTSVPLLLRNys 137
Cdd:cd23989  50 YSLFPQDTPLQLPL-KKCSVVGNGGILKNSGCGQQIDRADFVMRCNLPPlSREYTDDVGTKTQLV----TANPSIIDK-- 122

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26351773 138 hYFQHardtlyVVWGQGRHMDRV-LGGRTYRTLLQL---TRMYPGLQVY-----TFTERMMAYCDQIFQDETG---KNRR 205
Cdd:cd23989 123 -RFQN------LLWSRKSFVESMkVYGRSYIYMPAFsmkTGTDPSLRVYytladVGANQTVLFANPNFLRNVGkfwKSKG 195

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*...
gi 26351773 206 QSGSFLSTGWFTMILALELCEEIVVYGMVSDSYCSEKspRSVPYHYFE 253
Cdd:cd23989 196 VHAKRLSTGLFLVSAALGLCEEVTIYGFWPFSVDLDE--RTISHHYYD 241
GT29_ST6GALNAC2L cd23974
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are ...
 73-136 4.90e-09

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467702  Cd Length: 309  Bit Score: 56.30  E-value: 4.90e-09
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 26351773  73 CHSCAVVSSSGQMLGSGLGAQIDGAECVLRMNQAPTVGFEEDVGQRSTLRVISHTSVPLLLRNY 136
Cdd:cd23974  84 CIRCAVVGNGGILNGSRMGAEIDGHDYVFRVNGAITKGFEKDVGRRTSFYTFSTNTLMNSLRAY 147
GT29_ST8SIA6 cd23991
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2, ...
 63-253 1.91e-08

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6 (also known as alpha-2,8-sialyltransferase 8F) prefers O-glycans to N-glycans or glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29(GT29).


Pssm-ID: 467719  Cd Length: 273  Bit Score: 54.37  E-value: 1.91e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26351773  63 PDGKPLIRELCHSCAVVSSSGQMLGSGLGAQIDGAECVLRMNQAPTVG-FEEDVGQRSTL-----RVISHTSVPL----- 131
Cdd:cd23991  54 PKSQPFRGYPYKQCAVVGNGGILKNSSCGAEIDQADFVFRCNLPPTGGnISKDVGSKTNLvtanpSIISIKYAKLnerrk 133

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26351773 132 -LLRNYSHY---------FQHARDTlyvvwgqgrhmdrVLGGRTYRTLLQLTRMypgLQVYTFTERMMAYCDQIFQDETG 201
Cdd:cd23991 134 pFLETVSVYgdaflllpaFSYRSNT-------------ALSFKVYYTLEDFKAK---QKVIFFHPIYLKHLAQFWRSKGV 197

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|..
gi 26351773 202 KNRRqsgsfLSTGWFTMILALELCEEIVVYGMVSDSYCSEKSPRSvpYHYFE 253
Cdd:cd23991 198 QVYR-----LSTGLMITSAALELCEEVKLYGFWPFSKNTEGKPIS--HHYYD 242
GT29_ST8SIA2 cd23987
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase ...
 59-121 1.52e-07

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia2 catalyzes shorter polysialic acid formation of NCAMs than ST8Sia4. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467715  Cd Length: 278  Bit Score: 51.86  E-value: 1.52e-07
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 26351773  59 YSSVPDGKPLIRELCHSCAVVSSSGQMLGSGLGAQIDGAECVLRMNQAPTVGFEEDVGQRSTL 121
Cdd:cd23987  50 YELLPRTSPLKNKHFKTCAIVGNSGILLNSGCGREIDSHDFVIRCNLAPVEEYAKDVGTKTDL 112
GT29_ST6GALNAC2 cd23972
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are ...
 73-120 2.03e-06

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467700  Cd Length: 308  Bit Score: 48.28  E-value: 2.03e-06
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....*...
gi 26351773  73 CHSCAVVSSSGQMLGSGLGAQIDGAECVLRMNQAPTVGFEEDVGQRST 120
Cdd:cd23972  82 CIRCAVVGNGGILNGSRQGRAIDAHDYVFRLNGAVIKGFEEDVGTKTS 129
GT29_ST8SIA5 cd23990
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2, ...
 63-232 4.45e-04

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5 (also known as alpha-2,8-sialyltransferase 8E) is involved in the biosynthesis of gangliosides, such as GD1c, GT1a, GQ1b, and GT3. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467718  Cd Length: 273  Bit Score: 40.98  E-value: 4.45e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26351773  63 PDGKPLIRELCHSCAVVSSSGQMLGSGLGAQIDGAECVLRMNQAP-TVGFEEDVGQRSTLRVIShtsvPLLLRNYSHYFQ 141
Cdd:cd23990  54 PKDMPYSRSQFKKCAVVGNGGILKNSKCGREIDSADFVFRCNLPPiSEKYVRDVGVKTDVVTIN----PSIITERFHKLE 129

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 26351773 142 HARDTLYVVWgQGRHMDRVLGGRTY---------RTLLQLTRMYPGLQVYTFTERMMAYCDQIFQDETGKNRRqsgsfLS 212
Cdd:cd23990 130 KWRRPFYEVL-QVYENASVVLPAFYntrntdvsiRVKYVLDDFESQQAVYYFHPQYLLNVSRFWLRQGVRAKR-----IS 203

                       170       180
                ....*....|....*....|
gi 26351773 213 TGWFTMILALELCEEIVVYG 232
Cdd:cd23990 204 SGLMLVTAALELCEEVHLYG 223
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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